MCID: GRM005
MIFTS: 35

Germ Cell Cancer malady

Cancer diseases category

Summaries for Germ Cell Cancer

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63Wikipedia, 32MalaCards
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Wikipedia:63 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

MalaCards: Germ Cell Cancer is related to testicular cancer and seminoma. An important gene associated with Germ Cell Cancer is SOX17 (SRY (sex determining region Y)-box 17), and among its related pathways are Glycoprotein hormones and Folate biosynthesis. The compounds cycloheximide and luteinizing hormone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and testis germ, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Aliases & Classifications for Germ Cell Cancer

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10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

germ cell cancer 10 44 60


Related Diseases for Germ Cell Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Germ Cell Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1testicular cancer31.6AFP, ALPP
2seminoma30.7SOX17, CGA, AFP, FGF4, KITLG, ESR2
3ovarian cancer30.6LHCGR, XPA, AR, AFP, CYP1B1, ESR2
4embryonal cancer30.4CGA, AFP, FGF4, KITLG, ALPP, ALPPL2
5hypospadias30.1CGA, AR
6hyperthyroidism30.0ALPPL2, ALPP, CGA
7cryptorchidism30.0AR, CGA, ALPP, ALPPL2
8infertility30.0LHCGR, AR, CGA, POLG, ESR2
9prostate cancer30.0AR, CYP3A5, CYP1B1, FGF4, ESR2, ALPP
10breast cancer30.0LHCGR, AR, CYP3A5, CYP1B1, FGF4, ESR2
11leukemia30.0CYP3A5, CYP1B1, FGF4, B3GAT1, KITLG, ESR2
12extragonadal germ cell cancer10.6
13retroperitoneal cancer10.6
14lymph node cancer10.5
15in situ carcinoma10.4
16dermatomyositis10.4
17testicular malignant germ cell cancer10.4
18brain cancer10.4
19mixed germ cell cancer10.3
20cell type cancer10.2
21fallopian tube germ cell cancer10.2
22mature teratoma10.2
23mediastinal cancer10.2
24mediastinitis10.2
25pediatric germ cell cancer10.2
26thrombocytopenia10.2
27malignant germ cell tumor of the cervix uteri10.2
28ovarian germ cell malignant tumor10.2
29estrogen excess10.1
30klinefelter's syndrome10.1
31cerebritis10.1
32intussusception10.1
33ulcerative colitis10.1
34autonomic neuropathy10.1
35germ cell and embryonal cancer10.1
36ischemia10.1
37lung cancer10.1
38malignant teratoma10.1
39neuropathy10.1
40orbital cancer10.1
41prostatitis10.1
42pyloric stenosis10.1
43spinal cancer10.1
44spinal cord ischemia10.1
45testicular disease10.1
46testis seminoma10.1
47vascular cancer10.1
48vaginal germ cell malignant tumor10.1
49malignant germ cell tumor of the corpus uteri10.1
50malignant dysgerminomatous germ cell tumor10.1

Graphical network of the top 20 diseases related to Germ Cell Cancer:



Diseases related to germ cell cancer

Clinical Features for Germ Cell Cancer

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Drugs & Therapeutics for Germ Cell Cancer

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Germ Cell Cancer

Drug clinical trials:

Search ClinicalTrials for Germ Cell Cancer

Search NIH Clinical Center for Germ Cell Cancer

Search CenterWatch for Germ Cell Cancer

Genetic Tests for Germ Cell Cancer

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Anatomical Context for Germ Cell Cancer

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32MalaCards
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MalaCards organs/tissues related to Germ Cell Cancer:

32
Ovary, Testis, Testis germ

Animal Models for Germ Cell Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Germ Cell Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2POLG, LHCGR
2MP:00053719.9XPA, BLMH, FGF4, SPRY4
3MP:00053899.8RLN1, LHCGR, CGA, AFP, POLG, KITLG
4MP:00053799.7ESR2, RLN1, LHCGR, SOX17, AFP, POLG
5MP:00020069.7XPA, AR, AFP, CYP1B1, KITLG, ESR2
6MP:00107719.5RLN1, AR, POLG, KITLG
7MP:00053909.4RLN1, XPA, AR, POLG, FGF4, KITLG
8MP:00053769.0RLN1, LHCGR, XPA, AR, CGA, AFP
9MP:00053788.9RLN1, LHCGR, SOX17, XPA, AR, CGA
10MP:00107688.9AFP, AR, XPA, SOX17, RLN1, POLG

Publications for Germ Cell Cancer

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Genetic Variations for Germ Cell Cancer

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Expression for genes affiliated with Germ Cell Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germ Cell Cancer

Search GEO for disease gene expression data for Germ Cell Cancer.

Pathways for genes affiliated with Germ Cell Cancer

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53Reactome, 29KEGG
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Pathways related to Germ Cell Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CGA, LHCGR
210.1ALPPL2, ALPP
310.1CYP1B1, CGA, LHCGR

Compounds for genes affiliated with Germ Cell Cancer

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Germ Cell Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5ALPP
2luteinizing hormone4410.5LHCGR, CGA
3hpte44 2811.5AR, ESR2
4leuprolide acetate4410.5LHCGR, CGA, ESR2
54-tert-octylphenol4410.5AR, ESR2
6clomiphene citrate4410.5CGA, AFP, ESR2
7diethylstilbestrol44 28 1112.4AR, CGA, AFP, ESR2
8hydroxyflutamide44 2811.4CGA, AR, ALPP
93beta-hydroxysteroid4410.4AR, CGA, LHCGR, ESR2
10exemestane49 44 59 1113.4AR, CYP1B1, ESR2
11letrozole44 49 59 1113.4CYP1B1, AR, CGA, ESR2
1217beta-hydroxysteroid4410.4AR, CGA, CYP1B1, ESR2
13mifepristone44 59 28 1113.3AFP, AR, ESR2, CGA, CYP3A5
14androstenedione44 2411.2CYP3A5, ESR2, CYP1B1, CGA, AR
15flutamide44 59 1112.2CYP1B1, CGA, AR, LHCGR, CYP3A5
16estrone44 28 11 2413.2AR, CYP1B1, CYP3A5, ESR2, AFP
17ifosfamide44 1111.2CYP3A5, AFP, CGA
18h2o24410.2AR, AFP, ESR2, ALPP, CGA
19gnrh4410.2LHCGR, AR, CGA, KITLG, ESR2
20cyclophosphamide44 49 1112.2CYP1B1, KITLG, CYP3A5, AFP, CGA
21chloramphenicol44 2 1112.1AFP, AR, ESR2, CYP3A5, ALPP
22etoposide44 49 59 1113.1CGA, AR, AFP, ESR2, CYP1B1, CYP3A5
23ribonucleic acid4410.1ESR2, CGA, KITLG, LHCGR, CYP3A5
24doxorubicin44 49 1112.1CYP1B1, KITLG, AR, CGA, ESR2, AFP
25vitamin d4410.1ESR2, AFP, ALPP, AR, CGA
26simvastatin44 49 59 28 11 2415.1AFP, KITLG, ALPP, CYP3A5
27progestin4410.1ALPP, LHCGR, CGA, AR, RLN1, ESR2
28dmso4410.0CGA, AFP, KITLG, ESR2, ALPP, CYP1B1
29actinomycin d4410.0CGA, KITLG, AFP, AR, ESR2
30ketoconazole44 28 11 2413.0CYP3A5, CYP1B1, AR
31quercetin44 59 11 2413.0CYP1B1, AR, ESR2, ALPP
32lactate4410.0AFP, BLMH, ALPP, CGA, KITLG, POLG
33dexamethasone44 49 28 1112.9ALPP, KITLG, CYP3A5, AFP, AR, CYP1B1
34steroid449.9AFP, AR, ESR2, KITLG, CYP1B1, CGA
35adenylate449.9ESR2, KITLG, LHCGR, CYP1B1, CGA, POLG
36paraffin449.9KITLG, AFP, ESR2, CGA, ALPPL2, ALPP
375-aza-2deoxycytidine449.9KITLG, ESR2, AR, CYP1B1
38tamoxifen44 49 28 1112.9CYP3A5, CYP1B1, ALPP, AR, CGA, ESR2
39estradiol44 11 2411.8AFP, LHCGR, KITLG, CYP1B1, CYP3A5, ESR2
40heparin44 28 11 2412.8ALPP, B3GAT1, AFP, CGA, FGF4, KITLG
41progesterone44 59 28 11 2413.8CYP1B1, B3GAT1, ESR2, CYP3A5, CGA, AR
42vegf449.8AR, AFP, FGF4, KITLG, ESR2, ALPP
43glutamate449.8LHCGR, XPA, CGA, AFP, CYP1B1, AR
44genistein44 28 59 2 11 2414.8ALPP, AR, ESR2, KITLG, CYP1B1
45arginine449.8ESR2, LHCGR, CGA, RLN1, AR, B3GAT1
46alanine449.7ALPP, AFP, LHCGR, XPA, KITLG, CGA
47parathion44 2410.7CYP1B1, CYP3A5, POLG
48retinoic acid44 2410.6AR, AFP, CYP3A5, CYP1B1, FGF4, ALPP
49testosterone44 59 11 2412.5ALPP, KITLG, B3GAT1, CYP1B1, CYP3A5, LHCGR
50serine449.3CYP1B1, AFP, LHCGR, AR, CGA, ALPP

GO Terms for genes affiliated with Germ Cell Cancer

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16Gene Ontology
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Biological processes related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:06006510.3ESR2, LHCGR
2prostate gland epithelium morphogenesisGO:06074010.2ESR2, AR
3response to toxic substanceGO:00963610.1CYP1B1, BLMH, XPA
4cell-cell signalingGO:0072679.8AR, CGA, FGF4, ESR2
5male gonad developmentGO:0085849.8KITLG, AR, LHCGR
6signal transductionGO:0071659.6AR, CGA, FGF4, KITLG, ESR2, RLN1

Molecular functions related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.1ALPPL2, ALPP

Products for genes affiliated with Germ Cell Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Germ Cell Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet