Gestational Diabetes malady

Wikipedia: Gestational diabetes (or gestational diabetes mellitus, GDM) is a condition in which women without...⁴⁴ more...

MalaCards: Gestational Diabetes, also known as GDM, is related to insulin resistance and obesity. An important gene associated with Gestational Diabetes is LNPEP (leucyl/cystinyl aminopeptidase), and among its related pathways are Maturity onset diabetes of the young and Adipocytokines & Insulin Signaling. The drug chromium picolinate and the compounds sulfonylurea and pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, skeletal muscle and adipocyte, and related mouse phenotypes are respiratory system and renal/urinary system.

OMIM: 125851

Aliases & Descriptions:

gestational diabetes 6 8 43 gdm 6 26 maternal gestational diabetes mellitus 6 diabetes mellitus, gestational 33

gestational diabetes mellitus 6 diabetes gestational 32 diabetes mellitus 43 diabetes 43

Diseases related to gestational diabetes by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1271)

id	Related Disease	Score	Top Affiliating Genes
1	insulin resistance	35.7	LEPR, UCP2, IRS1, INS, PPARGC1A, SOD1
2	obesity	35.4	PCSK1, UCP2, ENPP1, GHRL, ADRB3
3	neonatal diabetes mellitus	34.3	GCK, KCNJ11, INS, IGF1, TPO, PDX1
4	type 1 diabetes mellitus	33.9	RETN, GCK, GCG, RBP4, BGLAP, LEP
5	hepatitis	33.6	RBP4, SERPINA1, IL2RB, FAS, ALB, GLUD1
6	permanent neonatal diabetes mellitus	33.5	GCK, INS, ABCC8
7	diabetic angiopathy	33.3	SELE, INS, CAT, EDN1, AGER
8	autonomic neuropathy	33.2	GCG, INS, IGF1, ALB, PTPN3, PTPRN
9	diabetic macular edema	33.1	INS, IL6, CCL2, ICAM1, SST, EPO
10	diabetic ketoacidosis	32.7	VWF, BGLAP, INS, IL10, IL18, IL6
11	autoimmune thyroiditis	32.4	FAS, ICAM1, GHRL, TPO, CYP27B1, GAD2
12	celiac disease	32.4	MIF, IL6, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
13	transient neonatal diabetes mellitus	32.3	KCNJ11, INS, IGF1, TPO, ABCC8
14	lipoatrophic diabetes	32.2	RETN, LEP, IRS1, INS, PPARG, ADIPOQ
15	diabetic autonomic neuropathy	32.2	GCG, INS, IGF1, EPO, GAST
16	alcoholism	32.1	HTR2A, GLUD1, GHRL, HMGCR, TF, CP
17	diabetic foot ulcers	31.9	IGF1, CRP, PDGFB, TTR, TGFB1, SOD1
18	diabetic polyneuropathy	31.8	PARP1, APOB, CAT, TNF, NOS2, SOD1
19	morbid obesity	31.7	RETN, GCG, LEP, LEPR, INS, GHRL
20	gastroparesis	31.6	GCG, SERPINC1, INS, FAS, GHRL, GHSR
21	diabetic neuropathy	31.6	VWF, PARP1, LEP, UCP2, INS, IL1B
22	retinol binding protein	31.5	RETN, RBP4, NAMPT, LEP, LCN2, IRS1
23	polycystic ovary syndrome	31.2	LEP, IRS1, INS, INSR, IGFBP1, IGF2
24	rheumatoid arthritis	31.2	MBL2, HLA-DRB1, CRP, LTA
25	acanthosis nigricans	31.1	LEP, BAIAP2L1, INS, INSR, IGF1, SHBG
26	hypothyroidism	30.7	RETN, LEP, APOB, GHRL, TPO, SHBG
27	periodontitis	30.4	IL10, IL1B, IL6, IL8, CCL2, TNF
28	ischemic heart disease	30.1	RETN, SERPINE1, IL2RB, APOA1, APOB, HP
29	diabetes, type 2	30.0	GCG, SELE, KCNJ11, INS, IL18, ALB
30	autonomic dysfunction	29.9	SERPINE1, INS, INSR, IL6, APOA1, ALB
31	maturity-onset diabetes of the young	29.9	GCK, GCG, KCNJ11, IRS1, INS, IAPP
32	acute insulin response	29.9	GCG, KCNJ11, UCP2, INS, GLUD1, CRP
33	congestive heart failure	29.6	UTS2, APLN, HMGCR, TNFRSF11B, EDN1, ACE
34	glucose intolerance	29.6	GCG, APOB, GHRL, CP, GAST
35	vascular disease	29.5	RETN, VWF, SELE, SERPINC1, SERPINE1, NAMPT
36	hyperinsulinemic hypoglycemia	29.5	INS, IGF2, SST, ABCC8, GAST
37	addison's disease	29.4	PCSK1, BGLAP, MICA, INS, HLA-A, HLA-DQA1
38	fetal macrosomia	29.4	LEP, INS, INSR, IGF2, IGF1, GLS2
39	immunodeficiency	29.4	PARP1, MIF, INS, INSR, IL10, IL18
40	diabetes mellitus, noninsulin-dependent	29.3	IRS1, HNF4A, ABCC8, SLC2A4, NEUROD1
41	hepatitis c	29.3	SERPINA1, IL10, IL18, FAS, HP, HLA-A
42	hyperinsulinism	29.2	RETN, GCK, GCG, SELE, SERPINE1, KCNJ11
43	arthritis	29.2	SERPINA1, IL1B, IL6, IL8, TNF
44	pancreatic agenesis	29.1	GCK, KCNJ11, INS, PDX1, ABCC8
45	peripheral neuropathy	29.0	RETN, SELE, INS, IL10, IL6, APOA1
46	periodontal disease	29.0	SERPINB2, BGLAP, IL18, IL1B, IL6, IL8
47	peripheral vascular disease	28.8	VWF, SELE, SERPINE1, APOA1, APOB, ALB
48	arterial calcification	28.8	VWF, SELE, BGLAP, KCNJ11, LEP, FTO
49	prader-willi syndrome	28.7	RETN, GCG, LEP, LEPR, INS, IL18
50	multiple sclerosis	28.6	MICA, IL1B, ICAM1, HLA-A, HLA-DQA1, HLA-DQB1

Clinical features from OMIM: 125851

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chromium picolinate

MalaCards organs/tissues related to gestational diabetes:

²²

MGI Mouse Phenotypes related to gestational diabetes:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	CPB2, NEUROD1, HHEX, GAD2, PDGFB, PPARGC1A
2	renal/urinary system phenotype	MP:0005367	10.3	NEUROD1, INS, FOXC2, CDKN2B, FTO, MSTN
3	hematopoietic system phenotype	MP:0005397	10.1	PDGFB, HLA-DQB1, HLA-DQA1, IGF2, MIF, CDKN2B
4	endocrine/exocrine gland phenotype	MP:0005379	10.1	GGT1, GAD2, AFP, MED1, CDKAL1, CDKN2B
5	embryogenesis phenotype	MP:0005380	9.8	PRL, PPARD, APLNR, APLN, MED1, FOXC2
6	no phenotypic analysis	MP:0003012	9.8	GHSR, HMGA1, PTPN3, SST, NTS, PPARG
7	pigmentation phenotype	MP:0001186	9.6	CCL2, PDGFB, CP, GGT1, FAS, APOB
8	integument phenotype	MP:0010771	9.6	OXT, PDX1, PPARD, SREBF2, FAS, IL2RB
9	liver/biliary system phenotype	MP:0005370	9.5	GHR, FSTL3, MSTN, CEBPA, SERPINC1, GCK
10	limbs/digits/tail phenotype	MP:0005371	8.9	TNFRSF11B, LTA, HFE, PRG4, GGT1, GHR
11	skeleton phenotype	MP:0005390	8.8	HNF1A, GHSR, TNFRSF11B, PTPN3, CYP27B1, PPARG
12	immune system phenotype	MP:0005387	8.2	GGT1, GAST, GAD2, PPARD, PPARA, CYP27B1
13	nervous system phenotype	MP:0003631	8.2	VWF, HLA-DQB1, DDIT3, NTS, PDGFA, LTA
14	reproductive system phenotype	MP:0005389	8.1	GAD2, AFP, NOS2, PDGFA, PDGFB, AGT
15	digestive/alimentary phenotype	MP:0005381	8.0	INS, VWF, FOXC2, CDKN2A, MSTN, CEBPA
16	normal phenotype	MP:0002873	7.7	PTPN3, HLA-DQB1, HMGCR, GHRL, SST, PDX1
17	adipose tissue phenotype	MP:0005375	7.3	ADRB3, SLC2A4, TCF7L2, TGFB1, AGT, ACE
18	vision/eye phenotype	MP:0005391	7.0	PDGFB, NOS2, PLAT, PPARG, SREBF2, TNF
19	growth/size phenotype	MP:0005378	6.9	SST, FABP4, FASN, APOB, APLN, IL6
20	behavior/neurological phenotype	MP:0005386	6.9	CYB5R4, FASN, APOD, APLNR, APLN, IL6
21	muscle phenotype	MP:0005369	6.3	PPARA, FABP4, APLNR, APLN, IL6, IL18
22	mortality/aging	MP:0010768	6.2	LEP, VWF, PCSK1, GCK, KCNJ11, PARP1
23	tumorigenesis	MP:0002006	5.7	SERPINE1, LEP, LEPR, CEBPA, CDKN2B, CDKN2A
24	cellular phenotype	MP:0005384	4.3	EPO, INSR, LEP, PARP1, NAMPT, SELE
25	cardiovascular system phenotype	MP:0005385	4.2	EPO, HHEX, ADIPOQ, MED1, LNPEP, SERPINE1
26	homeostasis/metabolism phenotype	MP:0005376	1.6	GGT1, GAST, GAD2, AFP, EPO, HHEX

Articles related to gestational diabetes:

(show top 50)    (show all 330)

id	Title	Authors	Year	Affiliating Genes
1	Dysregulation of placental endothelial lipase in obes e women with gestational diabetes mellitus. (21852675)	Gauster M.... Desoye G.	2011	LIPG
2	Maternal and umbilical resistin levels do not correla te with infant birth weight either in normal pregnancies and or in pregnancies complicated with gestational diabetes. (20082598)	Vitoratos N.... Creatsas G.	2010	RETN
3	Plasma visfatin levels in pregnant women with normal glucose tolerance, gestational diabetes and pre-gestational diabetes mellitus. (20059442)	Coskun A.... Arikan D.C.	2010	NAMPT
4	The ghrelin gene allele 51Q (rs34911341) is a protect ive factor against the development of gestational diabetes. (20152820)	dos Santos I.C.... Picheth G.	2010	GHRL
5	Relationship between the inhibition of NF-kappaB and insulin resistance in uterrus of rats with gestational diabetes mellitus (20230686)	Wei B.... Chen B.L.	2010	NFKB1
6	Visfatin in gestational diabetes: serum level and mRNA expression in fat and placental tissue. (19185944)	Telejko B.... Gorska M.	2009	NAMPT
7	Circulating pro- and anti-inflammatory cytokines in Polish women with gestational diabetes. (18446686)	Kuzmicki M.... Gorska M.	2008	IL6, IL18
8	Comparison of metformin and insulin in the treatment of gestational diabetes: a retrospective, case-control study. (18795211)	Tertti K.... RAPnnemaa T.	2008	INS
9	Safety of glyburide for gestational diabetes: a meta- analysis of pregnancy outcomes. (18349305)	Moretti M.E.... Koren G.	2008	INS
10	The incidence of placental abnormalities, maternal and cord plasma malondialdehyde and vascular endothelial growth factor levels in women with gestational diabetes mellitus and nondiabetic controls. (18196904)	Madazli R.... Ocak V.	2008	EPO
11	Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes. (18437353)	Krzyzanowska K.... Schernthaner G.	2008	TTR, RBP4
12	Antioxidant status and circulating lipids are altered in human gestational diabetes and macrosomia. (17761369)	Grissa O.... Khan N.A.	2007	SOD1
13	Circulating monocyte chemoattractant protein-1 in women with gestational diabetes. (18292825)	Telejko B.... Gorska M.	2007	CCL2
14	Normal secretion of the incretin hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 during gestational diabetes mellitus. (17484514)	Cypryk K.... LewiA8ski A.	2007	GCG
15	Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery (18159847)	Okruszko A.... Kretowski A.	2007	GCK, INS
16	Elevated serum levels of visfatin in gestational diabetes: a comparative study across various degrees of glucose tolerance. (17334748)	Lewandowski K.C.... Randeva H.S.	2007	NAMPT
17	Association of insulin receptor substrate-1 G972R variant with baseline characteristics of the patients with gestational diabetes mellitus. (16522427)	Tok E.C.... Dilek S.	2006	IRS1
18	Effect of pioglitazone on pancreatic beta-cell functi on and diabetes risk in Hispanic women with prior gestational diabetes. (16443789)	Xiang A.H.... Buchanan T.A.	2006	INS
19	Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. (16170833)	McLachlan K.A.... Alford F.P.	2006	TNF, LEP, CRP
20	Common variants in MODY genes increase the risk of gestational diabetes mellitus. (16752173)	Shaat N.... Groop L.	2006	GCK, HNF4A, HNF1A
21	PPAR-gamma2 Pro12Ala polymorphism is associated with weight gain in women with gestational diabetes mellitus. (16678327)	Tok E.C.... Dilek S.	2006	PPARG
22	IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes. (16092045)	Gragnoli C.... Habener J.F.	2005	PDX1
23	Gestational diabetes mellitus is associated with increased C-reactive protein concentrations in the third but not second trimester. (16313251)	Leipold H.... Kautzky-Willer A.	2005	CRP
24	Postpartum maternal plasma leptin levels and their relationship to gestational diabetes mellitus (15858242)	Kinalski M.... Kinalska I.	2004	LEP
25	Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. (15272035)	Vasquez G.... Sobrevia L.	2004	SLC29A1, SLC7A1
26	Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. (14984444)	Ben-Haroush A.... Hod M.	2004	INS
27	Maternal serum tumor necrosis factor-alpha concentration and correlation with insulin resistance in gestational diabetes (15634497)	Wang S.L.... Qu X.	2004	TNF, INS
28	Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus. (12730484)	Catalano P.M.... King J.	2003	INS
29	C-reactive protein and gestational diabetes: the central role of maternal obesity. (12915627)	Retnakaran R.... Zinman B.	2003	IL6, CRP
30	Study on the gestational diabetes mellitus and histocompatibility human leukocyte antigen DRB allele polymorphism (12133402)	Song D.... Jiao S.	2002	HLA-DRB1, HLA-DRB5, HLA-DRB3
31	Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. (11832353)	Catalano P.M.... Friedman J.E.	2002	IRS1
32	Women diagnosed with gestational diabetes mellitus do not carry antibodies against minor islet cell antigens. (12021124)	Balaji M.... Sanjeevi C.B.	2002	GAD2, PTPRN, PTPN3
33	A randomized controlled trial using glycemic plus fetal ultrasound parameters versus glycemic parameters to determine insulin therapy in gestational diabetes with fasting hyperglycemia. (11679455)	Kjos S.L.... Buchanan T.A.	2001	INS
34	Gestational diabetes mellitus in the last trimester - a feature of maternal iron excess? (11318843)	Lao T.T.... Tam K.F.	2001	TF
35	Insulin-sensitivity index and carbohydrate and lipid metabolism in gestational diabetes. (10756494)	Bartha J.L.... Moreno-Corral L.	2000	INS
36	Association of glucokinase gene with gestational diabetes mellitus in Chinese (11263168)	Han H.... Ji L.	1999	GCK
37	Metabolic and immunologic effects of insulin lispro in gestational diabetes. (10480503)	Jovanovic L.... Bastyr E.J.	1999	INS
38	Predictive value of human leukocyte antigen class II typing for the development of islet autoantibodies and insulin-dependent diabetes postpartum in women with gestational diabetes. (10404800)	Ferber K.M.... Ziegler A.G.	1999	INS
39	High prevalence of polycystic ovaries and associated clinical, endocrine, and metabolic features in women with previous gestational diabetes mellitus. (9543131)	Holte J.... Berne C.	1998	INS
40	Gestational diabetes mellitus and gene mutations which affect insulin secretion. (9237779)	Allan C.J.... Garvey W.T.	1997	GCK, INS
41	Pronounced insulin resistance and inadequate beta-cell secretion characterize lean gestational diabetes during and after pregnancy. (9353615)	Kautzky-Willer A.... Ludvik B.	1997	INS
42	Assessment of therapy in gestational diabetes by substrate and hormone responses to a standardized test meal. (9371476)	Nord E.... Persson B.	1997	INS
43	Glucocorticoid-induced ketoacidosis in gestational diabetes: sequela of the acute treatment of preterm labor. A case report. (9167100)	Bedalov A.... Balasubramanyam A.	1997	INS
44	Islet cell autoimmunity in women with gestational diabetes and risk of progression to insulin-dependent diabetes mellitus. (9013072)	Mauricio D.... de Leiva A.	1996	INS
45	Insulin receptor binding from mid-term and full-term placentas of patients with gestational diabetes mellitus and normal pregnant women. (8584010)	l-Attas O.S.	1995	INSR
46	Using glucose tolerance test results to predict insulin requirement in women with gestational diabetes. (8546639)	Tan Y.Y.... Yeo G.S.	1995	INS
47	Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning. (8150222)	Chiu K.C.... Permutt M.A.	1994	GCK
48	Prevalence and predictive value of islet cell antibod ies and insulin autoantibodies in women with gestational diabetes. (7955972)	Damm P.... lsted-Pedersen L.	1994	INS
49	Identification of glucokinase mutations in subjects with gestational diabetes mellitus. (8495817)	Stoffel M.... Bell G.I.	1993	GCK
50	Risk factors for gestational diabetes in black population. (2261842)	Bell D.S.... Acton R.T.	1990	APOA1, INS

Genes related to gestational diabetes according to GeneCards:

(show top 50)    (show all 158)

id	Symbol	Description	Score	GeneCards Section Context
1	LNPEP	leucyl/cystinyl aminopeptidase	11.0	Publications
2	ATHS	atherosclerosis susceptibility (lipoprotein associated)	11.0	Publications
3	HLA-DRB2	major histocompatibility complex, class II, DR beta 2 (pseudogene)	11.0	Publications
4	HLA-DRB9	major histocompatibility complex, class II, DR beta 9 (pseudogene)	11.0	Publications
5	NAMPT	nicotinamide phosphoribosyltransferase	11.0	Publications
6	GCK	glucokinase (hexokinase 4)	11.0	Publications
7	IGKV2D-29	immunoglobulin kappa variable 2D-29	11.0	Publications
8	CYP2R1	cytochrome P450, family 2, subfamily R, polypeptide 1	11.0	Publications
9	RBP4	retinol binding protein 4, plasma	11.0	Publications
10	FSTL3	follistatin-like 3 (secreted glycoprotein)	11.0	Publications
11	ZNRD1	zinc ribbon domain containing 1	11.0
12	GLS2	glutaminase 2 (liver, mitochondrial)	11.0
13	KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	11.0	Publications
14	CAPN10	calpain 10	11.0	Publications
15	SLC29A1	solute carrier family 29 (nucleoside transporters), member 1	11.0	Publications
16	GGCT	gamma-glutamylcyclotransferase	11.0
17	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	11.0	Publications
18	HHEX	hematopoietically expressed homeobox	11.0	Publications
19	HLA-DRB6	major histocompatibility complex, class II, DR beta 6 (pseudogene)	11.0	Publications
20	SERPINA12	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	11.0	Publications
21	GIP	gastric inhibitory polypeptide	11.0	Publications
22	PTPRN	protein tyrosine phosphatase, receptor type, N	11.0	Publications
23	NUCB2	nucleobindin 2	11.0	Publications
24	PRG4	proteoglycan 4	11.0
25	INS	insulin	11.0	Publications
26	ORM1	orosomucoid 1	11.0	Publications
27	IAPP	islet amyloid polypeptide	11.0	Publications
28	APLNR	apelin receptor	11.0	Publications
29	APLN	apelin	11.0	Publications
30	HNF1A	HNF1 homeobox A	11.0	Publications
31	CPB2	carboxypeptidase B2 (plasma)	11.0	Publications
32	GTF3A	general transcription factor IIIA	11.0	Publications
33	FABP4	fatty acid binding protein 4, adipocyte	11.0	Publications
34	MSTN	myostatin	11.0	Publications
35	LIPG	lipase, endothelial	11.0	Publications
36	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
37	NEUROD1	neuronal differentiation 1	11.0	Publications
38	AHSG	alpha-2-HS-glycoprotein	11.0	Publications
39	MTNR1B	melatonin receptor 1B	11.0	Publications
40	RETN	resistin	11.0	Publications
41	CYB5R4	cytochrome b5 reductase 4	11.0	Publications
42	ADRB3	adrenoceptor beta 3	11.0	Publications
43	UTS2	urotensin 2	11.0	Publications
44	TCF20	transcription factor 20 (AR1)	11.0	Publications
45	APOD	apolipoprotein D	11.0	Publications
46	UTS2D	urotensin 2 domain containing	11.0	Publications
47	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
48	ADIPOR1	adiponectin receptor 1	11.0	Publications
49	BAIAP2L1	BAI1-associated protein 2-like 1	11.0	Publications
50	INSR	insulin receptor	11.0	Publications

Pathways related to gestational diabetes according to GeneDecks:

(show top 50)    (show all 115)

id	Pathway	Score	Top Affiliating Genes
1	Maturity onset diabetes of the young20	11.0	HHEX, NEUROD1, PDX1, HNF1A, IAPP, HNF4A
2	Adipocytokines & Insulin Signaling37	10.9	ADIPOQ, SLC2A4, INSR, INS, IRS1, LEP
3	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	10.9	INS, IRS1, KCNJ11, HNF1A, HNF4A, ABCC8
4	Type II diabetes mellitus20	10.8	IRS1, ABCC8, PDX1, INS, KCNJ11, GCK
5	Graft-versus-host disease20	10.7	HLA-DQA1, HLA-DRB5, HLA-DRB3, HLA-A
6	Glucose / Energy Metabolism3	10.6	PPARG, SLC2A4, NEUROD1, WFS1, ADIPOQ, GAD2
7	Development Leptin signaling via PI3K-dependent pathway10	10.5	KCNJ11, PIK3R1, LEPR, CEBPA, IRS1, SLC2A4
8	Development_Leptin signaling via PI3K-dependent pathway41	10.4	LEPR, IRS1, CEBPA, SLC2A4, NFKB1, LEP
9	Adipocytokine signaling pathway20	10.2	SLC2A4, NFKB1, ADIPOQ, PPARA, PPARGC1A, TNF
10	Selected targets of HNF110	10.1	APOA1, CRP, HNF1A, ALB, IAPP, IGFBP1
11	Selected targets of C/EBPalpha10	10.0	SERPINC1, CEBPA, FABP4, APOB, RETN, ALB
12	Transcription_PPAR Pathway41	9.9	PPARG, PIK3R1, IRS1, PDGFRB, MED1, PPARD
13	THC Differentiation Pathway36	9.8	HLA-DRB3, HLA-DRB5, TNF, HLA-DRB1, IL10, IL18
14	Akt Signaling36	9.6	PDGFA, PDGFRB, LTA, PDGFB, IL6, IL2RB
15	Allograft rejection20	9.4	HLA-DQB1, HLA-DQA1, HLA-A, FAS, IL10, HLA-DRB3
16	JNK Pathway36	9.4	TGFB1, PDGFRB, PDGFB, IL6, IRS1, UTS2
17	Autoimmune thyroid disease20	9.4	IL10, FAS, HLA-A, HLA-DQB1, HLA-DRB1, HLA-DRB3
18	Selected targets of GCR-alpha10	9.4	INS, INSR, IL1B, IL6, IL8, GHR
19	Type I diabetes mellitus20	9.3	HLA-DRB5, TNF, PTPRN, LTA, GAD2, HLA-DRB3
20	PPAR Pathway36	9.3	UTS2, PIK3R1, IL6, IGF2, IGF1, PPARG
21	Asthma20	9.3	HLA-DRB3, HLA-DRB5, TNF, HLA-DQB1, HLA-DRB1, HLA-DQA1
22	Molecular Mechanisms of Cancer36	9.2	CDKN2A, CDKN2B, PDGFB, IL6, IGF2, PDGFA
23	PGC1Alpha Pathway36	9.2	INSR, PPARA, PPARGC1A, IL8, SLC2A4, IL2RB
24	Pathways in cancer20	9.2	TCF7L2, PPARD, FAS, CDKN2B, CEBPA, PIK3R1
25	Immune response MIF-mediated glucocorticoid regulation10	9.1	MIF, IL8, IL6, TNF, NOS2, NFKB1
26	Immune response_MIF-mediated glucocorticoid regulation41	9.1	NFKB1, IL6, NOS2, TNF, MIF, ICAM1
27	African trypanosomiasis20	8.9	SELE, IL18, IL1B, APOA1, FAS, IL10
28	NFAT in Immune Response36	8.7	IGF1, TGFB1, PDGFRB, PDGFB, HLA-DRB5, HLA-DRB3
29	Apoptotic Pathways in Synovial Fibroblasts36	8.6	PDGFA, IGF2, TGFB1, IL6, PIK3R1, UTS2
30	Immune response IL-1 signaling pathway10	8.6	TNF, IL8, CP, IL6, EDN1, IL1B
31	Immune response_IL-1 signaling pathway41	8.6	NFKB1, IL1B, IL6, IL8, TNF, NOS2
32	Intestinal immune network for IgA production20	8.5	TGFB1, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, IL6
33	Leishmaniasis20	8.3	NFKB1, NOS2, TGFB1, HLA-DRB5, HLA-DRB3, HLA-DRB1
34	Toxoplasmosis20	8.2	IL10, TNF, NOS2, TGFB1, NFKB1, HLA-DRB5
35	ERK Signaling36	8.2	PRG4, PDGFRB, IL6, TGFB1, CAPN10, NFKB1
36	MAPK Signaling36	8.1	PDGFRB, LTA, IL6, TGFB1, TCF20, PRG4
37	Influenza A20	8.0	FAS, IL8, IL6, NFKB1, TNF, HLA-DRB3
38	Tuberculosis20	8.0	HLA-DRB5, CYP27B1, NOS2, NFKB1, TGFB1, HLA-DRB3
39	Rheumatoid arthritis20	7.8	HLA-DRB5, TNF, TGFB1, IL1B, HLA-DRB3, HLA-DRB1
40	Malaria20	7.8	ICAM1, TGFB1, IL8, SELE, TNF, CCL2
41	Rho Family GTPases36	7.1	CCL2, IGF2, NFKB1, PDGFA, IL1B, IL10
42	PAK Pathway36	7.0	IGF2, PIK3R1, UTS2, IL6, IL10, IL18
43	p38 Signaling36	7.0	IL2RB, IL1B, TGFB1, IL18, UTS2, IL10
44	Tec Kinases Signaling36	7.0	IGF1, PIK3R1, TGFB1, PDGFRB, PDGFB, PDGFA
45	TGF-Beta Pathway36	6.9	UTS2, IL6, IL2RB, IL1B, CCL2, IGF2
46	MAPK Family Pathway36	6.9	IGF2, PDGFA, IL8, IL6, CCL2, IL2RB
47	Antioxidant Action of Vitamin-C36	6.8	SLC2A4, IL6, UTS2, NFKB1, PDGFA, PDGFB
48	Chagas disease (American trypanosomiasis)20	6.7	NOS2, TNF, CCL2, IL8, IL6, IL1B
49	Cytokine-cytokine receptor interaction20	6.5	LEP, LEPR, IL10, IL18, IL1B, IL2RB
50	JAK-STAT Pathway36	6.3	IGF1, EPO, INSR, IL10, UTS2, PRL

Compounds related to gestational diabetes according to GeneDecks:

(show top 50)    (show all 496)

id	Compound	Score	Top Affiliating Genes
1	sulfonylurea32	10.6	GCK, GCG, KCNJ11, IRS1, IAPP, GLUD1
2	pioglitazone32 9 9	12.5	RETN, GCG, RBP4, NAMPT, LEP, IRS1
3	citrate32	10.3	GCK, INSR, CAT, GLS2, GLUD1, HP
4	carbohydrates32	10.3	SELE, UCP2, FASN, MBL2, GHR, TF
5	glycogen32 18	11.3	PIK3R1, RETN, GCK, GCG, LNPEP, LEPR
6	sodium nitroprusside32	10.2	VWF, IRS1, CAT, SST, ACP1, TF
7	rapamycin32 42	11.1	GCG, MSTN, IRS1, INS, IL2RB, FASN
8	endotoxin32	10.1	RETN, SERPINB2, LEPR, MIF, IL18, IL2RB
9	n acetylcysteine32	10.0	VWF, SELE, SERPINC1, UTS2, CDKN2A, IRS1
10	triacylglycerol32	10.0	GCG, RBP4, SERPINE1, LIPG, LEP, LEPR
11	gnrh32	9.9	PCSK1, GCG, SERPINE1, LEP, LEPR, INS
12	bezafibrate32 9 9	11.8	SERPINE1, UCP2, INS, APOA1, APOB, HNF4A
13	progesterone32 42 9 18 9	13.8	PIK3R1, PCSK1, GCK, RBP4, SERPINB2, LNPEP
14	streptozotocin32	9.7	GCK, GCG, UCP2, IRS1, INS, INSR
15	epinephrine32 9 18 9	12.7	GCG, SELE, LEP, INS, INSR, APOB
16	fatty acid32	9.6	RETN, GCK, GCG, RBP4, NAMPT, LIPG
17	glutamate32	9.6	PIK3R1, GCK, GCG, KCNJ11, LEP, LEPR
18	palmitate32	9.6	GCG, SELE, UCP2, IRS1, APOA1, FASN
19	acipimox32	9.5	GCG, LEP, INS, APOA1, APOB, IGF1
20	calcium32 9 18 9	12.4	RETN, VWF, PCSK1, GCK, RBP4, SERPINB2
21	telmisartan32 9 9	11.4	LEP, INS, ALB, PPARG, PPARA, CRP
22	gliclazide32 34 9 9	12.3	SELE, KCNJ11, INS, INSR, ICAM1, ALB
23	fenofibrate32 9 9	11.2	RETN, SELE, SERPINE1, LEP, UCP2, INS
24	aspartate32	9.1	PIK3R1, RETN, RBP4, KCNJ11, CDKN2A, IL18
25	h2o232	9.1	PIK3R1, VWF, GCK, SERPINB2, SERPINA1, UTS2
26	cysteine32	9.0	GCK, GCG, RBP4, SERPINA1, UTS2, BGLAP
27	phosphatidylinositol32	8.9	PIK3R1, RETN, NAMPT, LEP, LEPR, BAIAP2L1
28	rosiglitazone32 9 18 9	11.8	RETN, RBP4, SELE, SERPINE1, NAMPT, UCP2
29	vitamin a32 9 18 9	11.7	RETN, VWF, RBP4, SERPINA1, LEP, LCN2
30	ibmx32	8.6	PCSK1, GCG, IRS1, INS, INSR, IL1B
31	acth32	8.5	PCSK1, SERPINA1, LNPEP, LEP, LEPR, MIF
32	arachidonic acid32 9 18 9	11.4	VWF, SERPINA1, LIPG, UCP2, MIF, IL1B
33	fibrinogen32	8.4	RETN, SELE, SERPINC1, SERPINB2, SERPINA1, SERPINE1
34	testosterone32 9 18 9	11.4	PIK3R1, SELE, SERPINC1, BGLAP, MSTN, CDKN2A
35	prednisolone32 9 9	10.2	VWF, BGLAP, LCN2, IL10, IL18, IL2RB
36	8-isoprostane32	8.1	RETN, SELE, SERPINE1, LEP, INS, IL10
37	arginine32	8.1	VWF, PCSK1, GCK, GCG, SERPINC1, LNPEP
38	neopterin32	8.0	LCN2, IL10, IL18, IL1B, IL2RB, IL6
39	infliximab32 9 9	10.0	SELE, BGLAP, IL10, IL18, IL1B, IL2RB
40	alanine32	7.7	RETN, VWF, GCK, GCG, RBP4, SELE
41	ciglitazone32	7.6	SERPINE1, PARP1, IL1B, IL6, IL8, CCL2
42	ribonucleic acid32	7.5	PCSK1, RBP4, SERPINB2, NAMPT, LEPR, UCP2
43	pdtc32	7.3	SELE, PARP1, IL18, IL1B, IL6, IL8
44	hydrocortisone32 9 9	9.0	BGLAP, MIF, INS, INSR, IL10, IL1B
45	thymidine32 18	7.6	PIK3R1, SERPINA1, UTS2, LEPR, IRS1, MIF
46	prostacyclin32	6.6	VWF, SELE, SERPINC1, SERPINE1, LEP, INSR
47	cholesterol32 9 18 9	9.4	PIK3R1, RETN, VWF, GCK, RBP4, SELE
48	pd 98,05932	6.3	PIK3R1, GCG, SERPINE1, UTS2, PARP1, LEP
49	vitamin d32	6.0	SERPINE1, BGLAP, LEPR, INSR, MED1, IL10
50	dexamethasone32 42 34 9 9	7.7	PIK3R1, RETN, VWF, GCK, RBP4, SERPINC1

Cellular components related to gestational diabetes according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	clathrin-coated endocytic vesicle membrane	GO:030669	10.1	HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, APOB
2	transport vesicle membrane	GO:030658	10.1	SLC30A8, HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
3	ER to Golgi transport vesicle membrane	GO:012507	10.1	SREBF2, SREBF1, HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1
4	MHC class II protein complex	GO:042613	10.1	HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
5	trans-Golgi network membrane	GO:032588	10.1	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB5
6	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.0	HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-A
7	secretory granule	GO:030141	9.7	SLC30A8, OXT, TF, PLAT, GHRL, GIP
8	integral to plasma membrane	GO:005887	9.3	HLA-DRB3, TPO, TNF, PTPRN, PDGFRB, HFE
9	external side of plasma membrane	GO:009897	8.9	SLC2A4, ACE, TNF, HLA-DRB5, HLA-DRB3, HLA-DRB1
10	cell surface	GO:009986	8.7	TNF, PLAT, PDGFA, PDGFB, TGFB1, TPO
11	platelet alpha granule lumen	GO:031093	8.6	TGFB1, PDGFB, PDGFA, ALB, IGF1, SERPINE1
12	plasma membrane	GO:005886	7.4	ABCC8, PDGFRB, TNF, TPO, HLA-DRB5, HLA-DRB3
13	extracellular region	GO:005576	4.1	GAST, RETN, INS, IL18, IL1B, IL6
14	extracellular space	GO:005615	3.8	PCSK1, INS, IL10, IL18, IL1B, IL6

Biological processes related to gestational diabetes according to GeneDecks:

(show top 50)    (show all 103)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of insulin secretion	GO:032024	10.9	SLC30A8, GLUD1, TCF7L2, GCK, RBP4, GHRL
2	glucose homeostasis	GO:042593	10.8	INSR, ADIPOQ, HNF1A, WFS1, INS, IRS1
3	endocrine pancreas development	GO:031018	10.8	IL6, GCK, INS, NEUROD1, PDX1, GIP
4	energy reserve metabolic process	GO:006112	10.8	ADRB3, ABCC8, GIP, FASN, INS, LEPR
5	brown fat cell differentiation	GO:050873	10.7	ADRB3, ADIPOQ, PPARG, PPARGC1A, FABP4, CEBPA
6	glucose metabolic process	GO:006006	10.7	LEP, INS, APOD, IGF2, GHRL, TNF
7	acute-phase response	GO:006953	10.5	AHSG, CRP, MBL2, IL6, INS, CEBPA
8	cellular response to insulin stimulus	GO:032869	10.4	ADIPOQ, GCK, SLC2A4, AHSG, PPARG, GHSR
9	cholesterol metabolic process	GO:008203	10.4	APOB, CEBPA, LEPR, LEP, SREBF1, SREBF2
10	positive regulation of glucose import	GO:046326	10.4	PIK3R1, IGF1, INS, CAPN10, INSR, ADIPOQ
11	positive regulation of glycogen biosynthetic process	GO:045725	10.3	IGF2, IGF1, GCK, IRS1, INS, INSR
12	insulin secretion	GO:030073	10.2	LEP, HNF1A, CYB5R4, PDX1, SLC30A8, NEUROD1
13	response to nutrient	GO:007584	10.2	PPARG, ADIPOQ, DDIT3, SST, TNFRSF11B, HMGCR
14	response to ethanol	GO:045471	10.2	CCL2, ADIPOQ, SOD1, SLC2A4, ICAM1, RBP4
15	regulation of insulin secretion	GO:050796	10.2	TNF, IL1B, HNF4A, ABCC8, NOS2, GIP
16	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.1	IGF1, INS, CAT, PPARD, PDGFA, PDGFB
17	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.1	HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1
18	response to glucose stimulus	GO:009749	10.1	PTPRN, SLC30A8, ADIPOQ, NEUROD1, HNF4A, TGFB1
19	positive regulation of MAPK cascade	GO:043410	10.1	LEP, INS, PDGFA, ADRB3, AGT, PDGFB
20	response to testosterone stimulus	GO:033574	10.1	EPO, EDN1, INSR, MSTN, BGLAP, UTS2
21	response to estrogen stimulus	GO:043627	9.9	PTPRN, MSTN, GHRL, FAS, PPARG, EPO
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	IGF1, GHR, PDGFB, AGT, ADIPOQ, IL6
23	response to heat	GO:009408	9.7	SOD1, CPB2, MICA, CCL2, MSTN, IL1B
24	lipid metabolic process	GO:006629	9.7	APOB, SREBF2, SREBF1, HNF4A, ALB, FABP4
25	response to activity	GO:014823	9.6	CCL2, TNF, BGLAP, INSR, IL10, OXT
26	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	EDN1, ICAM1, TNF, IL1B, INSR, INS
27	positive regulation of mitosis	GO:045840	9.4	INS, INSR, EDN1, PDGFRB, PDGFB, TNF
28	negative regulation of apoptotic process	GO:043066	9.4	NEUROD1, TNF, GHRL, CAT, EPO, IL6
29	organ regeneration	GO:031100	9.4	AHSG, PPARG, CEBPA, CCL2, MED1, AFP
30	cell-cell signaling	GO:007267	9.3	LNPEP, NAMPT, PCSK1, IAPP, IL10, IL18
31	positive regulation of MAP kinase activity	GO:043406	9.3	HTR2A, PDGFA, PDGFB, PDGFRB, EDN1, TGFB1
32	positive regulation of protein kinase B signaling cascade	GO:051897	9.2	IGF1, IGF2, INSR, TNF, PDGFA, INS
33	small molecule metabolic process	GO:044281	9.2	APOA1, PCSK1, GCK, NAMPT, KCNJ11, UCP2
34	cytokine-mediated signaling pathway	GO:019221	9.1	HLA-DRB3, CCL2, PTPRN, HLA-DRB5, HLA-DQB1, ICAM1
35	cellular response to organic cyclic compound	GO:071407	9.1	IL18, IL1B, CCL2, TNF, PPARG, CEBPA
36	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	AGER, INS, TGFB1, AGT, IL1B, IL6
37	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.6	TCF7L2, SREBF2, PPARD, PPARG, PPARA, NFKB1
38	response to glucocorticoid stimulus	GO:051384	8.5	MSTN, CEBPA, BGLAP, SERPINE1, GHR, INSR
39	positive regulation of cell proliferation	GO:008284	8.5	IL6, INSR, INS, IRS1, LEP, NAMPT
40	platelet degranulation	GO:002576	8.4	SERPINE1, VWF, SERPINA1, APOA1, IGF1, ALB
41	aging	GO:007568	8.3	DDIT3, HMGCR, CCL2, APOD, IL1B, FAS
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.1	IL6, IGF1, HNF1A, HNF4A, TNF, IL1B
43	anti-apoptosis	GO:006916	8.1	IL10, SERPINB2, IL1B, FAS, CCL2, IGF1
44	platelet activation	GO:030168	8.0	IL6, SERPINE1, SERPINA1, VWF, PIK3R1, APOA1
45	response to drug	GO:042493	7.9	TNFRSF11B, EDN1, LTA, PDGFB, PPARG, SST
46	response to hypoxia	GO:001666	7.7	UTS2, LEP, IL18, SERPINA1, IL1B, CRP
47	inflammatory response	GO:006954	7.6	SELE, MIF, IL10, IL6, ORM1, TGFB1
48	negative regulation of cell proliferation	GO:008285	7.6	TNF, CYP27B1, SST, PDX1, AGT, TGFB1
49	blood coagulation	GO:007596	7.6	PLAT, PDGFA, SERPINC1, PIK3R1, VWF, PDGFB
50	positive regulation of transcription, DNA-dependent	GO:045893	7.4	HNF4A, HMGA1, TNF, PPARGC1A, PPARG, PPARA

Molecular functions related to gestational diabetes according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin binding	GO:043559	10.5	IDE, INSR, PCSK1, PIK3R1
2	transcription regulatory region DNA binding	GO:044212	10.3	HHEX, TCF7L2, NFKB1, PPARG, TNF, HNF4A
3	protease binding	GO:002020	10.1	TNF, INS, SERPINE1, SERPINA1, SERPINC1
4	insulin-like growth factor receptor binding	GO:005159	10.0	IGF1, IGF2, INSR, INS, IRS1, PIK3R1
5	MHC class II receptor activity	GO:032395	10.0	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1
6	insulin receptor binding	GO:005158	9.9	IGF1, IGF2, ENPP1, INS, IRS1, PIK3R1
7	receptor binding	GO:005102	9.8	CAT, HNF4A, HLA-A, NOS2, PDGFRB, LTA
8	transcription factor binding	GO:008134	9.7	HHEX, NEUROD1, TCF7L2, PPARGC1A, DDIT3, HMGA1
9	eukaryotic cell surface binding	GO:043499	9.4	EPO, ADIPOQ, TGFB1, PDGFB, PDGFA, MBL2
10	hormone activity	GO:005179	9.3	RETN, SST, EDN1, AGT, TTR, PRL
11	cytokine activity	GO:005125	9.1	ADIPOQ, EDN1, LTA, TNFRSF11B, TNF, IL6
12	drug binding	GO:008144	9.0	PPARD, PPARA, PPARG, ALB, HTR2A, ACE
13	protein homodimerization activity	GO:042803	8.9	PDGFA, PDGFB, SHBG, TGFB1, SOD1, SLC30A8
14	growth factor activity	GO:008083	8.1	TGFB1, AGT, PDGFB, PDGFA, IGF1, IGF2
15	protein binding	GO:005515	3.6	PPARG, PPARA, CRP, PLAT, NOS2, NFKB1