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MCID: GST052
MIFTS: 42

Gestational Choriocarcinoma malady

Categories: Reproductive diseases, Rare diseases, Cancer diseases, Fetal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Gestational Choriocarcinoma

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Aliases & Descriptions for Gestational Choriocarcinoma:

Name: Gestational Choriocarcinoma 12 56 14 69
Molar Pregnancy with Choriocarcinoma 12
Gestational Chorionepithelioma 12

Characteristics:

Orphanet epidemiological data:

56
gestational choriocarcinoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Fetal diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 56  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:2025
NCIt 47 C4646
Orphanet 56 ORPHA99926
UMLS via Orphanet 70 C0349557
ICD10 via Orphanet 34 C58
UMLS 69 C0349557
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Summaries for Gestational Choriocarcinoma

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MalaCards based summary : Gestational Choriocarcinoma, also known as molar pregnancy with choriocarcinoma, is related to non-gestational choriocarcinoma and fallopian tube gestational choriocarcinoma. An important gene associated with Gestational Choriocarcinoma is IFNG (Interferon Gamma), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll Comparative Pathway. The drugs Chorionic Gonadotropin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include placenta, ovary and cervix.

Wikipedia : 71 Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event... more...

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Related Diseases for Gestational Choriocarcinoma

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Diseases related to Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
id Related Disease Score Top Affiliating Genes
1 non-gestational choriocarcinoma 12.2
2 fallopian tube gestational choriocarcinoma 12.1
3 primary non-gestational choriocarcinoma of ovary 12.0
4 choriocarcinoma 10.8
5 bleeding disorder, platelet-type, 15 10.1 CALM1 CALM3
6 microphthalmia with limb anomalies 10.1 CALM1 CALM3
7 ectopic pregnancy 10.1
8 subclavian steal syndrome 10.1 CALM1 CALM3
9 leukemia, acute lymphoblastic 2 10.1 CALM1 CALM3
10 short stature with microcephaly and distinctive facies 10.1 CALM1 CALM3
11 neuropathy, hereditary sensory and autonomic, type ii 10.1 CALM1 CALM3
12 dumping syndrome 10.1 CALM1 CALM3
13 arthropathy 10.1 CALM1 CALM3
14 toxic encephalopathy 10.1 CDKN1C CSH1
15 chronic dacryoadenitis 10.1 CALM1 CALM3
16 retinitis pigmentosa 20 10.1 CALM1 CALM3
17 regular astigmatism 10.1 CALM1 CALM3
18 anus leiomyosarcoma 10.1 B2M ENPEP IFNG
19 aspiration pneumonia 10.1 CALM1 CALM3
20 familial sick sinus syndrome 10.0 CALM1 CALM3
21 lipodystrophy, familial partial, 2 10.0 CALM1 CALM3
22 invasive mole 10.0
23 ciliary dyskinesia, primary, 11 10.0 CALM1 CALM3
24 ovarian mucinous cystadenocarcinoma 10.0 CDKN1C CSH1 SLC6A4
25 clostridium difficile colitis 10.0 IFNG SLC6A4
26 laryngomalacia 10.0 B2M CDKN1C
27 deafness, autosomal dominant 2a 9.9 CALM1 CALM3
28 hutchinson incisors 9.9 ADAR IFNG
29 adenocarcinoma 9.9
30 acantholytic acanthoma 9.9 ADAR B2M CSH1
31 choroiditis 9.8
32 leiomyoma 9.7
33 pulmonary tuberculosis 9.7
34 cerebritis 9.7
35 tuberculosis 9.7
36 choriocarcinoma of ovary 9.7
37 intussusception 9.7
38 malignant germ cell tumor 9.7
39 aneurysm 9.7
40 cerebral aneurysms 9.7
41 pulmonary hypertension 9.7
42 encephalomalacia 8.5 ADAR B2M CALM1 CALM3 CDKN1C CRYGC

Graphical network of the top 20 diseases related to Gestational Choriocarcinoma:



Diseases related to Gestational Choriocarcinoma
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Symptoms & Phenotypes for Gestational Choriocarcinoma

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Drugs & Therapeutics for Gestational Choriocarcinoma

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Drugs for Gestational Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chorionic Gonadotropin Phase 4
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Captopril Approved Phase 3 62571-86-2 44093
5
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
6
Ribavirin Approved Phase 3 36791-04-5 37542
7
Fluconazole Approved Phase 3 86386-73-4 3365
8
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
9
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
10
Dactinomycin Approved Phase 3 50-76-0 2019 457193
11
Palivizumab Approved, Investigational Phase 3 188039-54-5
12
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
13
Levoleucovorin Approved Phase 3 68538-85-2
14
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
16 Hydroxyitraconazole Phase 3
17 Alkylating Agents Phase 3
18
protease inhibitors Phase 3
19 Folic Acid Antagonists Phase 3,Phase 2
20 Steroid Synthesis Inhibitors Phase 3
21 HIV Protease Inhibitors Phase 3
22 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
23 Cytochrome P-450 CYP3A Inhibitors Phase 3
24 Cytochrome P-450 Enzyme Inhibitors Phase 3
25 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
26 Dermatologic Agents Phase 3
27 Hormone Antagonists Phase 3,Phase 1,Phase 2
28 Hormones Phase 3,Phase 1,Phase 2
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
30 Echinocandins Phase 3
31 Angiotensin-Converting Enzyme Inhibitors Phase 3
32 Vitamin B Complex Phase 3,Phase 2
33 Anti-Bacterial Agents Phase 3
34 Immunoglobulins Phase 3,Phase 2
35 Anti-Infective Agents Phase 3,Phase 2
36 Antibodies, Monoclonal Phase 3,Phase 2
37 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
38 Antifungal Agents Phase 3
39 Antihypertensive Agents Phase 3
40 Antimetabolites Phase 3
41 Liposomal amphotericin B Phase 3
42 Antibiotics, Antitubercular Phase 3
43 Antimetabolites, Antineoplastic Phase 3
44 Antibodies Phase 3,Phase 2
45 Antirheumatic Agents Phase 3
46 Antineoplastic Agents, Alkylating Phase 3
47 Antiviral Agents Phase 3,Phase 2
48 Antiparasitic Agents Phase 3
49 Antiprotozoal Agents Phase 3
50 Hematinics Phase 3

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3
3 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
4 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
5 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
6 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
7 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
8 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01535053 Phase 3
9 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2
10 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
11 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
12 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2
13 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
14 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
15 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
16 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2
17 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
18 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
19 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
20 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
21 The French National Reference Centre of GTD Recruiting NCT02892877
22 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355

Search NIH Clinical Center for Gestational Choriocarcinoma

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Genetic Tests for Gestational Choriocarcinoma

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Anatomical Context for Gestational Choriocarcinoma

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MalaCards organs/tissues related to Gestational Choriocarcinoma:

39
Placenta, Ovary, Cervix, Liver, Lung, Brain, Uterus
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Publications for Gestational Choriocarcinoma

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Articles related to Gestational Choriocarcinoma:

(show top 50) (show all 153)
id Title Authors Year
1
Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy. ( 27987335 )
2016
2
Ectopic pregnancy with associated gestational choriocarcinoma in a California sea lion (Zalophus californianus). ( 27409239 )
2016
3
Solitary lung metastasis from gestational choriocarcinoma resected six years after hydatidiform mole: A case report. ( 27744215 )
2016
4
Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings. ( 27095467 )
2016
5
Gestational choriocarcinoma with renal and pulmonary metastases lacking a primary uterine origin. ( 28040140 )
2016
6
Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case. ( 26075121 )
2015
7
Gestational choriocarcinoma with uterine serosal metastasis mimicking ruptured ectopic pregnancy: A case report. ( 26137037 )
2015
8
A retrospective study to evaluate single agent methotrexate treatment in low risk gestational choriocarcinoma in the United Kingdom. ( 25542400 )
2015
9
FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report. ( 26622776 )
2015
10
FIGO Stage III Metastatic Gestational Choriocarcinoma Developed From an Antecedent Partial Hydatidiform Molar Pregnancy Bearing a Numerical Chromosomal Aberration 68, XX: A Case Report and Literature Review. ( 26352546 )
2015
11
Intussusception in gestational choriocarcinoma (not histologically proven), resolving spontaneously with chemotherapy. ( 26420692 )
2015
12
Gestational choriocarcinoma after term pregnancy: a case report. ( 25826515 )
2015
13
Gestational choriocarcinoma at Ibn Rochd Hospital, Casablanca, 2004-2010. ( 24995750 )
2014
14
Glycan profiling of gestational choriocarcinoma using a lectin microarray. ( 24424471 )
2014
15
Gestational choriocarcinoma of the cervix. ( 25365622 )
2014
16
Unusual gestational choriocarcinoma arising in an interstitial pregnancy. ( 25290382 )
2014
17
Gestational choriocarcinoma in the fallopian tube. ( 24219747 )
2013
18
Hypersensitivity to Etoposide in case of metastatic gestational choriocarcinoma. ( 24163666 )
2013
19
Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma. ( 24163669 )
2013
20
An unusual cause of lower GI bleeding in a young woman: metastatic gestational choriocarcinoma. ( 22421497 )
2013
21
Treatment of gestational choriocarcinoma and massive ascites by hypothermic intraperitoneal perfusion chemotherapy guided by ultrasound followed by cytoreductive surgery. ( 24353600 )
2013
22
Gestational Choriocarcinoma Metastasis to the Extraocular Muscle: A Case Report. ( 23924991 )
2013
23
Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses. ( 23202784 )
2013
24
Coexistent gestational choriocarcinoma and mixed adenocarcinoma of the uterus. ( 24020150 )
2013
25
Gestational choriocarcinoma in liver mimicking ruptured ectopic pregnancy. ( 22663336 )
2012
26
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. ( 24371601 )
2011
27
Trophoblastic vasculogenic mimicry in gestational choriocarcinoma. ( 21217646 )
2011
28
Gestational choriocarcinoma of Fallopian tube diagnosed with a combination of p57KIP2 immunostaining and short tandem repeat analysis: case report. ( 21599798 )
2011
29
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. ( 22053686 )
2011
30
Gestational choriocarcinoma analyzed by polymerase chain reaction amplification of polymorphic VNTR and human leukocyte antigen regions. ( 20435306 )
2010
31
Gestational choriocarcinoma presenting as hemothorax. ( 22842324 )
2010
32
A case of primary tubal gestational choriocarcinoma. ( 20522081 )
2010
33
Gestational choriocarcinoma transmission following multiorgan donation. ( 20977645 )
2010
34
Acute abdomen as initial presentation of gestational choriocarcinoma. ( 19288267 )
2009
35
Gestational choriocarcinoma in one placenta of dichorionic diamniotic twins who showed severe anemia. ( 19608272 )
2009
36
A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman. ( 19809555 )
2009
37
Gestational choriocarcinoma diagnosed with spontaneous splenic rupture after pregnancy induced by in vitro fertilization: a case report. ( 19829989 )
2009
38
Diagnostic dilemma: non-gestational or gestational choriocarcinoma of the ovary. ( 19322987 )
2008
39
Gestational choriocarcinoma mimicking a uterine adenocarcinoma. ( 18838707 )
2008
40
Uterine gestational choriocarcinoma developing after a long latent period in a postmenopausal woman: the value of DNA polymorphism studies. ( 18417687 )
2008
41
Successful treatment of FIGO stage IV gestational choriocarcinoma occurring 2 months after delivery. ( 17521800 )
2008
42
Gestational choriocarcinoma: morphological features in a liquid-based endometrial cytological sample. ( 18181184 )
2008
43
Power of the eternal youth: Nanog expression in the gestational choriocarcinoma. ( 18755845 )
2008
44
Gestational choriocarcinoma arising from a cornual ectopic pregnancy: a case report and review of the literature. ( 17581760 )
2007
45
Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature. ( 17309671 )
2007
46
Primary non-gestational choriocarcinoma of the lung. ( 18097929 )
2007
47
Intracerebral hemorrhage as initial presentation of gestational choriocarcinoma: a case report and literature review. ( 17425677 )
2007
48
St. Jude Children's Research Hospital, Memphis, Tennessee: gestational choriocarcinoma. ( 16220549 )
2006
49
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. ( 16984618 )
2006
50
Detection of non-maternal components of gestational choriocarcinoma by PCR-based microsatellite DNA assay. ( 16740299 )
2006
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Variations for Gestational Choriocarcinoma

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Expression for Gestational Choriocarcinoma

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Search GEO for disease gene expression data for Gestational Choriocarcinoma.
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Pathways for Gestational Choriocarcinoma

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Pathways related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 62
Show member pathways
 12.84 ADAR B2M CALM1 CALM3 CSH1 IFNG
2
Toll Comparative Pathway 60
Show member pathways
 11.95 CALM1 CALM3 IFNG
3
Tuberculosis 37
11.92 CALM1 CALM3 IFNG
4
Fluid shear stress and atherosclerosis 37
11.75 CALM1 CALM3 IFNG
5
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.21 CALM1 CALM3 IFNG
6
Immune response IFN gamma signaling pathway 21
Show member pathways
 11.14 CALM1 CALM3 IFNG
7
Nur77 Signaling in T-Cell 60
11.11 CALM1 CALM3
8
N-cadherin signaling events 1
11.08 CALM1 CALM3
9
Lissencephaly gene (LIS1) in neuronal migration and development 1
11.04 CALM1 CALM3
10
Insulin-mediated glucose transport 1
11 CALM1 CALM3
11
nNOS Signaling at Neuronal Synapses 60
10.99 CALM1 CALM3
12
p38 MAPK signaling pathway (Pathway Interaction Database) 1
10.97 CALM1 CALM3
13
Cellular roles of Anthrax toxin 1
10.8 CALM1 CALM3
14
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 10.71 B2M CALM1 CALM3 IFNG
15
Protein methylation 62
10.68 CALM1 CALM3
16
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 1
10.65 CALM1 CALM3
17
RHO GTPases activate IQGAPs 62
10.44 CALM1 CALM3
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GO Terms for Gestational Choriocarcinoma

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Cellular components related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 9.13 CALM1 CALM3 CSH1
2 calcium channel complex GO:0034704 8.62 CALM1 CALM3

Biological processes related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 regulation of heart rate GO:0002027 9.59 CALM1 CALM3
2 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.58 CALM1 CALM3
3 regulation of rhodopsin mediated signaling pathway GO:0022400 9.58 CALM1 CALM3
4 regulation of nitric-oxide synthase activity GO:0050999 9.57 CALM1 CALM3
5 positive regulation of protein autophosphorylation GO:0031954 9.56 CALM1 CALM3
6 regulation of cytokinesis GO:0032465 9.55 CALM1 CALM3
7 regulation of cardiac muscle contraction GO:0055117 9.54 CALM1 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.52 CALM1 CALM3
9 glycogen catabolic process GO:0005980 9.51 CALM1 CALM3
10 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.49 CALM1 CALM3
11 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.48 CALM1 CALM3
12 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.46 CALM1 CALM3
13 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.43 CALM1 CALM3
14 detection of calcium ion GO:0005513 9.4 CALM1 CALM3
15 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.37 CALM1 CALM3
16 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.32 CALM1 CALM3
17 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.26 CALM1 CALM3
18 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.16 CALM1 CALM3
19 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.96 CALM1 CALM3
20 positive regulation of protein serine/threonine kinase activity GO:0071902 8.8 CALM1 CALM3 IFNG

Molecular functions related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein serine/threonine kinase activator activity GO:0043539 9.43 CALM1 CALM3
2 phospholipase binding GO:0043274 9.4 CALM1 CALM3
3 nitric-oxide synthase binding GO:0050998 9.37 CALM1 SLC6A4
4 titin binding GO:0031432 9.32 CALM1 CALM3
5 thioesterase binding GO:0031996 9.26 CALM1 CALM3
6 inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440 9.16 CALM1 CALM3
7 protein phosphatase activator activity GO:0072542 8.96 CALM1 CALM3
8 N-terminal myristoylation domain binding GO:0031997 8.62 CALM1 CALM3
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Sources for Gestational Choriocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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