MCID: GRM004
MIFTS: 30

Germinoma malady

Summaries for Germinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A germinoma is a type of germ cell tumor, which is not differentiated upon examination. It may be benign... more...

MalaCards: Germinoma is related to diabetes insipidus and seminoma. An important gene associated with Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and Regulation of KIT signaling. The compounds 11-ketotestosterone and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Germinoma

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42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

germinoma 42 10 44 60


Related Diseases for Germinoma

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17GeneCards, 18GeneDecks
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Diseases related to Germinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus30.5AVP
2seminoma30.4ALPP, ALPI, KIT, KITLG, INHA, PDPN
3klinefelter's syndrome30.3INHA, CYP21A2, CGB, CGA
4hypopituitarism30.2CGA, CYP21A2, AVP
5hyperprolactinemia30.0CGA, CGB5, CGB
6choriocarcinoma29.9PSG1, CGA, CGB5, CGB7, CGB, AFP
7gonadal dysgenesis29.7DMRT1
821-hydroxylase deficiency29.7CYP21A2, INHA
9testicular cancer29.7AFP, TSPY1, ALPP
10pituitary adenoma29.7CGA, CGB7, POU5F1, INHA
11sarcoma29.7KIT, KITLG, CGB, CGB5
12adenoma29.7CGA, CGB7, CGB, CYP21A2, INHA, KITLG
13down syndrome29.7PSG1, CGA, CGB5, CGB7, CGB, AFP
14central nervous system germinoma10.6
15brain germinoma10.5
16pineal region germinoma10.4
17cerebritis10.4
18mediastinitis10.3
19cervicitis10.2
20mature teratoma10.2
21panhypopituitarism10.1
22childhood brain germinoma10.1
23peritonitis10.1
24childhood central nervous system germinoma10.1
25adult central nervous system germinoma10.1
26astrocytoma10.1
27meningioma10.1
28androgen insensitivity syndrome10.0
29carney complex10.0
30auditory agnosia10.0
31congenital adrenal hyperplasia10.0
32neuronitis10.0
33cornelia de lange syndrome10.0
34ollier disease10.0
35agnosia10.0
36hydrocephalus10.0
37medulloblastoma10.0
38meningitis10.0
39retinitis10.0
4046xy sex reversal 310.0
41proteus syndrome, somatic10.0
42thyroiditis10.0CGA
43germ cell tumors10.0KIT
44epithelioid trophoblastic tumor10.0INHA
45endodermal sinus tumor10.0AFP
46waardenburg's syndrome10.0ALPP
47hypertension10.0AVP
48diabetes mellitus10.0ALPP
49cushing's syndrome10.0CYP21A2
50male infertility10.0TSPY1

Graphical network of the top 20 diseases related to Germinoma:



Diseases related to germinoma

Clinical Features for Germinoma

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Drugs & Therapeutics for Germinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Germinoma

Drug clinical trials:

Search ClinicalTrials for Germinoma

Search NIH Clinical Center for Germinoma

Search CenterWatch for Germinoma

Genetic Tests for Germinoma

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Anatomical Context for Germinoma

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Animal Models for Germinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Germinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.2CGA, AFP, POU5F1, INHA, KITLG, KIT
2MP:00053898.7ALPP, DMRT1, CGA, AFP, POU5F1, INHA

Publications for Germinoma

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Genetic Variations for Germinoma

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Expression for genes affiliated with Germinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germinoma

Search GEO for disease gene expression data for Germinoma.

Pathways for genes affiliated with Germinoma

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53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Germinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CGB, CGA
210.1KIT, KITLG
39.9ALPI, ALPP
49.9POU5F1, CGB, CGB7

Compounds for genes affiliated with Germinoma

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Germinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone4410.4CGB5, CGA
2cycloheximide4410.3ALPP, CGB5
317-hydroxypregnenolone4410.3CYP21A2, CGB5, CGA
4leuprolide acetate4410.3CGA, CGB5, CYP21A2
517-hydroxyprogesterone44 2411.2CGA, CGB5, CYP21A2
6ifosfamide44 1111.2CGA, CGB, AFP, CGB5
73beta-hydroxysteroid4410.2CGA, CGB5, CYP21A2, INHA
8b 7234410.1PDPN, AFP, ALPP
9mifepristone44 59 28 1113.1CGB, CGA, AFP, CGB5
10ctp4410.1CGB5, CGB7, CGB, CGA
11vincristine44 49 1112.1CGB5, CGB, AFP, KIT
12clomiphene citrate4410.1CGB5, AFP, CYP21A2, CGA, CGB
13androstenedione44 2411.0CGB5, CGA, CGB, INHA, CYP21A2
14hydroxyurea44 49 1112.0CGB5, KITLG, ALPP, KIT
15cyclophosphamide44 49 1112.0CGA, KITLG, CGB5, CGB, AFP
16carbon449.9AFP, CGA, AVP, CYP21A2
17gold449.9PDPN, AFP, KITLG, KIT
18dehydroepiandrosterone sulfate449.9CYP21A2, CGA, CGB5
19epinephrine44 11 2411.9CGA, CGB5, AFP, KITLG, CYP21A2
20bleomycin44 1110.9CGB, AFP, CGB5, CGA, CGB7
21simvastatin44 49 59 28 11 2414.9KITLG, ALPP, DHCR7, AFP
22dmso449.9AFP, KITLG, ALPP, CGA, CGB5
23etoposide44 49 59 1112.8AFP, CGA, CGB7, CGB5, CGB
24agarose449.8KITLG, KIT, CYP21A2, INHA, ALPI
25diethylstilbestrol44 28 1111.8AFP, CGB5, CGA
26glucose449.8CGB5, CYP21A2, CGB, AVP, KITLG
27ribonucleic acid449.8CYP21A2, INHA, KIT, CGA, CGB5, KITLG
28folate449.8AFP, CGB5, CGA, ALPP
29thyroxine44 2410.8AFP, ALPP, CYP21A2, CGB7, CGB, CGA
30doxorubicin44 49 1111.8KIT, KITLG, AFP, CGA, CGB5
31actinomycin d449.7CGA, CGB5, AFP, KITLG, KIT
32ethanol44 49 11 2412.7KITLG, ALPI, AFP, CGB5, AVP
3317beta-hydroxysteroid449.6CGB5, CGA, CYP21A2
34oestriol449.6CGB5, AFP, CGB, CGB7, CGA, PSG1
35creatinine449.6AVP, CGB5, ALPP, CGA, KITLG, AFP
36norepinephrine44 11 2411.6ALPP, CYP21A2, POU5F1, CGA, CGB5, AVP
37gnrh449.6CGB7, CGB5, CGB, CYP21A2, CGA, KITLG
38alanine449.6AFP, KITLG, ALPP, CGA, AVP, INHA
39methotrexate44 49 1111.5KITLG, KIT, CGA, CGB7, CGB, AFP
40cisplatin44 49 59 1112.5AFP, CGB7, CGB5, CGA, CGB, ALPP
41dexamethasone44 49 28 1112.4KITLG, CGB5, CYP21A2, ALPP, AFP, AVP
42paraffin449.3CGA, PDPN, CGB5, AFP, KITLG, KIT
43lactate449.3AFP, ALPP, CGB, CGB7, CGB5, CGA
44retinoic acid44 2410.3ALPP, KIT, KITLG, POU5F1, AFP, CGB7
45steroid449.3AVP, KITLG, AFP, DHCR7, INHA, CGB5
46vegf449.2POU5F1, CGB, CGB5, KITLG, KIT, CGA
47progesterone44 59 28 11 2413.1KIT, INHA, CGB, CYP21A2, CGB7, CGB5
48estradiol44 11 2411.1CGA, CGB7, CGB, AFP, CYP21A2, INHA
49testosterone44 59 11 2412.0CGA, CGB7, CGB5, CGB, AFP, CYP21A2
50serine449.0AVP, CYP21A2, CGA, CGB5, AFP, KITLG

GO Terms for genes affiliated with Germinoma

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16Gene Ontology
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Biological processes related to Germinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:01648610.2CGB, CGA
2germ cell programmed cell deathGO:03523410.1KITLG, KIT
3male gonad developmentGO:0085849.8KIT, KITLG, INHA, DMRT1
4cell-cell signalingGO:0072679.7AVP, INHA, CGB, CGA
5regulation of cell proliferationGO:0421279.6INHA, DHCR7, KIT
6signal transductionGO:0071659.3PDPN, CGA, CGB, INHA, AVP, KITLG

Molecular functions related to Germinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.0INHA, CGB, CGA
2alkaline phosphatase activityGO:0040359.6ALPI, ALPP

Products for genes affiliated with Germinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Germinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet