MCID: GRM004
MIFTS: 39

Germinoma malady

Rare diseases category

Summaries for Germinoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A germinoma is a type of germ cell tumor, which is not differentiated upon examination. It may be benign... more...

MalaCards: Germinoma is related to teratoma and precocious puberty. An important gene associated with Germinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Metabolism of steroid hormones and vitamin D and Selected targets of Oct 3 4. The compounds oestriol and ctp have been mentioned in the context of this disorder. Affiliated tissues include pineal, spinal cord and brain.

Aliases & Classifications for Germinoma

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44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

germinoma 44 11 46 63


Related Diseases for Germinoma

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18GeneCards, 19GeneDecks
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Diseases related to Germinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.6POU5F1, CGB, CGA
2precocious puberty30.5CGA, CYP21A2
3seminoma30.4INHA, POU5F1, CGB, CGA
4hypopituitarism30.3CGA, CYP21A2
5klinefelter's syndrome30.2CYP21A2, INHA, CGB, CGA
6hyperprolactinemia30.1CGB, CGA
7choriocarcinoma30.0INHA, CGB, CGA
8dysgerminoma30.0CGA, POU5F1, INHA
9prolactinoma29.8CGA, CGB
1021-hydroxylase deficiency29.8CYP21A2, INHA
11testicular cancer29.8CGA, CGB, INHA
12down syndrome29.8CGA, CGB, INHA
13pituitary adenoma29.7CGA, POU5F1, INHA
14adenoma29.7CYP21A2, INHA, CGB, CGA
15central nervous system germinoma10.5
16cerebritis10.4
17diabetes insipidus10.4
18germ cell tumors10.4
19mediastinitis10.4
20brain germinoma10.3
21lymphocytic hypophysitis10.3
22pineal region germinoma10.2
23cervicitis10.2
24panhypopituitarism10.2
25childhood brain germinoma10.2
26peritonitis10.2
27mixed germ cell tumor10.2
28childhood central nervous system germinoma10.1
29adult central nervous system germinoma10.1
30astrocytoma10.1
31mature teratoma10.1
32meningioma10.1
33adrenal rest tumor10.1CYP21A2
34pineoblastoma10.1POU5F1
35epithelioid trophoblastic tumor10.1INHA
36gestational trophoblastic tumor10.0CGB, CGA
37ectopic pregnancy10.0CGB, CGA
38luteoma10.0CYP21A2, CGA
39pregnancy loss10.0CGA, CGB
40anovulation10.0CGA, CYP21A2
41neural tube defects10.0CGA, CGB
42polycystic ovary syndrome10.0CYP21A2, CGA
43hypospadias10.0CYP21A2, CGA
44male infertility10.0CYP21A2, CGA
45hyperandrogenism10.0CGA, CYP21A2
46congenital adrenal hyperplasia10.0
47auditory agnosia10.0
48neuronitis10.0
49cornelia de lange syndrome10.0
50ollier disease10.0

Graphical network of the top 20 diseases related to Germinoma:



Diseases related to germinoma

Symptoms for Germinoma

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Drugs & Therapeutics for Germinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Germinoma

Drug clinical trials:

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Search NIH Clinical Center for Germinoma

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Genetic Tests for Germinoma

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Anatomical Context for Germinoma

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34MalaCards
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MalaCards organs/tissues related to Germinoma:

34
Pineal, Spinal cord, Brain, Pituitary, Medulla oblongata, Bone, Thalamus, Temporal lobe, Testes, Testis, Heart, Bone marrow

Animal Models for Germinoma or affiliated genes

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Publications for Germinoma

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53PubMed
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Articles related to Germinoma:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Primary intramedullary spinal cord germinoma. (23432481)
2013
2
Effective radiotherapy cured cauda equina syndrome caused by remitted intracranial germinoma depositing. (23084725)
2012
3
Precocious puberty due to human chorionic gonadotropin secreting germinoma. (23560009)
2012
4
Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the ventricular trigone. (22347677)
2012
5
A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma. (21046314)
2010
6
Germinoma of basal ganglia in female: case report and review of the literature. (19082612)
2009
7
Brain germinoma in a young adult man with suspicion of fatal neglect. (19465813)
2009
8
Use of 11C-methionine positron emission tomography in basal germinoma: assessment of treatment response and residual tumor. (19296116)
2009
9
Bilateral germinoma of the basal ganglia. (16700048)
2008
10
C-kit gene mutation: common and widely distributed in intracranial germinomas. (16572634)
2006
11
Primary germinoma of the orbit. (17152667)
2005
12
Breaking down barriers to treat a patient with a germinoma: a case study. (15366544)
2004
13
High uptake on 11C-methionine positron emission tomographic scan of basal ganglia germinoma with cerebral hemiatrophy. (14561627)
2003
14
Primary intramedullary spinal cord germinoma: case report. (12814257)
2003
15
Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central nervous system germinoma. (14595717)
2003
16
Pineal germinoma followed by hematogenous metastases. (12602751)
2003
17
CNS germinoma in a boy with simple virilizing 21-hydroxylase deficiency and precocious puberty. (11926207)
2002
18
Bilateral metachronous germinoma of the basal ganglia occurring long after total removal of a mature pineal teratoma: case report. (11841731)
2002
19
Usefulness of gallium-67 scintigraphy in neurohypophyseal germinoma. (10949440)
2000
20
Metastatic spinal intramedullary germinoma with elevated cerebrospinal fluid chorionic gonadotropin: a case report. (10717404)
2000
21
The role of chemotherapy in intracranial germinoma: a case report. (10442196)
1999
22
Metachronous neurohypophyseal germinoma occurring 8 years after total resection of pineal mature teratoma. (9457272)
1998
23
Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. (9420074)
1998
24
Radiation therapy for histologically confirmed primary central nervous system germinoma. (9276355)
1997
25
Simultaneous presentation of pineal germinoma and testicular seminoma. (8977797)
1996
26
Intramedullary spinal cord germinoma: case report and review of the literature. (8747968)
1996
27
Germinoma and choroid plexus papilloma coexisting in the fourth ventricle. (8955448)
1996
28
Aromatase expression in human germinomas with possible biological effects. (8530631)
1995
29
Complete disappearance of giant intracranial germinoma after irradiation. (8927248)
1995
30
Germinoma arising in the basal ganglia in early stage: CT and MR findings. (8850373)
1995
31
Intramedullary spinal cord germinoma. (8553123)
1995
32
A phase II trial of preirradiation carboplatin in newly diagnosed germinoma of the central nervous system. (8039122)
1994
33
Basal ganglia germinoma with crossed cerebellar diaschisis--case report. (7506817)
1993
34
The short-term effect of low-dose radiation on intracranial germinoma. A pathologic study. (1562979)
1992
35
Recurrent intracranial germinoma refractory to conventional irradiation: effective chemotherapy consisting of cisplatin and etoposide--case report. (1381062)
1992
36
Intracranial germinoma: report of seven cases. (2206859)
1990
37
Germinoma of the pineal region. (2277013)
1990
38
Germinoma originating in the basal ganglia. Report of a case showing unusual appearance on MRI. (2287389)
1990
39
Hypothalamic and basal forebrain germinoma presenting with amnesia and hyperphagia. (2922668)
1989
40
Spontaneously ruptured pineal epidermoid cyst associated with a thalamic germinoma. (2747874)
1989
41
Granulomatous inflammation in pineal germinoma. A cause of diagnostic failure at stereotaxic brain biopsy. (3046394)
1988
42
Endocrine function and growth in children with CNS tumors--with special emphasis on germinoma. (3146879)
1988
43
Germinoma in the cerebellopontine angle. (3876410)
1985
44
Systemic metastases in primary intracranial germinoma. Case report and literature review. (3995478)
1985
45
Germinoma with syncytiotrophoblastic giant cells. (6531316)
1984
46
Microsurgery of teratoma and germinoma involving the diencephalon and the brain stem. (6657078)
1983
47
Suprasellar germinoma. Unresolved problems in diagnosis, pathogenesis, and management. (6624780)
1983
48
Suprasellar germinoma in association with Klinefelter's syndrome. Case report. (6847901)
1983
49
Diagnosis and treatment of suprasellar germinoma. (290221)
1979
50
Presence of lymphocyte membrane surface markers on "small cells" in a pineal germinoma. (315205)
1979

Variations for Germinoma

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Expression for genes affiliated with Germinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Germinoma

Search GEO for disease gene expression data for Germinoma.

Pathways for genes affiliated with Germinoma

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 13EMD Millipore, 31KEGG
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Pathways related to Germinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CGA, CYP21A2
29.4POU5F1, CGB
3
Show member pathways
8.7CGA, CGB, INHA
4
Show member pathways
8.7CGA, CGB, INHA

Compounds for genes affiliated with Germinoma

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB
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Compounds related to Germinoma according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1oestriol469.9CGA, CGB
2ctp469.8CGB, CGA
3nafarelin46 62 30 1212.8CGA, CYP21A2
4ifosfamide46 1210.8CGA, CGB
517-hydroxypregnenolone469.8CYP21A2, CGA
611 deoxycortisol469.8CGA, CYP21A2
7leuprolide acetate469.8CGA, CYP21A2
817-hydroxyprogesterone46 2510.8CGA, CYP21A2
9bleomycin46 1210.7CGB, CGA
10dehydroepiandrosterone sulfate469.7CYP21A2, CGA
1117beta-hydroxysteroid469.7CYP21A2, CGA
12phenytoin46 52 30 1212.7CGA, CYP21A2
13mifepristone46 30 62 1212.7CGA, CGB
14dihydrotestosterone46 30 25 1212.5CYP21A2, CGA
15cloprostenol46 3010.5CGA, INHA
16methotrexate52 46 1211.5CGA, CGB
17carbon469.4CGA, CYP21A2
18cyclophosphamide46 52 1211.4CGB, CGA
19clomiphene citrate469.4CYP21A2, CGB, CGA
20thyroxine46 2510.4CYP21A2, CGB, CGA
21biotin46 25 1211.3INHA, CYP21A2
22agarose469.2INHA, CYP21A2
23norepinephrine46 25 1211.1CGA, POU5F1, CYP21A2
24vegf469.1CGA, CGB, POU5F1
253beta-hydroxysteroid469.0CYP21A2, INHA, CGA
26ribonucleic acid469.0CGA, INHA, CYP21A2
27cyclic amp46 259.9INHA, CGB, CGA
28forskolin46 52 1210.9CYP21A2, INHA, CGA
29steroid468.9CGA, INHA, CYP21A2
30alanine468.9INHA, CGB, CGA
31acth468.8INHA, CYP21A2
32androstenedione46 259.6CGA, CGB, INHA, CYP21A2
33gnrh468.6CGA, CGB, INHA, CYP21A2
34estradiol46 25 1210.6CGA, CGB, INHA, CYP21A2
35progesterone46 30 62 25 1212.6CYP21A2, INHA, CGB, CGA
36testosterone46 62 25 1211.5CYP21A2, INHA, CGB, CGA
37estrogen468.5CYP21A2, INHA, CGB, CGA

GO Terms for genes affiliated with Germinoma

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17Gene Ontology
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Biological processes related to Germinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.4CGA, CGB
2signal transductionGO:0071658.7CGA, CGB, INHA
3cell-cell signalingGO:0072678.4CGA, CGB, INHA

Molecular functions related to Germinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.7CGA, CGB, INHA

Products for genes affiliated with Germinoma

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Sources for Germinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet