MCID: GST052
MIFTS: 41

Gestational Choriocarcinoma

Categories: Reproductive diseases, Rare diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Gestational Choriocarcinoma

MalaCards integrated aliases for Gestational Choriocarcinoma:

Name: Gestational Choriocarcinoma 12 56 14 69
Molar Pregnancy with Choriocarcinoma 12
Gestational Chorionepithelioma 12

Characteristics:

Orphanet epidemiological data:

56
gestational choriocarcinoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:2025
NCIt 47 C4646
Orphanet 56 ORPHA99926
UMLS via Orphanet 70 C0349557
ICD10 via Orphanet 34 C58
UMLS 69 C0349557

Summaries for Gestational Choriocarcinoma

MalaCards based summary : Gestational Choriocarcinoma, also known as molar pregnancy with choriocarcinoma, is related to non-gestational choriocarcinoma and fallopian tube gestational choriocarcinoma. An important gene associated with Gestational Choriocarcinoma is IFNG (Interferon Gamma), and among its related pathways/superpathways are Toll Comparative Pathway and Tuberculosis. The drugs Chorionic Gonadotropin and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and placenta.

Wikipedia : 72 Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event... more...

Related Diseases for Gestational Choriocarcinoma

Diseases related to Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 non-gestational choriocarcinoma 12.2
2 fallopian tube gestational choriocarcinoma 12.1
3 primary non-gestational choriocarcinoma of ovary 12.0
4 gestational trophoblastic tumor 11.2
5 choriocarcinoma 10.8
6 lymphocytic colitis 10.4 IFNG SLC6A4
7 traumatic glaucoma 10.2 ABCG2 CSH1
8 ectopic pregnancy 10.1
9 subclavian steal syndrome 10.1 CALM1 CALM3
10 long qt syndrome 15 10.1 CALM1 CALM3
11 epidural spinal canal meningioma 10.0 CALM1 CALM3
12 heterotaxy, visceral, 8, autosomal 10.0 CALM1 CALM3
13 pseudohypoaldosteronism, type iic 10.0 CALM1 CALM3
14 mononeuritis of lower limb 10.0 CALM1 CALM3
15 pontiac fever 10.0 CALM1 CALM3
16 regular astigmatism 10.0 CALM1 CALM3
17 adenocarcinoma 10.0
18 invasive mole 10.0
19 bulimia nervosa, age of onset of weight loss in 10.0 CALM1 CALM3
20 leber congenital amaurosis 2 10.0 CALM1 CALM3
21 alkhurma hemorrhagic fever 9.9 CALM1 CALM3
22 cardiomyopathy, dilated, 1a 9.9 CALM1 CALM3
23 cardiomyopathy, hypertrophic, 18 9.9 CALM1 CALM3
24 choroiditis 9.8
25 dumping syndrome 9.8 CALM1 CALM3 IFNG
26 partial of retinal vein occlusion 9.8 CALM1 CALM3
27 anxiety disorder 9.7 ABCG2 SLC6A4
28 plantar fasciitis 9.7 CALM1 CALM3
29 lymphocytic choriomeningitis 9.7 CALM1 CALM3
30 cerebritis 9.7
31 tuberculosis 9.7
32 choriocarcinoma of ovary 9.7
33 intussusception 9.7
34 pulmonary hypertension 9.7
35 germ cells tumors 9.7
36 hepatitis 9.7
37 infective endocarditis 9.7
38 malignant germ cell tumor 9.7
39 aneurysm 9.7
40 endocarditis 9.7
41 cerebral aneurysms 9.7
42 leiomyoma 9.7
43 pulmonary tuberculosis 9.7
44 hairy cell leukemia 9.7 CALM1 CALM3 ENPEP
45 deafness, autosomal dominant 2a 9.6 CALM1 CALM3
46 encephalomalacia 5.9 ABCG2 CALM1 CALM3 CRYGC CSH1 ENPEP

Graphical network of the top 20 diseases related to Gestational Choriocarcinoma:



Diseases related to Gestational Choriocarcinoma

Symptoms & Phenotypes for Gestational Choriocarcinoma

Drugs & Therapeutics for Gestational Choriocarcinoma

Drugs for Gestational Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chorionic Gonadotropin Phase 4
2
Dactinomycin Approved Phase 3 50-76-0 2019 457193
3
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
4
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
5
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Palivizumab Approved, Investigational Phase 3 188039-54-5
8
Ribavirin Approved Phase 3 36791-04-5 37542
9
Levoleucovorin Approved Phase 3,Phase 2 68538-85-2
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
11
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
12 Anti-Bacterial Agents Phase 3
13 Antibiotics, Antitubercular Phase 3
14 Anti-Infective Agents Phase 3,Phase 2
15 Antimetabolites Phase 3,Phase 2
16 Antimetabolites, Antineoplastic Phase 3,Phase 2
17 Antirheumatic Agents Phase 3,Phase 2
18 Dermatologic Agents Phase 3,Phase 2
19 Folic Acid Antagonists Phase 3,Phase 2
20 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
21 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
22 Vitamin B Complex Phase 3,Phase 2
23 Antifungal Agents Phase 3
24 Antiparasitic Agents Phase 3
25 Antiprotozoal Agents Phase 3
26 Echinocandins Phase 3
27 Liposomal amphotericin B Phase 3
28 Antibodies Phase 3,Phase 2
29 Antibodies, Monoclonal Phase 3,Phase 2
30 Antiviral Agents Phase 3,Phase 2
31 Immunoglobulins Phase 3,Phase 2
32 Antidotes Phase 3,Phase 2
33 Bone Density Conservation Agents Phase 3
34 Calcium, Dietary Phase 3
35 Micronutrients Phase 3,Phase 2
36 Protective Agents Phase 3,Phase 2
37 Trace Elements Phase 3,Phase 2
38 Vitamins Phase 3,Phase 2
39 Hematinics Phase 2, Phase 3
40 Folate Nutraceutical Phase 3,Phase 2
41 Vitamin B9 Nutraceutical Phase 3,Phase 2
42
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 446556 60843
43
Lenograstim Approved Phase 2 135968-09-1
44
Oprelvekin Approved, Investigational Phase 2 145941-26-0
45
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
46
Bevacizumab Approved, Investigational Phase 2 216974-75-3
47
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
48
nivolumab Approved Phase 2 946414-94-4
49 Adjuvants, Immunologic Phase 2,Phase 1
50 Anti-Asthmatic Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 20)

id Name Status NCT ID Phase Drugs
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3 Methotrexate
3 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
4 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
5 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
6 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01535053 Phase 3 Leucovorin Calcium;Methotrexate
7 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
8 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2 Pemetrexed
9 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
10 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
11 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
12 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
13 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
14 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2 TRC105;Bevacizumab
15 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
16 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
17 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
18 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
19 The French National Reference Centre of GTD Recruiting NCT02892877
20 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355

Search NIH Clinical Center for Gestational Choriocarcinoma

Genetic Tests for Gestational Choriocarcinoma

Anatomical Context for Gestational Choriocarcinoma

MalaCards organs/tissues related to Gestational Choriocarcinoma:

39
Ovary, Bone, Placenta, Colon, Breast, Bone Marrow, Cervix

Publications for Gestational Choriocarcinoma

Articles related to Gestational Choriocarcinoma:

(show top 50) (show all 162)
id Title Authors Year
1
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature. ( 28728581 )
2017
2
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. ( 28830246 )
2017
3
Metastatic gestational choriocarcinoma: a masquerader in obstetrics. ( 28550508 )
2017
4
Gestational choriocarcinoma complicated by infective endocarditis during chemotherapy. ( 28217736 )
2017
5
An unusual pulmonary metastatic manifestation of gestational choriocarcinoma: A diagnostic dilemma. ( 28869244 )
2017
6
An extremely rare case of postpartum gestational choriocarcinoma with long-term survival. ( 28777426 )
2017
7
Gestational choriocarcinoma associated with a germline TP53 mutation. ( 28477316 )
2017
8
Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy: a report of five cases. ( 28607811 )
2017
9
Disseminated gestational choriocarcinoma presenting with hepatic and uveal metastases, hook effect, and choriocarcinoma syndrome. ( 28104943 )
2016
10
Gestational choriocarcinoma with renal and pulmonary metastases lacking a primary uterine origin. ( 28040140 )
2016
11
Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings. ( 27095467 )
2016
12
Solitary lung metastasis from gestational choriocarcinoma resected six years after hydatidiform mole: A case report. ( 27744215 )
2016
13
Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy. ( 27987335 )
2016
14
Ectopic pregnancy with associated gestational choriocarcinoma in a California sea lion (Zalophus californianus). ( 27409239 )
2016
15
Intussusception in gestational choriocarcinoma (not histologically proven), resolving spontaneously with chemotherapy. ( 26420692 )
2015
16
A retrospective study to evaluate single agent methotrexate treatment in low risk gestational choriocarcinoma in the United Kingdom. ( 25542400 )
2015
17
Gestational choriocarcinoma with uterine serosal metastasis mimicking ruptured ectopic pregnancy: A case report. ( 26137037 )
2015
18
Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case. ( 26075121 )
2015
19
FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report. ( 26622776 )
2015
20
FIGO Stage III Metastatic Gestational Choriocarcinoma Developed From an Antecedent Partial Hydatidiform Molar Pregnancy Bearing a Numerical Chromosomal Aberration 68, XX: A Case Report and Literature Review. ( 26352546 )
2015
21
Gestational choriocarcinoma after term pregnancy: a case report. ( 25826515 )
2015
22
Gestational choriocarcinoma of the cervix. ( 25365622 )
2014
23
Gestational choriocarcinoma at Ibn Rochd Hospital, Casablanca, 2004-2010. ( 24995750 )
2014
24
Glycan profiling of gestational choriocarcinoma using a lectin microarray. ( 24424471 )
2014
25
Unusual gestational choriocarcinoma arising in an interstitial pregnancy. ( 25290382 )
2014
26
Coexistent gestational choriocarcinoma and mixed adenocarcinoma of the uterus. ( 24020150 )
2013
27
Treatment of gestational choriocarcinoma and massive ascites by hypothermic intraperitoneal perfusion chemotherapy guided by ultrasound followed by cytoreductive surgery. ( 24353600 )
2013
28
Gestational choriocarcinoma in the fallopian tube. ( 24219747 )
2013
29
Gestational Choriocarcinoma Metastasis to the Extraocular Muscle: A Case Report. ( 23924991 )
2013
30
Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma. ( 24163669 )
2013
31
Hypersensitivity to Etoposide in case of metastatic gestational choriocarcinoma. ( 24163666 )
2013
32
An unusual cause of lower GI bleeding in a young woman: metastatic gestational choriocarcinoma. ( 22421497 )
2013
33
Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses. ( 23202784 )
2013
34
Gestational choriocarcinoma in liver mimicking ruptured ectopic pregnancy. ( 22663336 )
2012
35
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. ( 22053686 )
2011
36
Gestational choriocarcinoma of Fallopian tube diagnosed with a combination of p57KIP2 immunostaining and short tandem repeat analysis: case report. ( 21599798 )
2011
37
Trophoblastic vasculogenic mimicry in gestational choriocarcinoma. ( 21217646 )
2011
38
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. ( 24371601 )
2011
39
Gestational choriocarcinoma presenting as hemothorax. ( 22842324 )
2010
40
Gestational choriocarcinoma analyzed by polymerase chain reaction amplification of polymorphic VNTR and human leukocyte antigen regions. ( 20435306 )
2010
41
Gestational choriocarcinoma transmission following multiorgan donation. ( 20977645 )
2010
42
A case of primary tubal gestational choriocarcinoma. ( 20522081 )
2010
43
Gestational choriocarcinoma in one placenta of dichorionic diamniotic twins who showed severe anemia. ( 19608272 )
2009
44
Acute abdomen as initial presentation of gestational choriocarcinoma. ( 19288267 )
2009
45
A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman. ( 19809555 )
2009
46
Gestational choriocarcinoma diagnosed with spontaneous splenic rupture after pregnancy induced by in vitro fertilization: a case report. ( 19829989 )
2009
47
Gestational choriocarcinoma mimicking a uterine adenocarcinoma. ( 18838707 )
2008
48
Gestational choriocarcinoma: morphological features in a liquid-based endometrial cytological sample. ( 18181184 )
2008
49
Uterine gestational choriocarcinoma developing after a long latent period in a postmenopausal woman: the value of DNA polymorphism studies. ( 18417687 )
2008
50
Successful treatment of FIGO stage IV gestational choriocarcinoma occurring 2 months after delivery. ( 17521800 )
2008

Variations for Gestational Choriocarcinoma

Expression for Gestational Choriocarcinoma

Search GEO for disease gene expression data for Gestational Choriocarcinoma.

Pathways for Gestational Choriocarcinoma

Pathways related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.93 CALM1 CALM3 IFNG
2 11.91 CALM1 CALM3 IFNG
3 11.72 CALM1 CALM3 IFNG
4
Show member pathways
11.21 CALM1 CALM3 IFNG
5 11.14 CALM1 CALM3
6 11.13 CALM1 CALM3
7 11.11 CALM1 CALM3
8
Show member pathways
11.08 SLC6A6 SLC7A5
9 11.07 CALM1 CALM3
10 11.03 CALM1 CALM3
11 10.99 CALM1 CALM3
12 10.97 CALM1 CALM3
13 10.96 CALM1 CALM3
14
Show member pathways
10.92 CALM1 CALM3 IFNG
15
Show member pathways
10.81 CALM1 CALM3 IFNG
16 10.78 CALM1 CALM3
17 10.65 CALM1 CALM3
18 10.6 CALM1 CALM3
19 10.37 CALM1 CALM3

GO Terms for Gestational Choriocarcinoma

Cellular components related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium channel complex GO:0034704 8.96 CALM1 CALM3
2 mitochondrial membrane GO:0031966 8.32 ABCG2

Biological processes related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 regulation of heart rate GO:0002027 9.56 CALM1 CALM3
2 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.55 CALM1 CALM3
3 positive regulation of protein dephosphorylation GO:0035307 9.54 CALM1 CALM3
4 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.52 CALM1 CALM3
5 positive regulation of protein autophosphorylation GO:0031954 9.51 CALM1 CALM3
6 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.49 CALM1 CALM3
7 regulation of cardiac muscle contraction GO:0055117 9.48 CALM1 CALM3
8 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.46 CALM1 CALM3
9 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.43 CALM1 CALM3
10 detection of calcium ion GO:0005513 9.4 CALM1 CALM3
11 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.37 CALM1 CALM3
12 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.32 CALM1 CALM3
13 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.26 CALM1 CALM3
14 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.16 CALM1 CALM3
15 positive regulation of protein serine/threonine kinase activity GO:0071902 9.13 CALM1 CALM3 IFNG
16 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.62 CALM1 CALM3

Molecular functions related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein serine/threonine kinase activator activity GO:0043539 9.26 CALM1 CALM3
2 neurotransmitter:sodium symporter activity GO:0005328 9.16 SLC6A4 SLC6A6
3 titin binding GO:0031432 8.96 CALM1 CALM3
4 protein phosphatase activator activity GO:0072542 8.62 CALM1 CALM3

Sources for Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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