MCID: GRM004
MIFTS: 45

Germinoma malady

Rare diseases, Cancer diseases categories
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Summaries for Germinoma

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Wikipedia:65 A germinoma is a type of germ cell tumor, which is not differentiated upon examination. It may be benign... more...

MalaCards based summary: Germinoma is related to precocious puberty and teratoma. An important gene associated with Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Metabolism of steroid hormones and vitamin D and Selected targets of Oct 3 4. The compounds oestriol and ctp have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and spinal cord.

Disease Ontology:8 A germ cell cancer that lacks histologic differentiation. it usually refers to a tumor in the brain.

Aliases & Classifications for Germinoma

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Germinoma, Aliases & Descriptions:

Name: Germinoma 8 42 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:3304
MeSH34 D018237
SNOMED-CT57 28307001, 154603000
NCIt39 C3753

Related Diseases for Germinoma

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Diseases related to Germinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1precocious puberty30.7CGA, CYP21A2
2teratoma30.6POU5F1, CGB, CGA
3hypopituitarism30.5CGA, CYP21A2
4hyperprolactinemia30.3CGB, CGA
5prolactinoma30.0CGA, CGB
6seminoma30.0INHA, POU5F1, CGB, CGA
721-hydroxylase deficiency29.9CYP21A2, INHA
8choriocarcinoma29.8INHA, CGB, CGA
9klinefelter's syndrome29.8CYP21A2, INHA, CGB, CGA
10dysgerminoma29.8CGA, POU5F1, INHA
11testicular cancer29.6CGA, CGB, INHA
12down syndrome29.6CGA, CGB, INHA
13pituitary adenoma29.5CGA, POU5F1, INHA
14adenoma29.3CYP21A2, INHA, CGB, CGA
15central nervous system germinoma10.6
16cerebritis10.5
17diabetes insipidus10.4
18adrenal rest tumor10.4CYP21A2
19germ cell tumors10.4
20mediastinitis10.4
21brain germinoma10.4
22pineoblastoma10.4POU5F1
23epithelioid trophoblastic tumor10.3INHA
24pineal region germinoma10.3
25cervicitis10.3
26lymphocytic hypophysitis10.3
27adult central nervous system germinoma10.2
28childhood brain germinoma10.2
29gestational trophoblastic tumor10.2CGB, CGA
30ectopic pregnancy10.2CGB, CGA
31luteoma10.2CYP21A2, CGA
32panhypopituitarism10.2
33peritonitis10.2
34mixed germ cell tumor10.2
35pregnancy loss10.2CGA, CGB
36anovulation10.2CGA, CYP21A2
37neural tube defects10.2CGA, CGB
38polycystic ovary syndrome10.1CYP21A2, CGA
39hypospadias10.1CYP21A2, CGA
40childhood central nervous system germinoma10.1
41astrocytoma10.1
42mature teratoma10.1
43meningioma10.1
44extragonadal germinoma10.1
45male infertility10.1CYP21A2, CGA
46hyperandrogenism10.1CGA, CYP21A2
47endodermal sinus tumor10.1INHA, CGB
48hyperthyroidism10.1CGA, CGB
49azoospermia10.1CGA, CYP21A2
50trophoblastic neoplasm10.1INHA, CGA

Graphical network of the top 20 diseases related to Germinoma:



Diseases related to germinoma

Symptoms for Germinoma

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Drugs & Therapeutics for Germinoma

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Drug clinical trials:

Search ClinicalTrials for Germinoma

Search NIH Clinical Center for Germinoma

Genetic Tests for Germinoma

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Anatomical Context for Germinoma

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MalaCards organs/tissues related to Germinoma:

32
Pineal, Brain, Spinal cord, Medulla oblongata, Pituitary, Bone, Thalamus, Testes, Temporal lobe, Bone marrow, Heart, Testis

Animal Models for Germinoma or affiliated genes

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Publications for Germinoma

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Articles related to Germinoma:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Intensive chemotherapy followed by reduced-dose radiotherapy for biopsy-proven CNS germinoma with elevated beta-human chorionic gonadotropin. (24488445)
2014
2
A rare case of multifocal intramedullary germinoma in cervical spinal cord. (24902643)
2014
3
Primary intramedullary spinal cord germinoma. (23432481)
2013
4
Effective radiotherapy cured cauda equina syndrome caused by remitted intracranial germinoma depositing. (23084725)
2012
5
Precocious puberty due to human chorionic gonadotropin secreting germinoma. (23560009)
2012
6
Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the ventricular trigone. (22347677)
2012
7
A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma. (21046314)
2010
8
Germinoma of basal ganglia in female: case report and review of the literature. (19082612)
2009
9
Brain germinoma in a young adult man with suspicion of fatal neglect. (19465813)
2009
10
Use of 11C-methionine positron emission tomography in basal germinoma: assessment of treatment response and residual tumor. (19296116)
2009
11
Bilateral germinoma of the basal ganglia. (16700048)
2008
12
C-kit gene mutation: common and widely distributed in intracranial germinomas. (16572634)
2006
13
Primary germinoma of the orbit. (17152667)
2005
14
Breaking down barriers to treat a patient with a germinoma: a case study. (15366544)
2004
15
High uptake on 11C-methionine positron emission tomographic scan of basal ganglia germinoma with cerebral hemiatrophy. (14561627)
2003
16
Primary intramedullary spinal cord germinoma: case report. (12814257)
2003
17
Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central nervous system germinoma. (14595717)
2003
18
Pineal germinoma followed by hematogenous metastases. (12602751)
2003
19
CNS germinoma in a boy with simple virilizing 21-hydroxylase deficiency and precocious puberty. (11926207)
2002
20
Bilateral metachronous germinoma of the basal ganglia occurring long after total removal of a mature pineal teratoma: case report. (11841731)
2002
21
Usefulness of gallium-67 scintigraphy in neurohypophyseal germinoma. (10949440)
2000
22
Metastatic spinal intramedullary germinoma with elevated cerebrospinal fluid chorionic gonadotropin: a case report. (10717404)
2000
23
The role of chemotherapy in intracranial germinoma: a case report. (10442196)
1999
24
Metachronous neurohypophyseal germinoma occurring 8 years after total resection of pineal mature teratoma. (9457272)
1998
25
Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. (9420074)
1998
26
Radiation therapy for histologically confirmed primary central nervous system germinoma. (9276355)
1997
27
Simultaneous presentation of pineal germinoma and testicular seminoma. (8977797)
1996
28
Intramedullary spinal cord germinoma: case report and review of the literature. (8747968)
1996
29
Aromatase expression in human germinomas with possible biological effects. (8530631)
1995
30
Complete disappearance of giant intracranial germinoma after irradiation. (8927248)
1995
31
Germinoma arising in the basal ganglia in early stage: CT and MR findings. (8850373)
1995
32
Intramedullary spinal cord germinoma. (8553123)
1995
33
A phase II trial of preirradiation carboplatin in newly diagnosed germinoma of the central nervous system. (8039122)
1994
34
Basal ganglia germinoma with crossed cerebellar diaschisis--case report. (7506817)
1993
35
The short-term effect of low-dose radiation on intracranial germinoma. A pathologic study. (1562979)
1992
36
Recurrent intracranial germinoma refractory to conventional irradiation: effective chemotherapy consisting of cisplatin and etoposide--case report. (1381062)
1992
37
Intracranial germinoma: report of seven cases. (2206859)
1990
38
Germinoma of the pineal region. (2277013)
1990
39
Germinoma originating in the basal ganglia. Report of a case showing unusual appearance on MRI. (2287389)
1990
40
Hypothalamic and basal forebrain germinoma presenting with amnesia and hyperphagia. (2922668)
1989
41
Spontaneously ruptured pineal epidermoid cyst associated with a thalamic germinoma. (2747874)
1989
42
Granulomatous inflammation in pineal germinoma. A cause of diagnostic failure at stereotaxic brain biopsy. (3046394)
1988
43
Endocrine function and growth in children with CNS tumors--with special emphasis on germinoma. (3146879)
1988
44
Germinoma in the cerebellopontine angle. (3876410)
1985
45
Systemic metastases in primary intracranial germinoma. Case report and literature review. (3995478)
1985
46
Microsurgery of teratoma and germinoma involving the diencephalon and the brain stem. (6657078)
1983
47
Suprasellar germinoma. Unresolved problems in diagnosis, pathogenesis, and management. (6624780)
1983
48
Suprasellar germinoma in association with Klinefelter's syndrome. Case report. (6847901)
1983
49
Diagnosis and treatment of suprasellar germinoma. (290221)
1979
50
Presence of lymphocyte membrane surface markers on "small cells" in a pineal germinoma. (315205)
1979

Variations for Germinoma

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Expression for genes affiliated with Germinoma

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Expression patterns in normal tissues for genes affiliated with Germinoma

Search GEO for disease gene expression data for Germinoma.

Pathways for genes affiliated with Germinoma

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Pathways related to Germinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CYP21A2, CGA
29.4POU5F1, CGB
3
Show member pathways
8.7CGA, CGB, INHA
4
Show member pathways
8.7CGA, CGB, INHA

Compounds for genes affiliated with Germinoma

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Compounds related to Germinoma according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1oestriol449.9CGA, CGB
2ctp449.8CGB, CGA
3nafarelin44 61 28 1112.8CGA, CYP21A2
4ifosfamide44 1110.8CGA, CGB
517-hydroxypregnenolone449.8CYP21A2, CGA
611 deoxycortisol449.8CGA, CYP21A2
7leuprolide acetate449.8CGA, CYP21A2
817-hydroxyprogesterone44 2410.8CGA, CYP21A2
9bleomycin44 1110.7CGB, CGA
10dehydroepiandrosterone sulfate449.7CYP21A2, CGA
1117beta-hydroxysteroid449.7CYP21A2, CGA
12phenytoin44 50 28 1112.7CGA, CYP21A2
13mifepristone44 28 61 1112.7CGA, CGB
14dihydrotestosterone44 28 24 1112.5CYP21A2, CGA
15cloprostenol44 2810.5CGA, INHA
16methotrexate50 44 1111.5CGA, CGB
17carbon449.4CGA, CYP21A2
18cyclophosphamide44 50 1111.4CGB, CGA
19clomiphene citrate449.4CYP21A2, CGB, CGA
20thyroxine44 2410.4CYP21A2, CGB, CGA
21biotin44 24 1111.3INHA, CYP21A2
22agarose449.2INHA, CYP21A2
23norepinephrine44 24 1111.1CGA, POU5F1, CYP21A2
24vegf449.1CGA, CGB, POU5F1
253beta-hydroxysteroid449.0CYP21A2, INHA, CGA
26ribonucleic acid449.0CGA, INHA, CYP21A2
27cyclic amp44 249.9INHA, CGB, CGA
28forskolin44 50 1110.9CYP21A2, INHA, CGA
29steroid448.9CGA, INHA, CYP21A2
30alanine448.9INHA, CGB, CGA
31acth448.8INHA, CYP21A2
32androstenedione44 249.6CGA, CGB, INHA, CYP21A2
33gnrh448.6CGA, CGB, INHA, CYP21A2
34estradiol44 24 1110.6CGA, CGB, INHA, CYP21A2
35progesterone44 28 61 24 1112.6CYP21A2, INHA, CGB, CGA
36testosterone44 61 24 1111.5CYP21A2, INHA, CGB, CGA
37estrogen448.5CYP21A2, INHA, CGB, CGA

GO Terms for genes affiliated with Germinoma

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Biological processes related to Germinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.4CGA, CGB
2signal transductionGO:0071658.7CGA, CGB, INHA
3cell-cell signalingGO:0072678.4CGA, CGB, INHA

Molecular functions related to Germinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.7CGA, CGB, INHA

Products for genes affiliated with Germinoma

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Sources for Germinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet