MCID: GST052
MIFTS: 40

Gestational Choriocarcinoma malady

Reproductive diseases, Cancer diseases, Rare diseases categories

Summaries for Gestational Choriocarcinoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event... more...

MalaCards: Gestational Choriocarcinoma, also known as molar pregnancy with choriocarcinoma, is related to choriocarcinoma and ectopic pregnancy. An important gene associated with Gestational Choriocarcinoma is IFNG (interferon, gamma), and among its related pathways is Peptide hormone metabolism. The compounds indoleamine and oestriol have been mentioned in the context of this disorder. Affiliated tissues include ovary, placenta and liver.

Aliases & Classifications for Gestational Choriocarcinoma

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9Disease Ontology, 11DISEASES, 50Orphanet, 63UMLS, 41NCIt, 59SNOMED-CT, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

50
gestational choriocarcinoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

gestational choriocarcinoma 9 11 50 63
molar pregnancy with choriocarcinoma 9
gestational chorionepithelioma 9


External Ids:

Disease Ontology9 DOID:2025
NCIt41 C4646
SNOMED-CT via Orphanet60 417570003, 417057000
UMLS via Orphanet64 C0349557
ICD10 via Orphanet27 C58

Related Diseases for Gestational Choriocarcinoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Gestational Choriocarcinoma:



Diseases related to gestational choriocarcinoma

Symptoms for Gestational Choriocarcinoma

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Drugs & Therapeutics for Gestational Choriocarcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Gestational Choriocarcinoma

Search CenterWatch for Gestational Choriocarcinoma

Genetic Tests for Gestational Choriocarcinoma

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Anatomical Context for Gestational Choriocarcinoma

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34MalaCards
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MalaCards organs/tissues related to Gestational Choriocarcinoma:

34
Ovary, Placenta, Liver, Cervix, Brain, Uterus, Small intestine, Lung

Animal Models for Gestational Choriocarcinoma or affiliated genes

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Publications for Gestational Choriocarcinoma

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53PubMed
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Articles related to Gestational Choriocarcinoma:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Glycan profiling of gestational choriocarcinoma using a lectin microarray. (24424471)
2014
2
Coexistent gestational choriocarcinoma and mixed adenocarcinoma of the uterus. (24020150)
2013
3
Gestational choriocarcinoma in the fallopian tube. (24219747)
2013
4
Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma. (24163669)
2013
5
An unusual cause of lower GI bleeding in a young woman: metastatic gestational choriocarcinoma. (22421497)
2013
6
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. (24371601)
2011
7
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. (22053686)
2011
8
Gestational choriocarcinoma of Fallopian tube diagnosed with a combination of p57KIP2 immunostaining and short tandem repeat analysis: case report. (21599798)
2011
9
Gestational choriocarcinoma in one placenta of dichorionic diamniotic twins who showed severe anemia. (19608272)
2009
10
Acute abdomen as initial presentation of gestational choriocarcinoma. (19288267)
2009
11
Gestational choriocarcinoma: morphological features in a liquid-based endometrial cytological sample. (18181184)
2008
12
Gestational choriocarcinoma arising from a cornual ectopic pregnancy: a case report and review of the literature. (17581760)
2007
13
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. (16984618)
2006
14
An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. (14723763)
2004
15
Gestational choriocarcinoma: an unusual presentation with response to gemcitabine and surgery. (15008778)
2004
16
Activity of docetaxel in chemoresistant gestational choriocarcinoma. (11104635)
2000
17
A case of metastatic ovarian non-gestational choriocarcinoma: successful treatment with conservative type surgery and myeloablative chemotherapy. (10986872)
2000
18
Gestational choriocarcinoma whose responsible pregnancy was a complete hydatidiform mole identified by PCR analysis with new sequence tagged site primers. (10645807)
1999
19
Gestational choriocarcinoma. (9443570)
1997
20
Postpartal gestational choriocarcinoma fatally misdiagnosed as squamous cell cancer of the uterine cervix. (9443576)
1997
21
Gestational choriocarcinoma metastatic to the brain treated successfully by stereotactic radiosurgery and chemotherapy. (8871007)
1996
22
An extra gonadal non-gestational choriocarcinoma in a woman treated for an endometrial carcinoma. (7543866)
1995
23
Thoracotomy in the management of gestational choriocarcinoma. A clinicopathologic study. (8374875)
1993
24
Gestational choriocarcinoma in norway, 1953-92 - an epidemiologic report. (21573475)
1993
25
Another case of metastatic gestational choriocarcinoma arising from a primary fallopian tube ectopic pregnancy. (8382441)
1993
26
Documentation of complete resolution of gestational choriocarcinoma in the oophorectomized patient. (8276305)
1993
27
Gestational choriocarcinoma in a tubal ectopic pregnancy. (1315103)
1992
28
Urinary excretion of degradation products of prostacyclin and thromboxane is increased in patients with gestational choriocarcinoma. (1868436)
1991
29
Metastatic gestational choriocarcinoma. Unusual pathologic variant following therapy. (2465817)
1989
30
Establishment and characterization of three new human gestational choriocarcinoma cell lines. (3171272)
1988
31
Gestational choriocarcinoma presenting as endobronchial carcinoma. (3194870)
1988
32
Expression of HLA-DR molecules in human gestational choriocarcinoma cell lines and malignant cell lines. (3658923)
1987
33
Radioimmunoscintigraphic detection of occult gestational choriocarcinoma. (2432784)
1987
34
An immunohistological study of HLA antigen expression by gestational choriocarcinoma. (2408648)
1985
35
Neoplastic cerebral aneurysm from metastatic gestational choriocarcinoma. Case report. (4040960)
1985
36
Clinical analysis of intracranial metastases in gestational choriocarcinoma: a series of 15 cases. (3862401)
1985
37
Resistant gestational choriocarcinoma: successful treatment with vinblastine, bleomycin, and cisplatin (VBP). (6189602)
1983
38
The role of VP16-213 (etoposide; NSC-141540) in gestational choriocarcinoma. (7083462)
1982
39
Fatal gestational choriocarcinoma. Clinicopathologic study of patients treated at a trophoblastic disease center. (7116308)
1982
40
Gestational choriocarcinoma. Its origin in the placenta during seemingly normal pregnancy. (7235120)
1981
41
The role of thoracotomy in the management of the pulmonary metastases of gestational choriocarcinoma. (1212836)
1975
42
Gestational choriocarcinoma of the tube and ovary. (4730067)
1973
43
Invasive mole and gestational choriocarcinoma in Denmark, 1940-1969. Biological and clinical aspects. (4355252)
1973
44
Chemotherapy of gestational choriocarcinoma. (4641760)
1972
45
Gestational choriocarcinoma. (5065688)
1972
46
Invasive mole, gestational choriocarcinoma and transplantation antigens. (4364364)
1972
47
Chemotherapy of gestational choriocarcinoma: a preliminary report of eight patients treated with methotrexate. (5168900)
1971
48
Extrauterine gestational choriocarcinoma. Report of two cases. (5441265)
1970
49
Histocompatibility antigens on the HL-A locus in gestational choriocarcinoma. (5406845)
1969
50
Gestational choriocarcinoma in the General Hospital of Mexico. Analysis of forty cases. (5659418)
1968

Variations for Gestational Choriocarcinoma

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Expression for genes affiliated with Gestational Choriocarcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gestational Choriocarcinoma

Search GEO for disease gene expression data for Gestational Choriocarcinoma.

Pathways for genes affiliated with Gestational Choriocarcinoma

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database
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Pathways related to Gestational Choriocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CGB5, ENPEP

Compounds for genes affiliated with Gestational Choriocarcinoma

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB, 62Tocris Bioscience
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Compounds related to Gestational Choriocarcinoma according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1indoleamine4610.1IFNG, CGB5
2oestriol4610.1CGB5, CGB7
3ctp4610.1CGB7, CGB5
4l-nmma4610.1CGB5, IFNG
57,8-dihydroneopterin46 2511.0ALPP, IFNG
6zoledronic acid4610.0IFNG, ALPP
7aphidicolin4610.0ALPP, IFNG
8bleomycin46 1210.9CGB5, CGB7
9pge1469.8ALPP, CGB5
10progestin469.8CGB5, ALPP
11hydroxyurea46 52 1211.8CGB5, ALPP
12prednisolone46 30 1211.8ALPP, IFNG
13sodium dodecylsulfate469.7CGB5, ALPP
14hydrocortisone46 3 62 1212.7IFNG, ALPP
15succinate469.6ALPP, ENPEP
16thyroxine46 2510.6CGB7, ALPP
17nifedipine46 30 52 1212.5CGB5, ALPP
18genistein46 30 62 3 25 1214.5CGB5, ALPP, IFNG
19cyclosporin a46 30 6211.5IFNG, ALPP, CGB5
20pge2469.5CGB5, ALPP, IFNG
21lactate469.5ALPP, CGB7, CGB5
22cycloheximide469.5CGB5, ALPP, IFNG
23cisplatin46 52 62 1212.5CGB5, CGB7, ALPP
24ibmx46 62 3011.4CGB5, ALPP
25testosterone46 62 25 1212.4ALPP, CGB7, CGB5
26dexamethasone46 52 30 1212.3CGB5, ALPP, IFNG
27simvastatin46 52 62 30 25 1214.3ALPP, IFNG
28retinoic acid46 2510.2IFNG, ALPP, CGB7, CGB5
29vegf469.0CGB5, ENPEP, ALPP, IFNG
30arginine468.9CGB5, ENPEP, ALPP, IFNG

GO Terms for genes affiliated with Gestational Choriocarcinoma

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Products for genes affiliated with Gestational Choriocarcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gestational Choriocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet