Aliases & Classifications for Gestational Diabetes

MalaCards integrated aliases for Gestational Diabetes:

Name: Gestational Diabetes 12 24 14 69 59
Diabetes Mellitus, Gestational 24 28 13
Gestational Diabetes Mellitus 12 72 24
Gdm 12 24 44
Maternal Gestational Diabetes Mellitus 12
Diabetes Mellitus Arising in Pregnancy 24
Diabetes Mellitus, Pregnancy Related 24
Diabetes, Pregnancy-Induced 24
Diabetes, Gestational 41
Diabetes Gestational 51

Classifications:



External Ids:

Disease Ontology 12 DOID:11714
ICD10 32 O24.4
MeSH 41 D016640
NCIt 46 C34942
UMLS 69 C0085207

Summaries for Gestational Diabetes

PubMed Health : 59
About gestational diabetes: Most women's blood sugar levels remain normal during pregnancy. But if blood sugar levels go above a certain value, they are considered to have gestational diabetes. This is the case in about 4 out of 100 women.It is not always clear whether a woman just has slightly higher blood sugar levels or whether she has gestational diabetes. Women’s metabolism changes over the course of pregnancy anyway: It takes longer for the cells in their body to absorb the sugar in their blood after meals. This means that elevated blood sugar levels are often a normal part of pregnancy – and they usually return to normal afterwards. Having gestational diabetes doesn’t mean that you have developed chronic diabetes.The raised blood sugar levels in gestational diabetes slightly increase the risk of certain rare birth complications. This risk can usually be lowered by changing your diet, though.The vast majority of women who develop gestational diabetes experience an otherwise normal pregnancy and go on to give birth to a healthy baby.

MalaCards based summary : Gestational Diabetes, also known as diabetes mellitus, gestational, is related to maturity-onset diabetes of the young, type 2 and fetal macrosomia, and has symptoms including morning sickness, pelvic pain and hyperemesis gravidarum. An important gene associated with Gestational Diabetes is GCK (Glucokinase), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Beta-Adrenergic Signaling. The drugs Resveratrol and Insulin Aspart have been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and placenta, and related phenotypes are homeostasis/metabolism and adipose tissue

Genetics Home Reference : 24 Gestational diabetes is a disorder characterized by abnormally high blood sugar levels during pregnancy. Affected women do not have diabetes before they are pregnant, and most of these women go back to being nondiabetic soon after the baby is born. The disease has a 30 to 70 percent chance of recurring in subsequent pregnancies. Additionally, about half of women with gestational diabetes develop another form of diabetes, known as type 2 diabetes, within a few years after their pregnancy.

Wikipedia : 72 Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels... more...

Related Diseases for Gestational Diabetes

Diseases related to Gestational Diabetes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 maturity-onset diabetes of the young, type 2 32.4 GCK INS
2 fetal macrosomia 31.0 INS INSR LEP
3 monogenic diabetes 30.4 GCK INS KCNJ11
4 polycystic ovary syndrome 30.1 INS INSR IRS1 LEP SHBG
5 apnea, obstructive sleep 30.1 ADIPOQ INS LEP
6 hypoglycemia 30.0 GCK INS INSR KCNJ11
7 sleep apnea 30.0 ADIPOQ INS LEP
8 severe pre-eclampsia 29.9 ADIPOQ LEP RBP4
9 hyperglycemia 29.8 ADIPOQ GCK INS INSR IRS1 KCNJ11
10 hyperinsulinemic hypoglycemia 29.8 GCK INS INSR KCNJ11
11 maturity-onset diabetes of the young 29.7 GCK INS IRS1 KCNJ11
12 acanthosis nigricans 29.7 ADIPOQ INS INSR LEP SHBG
13 hyperinsulinism 29.6 GCK INS INSR KCNJ11 LEP SHBG
14 diabetes mellitus 29.3 ADIPOQ ADRB3 GCK HKDC1 INS INSR
15 glucose intolerance 28.5 ADIPOQ ADRB3 GCK INS INSR IRS1
16 overnutrition 28.2 ADIPOQ ADRB3 INS IRS1 LEP NAMPT
17 body mass index quantitative trait locus 11 27.0 ADIPOQ ADIPOR1 ADRB3 GCK INS INSR
18 diabetes mellitus, noninsulin-dependent 24.7 ADIPOQ ADIPOR1 ADRB3 GCK INS INSR
19 gestational diabetes insipidus 12.2
20 congenital anomalies of kidney and urinary tract 2 10.9
21 diabetes mellitus, transient neonatal, 3 10.9
22 munchausen by proxy 10.5 GCK KCNJ11
23 insulin autoimmune syndrome 10.5 INS INSR
24 factitious disorder 10.5 GCK INS KCNJ11
25 body mass index quantitative trait locus 9 10.5
26 body mass index quantitative trait locus 8 10.5
27 body mass index quantitative trait locus 7 10.5
28 body mass index quantitative trait locus 12 10.5
29 body mass index quantitative trait locus 14 10.5
30 body mass index quantitative trait locus 18 10.5
31 acute insulin response 10.5 INS KCNJ11 TCF7L2
32 alstrom syndrome 10.4 INS KCNJ11 LEP
33 body mass index quantitative trait locus 4 10.4
34 body mass index quantitative trait locus 10 10.4
35 pancreatic agenesis 10.4 GCK INS KCNJ11
36 3-hydroxyacyl-coa dehydrogenase deficiency 10.4 ADIPOQ GCK INS
37 pancreas disease 10.4 INS KCNJ11 LEP
38 acquired generalized lipodystrophy 10.4 ADIPOQ LEP RETN
39 obesity-hypoventilation syndrome 10.4 ADIPOQ LEP RETN
40 inherited metabolic disorder 10.4 ADIPOQ INS LEP
41 multiple symmetrical lipomatosis 10.4 ADIPOQ LEP RETN
42 coronary artery aneurysm 10.4 ADIPOQ LEP RETN
43 diabetes mellitus, permanent neonatal 10.4 GCK INS KCNJ11
44 anovulation 10.4 INS LEP SHBG
45 neonatal diabetes mellitus 10.3 GCK INS KCNJ11
46 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.3 INS INSR
47 prediabetes syndrome 10.3 ADIPOQ INS LEP TCF7L2
48 arteries, anomalies of 10.3 ADIPOQ INS LEP
49 lipodystrophy, familial partial, type 2 10.3 INS LEP
50 hyperandrogenism 10.3 INS INSR SHBG

Graphical network of the top 20 diseases related to Gestational Diabetes:



Diseases related to Gestational Diabetes

Symptoms & Phenotypes for Gestational Diabetes

UMLS symptoms related to Gestational Diabetes:


morning sickness, pelvic pain, hyperemesis gravidarum

MGI Mouse Phenotypes related to Gestational Diabetes:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 INSR ADIPOR1 IRS1 ADRB3 GCK IRS2
2 adipose tissue MP:0005375 10.27 INSR ADIPOR1 IRS1 ADRB3 IRS2 INS
3 endocrine/exocrine gland MP:0005379 10.25 ADIPOQ INSR ADRB3 IRS1 GCK IRS2
4 growth/size/body region MP:0005378 10.24 INS ADIPOQ INSR ADIPOR1 ADRB3 IRS1
5 cardiovascular system MP:0005385 10.21 INS ADIPOQ INSR IRS1 RBP4 KCNJ11
6 liver/biliary system MP:0005370 10.03 ADIPOQ INSR ADIPOR1 IRS1 GCK IRS2
7 muscle MP:0005369 9.9 ADIPOQ INSR ADIPOR1 IRS1 IRS2 INS
8 renal/urinary system MP:0005367 9.5 INS ADIPOQ INSR GCK LEP TCF7L2
9 skeleton MP:0005390 9.28 INS ADIPOQ ADIPOR1 IRS1 RBP4 SLC29A1

Drugs & Therapeutics for Gestational Diabetes

PubMedHealth treatment related to Gestational Diabetes: 59

A change in diet is usually enough to make the levels return to normal. Women with gestational diabetes can get advice from their doctor. Special dietary counseling can be helpful too. Another way to lower your blood sugar levels is by getting more exercise. In some pregnant women the blood sugar levels stay high for so long that they have to inject insulin or, in rare cases, take medicine for diabetes.The doctor will offer to measure the woman’s blood sugar levels again after the baby is born. If her blood sugar levels have returned to normal, no more treatment is needed.

Drugs for Gestational Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
2
Insulin Aspart Approved Phase 4,Phase 3,Phase 2 116094-23-6 16132418
3
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
4
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 4091 14219
5
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2 10238-21-8 3488
6
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
7
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
8
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
9
Insulin Lispro Approved Phase 4,Phase 2 133107-64-9
10
Levonorgestrel Approved, Investigational Phase 4,Phase 2 797-63-7, 17489-40-6 13109
11
Copper Approved, Investigational Phase 4 7440-50-8 27099
12
Liraglutide Approved Phase 4,Phase 3 204656-20-2 44147092
13
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
14
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
16
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 58-05-9 143 6006
17
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 67-97-0 10883523 5280795 6221
18
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
19
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 1406-16-2
20
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
21 Analgesics Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Anti-Inflammatory Agents Phase 4
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4
25 Antineoplastic Agents, Phytogenic Phase 4
26 Antioxidants Phase 4,Phase 2,Phase 3
27 Antirheumatic Agents Phase 4
28 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
29 insulin Phase 4,Phase 2,Phase 3,Phase 1
30 Insulin, Globin Zinc Phase 4,Phase 2,Phase 3,Phase 1
31 Peripheral Nervous System Agents Phase 4
32 Platelet Aggregation Inhibitors Phase 4
33 Protective Agents Phase 4
34 Pharmaceutical Solutions Phase 4
35 Hematinics Phase 4,Phase 2,Phase 3
36 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
37 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
38 Vitamin B Complex Phase 4,Phase 2,Phase 3
39 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
40 Androgen Antagonists Phase 4
41 Androgens Phase 4
42 Contraceptive Agents Phase 4
43 Contraceptive Agents, Male Phase 4
44
Cyproterone Phase 4 2098-66-0 5284537
45 Cyproterone acetate, ethinyl estradiol drug combination Phase 4
46 Estradiol 17 beta-cypionate Phase 4
47 Estradiol 3-benzoate Phase 4
48 Estradiol valerate Phase 4 979-32-8
49 Hormone Antagonists Phase 4,Phase 3,Phase 2
50 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 469)

# Name Status NCT ID Phase Drugs
1 Can Resveratrol Improve Insulin Sensitivity and Preserve Beta Cell Function Following Gestational Diabetes? Unknown status NCT01997762 Phase 4
2 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
3 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
4 Prevention of Diabetes Mellitus Development in Women Who Had Already Experienced A Gestational Diabetes Unknown status NCT00265746 Phase 4 Metformin
5 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
6 Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women Unknown status NCT01511835 Phase 4 Folic Acid
7 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4 Diane-35 pretreatment;Diane-35 pretreatment
8 Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia Unknown status NCT01718340 Phase 4 Metformin
9 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
10 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
11 Antioxidants in Gestational Diabetes Completed NCT02355197 Phase 4 L-ascorbic acid
12 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4 metformin;insulin
13 Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women Completed NCT01675310 Phase 4 medical nutrition therapy + metformin
14 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
15 Humalog® Mix50/50(tm) as a Treatment for Gestational Diabetes Completed NCT01613807 Phase 4 Insulin LISPRO;Insulin, Long-Acting and Insulin LISPRO
16 Postpartum Glucose Tolerance With Levonorgesterel IUD Use in Women With Recent Gestational Diabetes Completed NCT01022645 Phase 4
17 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
18 Testing Ascensia Contour Glucometer for the Measurement of Blood Glucose Completed NCT00502359 Phase 4
19 Metformin Postpartum for GDM RCT for Reduced Weight Retention Completed NCT01280409 Phase 4 Metformin;Placebo
20 Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM Completed NCT01856907 Phase 4 Sitagliptin-Metformin;Metformin;Placebo pill
21 Resistance Exercise Training During Pregnancy: a Randomized Controlled Trial Completed NCT00813657 Phase 4
22 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
23 Preventing Recurrent Gestational Diabetes With Metformin Recruiting NCT02394158 Phase 4 Metformin;placebo
24 Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus Recruiting NCT03029702 Phase 4 Insulin;Glyburide;Metformin
25 Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn Recruiting NCT02508844 Phase 4
26 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4 Myo-inositol
27 The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Pregnancy-induced Diabetes Active, not recruiting NCT01795248 Phase 4 Liraglutide;Placebo
28 The Impact of Vitamin D Supplementation on Glucose Metabolism in Chinese Women With Former Gestational Diabetes Mellitus Enrolling by invitation NCT03138616 Phase 4 vitamin D
29 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Not yet recruiting NCT03078725 Phase 4 Glyburide;Metformin
30 Probiotics in Newly Recognized Type 1 Diabetes Not yet recruiting NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
31 ZIMBA: Clinical Trial in Paediatric Obesity Not yet recruiting NCT03283813 Phase 4 Placebos;Myoinositol
32 Exenatide Pregnancy Registry - Type 2 Diabetes in Pregnancy Terminated NCT00579150 Phase 4
33 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4 Glyburide;Insulin
34 Pilot Study of Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes Withdrawn NCT00572689 Phase 4 Exenatide
35 Glycemic Profile in Women With Gestational Diabetes Treated With Glyburide Withdrawn NCT01947699 Phase 4 Glyburide
36 Medico-GDM Trial - Metformine to Prevent Gestational Diabetes Mellitus Unknown status NCT02275845 Phase 3 Metformin
37 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3 Metformin;Insulin
38 Metformin for Prevention Gestational Diabetes in Pregnant Women With Polycystic Ovarian Syndrome Unknown status NCT02802215 Phase 2, Phase 3 metformin;placebo (folic acid )
39 Metformin for the Treatment of Diabetes in Pregnancy Unknown status NCT00414245 Phase 3 metformin
40 Modulation of the Intestinal Flora With the Probiotic VIVOMIXX™ in Pregnant Women at Risk of Metabolic Complications Unknown status NCT02768818 Phase 3
41 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3 Probiotics Lactobacillus Rhamnosus
42 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3 Magnesium citrate
43 Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus Completed NCT01087866 Phase 2, Phase 3 Metformin;Insulin
44 Gestational Diabetes: Insulin or Oral Hypoglycemic Agents? Completed NCT01215331 Phase 3 Insulin;Metformin, glyburide and insulin
45 Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus Completed NCT03320694 Phase 3 Metformin;Insulin
46 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Completed NCT01731431 Phase 3 Glyburide
47 A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS Completed NCT02080377 Phase 3 Glibenclamide;Insulin
48 Safety and Efficacy of Insulin Aspart vs. Regular Human Insulin in Gestational Diabetes Completed NCT00065130 Phase 3 human insulin;insulin NPH;insulin aspart
49 Efficacy of Behavioral Therapy and Exercise in Gestational Diabetes Mellitus (GDM) Completed NCT01506310 Phase 3
50 MAIN STUDY: Low Glycaemic Index (GI) Diet in the Management of GDM SUB-STUDY: The Breast Milk Sub-Study Completed NCT01589757 Phase 2, Phase 3

Search NIH Clinical Center for Gestational Diabetes

Cochrane evidence based reviews: diabetes, gestational

Genetic Tests for Gestational Diabetes

Genetic tests related to Gestational Diabetes:

# Genetic test Affiliating Genes
1 Diabetes Mellitus, Gestational 28

Anatomical Context for Gestational Diabetes

MalaCards organs/tissues related to Gestational Diabetes:

38
Testes, Ovary, Placenta, Breast, Liver, Endothelial, Thyroid

Publications for Gestational Diabetes

Articles related to Gestational Diabetes:

(show top 50) (show all 1281)
# Title Authors Year
1
Pregnancy Outcomes in Women with an Early Diagnosis of Gestational Diabetes Mellitus. ( 29427694 )
2018
2
The effects of synbiotic supplementation on insulin resistance/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: a randomized double blind placebo controlled clinical trial. ( 29432772 )
2018
3
Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus. ( 29398554 )
2018
4
Analysis of the correlation of gestational diabetes mellitus and peripheral ferritin with iron levels in early pregnancy. ( 29442476 )
2018
5
Barriers to a healthy lifestyle for three- to four-year-old children of Australian-born and overseas-born mothers with post-gestational diabetes: An Australian qualitative study. ( 29444583 )
2018
6
The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report. ( 29378555 )
2018
7
Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study. ( 29425094 )
2018
8
Type 2 Diabetes after Gestational diabetes: Can the progression be prevented? ( 29430798 )
2018
9
Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis. ( 29449829 )
2018
10
Circulating B-type natriuretic peptide in women with and without recent gestational diabetes: The impact of current glucose intolerance. ( 29112786 )
2018
11
The impact of a daily smartphone-based feedback system among women with gestational diabetes on compliance, glycemic control, satisfaction, and pregnancy outcome: a randomized controlled trial. ( 29425836 )
2018
12
Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies. ( 29405972 )
2018
13
Screening for gestational diabetes in low-risk women: effect of maternal age. ( 29425107 )
2018
14
Is Chemerin associated with gestational diabetes mellitus? An evidence-based clinical research from Chinese women. ( 29430984 )
2018
15
Therapies for gestational diabetes and their implications for maternal and offspring health: Evidence from human and animal studies. ( 29421161 )
2018
16
Elevated Medium Chain-Acylcarnitines are Associated with Gestational Diabetes, and Early Progression to Type-2 Diabetes, and Induce Pancreatic I^-Cell Dysfunction. ( 29436377 )
2018
17
Calcium Channel Blockers as Drug Repurposing Candidates for Gestational Diabetes: Mining large scale genomic and electronic health records data to repurpose medications. ( 29448118 )
2018
18
Metformin in women at high risk of gestational diabetes mellitus. ( 29422358 )
2018
19
Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study. ( 29337985 )
2018
20
Maternal gestational diabetes mellitus: is it associated with long-term pediatric ophthalmic morbidity of the offspring? ( 29429374 )
2018
21
Recent gestational diabetes was associated with mothers stopping predominant breastfeeding earlier in a multi-ethnic population. ( 29432660 )
2018
22
Effect of gestational diabetes and hypertensive disorders of pregnancy on postpartum cardiometabolic risk. ( 29444890 )
2018
23
Risk of glucose intolerance and gestational diabetes mellitus in relation to maternal habitual snoring during early pregnancy. ( 28926639 )
2017
24
Frequency of fetal macrosomia and the associated risk factors in pregnancies without gestational diabetes mellitus. ( 28451039 )
2017
25
Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial. ( 28938877 )
2017
26
Diagnostic protocol for gestational diabetes mellitus (GDM) (IADPSG/ADA, 2011): influence on the occurrence of GDM and mild gestational hyperglycemia (MGH) and on the perinatal outcomes. ( 28053673 )
2017
27
Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis. ( 28930827 )
2017
28
CCL2, CCL5, IL4 and IL15 Gene Polymorphisms in Women with Gestational Diabetes Mellitus. ( 27472286 )
2017
29
Prevention of neural tube defects and maternal gestational diabetes through the inositol supplementation: preliminary results. ( 28770950 )
2017
30
Associations of polymorphisms in the candidate genes for Alzheimer's disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance. ( 28316001 )
2017
31
Measurement and evaluation of fetal fat layer in the prediction of fetal macrosomia in pregnancies complicated by gestational diabetes. ( 28631075 )
2017
32
Is first-trimester HbA1c useful in the diagnosis of gestational diabetes? ( 28918341 )
2017
33
TCF7L2, CAPN10 polymorphisms are associated with gestational diabetes mellitus (GDM) risks: a meta-analysis. ( 28277135 )
2017
34
C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes. ( 28919328 )
2017
35
Risk of Type 2 Diabetes Mellitus following Gestational Diabetes Pregnancy in Women with Polycystic Ovary Syndrome. ( 29423416 )
2017
36
GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes. ( 28359772 )
2017
37
Macrosomia Rates in Women with Diet-Controlled Gestational Diabetes: A Retrospective Study. ( 28928985 )
2017
38
The effect of pre-pregnancy body mass index and excessive gestational weight gain on the risk of gestational diabetes in advanced maternal age. ( 28938562 )
2017
39
Gestational diabetes mellitus: The prevalence, associated factors and foeto-maternal outcome of women attending antenatal care. ( 29423124 )
2017
40
Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. ( 28081192 )
2017
41
Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. ( 28077460 )
2017
42
Response to Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723-725. ( 28931713 )
2017
43
Isolated polyhydramnios in the third trimester: is a gestational diabetes evaluation of value?() ( 28488900 )
2017
44
Impact of pre-gestational and gestational diabetes mellitus on the expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 in human term placenta. ( 27981520 )
2017
45
Potential protective effect of lactation against incidence of type 2 diabetes in women with previous gestational diabetes mellitus : A systematic review and meta-analysis. ( 28072911 )
2017
46
The Placental Microbiota Is Altered among Subjects with Gestational Diabetes Mellitus: A Pilot Study. ( 28932201 )
2017
47
The GCKR Gene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population. ( 27554451 )
2017
48
Specific metabolic characteristics of women with former gestational diabetes: the importance of adipose tissue. ( 28948819 )
2017
49
Pregnancies After the Diagnosis of Mild Gestational Diabetes Mellitus and Risk of Cardiometabolic Disorders. ( 28079773 )
2017
50
Polymorphism of the renalase gene in gestational diabetes mellitus. ( 27507673 )
2017

Variations for Gestational Diabetes

ClinVar genetic disease variations for Gestational Diabetes:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GCK NM_000162.3(GCK): c.544G> A (p.Val182Met) single nucleotide variant Pathogenic rs587780345 GRCh37 Chromosome 7, 44189603: 44189603
2 GCK NM_000162.3(GCK): c.616A> C (p.Thr206Pro) single nucleotide variant Pathogenic/Likely pathogenic rs587780346 GRCh37 Chromosome 7, 44189422: 44189422
3 GCK NM_000162.3(GCK): c.706G> A (p.Glu236Lys) single nucleotide variant Pathogenic rs587780347 GRCh37 Chromosome 7, 44187406: 44187406

Expression for Gestational Diabetes

Search GEO for disease gene expression data for Gestational Diabetes.

Pathways for Gestational Diabetes

Pathways related to Gestational Diabetes according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 GCK HKDC1 INS INSR IRS1 IRS2
2
Show member pathways
12.73 INS INSR IRS1 IRS2 SLC2A4
3
Show member pathways
12.66 ADRB3 INS INSR IRS1 IRS2
4
Show member pathways
12.63 ADIPOQ INS INSR IRS1 IRS2 LEP
5 12.5 ADIPOQ INS INSR IRS1 IRS2 NAMPT
6
Show member pathways
12.48 INS INSR IRS1 IRS2 SLC2A4
7
Show member pathways
12.43 GCK INS IRS1 IRS2 LEP
8
Show member pathways
12.39 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
9
Show member pathways
12.29 ADIPOQ ADIPOR1 INS KCNJ11
10
Show member pathways
12.2 INS INSR IRS1 IRS2 LEP SLC2A4
11
Show member pathways
12.11 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
12
Show member pathways
12.07 INS INSR IRS1 IRS2 SLC2A4
13
Show member pathways
11.95 INS INSR IRS1 IRS2 SLC2A4
14 11.88 ADIPOQ INS IRS1 IRS2 LEP NAMPT
15 11.85 ADIPOQ INS LEP SLC2A4
16 11.81 HKDC1 INS INSR
17 11.64 ADIPOQ ADIPOR1 IRS1 IRS2 LEP SLC2A4
18 11.61 INS INSR IRS1
19 11.56 ADRB3 INS INSR IRS1 IRS2
20 11.52 INS INSR IRS1 LEP
21 11.52 IRS1 IRS2 KCNJ11 LEP SLC2A4
22 11.43 GCK INS KCNJ11
23 11.41 INS INSR IRS1
24 11.34 INS INSR IRS1
25
Show member pathways
11.26 ADIPOQ GCK HKDC1 INS INSR IRS1
26 11.21 INS INSR SLC2A4
27
Show member pathways
10.93 INSR IRS1 SLC2A4
28 10.85 INS SLC2A4
29 10.78 ADIPOQ INSR IRS1 IRS2 LEP SLC2A4

GO Terms for Gestational Diabetes

Cellular components related to Gestational Diabetes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor complex GO:0005899 8.62 INSR IRS1

Biological processes related to Gestational Diabetes according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.93 ADRB3 GCK HKDC1 INS INSR SLC2A4
2 positive regulation of protein kinase B signaling GO:0051897 9.88 INS INSR IRS1 IRS2 LEP TCF7L2
3 response to ethanol GO:0045471 9.86 ADIPOQ LEP RBP4 SLC2A4
4 positive regulation of MAPK cascade GO:0043410 9.84 ADRB3 INS INSR LEP
5 female pregnancy GO:0007565 9.83 LEP NAMPT PAPPA
6 circadian rhythm GO:0007623 9.83 ADIPOQ LEP NAMPT
7 response to glucose GO:0009749 9.83 ADIPOQ IRS2 PTPRN TCF7L2
8 insulin receptor signaling pathway GO:0008286 9.83 INS INSR IRS1 IRS2 NAMPT
9 response to insulin GO:0032868 9.81 IRS1 LEP PTPRN RETN
10 cellular response to insulin stimulus GO:0032869 9.8 ADIPOQ GCK INSR IRS1 IRS2 SLC2A4
11 regulation of insulin secretion GO:0050796 9.79 GCK KCNJ11 LEP
12 cellular response to glucose stimulus GO:0071333 9.78 IRS2 KCNJ11 SLC29A1
13 positive regulation of insulin secretion GO:0032024 9.78 GCK IRS2 RBP4 TCF7L2
14 brown fat cell differentiation GO:0050873 9.72 ADIPOQ ADRB3 SLC2A4
15 positive regulation of cellular protein metabolic process GO:0032270 9.67 ADIPOQ INS
16 cellular glucose homeostasis GO:0001678 9.67 GCK HKDC1
17 fatty acid oxidation GO:0019395 9.67 ADIPOQ ADIPOR1
18 negative regulation of gluconeogenesis GO:0045721 9.67 ADIPOQ GCK INS
19 positive regulation of insulin receptor signaling pathway GO:0046628 9.67 ADIPOR1 INS IRS1 LEP
20 energy reserve metabolic process GO:0006112 9.66 ADRB3 LEP
21 glucose 6-phosphate metabolic process GO:0051156 9.65 GCK HKDC1
22 cellular response to leptin stimulus GO:0044320 9.65 GCK LEP
23 positive regulation of glucose import GO:0046326 9.65 ADIPOQ INS INSR IRS1 IRS2
24 positive regulation of fatty acid beta-oxidation GO:0032000 9.64 IRS1 IRS2
25 leptin-mediated signaling pathway GO:0033210 9.63 ADIPOR1 LEP
26 regulation of fatty acid biosynthetic process GO:0042304 9.63 ADIPOQ ADIPOR1
27 glucose metabolic process GO:0006006 9.63 ADIPOQ GCK INS IRS2 KCNJ11 LEP
28 positive regulation of glucose metabolic process GO:0010907 9.62 IRS1 IRS2
29 negative regulation of feeding behavior GO:2000252 9.61 INS RETN
30 adiponectin-activated signaling pathway GO:0033211 9.6 ADIPOQ ADIPOR1
31 positive regulation of respiratory burst GO:0060267 9.59 INS INSR
32 neuron projection maintenance GO:1990535 9.58 INS INSR
33 positive regulation of developmental growth GO:0048639 9.58 INSR LEP
34 positive regulation of glycogen biosynthetic process GO:0045725 9.35 GCK INS INSR IRS1 IRS2
35 glucose homeostasis GO:0042593 9.32 ADIPOQ ADIPOR1 GCK INS INSR IRS1
36 regulation of receptor activity GO:0010469 10.04 ADIPOQ INS LEP NAMPT RETN
37 positive regulation of cell proliferation GO:0008284 10.04 INS INSR IRS1 IRS2 LEP NAMPT

Molecular functions related to Gestational Diabetes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.56 ADIPOQ INS LEP RETN
2 glucose binding GO:0005536 9.46 GCK HKDC1
3 fructokinase activity GO:0008865 9.43 GCK HKDC1
4 mannokinase activity GO:0019158 9.4 GCK HKDC1
5 hexokinase activity GO:0004396 9.37 GCK HKDC1
6 insulin receptor binding GO:0005158 9.33 INS IRS1 IRS2
7 glucokinase activity GO:0004340 9.32 GCK HKDC1
8 phosphatidylinositol 3-kinase binding GO:0043548 9.13 INSR IRS1 IRS2
9 insulin-like growth factor receptor binding GO:0005159 8.8 INS INSR IRS1

Sources for Gestational Diabetes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....