MCID: GRM009
MIFTS: 38

Germ Cell Tumors malady

Cancer diseases category

Summaries for Germ Cell Tumors

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

MalaCards: Germ Cell Tumors is related to seminoma and choriocarcinoma. An important gene associated with Germ Cell Tumors is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways is Glycoprotein hormones. The compounds vegf and paraffin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and testis germ, and related mouse phenotypes are reproductive system and digestive/alimentary.

Description from OMIM:46 273300

Aliases & Classifications for Germ Cell Tumors

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46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

germ cell tumors 46


Related Diseases for Germ Cell Tumors

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17GeneCards, 18GeneDecks
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Diseases in the Germ Cell Tumors family:

Malignant Germ Cell Tumor

Diseases related to Germ Cell Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 225)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma31.1ALPPL2, CGA, CGB, KIT, GPC3, POU5F1
2choriocarcinoma31.0CGA, CGB, AFP, ALPPL2, GPC3
3testicular cancer31.0CGA, CGB, ALPPL2, AFP, STK11
4male germ cell tumor, somatic30.9CGA, AFP
5endodermal sinus tumor30.8AFP
6teratocarcinoma30.7POU5F1
7extragonadal germ cell tumor30.6AFP
8sarcoma30.5CGB, KIT
9gonadoblastoma30.4POU5F1, ALPPL2, KIT
10germ cell cancer30.4CGA, ALPPL2, AFP
11testicular germ cell tumor30.4STK10, STK11, FGFR3
12embryonal cancer30.3AFP, GDF3, POU5F1, ALPPL2
13adenocarcinoma30.3STK11, CGB, AFP
14placental site trophoblastic tumor30.3CGA, CGB
15gynecomastia30.3CGA
16lung cancer30.3STK11
17hepatitis30.3AFP, GPC3
18ovarian cancer30.3AFP, CGB, GPC3
19germinoma30.1CGA, CGB, AFP, POU5F1, KIT
20dysgerminoma30.1KIT, POU5F1, AFP, CGA
21adenoma30.1STK11, CGB, CGA
22leydig cell tumor30.1CGA
23pituitary adenoma30.0CGA, POU5F1
24mediastinitis10.9
25central nervous system germ cell tumor10.8
26mature teratoma10.7
27malignant teratoma10.6
28pediatric testicular germ cell tumor10.5
29testicular disease10.5
30nonseminomatous germ cell tumor10.5
31leukemia10.5
32prostatitis10.5
33rhabdomyosarcoma10.5
34klinefelter's syndrome10.4
35cryptorchidism10.4
36histiocytosis10.4
37malignant histiocytosis10.4
38extragonadal germ cell malignant tumor10.4
39pediatric ovarian germ cell tumor10.4
40primitive neuroectodermal tumor10.4
41ovarian germ cell tumor10.4
42malignant cardiac germ cell tumor10.4
43acute leukemia10.4
44giant cell tumor10.4
45malignant gastric germ cell tumor10.4
46malignant pineal area germ cell neoplasm10.4
47ovarian primitive germ cell tumor10.4
48renal cell carcinoma10.4
49cerebritis10.3
50neuronitis10.3

Graphical network of the top 20 diseases related to Germ Cell Tumors:



Diseases related to germ cell tumors

Clinical Features for Germ Cell Tumors

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Sources:
46OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Germ Cell Tumors

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Germ Cell Tumors

Drug clinical trials:

Search ClinicalTrials for Germ Cell Tumors

Search NIH Clinical Center for Germ Cell Tumors

Search CenterWatch for Germ Cell Tumors

Genetic Tests for Germ Cell Tumors

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Anatomical Context for Germ Cell Tumors

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32MalaCards
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MalaCards organs/tissues related to Germ Cell Tumors:

32
Ovary, Testis, Testis germ

Animal Models for Germ Cell Tumors or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Germ Cell Tumors:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538911.0KIT, SALL4, STK11, CGA, AFP, POU5F1
2MP:000538111.0KIT, GPC3, FGFR3, POU5F1, STK11, SALL4
3MP:000287310.8MBD3L2, STK11, POU5F1, GDF3, FGFR3, WNT8A

Publications for Germ Cell Tumors

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Genetic Variations for Germ Cell Tumors

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Germ Cell Tumors:

62
id Symbol AA change Variation ID SNP ID
1FGFR3p.Lys650GluVAR_004160
2STK10p.Lys277GluVAR_023827
3STK11p.Gly163AspVAR_033140

Expression for genes affiliated with Germ Cell Tumors

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germ Cell Tumors

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Pathways for genes affiliated with Germ Cell Tumors

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53Reactome
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Pathways related to Germ Cell Tumors according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.6CGB, CGA

Compounds for genes affiliated with Germ Cell Tumors

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Germ Cell Tumors according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1vegf4411.3STK11, CGA, CGB, AFP, POU5F1, FGFR3
2paraffin4411.2STK11, CGA, AFP, FGFR3, KIT, ALPPL2
3methotrexate44 49 1113.0CGA, CGB, AFP, KIT
4oestriol4411.0AFP, CGB, CGA
5clomiphene citrate4411.0CGA, CGB, AFP
6ifosfamide44 1111.9AFP, CGB, CGA
7bleomycin44 1111.9AFP, CGB, CGA
8mifepristone44 59 28 1113.9CGA, CGB, AFP
9vincristine44 49 1112.8CGB, AFP, KIT
10vas-a4410.8ALPPL2, KIT
11doxorubicin44 49 1112.7CGA, AFP, FGFR3, KIT
12Pazopanib1110.6KIT, FGFR3
13Ponatinib 1110.6KIT, FGFR3
14ctp4410.3CGB, CGA

GO Terms for genes affiliated with Germ Cell Tumors

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16Gene Ontology
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Biological processes related to Germ Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein autophosphorylationGO:04677710.8KIT, FGFR3, STK11, STK10
2negative regulation of smoothened signaling pathwayGO:04587910.6GPC3, FGFR3
3positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.5FGFR3, KIT
4peptide hormone processingGO:01648610.3CGB, CGA

Products for genes affiliated with Germ Cell Tumors

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Germ Cell Tumors

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet