MCID: GRM005
MIFTS: 49

Germ Cell Cancer malady

Rare diseases, Cancer diseases categories

Summaries for Germ Cell Cancer

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Disease Ontology:10 A cell type cancer that has material basis in abnormally proliferating cells derived from germ cells.

MalaCards based summary: Germ Cell Cancer, also known as malignant tumor of the germ cell, is related to testicular cancer and seminoma. An important gene associated with Germ Cell Cancer is AFP (alpha-fetoprotein), and among its related pathways are Glucocorticoid receptor regulatory network and Prolactin signaling pathway. The compounds oestriol and trilostane have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and bone marrow, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Aliases & Classifications for Germ Cell Cancer

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Germ Cell Cancer, Aliases & Descriptions:

Name: Germ Cell Cancer 10 12 45 62
Malignant Tumor of the Germ Cell 10 62
 
Malignant Germ Cell Tumor 43 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology10 DOID:2994
NCIt40 C3708
MeSH35 D009373

Related Diseases for Germ Cell Cancer

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Diseases related to Germ Cell Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1testicular cancer30.9AFP, CGA, SPRY4
2seminoma30.9CGA, ESR2, AFP
3teratoma30.7AFP, CGA
4dysgerminoma30.4CGA, AFP
5choriocarcinoma30.3ESR2, CGA, AFP
6endodermal sinus tumor30.2AFP
7testicular teratoma30.2AFP, CGA
8germinoma30.2AFP, CGA
9embryonal cancer30.2AFP, CGA
10hypospadias30.2CGA, AR
11cryptorchidism30.2CGA, AR
12klinefelter's syndrome30.2AR, CGA
13infertility30.1ESR2, AR, CGA
14breast cancer30.1AR, ESR2
15extragonadal germ cell cancer10.7
16dermatomyositis10.5
17malignant cardiac germ cell tumor10.4
18mixed extragonadal germ cell cancer10.3
19mixed germ cell cancer10.3
20thrombocytopenia10.3
21fallopian tube germ cell cancer10.3
22mature teratoma10.3
23mediastinitis10.3
24pediatric germ cell cancer10.3
25testicular malignant germ cell cancer10.3
26malignant germ cell tumor of the cervix uteri10.3
27mast cell disease10.2
28hepatitis10.2
29langerhans-cell histiocytosis10.2
30neuronitis10.2
31gonadoblastoma10.2
32urticaria pigmentosa10.2
33gestational choriocarcinoma10.2
34histiocytosis10.2
35urticaria10.2
36swyer syndrome10.2
37growing teratoma syndrome10.2
38testicular germ cell tumor10.1
39leukemia10.1
40ulcerative colitis10.1
41intussusception10.1
42cerebritis10.1
43extragonadal nonseminomatous germ cell tumor10.1
44estrogen excess10.1
45autonomic neuropathy10.1
46colitis10.1
47germ cell and embryonal cancer10.1
48hyperthyroidism10.1
49ischemia10.1
50neuropathy10.1

Graphical network of the top 20 diseases related to Germ Cell Cancer:



Diseases related to germ cell cancer

Symptoms for Germ Cell Cancer

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Drugs & Therapeutics for Germ Cell Cancer

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Drug clinical trials:

Search ClinicalTrials for Germ Cell Cancer

Search NIH Clinical Center for Germ Cell Cancer

Genetic Tests for Germ Cell Cancer

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Anatomical Context for Germ Cell Cancer

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MalaCards organs/tissues related to Germ Cell Cancer:

33
Testis, Lymph node, Bone marrow, Bone, Brain, Testes, Liver, Spinal cord, Lung, Breast, Prostate

Animal Models for Germ Cell Cancer or affiliated genes

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MGI Mouse Phenotypes related to Germ Cell Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6AR, ESR2, AFP
2MP:00053798.6AR, CGA, ESR2, AFP
3MP:00053898.5AFP, ESR2, CGA, AR
4MP:00053718.5SPRY4, BLMH, ESR2
5MP:00053868.4AR, ESR2, AFP, BLMH
6MP:00053768.1BLMH, AFP, ESR2, CGA, AR
7MP:00053787.7AR, CGA, ESR2, BLMH, SPRY4
8MP:00107687.6AR, ESR2, AFP, BLMH, SPRY4

Publications for Germ Cell Cancer

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Articles related to Germ Cell Cancer:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
Optimal management of germ cell cancer: more a matter of expertise than of chemotherapy regimen. (25447105)
2015
2
Salvage chemotherapy with gemcitabine plus oxaliplatin for patients with testicular germ cell cancer. (24647526)
2014
3
A practice-changing step forward in germ-cell cancer? (25456352)
2014
4
Identification of known and novel germ cell cancer-specific (embryonic) miRs in serum by high-throughput profiling. (25382245)
2014
5
Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer. (23784843)
2013
6
Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer. (22245602)
2012
7
Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer. (23071246)
2012
8
Germ cell cancer presenting as gastrointestinal bleeding and developing brain metastases: case report and review of the literature. (23148621)
2012
9
Burden or relief: do second-opinion centers influence the quality of care delivered to patients with testicular germ cell cancer? (19931248)
2010
10
Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer. (19010497)
2009
11
High-dose chemotherapy plus stem cell transplantation in advanced germ cell cancer: a review. (19303697)
2009
12
European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. (18191324)
2008
13
Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. (18936476)
2008
14
Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. (18632724)
2008
15
Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A. (18039775)
2008
16
Clinical impact of MDR1-expression in testicular germ cell cancer. (18004247)
2007
17
Bevacizumab plus high-dose ifosfamide, etoposide and carboplatin (HD-ICE) as third-line salvage chemotherapy induced an unexpected dramatic response in highly platinum refractory germ-cell cancer. (16234294)
2006
18
The efficacy of different follow-up strategies in clinical stage I Non-seminomatous Germ Cell Cancer: a Markov simulation study. (15964134)
2005
19
A phase II trial of TIP (paclitaxel, ifosfamide and cisplatin) given as second-line (post-BEP) salvage chemotherapy for patients with metastatic germ cell cancer: a medical research council trial. (15999102)
2005
20
Secondary leukemia after first-line high-dose chemotherapy for patients with advanced germ cell cancer. (15627215)
2005
21
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients. (15900213)
2005
22
Pathologic findings and therapeutic outcome of desperation post-chemotherapy retroperitoneal lymph node dissection in advanced germ cell cancer. (16301122)
2005
23
High-dose etoposide, thiotepa, and dose-adjusted carboplatin (TVCa) with autologous hematopoietic stem cell rescue as treatment of relapsed or refractory germ cell cancer. (15803005)
2005
24
Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer. (15365067)
2004
25
Survival of patients with nonseminomatous germ cell cancer: a review of the IGCC classification by Cox regression and recursive partitioning. (15026798)
2004
26
Combination chemotherapy with gemcitabine plus oxaliplatin in patients with intensively pretreated or refractory germ cell cancer: a study of the German Testicular Cancer Study Group. (14701772)
2004
27
Impact of therapy and androgen receptor polymorphism on sperm concentration in men treated for testicular germ cell cancer: a longitudinal study. (15105386)
2004
28
Testis conserving chemotherapy in germ cell cancer: its potential to increase understanding of the biology and treatment of carcinoma-in-situ. (12752243)
2003
29
Physical activity in long-term survivors of germ-cell cancer. (12763205)
2003
30
Treatment of testicular germ-cell cancer: a cochrane evidence-based systematic review. (12435371)
2002
31
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
32
Paclitaxel, ifosfamide, and cisplatin second-line therapy for patients with relapsed testicular germ cell cancer. (10856101)
2000
33
Future prospects in the chemotherapy of metastatic nonseminomatous testicular germ-cell cancer. (10552153)
1999
34
A molecular model for the development of germ cell cancer. (10597200)
1999
35
BOMP/EPI intensive alternating chemotherapy for IGCCC poor-prognosis germ-cell tumors: the Spanish Germ-Cell Cancer Group experience (GG) (10355572)
1999
36
Germ cell cancer and dermatomyositis. (9543617)
1998
37
Testicular germ-cell cancer. (9227931)
1997
38
Fertility after chemotherapy for testicular germ cell cancer. (9207575)
1997
39
Gonadal function after multimodality treatment in men with testicular germ cell cancer. (8640293)
1996
40
Results of postchemotherapy adjunctive retroperitoneal lymph node dissection in non-seminomatous germ cell cancer patients. (8961487)
1996
41
Pilot study of a high-dose carboplatin-based salvage strategy for relapsing or refractory germ cell cancer. (7627721)
1995
42
High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group. (7911158)
1994
43
Dose-dependent impairment of testicular function in patients treated with cisplatin-based chemotherapy for germ cell cancer. (8075033)
1994
44
High-dose epirubicin in chemotherapy refractory non-seminomatous germ cell cancer: a phase II study. EORTC Genito-Urinary Tract Cancer Co-operative Group. EORTC Early Clinical Trials Group. (1323325)
1992
45
Management of patients with poor-prognosis nonseminomatous germ cell cancer. (1692984)
1990
46
Long-term fertility and Leydig cell function in patients treated for germ cell cancer with cisplatin, vinblastine, and bleomycin versus surveillance. (1698935)
1990
47
Dose-intensive chemotherapy in refractory germ cell cancer--a phase I/II trial of high-dose carboplatin and etoposide with autologous bone marrow transplantation. (2544687)
1989
48
Metastatic germ cell cancer--a curable neoplasm. (2681625)
1989
49
Long-term effects on renal function and blood pressure of treatment with cisplatin, vinblastine, and bleomycin in patients with germ cell cancer. (2460594)
1988
50
Poorly differentiated carcinoma or extragonadal germ cell cancer. (3032035)
1987

Variations for Germ Cell Cancer

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Expression for genes affiliated with Germ Cell Cancer

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Search GEO for disease gene expression data for Germ Cell Cancer.

Pathways for genes affiliated with Germ Cell Cancer

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Pathways related to Germ Cell Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CGA, AFP
2
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.5CGA, ESR2
39.4AR, CGA
49.3AR, ESR2
59.3ESR2, AR
6
Show member pathways
Nuclear Receptors38
9.3AR, ESR2

Compounds for genes affiliated with Germ Cell Cancer

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Compounds related to Germ Cell Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1oestriol4510.0CGA, AFP
2trilostane45 1310.9CGA, ESR2
3estradiol benzoate459.9ESR2, CGA
4leuprolide acetate459.8ESR2, CGA
5hpte45 3010.8AR, ESR2
6anastrozole45 51 1311.8ESR2, CGA
74-tert-octylphenol459.8AR, ESR2
8leuprolide45 61 30 1312.8AR, CGA
9hydroxyflutamide45 3010.7AR, CGA
10nandrolone45 2610.7ESR2, AR
115alpha-androstane-3alpha,17beta-diol459.7ESR2, AR
12estramustine45 1310.6ESR2, AR
13exemestane45 51 61 1312.6ESR2, AR
14clomiphene citrate459.5AFP, ESR2, CGA
15bisphenol a459.5AR, ESR2
16bleomycin45 1310.5CGA, AFP, BLMH
17fulvestrant45 51 30 1312.5AR, ESR2
18flutamide45 61 1311.5AR, CGA
19levonorgestrel45 61 30 1312.4AR, ESR2
20dmso459.4CGA, ESR2, AFP
21steroidal459.3ESR2, AR
22estrone45 30 26 1312.3AR, ESR2, AFP
23letrozole45 51 61 1312.3AR, CGA, ESR2
243beta-hydroxysteroid459.3AR, CGA, ESR2
25ifosfamide45 1310.3CGA, AFP
2617beta-hydroxysteroid459.3ESR2, CGA, AR
27androstenedione45 2610.3AR, CGA, ESR2
28progestin459.3ESR2, CGA, AR
29dihydrotestosterone45 30 26 1312.3AR, CGA, ESR2
30bicalutamide45 61 1311.2ESR2, AR
31epinephrine45 26 1311.2AR, CGA, AFP
32chloramphenicol45 3 51 1312.2AR, ESR2, AFP
33gnrh459.2AR, CGA, ESR2
34lactate459.1CGA, AFP, BLMH
35tamoxifen45 51 30 1312.1ESR2, CGA, AR
36diethylstilbestrol45 30 1310.9AR, CGA, ESR2, AFP
37mifepristone45 30 61 1311.9AR, CGA, ESR2, AFP
38etoposide45 51 61 1311.9AFP, ESR2, CGA, AR
39vitamin d458.9AFP, ESR2, CGA, AR
40doxorubicin45 51 1310.9AR, CGA, ESR2, AFP
41actinomycin d458.9AFP, ESR2, CGA, AR
42estradiol45 26 1310.9AFP, ESR2, CGA, AR
43paraffin458.9AFP, ESR2, CGA, AR
44progesterone45 30 61 26 1312.9AFP, ESR2, CGA, AR
45h2o2458.9AR, CGA, ESR2, AFP
46testosterone45 61 26 1311.9AFP, ESR2, CGA, AR
47steroid458.8AFP, ESR2, CGA, AR
48vegf458.8AFP, ESR2, CGA, AR
49glutamate458.8AFP, ESR2, CGA, AR
50estrogen458.7AFP, ESR2, CGA, AR

GO Terms for genes affiliated with Germ Cell Cancer

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Biological processes related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00071658.9AR, CGA, ESR2
2cell-cell signalingGO:00072678.6AR, CGA, ESR2

Molecular functions related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00048799.3AR, ESR2

Products for genes affiliated with Germ Cell Cancer

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Sources for Germ Cell Cancer

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet