Germinoma malady

Wikipedia: A germinoma is a type of germ cell tumor which is not differentiated upon examination. It may be benign...⁴⁴ more...

MalaCards: Germinoma is related to central nervous system germinoma and 21-hydroxylase deficiency. An important gene associated with Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Melanocyte Development and Pigmentation and Selected targets of Oct-3/4. The compounds vincristine and ctp have been mentioned in the context of this disorder. Affiliated tissues include whole blood, spinal cord and medulla oblongata, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

germinoma 30 8 32 43

Diseases related to germinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 339)

id	Related Disease	Score	Top Affiliating Genes
1	central nervous system germinoma	32.3	CGB, ALPP, POU5F1
2	21-hydroxylase deficiency	28.2	INHA, CYP21A2
3	central nervous system germ cell tumor	28.2	CGB, PDPN, AFP
4	diabetes insipidus	27.6	CGA, CGB, AVP, CYP21A2, PRL, AFP
5	lymphocytic hypophysitis	27.0	ALPP, PRL
6	virilization	27.0	CGA, CGB5, CYP19A1, CYP21A2, AFP
7	sinusitis	25.1	BAX, CGA, CGB7, AVP, ALPP, TRIM26
8	cerebritis	25.1	KITLG, BCL2, BAX, CGA, CGB5, AVP
9	teratoma	24.5	KIT, BCL2, BAX, CGA, CGB, CGB5
10	glioblastoma	24.1	KIT, KITLG, BCL2, BAX, CD44, APC
11	germ cell tumor	23.3	KIT, KITLG, BCL2, BAX, CGA, CGB
12	cholesterol	23.2	KITLG, BAX, CGA, CGB5, CD44, ALPP
13	seminoma	22.2	KIT, KITLG, BCL2, BAX, CGA, CGB
14	carcinoma	19.0	KIT, KITLG, BCL2, BAX, CGA, CGB
15	ovarian mixed germ cell neoplasm	13.7	CGA, AFP
16	cutis marmorata telangiectatica congenita	13.7	CGA, AFP
17	polyembryoma	13.7	CGA, AFP
18	habitual abortion	13.7	CGB, CGB5
19	triploidy	13.6	CGA, CGB
20	malignant germ cell tumor	13.6	CGB5, AFP
21	adrenal rest tumor	13.6	CGB, CYP21A2
22	testicular microlithiasis	13.6	CGB, AFP
23	dysgerminoma of ovary	13.6	KIT, ALPP
24	malignant sertoli cell tumor	13.6	CGB5, ALPP, AFP
25	ulcerative stomatitis	13.6	CGB5, CGB7
26	extragonadal germ cell tumor	13.6	CGB, CGB5, AFP
27	5-alpha reductase deficiency	13.6	CGA, CGB5
28	hydrocele	13.5	CGA, CGB5, AFP
29	anencephaly	13.5	CGA, CGB5, AFP
30	trophoblastic neoplasm	13.5	CGA, CGB5, INHA
31	anorchia	13.5	CGA, CGB5
32	mixed ductal-endocrine carcinoma	13.5	CGB, CGB5, CGB7
33	edwards syndrome	13.5	CGA, INHA, AFP
34	gestational choriocarcinoma	13.5	CGB5, CGB7, ALPP
35	germ cell cancer	13.5	CGA, ALPP, AFP
36	luteoma	13.5	CGA, CYP21A2, TSPY1
37	mature teratoma	13.5	CGA, CGB, ALPP, AFP
38	cryptococcosis	13.5	CGB, CGB5, CGB7
39	placental site trophoblastic tumor	13.4	CGA, CGB5, PSG1
40	thyrotoxicosis	13.4	CGA, CGB7, ALPP
41	epithelioid trophoblastic tumor	13.4	CGA, CGB5, INHA, ALPP
42	indolent systemic mastocytosis	13.4	KIT, KITLG
43	testicular neoplasm	13.4	KIT, INHA, ALPP, AFP
44	waardenburg's syndrome	13.4	KIT, ALPI, ALPP
45	sacrococcygeal teratoma	13.4	CGA, CGB7, POU5F1, AFP
46	gestational trophoblastic tumor	13.4	CGA, CGB, CGB5, PSG1
47	endodermal sinus tumor	13.4	CGA, ALPP, TRIM26, AFP
48	sycp3-related pregnancy loss, susceptibility to	13.4	CGA, CGB, CGB5, CGB7
49	aggressive systemic mastocytosis	13.3	KIT, KITLG
50	turner syndrome	13.3	CGA, CGB, CYP21A2, TSPY1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to germinoma:

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MGI Mouse Phenotypes related to germinoma:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.1	DMRT1, AFP, INHA
2	liver/biliary system phenotype	MP:0005370	9.0	POU5F1, KIT, CYP19A1, DHCR7, PRL
3	normal phenotype	MP:0002873	8.8	CD44, ALPP, CYP19A1, POU5F1, AVP, INHA
4	immune system phenotype	MP:0005387	8.7	PDPN, INHA, KIT, PRL, CYP19A1
5	pigmentation phenotype	MP:0001186	8.3	KIT, KITLG, BCL2, APC, CYP19A1
6	hearing/vestibular/ear phenotype	MP:0005377	8.1	APC, KIT, KITLG, BCL2, CYP19A1, BAX
7	mortality/aging	MP:0010768	7.9	POU5F1, AVP, AFP, DHCR7, PDPN, KITLG
8	behavior/neurological phenotype	MP:0005386	7.6	POU5F1, PRL, PDPN, CYP19A1, DHCR7, CD44
9	muscle phenotype	MP:0005369	7.6	APC, CYP19A1, TSPY1, BAX, CD44, KIT
10	reproductive system phenotype	MP:0005389	7.4	CGA, CD44, CDH1, INHA, APC, ALPP
11	digestive/alimentary phenotype	MP:0005381	7.3	POU5F1, PDPN, APC, KIT, KITLG, BCL2
12	tumorigenesis	MP:0002006	7.2	KITLG, BCL2, CD44, CDH1, INHA, APC
13	cardiovascular system phenotype	MP:0005385	6.8	CD44, BCL2, CDH1, KITLG, KIT, INHA
14	integument phenotype	MP:0010771	6.7	POU5F1, PRL, PDPN, CYP19A1, KIT, KITLG
15	nervous system phenotype	MP:0003631	6.3	POU5F1, CD44, AVP, CYP19A1, DHCR7, PRL
16	growth/size phenotype	MP:0005378	6.1	BAX, CYP19A1, BCL2, CD44, CDH1, KITLG
17	homeostasis/metabolism phenotype	MP:0005376	5.3	APC, PRL, DHCR7, PDPN, KIT, KITLG

Articles related to germinoma:

(show top 50)    (show all 53)

id	Title	Authors	Year	Affiliating Genes
1	HESRG: a novel biomarker for intracranial germinoma a nd embryonal carcinoma. (21861197)	Wanggou S.... Ren C.	2012	ESRG
2	Germinoma presenting as a fourth cranial nerve palsy in a patient with adenomatous polyposis coli (APC) gene mutation. (21315632)	Lima B.R.... Rychwalski P.J.	2011	APC
3	Recurrent pure CNS germinoma with markedly elevated s erum and cerebrospinal fluid human chorionic gonadotropin-beta (HCGI^). (20949592)	Khatua S.... Finlay J.L.	2011	CGB
4	Two cases of intracranial germinoma showing a cell ar rangement mimicking carcinoma. (20073098)	Ohta Y.... Ota H.	2010	ALPP
5	Optic nerve and chiasmal germinoma. (19300174)	Rath S.... Mod H.	2009	ALPP
6	Management of central nervous system germinoma: proposal for a modern strategy. (19329866)	Shibamoto Y.	2009	CGB
7	Long term outcomes in patients with intracranial germinomas: a single institution experience of irradiation with or without chemotherapy. (18286232)	Kawabata Y.... Hashimoto N.	2008	CGB5
8	Malignant intracranial germinoma in Smith-Lemli-Opitz syndrome: cholesterol homeostasis possibly connecting morphogenesis and cancer development. (18776762)	Oslejskova H.... Valik D.	2008	DHCR7
9	Pineal germinoma with a prominent epithelioid cell granuloma component: case report. (19106497)	Mori R.... Abe T.	2008	ALPP
10	Neurohypophyseal granulomatous germinoma invading the right cavernous sinus: case report and review of the literature. (17627146)	Fukushima T.... Utsunomiya H.	2007	ALPP
11	Genetic alterations of E-cadherin and beta-catenin in germinoma and teratoma: report of two central nervous system cases. (18158575)	Pecina-Slaus N.... Tomas D.	2007	CDH1
12	Primitive intracranial trigeminal nerve germinoma. Case report (17337016)	Baussart B.... Gaillard S.	2007	CGB
13	Elevated cerebrospinal fluid levels of placental alkaline phosphatase and beta-human chorionic gonadotrophin in a case of intracranial germinoma with normal levels in blood. (18040139)	Rao P.... Natu S.M.	2007	ALPP, CGB7
14	Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. (16718353)	Mishima K.... Matsutani M.	2006	PDPN
15	The role of radiotherapy in the treatment of childhood intracranial germinoma: long-term survival and late effects. (16047364)	Strojan P.... Jereb B.	2006	CGB
16	C-kit gene mutation: common and widely distributed in intracranial germinomas. (16572634)	Kamakura Y.... Fujisawa H.	2006	KIT
17	Precocious puberty caused by hCG-producing germinoma involving the bilateral basal ganglia and cerebral white matter without 1ypical radiologic findings: case report (16768139)	Sugiyama S.... Tominaga T.	2006	CGB5
18	C-kit expression in germinoma: an immunohistochemistry-based study. (16132509)	Nakamura H.... Kuratsu J.	2005	ALPP
19	CNS germinoma with elevated serum human chorionic gonadotropin level: clinical characteristics and treatment outcome. (15936563)	Ogino H.... Mimura M.	2005	CGA
20	Elevated levels of human chorionic gonadotropin-beta, a marker of active neurohypophyseal germinoma, detected by immune complex transfer enzyme immunoassay. (16010454)	Yoshizawa A.... Yamada S.	2004	CGB
21	Expression and distribution of c-kit receptor and its ligand in human CNS germ cell tumors: a useful histological marker for the diagnosis of germinoma. (15696963)	Takeshima H.... Kuratsu J.	2004	KITLG
22	c-kit gene mutations in intracranial germinomas. (15471556)	Sakuma Y.... Saito K.	2004	KIT
23	Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients. (14967424)	Ogawa K.... Murayama S.	2004	CGB5
24	Germinoma with syncytiotrophoblastic giant cells recu rring 13 years after radiotherapy for a pineal germinoma--case report. (12699124)	Fujikawa K.... Kuratsu J.	2003	CGB5
25	Germinoma with a granulomatous reaction. Problems of differential diagnosis. (12489672)	Konno S.... Yagishita S.	2002	ALPP
26	CNS germinoma in a boy with simple virilizing 21-hydroxylase deficiency and precocious puberty. (11926207)	Bajpai A.... Menon P.S.	2002	AFP, CYP21A2, CGB5
27	Pituitary germinoma presenting as a pseudotumoral lymphocytic hypophysitis in a man (11937977)	Torremocha F.... MarAcchaud R.	2002	ALPP
28	Impacts of elevated level of hCG in serum on clinical course and radiotherapy results in the histology-confirmed intracranial germinomas. (11321670)	Shin K.H.... Choe G.	2001	CGB5
29	Metastatic spinal intramedullary germinoma with elevated cerebrospinal fluid chorionic gonadotropin: a case report. (10717404)	Kuba H.... Fukui M.	2000	CGB
30	A comparative study of apoptosis and proliferation in germinoma and glioblastoma. (11303626)	Mizoguchi M.... Fukui M.	2000	BCL2, BAX
31	A rare case of extramedullary spinal cord germinoma. (10504524)	Kiyuna M.... Nakashima Y.	1999	ALPP
32	Diabetes insipidus and increased serum levels of lept in and lactate-dehydrogenase (LDH) in an adolescent boy with a primary intracra nial germinoma. Case report and an endocrinological revaluation of literature. (10475155)	Carella C.... Bellastella A.	1999	PRL
33	Cerebral germinoma with syncytiotrophoblastic giant cells: feasibility of predicting prognosis using the serum hCG level. (10526079)	Utsuki S.... Fujii K.	1999	CGA
34	Human chorionic gonadotrophin in CSF, not serum, predicts outcome in germinoma. (10209181)	Inamura T.... Fukui M.	1999	CGA
35	Suprasellar germinomas in childhood and adolescence: diagnostic pitfalls. (9829222)	Ramelli G.P.... Buergi U.	1998	PRL
36	Extraneural metastasis of intracranial germinoma with syncytiotrophoblastic giant cells--case report. (9805904)	Akai T.... Nojima T.	1998	CGB, CGB5
37	Occult neurohypophyseal germinomas in patients presen ting with central diabetes insipidus. (17140187)	Kato T.... Fujieda K.	1998	CGB
38	Expression of CD44 adhesion molecules in intracranial germinomas. (17140184)	Huang T.Y.... Ushio Y.	1998	CD44
39	Intracranial germinoma: the case for lower dose radia tion therapy. (9308946)	Hardenbergh P.H.... Tarbell N.J.	1997	CGB
40	Prognosis of intracranial germinoma with syncytiotrophoblastic giant cells treated by radiation therapy. (9112445)	Shibamoto Y.... Sasai K.	1997	CGB5
41	Germinoma of the optic nerve: case report. (8958513)	Iizuka H.... Kadoya S.	1996	ALPP
42	Aromatase expression in human germinomas with possible biological effects. (8530631)	O'Marcaigh A.S.... Zimmerman D.	1995	CYP19A1, CGA
43	Primary germinoma of the spinal cord: a case report with 28-year follow-up and review of the literature. (8615089)	Slagel D.D.... Moore S.A.	1995	ALPP
44	A phase II trial of preirradiation carboplatin in newly diagnosed germinoma of the central nervous system. (8039122)	Allen J.C.... Nirenberg A.	1994	CGB5
45	Germinoma of the medulla oblongata--case report. (7519750)	Sugiyama K.... Ikawa F.	1994	ALPP
46	Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein. (7505047)	Nashold J.R.... Tien R.	1994	AFP
47	A case of pineal region germinoma treated by interst itial brachytherapy (8078603)	Higashi H.... Ohmoto T.	1994	CGA
48	Histopathological study of intracranial germinoma (8403104)	Lai R.Q.	1993	PSG1, TRIM26
49	Cerebrospinal fluid placental alkaline phosphatase in the intracranial germinomas: results of enzyme antigen immunoassay. (1723169)	Ono N.... Tamura M.	1991	ALPP
50	A comparative morphological and immunohistochemical study of testicular seminomas and intracranial germinomas. (2076869)	Bentley A.J.... Lantos P.L.	1990	ALPP

Genes related to germinoma according to GeneCards:

(show all 27)

id	Symbol	Description	Score	GeneCards Section Context
1	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
2	ALPP	alkaline phosphatase, placental	11.0	Publications
3	POU5F1	POU class 5 homeobox 1	11.0	Publications
4	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
5	AFP	alpha-fetoprotein	11.0	Publications
6	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
7	PDPN	podoplanin	11.0	Publications
8	INHA	inhibin, alpha	11.0
9	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
10	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
11	ESRG	embryonic stem cell related (non-protein coding)	11.0	Publications
12	TSPY1	testis specific protein, Y-linked 1	11.0
13	PSG1	pregnancy specific beta-1-glycoprotein 1	11.0	Publications
14	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
15	TRIM26	tripartite motif containing 26	11.0	Publications
16	ALPI	alkaline phosphatase, intestinal	11.0
17	DHCR7	7-dehydrocholesterol reductase	11.0	Publications
18	AVP	arginine vasopressin	11.0
19	KITLG	KIT ligand	11.0	Publications
20	APC	adenomatous polyposis coli	11.0	Publications
21	DMRT1	doublesex and mab-3 related transcription factor 1	11.0
22	CD44	CD44 molecule (Indian blood group)	11.0	Publications
23	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
24	BAX	BCL2-associated X protein	11.0	Publications
25	PRL	prolactin	11.0	Publications
26	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
27	BCL2	B-cell CLL/lymphoma 2	11.0	Publications

Pathways related to germinoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Melanocyte Development and Pigmentation36	9.3	BCL2, KITLG, KIT
2	Selected targets of Oct-3/410	9.2	CGB7, POU5F1, CDH1, CGB
3	Selected targets of p5310	9.1	BAX, APC, BCL2
4	Pathways in cancer20	8.6	BCL2, CDH1, BAX
5	p53 Mediated Apoptosis36	8.6	BCL2, KIT, KITLG, BAX

Compounds related to germinoma according to GeneDecks:

(show top 50)    (show all 136)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.2	AFP, CGB, KIT, CGB5
2	ctp32	9.9	CGB, CGB5, CGB7, CGA
3	bleomycin32 9 9	11.8	CD44, AFP, CGB, CGB7
4	oestriol32	9.8	PSG1, CGB, CGB7, AFP, CGA, CGB5
5	gnrh32	9.7	CYP21A2, CGB, CGB5, CGB7, INHA, KITLG
6	3beta-hydroxysteroid32	9.6	CYP21A2, CYP19A1, INHA, CGB5, CGA
7	dehydroepiandrosterone sulfate32	9.6	CGB5, CGA, PRL, CYP21A2
8	epinephrine32 9 18 9	12.5	AFP, CYP21A2, APC, CGB5, CGA, KITLG
9	estradiol benzoate32	9.4	CYP19A1, CGB5, PRL, CGA
10	buserelin32 9 9	11.3	PRL, CGA, CGB5, CYP19A1
11	leuprolide acetate32	9.2	CYP19A1, PRL, CGB5, CGA, CYP21A2
12	17-hydroxyprogesterone32 18	10.2	CGB5, CYP19A1, CYP21A2, PRL, CGA
13	thyroxine32 18	10.1	AFP, CGA, PRL, CYP21A2, ALPP, CGB7
14	androstenedione32 18	10.1	CGA, INHA, CYP19A1, CYP21A2, PRL, CGB
15	clomiphene citrate32	9.0	CYP21A2, CGA, CGB5, CYP19A1, PRL, CGB
16	dihydrotestosterone32 9 18 9	12.0	CYP19A1, CGB5, PRL, CGA, CYP21A2
17	ribonucleic acid32	8.8	CYP21A2, CGA, KIT, INHA, PRL, KITLG
18	folate32	8.7	ALPP, APC, CDH1, CGB5, AFP, CGA
19	mifepristone32 42 9 9	11.6	PRL, CYP19A1, CGB5, CGB, CGA, BAX
20	carboplatin32 34 9 9	11.6	AFP, BCL2, KITLG, CGA, CD44
21	exisulind32	8.5	BCL2, CDH1, APC, BAX
22	vinblastine32 9 9	10.4	AFP, CGB5, CGA, BAX, BCL2, CDH1
23	norepinephrine32 9 18 9	11.4	CGA, KITLG, AVP, POU5F1, PRL, CYP21A2
24	progestin32	8.4	PRL, CYP19A1, ALPP, CDH1, CGB5, CGA
25	actinomycin d32	8.3	AFP, BAX, CGB5, CD44, CGA, BCL2
26	agarose32	8.3	ALPI, CYP21A2, KIT, CD44, KITLG, BCL2
27	methotrexate32 34 42 9 9	12.2	CYP19A1, CGB7, CGB, AFP, CDH1, KIT
28	lactate32	8.1	CDH1, CGB7, CGB5, CGA, AFP, ALPP
29	estradiol32 9 18 9	11.0	CYP21A2, CYP19A1, CGB5, CGB7, INHA, AFP
30	vitamin d32	8.0	CGA, CD44, CDH1, CYP19A1, AFP, ALPP
31	creatinine32	7.9	AFP, AVP, CD44, ALPP, CGB, CGA
32	5fluorouracil32	7.7	BAX, CYP19A1, CDH1, KITLG, KIT, BCL2
33	etoposide32 42 9 9	10.7	BCL2, CGB, CDH1, CD44, CGB7, CGB5
34	celecoxib32 42 34 9 18 9	12.7	APC, CYP19A1, CDH1, BAX, BCL2
35	pge232	7.7	CDH1, ALPP, CYP19A1, APC, CD44, CGB5
36	genistein32 9 18 9	10.5	ALPP, CYP21A2, KITLG, CYP19A1, BAX, CGB5
37	cycloheximide32	7.4	CGB5, KITLG, BCL2, BAX, CGA, CYP21A2
38	steroid32	7.4	CGB5, DHCR7, KIT, KITLG, AFP, AVP
39	paclitaxel32 34 9 9	10.3	KITLG, BCL2, BAX, CGB5, CD44, CDH1
40	cisplatin32 34 9 9	10.3	KITLG, CGB5, CGB7, CD44, CDH1, ALPP
41	butyrate32	7.2	CDH1, KITLG, BCL2, BAX, CD44, AFP
42	doxorubicin32 34 9 9	10.1	CGB5, KITLG, CGA, CD44, CDH1, KIT
43	tamoxifen32 34 9 9	10.0	BAX, PRL, CYP19A1, ALPP, CDH1, CD44
44	vegf32	7.0	CGB5, CD44, CGB, CGA, CDH1, PDPN
45	paraffin32	6.8	ALPP, KIT, KITLG, BCL2, PDPN, AFP
46	dexamethasone32 42 34 9 9	10.7	AFP, PRL, CYP19A1, ALPP, CDH1, CD44
47	retinoic acid32 42 18	8.4	CD44, CDH1, CYP19A1, APC, ALPP, CGB7
48	testosterone32 9 18 9	9.3	KIT, KITLG, CGA, CGB5, CGB7, CD44
49	progesterone32 42 9 18 9	10.0	PSG1, CYP21A2, CYP19A1, APC, INHA, CDH1
50	estrogen32	5.5	CD44, PRL, KIT, KITLG, BCL2, BAX

Biological processes related to germinoma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of melanocyte differentiation	GO:045636	9.7	KITLG, BCL2
2	lymphoid progenitor cell differentiation	GO:002320	9.7	BCL2, KIT
3	germ cell programmed cell death	GO:035234	9.6	KITLG, BAX, KIT
4	regulation of nitrogen utilization	GO:006808	9.5	BAX, BCL2
5	regulation of protein homodimerization activity	GO:043496	9.4	BCL2, BAX
6	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.2	CD44, AVP, BCL2
7	regulation of protein heterodimerization activity	GO:043497	9.1	BCL2, BAX
8	ovarian follicle development	GO:001541	8.9	KIT, INHA, BAX, BCL2, KITLG
9	cell-cell adhesion	GO:016337	8.7	PDPN, CDH1, CD44, BCL2
10	male gonad development	GO:008584	8.6	DMRT1, INHA, BCL2, KITLG, KIT, CYP19A1

Molecular functions related to germinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	alkaline phosphatase activity	GO:004035	10.1	ALPI, ALPP
2	hormone activity	GO:005179	9.3	CGA, CGB, INHA, PRL
3	BH3 domain binding	GO:051434	9.1	BCL2, BAX