MCID: GST052
MIFTS: 39

Gestational Choriocarcinoma

Categories: Cancer diseases, Reproductive diseases, Rare diseases, Fetal diseases

Aliases & Classifications for Gestational Choriocarcinoma

MalaCards integrated aliases for Gestational Choriocarcinoma:

Name: Gestational Choriocarcinoma 12 55 14 69
Molar Pregnancy with Choriocarcinoma 12
Gestational Chorionepithelioma 12

Characteristics:

Orphanet epidemiological data:

55
gestational choriocarcinoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:2025
NCIt 46 C4646
Orphanet 55 ORPHA99926
UMLS via Orphanet 70 C0349557
ICD10 via Orphanet 33 C58
UMLS 69 C0349557

Summaries for Gestational Choriocarcinoma

MalaCards based summary : Gestational Choriocarcinoma, also known as molar pregnancy with choriocarcinoma, is related to fallopian tube gestational choriocarcinoma and non-gestational choriocarcinoma. An important gene associated with Gestational Choriocarcinoma is IFNG (Interferon Gamma), and among its related pathways/superpathways are Toll Comparative Pathway and Tuberculosis. Affiliated tissues include ovary, placenta and cervix.

Wikipedia : 72 Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event... more...

Related Diseases for Gestational Choriocarcinoma

Diseases related to Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 fallopian tube gestational choriocarcinoma 12.3
2 non-gestational choriocarcinoma 12.3
3 primary non-gestational choriocarcinoma of ovary 12.1
4 gestational trophoblastic tumor 11.3
5 choriocarcinoma 10.9
6 microscopic colitis 10.2 IFNG SLC6A4
7 ectopic pregnancy 10.2
8 hydatidiform mole, recurrent, 1 10.1
9 adenocarcinoma 10.1
10 invasive mole 10.1
11 persistent fetal circulation syndrome 10.1 ABCG2 CSH1
12 acute dacryocystitis 10.0 CALM1 CALM3
13 long qt syndrome 15 10.0 CALM1 CALM3
14 external ear disease 10.0 CALM1 CALM3
15 otitis externa 10.0 CALM1 CALM3
16 deafness, autosomal recessive 44 10.0 CALM1 CALM3
17 otomycosis 10.0 CALM1 CALM3
18 spontaneous ocular nystagmus 9.9 CALM1 CALM3
19 dystonia 24 9.9 CALM1 CALM3
20 choroiditis 9.9
21 triosephosphate isomerase deficiency 9.9 CALM1 CALM3
22 leber congenital amaurosis 2 9.9 CALM1 CALM3
23 placental choriocarcinoma 9.9 ABCG2 SLC6A4
24 cardiomyopathy, dilated, 1a 9.9 CALM1 CALM3
25 clear cell acanthoma 9.8 CALM1 CALM3
26 cardiomyopathy, dilated, 1p 9.8 CALM1 CALM3
27 sporotrichosis 9.8 CALM1 CALM3 IFNG
28 primary systemic mycosis 9.8 CALM1 CALM3 IFNG
29 intussusception 9.8
30 graves disease 1 9.8
31 aging 9.8
32 mycobacterium tuberculosis 1 9.8
33 pulmonary hypertension 9.8
34 hepatitis 9.8
35 infective endocarditis 9.8
36 endocarditis 9.8
37 allergic hypersensitivity disease 9.8
38 leiomyoma 9.8
39 pulmonary tuberculosis 9.8
40 cerebritis 9.8
41 choriocarcinoma of ovary 9.8
42 germ cells tumors 9.8
43 malignant germ cell tumor 9.8
44 aneurysm 9.8
45 cerebral aneurysms 9.8
46 deafness, autosomal dominant 2a 9.7 CALM1 CALM3
47 long qt syndrome 9.7 CALM1 CALM3 ENPEP
48 tuberous sclerosis 2 9.7 CALM1 IFNG

Graphical network of the top 20 diseases related to Gestational Choriocarcinoma:



Diseases related to Gestational Choriocarcinoma

Symptoms & Phenotypes for Gestational Choriocarcinoma

Drugs & Therapeutics for Gestational Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Gestational Choriocarcinoma

Genetic Tests for Gestational Choriocarcinoma

Anatomical Context for Gestational Choriocarcinoma

MalaCards organs/tissues related to Gestational Choriocarcinoma:

38
Ovary, Placenta, Cervix, Liver, Uterus, Lung, Brain

Publications for Gestational Choriocarcinoma

Articles related to Gestational Choriocarcinoma:

(show top 50) (show all 167)
# Title Authors Year
1
Nonmetastatic Excised Gestational Choriocarcinoma: To Treat or Not to Treat. ( 29406249 )
2018
2
Debulking Surgery for Pelvic Recurrence After Surgically-treated Tubal Gestational Choriocarcinoma - A Case Report and Literature Review. ( 29277804 )
2018
3
Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma. ( 29232272 )
2018
4
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. ( 28830246 )
2017
5
Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy: a report of five cases. ( 28607811 )
2017
6
An extremely rare case of postpartum gestational choriocarcinoma with long-term survival. ( 28777426 )
2017
7
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature. ( 28728581 )
2017
8
Gestational choriocarcinoma complicated by infective endocarditis during chemotherapy. ( 28217736 )
2017
9
Gestational choriocarcinoma associated with a germline TP53 mutation. ( 28477316 )
2017
10
A Rare Case of Gestational Choriocarcinoma Presenting as Cornual Ectopic Pregnancy. ( 29032067 )
2017
11
Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney. ( 29285373 )
2017
12
Metastatic gestational choriocarcinoma: a masquerader in obstetrics. ( 28550508 )
2017
13
An unusual pulmonary metastatic manifestation of gestational choriocarcinoma: A diagnostic dilemma. ( 28869244 )
2017
14
Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings. ( 27095467 )
2016
15
Gestational choriocarcinoma with renal and pulmonary metastases lacking a primary uterine origin. ( 28040140 )
2016
16
Ectopic pregnancy with associated gestational choriocarcinoma in a California sea lion (Zalophus californianus). ( 27409239 )
2016
17
Disseminated gestational choriocarcinoma presenting with hepatic and uveal metastases, hook effect, and choriocarcinoma syndrome. ( 28104943 )
2016
18
Solitary lung metastasis from gestational choriocarcinoma resected six years after hydatidiform mole: A case report. ( 27744215 )
2016
19
Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy. ( 27987335 )
2016
20
Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case. ( 26075121 )
2015
21
Gestational choriocarcinoma with uterine serosal metastasis mimicking ruptured ectopic pregnancy: A case report. ( 26137037 )
2015
22
FIGO Stage III Metastatic Gestational Choriocarcinoma Developed From an Antecedent Partial Hydatidiform Molar Pregnancy Bearing a Numerical Chromosomal Aberration 68, XX: A Case Report and Literature Review. ( 26352546 )
2015
23
Intussusception in gestational choriocarcinoma (not histologically proven), resolving spontaneously with chemotherapy. ( 26420692 )
2015
24
FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report. ( 26622776 )
2015
25
A retrospective study to evaluate single agent methotrexate treatment in low risk gestational choriocarcinoma in the United Kingdom. ( 25542400 )
2015
26
Gestational choriocarcinoma after term pregnancy: a case report. ( 25826515 )
2015
27
Unusual gestational choriocarcinoma arising in an interstitial pregnancy. ( 25290382 )
2014
28
Glycan profiling of gestational choriocarcinoma using a lectin microarray. ( 24424471 )
2014
29
Gestational choriocarcinoma of the cervix. ( 25365622 )
2014
30
Gestational choriocarcinoma at Ibn Rochd Hospital, Casablanca, 2004-2010. ( 24995750 )
2014
31
Coexistent gestational choriocarcinoma and mixed adenocarcinoma of the uterus. ( 24020150 )
2013
32
Hypersensitivity to Etoposide in case of metastatic gestational choriocarcinoma. ( 24163666 )
2013
33
Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses. ( 23202784 )
2013
34
Treatment of gestational choriocarcinoma and massive ascites by hypothermic intraperitoneal perfusion chemotherapy guided by ultrasound followed by cytoreductive surgery. ( 24353600 )
2013
35
Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma. ( 24163669 )
2013
36
Gestational Choriocarcinoma Metastasis to the Extraocular Muscle: A Case Report. ( 23924991 )
2013
37
Gestational choriocarcinoma in the fallopian tube. ( 24219747 )
2013
38
An unusual cause of lower GI bleeding in a young woman: metastatic gestational choriocarcinoma. ( 22421497 )
2013
39
Gestational choriocarcinoma in liver mimicking ruptured ectopic pregnancy. ( 22663336 )
2012
40
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. ( 24371601 )
2011
41
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. ( 22053686 )
2011
42
Trophoblastic vasculogenic mimicry in gestational choriocarcinoma. ( 21217646 )
2011
43
Gestational choriocarcinoma of Fallopian tube diagnosed with a combination of p57KIP2 immunostaining and short tandem repeat analysis: case report. ( 21599798 )
2011
44
Gestational choriocarcinoma transmission following multiorgan donation. ( 20977645 )
2010
45
Gestational choriocarcinoma analyzed by polymerase chain reaction amplification of polymorphic VNTR and human leukocyte antigen regions. ( 20435306 )
2010
46
Gestational choriocarcinoma presenting as hemothorax. ( 22842324 )
2010
47
A case of primary tubal gestational choriocarcinoma. ( 20522081 )
2010
48
Gestational choriocarcinoma diagnosed with spontaneous splenic rupture after pregnancy induced by in vitro fertilization: a case report. ( 19829989 )
2009
49
Gestational choriocarcinoma in one placenta of dichorionic diamniotic twins who showed severe anemia. ( 19608272 )
2009
50
Acute abdomen as initial presentation of gestational choriocarcinoma. ( 19288267 )
2009

Variations for Gestational Choriocarcinoma

Expression for Gestational Choriocarcinoma

Search GEO for disease gene expression data for Gestational Choriocarcinoma.

Pathways for Gestational Choriocarcinoma

Pathways related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.93 CALM1 CALM3 IFNG
2 11.91 CALM1 CALM3 IFNG
3 11.72 CALM1 CALM3 IFNG
4
Show member pathways
11.21 CALM1 CALM3 IFNG
5 11.14 CALM1 CALM3
6 11.13 CALM1 CALM3
7 11.11 CALM1 CALM3
8
Show member pathways
11.08 SLC6A6 SLC7A5
9 11.07 CALM1 CALM3
10 11.03 CALM1 CALM3
11 10.99 CALM1 CALM3
12 10.97 CALM1 CALM3
13 10.96 CALM1 CALM3
14
Show member pathways
10.92 CALM1 CALM3 IFNG
15
Show member pathways
10.81 CALM1 CALM3 IFNG
16 10.78 CALM1 CALM3
17 10.65 CALM1 CALM3
18 10.6 CALM1 CALM3
19 10.37 CALM1 CALM3

GO Terms for Gestational Choriocarcinoma

Cellular components related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 9.33 CALM1 CALM3 CSH1
2 calcium channel complex GO:0034704 8.96 CALM1 CALM3
3 catalytic complex GO:1902494 8.62 CALM1 CALM3

Biological processes related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of heart rate GO:0002027 9.57 CALM1 CALM3
2 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.56 CALM1 CALM3
3 regulation of cytokinesis GO:0032465 9.55 CALM1 CALM3
4 positive regulation of protein autophosphorylation GO:0031954 9.54 CALM1 CALM3
5 positive regulation of protein dephosphorylation GO:0035307 9.52 CALM1 CALM3
6 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.51 CALM1 CALM3
7 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.49 CALM1 CALM3
8 regulation of cardiac muscle contraction GO:0055117 9.48 CALM1 CALM3
9 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.46 CALM1 CALM3
10 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.43 CALM1 CALM3
11 detection of calcium ion GO:0005513 9.4 CALM1 CALM3
12 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.37 CALM1 CALM3
13 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.32 CALM1 CALM3
14 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.26 CALM1 CALM3
15 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.16 CALM1 CALM3
16 positive regulation of protein serine/threonine kinase activity GO:0071902 9.13 CALM1 CALM3 IFNG
17 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.62 CALM1 CALM3

Molecular functions related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.4 CALM1 CALM3
2 protein serine/threonine kinase activator activity GO:0043539 9.37 CALM1 CALM3
3 neurotransmitter:sodium symporter activity GO:0005328 9.32 SLC6A4 SLC6A6
4 titin binding GO:0031432 9.26 CALM1 CALM3
5 adenylate cyclase binding GO:0008179 9.16 CALM1 CALM3
6 protein phosphatase activator activity GO:0072542 8.96 CALM1 CALM3
7 N-terminal myristoylation domain binding GO:0031997 8.62 CALM1 CALM3

Sources for Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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