MCID: GRM004
MIFTS: 41

Germinoma malady

Rare diseases, Cancer diseases categories

Summaries for Germinoma

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Wikipedia:63 A germinoma is a type of germ cell tumor, which is not differentiated upon examination. It may be benign... more...

MalaCards based summary: Germinoma, also known as extragonadal germinoma, is related to precocious puberty and teratoma. An important gene associated with Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Metabolism of steroid hormones and vitamin D and Selected targets of Oct 3 4. The compounds oestriol and ctp have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and spinal cord.

Disease Ontology:9 A germ cell cancer that lacks histologic differentiation. it usually refers to a tumor in the brain.

Aliases & Classifications for Germinoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 34MESH via Orphanet, 61UMLS via Orphanet
See all sources

Germinoma, Aliases & Descriptions:

Name: Germinoma 9 41 11 43 60
Extragonadal Germinoma 41 47
 
Pineal Germinoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 47 
Rare tumors


External Ids:

Disease Ontology9 DOID:3304
NCIt38 C3753
MeSH33 D018237
SNOMED-CT55 28307001, 154603000
Orphanet47 182127
MESH via Orphanet34 D018237
UMLS via Orphanet61 C0206660

Related Diseases for Germinoma

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Diseases related to Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1precocious puberty30.7CGA, CYP21A2
2teratoma30.6POU5F1, CGB, CGA
3hypopituitarism30.5CGA, CYP21A2
4hyperprolactinemia30.3CGB, CGA
5prolactinoma30.0CGA, CGB
6seminoma30.0INHA, POU5F1, CGB, CGA
7choriocarcinoma29.8INHA, CGB, CGA
8klinefelter's syndrome29.8CYP21A2, INHA, CGB, CGA
9dysgerminoma29.8CGA, POU5F1, INHA
10testicular cancer29.6CGA, CGB, INHA
11down syndrome29.6CGA, CGB, INHA
12pituitary adenoma29.5CGA, POU5F1, INHA
13adenoma29.3CYP21A2, INHA, CGB, CGA
14central nervous system germinoma10.6
15cerebritis10.5
16adrenal rest tumor10.4CYP21A2
17diabetes insipidus10.4
18mediastinitis10.4
19brain germinoma10.4
20pineoblastoma10.3POU5F1
21pineal region germinoma10.3
22cervicitis10.3
23lymphocytic hypophysitis10.3
24epithelioid trophoblastic tumor10.3INHA
25adult central nervous system germinoma10.2
26childhood brain germinoma10.2
27gestational trophoblastic tumor10.2CGB, CGA
28childhood central nervous system germinoma10.2
29peritonitis10.2
30mixed germ cell tumor10.2
31ectopic pregnancy10.2CGB, CGA
32luteoma10.2CYP21A2, CGA
33anovulation10.2CGA, CYP21A2
34neural tube defects10.2CGA, CGB
35polycystic ovary syndrome10.1CYP21A2, CGA
36hypospadias10.1CYP21A2, CGA
37astrocytoma10.1
38mature teratoma10.1
39male infertility10.1CYP21A2, CGA
40hyperandrogenism10.1CGA, CYP21A2
41endodermal sinus tumor10.1INHA, CGB
42hyperthyroidism10.1CGA, CGB
43adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency10.1CYP21A2, INHA
44azoospermia10.1CGA, CYP21A2
45trophoblastic neoplasm10.0INHA, CGA
46medulloblastoma10.0
47obsessive-compulsive disorder10.0
48peutz-jeghers syndrome10.0
49proteus syndrome, somatic10.0
50hydrocephalus10.0

Graphical network of the top 20 diseases related to Germinoma:



Diseases related to germinoma

Symptoms for Germinoma

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Drugs & Therapeutics for Germinoma

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Drug clinical trials:

Search ClinicalTrials for Germinoma

Search NIH Clinical Center for Germinoma

Genetic Tests for Germinoma

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Anatomical Context for Germinoma

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MalaCards organs/tissues related to Germinoma:

31
Pineal, Brain, Spinal cord, Medulla oblongata, Pituitary, Bone, Thalamus, Testes, Temporal lobe, Bone marrow, Heart

Animal Models for Germinoma or affiliated genes

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Publications for Germinoma

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Articles related to Germinoma:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
Malignant transformation of germinoma 14 years after onset: Favorable efficacy of oral etoposide. (25712128)
2015
2
Teaching Neuroimages: Basal Ganglia Germinoma with Hemiatrophy. (25795465)
2015
3
Intensive chemotherapy followed by reduced-dose radiotherapy for biopsy-proven CNS germinoma with elevated beta-human chorionic gonadotropin. (24488445)
2014
4
A rare case of multifocal intramedullary germinoma in cervical spinal cord. (24902643)
2014
5
Primary intramedullary spinal cord germinoma. (23432481)
2013
6
Effective radiotherapy cured cauda equina syndrome caused by remitted intracranial germinoma depositing. (23084725)
2012
7
Precocious puberty due to human chorionic gonadotropin secreting germinoma. (23560009)
2012
8
Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the ventricular trigone. (22347677)
2012
9
A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma. (21046314)
2010
10
Germinoma of basal ganglia in female: case report and review of the literature. (19082612)
2009
11
Brain germinoma in a young adult man with suspicion of fatal neglect. (19465813)
2009
12
Use of 11C-methionine positron emission tomography in basal germinoma: assessment of treatment response and residual tumor. (19296116)
2009
13
Bilateral germinoma of the basal ganglia. (16700048)
2008
14
C-kit gene mutation: common and widely distributed in intracranial germinomas. (16572634)
2006
15
Primary germinoma of the orbit. (17152667)
2005
16
Breaking down barriers to treat a patient with a germinoma: a case study. (15366544)
2004
17
High uptake on 11C-methionine positron emission tomographic scan of basal ganglia germinoma with cerebral hemiatrophy. (14561627)
2003
18
Primary intramedullary spinal cord germinoma: case report. (12814257)
2003
19
Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central nervous system germinoma. (14595717)
2003
20
CNS germinoma in a boy with simple virilizing 21-hydroxylase deficiency and precocious puberty. (11926207)
2002
21
Bilateral metachronous germinoma of the basal ganglia occurring long after total removal of a mature pineal teratoma: case report. (11841731)
2002
22
Usefulness of gallium-67 scintigraphy in neurohypophyseal germinoma. (10949440)
2000
23
Metastatic spinal intramedullary germinoma with elevated cerebrospinal fluid chorionic gonadotropin: a case report. (10717404)
2000
24
The role of chemotherapy in intracranial germinoma: a case report. (10442196)
1999
25
Metachronous neurohypophyseal germinoma occurring 8 years after total resection of pineal mature teratoma. (9457272)
1998
26
Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. (9420074)
1998
27
Radiation therapy for histologically confirmed primary central nervous system germinoma. (9276355)
1997
28
Simultaneous presentation of pineal germinoma and testicular seminoma. (8977797)
1996
29
Intramedullary spinal cord germinoma: case report and review of the literature. (8747968)
1996
30
Aromatase expression in human germinomas with possible biological effects. (8530631)
1995
31
Complete disappearance of giant intracranial germinoma after irradiation. (8927248)
1995
32
Germinoma arising in the basal ganglia in early stage: CT and MR findings. (8850373)
1995
33
Intramedullary spinal cord germinoma. (8553123)
1995
34
A phase II trial of preirradiation carboplatin in newly diagnosed germinoma of the central nervous system. (8039122)
1994
35
Basal ganglia germinoma with crossed cerebellar diaschisis--case report. (7506817)
1993
36
The short-term effect of low-dose radiation on intracranial germinoma. A pathologic study. (1562979)
1992
37
Recurrent intracranial germinoma refractory to conventional irradiation: effective chemotherapy consisting of cisplatin and etoposide--case report. (1381062)
1992
38
Intracranial germinoma: report of seven cases. (2206859)
1990
39
Germinoma of the pineal region. (2277013)
1990
40
Hypothalamic and basal forebrain germinoma presenting with amnesia and hyperphagia. (2922668)
1989
41
Spontaneously ruptured pineal epidermoid cyst associated with a thalamic germinoma. (2747874)
1989
42
Granulomatous inflammation in pineal germinoma. A cause of diagnostic failure at stereotaxic brain biopsy. (3046394)
1988
43
Endocrine function and growth in children with CNS tumors--with special emphasis on germinoma. (3146879)
1988
44
Germinoma in the cerebellopontine angle. (3876410)
1985
45
Systemic metastases in primary intracranial germinoma. Case report and literature review. (3995478)
1985
46
Microsurgery of teratoma and germinoma involving the diencephalon and the brain stem. (6657078)
1983
47
Suprasellar germinoma. Unresolved problems in diagnosis, pathogenesis, and management. (6624780)
1983
48
Suprasellar germinoma in association with Klinefelter's syndrome. Case report. (6847901)
1983
49
Diagnosis and treatment of suprasellar germinoma. (290221)
1979
50
Presence of lymphocyte membrane surface markers on "small cells" in a pineal germinoma. (315205)
1979

Variations for Germinoma

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Expression for genes affiliated with Germinoma

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Search GEO for disease gene expression data for Germinoma.

Pathways for genes affiliated with Germinoma

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Pathways related to Germinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CGA, CYP21A2
2
Show member pathways
8.7CGA, CGB, INHA
3
Show member pathways
8.7CGA, CGB, INHA

Compounds for genes affiliated with Germinoma

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Compounds related to Germinoma according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1oestriol439.9CGA, CGB
2ctp439.8CGB, CGA
3nafarelin43 59 28 1212.8CGA, CYP21A2
4ifosfamide43 1210.8CGA, CGB
517-hydroxypregnenolone439.8CYP21A2, CGA
611 deoxycortisol439.8CGA, CYP21A2
7leuprolide acetate439.8CGA, CYP21A2
817-hydroxyprogesterone43 2410.8CGA, CYP21A2
9bleomycin43 1210.7CGB, CGA
10dehydroepiandrosterone sulfate439.7CYP21A2, CGA
1117beta-hydroxysteroid439.7CYP21A2, CGA
12phenytoin43 49 28 1212.7CGA, CYP21A2
13mifepristone43 28 59 1212.7CGA, CGB
14dihydrotestosterone43 28 24 1212.5CYP21A2, CGA
15cloprostenol43 2810.5CGA, INHA
16methotrexate49 43 1211.5CGA, CGB
17carbon439.4CGA, CYP21A2
18cyclophosphamide43 49 1211.4CGB, CGA
19clomiphene citrate439.4CYP21A2, CGB, CGA
20thyroxine43 2410.4CYP21A2, CGB, CGA
21biotin43 24 1211.3INHA, CYP21A2
22agarose439.2INHA, CYP21A2
23norepinephrine43 24 1211.1CGA, POU5F1, CYP21A2
24vegf439.1CGA, CGB, POU5F1
253beta-hydroxysteroid439.0CYP21A2, INHA, CGA
26ribonucleic acid439.0CGA, INHA, CYP21A2
27cyclic amp43 249.9INHA, CGB, CGA
28forskolin43 49 1210.9CYP21A2, INHA, CGA
29steroid438.9CGA, INHA, CYP21A2
30alanine438.9INHA, CGB, CGA
31acth438.8INHA, CYP21A2
32androstenedione43 249.6CGA, CGB, INHA, CYP21A2
33gnrh438.6CGA, CGB, INHA, CYP21A2
34estradiol43 24 1210.6CGA, CGB, INHA, CYP21A2
35progesterone43 28 59 24 1212.6CYP21A2, INHA, CGB, CGA
36testosterone43 59 24 1211.5CYP21A2, INHA, CGB, CGA
37estrogen438.5CYP21A2, INHA, CGB, CGA

GO Terms for genes affiliated with Germinoma

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Biological processes related to Germinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:00164869.4CGA, CGB
2signal transductionGO:00071658.7CGA, CGB, INHA
3cell-cell signalingGO:00072678.4CGA, CGB, INHA

Molecular functions related to Germinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.7CGA, CGB, INHA

Products for genes affiliated with Germinoma

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Sources for Germinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet