MCID: GRM009
MIFTS: 49

Germ Cell Tumors malady

Genetic diseases, Cancer diseases, Rare diseases categories
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Summaries for Germ Cell Tumors

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

MalaCards: Germ Cell Tumors is related to testicular germ cell tumor and teratoma. An important gene associated with Germ Cell Tumors is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways is miRNAs involved in DDR. The compounds ponatinib and vas-a have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and lymph node, and related mouse phenotypes are normal and tumorigenesis.

Description from OMIM:47 273300

Aliases & Classifications for Germ Cell Tumors

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases


Aliases & Descriptions:

germ cell tumors 47


Related Diseases for Germ Cell Tumors

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17GeneCards, 18GeneDecks
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Diseases in the Germ Cell Tumors family:

Malignant Germ Cell Tumor

Diseases related to Germ Cell Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1testicular germ cell tumor32.0FGFR3, STK11, STK10
2teratoma31.5UTF1, DND1, ALPPL2, KIT, CGB
3seminoma31.2ALPPL2, KIT, CGB
4germinoma31.0CGB, KIT
5endodermal sinus tumor31.0ALPPL2, CGB
6testicular cancer31.0STK11, DND1, ALPPL2, CGB
7dysgerminoma30.8TSPY1, KIT
8gonadoblastoma30.6TSPY1, ALPPL2, KIT
9embryonal cancer30.4UTF1, ALPPL2
10nonseminomatous germ cell tumor11.2
11mixed germ cell tumor11.1
12malignant germ cell tumor11.0
13ovarian germ cell tumor11.0
14extragonadal germ cell tumor11.0
15mediastinitis10.9
16central nervous system germ cell tumor10.8
17male germ cell tumor10.8
18choriocarcinoma10.7
19growing teratoma syndrome10.7
20mature teratoma10.7
21male germ cell tumor, somatic10.6
22testicular microlithiasis10.6
23leukemia10.5
24prostatitis10.5
25polyembryoma10.5
26rhabdomyosarcoma10.5
27malignant germ cell tumor of ovary10.5
28klinefelter's syndrome10.5
29cryptorchidism10.5
30teratocarcinoma10.5
31histiocytosis10.5
32pediatric testicular germ cell tumor10.5
33germ cell cancer10.5
34primitive neuroectodermal tumor10.4
35malignant histiocytosis10.4
36malignant cardiac germ cell tumor10.4
37malignant gastric germ cell tumor10.4
38malignant pineal area germ cell neoplasm10.4
39ovarian primitive germ cell tumor10.4
40pediatric ovarian germ cell tumor10.4
41renal cell carcinoma10.4
42sarcoma10.4
43precocious puberty10.4
44neuronitis10.3
45cerebritis10.3
46central nervous system adult germ cell tumor10.3
47cervicitis10.3
48childhood testicular mixed germ cell tumor10.3
49craniopharyngioma10.3
50nephroblastoma10.3

Graphical network of the top 20 diseases related to Germ Cell Tumors:



Diseases related to germ cell tumors

Symptoms for Germ Cell Tumors

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47OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Germ Cell Tumors

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Germ Cell Tumors

Search NIH Clinical Center for Germ Cell Tumors

Genetic Tests for Germ Cell Tumors

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Anatomical Context for Germ Cell Tumors

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33MalaCards
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MalaCards organs/tissues related to Germ Cell Tumors:

33
Testis, Ovary, Lymph node, Testis germ, Pineal, Brain, Testes, Bone, Prostate, Lung, Pituitary, Liver, Bone marrow, Kidney, Endothelial, B cells, Monocytes, Skin, Heart, Eye, Spleen, Temporal lobe, Retina, Spinal cord, Myeloid, Cerebellum, Pancreas

Animal Models for Germ Cell Tumors or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Germ Cell Tumors:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028739.6WNT8A, KIT, GGTA1P, MBD3L2, FGFR3, STK11
2MP:00020069.4FGFR3, GGTA1P, KIT, DND1, STK11

Publications for Germ Cell Tumors

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52PubMed
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Articles related to Germ Cell Tumors:

(show top 50)    (show all 1256)
idTitleAuthorsYear
1
Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group. (24395845)
2014
2
Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience. (22763659)
2013
3
Controversies in the management of stage 1 non-seminomatous germ cell tumors. (23901036)
2013
4
Predictors of CD34(+) Cell Mobilization and Collection in Adult Men With Germ Cell Tumors: Implications for the Salvage Treatment Strategy. (24361054)
2013
5
Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors. (23969837)
2013
6
Multifocality in testicular germ cell tumor (TGCT): what is the significance of this finding? (24318367)
2013
7
Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics. (23423470)
2012
8
Cervical metastasis of germ cell tumors: evaluation, management, complications, and outcomes. (22252920)
2012
9
Mixed germ cell tumor with extensive yolk sac tumor elements in the frontal lobe of an adult. (23326746)
2012
10
Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis. (22962582)
2012
11
Androgen-producing testicular germ cell tumors. (21606422)
2011
12
New prognostic markers and potential therapeutic targets in human testicular germ cell tumors. (22050751)
2011
13
Words of wisdom. Re: management of disseminated nonseminomatous germ cell tumors with risk-based chemotherapy followed by response-guided postchemotherapy surgery. (21524725)
2011
14
ASCO Clinical Practice Guideline on Uses of Serum Tumor Markers in Adult Males With Germ Cell Tumors. (21037873)
2010
15
Prostate tissue within teratoma component of malignant mixed germ cell tumor. (20667927)
2010
16
Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report. (20338049)
2010
17
Primitive neuroectodermal tumors in patients with testicular germ cell tumors usually resemble pediatric-type central nervous system embryonal neoplasms and lack chromosome 22 rearrangements. (20348883)
2010
18
Influence of suboptimal treatment in patients with mediastinal primary nonseminomatous germ cell tumors. (20185939)
2010
19
Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma. (19836053)
2010
20
Radiation therapy for intracranial germ cell tumors. (19329864)
2009
21
Synchronous mixed germ cell tumor of the pineal gland and suprasellar region with a predominant angiomatous component: a diagnostic challenge. (19099195)
2009
22
Recent developments in germ cell tumors of the testes. (18391628)
2008
23
Genetic variants in the 8q24 locus and risk of testicular germ cell tumors. (18373104)
2008
24
Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors. (18515985)
2008
25
Testicular germ cell tumors in mice: new ways to study a genetically complex trait. (18370062)
2008
26
Laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumors: long-term oncologic outcomes. (18303540)
2008
27
Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries. (18287340)
2008
28
First-line high-dose chemotherapy combined with peripheral blood stem cell transplantation for patients with advanced extragonadal germ cell tumors. (17470166)
2007
29
Malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital. (16623016)
2005
30
Analysis of p16INK4A gene promoter in male germ-cell tumors: identification of a new point mutation. (15734211)
2005
31
Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum. (12777991)
2003
32
Prognostic value of tumor size, metastases, extension into bone, and increased tumor marker in children with malignant sacrococcygeal germ cell tumors: a prospective evaluation of 71 patients treated in the German cooperative protocols Maligne Keimzelltumoren (MAKEI) 83/86 and MAKEI 89. (12610174)
2003
33
Estrogen receptor-beta expression in human testicular germ cell tumors. (14555521)
2003
34
Extragonadal germ-cell tumor: a rare differential diagnosis of a cervical lump in a young man. (12199179)
2002
35
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
36
Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. (11358847)
2001
37
Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning. (11908867)
2001
38
Management of malignant pineal germ cell tumors with residual mature teratoma. (11865805)
2001
39
Detection of germ-cell tumor cells in peripheral blood progenitor cell harvests: impact on clinical outcome. (11156214)
2000
40
Retroperitoneal mature teratoma 15 years after initial treatment of testicular mixed germ cell tumor. (11096252)
2000
41
Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome. (10226829)
1999
42
Characterization of multiple 12p rearrangements in testicular germ cell tumor cell line 833K and its subclone 64CP by chromosome microdissection. (9772905)
1998
43
Compliance of clinical stage I nonseminomatous germ cell tumor patients with surveillance. (9720544)
1998
44
Management strategies and outcomes of germ cell tumor patients with very high human chorionic gonadotropin levels. (9552028)
1998
45
Is serum tumor marker half-life a guide to prognosis in metastatic nonseminomatous germ cell tumors? (9329598)
1997
46
Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. (9285688)
1997
47
Serum and tissue levels of manganese superoxide dismutase in testicular germ cell tumors. (8791060)
1996
48
Extragonadal malignant germ cell tumor of the lung. (8283903)
1994
49
Interphase cytogenetics in paraffin embedded sections from human testicular germ cell tumor xenografts and in corresponding cultured cells. (2755080)
1989
50
The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults. (1203848)
1975

Variations for Germ Cell Tumors

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Germ Cell Tumors:

64
id Symbol AA change Variation ID SNP ID
1FGFR3p.Lys650GluVAR_004160
2STK10p.Lys277GluVAR_023827
3STK11p.Gly163AspVAR_033140

Clinvar genetic disease variations for Germ Cell Tumors:

1
id Gene Name Type Significance SNP ID Assembly Location
1KITNM_000222.2(KIT): c.2446G> C (p.Asp816His)single nucleotide variantPathogenicrs121913506GRCh37Chr 4, 55599320: 55599320
2BCL10BCL10, THR161METsingle nucleotide variantPathogenic
3STK11NM_000455.4(STK11): c.488G> A (p.Gly163Asp)single nucleotide variantPathogenicrs137853078GRCh37Chr 19, 1220395: 1220395

Expression for genes affiliated with Germ Cell Tumors

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germ Cell Tumors

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Pathways for genes affiliated with Germ Cell Tumors

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Germ Cell Tumors according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MIR371A, MIR372, MIR373

Compounds for genes affiliated with Germ Cell Tumors

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51PharmGKB, 11DrugBank, 45Novoseek
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Compounds related to Germ Cell Tumors according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ponatinib51 1111.2FGFR3, KIT
2vas-a4510.2KIT, ALPPL2
3pazopanib51 1110.9FGFR3, KIT
4paraffin459.8STK11, ALPPL2, KIT, FGFR3

GO Terms for genes affiliated with Germ Cell Tumors

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16Gene Ontology
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Cellular components related to Germ Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:00989810.2FGFR3, KIT

Biological processes related to Germ Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.3FGFR3, KIT
2positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.2KIT, FGFR3
3somatic stem cell maintenanceGO:03501910.2FGFR3, KIT
4signal transduction by phosphorylationGO:02301410.1KIT, STK10
5protein autophosphorylationGO:04677710.1FGFR3, KIT, STK11, STK10
6positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.9FGFR3, KIT

Products for genes affiliated with Germ Cell Tumors

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Sources for Germ Cell Tumors

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet