MCID: GRM004
MIFTS: 43

Germinoma malady

Summaries for Germinoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 A germinoma is a type of germ cell tumor, which is not differentiated upon examination. It may be benign... more...

MalaCards: Germinoma is related to teratoma and diabetes insipidus. An important gene associated with Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and Regulation of KIT signaling. The compounds 11-ketotestosterone and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Germinoma

Sources:
43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS
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Aliases & Descriptions:

germinoma 43 10 45 61


Related Diseases for Germinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Germinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.6ALPP, KIT, POU5F1, PDPN, CGA, CGB5
2diabetes insipidus30.6AVP
3klinefelter's syndrome30.4INHA, CYP21A2, CGB, CGA
4germ cell tumors30.4KIT
5precocious puberty30.4CGA, CGB5, CYP21A2
6down syndrome30.2PSG1, CGA, CGB5, CGB7, CGB, AFP
7hyperprolactinemia30.0CGA, CGB5, CGB
8adenoma30.0CGA, CGB7, CGB, CYP21A2, INHA, KITLG
9dysgerminoma30.0CGA, CGB5, AFP, POU5F1, INHA, KITLG
10testicular cancer29.8AFP, TSPY1, ALPP
11brain germinoma10.5
12pineal region germinoma10.5
13lymphocytic hypophysitis10.3
14panhypopituitarism10.2
15childhood brain germinoma10.2
16pineal cyst10.2
17mixed germ cell tumor10.2
18childhood central nervous system germinoma10.1
19adult central nervous system germinoma10.1
20astrocytoma10.1
21androgen insensitivity syndrome10.0
22carney complex10.0
23auditory agnosia10.0
24congenital adrenal hyperplasia10.0
25n syndrome10.0
26ollier disease10.0
27agnosia10.0
2846xy sex reversal 310.0
29proteus syndrome, somatic10.0
30blindness10.0
31intracranial embryonal carcinoma10.0
32thyroiditis10.0CGA
33epithelioid trophoblastic tumor10.0INHA
34endodermal sinus tumor10.0AFP
35waardenburg's syndrome10.0ALPP
36hypertension10.0AVP
37diabetes mellitus10.0ALPP
38cushing's syndrome10.0CYP21A2
39male infertility10.0TSPY1
40adrenal rest tumor10.0CYP21A2
41teratocarcinoma10.0POU5F1
42kidney cancer10.0PDPN
43insulin resistance10.0CYP21A2
44gestational trophoblastic neoplasm10.0PSG1
45rhabdomyosarcoma10.0INHA
46sertoli cell tumor10.0ALPP, INHA
47cholestasis10.0ALPP
48gonadal dysgenesis10.0DMRT1
49osteosarcoma10.0CGB, ALPP
50angiomyolipoma10.0KIT

Graphical network of the top 20 diseases related to Germinoma:



Diseases related to germinoma

Clinical Features for Germinoma

Drugs & Therapeutics for Germinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Germinoma

Drug clinical trials:

Search ClinicalTrials for Germinoma

Search NIH Clinical Center for Germinoma

Search CenterWatch for Germinoma

Genetic Tests for Germinoma

Anatomical Context for Germinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Germinoma:

33
Bone marrow, Whole blood, Brain, Spinal cord, Heart, Adrenal gland, Testis, Temporal lobe, Thalamus, Medulla oblongata, Trigeminal ganglion, Pineal, Pituitary, Testis germ

Animal Models for Germinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Germinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.2DMRT1, CGA, AFP, POU5F1, INHA, KITLG
2MP:00053898.7DMRT1, CGA, AFP, POU5F1, INHA, KITLG

Publications for Germinoma

Sources:
51PubMed
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Articles related to Germinoma:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Intracranial germinoma in the pineal region arising after subtotal resection of epidermoid cyst: case report. (24221216)
2013
2
An unusual anatomic and geographic location of primary germinoma of the fourth ventricle. (23896551)
2013
3
Primary human chorionic gonadotropin secreting germinoma of the corpus callosum. (24233184)
2013
4
SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease. (23460321)
2013
5
Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the ventricular trigone. (22347677)
2012
6
Intracranial germinoma manifesting as cavernous sinus syndrome--case report. (23095271)
2012
7
Salvage treatment for recurrent intracranial germinoma after reduced-volume radiotherapy: a single-institution experience and review of the literature. (22361082)
2012
8
Multifocal intracranial germinoma with raised tumour markers in serum but not in CSF and with carcinoma in situ of the testis. (21859353)
2012
9
Spontaneous regression of germinoma in the pineal region before endoscopic surgery: a pitfall of modern strategy for pineal germ cell tumors. (20949306)
2011
10
A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma. (21046314)
2010
11
Germinoma with malignant transformation to nongerminomatous germ cell tumor. (20809716)
2010
12
Pineal germinoma. (20818311)
2010
13
Germinoma of basal ganglia in female: case report and review of the literature. (19082612)
2009
14
Use of 11C-methionine positron emission tomography in basal germinoma: assessment of treatment response and residual tumor. (19296116)
2009
15
Diffusion-weighted imaging characteristics of primary central nervous system germinoma with histopathologic correlation: a retrospective study. (19643635)
2009
16
Isolated lymphocytic infiltration of pituitary stalk preceding the diagnosis of germinoma in 2 prepubertal children treated with growth hormone. (19571561)
2009
17
Intracranial germinoma as a very rare cause of panhypopituitarism in a 23-year old man. (19053025)
2009
18
Basal ganglia germinoma: diagnostic value of MR spectroscopy and (11)C-methionine positron emission tomography. (18371980)
2008
19
Inherent diagnostic and treatment challenges in germinoma of the basal ganglia: a case report and review of the literature. (18365143)
2008
20
Two patients with intraspinal germinoma associated with Klinefelter syndrome: case report and review of the literature. (16775265)
2006
21
Low-dose prophylactic craniospinal radiotherapy for intracranial germinoma. (16530341)
2006
22
Recurrent intracranial germinoma outside the initial radiation field: a single-institution study. (16760185)
2006
23
Pineal germinoma presenting as anorexia nervosa: Case report and review of the literature. (17041920)
2006
24
Limited-field radiation for bifocal germinoma. (16530340)
2006
25
Life-threatening airway obstruction caused by mediastinal germinoma in a 9-year-old girl. (15793744)
2005
26
Stereotactic radiosurgery followed by whole ventricular irradiation for primary intracranial germinoma of the pineal region. (16015498)
2005
27
Two cases of pineal germinoma with granulomatous inflammation. (15851091)
2005
28
Report of two cases with germinoma treated by individual adjuvant chemotherapy based on the mRNA expression of drug-resistance gene]. (14978920)
2004
29
A case of sudden death from primary intracranial germinoma complicated by microvascular disease of the heart. (14550605)
2003
30
De novo germinoma in the brain in association with Klinefelter's syndrome: case report and review of the literature. (14670679)
2003
31
Late recurrence of pineal germinoma. (11834272)
2002
32
Does hypopituitarism due to neurohypophyseal germinoma recover after chemotherapy? (12054110)
1999
33
Germinoma causing wallerian degeneration. Case report and review of the literature. (9420084)
1998
34
Long-term follow-up of germinoma after stereotactic biopsy and brain radiotherapy: a cell kinetics study. (9758297)
1998
35
Relapse of intracranial germinoma 23 years postirradiation in a patient given growth hormone replacement. (9142205)
1997
36
Intracranial germinoma with Down's syndrome: a case report and review of the literature. (8986161)
1997
37
Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein. (7505047)
1994
38
Combination chemotherapy with cisplatin and etoposide for hematogenous spinal metastasis of intracranial germinoma--case report. (7680780)
1993
39
Metastasis of pineal germinoma via ventriculoperitoneal shunt. (8481144)
1993
40
Intracranial germinoma and Down's syndrome--case report. (1377800)
1992
41
Intracranial and spinal germinomas occurring four years after spinal cord germinoma--case report. (1723162)
1991
42
Germinoma in a 16-month old baby: a case report with brief review of the literature. (1927614)
1991
43
Angiotensin I-converting enzyme in a suprasellar germinoma. (3028124)
1987
44
Metastasizing pineal germinoma. A case report and review. (2409609)
1985
45
Surgical resection of a pineal tumor containing elements of germinoma and astrocytoma. (3982617)
1985
46
Intracranial germinoma in a dog. (6730227)
1984
47
Microsurgery of teratoma and germinoma involving the diencephalon and the brain stem. (6657078)
1983
48
Metastasis of intracranial germinoma through a ventriculoperitoneal shunt. (7272927)
1981
49
Diagnosis and treatment of suprasellar germinoma. (290221)
1979
50
Neuroradiological aspects of suprasella germinoma. (313023)
1979

Genetic Variations for Germinoma

Expression for genes affiliated with Germinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germinoma

Search GEO for disease gene expression data for Germinoma.

Pathways for genes affiliated with Germinoma

Sources:
54Reactome, 30KEGG, 12EMD Millipore
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Pathways related to Germinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CGB, CGA
210.1KIT, KITLG
39.9ALPI, ALPP
49.9POU5F1, CGB, CGB7

Compounds for genes affiliated with Germinoma

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
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Compounds related to Germinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone4510.4CGB5, CGA
2cycloheximide4510.3ALPP, CGB5
317-hydroxypregnenolone4510.3CYP21A2, CGB5, CGA
4leuprolide acetate4510.3CGA, CGB5, CYP21A2
517-hydroxyprogesterone45 2411.2CGA, CGB5, CYP21A2
6ifosfamide45 1111.2CGA, CGB, AFP, CGB5
73beta-hydroxysteroid4510.2CGA, CGB5, CYP21A2, INHA
8b 7234510.1PDPN, AFP, ALPP
9mifepristone45 60 29 1113.1CGB, CGA, AFP, CGB5
10ctp4510.1CGB5, CGB7, CGB, CGA
11vincristine45 50 1112.1CGB5, CGB, AFP, KIT
12clomiphene citrate4510.1CGB5, AFP, CYP21A2, CGA, CGB
13androstenedione45 2411.0CGB5, CGA, CGB, INHA, CYP21A2
14hydroxyurea45 50 1112.0CGB5, KITLG, ALPP, KIT
15cyclophosphamide45 50 1112.0CGA, KITLG, CGB5, CGB, AFP
16carbon459.9AFP, CGA, AVP, CYP21A2
17gold459.9PDPN, AFP, KITLG, KIT
18dehydroepiandrosterone sulfate459.9CYP21A2, CGA, CGB5
19epinephrine45 11 2411.9CGA, CGB5, AFP, KITLG, CYP21A2
20bleomycin45 1110.9CGB, AFP, CGB5, CGA, CGB7
21simvastatin45 50 60 29 11 2414.9KITLG, ALPP, DHCR7, AFP
22dmso459.9AFP, KITLG, ALPP, CGA, CGB5
23etoposide45 50 60 1112.8AFP, CGA, CGB7, CGB5, CGB
24agarose459.8KITLG, KIT, CYP21A2, INHA, ALPI
25diethylstilbestrol45 29 1111.8AFP, CGB5, CGA
26glucose459.8CGB5, CYP21A2, CGB, AVP, KITLG
27ribonucleic acid459.8CYP21A2, INHA, KIT, CGA, CGB5, KITLG
28folate459.8AFP, CGB5, CGA, ALPP
29thyroxine45 2410.8AFP, ALPP, CYP21A2, CGB7, CGB, CGA
30doxorubicin45 50 1111.8KIT, KITLG, AFP, CGA, CGB5
31actinomycin d459.7CGA, CGB5, AFP, KITLG, KIT
32ethanol45 50 11 2412.7KITLG, ALPI, AFP, CGB5, AVP
3317beta-hydroxysteroid459.6CGB5, CGA, CYP21A2
34oestriol459.6CGB5, AFP, CGB, CGB7, CGA, PSG1
35creatinine459.6AVP, CGB5, ALPP, CGA, KITLG, AFP
36norepinephrine45 11 2411.6ALPP, CYP21A2, POU5F1, CGA, CGB5, AVP
37gnrh459.6CGB7, CGB5, CGB, CYP21A2, CGA, KITLG
38alanine459.6AFP, KITLG, ALPP, CGA, AVP, INHA
39methotrexate45 50 1111.5KITLG, KIT, CGA, CGB7, CGB, AFP
40cisplatin45 50 60 1112.5AFP, CGB7, CGB5, CGA, CGB, ALPP
41dexamethasone45 50 29 1112.4KITLG, CGB5, CYP21A2, ALPP, AFP, AVP
42paraffin459.3CGA, PDPN, CGB5, AFP, KITLG, KIT
43lactate459.3AFP, ALPP, CGB, CGB7, CGB5, CGA
44retinoic acid45 2410.3ALPP, KIT, KITLG, POU5F1, AFP, CGB7
45steroid459.3AVP, KITLG, AFP, DHCR7, INHA, CGB5
46vegf459.2POU5F1, CGB, CGB5, KITLG, KIT, CGA
47progesterone45 60 29 11 2413.1KIT, INHA, CGB, CYP21A2, CGB7, CGB5
48estradiol45 11 2411.1CGA, CGB7, CGB, AFP, CYP21A2, INHA
49testosterone45 60 11 2412.0CGA, CGB7, CGB5, CGB, AFP, CYP21A2
50serine459.0AVP, CYP21A2, CGA, CGB5, AFP, KITLG

GO Terms for genes affiliated with Germinoma

Sources:
16Gene Ontology
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Biological processes related to Germinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.2CGB, CGA
2germ cell programmed cell deathGO:03523410.1KIT, KITLG
3male gonad developmentGO:0085849.8KIT, DMRT1, INHA, KITLG
4cell-cell signalingGO:0072679.7CGA, CGB, INHA, AVP
5regulation of cell proliferationGO:0421279.6DHCR7, KIT, INHA
6signal transductionGO:0071659.3KIT, PDPN, CGA, KITLG, AVP, INHA

Molecular functions related to Germinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.0INHA, CGB, CGA
2alkaline phosphatase activityGO:0040359.6ALPI, ALPP

Products for genes affiliated with Germinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Germinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet