Gestational Diabetes malady

Wikipedia: Gestational diabetes (or gestational diabetes mellitus, GDM) is a condition in which women without...⁴⁴ more...

MalaCards: Gestational Diabetes, also known as GDM, is related to insulin resistance and obesity. An important gene associated with Gestational Diabetes is LNPEP (leucyl/cystinyl aminopeptidase), and among its related pathways are Maturity onset diabetes of the young and Adipocytokines & Insulin Signaling. The drug chromium picolinate and the compounds glucose and sulfonylurea have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, skeletal muscle and adipocyte, and related mouse phenotypes are respiratory system and renal/urinary system.

OMIM: 125851

Aliases & Descriptions:

gestational diabetes 6 8 43 gdm 6 26 maternal gestational diabetes mellitus 6 diabetes mellitus, gestational 33

gestational diabetes mellitus 6 diabetes gestational 32 diabetes mellitus 43 diabetes 43

Diseases related to gestational diabetes by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1271)

id	Related Disease	Score	Top Affiliating Genes
1	insulin resistance	35.7	LEPR, UCP2, IRS1, INS, PPARGC1A, SOD1
2	obesity	35.4	PCSK1, UCP2, ENPP1, GHRL, ADRB3
3	neonatal diabetes mellitus	34.3	GCK, KCNJ11, INS, IGF1, TPO, PDX1
4	type 1 diabetes mellitus	33.9	RETN, GCK, GCG, RBP4, BGLAP, LEP
5	hepatitis	33.6	RBP4, SERPINA1, IL2RB, FAS, ALB, GLUD1
6	permanent neonatal diabetes mellitus	33.5	GCK, INS, ABCC8
7	diabetic angiopathy	33.3	SELE, INS, CAT, EDN1, AGER
8	autonomic neuropathy	33.2	GCG, INS, IGF1, ALB, PTPN3, PTPRN
9	diabetic macular edema	33.1	INS, IL6, CCL2, ICAM1, SST, EPO
10	diabetic ketoacidosis	32.7	VWF, BGLAP, INS, IL10, IL18, IL6
11	autoimmune thyroiditis	32.4	FAS, ICAM1, GHRL, TPO, CYP27B1, GAD2
12	celiac disease	32.4	MIF, IL6, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
13	transient neonatal diabetes mellitus	32.3	KCNJ11, INS, IGF1, TPO, ABCC8
14	lipoatrophic diabetes	32.2	RETN, LEP, IRS1, INS, PPARG, ADIPOQ
15	diabetic autonomic neuropathy	32.2	GCG, INS, IGF1, EPO, GAST
16	alcoholism	32.1	HTR2A, GLUD1, GHRL, HMGCR, TF, CP
17	diabetic foot ulcers	31.9	IGF1, CRP, PDGFB, TTR, TGFB1, SOD1
18	diabetic polyneuropathy	31.8	PARP1, APOB, CAT, TNF, NOS2, SOD1
19	morbid obesity	31.7	RETN, GCG, LEP, LEPR, INS, GHRL
20	gastroparesis	31.6	GCG, SERPINC1, INS, FAS, GHRL, GHSR
21	diabetic neuropathy	31.6	VWF, PARP1, LEP, UCP2, INS, IL1B
22	retinol binding protein	31.5	RETN, RBP4, NAMPT, LEP, LCN2, IRS1
23	polycystic ovary syndrome	31.2	LEP, IRS1, INS, INSR, IGFBP1, IGF2
24	rheumatoid arthritis	31.2	MBL2, HLA-DRB1, CRP, LTA
25	acanthosis nigricans	31.1	LEP, BAIAP2L1, INS, INSR, IGF1, SHBG
26	hypothyroidism	30.7	RETN, LEP, APOB, GHRL, TPO, SHBG
27	periodontitis	30.4	IL10, IL1B, IL6, IL8, CCL2, TNF
28	ischemic heart disease	30.1	RETN, SERPINE1, IL2RB, APOA1, APOB, HP
29	diabetes, type 2	30.0	GCG, SELE, KCNJ11, INS, IL18, ALB
30	autonomic dysfunction	29.9	SERPINE1, INS, INSR, IL6, APOA1, ALB
31	maturity-onset diabetes of the young	29.9	GCK, GCG, KCNJ11, IRS1, INS, IAPP
32	acute insulin response	29.9	GCG, KCNJ11, UCP2, INS, GLUD1, CRP
33	congestive heart failure	29.6	UTS2, APLN, HMGCR, TNFRSF11B, EDN1, ACE
34	glucose intolerance	29.6	GCG, APOB, GHRL, CP, GAST
35	vascular disease	29.5	RETN, VWF, SELE, SERPINC1, SERPINE1, NAMPT
36	hyperinsulinemic hypoglycemia	29.5	INS, IGF2, SST, ABCC8, GAST
37	addison's disease	29.4	PCSK1, BGLAP, MICA, INS, HLA-A, HLA-DQA1
38	fetal macrosomia	29.4	LEP, INS, INSR, IGF2, IGF1, GLS2
39	immunodeficiency	29.4	PARP1, MIF, INS, INSR, IL10, IL18
40	diabetes mellitus, noninsulin-dependent	29.3	IRS1, HNF4A, ABCC8, SLC2A4, NEUROD1
41	hepatitis c	29.3	SERPINA1, IL10, IL18, FAS, HP, HLA-A
42	hyperinsulinism	29.2	RETN, GCK, GCG, SELE, SERPINE1, KCNJ11
43	arthritis	29.2	SERPINA1, IL1B, IL6, IL8, TNF
44	pancreatic agenesis	29.1	GCK, KCNJ11, INS, PDX1, ABCC8
45	peripheral neuropathy	29.0	RETN, SELE, INS, IL10, IL6, APOA1
46	periodontal disease	29.0	SERPINB2, BGLAP, IL18, IL1B, IL6, IL8
47	peripheral vascular disease	28.8	VWF, SELE, SERPINE1, APOA1, APOB, ALB
48	arterial calcification	28.8	VWF, SELE, BGLAP, KCNJ11, LEP, FTO
49	prader-willi syndrome	28.7	RETN, GCG, LEP, LEPR, INS, IL18
50	multiple sclerosis	28.6	MICA, IL1B, ICAM1, HLA-A, HLA-DQA1, HLA-DQB1

Clinical features from OMIM: 125851

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chromium picolinate

MalaCards organs/tissues related to gestational diabetes:

²²

MGI Mouse Phenotypes related to gestational diabetes:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	CPB2, NEUROD1, HHEX, GAD2, PDGFB, PPARGC1A
2	renal/urinary system phenotype	MP:0005367	10.3	NEUROD1, INS, FOXC2, CDKN2B, FTO, MSTN
3	hematopoietic system phenotype	MP:0005397	10.1	PDGFB, HLA-DQB1, HLA-DQA1, IGF2, MIF, CDKN2B
4	endocrine/exocrine gland phenotype	MP:0005379	10.1	GGT1, GAD2, AFP, MED1, CDKAL1, CDKN2B
5	embryogenesis phenotype	MP:0005380	9.8	PRL, PPARD, APLNR, APLN, MED1, FOXC2
6	no phenotypic analysis	MP:0003012	9.8	GHSR, HMGA1, PTPN3, SST, NTS, PPARG
7	pigmentation phenotype	MP:0001186	9.6	CCL2, PDGFB, CP, GGT1, FAS, APOB
8	integument phenotype	MP:0010771	9.6	OXT, PDX1, PPARD, SREBF2, FAS, IL2RB
9	liver/biliary system phenotype	MP:0005370	9.5	GHR, FSTL3, MSTN, CEBPA, SERPINC1, GCK
10	limbs/digits/tail phenotype	MP:0005371	8.9	TNFRSF11B, LTA, HFE, PRG4, GGT1, GHR
11	skeleton phenotype	MP:0005390	8.8	HNF1A, GHSR, TNFRSF11B, PTPN3, CYP27B1, PPARG
12	immune system phenotype	MP:0005387	8.2	GGT1, GAST, GAD2, PPARD, PPARA, CYP27B1
13	nervous system phenotype	MP:0003631	8.2	VWF, HLA-DQB1, DDIT3, NTS, PDGFA, LTA
14	reproductive system phenotype	MP:0005389	8.1	GAD2, AFP, NOS2, PDGFA, PDGFB, AGT
15	digestive/alimentary phenotype	MP:0005381	8.0	INS, VWF, FOXC2, CDKN2A, MSTN, CEBPA
16	normal phenotype	MP:0002873	7.7	PTPN3, HLA-DQB1, HMGCR, GHRL, SST, PDX1
17	adipose tissue phenotype	MP:0005375	7.3	ADRB3, SLC2A4, TCF7L2, TGFB1, AGT, ACE
18	vision/eye phenotype	MP:0005391	7.0	PDGFB, NOS2, PLAT, PPARG, SREBF2, TNF
19	growth/size phenotype	MP:0005378	6.9	SST, FABP4, FASN, APOB, APLN, IL6
20	behavior/neurological phenotype	MP:0005386	6.9	CYB5R4, FASN, APOD, APLNR, APLN, IL6
21	muscle phenotype	MP:0005369	6.3	PPARA, FABP4, APLNR, APLN, IL6, IL18
22	mortality/aging	MP:0010768	6.2	LEP, VWF, PCSK1, GCK, KCNJ11, PARP1
23	tumorigenesis	MP:0002006	5.7	SERPINE1, LEP, LEPR, CEBPA, CDKN2B, CDKN2A
24	cellular phenotype	MP:0005384	4.3	EPO, INSR, LEP, PARP1, NAMPT, SELE
25	cardiovascular system phenotype	MP:0005385	4.2	EPO, HHEX, ADIPOQ, MED1, LNPEP, SERPINE1
26	homeostasis/metabolism phenotype	MP:0005376	1.6	GGT1, GAST, GAD2, AFP, EPO, HHEX

Articles related to gestational diabetes:

(show top 50)    (show all 330)

id	Title	Authors	Year	Affiliating Genes
1	Association of the Pro12Ala and C1431T variants of PP ARgamma and their haplotypes with susceptibility to gestational diabetes. (21795447)	Heude B.... Charles M.A.	2011	PPARG
2	Maternal and cord blood adiponectin multimeric forms in gestational diabetes mellitus: a prospective analysis. (21911780)	Ballesteros M.... Megia A.	2011	ADIPOQ
3	Plasma visfatin levels in pregnant women with normal glucose tolerance, gestational diabetes and pre-gestational diabetes mellitus. (20059442)	Coskun A.... Arikan D.C.	2010	NAMPT
4	Peroxisome proliferator-activated receptors are alter ed in pathologies of the human placenta: gestational diabetes mellitus, intraut erine growth restriction and preeclampsia. (20045185)	Holdsworth-Carson S.J.... Lappas M.	2010	PPARG, PPARA, PPARD
5	Declining beta-cell compensation for insulin resistan ce in Hispanic women with recent gestational diabetes mellitus: association wit h changes in weight, adiponectin, and C-reactive protein. (19933993)	Xiang A.H.... Buchanan T.A.	2010	ADIPOQ
6	In response to oxidative stress, the expression of in flammatory cytokines and antioxidant enzymes are impaired in placenta, but not adipose tissue, of women with gestational diabetes. (19833719)	Lappas M.... Permezel M.	2010	TNF
7	Single-nucleotide polymorphisms and genotype combina tions in calpain-10 gene of gestational diabetes mellitus (19565864)	Luo Y.P.... Zhao Y.Q.	2009	CAPN10
8	The change in sex hormone binding globulin and the in fluence by gestational diabetes mellitus in fetal period. (19557594)	Jin Z.... Li W.	2009	SHBG
9	First trimester serum neutrophil gelatinase-associate d lipocalin in gestational diabetes. (20002484)	D'Anna R.... di Benedetto A.	2009	LCN2
10	Serum trypsin inhibitory capacity in normal pregnancy and gestational diabetes mellitus. (19344972)	Yaghmaei M.... Ghavami S.	2009	SERPINA1
11	Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms. (18476984)	Ramos-Lopez E.... Badenhoop K.	2008	CYP27B1, CYP2R1
12	Correlation between the expression of gastrocolic om entum visfatin mRNA and gestational diabetes mellitus]. (19087564)	Liang Y.... Wang P.W.	2008	NAMPT
13	Metformin therapy for gestational diabetes mellitus: are we there yet? (18813215)	Feig D.S.	2008	INS
14	C-reactive protein and metabolic syndrome in women with previous gestational diabetes. (16770838)	Di Cianni G.... Del Prato S.	2007	CRP
15	Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes. (17305786)	Retnakaran R.... Hanley A.J.	2007	ADIPOQ
16	GCK and HNF1alpha mutations and polymorphisms in Polish women with gestational diabetes. (16963153)	Zurawek M.... Nowak J.	2007	GCK, HNF1A
17	Comparison of glyburide and insulin for the managemen t of gestational diabetics with markedly elevated oral glucose challenge test a nd fasting hyperglycemia. (17363911)	Ramos G.A.... Field D.R.	2007	INS
18	Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans. (17317761)	Watanabe R.M.... Buchanan T.A.	2007	TCF7L2
19	Prevalence of gestational diabetes mellitus and the effect of weight on measures of insulin secretion and insulin resistance in third-trimester pregnant rural women residing in the Central Region of Limpopo Province, South Africa. (17263763)	Mamabolo R.L.... Steyn N.P.	2007	INS
20	Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus. (17454170)	Altinova A.E.... Arslan M.	2007	TNF, ADIPOQ
21	C-reactive protein and features of metabolic syndrome in Brazilian women with previous gestational diabetes. (17449131)	Ferraz T.B.... Chacra A.R.	2007	CRP
22	Evaluation of adiponectin and TNFalpha genes expression in women with gestational diabetes. Preliminary results (17373119)	KuA_micki M.... GA^rska M.	2006	ADIPOQ
23	Plasminogen activator inhibitor 1 gene polymorphism and gestational diabetes mellitus. (16507937)	Leipold H.... Worda C.	2006	SERPINE1
24	Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women (17327028)	Tan Y.J.... Yang H.X.	2006	UTS2, UTS2D
25	Impaired circulating glucagon-like peptide-1 response to oral glucose in women with previous gestational diabetes. (15638870)	Forbes S.... Johnston D.G.	2005	GCG
26	Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. (16026366)	Sagen J.V.... Njolstad P.R.	2005	GCK, HNF4A, NEUROD1
27	Post-partum evaluation of amylin in lean patients with gestational diabetes mellitus. (15057546)	Kinalski M.... Kinalska I.	2004	IAPP
28	Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy. (14998944)	Glueck C.J.... Sherman A.	2004	INS
29	Different HLA-DR-DQ and MHC class I chain-related gene A (MICA) genotypes in autoimmune and nonautoimmune gestational diabetes in a Swedish population. (15603871)	Torn C.... Landin-Olsson M.	2004	HLA-A, MICA
30	Lack of relationship between beta3-adrenergic receptor gene polymorphism and gestational diabetes mellitus in a Taiwanese population. (15334374)	Tsai P.J.... Yu C.H.	2004	ADRB3
31	Factors predisposing to pre-eclampsia in women with gestational diabetes. (15614032)	Barden A.... Beilin L.J.	2004	CRP
32	Calpain-10 haplotype combination and association with gestational diabetes mellitus. (15172858)	Leipold H.... Worda C.	2004	CAPN10
33	Maternal plasma leptin levels and their relationship to insulin and glucose in pregnant women with gestational diabetes mellitus and gestational impaired glucose tolerance (12895305)	Liu Z.J.... Zhao X.F.	2003	LEP
34	Serum homocysteine levels are increased in women with gestational diabetes mellitus. (12800097)	Seghieri G.... Franconi F.	2003	ALB, INS
35	The risk of gestational diabetes is established sinc e fetal and postnatal period (12708352)	HernA!ndez-Valencia M.... ZA!rate A.	2003	PRL
36	Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. (12226133)	Tiikkainen M.... Yki-JAorvinen H.	2002	INS
37	The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes. (12626032)	Cseh K.... Winkler G.	2002	TNF, LEP, INS
38	Influence of maternal and fetal glucokinase mutations in gestational diabetes. (11483936)	Spyer G.... Macleod K.M.	2001	GCK
39	Optimization of insulin therapy in patients with gestational diabetes. (11419929)	Jovanovic L.	2000	INS
40	Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes. (10480612)	Friedman J.E.... Catalano P.	1999	INSR, IRS1
41	Gestational diabetes mellitus and subsequent development of overt diabetes mellitus. (9850811)	Damm P.	1998	INS
42	Elevated lipoprotein lipids and gestational hormones in women with diet-treated gestational diabetes mellitus compared to healthy pregnant controls. (9442808)	Couch S.C.... Lammi-Keefe C.J.	1998	PRL
43	Gestational diabetes mellitus is associated with an increase in the total concentration of amylin molecules. (9571363)	Wareham N.J.... Rahilly S.O.	1998	IAPP
44	Measurement of glucose metabolism and insulin secretion during normal pregnancy and pregnancy complicated by gestational diabetes. (8858221)	Bowes S.B.... Lowy C.	1996	INS
45	Gestational diabetes complicated by severe hypertrigl yceridemia and acute pancreatitis. (8779609)	Bar-David J.... Maislos M.	1996	INS
46	Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy. (7565999)	de Veciana M.... Evans A.T.	1995	INS
47	Breast-feeding in reducing regular insulin requireme nt in postpartum for insulin dependent diabetes mellitus and gestational diabet es mellitus (8082426)	Yang J.Q.... Gai M.Y.	1994	INS
48	Insulin binding to trophoblast plasma membranes and placental glycogen content in well-controlled gestational diabetic women treated with diet or insulin, in well-controlled overt diabetic patients and in healthy control subjects. (1541381)	Desoye G.... Weiss P.A.	1992	INS
49	Percentage of carbohydrate and glycemic response to b reakfast, lunch, and dinner in women with gestational diabetes. (1748252)	Peterson C.M.... Jovanovic-Peterson L.	1991	INS
50	Increased risk for gestational diabetes mellitus associated with insulin receptor and insulin-like growth factor II restriction fragment length polymorphisms. (2574127)	Ober C.... Dooley S.	1989	INSR, IGF2

Genes related to gestational diabetes according to GeneCards:

(show top 50)    (show all 158)

id	Symbol	Description	Score	GeneCards Section Context
1	LNPEP	leucyl/cystinyl aminopeptidase	11.0	Publications
2	ATHS	atherosclerosis susceptibility (lipoprotein associated)	11.0	Publications
3	HLA-DRB2	major histocompatibility complex, class II, DR beta 2 (pseudogene)	11.0	Publications
4	HLA-DRB9	major histocompatibility complex, class II, DR beta 9 (pseudogene)	11.0	Publications
5	NAMPT	nicotinamide phosphoribosyltransferase	11.0	Publications
6	GCK	glucokinase (hexokinase 4)	11.0	Publications
7	IGKV2D-29	immunoglobulin kappa variable 2D-29	11.0	Publications
8	CYP2R1	cytochrome P450, family 2, subfamily R, polypeptide 1	11.0	Publications
9	RBP4	retinol binding protein 4, plasma	11.0	Publications
10	FSTL3	follistatin-like 3 (secreted glycoprotein)	11.0	Publications
11	ZNRD1	zinc ribbon domain containing 1	11.0
12	GLS2	glutaminase 2 (liver, mitochondrial)	11.0
13	KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	11.0	Publications
14	CAPN10	calpain 10	11.0	Publications
15	SLC29A1	solute carrier family 29 (nucleoside transporters), member 1	11.0	Publications
16	GGCT	gamma-glutamylcyclotransferase	11.0
17	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	11.0	Publications
18	HHEX	hematopoietically expressed homeobox	11.0	Publications
19	HLA-DRB6	major histocompatibility complex, class II, DR beta 6 (pseudogene)	11.0	Publications
20	SERPINA12	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	11.0	Publications
21	GIP	gastric inhibitory polypeptide	11.0	Publications
22	PTPRN	protein tyrosine phosphatase, receptor type, N	11.0	Publications
23	NUCB2	nucleobindin 2	11.0	Publications
24	PRG4	proteoglycan 4	11.0
25	INS	insulin	11.0	Publications
26	ORM1	orosomucoid 1	11.0	Publications
27	IAPP	islet amyloid polypeptide	11.0	Publications
28	APLNR	apelin receptor	11.0	Publications
29	APLN	apelin	11.0	Publications
30	HNF1A	HNF1 homeobox A	11.0	Publications
31	CPB2	carboxypeptidase B2 (plasma)	11.0	Publications
32	GTF3A	general transcription factor IIIA	11.0	Publications
33	FABP4	fatty acid binding protein 4, adipocyte	11.0	Publications
34	MSTN	myostatin	11.0	Publications
35	LIPG	lipase, endothelial	11.0	Publications
36	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
37	NEUROD1	neuronal differentiation 1	11.0	Publications
38	AHSG	alpha-2-HS-glycoprotein	11.0	Publications
39	MTNR1B	melatonin receptor 1B	11.0	Publications
40	RETN	resistin	11.0	Publications
41	CYB5R4	cytochrome b5 reductase 4	11.0	Publications
42	ADRB3	adrenoceptor beta 3	11.0	Publications
43	UTS2	urotensin 2	11.0	Publications
44	TCF20	transcription factor 20 (AR1)	11.0	Publications
45	APOD	apolipoprotein D	11.0	Publications
46	UTS2D	urotensin 2 domain containing	11.0	Publications
47	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
48	ADIPOR1	adiponectin receptor 1	11.0	Publications
49	BAIAP2L1	BAI1-associated protein 2-like 1	11.0	Publications
50	INSR	insulin receptor	11.0	Publications

Pathways related to gestational diabetes according to GeneDecks:

(show top 50)    (show all 115)

id	Pathway	Score	Top Affiliating Genes
1	Maturity onset diabetes of the young20	11.0	PDX1, HNF4A, HHEX, GCK, HNF1A, NEUROD1
2	Adipocytokines & Insulin Signaling37	10.9	ADIPOQ, SLC2A4, INSR, INS, IRS1, LEP
3	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	10.9	INSR, HNF1A, HNF4A, INS, ABCC8, PDX1
4	Type II diabetes mellitus20	10.8	PDX1, SLC2A4, ABCC8, ADIPOQ, KCNJ11, IRS1
5	Graft-versus-host disease20	10.7	HLA-DRB5, HLA-DRB3, HLA-DQA1, HLA-A
6	Glucose / Energy Metabolism3	10.6	HNF4A, SLC2A4, NEUROD1, WFS1, ADIPOQ, GAD2
7	Development Leptin signaling via PI3K-dependent pathway10	10.5	SLC2A4, ABCC8, IRS1, CEBPA, KCNJ11, LEPR
8	Development_Leptin signaling via PI3K-dependent pathway41	10.4	LEP, IRS1, LEPR, CEBPA, KCNJ11, PIK3R1
9	Adipocytokine signaling pathway20	10.2	PPARGC1A, ADIPOR1, ADIPOQ, LEP, SLC2A4, NFKB1
10	Selected targets of HNF110	10.1	APOA1, PDX1, ALB, IAPP, CRP, IGFBP1
11	Selected targets of C/EBPalpha10	10.0	ADIPOQ, SERPINC1, RETN, CEBPA, FABP4, ALB
12	Transcription PPAR Pathway10	9.9	PIK3R1, MED1, PPARG, PPARA, PPARD, PDGFRB
13	THC Differentiation Pathway36	9.8	IL10, TNF, HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1
14	Akt Signaling36	9.6	PDGFRB, IL2RB, PDGFA, CCL2, IL6, IL18
15	Allograft rejection20	9.4	TNF, HLA-DRB5, HLA-DRB3, FAS, IL10, HLA-A
16	JNK Pathway36	9.4	UTS2, PDGFRB, IL6, TGFB1, TCF20, IL2RB
17	Autoimmune thyroid disease20	9.4	IL10, HLA-A, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB5
18	Selected targets of GCR-alpha10	9.4	APLNR, INSR, INS, LEP, GHR, IL1B
19	Type I diabetes mellitus20	9.3	TNF, PTPRN, LTA, GAD2, HLA-DRB5, HLA-DRB3
20	PPAR Pathway36	9.3	TNF, PPARG, PIK3R1, IL6, IGF2, IGF1
21	Asthma20	9.3	IL10, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB5
22	Molecular Mechanisms of Cancer36	9.2	UTS2, CDKN2B, CDKN2A, INSR, IL6, IGF2
23	PGC1Alpha Pathway36	9.2	INSR, PPARA, SLC2A4, IL8, IL1B, IL18
24	Pathways in cancer20	9.2	CDKN2B, FAS, PPARD, NOS2, PDGFA, CEBPA
25	Immune response MIF-mediated glucocorticoid regulation10	9.1	MIF, IL8, IL6, ICAM1, NFKB1, NOS2
26	Immune response_MIF-mediated glucocorticoid regulation41	9.1	MIF, NFKB1, NOS2, ICAM1, TNF, IL8
27	African trypanosomiasis20	8.9	SELE, IL10, IL18, TNF, IL1B, APOA1
28	NFAT in Immune Response36	8.6	PDGFB, NFKB1, HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1
29	Apoptotic Pathways in Synovial Fibroblasts36	8.6	PDGFA, PIK3R1, UTS2, IL6, IGF2, IGF1
30	Immune response IL-1 signaling pathway10	8.6	EDN1, CP, NFKB1, IL1B, SERPINE1, NOS2
31	Immune response_IL-1 signaling pathway41	8.6	CP, EDN1, NFKB1, NOS2, TNF, IL6
32	Intestinal immune network for IgA production20	8.5	HLA-DRB3, HLA-DQB1, HLA-DRB1, HLA-DQA1, IL6, IL10
33	Leishmaniasis20	8.3	NFKB1, TGFB1, HLA-DRB3, HLA-DRB5, HLA-DRB1, HLA-DQA1
34	Toxoplasmosis20	8.2	PIK3R1, NFKB1, HLA-DRB5, IL10, HLA-DQA1, HLA-DRB3
35	ERK Signaling36	8.2	INSR, IL18, CAPN10, UTS2, IL6, PRG4
36	MAPK Signaling36	8.1	UTS2, PDGFB, PRG4, PDGFRB, LTA, TGFB1
37	Influenza A20	8.0	IL6, PIK3R1, HLA-DQB1, HLA-DRB1, HLA-DRB3, NFKB1
38	Tuberculosis20	8.0	TNF, TGFB1, NFKB1, NOS2, HLA-DRB5, IL10
39	Rheumatoid arthritis20	7.8	CCL2, IL6, HLA-DQB1, IL1B, IL8, ICAM1
40	Malaria20	7.8	ICAM1, SELE, IL10, IL18, IL1B, IL6
41	Rho Family GTPases36	7.1	PDGFB, LTA, PDGFA, NFKB1, IGF1, IGF2
42	PAK Pathway36	7.0	TNF, IGF2, PDGFRB, LTA, PDGFB, TGFB1
43	p38 Signaling36	7.0	INSR, CEBPA, UTS2, IL10, TNF, IL18
44	Tec Kinases Signaling36	7.0	TGFB1, PDGFA, PDGFRB, PDGFB, NFKB1, IGF1
45	TGF-Beta Pathway36	6.9	IL8, IL6, IL18, UTS2, TGFB1, IL10
46	MAPK Family Pathway36	6.9	NFKB1, PDGFA, LTA, TGFB1, UTS2, PIK3R1
47	Antioxidant Action of Vitamin-C36	6.8	IGF1, NFKB1, PDGFB, TNF, PDGFA, IL6
48	Chagas disease (American trypanosomiasis)20	6.7	IL10, NOS2, NFKB1, CCL2, FAS, IL8
49	Cytokine-cytokine receptor interaction20	6.5	LEP, LEPR, IL10, IL18, IL1B, IL2RB
50	JAK-STAT Pathway36	6.3	UTS2, INSR, PRL, IGF1, PIK3R1, IL10

Compounds related to gestational diabetes according to GeneDecks:

(show top 50)    (show all 496)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.9	PCSK1, GCG, SERPINA12, KCNJ11, BAIAP2L1, MTNR1B
2	sulfonylurea32	10.6	GCK, GCG, KCNJ11, IRS1, IAPP, GLUD1
3	c-peptide32	10.3	RETN, PCSK1, GCK, GCG, KCNJ11, LEP
4	glycogen32 18	11.3	PIK3R1, RETN, GCK, GCG, LNPEP, LEPR
5	sodium nitroprusside32	10.2	VWF, IRS1, CAT, SST, ACP1, TF
6	isoproterenol32 9 9	12.2	PIK3R1, GCG, UCP2, INSR, IAPP, PTPN3
7	thiazolidinedione32	9.8	RETN, SERPINE1, LEP, UCP2, IRS1, INS
8	pravastatin32 34 9 18 9	13.7	SELE, SERPINE1, GTF3A, IL18, IL6, APOA1
9	estradiol32 9 18 9	12.7	SERPINE1, LEPR, MED1, IL18, FASN, IGFBP1
10	sterol32	9.5	PIK3R1, RETN, GCK, UCP2, CEBPA, IRS1
11	calcium32 9 18 9	12.4	RETN, VWF, PCSK1, GCK, RBP4, SERPINB2
12	acetylcholine32 9 18 9	12.4	VWF, GCG, UTS2, LEP, INSR, IL18
13	triiodothyronine32	9.4	RBP4, LEP, LEPR, UCP2, FASN, IGFBP1
14	acipimox32	9.4	GCG, LEP, INS, APOA1, APOB, IGF1
15	tibolone32	9.4	SELE, SERPINC1, SERPINE1, BGLAP, LEP, APOA1
16	nash32	9.3	RETN, LEP, LEPR, UCP2, INS, TNF
17	chloramphenicol32 9 9	11.3	SELE, SERPINC1, SERPINE1, CDKN2A, INSR, APOB
18	ascorbic acid32 18	10.3	RBP4, SERPINB2, BGLAP, FAS, IGF2, TPO
19	corticosterone32 18	10.3	GCG, BGLAP, LEPR, MIF, IL1B, CCL2
20	pge232	9.2	SELE, SERPINB2, LNPEP, APOA1, HP, TNFRSF11B
21	uric acid32 18	10.2	RETN, RBP4, SERPINE1, LEP, INS, APOA1
22	calcitriol32 42 9 18 9	13.1	BGLAP, FASN, IGFBP1, IAPP, ALB, GHR
23	adenylate32	9.1	VWF, PCSK1, GCK, GCG, RBP4, SELE
24	sb 20358032 42	10.0	GCG, SELE, BGLAP, PARP1, IRS1, INSR
25	heparin32 9 18 9	12.0	VWF, GCG, SERPINB2, SERPINA1, SERPINE1, BGLAP
26	homocysteine32 18	9.9	RETN, VWF, SELE, SERPINC1, SERPINE1, MIF
27	octreotide32 42 9 9	11.8	GCG, UTS2, INS, INSR, IGFBP1, IGF2
28	oxygen32 18	9.8	GCK, RBP4, SERPINA1, UTS2, LIPG, PARP1
29	ibmx32	8.5	PCSK1, GCG, IRS1, INS, INSR, IL1B
30	metformin32 34 9 9	11.3	RETN, VWF, GCK, GCG, SERPINE1, NAMPT
31	8-isoprostane32	8.1	RETN, SELE, SERPINE1, LEP, INS, IL10
32	arginine32	8.1	VWF, PCSK1, GCK, GCG, SERPINC1, LNPEP
33	norepinephrine32 9 18 9	11.0	RETN, VWF, GCG, SELE, UTS2, LEP
34	atorvastatin32 34 9 18 9	12.0	RETN, VWF, SELE, SERPINE1, IL10, IL18
35	ciglitazone32	7.6	SERPINE1, PARP1, IL1B, IL6, IL8, CCL2
36	paraffin32	7.5	VWF, SERPINB2, SERPINA1, BGLAP, LEP, CDKN2A
37	simvastatin32 34 42 9 18 9	12.5	VWF, RBP4, SELE, SERPINE1, BGLAP, IL10
38	ribonucleic acid32	7.5	PCSK1, RBP4, SERPINB2, NAMPT, LEPR, UCP2
39	aspirin32 34 18	9.4	VWF, SELE, SERPINC1, SERPINE1, IRS1, IL18
40	estrogen32	7.4	PIK3R1, RETN, VWF, PCSK1, GCG, RBP4
41	lipid32	7.0	PIK3R1, RETN, PCSK1, GCK, GCG, RBP4
42	cyclosporin a32 42	8.0	VWF, SERPINB2, BGLAP, LEP, IL10, IL18
43	nitric oxide32 9 18 9	9.8	RETN, GCK, SELE, SERPINB2, SERPINA1, UTS2
44	cholesterol32 9 18 9	9.4	PIK3R1, RETN, VWF, GCK, RBP4, SELE
45	indomethacin32 9 9	8.1	GCG, UTS2, LEP, IL18, IL1B, IL6
46	histamine32 18	6.8	VWF, GCG, SELE, BGLAP, IL10, IL18
47	genistein32 9 18 9	8.7	PIK3R1, GCG, SELE, SERPINE1, PARP1, BAIAP2L1
48	retinoic acid32 42 18	7.4	VWF, GCK, RBP4, SERPINB2, SERPINE1, BGLAP
49	actinomycin d32	4.9	RETN, SELE, SERPINB2, SERPINE1, PARP1, CDKN2A
50	dexamethasone32 42 34 9 9	7.7	PIK3R1, RETN, VWF, GCK, RBP4, SERPINC1

Cellular components related to gestational diabetes according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	clathrin-coated endocytic vesicle membrane	GO:030669	10.1	HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, APOB
2	transport vesicle membrane	GO:030658	10.1	SLC30A8, HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
3	ER to Golgi transport vesicle membrane	GO:012507	10.1	SREBF2, SREBF1, HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1
4	MHC class II protein complex	GO:042613	10.1	HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
5	trans-Golgi network membrane	GO:032588	10.1	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB5
6	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.0	HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-A
7	secretory granule	GO:030141	9.7	SLC30A8, OXT, TF, PLAT, GHRL, GIP
8	integral to plasma membrane	GO:005887	9.3	HLA-DRB3, TPO, TNF, PTPRN, PDGFRB, HFE
9	external side of plasma membrane	GO:009897	8.9	SLC2A4, ACE, TNF, HLA-DRB5, HLA-DRB3, HLA-DRB1
10	cell surface	GO:009986	8.7	TNF, PLAT, PDGFA, PDGFB, TGFB1, TPO
11	platelet alpha granule lumen	GO:031093	8.6	TGFB1, PDGFB, PDGFA, ALB, IGF1, SERPINE1
12	plasma membrane	GO:005886	7.4	ABCC8, PDGFRB, TNF, TPO, HLA-DRB5, HLA-DRB3
13	extracellular region	GO:005576	4.1	GAST, RETN, INS, IL18, IL1B, IL6
14	extracellular space	GO:005615	3.8	PCSK1, INS, IL10, IL18, IL1B, IL6

Biological processes related to gestational diabetes according to GeneDecks:

(show top 50)    (show all 103)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of insulin secretion	GO:032024	10.9	SLC30A8, GLUD1, TCF7L2, GCK, RBP4, GHRL
2	glucose homeostasis	GO:042593	10.8	INSR, ADIPOQ, HNF1A, WFS1, INS, IRS1
3	endocrine pancreas development	GO:031018	10.8	IL6, GCK, INS, NEUROD1, PDX1, GIP
4	energy reserve metabolic process	GO:006112	10.8	ADRB3, ABCC8, GIP, FASN, INS, LEPR
5	brown fat cell differentiation	GO:050873	10.7	ADRB3, ADIPOQ, PPARG, PPARGC1A, FABP4, CEBPA
6	glucose metabolic process	GO:006006	10.7	LEP, INS, APOD, IGF2, GHRL, TNF
7	acute-phase response	GO:006953	10.5	AHSG, CRP, MBL2, IL6, INS, CEBPA
8	cellular response to insulin stimulus	GO:032869	10.4	ADIPOQ, GCK, SLC2A4, AHSG, PPARG, GHSR
9	cholesterol metabolic process	GO:008203	10.4	APOB, CEBPA, LEPR, LEP, SREBF1, SREBF2
10	positive regulation of glucose import	GO:046326	10.4	PIK3R1, IGF1, INS, CAPN10, INSR, ADIPOQ
11	positive regulation of glycogen biosynthetic process	GO:045725	10.3	IGF2, IGF1, GCK, IRS1, INS, INSR
12	insulin secretion	GO:030073	10.2	LEP, HNF1A, CYB5R4, PDX1, SLC30A8, NEUROD1
13	response to nutrient	GO:007584	10.2	PPARG, ADIPOQ, DDIT3, SST, TNFRSF11B, HMGCR
14	response to ethanol	GO:045471	10.2	CCL2, ADIPOQ, SOD1, SLC2A4, ICAM1, RBP4
15	regulation of insulin secretion	GO:050796	10.2	TNF, IL1B, HNF4A, ABCC8, NOS2, GIP
16	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.1	IGF1, INS, CAT, PPARD, PDGFA, PDGFB
17	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.1	HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1
18	response to glucose stimulus	GO:009749	10.1	PTPRN, SLC30A8, ADIPOQ, NEUROD1, HNF4A, TGFB1
19	positive regulation of MAPK cascade	GO:043410	10.1	LEP, INS, PDGFA, ADRB3, AGT, PDGFB
20	response to testosterone stimulus	GO:033574	10.1	EPO, EDN1, INSR, MSTN, BGLAP, UTS2
21	response to estrogen stimulus	GO:043627	9.9	PTPRN, MSTN, GHRL, FAS, PPARG, EPO
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	IGF1, GHR, PDGFB, AGT, ADIPOQ, IL6
23	response to heat	GO:009408	9.7	SOD1, CPB2, MICA, CCL2, MSTN, IL1B
24	lipid metabolic process	GO:006629	9.7	APOB, SREBF2, SREBF1, HNF4A, ALB, FABP4
25	response to activity	GO:014823	9.6	CCL2, TNF, BGLAP, INSR, IL10, OXT
26	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	EDN1, ICAM1, TNF, IL1B, INSR, INS
27	positive regulation of mitosis	GO:045840	9.4	INS, INSR, EDN1, PDGFRB, PDGFB, TNF
28	negative regulation of apoptotic process	GO:043066	9.4	NEUROD1, TNF, GHRL, CAT, EPO, IL6
29	organ regeneration	GO:031100	9.4	AHSG, PPARG, CEBPA, CCL2, MED1, AFP
30	cell-cell signaling	GO:007267	9.3	LNPEP, NAMPT, PCSK1, IAPP, IL10, IL18
31	positive regulation of MAP kinase activity	GO:043406	9.3	HTR2A, PDGFA, PDGFB, PDGFRB, EDN1, TGFB1
32	positive regulation of protein kinase B signaling cascade	GO:051897	9.2	IGF1, IGF2, INSR, TNF, PDGFA, INS
33	small molecule metabolic process	GO:044281	9.2	APOA1, PCSK1, GCK, NAMPT, KCNJ11, UCP2
34	cytokine-mediated signaling pathway	GO:019221	9.1	HLA-DRB3, CCL2, PTPRN, HLA-DRB5, HLA-DQB1, ICAM1
35	cellular response to organic cyclic compound	GO:071407	9.1	IL18, IL1B, CCL2, TNF, PPARG, CEBPA
36	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	AGER, INS, TGFB1, AGT, IL1B, IL6
37	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.6	TCF7L2, SREBF2, PPARD, PPARG, PPARA, NFKB1
38	response to glucocorticoid stimulus	GO:051384	8.5	MSTN, CEBPA, BGLAP, SERPINE1, GHR, INSR
39	positive regulation of cell proliferation	GO:008284	8.5	IL6, INSR, INS, IRS1, LEP, NAMPT
40	platelet degranulation	GO:002576	8.4	SERPINE1, VWF, SERPINA1, APOA1, IGF1, ALB
41	aging	GO:007568	8.3	DDIT3, HMGCR, CCL2, APOD, IL1B, FAS
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	IL6, IGF1, HNF1A, HNF4A, TNF, IL1B
43	anti-apoptosis	GO:006916	8.1	IL10, SERPINB2, IL1B, FAS, CCL2, IGF1
44	platelet activation	GO:030168	8.0	IL6, SERPINE1, SERPINA1, VWF, PIK3R1, APOA1
45	response to drug	GO:042493	7.9	TNFRSF11B, EDN1, LTA, PDGFB, PPARG, SST
46	response to hypoxia	GO:001666	7.7	UTS2, LEP, IL18, SERPINA1, IL1B, CRP
47	inflammatory response	GO:006954	7.6	SELE, MIF, IL10, IL6, ORM1, TGFB1
48	negative regulation of cell proliferation	GO:008285	7.6	TNF, CYP27B1, SST, PDX1, AGT, TGFB1
49	blood coagulation	GO:007596	7.6	PLAT, PDGFA, SERPINC1, PIK3R1, VWF, PDGFB
50	positive regulation of transcription, DNA-dependent	GO:045893	7.4	HNF4A, HMGA1, TNF, PPARGC1A, PPARG, PPARA

Molecular functions related to gestational diabetes according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin binding	GO:043559	10.5	IDE, INSR, PCSK1, PIK3R1
2	transcription regulatory region DNA binding	GO:044212	10.3	HHEX, TCF7L2, NFKB1, PPARG, TNF, HNF4A
3	protease binding	GO:002020	10.1	TNF, INS, SERPINE1, SERPINA1, SERPINC1
4	insulin-like growth factor receptor binding	GO:005159	10.0	IGF1, IGF2, INSR, INS, IRS1, PIK3R1
5	MHC class II receptor activity	GO:032395	10.0	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
6	insulin receptor binding	GO:005158	9.9	IGF1, IGF2, ENPP1, INS, IRS1, PIK3R1
7	receptor binding	GO:005102	9.8	CAT, HNF4A, HLA-A, NOS2, PDGFRB, LTA
8	transcription factor binding	GO:008134	9.7	HHEX, NEUROD1, TCF7L2, PPARGC1A, DDIT3, HMGA1
9	eukaryotic cell surface binding	GO:043499	9.4	EPO, ADIPOQ, TGFB1, PDGFB, PDGFA, MBL2
10	hormone activity	GO:005179	9.3	RETN, SST, EDN1, AGT, TTR, PRL
11	cytokine activity	GO:005125	9.1	ADIPOQ, EDN1, LTA, TNFRSF11B, TNF, IL6
12	drug binding	GO:008144	9.0	PPARD, PPARA, PPARG, ALB, HTR2A, ACE
13	protein homodimerization activity	GO:042803	8.9	PDGFA, PDGFB, SHBG, TGFB1, SOD1, SLC30A8
14	growth factor activity	GO:008083	8.1	TGFB1, AGT, PDGFB, PDGFA, IGF1, IGF2
15	protein binding	GO:005515	3.6	PPARG, PPARA, CRP, PLAT, NOS2, NFKB1