MCID: GRM005
MIFTS: 45

Germ Cell Cancer malady

Cancer category

Summaries for Germ Cell Cancer

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

MalaCards: Germ Cell Cancer is related to testicular cancer and teratoma. An important gene associated with Germ Cell Cancer is SOX17 (SRY (sex determining region Y)-box 17), and among its related pathways are Glycoprotein hormones and Folate biosynthesis. The compounds cycloheximide and luteinizing hormone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Aliases & Classifications for Germ Cell Cancer

Sources:
10DISEASES, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

germ cell cancer 10 45 61


Related Diseases for Germ Cell Cancer

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Germ Cell Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1testicular cancer31.7AFP, ALPP
2teratoma30.6CGA, AFP, ALPP, ALPPL2
3hypospadias30.1CGA, AR
4cryptorchidism30.1AR, CGA, ALPP, ALPPL2
5bone marrow cancer10.5
6testicular malignant germ cell cancer10.4
7brain cancer10.4
8testis seminoma10.4
9nonseminomatous germ cell tumor10.3
10thrombocytopenia10.2
11germ cell tumors10.2
12testicular germ cell tumor10.2
13malignant germ cell tumor of the cervix uteri10.2
14ovarian germ cell malignant tumor10.2
15estrogen excess10.1
16klinefelter's syndrome10.1
17intussusception10.1
18ulcerative colitis10.1
19autonomic neuropathy10.1
20spinal cancer10.1
21spinal cord ischemia10.1
22t cell deficiency10.1
23testicular disease10.1
24vascular cancer10.1
25clostridium difficile10.1
26mass syndrome10.1
27oral cancer10.1
28testicular cancer, childhood10.1
29testicular microlithiasis10.1
30vaginal germ cell malignant tumor10.1
31malignant germ cell tumor of the corpus uteri10.1
32malignant dysgerminomatous germ cell tumor10.1
33hemangioma10.0FGF4
34esophageal cancer10.0FGF4
35fascioliasis10.0ALPP
36leiomyoma10.0ESR2
37cholestasis10.0ALPPL2, ALPP
38hepatitis10.0ALPP, AFP
39thyroiditis10.0CGA
40cholelithiasis10.0ALPPL2, ALPP
41teratocarcinoma10.0FGF4
42stomach cancer10.0FGF4, AFP
43diarrhea10.0ALPPL2, ALPP
44male germ cell tumor, somatic10.0CGA, AFP
45leydig cell tumor10.0CGA, LHCGR
46sertoli cell tumor10.0ALPP, AR
47fibrous dysplasia10.0ALPP, ALPPL2
48androgen insensitivity syndrome10.0CGA, AR
49hepatitis b10.0AFP, ALPP, ALPPL2
50germinoma10.0CGA, AFP, ALPP

Graphical network of the top 20 diseases related to Germ Cell Cancer:



Diseases related to germ cell cancer

Clinical Features for Germ Cell Cancer

Drugs & Therapeutics for Germ Cell Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Germ Cell Cancer

Drug clinical trials:

Search ClinicalTrials for Germ Cell Cancer

Search NIH Clinical Center for Germ Cell Cancer

Search CenterWatch for Germ Cell Cancer

Genetic Tests for Germ Cell Cancer

Anatomical Context for Germ Cell Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Germ Cell Cancer:

33
Bone marrow, Whole blood, Lymph node, Brain, Spinal cord, Liver, Lung, Breast, Skin, Ovary, Prostate, Testis, T cells, B cells, Testis germ, Testis leydig

Animal Models for Germ Cell Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Germ Cell Cancer

Sources:
51PubMed
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Articles related to Germ Cell Cancer:

(show top 50)    (show all 416)
idTitleAuthorsYear
1
Just another brick in the wall: unravelling the epigenetic mechanism underlying tumour initiation of testicular germ cell cancer. (24292446)
2013
2
High dose chemotherapy with autologous stem cell transplantation for patients with germ-cell cancer. (23613419)
2013
3
Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas. (23885216)
2013
4
Re: Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer. (24120784)
2013
5
Undescended testis: the underlying mechanisms and the effects on germ cells that cause infertility and cancer. (23701757)
2013
6
Randomized phase III study comparing paclitaxel-bleomycin, etoposide, and cisplatin (BEP) to standard BEP in intermediate-prognosis germ-cell cancer: intergroup study EORTC 30983. (22271474)
2012
7
GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). (23029259)
2012
8
Testicular cancer: a new generation of biomarkers for malignant germ cell tumours. (22549310)
2012
9
Is testicular germ cell cancer associated with increased muscle mass or adiposity? (21253772)
2011
10
Development of testicular germ cell cancer following successful infliximab induction therapy for ulcerative colitis. (21453887)
2011
11
Proceedings of the 7th Copenhagen Workshop on Testicular Carcinoma in situ and Germ Cell Cancer, 13-15 October 2010. (21790649)
2011
12
Epigenetic modulation of cancer-germline antigen gene expression in tumorigenic human mesenchymal stem cells: implications for cancer therapy. (19498007)
2009
13
Incidental CNS involvement of testicular germ cell cancer: a growing trend? (19464744)
2009
14
Physical activity in adolescence and testicular germ cell cancer risk. (19399630)
2009
15
Management of poor-prognosis or relapsed germ-cell cancer. (19840019)
2009
16
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. (19483682)
2009
17
Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (18507837)
2008
18
Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. (18398146)
2008
19
Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer. (19075141)
2008
20
Contralateral intratubular germ cell neoplasia in a patient with testicular cancer. (18398407)
2008
21
Clinical impact of MDR1-expression in testicular germ cell cancer. (18004247)
2007
22
Bevacizumab plus high-dose ifosfamide, etoposide and carboplatin (HD-ICE) as third-line salvage chemotherapy induced an unexpected dramatic response in highly platinum refractory germ-cell cancer. (16234294)
2006
23
Retroperitoneal lymph-node dissection after chemotherapy for germ cell cancer in patients with elevated tumor markers. (16691234)
2006
24
Testicular germ-cell cancer. (16517276)
2006
25
Secondary leukemia after first-line high-dose chemotherapy for patients with advanced germ cell cancer. (15627215)
2005
26
Survival of patients with nonseminomatous germ cell cancer: a review of the IGCC classification by Cox regression and recursive partitioning. (15026798)
2004
27
Relapse-free and overall survival in patients with pathologic stage II nonseminomatous germ cell cancer treated with etoposide and cisplatin adjuvant chemotherapy. (14752068)
2004
28
Quality of life of survivors of testicular germ cell cancer: a review of the literature. (15179563)
2004
29
Quality of life in good prognosis patients with metastatic germ cell cancer: a prospective study of the European Organization for Research and Treatment of Cancer Genitourinary Group/Medical Research Council Testicular Cancer Study Group (30941/TE20). (12637478)
2003
30
E400P in advanced seminoma of good prognosis according to the international germ cell cancer collaborative group (IGCCCG) classification: the Spanish Germ Cell Cancer Group experience. (11398880)
2001
31
Dermatomyositis and retroperitoneal germ cell cancer. (11150842)
2001
32
Ovarian germ cell cancer: clinicopathologic analysis and outcome of 31 cases. (11218184)
2000
33
Thromboembolic events during chemotherapy for germ cell cancer: a cohort study and review of the literature. (10811682)
2000
34
Comparative tolerability of chemotherapy regimens for germ cell cancer. (10830254)
2000
35
Cisplatin-refractory, HER2/neu-expressing germ-cell cancer: induction of remission by the monoclonal antibody Trastuzumab. (10631474)
1999
36
Antitumoral activity of oxaliplatin/cisplatin-based combination therapy in cisplatin-refractory germ cell cancer patients. (10592105)
1999
37
Treatment of patients with cisplatin-refractory testicular germ-cell cancer. German Testicular Cancer Study Group (GTCSG). (10597209)
1999
38
A rational approach to managing stage I nonseminomatous germ cell cancer. (9728211)
1998
39
Salvage treatment for germ cell cancer after failed high-dose therapy. (9739448)
1998
40
Testicular germ-cell cancer. (9227931)
1997
41
Fertility after chemotherapy for testicular germ cell cancer. (9207575)
1997
42
Impact of preleukapheresis cell counts on collection results and correlation of progenitor-cell dose with engraftment after high-dose chemotherapy in patients with germ cell cancer. (8648365)
1996
43
Effect of irradiation treatment on gonadal function in men treated for germ cell cancer. (8386642)
1993
44
Late-effects after treatment for germ-cell cancer with cisplatin, vinblastine, and bleomycin. (1385050)
1992
45
High prevalence of Clostridium difficile diarrhoea during intensive chemotherapy for disseminated germ cell cancer. (1384640)
1992
46
Metastatic germ cell cancer--a curable neoplasm. (2681625)
1989
47
Raynaud's phenomenon in patients treated with cisplatin, vinblastine, and bleomycin for germ cell cancer: measurement of vasoconstrictor response to cold. (2472472)
1989
48
Experience with PVB in non seminomatous germ-cell cancer of the testis. (2421336)
1985
49
Nonseminomatous germ cell cancer of the testis. Reducing treatment-related morbidity in patients with disseminated disease. (6288223)
1982
50
The unrecognized extragonadal germ cell cancer syndrome. (6162409)
1981

Genetic Variations for Germ Cell Cancer

Expression for genes affiliated with Germ Cell Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germ Cell Cancer

Search GEO for disease gene expression data for Germ Cell Cancer.

Pathways for genes affiliated with Germ Cell Cancer

Sources:
54Reactome, 30KEGG
See all sources

Pathways related to Germ Cell Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CGA, LHCGR
210.1ALPPL2, ALPP
310.1CYP1B1, CGA, LHCGR

Compounds for genes affiliated with Germ Cell Cancer

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Germ Cell Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5ALPP
2luteinizing hormone4510.5LHCGR, CGA
3hpte45 2911.5AR, ESR2
4leuprolide acetate4510.5LHCGR, CGA, ESR2
54-tert-octylphenol4510.5AR, ESR2
6clomiphene citrate4510.5CGA, AFP, ESR2
7diethylstilbestrol45 29 1112.4AR, CGA, AFP, ESR2
8hydroxyflutamide45 2911.4CGA, AR, ALPP
93beta-hydroxysteroid4510.4AR, CGA, LHCGR, ESR2
10exemestane50 45 60 1113.4AR, CYP1B1, ESR2
11letrozole45 50 60 1113.4CYP1B1, AR, CGA, ESR2
1217beta-hydroxysteroid4510.4AR, CGA, CYP1B1, ESR2
13mifepristone45 60 29 1113.3AFP, AR, ESR2, CGA, CYP3A5
14androstenedione45 2411.2CYP3A5, ESR2, CYP1B1, CGA, AR
15flutamide45 60 1112.2CYP1B1, CGA, AR, LHCGR, CYP3A5
16estrone45 29 11 2413.2AR, CYP1B1, CYP3A5, ESR2, AFP
17ifosfamide45 1111.2CYP3A5, AFP, CGA
18h2o24510.2AR, AFP, ESR2, ALPP, CGA
19gnrh4510.2LHCGR, AR, CGA, KITLG, ESR2
20cyclophosphamide45 50 1112.2CYP1B1, KITLG, CYP3A5, AFP, CGA
21chloramphenicol45 2 1112.1AFP, AR, ESR2, CYP3A5, ALPP
22etoposide45 50 60 1113.1CGA, AR, AFP, ESR2, CYP1B1, CYP3A5
23ribonucleic acid4510.1ESR2, CGA, KITLG, LHCGR, CYP3A5
24doxorubicin45 50 1112.1CYP1B1, KITLG, AR, CGA, ESR2, AFP
25vitamin d4510.1ESR2, AFP, ALPP, AR, CGA
26simvastatin45 50 60 29 11 2415.1AFP, KITLG, ALPP, CYP3A5
27progestin4510.1ALPP, LHCGR, CGA, AR, RLN1, ESR2
28dmso4510.0CGA, AFP, KITLG, ESR2, ALPP, CYP1B1
29actinomycin d4510.0CGA, KITLG, AFP, AR, ESR2
30ketoconazole45 29 11 2413.0CYP3A5, CYP1B1, AR
31quercetin45 60 11 2413.0CYP1B1, AR, ESR2, ALPP
32lactate4510.0AFP, BLMH, ALPP, CGA, KITLG, POLG
33dexamethasone45 50 29 1112.9ALPP, KITLG, CYP3A5, AFP, AR, CYP1B1
34steroid459.9AFP, AR, ESR2, KITLG, CYP1B1, CGA
35adenylate459.9ESR2, KITLG, LHCGR, CYP1B1, CGA, POLG
36paraffin459.9KITLG, AFP, ESR2, CGA, ALPPL2, ALPP
375-aza-2deoxycytidine459.9KITLG, ESR2, AR, CYP1B1
38tamoxifen45 50 29 1112.9CYP3A5, CYP1B1, ALPP, AR, CGA, ESR2
39estradiol45 11 2411.8AFP, LHCGR, KITLG, CYP1B1, CYP3A5, ESR2
40heparin45 29 11 2412.8ALPP, B3GAT1, AFP, CGA, FGF4, KITLG
41progesterone45 60 29 11 2413.8CYP1B1, B3GAT1, ESR2, CYP3A5, CGA, AR
42vegf459.8AR, AFP, FGF4, KITLG, ESR2, ALPP
43glutamate459.8LHCGR, XPA, CGA, AFP, CYP1B1, AR
44genistein45 29 60 2 11 2414.8ALPP, AR, ESR2, KITLG, CYP1B1
45arginine459.8ESR2, LHCGR, CGA, RLN1, AR, B3GAT1
46alanine459.7ALPP, AFP, LHCGR, XPA, KITLG, CGA
47parathion45 2410.7CYP1B1, CYP3A5, POLG
48retinoic acid45 2410.6AR, AFP, CYP3A5, CYP1B1, FGF4, ALPP
49testosterone45 60 11 2412.5ALPP, KITLG, B3GAT1, CYP1B1, CYP3A5, LHCGR
50serine459.3CYP1B1, AFP, LHCGR, AR, CGA, ALPP

GO Terms for genes affiliated with Germ Cell Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:06006510.3ESR2, LHCGR
2prostate gland epithelium morphogenesisGO:06074010.2ESR2, AR
3response to toxic substanceGO:00963610.1CYP1B1, BLMH, XPA
4cell-cell signalingGO:0072679.8AR, CGA, FGF4, ESR2
5male gonad developmentGO:0085849.8KITLG, AR, LHCGR
6signal transductionGO:0071659.6AR, CGA, FGF4, KITLG, ESR2, RLN1

Molecular functions related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00403510.1ALPPL2, ALPP

Products for genes affiliated with Germ Cell Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Germ Cell Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet