MCID: GRM005
MIFTS: 42

Germ Cell Cancer malady

Cancer diseases category
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Summaries for Germ Cell Cancer

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65Wikipedia, 33MalaCards
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Wikipedia:65 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

MalaCards: Germ Cell Cancer is related to seminoma and testicular cancer. An important gene associated with Germ Cell Cancer is AFP (alpha-fetoprotein), and among its related pathways are Glucocorticoid receptor regulatory network and Prolactin signaling pathway. The compounds oestriol and trilostane have been mentioned in the context of this disorder. Affiliated tissues include testis, testis germ and ovary, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Aliases & Classifications for Germ Cell Cancer

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10DISEASES, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

germ cell cancer 10 45 62


Related Diseases for Germ Cell Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Germ Cell Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.8CGA, ESR2, AFP
2testicular cancer30.8SPRY4, AFP, CGA
3teratoma30.7CGA, AFP
4embryonal cancer30.2CGA, AFP
5hypospadias30.2AR, CGA
6cryptorchidism30.2CGA, AR
7klinefelter's syndrome30.2AR, CGA
8infertility30.1ESR2, CGA, AR
9breast cancer30.1AR, ESR2
10extragonadal germ cell cancer10.6
11dermatomyositis10.4
12mixed germ cell cancer10.3
13germ cell tumors10.3
14fallopian tube germ cell cancer10.2
15mature teratoma10.2
16mediastinitis10.2
17pediatric germ cell cancer10.2
18testicular malignant germ cell cancer10.2
19thrombocytopenia10.2
20thromboembolism10.2
21malignant germ cell tumor of the cervix uteri10.2
22malignant germ cell tumor of ovary10.2
23endodermal sinus tumor10.1AFP
24oligohydramnios10.1AFP
25leydig cell tumor10.1CGA
26sertoli cell tumor10.1AR
27intussusception10.1
28ulcerative colitis10.1
29cerebritis10.1
30estrogen excess10.1
31autonomic neuropathy10.1
32germ cell and embryonal cancer10.1
33hyperthyroidism10.1
34ischemia10.1
35leukemia10.1
36neuropathy10.1
37prostatitis10.1
38pyloric stenosis10.1
39nonseminomatous germ cell tumor10.1
40venous thromboembolism10.1
41vaginal germ cell malignant tumor10.1
42malignant germ cell tumor of the corpus uteri10.1
43malignant dysgerminomatous germ cell tumor10.1
44male germ cell tumor, somatic10.1CGA, AFP
45edwards syndrome10.1CGA, AFP
46germinoma10.1CGA, AFP
47anencephaly10.1CGA, AFP
48dysgerminoma10.1AFP, CGA
49neural tube defects10.0CGA, AFP
50ovarian cyst10.0ESR2, CGA

Graphical network of the top 20 diseases related to Germ Cell Cancer:



Diseases related to germ cell cancer

Symptoms for Germ Cell Cancer

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Drugs & Therapeutics for Germ Cell Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Germ Cell Cancer

Search NIH Clinical Center for Germ Cell Cancer

Genetic Tests for Germ Cell Cancer

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Anatomical Context for Germ Cell Cancer

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33MalaCards
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MalaCards organs/tissues related to Germ Cell Cancer:

33
Testis, Testis germ, Ovary, Lymph node, Bone, Bone marrow, Brain, Testes, Liver, Lung, Spinal cord, Breast, Prostate

Animal Models for Germ Cell Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Germ Cell Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6AR, ESR2, AFP
2MP:00053798.6AR, CGA, ESR2, AFP
3MP:00053898.5AFP, ESR2, CGA, AR
4MP:00053718.5SPRY4, BLMH, ESR2
5MP:00053868.4AR, ESR2, AFP, BLMH
6MP:00053768.1BLMH, AFP, ESR2, CGA, AR
7MP:00053787.7AR, CGA, ESR2, BLMH, SPRY4
8MP:00107687.6AR, ESR2, AFP, BLMH, SPRY4

Publications for Germ Cell Cancer

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52PubMed
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Articles related to Germ Cell Cancer:

(show top 50)    (show all 313)
idTitleAuthorsYear
1
Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer. (23784843)
2013
2
Sperm concentration, testicular volume and age predict risk of carcinoma in situ in contralateral testis of men with testicular germ cell cancer. (23770148)
2013
3
Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer. (22245602)
2012
4
Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer. (23071246)
2012
5
Germ cell cancer presenting as gastrointestinal bleeding and developing brain metastases: case report and review of the literature. (23148621)
2012
6
Burden or relief: do second-opinion centers influence the quality of care delivered to patients with testicular germ cell cancer? (19931248)
2010
7
Canadian consensus guidelines for the management of testicular germ cell cancer. (20368885)
2010
8
Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer. (19010497)
2009
9
High-dose chemotherapy plus stem cell transplantation in advanced germ cell cancer: a review. (19303697)
2009
10
European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. (18191324)
2008
11
Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. (18936476)
2008
12
Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. (18632724)
2008
13
Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A. (18039775)
2008
14
Survival of metastatic germ cell cancer patients assessed by international germ cell consensus classification in Japan. (18321891)
2008
15
Clinical impact of MDR1-expression in testicular germ cell cancer. (18004247)
2007
16
Bevacizumab plus high-dose ifosfamide, etoposide and carboplatin (HD-ICE) as third-line salvage chemotherapy induced an unexpected dramatic response in highly platinum refractory germ-cell cancer. (16234294)
2006
17
The efficacy of different follow-up strategies in clinical stage I Non-seminomatous Germ Cell Cancer: a Markov simulation study. (15964134)
2005
18
A phase II trial of TIP (paclitaxel, ifosfamide and cisplatin) given as second-line (post-BEP) salvage chemotherapy for patients with metastatic germ cell cancer: a medical research council trial. (15999102)
2005
19
Secondary leukemia after first-line high-dose chemotherapy for patients with advanced germ cell cancer. (15627215)
2005
20
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients. (15900213)
2005
21
Pathologic findings and therapeutic outcome of desperation post-chemotherapy retroperitoneal lymph node dissection in advanced germ cell cancer. (16301122)
2005
22
High-dose etoposide, thiotepa, and dose-adjusted carboplatin (TVCa) with autologous hematopoietic stem cell rescue as treatment of relapsed or refractory germ cell cancer. (15803005)
2005
23
Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer. (15365067)
2004
24
Survival of patients with nonseminomatous germ cell cancer: a review of the IGCC classification by Cox regression and recursive partitioning. (15026798)
2004
25
Combination chemotherapy with gemcitabine plus oxaliplatin in patients with intensively pretreated or refractory germ cell cancer: a study of the German Testicular Cancer Study Group. (14701772)
2004
26
Impact of therapy and androgen receptor polymorphism on sperm concentration in men treated for testicular germ cell cancer: a longitudinal study. (15105386)
2004
27
Testis conserving chemotherapy in germ cell cancer: its potential to increase understanding of the biology and treatment of carcinoma-in-situ. (12752243)
2003
28
Physical activity in long-term survivors of germ-cell cancer. (12763205)
2003
29
Treatment of testicular germ-cell cancer: a cochrane evidence-based systematic review. (12435371)
2002
30
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
31
Paclitaxel, ifosfamide, and cisplatin second-line therapy for patients with relapsed testicular germ cell cancer. (10856101)
2000
32
Future prospects in the chemotherapy of metastatic nonseminomatous testicular germ-cell cancer. (10552153)
1999
33
A molecular model for the development of germ cell cancer. (10597200)
1999
34
BOMP/EPI intensive alternating chemotherapy for IGCCC poor-prognosis germ-cell tumors: the Spanish Germ-Cell Cancer Group experience (GG) (10355572)
1999
35
Germ cell cancer and dermatomyositis. (9543617)
1998
36
Testicular germ-cell cancer. (9227931)
1997
37
Fertility after chemotherapy for testicular germ cell cancer. (9207575)
1997
38
Gonadal function after multimodality treatment in men with testicular germ cell cancer. (8640293)
1996
39
Results of postchemotherapy adjunctive retroperitoneal lymph node dissection in non-seminomatous germ cell cancer patients. (8961487)
1996
40
Pilot study of a high-dose carboplatin-based salvage strategy for relapsing or refractory germ cell cancer. (7627721)
1995
41
High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group. (7911158)
1994
42
Dose-dependent impairment of testicular function in patients treated with cisplatin-based chemotherapy for germ cell cancer. (8075033)
1994
43
High-dose epirubicin in chemotherapy refractory non-seminomatous germ cell cancer: a phase II study. EORTC Genito-Urinary Tract Cancer Co-operative Group. EORTC Early Clinical Trials Group. (1323325)
1992
44
Management of patients with poor-prognosis nonseminomatous germ cell cancer. (1692984)
1990
45
Long-term fertility and Leydig cell function in patients treated for germ cell cancer with cisplatin, vinblastine, and bleomycin versus surveillance. (1698935)
1990
46
Dose-intensive chemotherapy in refractory germ cell cancer--a phase I/II trial of high-dose carboplatin and etoposide with autologous bone marrow transplantation. (2544687)
1989
47
Metastatic germ cell cancer--a curable neoplasm. (2681625)
1989
48
Enhanced pulmonary toxicity in smokers with germ-cell cancer treated with cis-platinum, vinblastine and bleomycin: a long-term follow-up. (2469589)
1989
49
Long-term effects on renal function and blood pressure of treatment with cisplatin, vinblastine, and bleomycin in patients with germ cell cancer. (2460594)
1988
50
Poorly differentiated carcinoma or extragonadal germ cell cancer. (3032035)
1987

Variations for Germ Cell Cancer

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Expression for genes affiliated with Germ Cell Cancer

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germ Cell Cancer

Search GEO for disease gene expression data for Germ Cell Cancer.

Pathways for genes affiliated with Germ Cell Cancer

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 54R&D Systems, 55Reactome
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Pathways related to Germ Cell Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CGA, AFP
2
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.5CGA, ESR2
39.4AR, CGA
49.3AR, ESR2
59.3ESR2, AR
6
Show member pathways
Nuclear Receptors38
9.3AR, ESR2

Compounds for genes affiliated with Germ Cell Cancer

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Germ Cell Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1oestriol4510.0CGA, AFP
2trilostane45 1110.9CGA, ESR2
3estradiol benzoate459.9ESR2, CGA
4leuprolide acetate459.8ESR2, CGA
5hpte45 2910.8AR, ESR2
6anastrozole45 51 1111.8ESR2, CGA
74-tert-octylphenol459.8AR, ESR2
8leuprolide45 61 29 1112.8AR, CGA
9hydroxyflutamide45 2910.7AR, CGA
10nandrolone45 2410.7ESR2, AR
115alpha-androstane-3alpha,17beta-diol459.7ESR2, AR
12estramustine45 1110.6ESR2, AR
13exemestane45 51 61 1112.6ESR2, AR
14clomiphene citrate459.5AFP, ESR2, CGA
15bisphenol a459.5AR, ESR2
16bleomycin45 1110.5CGA, AFP, BLMH
17fulvestrant45 51 29 1112.5AR, ESR2
18flutamide45 61 1111.5AR, CGA
19levonorgestrel45 61 29 1112.4AR, ESR2
20dmso459.4CGA, ESR2, AFP
21steroidal459.3ESR2, AR
22estrone45 29 24 1112.3AR, ESR2, AFP
23letrozole45 51 61 1112.3AR, CGA, ESR2
243beta-hydroxysteroid459.3AR, CGA, ESR2
25ifosfamide45 1110.3CGA, AFP
2617beta-hydroxysteroid459.3ESR2, CGA, AR
27androstenedione45 2410.3AR, CGA, ESR2
28progestin459.3ESR2, CGA, AR
29dihydrotestosterone45 29 24 1112.3AR, CGA, ESR2
30bicalutamide45 61 1111.2ESR2, AR
31epinephrine45 24 1111.2AR, CGA, AFP
32chloramphenicol45 3 51 1112.2AR, ESR2, AFP
33gnrh459.2AR, CGA, ESR2
34lactate459.1CGA, AFP, BLMH
35tamoxifen45 51 29 1112.1ESR2, CGA, AR
36diethylstilbestrol45 29 1110.9AR, CGA, ESR2, AFP
37mifepristone45 29 61 1111.9AR, CGA, ESR2, AFP
38etoposide45 51 61 1111.9AFP, ESR2, CGA, AR
39vitamin d458.9AFP, ESR2, CGA, AR
40doxorubicin45 51 1110.9AR, CGA, ESR2, AFP
41actinomycin d458.9AFP, ESR2, CGA, AR
42estradiol45 24 1110.9AFP, ESR2, CGA, AR
43paraffin458.9AFP, ESR2, CGA, AR
44progesterone45 29 61 24 1112.9AFP, ESR2, CGA, AR
45h2o2458.9AR, CGA, ESR2, AFP
46testosterone45 61 24 1111.9AFP, ESR2, CGA, AR
47steroid458.8AFP, ESR2, CGA, AR
48vegf458.8AFP, ESR2, CGA, AR
49glutamate458.8AFP, ESR2, CGA, AR
50estrogen458.7AFP, ESR2, CGA, AR

GO Terms for genes affiliated with Germ Cell Cancer

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16Gene Ontology
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Biological processes related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:0071658.9AR, CGA, ESR2
2cell-cell signalingGO:0072678.6AR, CGA, ESR2

Molecular functions related to Germ Cell Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.3AR, ESR2

Products for genes affiliated with Germ Cell Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Germ Cell Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet