MCID: GRM009
MIFTS: 45

Germ Cell Tumors malady

Cancer category

Summaries for Germ Cell Tumors

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 A germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ cell tumors can be cancerous or... more...

MalaCards: Germ Cell Tumors is related to extragonadal germ cell tumor and teratoma. An important gene associated with Germ Cell Tumors is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Selected targets of Oct-3/4 and Glycoprotein hormones. The compounds methotrexate and lactate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node.

Description from OMIM:47 273300

Aliases & Classifications for Germ Cell Tumors

Sources:
47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

germ cell tumors 47


Related Diseases for Germ Cell Tumors

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Germ Cell Tumors family:

malignant germ cell tumor

Diseases related to Germ Cell Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1extragonadal germ cell tumor31.5CGB5, AFP
2teratoma31.4SALL4, CGA, CGB5, CGB7, CGB, AFP
3germ cell cancer31.3CGA, AFP, ALPPL2
4germinoma31.0CGA, KIT, POU5F1, AFP, CGB, CGB5
5testicular cancer31.0CGA, CGB5, CGB, AFP, ALPPL2
6male germ cell tumor, somatic31.0CGA, AFP
7teratocarcinoma30.7POU5F1
8dysgerminoma30.7CGA, CGB5, AFP, POU5F1, KIT
9cryptorchidism30.6CGA, CGB5, ALPPL2
10gonadoblastoma30.4ALPPL2, KIT, POU5F1
11placental site trophoblastic tumor30.3CGB, CGB5, CGA
12gestational trophoblastic tumor30.3CGA, CGB5, CGB
13adenocarcinoma30.3CGB5, CGB7, CGB, AFP
14adenoma30.3CGA, CGB7, CGB
15gynecomastia30.3CGB5, CGA
16ectopic pregnancy30.1CGA, CGB5, CGB7, CGB
17down syndrome30.1AFP, CGB, CGB7, CGB5, CGA
18azoospermia30.1CGB5, CGA
19testicular germ cell tumor11.4
20nonseminomatous germ cell tumor11.2
21malignant germ cell tumor11.2
22mixed germ cell tumor11.1
23ovarian germ cell tumor11.1
24male germ cell tumor10.9
25ovarian germ cell malignant tumor10.8
26growing teratoma syndrome10.7
27n syndrome10.6
28klinefelter's syndrome10.6
29testicular disease10.6
30testicular microlithiasis10.6
31polyembryoma10.5
32t-cell leukemia10.5
33testis seminoma10.5
34malignant histiocytosis10.4
35malignant cardiac germ cell tumor10.4
36acute t cell leukemia10.4
37extragonadal seminoma10.4
38acute leukemia10.4
39t cell deficiency10.4
40precocious puberty10.4
41angiosarcoma10.3
42extracranial germ cell tumor, childhood10.3
43thymic hyperplasia10.3
44malignant germ cell tumor of the cervix uteri10.3
45pseudo-meigs syndrome10.3
46meigs syndrome10.3
47acute monocytic leukemia10.2
48epithelioid trophoblastic tumor10.2
49sertoli cell tumor10.2
50diabetes insipidus10.2

Graphical network of the top 20 diseases related to Germ Cell Tumors:



Diseases related to germ cell tumors

Clinical Features for Germ Cell Tumors

Sources:
47OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Germ Cell Tumors

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Germ Cell Tumors

Drug clinical trials:

Search ClinicalTrials for Germ Cell Tumors

Search NIH Clinical Center for Germ Cell Tumors

Search CenterWatch for Germ Cell Tumors

Genetic Tests for Germ Cell Tumors

Anatomical Context for Germ Cell Tumors

Sources:
33MalaCards
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MalaCards organs/tissues related to Germ Cell Tumors:

33
Bone marrow, Whole blood, Lymph node, Brain, Spinal cord, Liver, Lung, Breast, Ovary, Placenta, Testis, T cells, B cells, Endothelial, Fetal brain, Temporal lobe, Fetal liver, Fetal lung, Pineal, Pituitary, Testis germ, Testis leydig

Animal Models for Germ Cell Tumors or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Germ Cell Tumors

Sources:
51PubMed
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Articles related to Germ Cell Tumors:

(show top 50)    (show all 755)
idTitleAuthorsYear
1
Relationship between primary and metastatic testicular germ cell tumors: a clinicopathologic analysis of 100 cases. (23856516)
2013
2
The significance of comprehensive staging surgery in malignant ovarian germ cell tumors. (24007946)
2013
3
During twenty years of Cisplatin-based therapy the face of nonseminomatous testicular germ cell tumors is still changing: an evaluation of presentation, management, predictive factors and survival. (23489512)
2013
4
Outcomes of combined modality therapy for patients with stage III or IV mediastinal malignant germ cell tumors. (23553421)
2013
5
Potential role of ventricular tumor markers in CNS germ cell tumors. (23788492)
2013
6
Malignant ovarian germ cell tumors: presentation, survival and second cancer in a population based Norwegian cohort (1953-2009). (24001518)
2013
7
Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors. (23784832)
2013
8
Cervical metastasis of germ cell tumors: evaluation, management, complications, and outcomes. (22252920)
2012
9
Primary intracranial germ cell tumors. (23559987)
2012
10
Effects of N-acetylcystein on bleomycin-induced apoptosis in malignant testicular germ cell tumors. (22562160)
2012
11
Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition. (23251575)
2012
12
Is high-dose chemotherapy superior to conventional chemotherapy as first salvage treatment for patients with metastatic germ cell tumors? (22511419)
2012
13
Pediatric germ cell tumors. (22248970)
2012
14
Updating on the management of germ-cell tumors in disorders of sex development: intratubular germ-cell neoplasia, unclassified type in a 46,XY DSD patient with persistent MA1llerian duct syndrome. (22576304)
2012
15
Residual tumor size and IGCCCG risk classification predict additional vascular procedures in patients with germ cell tumors and residual tumor resection: a multicenter analysis of the German Testicular Cancer Study Group. (22078334)
2012
16
Molecular genetics of testicular germ cell tumors. (22432056)
2012
17
Ovarian germ cell tumors in children: a 20-year retrospective study in a single institution. (21797119)
2011
18
Marijuana use and testicular germ cell tumors. (20925043)
2011
19
Diagnosis, staging, and risk factors: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. (21986222)
2011
20
Do infantile testicular germ cell tumors histogenetically develop from conventional intratubular germ cell neoplasia? (20870431)
2011
21
Management of low-stage nonseminomatous germ cell tumors of testis: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. (21986224)
2011
22
Primitive neuroectodermal tumors in patients with testicular germ cell tumors usually resemble pediatric-type central nervous system embryonal neoplasms and lack chromosome 22 rearrangements. (20348883)
2010
23
High dose chemotherapy as salvage treatment for unresectable late relapse germ cell tumors. (20483152)
2010
24
TI-CE high-dose chemotherapy for patients with previously treated germ cell tumors: results and prognostic factor analysis. (20194867)
2010
25
Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors. (21041627)
2010
26
Loss of heterozygosity of CDKN2A (p16INK4a) and RB1 tumor suppressor genes in testicular germ cell tumors. (22933911)
2010
27
Isochromosome 12p and polysomy 12 in primary central nervous system germ cell tumors: frequency and association with clinicopathologic features. (19801160)
2010
28
Management options for stage 1 nonseminomatous germ cell tumors of the testis. (20535290)
2010
29
Nongerm cell malignancies in testicular germ cell tumors. (19914661)
2010
30
Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation. (19934337)
2009
31
Association of marijuana use and the incidence of testicular germ cell tumors. (19204904)
2009
32
Testicular function in poor-risk nonseminomatous germ cell tumors treated with methotrexate, paclitaxel, ifosfamide, and cisplatin combination chemotherapy. (19136393)
2009
33
Etiologic factors in testicular germ-cell tumors. (19903067)
2009
34
Simultaneous suprasellar and pineal germ cell tumors in five late stage adolescents: endocrinological studies and prolonged follow-up. (19189691)
2008
35
Biology of testicular germ cell tumors. (18925857)
2008
36
Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. (18045648)
2008
37
Histologic type, staging, and distribution of germ cell tumors in Korean adults. (18367106)
2008
38
The influence of conservative surgical practices for malignant ovarian germ cell tumors. (18563734)
2008
39
Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. (16166280)
2005
40
Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1. (15256051)
2004
41
Risk-adapted chemotherapy of germ cell tumors with carboplatin, etoposide and bleomycin for low-risk and cisplatin, etoposide and ifosfamide for high-risk patients. A single-center study. (10971168)
2000
42
A genetic perspective of male germ cell tumors. (9562446)
1998
43
Germ cell tumors of the mediastinum and testis: a comparative immunohistochemical study of 120 cases. (9670832)
1998
44
Is serum tumor marker half-life a guide to prognosis in metastatic nonseminomatous germ cell tumors? (9329598)
1997
45
Importance of a new tumor marker TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors. (9181232)
1997
46
Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor. (8760299)
1996
47
Gynecomastia as a complication of chemotherapy for testicular germ cell tumors. (8973685)
1996
48
Hyperthyroidism in men with germ cell tumors and high levels of beta-human chorionic gonadotropin. (1371235)
1992
49
Immunohistochemical staining of germ cell tumors and intratubular malignant germ cells of the testis using antibody to placental alkaline phosphatase and a monoclonal anti-seminoma antibody. (1646453)
1991
50
The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults. (1203848)
1975

Genetic Variations for Germ Cell Tumors

Expression for genes affiliated with Germ Cell Tumors

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germ Cell Tumors

Search GEO for disease gene expression data for Germ Cell Tumors.

Pathways for genes affiliated with Germ Cell Tumors

Sources:
12EMD Millipore, 54Reactome
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Pathways related to Germ Cell Tumors according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7POU5F1, CGB, CGB7
2
Hide members
10.6CGB, CGA

Compounds for genes affiliated with Germ Cell Tumors

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Germ Cell Tumors according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1methotrexate45 50 1113.4CGA, CGB5, CGB7, CGB, AFP, KIT
2lactate4511.4CGA, CGB5, CGB7, CGB, AFP, KIT
3progesterone45 60 29 11 2415.3CGA, CGB5, CGB7, CGB, AFP, KIT
4testosterone45 60 11 2414.3CGA, CGB5, CGB7, CGB, AFP, KIT
5vegf4511.3CGA, CGB5, CGB, AFP, POU5F1, KIT
6oestriol4511.3AFP, CGB, CGB7, CGB5, CGA
7bleomycin45 1112.3CGA, CGB5, CGB7, CGB, AFP
8etoposide45 50 60 1114.3CGA, CGB5, CGB7, CGB, AFP
9estradiol45 11 2413.2CGA, CGB5, CGB7, CGB, AFP
10paraffin4511.2CGA, CGB5, AFP, KIT, ALPPL2
11clomiphene citrate4511.2AFP, CGB, CGB5, CGA
12ctp4511.2CGA, CGB5, CGB7, CGB
13cisplatin45 50 60 1114.2CGA, CGB5, CGB7, CGB, AFP
14ifosfamide45 1112.2CGA, CGB5, CGB, AFP
15mifepristone45 60 29 1114.2CGA, CGB5, CGB, AFP
16vincristine45 50 1113.2CGB5, CGB, AFP, KIT
17cyclophosphamide45 50 1113.2CGA, CGB5, CGB, AFP
18thyroxine45 2412.2CGA, CGB7, CGB, AFP
19gnrh4511.1CGB, CGB7, CGB5, CGA
20diethylstilbestrol45 29 1113.1AFP, CGB5, CGA
2111-ketotestosterone4511.0CGB5, CGA
22vinblastine45 50 1113.0CGA, CGB5, AFP
23androstenedione45 2412.0CGA, CGB5, CGB
24organon4511.0CGB5, CGA
25trilostane45 1111.9CGB5, CGA
26estradiol benzoate4510.9CGB5, CGA
2717-hydroxypregnenolone4510.9CGA, CGB5
28leuprolide45 60 29 1113.9CGA, CGB5
29doxorubicin45 50 1112.9CGA, CGB5, AFP, KIT
30dihydroprogesterone4510.9CGB5, CGA
31vas-a4510.8ALPPL2, KIT
32cetrorelix45 29 1112.8CGA, CGB5
338-bromo-cyclic amp4510.8CGA, CGB5
3422r-hydroxycholesterol45 2911.8CGB5, CGA
35buserelin45 29 1112.6CGA, CGB5
36lutein4510.6CGB5, CGA
37leuprolide acetate4510.5CGA, CGB5
38actinomycin d4510.5KIT, AFP, CGB5, CGA

GO Terms for genes affiliated with Germ Cell Tumors

Sources:
16Gene Ontology
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Biological processes related to Germ Cell Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.6CGB, CGA

Products for genes affiliated with Germ Cell Tumors

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Germ Cell Tumors

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet