MCID: GRM005
MIFTS: 52

Germ Cell Cancer malady

Rare diseases, Cancer diseases categories
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Summaries for Germ Cell Cancer

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Wikipedia:65 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

MalaCards based summary: Germ Cell Cancer, also known as malignant tumor of the germ cell, is related to teratoma and seminoma. An important gene associated with Germ Cell Cancer is AFP (alpha-fetoprotein), and among its related pathways are Glucocorticoid receptor regulatory network and Prolactin signaling pathway. The compounds oestriol and trilostane have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testis germ, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from germ cells.

Aliases & Classifications for Germ Cell Cancer

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Germ Cell Cancer, Aliases & Descriptions:

Name: Germ Cell Cancer 8 10 44 62
Malignant Tumor of the Germ Cell 8 62
 
Malignant Germ Cell Tumor 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


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Disease Ontology8 DOID:2994
MeSH34 D009373
NCIt39 C3708

Related Diseases for Germ Cell Cancer

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Diseases related to Germ Cell Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.0AFP, CGA
2seminoma30.9CGA, ESR2, AFP
3endodermal sinus tumor30.8AFP
4testicular cancer30.8AFP, CGA, SPRY4
5dysgerminoma30.7CGA, AFP
6germinoma30.5AFP, CGA
7choriocarcinoma30.4ESR2, CGA, AFP
8embryonal cancer30.4AFP, CGA
9hypospadias30.3CGA, AR
10cryptorchidism30.3CGA, AR
11klinefelter's syndrome30.3AR, CGA
12infertility30.0ESR2, AR, CGA
13breast cancer30.0AR, ESR2
14extragonadal germ cell cancer10.7
15oligohydramnios10.4AFP
16dermatomyositis10.4
17leydig cell tumor10.4CGA
18germ cell tumors10.4
19malignant cardiac germ cell tumor10.4
20sertoli cell tumor10.4AR
21mixed extragonadal germ cell cancer10.3
22mixed germ cell cancer10.3
23male germ cell tumor, somatic10.3AFP, CGA
24edwards syndrome10.3CGA, AFP
25anencephaly10.3AFP, CGA
26thrombocytopenia10.2
27fallopian tube germ cell cancer10.2
28mature teratoma10.2
29mediastinitis10.2
30pediatric germ cell cancer10.2
31testicular malignant germ cell cancer10.2
32thromboembolism10.2
33malignant germ cell tumor of the cervix uteri10.2
34neural tube defects10.2AFP, CGA
35hepatitis10.2
36langerhans-cell histiocytosis10.2
37urticaria pigmentosa10.2
38neuronitis10.2
39gonadoblastoma10.2
40gestational choriocarcinoma10.2
41histiocytosis10.2
42urticaria10.2
43swyer syndrome10.2
44growing teratoma syndrome10.2
45ovarian cyst10.2ESR2, CGA
46penis agenesis10.2AR, CGA
47androgen insensitivity syndrome10.2AR, CGA
48prolactinoma10.2CGA, ESR2
49gynecomastia10.2AR, CGA
50oligospermia10.1AR, CGA

Graphical network of the top 20 diseases related to Germ Cell Cancer:



Diseases related to germ cell cancer

Symptoms for Germ Cell Cancer

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Drugs & Therapeutics for Germ Cell Cancer

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Drug clinical trials:

Search ClinicalTrials for Germ Cell Cancer

Search NIH Clinical Center for Germ Cell Cancer

Genetic Tests for Germ Cell Cancer

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Anatomical Context for Germ Cell Cancer

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MalaCards organs/tissues related to Germ Cell Cancer:

32
Testis, Ovary, Testis germ, Lymph node, Bone marrow, Bone, Brain, Liver, Testes, Spinal cord, Lung, Breast, Prostate

Animal Models for Germ Cell Cancer or affiliated genes

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MGI Mouse Phenotypes related to Germ Cell Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ESR2, AR, AFP
2MP:00053798.6AFP, ESR2, CGA, AR
3MP:00053898.5AR, ESR2, CGA, AFP
4MP:00053718.5SPRY4, BLMH, ESR2
5MP:00053868.4BLMH, AFP, AR, ESR2
6MP:00053768.1AR, CGA, ESR2, AFP, BLMH
7MP:00053787.7BLMH, AR, ESR2, CGA, SPRY4
8MP:00107687.6SPRY4, AR, ESR2, AFP, BLMH

Publications for Germ Cell Cancer

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Articles related to Germ Cell Cancer:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Salvage chemotherapy with gemcitabine plus oxaliplatin for patients with testicular germ cell cancer. (24647526)
2014
2
Identification of known and novel germ cell cancer-specific (embryonic) miRs in serum by high-throughput profiling. (25382245)
2014
3
Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer. (23784843)
2013
4
Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer. (22245602)
2012
5
Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer. (23071246)
2012
6
Germ cell cancer presenting as gastrointestinal bleeding and developing brain metastases: case report and review of the literature. (23148621)
2012
7
Burden or relief: do second-opinion centers influence the quality of care delivered to patients with testicular germ cell cancer? (19931248)
2010
8
Canadian consensus guidelines for the management of testicular germ cell cancer. (20368885)
2010
9
Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer. (19010497)
2009
10
High-dose chemotherapy plus stem cell transplantation in advanced germ cell cancer: a review. (19303697)
2009
11
European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. (18191324)
2008
12
Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. (18936476)
2008
13
Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. (18632724)
2008
14
Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A. (18039775)
2008
15
Survival of metastatic germ cell cancer patients assessed by international germ cell consensus classification in Japan. (18321891)
2008
16
Bevacizumab plus high-dose ifosfamide, etoposide and carboplatin (HD-ICE) as third-line salvage chemotherapy induced an unexpected dramatic response in highly platinum refractory germ-cell cancer. (16234294)
2006
17
The efficacy of different follow-up strategies in clinical stage I Non-seminomatous Germ Cell Cancer: a Markov simulation study. (15964134)
2005
18
A phase II trial of TIP (paclitaxel, ifosfamide and cisplatin) given as second-line (post-BEP) salvage chemotherapy for patients with metastatic germ cell cancer: a medical research council trial. (15999102)
2005
19
Secondary leukemia after first-line high-dose chemotherapy for patients with advanced germ cell cancer. (15627215)
2005
20
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients. (15900213)
2005
21
Pathologic findings and therapeutic outcome of desperation post-chemotherapy retroperitoneal lymph node dissection in advanced germ cell cancer. (16301122)
2005
22
High-dose etoposide, thiotepa, and dose-adjusted carboplatin (TVCa) with autologous hematopoietic stem cell rescue as treatment of relapsed or refractory germ cell cancer. (15803005)
2005
23
Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer. (15365067)
2004
24
Survival of patients with nonseminomatous germ cell cancer: a review of the IGCC classification by Cox regression and recursive partitioning. (15026798)
2004
25
Combination chemotherapy with gemcitabine plus oxaliplatin in patients with intensively pretreated or refractory germ cell cancer: a study of the German Testicular Cancer Study Group. (14701772)
2004
26
Impact of therapy and androgen receptor polymorphism on sperm concentration in men treated for testicular germ cell cancer: a longitudinal study. (15105386)
2004
27
Testis conserving chemotherapy in germ cell cancer: its potential to increase understanding of the biology and treatment of carcinoma-in-situ. (12752243)
2003
28
Physical activity in long-term survivors of germ-cell cancer. (12763205)
2003
29
Treatment of testicular germ-cell cancer: a cochrane evidence-based systematic review. (12435371)
2002
30
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
31
Paclitaxel, ifosfamide, and cisplatin second-line therapy for patients with relapsed testicular germ cell cancer. (10856101)
2000
32
Future prospects in the chemotherapy of metastatic nonseminomatous testicular germ-cell cancer. (10552153)
1999
33
A molecular model for the development of germ cell cancer. (10597200)
1999
34
BOMP/EPI intensive alternating chemotherapy for IGCCC poor-prognosis germ-cell tumors: the Spanish Germ-Cell Cancer Group experience (GG) (10355572)
1999
35
Germ cell cancer and dermatomyositis. (9543617)
1998
36
Testicular germ-cell cancer. (9227931)
1997
37
Fertility after chemotherapy for testicular germ cell cancer. (9207575)
1997
38
Gonadal function after multimodality treatment in men with testicular germ cell cancer. (8640293)
1996
39
Results of postchemotherapy adjunctive retroperitoneal lymph node dissection in non-seminomatous germ cell cancer patients. (8961487)
1996
40
Pilot study of a high-dose carboplatin-based salvage strategy for relapsing or refractory germ cell cancer. (7627721)
1995
41
High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group. (7911158)
1994
42
Dose-dependent impairment of testicular function in patients treated with cisplatin-based chemotherapy for germ cell cancer. (8075033)
1994
43
High-dose epirubicin in chemotherapy refractory non-seminomatous germ cell cancer: a phase II study. EORTC Genito-Urinary Tract Cancer Co-operative Group. EORTC Early Clinical Trials Group. (1323325)
1992
44
Management of patients with poor-prognosis nonseminomatous germ cell cancer. (1692984)
1990
45
Long-term fertility and Leydig cell function in patients treated for germ cell cancer with cisplatin, vinblastine, and bleomycin versus surveillance. (1698935)
1990
46
Dose-intensive chemotherapy in refractory germ cell cancer--a phase I/II trial of high-dose carboplatin and etoposide with autologous bone marrow transplantation. (2544687)
1989
47
Metastatic germ cell cancer--a curable neoplasm. (2681625)
1989
48
Enhanced pulmonary toxicity in smokers with germ-cell cancer treated with cis-platinum, vinblastine and bleomycin: a long-term follow-up. (2469589)
1989
49
Long-term effects on renal function and blood pressure of treatment with cisplatin, vinblastine, and bleomycin in patients with germ cell cancer. (2460594)
1988
50
Poorly differentiated carcinoma or extragonadal germ cell cancer. (3032035)
1987

Variations for Germ Cell Cancer

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Expression for genes affiliated with Germ Cell Cancer

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Expression patterns in normal tissues for genes affiliated with Germ Cell Cancer

Search GEO for disease gene expression data for Germ Cell Cancer.

Pathways for genes affiliated with Germ Cell Cancer

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Pathways related to Germ Cell Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CGA, AFP
2
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.5CGA, ESR2
39.4AR, CGA
49.3AR, ESR2
59.3ESR2, AR
6
Show member pathways
Nuclear Receptors37
9.3AR, ESR2

Compounds for genes affiliated with Germ Cell Cancer

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Compounds related to Germ Cell Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1oestriol4410.0CGA, AFP
2trilostane44 1110.9CGA, ESR2
3estradiol benzoate449.9ESR2, CGA
4leuprolide acetate449.8ESR2, CGA
5hpte44 2810.8AR, ESR2
6anastrozole44 50 1111.8ESR2, CGA
74-tert-octylphenol449.8AR, ESR2
8leuprolide44 61 28 1112.8AR, CGA
9hydroxyflutamide44 2810.7AR, CGA
10nandrolone44 2410.7ESR2, AR
115alpha-androstane-3alpha,17beta-diol449.7ESR2, AR
12estramustine44 1110.6ESR2, AR
13exemestane44 50 61 1112.6ESR2, AR
14clomiphene citrate449.5AFP, ESR2, CGA
15bisphenol a449.5AR, ESR2
16bleomycin44 1110.5CGA, AFP, BLMH
17fulvestrant44 50 28 1112.5AR, ESR2
18flutamide44 61 1111.5AR, CGA
19levonorgestrel44 61 28 1112.4AR, ESR2
20dmso449.4CGA, ESR2, AFP
21steroidal449.3ESR2, AR
22estrone44 28 24 1112.3AR, ESR2, AFP
23letrozole44 50 61 1112.3AR, CGA, ESR2
243beta-hydroxysteroid449.3AR, CGA, ESR2
25ifosfamide44 1110.3CGA, AFP
2617beta-hydroxysteroid449.3ESR2, CGA, AR
27androstenedione44 2410.3AR, CGA, ESR2
28progestin449.3ESR2, CGA, AR
29dihydrotestosterone44 28 24 1112.3AR, CGA, ESR2
30bicalutamide44 61 1111.2ESR2, AR
31epinephrine44 24 1111.2AR, CGA, AFP
32chloramphenicol44 2 50 1112.2AR, ESR2, AFP
33gnrh449.2AR, CGA, ESR2
34lactate449.1CGA, AFP, BLMH
35tamoxifen44 50 28 1112.1ESR2, CGA, AR
36diethylstilbestrol44 28 1110.9AR, CGA, ESR2, AFP
37mifepristone44 28 61 1111.9AR, CGA, ESR2, AFP
38etoposide44 50 61 1111.9AFP, ESR2, CGA, AR
39vitamin d448.9AFP, ESR2, CGA, AR
40doxorubicin44 50 1110.9AR, CGA, ESR2, AFP
41actinomycin d448.9AFP, ESR2, CGA, AR
42estradiol44 24 1110.9AFP, ESR2, CGA, AR
43paraffin448.9AFP, ESR2, CGA, AR
44progesterone44 28 61 24 1112.9AFP, ESR2, CGA, AR
45h2o2448.9AR, CGA, ESR2, AFP
46testosterone44 61 24 1111.9AFP, ESR2, CGA, AR
47steroid448.8AFP, ESR2, CGA, AR
48vegf448.8AFP, ESR2, CGA, AR
49glutamate448.8AFP, ESR2, CGA, AR
50estrogen448.7AFP, ESR2, CGA, AR

GO Terms for genes affiliated with Germ Cell Cancer

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Biological processes related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:0071658.9AR, CGA, ESR2
2cell-cell signalingGO:0072678.6AR, CGA, ESR2

Molecular functions related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.3AR, ESR2

Products for genes affiliated with Germ Cell Cancer

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Sources for Germ Cell Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet