Germ Cell Tumor malady

Wikipedia: A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or...⁴⁴ more...

MalaCards: Germ Cell Tumor, also known as germ cell tumors, is related to testicular germ cell tumor and male germ cell tumor. An important gene associated with Germ Cell Tumor is MGCT (male germ cell tumor), and among its related pathways are Cell cycle and Cyclins and Cell Cycle Regulation. The compounds vitamin a and dmso have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related mouse phenotypes are reproductive system and respiratory system.

OMIM: 273300

germ cell tumor 7 33 43 germ cell tumors 7 33

Diseases related to germ cell tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 954)

id	Related Disease	Score	Top Affiliating Genes
1	testicular germ cell tumor	46.1	LRP6, PDE11A, KIT, PCNA, BUB1B, GCNT1
2	male germ cell tumor	38.9	KIT, BMP2, RASSF1, ZFP42, CGB5, CDKN1A
3	nonseminomatous germ cell tumor	36.7	CGA, CGB, CGB5, CGB7, APAF1, ERBB2
4	extragonadal germ cell tumor	35.8	CGB, CGB5, CEACAM5, GPC3, SLPI, AFP
5	ovarian germ cell tumor	35.4	PCNA, BRCA2, BIRC5, ERVK-6, TP53, GATA6
6	central nervous system germ cell tumor	35.4	CGB, PDPN, NES, AFP
7	mediastinitis	35.1	KIT, PCNA, CGA, CGB, MLH1, MLL
8	seminoma	34.4	KIT, KITLG, RB1, NANOG, BRAF, RARB
9	teratocarcinoma	33.9	NANOG, BMP2, RARG, RARB, UTF1, ZFP42
10	endodermal sinus tumor	33.5	CGB, CGB5, CEACAM5, INHA, ALPP, ALPPL2
11	germinoma	32.6	KIT, KITLG, BCL2, BAX, CGA, CGB
12	choriocarcinoma	32.1	PIGF, PCNA, LIF, LGALS1, CGA, CGB
13	dysgerminoma	31.7	KIT, KITLG, BRCA2, CGA, CGB, CGB5
14	teratoma	31.2	KIT, PCNA, NANOG, UTF1, LIF, BCL2
15	down syndrome	30.9	RB1, BCL10, CGA, CGB, CGB5, CGB7
16	mature teratoma	30.8	CGA, CGB, ALPP, AFP
17	clear cell renal cell carcinoma	30.3	KIT, VHL, VEGFA, RASSF1, BIRC5, CGB
18	testicular cancer	30.3	PAGE4, LGALS1, XIST, CGA, CGB, CGB5
19	klinefelter's syndrome	30.2	XIST, CGA, CGB, AZF1, AR, INHA
20	testicular germ cell cancer	30.2	KITLG, AR, ALPP, ESR2, DMRT1, CYP1A2
21	dna topoisomerase ii	30.1	PCNA, CDKN1A, CDK2, MLL, MKI67, GSTP1
22	sinusitis	30.0	PCNA, VEGFA, BIRC5, BAX, CGA, CGB7
23	hyperthyroidism	30.0	KITLG, CGA, CGB, CGB5, CGB7, GSR
24	squamous cell carcinoma	29.9	LGALS1, LGALS3, CDH1, MKI67, GSTP1, CCNA2
25	hepatitis	29.8	GSR, FAS, GPC3, HLA-DRB1, TXN, CYP1A2
26	ganglioneuroma	29.6	VHL, RASSF1, CGB, ENO2, PTEN, THBS1
27	renal cell carcinoma	29.4	KIT, PCNA, BRAF, VHL, VEGFA, RARB
28	glioblastoma	29.1	RB1, VHL, VEGFA, BIRC5, PARP1, LGALS1
29	adenomatous polyposis coli	28.9	BUB1B, BIRC5, BCL2, MSH2, CDKN1A, CDK2
30	b-cell lymphomas	28.6	RB1, BIRC3, BIRC5, PARP1, BCL10, BCL2
31	fibrous histiocytoma	28.4	KITLG, PCNA, RB1, VEGFA, BMP2, BCL2
32	histiocytoma	28.4	KITLG, PCNA, RB1, VEGFA, BMP2, BCL2
33	malignant fibrous histiocytoma	28.2	KITLG, PCNA, RB1, VEGFA, BMP2, BCL2
34	cowden disease	28.1	BRCA2, CDKN3, PTEN, SMAD4, STK11
35	hodgkin's lymphoma	28.0	BRCA2, BIRC3, BCL2, LGALS1, XIAP, CDKN2C
36	b-cell non-hodgkin lymphoma	27.9	RB1, VEGFA, BIRC5, BCL10, BCL2, BAX
37	xeroderma pigmentosum	27.9	PCNA, RARG, PARP1, BCL2, BAX, XRCC1
38	carcinoma	26.9	PIGF, LRP6, PDE11A, KIT, KITLG, PCNA
39	non-hodgkin lymphoma	26.7	KITLG, BIRC3, BIRC5, BCL10, BCL2, ZBTB16
40	neuronitis	26.3	LRP6, PDE11A, KIT, KITLG, PCNA, GCNT1
41	ovarian carcinoma	25.1	PIGF, KIT, PCNA, BUB1B, RB1, BRAF
42	polyposis	24.1	KITLG, PCNA, BUB1B, RB1, BRAF, BRCA2
43	neuroblastoma	22.6	KIT, KITLG, PCNA, RB1, NANOG, VHL
44	leukemia	21.7	LRP6, KIT, KITLG, PCNA, BUB1B, GCNT1
45	gestational trophoblastic neoplasm	14.7	PCNA, CGA, CGB, CGB5, CGB7, INHA
46	testicular neoplasm	14.6	KIT, INHA, FGFR3, ALPP, ALPPL2, STK10
47	rectal cloacogenic carcinoma	14.5	PCNA, RB1, BIRC5, CGB, CGB5, CGB7
48	germ cell cancer	14.5	PCNA, CGA, CDKN2A, AR, FGF4, ENO2
49	urinary bladder cancer	14.4	RB1, RASSF1, BIRC5, CGB, AURKA, CDKN1A
50	benign meningioma	14.4	PCNA, BIRC5, MKI67, MDM2, CCNA2, ETS1

Clinical features from OMIM: 273300

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to germ cell tumor:

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MGI Mouse Phenotypes related to germ cell tumor:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	10.5	LRP6, BUB1B, BRCA2, VHL, VEGFA, BMP2
2	respiratory system phenotype	MP:0005388	10.2	LRP6, KIF27, LIF, ZFPM2, LDHA, CDKN2D
3	normal phenotype	MP:0002873	10.2	LRP6, GCNT1, BRAF, BRCA2, VHL, VEGFA
4	endocrine/exocrine gland phenotype	MP:0005379	10.2	BRCA2, RARG, ZFP42, ZFPM2, ZBTB16, YBX2
5	liver/biliary system phenotype	MP:0005370	10.2	LRP6, KIT, VHL, VEGFA, LIF, ZFPM2
6	embryogenesis phenotype	MP:0005380	10.1	LRP6, KIT, BUB1B, NANOG, BRAF, BRCA2
7	renal/urinary system phenotype	MP:0005367	9.9	LRP6, KIT, GCNT1, BRAF, VHL, RARB
8	behavior/neurological phenotype	MP:0005386	9.7	LRP6, PDE11A, KIT, GCNT1, RB1, BRAF
9	limbs/digits/tail phenotype	MP:0005371	9.7	LRP6, KIT, KITLG, RB1, BRCA2, VHL
10	no phenotypic analysis	MP:0003012	9.7	LRP6, PCNA, RB1, NANOG, VEGFA, ZFPM2
11	immune system phenotype	MP:0005387	9.5	KIT, KIF27, BUB1B, GCNT1, BRAF, BRCA2
12	hematopoietic system phenotype	MP:0005397	9.5	KIT, PCNA, BUB1B, GCNT1, BRAF, BRCA2
13	craniofacial phenotype	MP:0005382	9.5	LRP6, KIT, KITLG, KIF27, RARG, LATS2
14	skeleton phenotype	MP:0005390	9.5	LRP6, KIT, KITLG, BUB1B, RB1, BRAF
15	digestive/alimentary phenotype	MP:0005381	9.3	LRP6, KIT, KITLG, GCNT1, RB1, BRAF
16	vision/eye phenotype	MP:0005391	9.2	LRP6, KIT, KITLG, BUB1B, RB1, BRAF
17	adipose tissue phenotype	MP:0005375	9.1	LRP6, BUB1B, RB1, BRAF, LIF, BCL2
18	tumorigenesis	MP:0002006	8.9	KIT, KITLG, BUB1B, RB1, BRAF, BRCA2
19	muscle phenotype	MP:0005369	8.7	KIT, BUB1B, RB1, BRAF, VHL, VEGFA
20	pigmentation phenotype	MP:0001186	8.7	KIT, KITLG, RB1, BRAF, BCL2, XPA
21	integument phenotype	MP:0010771	8.5	LRP6, KIT, KITLG, BUB1B, RB1, BRAF
22	growth/size phenotype	MP:0005378	8.4	LRP6, KIT, KITLG, KIF27, BUB1B, RB1
23	hearing/vestibular/ear phenotype	MP:0005377	8.3	LRP6, KIT, KITLG, KIF27, RB1, BMP2
24	nervous system phenotype	MP:0003631	8.3	LRP6, PDE11A, KIT, KITLG, KIF27, RB1
25	mortality/aging	MP:0010768	8.1	LRP6, KITLG, KIF27, RB1, NANOG, BRAF
26	cardiovascular system phenotype	MP:0005385	7.4	KIT, KITLG, KIF27, RB1, BRAF, VHL
27	cellular phenotype	MP:0005384	6.5	LRP6, KIT, KITLG, KIF27, PCNA, BUB1B
28	homeostasis/metabolism phenotype	MP:0005376	6.5	LRP6, KIT, KITLG, BUB1B, RB1, BRAF

Articles related to germ cell tumor:

(show top 50)    (show all 300)

id	Title	Authors	Year	Affiliating Genes
1	Differential Akt signalling in non-seminomatous testi cular germ cell tumors. (22110200)	Hennenlotter J.... Bedke J.	2011	PTEN, CDKN1B
2	RNA-binding protein LIN28 is a marker for primary ext ragonadal germ cell tumors: an immunohistochemical study of 131 cases. (21057460)	Cao D.... Li J.	2011	SALL4, LIN28A
3	Brain metastases in children and adolescents with ext racranial germ cell tumor - data of the MAHO/MAKEI-registry. (20514616)	GAPbel U.... Calaminus G.	2010	CGB5
4	Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gen e alteration in human germ cell tumor cell lines. (20113831)	Ogino H.... Masutani M.	2010	PARP1
5	Core 2 N-acetylglucosaminyltransferase-1 expression i nduces aggressive potential of testicular germ cell tumor. (20017138)	Hatakeyama S.... Ohyama C.	2010	GCNT1
6	Prevalence of paraneoplastic hyperthyroidism in patie nts with metastatic non-seminomatous germ-cell tumors. (19605510)	Oosting S.F.... Gietema J.A.	2010	CGA
7	Differential expression of SOX2 and SOX17 in testicular germ cell tumors. (19369635)	Nonaka D.	2009	SOX17, SOX8
8	BCL10 single nucleotide polymorphism and its associat ion with CSF dissemination of primary intracranial germ cell tumors. (19690445)	Hayashi Y.... Hamada J.	2009	CASP9, BCL10
9	Insulin-like growth factor 1, insulin-like growth factor-binding protein 3, and testicular germ-cell tumor risk. (18408226)	Chia V.M.... McGlynn K.A.	2008	IGFBP3
10	False-positive serum human chorionic gonadotropin (HCG) in a male patient with a malignant germ cell tumor of the testis: a case report and review of the literature. (18984875)	Ballieux B.E.... Osanto S.	2008	CGB5
11	Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. (18069663)	Linger R.... Rapley E.A.	2008	DND1
12	Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. (17413983)	Hamel N.... Foulkes W.D.	2007	BRCA2
13	Repression of cyclin D1 as a target for germ cell tumors. (17203214)	Freemantle S.J.... Dmitrovsky E.	2007	CCND1
14	Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms. (17951198)	Yu H.... Hornick J.L.	2007	PDPN
15	Survivin expression in ovarian germ cell tumors (17441339)	Yin R.T.... Kang D.Y.	2007	BIRC5
16	Significance of primary tumor size and preorchiectomy serum tumor marker level in predicting pathologic stage at retroperitoneal lymph node dissection in clinical Stage A nonseminomatous germ cell tumors. (17382165)	Beck S.D.... Donohue J.P.	2007	AFP, CGB
17	Mixed nonseminomatous germ cell tumor presenting as a subcutaneous tissue mass. (17122498)	Maubec E.... Theodore C.	2006	CGB7
18	Oncofetal protein glypican-3 in testicular germ-cell tumor. (16896894)	Ota S.... Fukayama M.	2006	GPC3, AFP
19	Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. (16424014)	Korkola J.E.... Chaganti R.S.	2006	FGF4, ZFP42
20	Erasure of methylation imprint at the promoter and CTCF-binding site upstream of H19 in human testicular germ cell tumors of adolescents indicate their fetal germ cell origin. (16434968)	Kawakami T.... Okamoto K.	2006	H19
21	Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors. (16810501)	Kempkensteffen C.... Schrader M.	2006	PRSS21
22	The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes. (15896468)	Weikert S.... Miller K.	2005	BIRC5
23	Expression and distribution of c-kit receptor and its ligand in human CNS germ cell tumors: a useful histological marker for the diagnosis of germinoma. (15696963)	Takeshima H.... Kuratsu J.	2004	KITLG
24	High lactate dehydrogenase isoenzyme 1 in a patient with malignant germ cell tumor is attributable to aberrant methylation of the LDHA gene. (15297388)	Ishikawa J.... Maekawa M.	2004	LDHA
25	Molecular determinants of treatment response in human germ cell tumors. (12576448)	Mayer F.... Bokemeyer C.	2003	GSTP1, RB1, BCL2
26	Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum. (12777991)	Saad R.S.... Silverman J.F.	2003	ALPPL2, KRT7, NKX2-1
27	Prognostic value of tumor size, metastases, extension into bone, and increased tumor marker in children with malignant sacrococcygeal germ cell tumors: a prospective evaluation of 71 patients treated in the German cooperative protocols Maligne Keimzelltumoren (MAKEI) 83/86 and MAKEI 89. (12610174)	Calaminus G.... GAPbel U.	2003	AFP
28	hH-Rev107, a class II tumor suppressor gene, is expressed by post-meiotic testicular germ cells and CIS cells but not by human testicular germ cell tumors. (11526504)	Siegrist S.... Bulle F.	2001	PLA2G16
29	Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. (11358847)	Schmidt B.A.... Ackermann R.	2001	CDK4, CDK2, CDK6
30	A novel SMAD4 gene mutation in seminoma germ cell tumors. (10706106)	Bouras M.... Benahmed M.	2000	SMAD4
31	Intracranial germ cell tumors in children with and wi thout Down syndrome. (10206462)	Chik K.... Yuen P.M.	1999	CGB7
32	Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumors. (10189147)	Ross J.A.... Davies S.M.	1999	IGF2, H19
33	mdm-2 expression in human testicular germ-cell tumors and its clinical value. (10629640)	Eid H.... Bak M.	1999	MDM2
34	Lack of BCL10 mutations in germ cell tumors and B cell lymphomas. (10380920)	Fakruddin J.M.... Murty V.V.	1999	BCL10
35	Mixed tumors of the pineal area. Diagnosis and therapy consisting of secreting germ cell tumor (9673977)	Hilker R.... Heiss W.D.	1998	AFP
36	Chemotherapy of metastatic testicular germ cell tumors: relationship of histologic response to size reduction and changes in tumor markers. (9535605)	Koshida K.... Namiki M.	1998	ALPP, CGB
37	Mediastinal germ-cell tumor associated with AML (M7)--the syndrome of mediastinal germ-cell tumors associated with hematologic neoplasia? (9796404)	Kitazume K.... Urabe A.	1998	MLL
38	Frequent p16INK4 (MTS1) gene inactivation in testicular germ cell tumors. (9284835)	Chaubert P.... Shaw P.	1997	CDK4
39	Detection of vital germ cell tumor cells in short-term cell cultures of primary tumors and of retroperitoneal metastasis--clinical implications. (9144879)	Otto T.... RA1bben H.	1997	AFP
40	A case of extragonadal germ cell tumor with elevated postchemotherapy HCG successfully treated by resection of a solitary metastasis and chronic oral etoposide. (8609693)	Ohtsu T.... Sasaki Y.	1996	CGB5
41	Effective administration of recombinant granulocyte colony-stimulating factor to prevent granulocytopenia due to combination chemotherapy for testicular germ cell tumors (8918674)	Nonomura K.... Adachi Y.	1996	CSF3
42	Fine needle aspiration cytology of primary mediastinal germ cell tumors. (7543237)	Motoyama T.... Watanabe H.	1995	ALPPL2
43	Successful treatment with combined chemotherapy (carboplatin, etoposide, adriamycin, bleomycin) and radiotherapy for recurrent intracranial malignant germ cell tumor: case report (7541899)	Yoshizawa H.... Nagashima C.	1995	AFP
44	Overexpression or mutation of the p53 tumor suppressor gene does not occur in malignant ovarian germ cell tumors. (8625105)	Liu F.S.... Shih A.	1995	TP53
45	Hematopoietic precursor cells within the yolk sac tumor component are the source of secondary hematopoietic malignancies in patients with mediastinal germ cell tumors. (8389653)	Orazi A.... Nichols C.R.	1993	TP53
46	Serum AFP, hCG and CEA in the management of patients with testicular, ovarian and extragonadal germ cell tumors. (1378875)	Motawy M.S.... Ali M.A.	1992	CEACAM5, AFP, CGB5
47	Monitoring of patients with non-seminomatous germ cell tumors of the testis by determination of alpha-fetoprotein and beta-human chorionic gonadotropin levels and by computed tomography. (1283444)	Kausitz J.... Matoska J.	1992	CGB
48	Intracranial germ cell tumors (1320996)	Shen W.C.... Lee K.R.	1992	CGB5
49	Multiple biological markers in germ cell tumor patients treated with platinum-based chemotherapy. (1319825)	Perera F.P.... Jensen R.H.	1992	GYPA
50	Hyperthyroidism in men with germ cell tumors and high levels of beta-human chorionic gonadotropin. (1371235)	Giralt S.A.... Logothetis C.	1992	CGB

Genes related to germ cell tumor according to GeneCards:

(show top 50)    (show all 242)

id	Symbol	Description	Score	GeneCards Section Context
1	MGCT	male germ cell tumor	11.1	Publications, Aliases & Descriptions
2	TGCT1	testicular germ cell tumor susceptibility 1	11.1	Aliases & Descriptions
3	ALPPL2	alkaline phosphatase, placental-like 2	11.1	Expressions, Summaries, Publications
4	GGTA1P	glycoprotein, alpha-galactosyltransferase 1 pseudogene	11.1	Summaries
5	AFP	alpha-fetoprotein	11.0	Publications
6	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
7	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
8	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
9	APAF1	apoptotic peptidase activating factor 1	11.0	Publications
10	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
11	TP53	tumor protein p53	11.0	Publications
12	HIC1	hypermethylated in cancer 1	11.0	Publications
13	FGF4	fibroblast growth factor 4	11.0	Publications
14	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0	Publications
15	CCND2	cyclin D2	11.0	Publications
16	PDPN	podoplanin	11.0	Publications
17	ERVK-6	endogenous retrovirus group K, member 6	11.0	Publications
18	STK11	serine/threonine kinase 11	11.0
19	GPC3	glypican 3	11.0	Publications
20	STK10	serine/threonine kinase 10	11.0	Publications
21	CCNA2	cyclin A2	11.0	Publications
22	FGFR3	fibroblast growth factor receptor 3	11.0
23	CDK2	cyclin-dependent kinase 2	11.0	Publications
24	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
25	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
26	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
27	PCNA	proliferating cell nuclear antigen	11.0	Publications
28	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
29	MIR372	microRNA 372	11.0	Publications
30	MIR371A	microRNA 371a	11.0	Publications
31	MIR373	microRNA 373	11.0	Publications
32	SPANXF1	SPANX family, member F1	11.0	Publications
33	SPANXE	SPANX family, member E	11.0	Publications
34	SPANXB2	SPANX family, member B2	11.0	Publications
35	DPPA3	developmental pluripotency associated 3	11.0	Expressions
36	DND1	dead end homolog 1 (zebrafish)	11.0	Publications
37	SPANXD	SPANX family, member D	11.0	Publications
38	PAGE4	P antigen family, member 4 (prostate associated)	11.0	Publications
39	SPANXA2	SPANX family, member A2	11.0	Publications
40	SPANXB1	SPANX family, member B1	11.0	Publications
41	SPANXA1	sperm protein associated with the nucleus, X-linked, family member A1	11.0	Publications
42	INHBE	inhibin, beta E	11.0	Publications
43	PHLDA3	pleckstrin homology-like domain, family A, member 3	11.0	Publications
44	TSPY1	testis specific protein, Y-linked 1	11.0	Publications
45	SOX17	SRY (sex determining region Y)-box 17	11.0	Publications
46	MAGEC2	melanoma antigen family C, 2	11.0	Publications
47	PRSS21	protease, serine, 21 (testisin)	11.0	Publications
48	SPANXC	SPANX family, member C	11.0	Publications
49	INHBC	inhibin, beta C	11.0	Publications
50	SOX8	SRY (sex determining region Y)-box 8	11.0	Publications

Pathways related to germ cell tumor according to GeneDecks:

(show top 50)    (show all 206)

id	Pathway	Score	Top Affiliating Genes
1	Cell cycle20	11.5	CCND2, CCND1, CCNA1, TP53, SMAD4, TGFB1
2	Cyclins and Cell Cycle Regulation36	11.4	RB1, CDK6, CDKN1A, CDKN2C, CDKN2B, CDKN2D
3	G1-S Phase Transition36	11.3	CCND2, TGFB1, TP53, CCNA1, CCND1, CCNA2
4	Cell Cycle / Checkpoint Control3	11.2	MGMT, MLH1, CDK1, CDK4, CDKN2A, CDKN1B
5	GADD45 Pathway36	11.2	CCNA2, CCNB1, CCNA1, CCNE1, CDK4, CDK2
6	Breast Cancer Regulation by Stathmin136	11.0	BMP2, ERBB2, IGF1R, CCNB1, CCNE1, GRB7
7	Cell cycle Regulation of G1/S transition (part 1)10	11.0	CDK6, TGFB1, SMAD4, CCNA1, CCND1, CCND2
8	Bladder cancer20	11.0	FGFR3, CDH1, CDK4, CDKN2A, CDKN1A, RASSF1
9	Cell cycle_Regulation of G1/S transition (part 1)41	11.0	CCNA1, CCND1, CCND2, CCNA2, CCNE1, CDK4
10	Cell cycle Cell cycle (generic schema)10	10.9	CDK6, CDK2, CDK4, CDK1, CCNB1, CCNA2
11	Cell cycle_Cell cycle (generic schema)41	10.9	CDK6, RB1, CDK2, CCND1, CCND2, CCNA2
12	Glioblastoma Multiforme36	10.7	IGF2, RB1, BRAF, CDK6, CDKN1A, IGF1R
13	Pancreatic cancer20	10.7	CDK6, BRCA2
14	Chronic myeloid leukemia20	10.7	TP53, HRAS, TGFB1, CDK4, KRAS, SMAD4
15	Melanoma20	10.6	CDH1, CDK4, CDKN2A, CDKN1A, CDK6, BRAF
16	Cell cycle ESR1 regulation of G1/S transition10	10.6	ESR1, CCNA1, CDKN1B, CDK4, CDK2, CDKN1A
17	Glioma20	10.5	EGFR, KRAS, PDGFRA, PTEN, TP53, HRAS
18	Cell cycle_ESR1 regulation of G1/S transition41	10.5	ESR1, CCNE1, CCNA1, RB1, CCND1, CDK6
19	p53 signaling pathway20	10.4	TP53, CASP9, CASP8, CASP3, IGF1, IGFBP3
20	Selected targets of Oct-3/410	10.3	PDGFRA, SMAD4, FGF4, INHBB, CDH1, T
21	Non-small cell lung cancer20	10.3	RB1, BRAF, RASSF1, CDK6, CDKN2A, CDK4
22	Small cell lung cancer20	10.2	BIRC3, BCL2, XIAP, CDK6, CDK2, CDKN2B
23	Endothelin-1 Signaling Pathway36	10.2	KIT, PDGFRA, EGFR, CSF3, ERBB2, HRAS
24	Colorectal Cancer Metastasis36	10.1	WNT8A, CDKN1A, MSH6, MSH2, BAX, BIRC5
25	Akt Signaling36	10.1	BMP2, CCND2, CCND1, IGF1R, CASP9, TNF
26	Colorectal cancer20	10.1	MSH2, MSH6, CASP9, TGFB1, BRAF
27	Apoptosis Signaling Pathways37	10.1	BIRC3, BIRC5, BCL2, BAX, TP53, CASP9
28	Pancreatic Adenocarcinoma36	9.9	FGF4, CCND1, CDK4, CDKN2A, CDKN1B, CDKN2D
29	Apoptotic Pathways in Synovial Fibroblasts36	9.9	IL3, FGFR3, FGFR1, FGF8, FGF4, FGF2
30	eNOS Signaling36	9.8	CCNA2, FGFR1, FGF8, CASP8, KIT, FGF4
31	Apoptosis and survival_Caspase cascade41	9.7	DFFA, FAS, IGF1R, IGF1, CASP3, CASP8
32	Telomerase Components in Cell Signaling36	9.6	KIT, KITLG, RB1, BMP2, FGF2, FLT1
33	Apoptosis and survival Caspase cascade10	9.6	TNF, CASP9, CASP8, CASP3, IGF1, IGF1R
34	Prostate cancer20	9.6	NKX3-1, EGFR, KRAS, PDGFRA, PTEN, TP53
35	Nanog in Mammalian ESC Pluripotency36	9.5	WNT8A, POU5F1, SOX2, TGFB1, EGFR, PDGFRA
36	ERK Signaling36	9.5	CSF3, IL10, FGF4, FGF8, FLT1, BMP2
37	Cytokine-cytokine receptor interaction20	9.3	INHBC, INHBB, TNF, IL3, FAS, INHBA
38	Pathways in cancer20	9.2	FADD, MDM2, FGFR3, FGFR1, FGF8, FGF4
39	Mitochondrial Apoptosis36	9.1	EGFR, PDGFRA, TP53, CASP9, CASP8, CASP3
40	Molecular Mechanisms of Cancer36	9.1	TNFRSF8, TNFSF8, PTEN, PDGFRA, LTA, EGFR
41	Apoptosis20	9.1	APAF1, IL3, XIAP, BAX, BCL2, FADD
42	Apoptosis and Autophagy3	9.1	APAF1, DFFA, TFAP2C, TYMP, PHLDA3, TNF
43	p53 Signaling36	9.0	CDK4, CDKN1A, BAX, BCL2, TP53, MDM2
44	Cellular Apoptosis Pathway36	9.0	CASP3, IGF1, IGF2, IGF1R, FADD, APAF1
45	DHA Signaling36	8.9	IGF1R, APAF1, IL3, FGFR3, FGFR1, FGF8
46	Estrogen Pathway36	8.9	FGF8, IGF2, IGF1, HRAS, ESR1, ESR2
47	p53 Mediated Apoptosis36	8.8	FGFR3, KIT, KITLG, FGFR1, FGF8, FGF4
48	p38 Signaling36	8.6	BCL2, IGF1, CASP3, IGF2, IGF1R, FGFR3
49	Antioxidant Action of Vitamin-C36	8.5	LIF, BMP2, KITLG, KIT, EGFR, TGFB1
50	PAK Pathway36	8.4	CASP3, IGF1, IGF2, IGF1R, IL3, IL10

Compounds related to germ cell tumor according to GeneDecks:

(show top 50)    (show all 434)

id	Compound	Score	Top Affiliating Genes
1	vitamin a32 9 18 9	13.7	RB1, RARG, RARB, BIRC5, CHKA, CGA
2	dmso32	10.6	KITLG, CGA, CGB5, ALPP, TERC, CYP1B1
3	egcg32	10.6	XIAP, CDK6, CDK2, IGFBP3, CASP9, ERVK-6
4	p00232	10.5	KIT, RB1, BRAF, BRCA2, BIRC5, XRCC1
5	crcs32	10.5	RB1, BRAF, RASSF1, BIRC5, CEACAM5, MSH2
6	azathioprine32 34 9 9	13.5	PCNA, BMP2, RARB, RASSF1, LIF, CDKN2B
7	melphalan32 9 9	12.4	BIRC5, MGMT, GSTP1, FGFR3, CCNB1, IGF1R
8	bromodeoxyuridine32	10.3	KITLG, PCNA, RB1, CDKN1A, CDK2, CDKN1B
9	irinotecan32 34 9 9	13.3	KIT, BRAF, VEGFA, PARP1, BAX, XRCC1
10	thymidylate32	10.2	PCNA, RB1, VEGFA, BIRC5, BCL2, BAX
11	12-o-tetradecanoylphorbol 13-acetate32	10.1	RB1, BRAF, RARB, LIF, CDKN1A, CDKN1B
12	gefitinib32 34 9 9	13.1	KIT, VEGFA, BIRC5, CEACAM5, CDK6, CDKN1A
13	cyclic amp32 18	11.1	PDE11A, RB1, BRAF, RARB, LIF, CHKA
14	5-aza-2deoxycytidine32	10.1	KITLG, PCNA, VHL, RARB, RASSF1, CDKN1A
15	progestin32	10.0	VEGFA, LIF, CGA, CGB5, CDK6, CDK4
16	erlotinib32 34 9 9	13.0	KIT, VEGFA, BIRC5, CDKN1B, CDKN3, CDH1
17	aspartate32	10.0	PCNA, BRAF, CGA, AURKA, CDKN2A, CDH1
18	3,3-diindolylmethane32	9.9	VEGFA, BIRC5, PARP1, BAX, CDK6, CDKN1A
19	formaldehyde32 18	10.9	KIT, PCNA, RB1, LGALS3, CDKN1B, CDKN3
20	2-methoxyestradiol32 18	10.8	PCNA, BCL2, BAX, CDKN1A, CDK2, ANXA5
21	gnrh32	9.7	KITLG, CGB, CGB5, CGB7, MKI67, AR
22	methylcellulose32	9.7	KIT, KITLG, BMP2, LIF, CDH1, FGF2
23	valine32	9.6	KIT, BRAF, CDK6, CDK2, CDKN2A, CDK4
24	progesterone32 42 9 18 9	13.6	KIT, PCNA, RB1, BRAF, BRCA2, BMP2
25	rapamycin32 42	10.6	KIT, KITLG, RB1, BRAF, VHL, VEGFA
26	2-chlorodeoxyadenosine32	9.5	KIT, BIRC5, PARP1, BCL2, BAX, XIAP
27	noxa32	9.5	BIRC5, BCL2, BAX, XIAP, CDKN1A, MDM2
28	methotrexate32 34 42 9 9	13.4	KIT, KITLG, PCNA, RB1, BRCA2, BIRC5
29	resveratrol32 9 18 9	12.4	PCNA, RB1, BRCA2, VEGFA, BMP2, BIRC5
30	glutamate32	9.3	PCNA, BRAF, LGALS3, CHKA, XIAP, MSH2
31	heparin32 9 18 9	12.3	KITLG, LIF, LGALS1, LGALS3, CGA, CDK2
32	taxane32	9.2	VEGFA, BIRC5, BCL2, AURKA, CDKN1A, ESR1
33	curcumin32	9.2	VEGFA, BIRC3, BIRC5, PARP1, BCL2, BAX
34	cysteine32	9.2	LRP6, PCNA, RARB, LIF, PARP1, LGALS1
35	topotecan32 9 9	11.1	BIRC5, PARP1, BCL2, MGMT, GSTP1, CCNA2
36	gemcitabine32 34 9 9	11.9	PCNA, VEGFA, BIRC3, BIRC5, PARP1, BCL2
37	hoechst 3334232	8.8	KITLG, PCNA, BIRC5, PARP1, BCL2, BAX
38	bortezomib32 9 9	10.7	VEGFA, BIRC5, PARP1, BCL2, BAX, XIAP
39	testosterone32 9 18 9	11.7	KIT, KITLG, PCNA, RB1, BRCA2, BMP2
40	h2o232	8.7	KITLG, BRCA2, LIF, LGALS3, CGA, CGB5
41	agarose32	8.5	KIT, KITLG, LIF, PARP1, BCL2, LGALS1
42	cyclosporin a32 42	9.5	KITLG, BMP2, LIF, CGA, CGB5, CDK2
43	carboplatin32 34 9 9	11.4	KITLG, RB1, VEGFA, LIF, PARP1, BCL2
44	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	8.3	PCNA, PARP1, BCL2, BAX, FAS, ANXA5
45	alanine32	8.2	KITLG, PCNA, BRAF, BMP2, RASSF1, BIRC3
46	arginine32	8.2	BRAF, BMP2, RARB, LIF, LGALS1, XRCC1
47	doxorubicin32 34 9 9	11.2	KIT, KITLG, BUB1B, BIRC3, PARP1, CHKA
48	etoposide32 42 9 9	11.1	PCNA, RB1, BIRC3, BIRC5, PARP1, BCL2
49	paclitaxel32 34 9 9	10.8	KIT, KITLG, PCNA, BUB1B, RB1, BRAF
50	dexamethasone32 42 34 9 9	11.2	KITLG, PCNA, RB1, VEGFA, BMP2, RARB

Cellular components related to germ cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.5	CDK6, CCND1, CCND2, CCNE1, CDKN1A, CDK2
2	cytoplasm	GO:005737	9.8	DND1, TP53, TRO, TRIM27, ERVK-6, ESX1
3	transcription factor complex	GO:005667	9.8	PARP1, ETS1, CDK4, CDK2, SMAD4, SOX17
4	nucleoplasm	GO:005654	9.2	AR, MGMT, MDM2, CCNE1, CCNB1, CCNA2
5	cytosol	GO:005829	9.2	NME1, CASP8, CASP3, HSD17B1, CCNA1, CCND1
6	extracellular space	GO:005615	8.5	GPC3, IL3, IGF2, IGFALS, IL10, FGF8
7	nucleus	GO:005634	8.5	FLT1, MAGEA1, MAGEC2, CCNE1, CCNB1, CCNA2

Biological processes related to germ cell tumor according to GeneDecks:

(show top 50)    (show all 92)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of phosphorylation	GO:042326	11.2	INHBA, INHA, CDKN2A, CDKN1B, CDKN2D, CDKN2B
2	mitotic cell cycle	GO:000278	11.2	CCNA2, BIRC5, TOP2A, PCNA, BUB1B, RB1
3	Ras protein signal transduction	GO:007265	11.1	CCNA2, RB1, RASSF1, CDKN1A, IGF1, HRAS
4	G1 phase of mitotic cell cycle	GO:000080	11.0	CDKN2C, CCND1, CDK4, CDKN1B, CDKN2D, CDKN2B
5	estrogen metabolic process	GO:008210	10.9	HSD17B1, HSD17B4, SULT1A1, SULT1E1, CYP1B1, COMT
6	positive regulation of cell division	GO:051781	10.8	FGF8, NKX3-1, TGFB1, IGF2, APC, FGF4
7	negative regulation of cell growth	GO:030308	10.8	SOX17, STK11, TGFB1, CDKN2A, INHBA, SMAD4
8	positive regulation of cell migration	GO:030335	10.8	VEGFA, CGA, FLT1, GRB7, APC, TGFB1
9	cell division	GO:051301	10.8	CDK4, CDK1, CCNA2, MAD2L1, CCNE1, CCNB1
10	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.8	FAS, BAX, FADD, APAF1, NKX3-1, CDKN1B
11	cell cycle arrest	GO:007050	10.8	RB1, CDKN2A, CDKN3, INHA, INHBA, APC
12	insulin receptor signaling pathway	GO:008286	10.8	STK11, FGF3, FGF2, CDK1, FGF8, FGFR1
13	positive regulation of phospholipase C activity	GO:010863	10.7	PDGFRA, FGF2, FLT1, KIT, FGFR1
14	response to estradiol stimulus	GO:032355	10.7	ESR1, AURKA, BRCA2, ENO2, TGFB1, CYP19A1
15	induction of apoptosis	GO:006917	10.6	TGFB1, PHLDA3, TNF, ETS1, CASP3, FAS
16	negative regulation of cyclin-dependent protein kinase activity	GO:045736	10.6	LATS2, CDKN1A, CDKN1B, CDKN2A, APC, CASP3
17	negative regulation of transcription, DNA-dependent	GO:045892	10.6	MDM2, GATA6, NKX3-1, SOX8, SOX5, PRAME
18	positive regulation of protein phosphorylation	GO:001934	10.6	BMP2, VEGFA, CCND1, ERBB2, CCND2, IGF2
19	positive regulation of MAPK cascade	GO:043410	10.5	KIT, IGF1, SOX2, HRAS, IGFBP3, IGF2
20	regulation of cyclin-dependent protein kinase activity	GO:000079	10.5	PTEN, CCNA1, CCNA2, CCNB1, CCNE1, CDKN3
21	positive regulation of gene expression	GO:010628	10.5	DNMT3B, FGF8, KRAS, TGFB1, CDK1, PRDM1
22	MAPK cascade	GO:000165	10.5	CDK1, FGF8, FGFR1, TGFB1, EGFR, HRAS
23	negative regulation of epithelial cell proliferation	GO:050680	10.4	PTEN, ESR2, AR, CDKN2B, RB1, CDK6
24	positive regulation of transcription, DNA-dependent	GO:045893	10.4	IGF1, CCNA2, CCNE1, IL10, FGF2, INHBA
25	canonical Wnt receptor signaling pathway	GO:060070	10.4	LRP6, RARG, T, FGF8, APC, CCND1
26	G1/S transition of mitotic cell cycle	GO:000082	10.4	INHBA, CDK4, CDK1, LATS2, CCNE1, CCNB1
27	positive regulation of apoptotic process	GO:043065	10.3	ZBTB16, TNFRSF8, BMP2, TP53, ESR2, IGFBP3
28	anti-apoptosis	GO:006916	10.3	THBS1, FAS, IL10, GSTP1, CDK1, CDKN2D
29	negative regulation of apoptotic process	GO:043066	10.3	XIAP, BCL2, VEGFA, BRAF, GATA6, CASP3
30	positive regulation of cell proliferation	GO:008284	10.3	BIRC5, CGA, T, CDK2, CDK4, FLT1
31	fibroblast growth factor receptor signaling pathway	GO:008543	10.3	FGF3, FGF4, FGF8, FGFR1, FGFR3, CDK1
32	cell-cell signaling	GO:007267	10.2	AR, CGB, CGA, BMP2, LTA, INHA
33	response to toxin	GO:009636	10.1	MGMT, CDH1, CDK1, CYP1B1, CDKN1A, XPA
34	response to drug	GO:042493	10.1	COMT, CYP19A1, CYP17A1, TNF, CCND1, CCNE1
35	organ regeneration	GO:031100	10.0	CDK1, CCNE1, AFP, TGFB1, LIF, CCND1
36	negative regulation of cell proliferation	GO:008285	10.0	BMP2, FGF2, MDM4, APC, IGFBP3, ETS1
37	positive regulation of MAP kinase activity	GO:043406	9.9	VEGFA, FLT1, FGFR1, TNF, KRAS, ERBB2
38	phosphatidylinositol-mediated signaling	GO:048015	9.9	CDKN1B, FGFR1, BUB1B, PCNA, IGF1, CASP9
39	activation of pro-apoptotic gene products	GO:008633	9.9	NKX3-1, CASP8, IFI27, FAS, BAX, BCL2
40	ovarian follicle development	GO:001541	9.9	INHBA, ESR2, KIT, KITLG, BAX, INHA
41	male gonad development	GO:008584	9.9	AR, INHA, INHBA, DMRT1, CYP19A1, NR5A1
42	response to hypoxia	GO:001666	9.8	BCL2, VEGFA, THBS1, LTA, SMAD4, TNF
43	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.8	SOX17, GATA6, TP53, TNF, DMRT1, SMAD4
44	induction of apoptosis by intracellular signals	GO:008629	9.8	HRAS, CASP9, CASP8, CASP3, APAF1, MSH6
45	cell proliferation	GO:008283	9.6	MKI67, PTEN, TNFSF8, SMAD4, PDPN, NANOG
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.6	RARG, RARB, UTF1, LIF, ZFPM2, CGA
47	response to DNA damage stimulus	GO:006974	9.6	RASSF1, TOP2A, BCL2, XIAP, CDKN1A, TP53
48	positive regulation of DNA replication	GO:045740	9.5	HRAS, IGF1, IGF1R, IL3, KITLG, PDGFRA
49	apoptotic process	GO:006915	9.5	PTEN, PHLDA3, KRT18, DFFA, STK17A, PRAME
50	signal transduction	GO:007165	9.2	TNFSF8, TNFRSF8, TXN, PDPN, TDGF1P3, LTA

Molecular functions related to germ cell tumor according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:019901	11.0	CCNA2, CDKN2B, CDKN2D, CDKN2A, GRB7, CCND2
2	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.9	CDKN1B, CASP3, CDKN2A, CDKN1A, CDKN2C, CDKN2B
3	hormone activity	GO:005179	10.7	INHBB, IGF1, IGF2, CGA, CGB, INHA
4	miRNA binding	GO:035198	10.4	POU5F1, DND1, LIN28A, SOX2
5	transcription regulatory region DNA binding	GO:044212	10.4	SOX5, GATA4, TNF, SMAD4, WT1, SOX17
6	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.2	EGFR, TRIM27, KIT, ERBB2, FLT1, PDGFRA
7	enzyme binding	GO:019899	10.2	BIRC5, BIRC7, BCL10, MSH2, AR, CCND1
8	sequence-specific DNA binding transcription factor activity	GO:003700	10.1	ESR2, ESX1, TP53, DMRT1, SMAD4, WT1
9	transcription factor binding	GO:008134	9.8	BCL2, AR, VHL, ZFPM2, CDKN2A, PARP1
10	identical protein binding	GO:042802	9.8	FADD, MDM2, GRB7, FGFR1, INHBA, FLT1
11	protein heterodimerization activity	GO:046982	9.6	SOX5, BRAF, VEGFA, TGFB1, BIRC5, BCL2
12	growth factor activity	GO:008083	9.5	GDF3, INHBC, INHBB, INHBA, INHA, LIF
13	sequence-specific DNA binding	GO:043565	9.3	TOP2A, HIC1, SMAD4, NR5A1, PRDM1, SOX17
14	cytokine activity	GO:005125	9.2	INHBB, INHBA, INHA, LIF, BMP2, IL10
15	protein homodimerization activity	GO:042803	8.6	MAD2L1, SMAD4, SHBG, NDP, TOP2A, TGFB1
16	protein binding	GO:005515	6.5	SMAD4, ETS1, CASP9, CASP8, CASP3, IGF1