GDM
MCID: GST033
MIFTS: 63

Gestational Diabetes (GDM) malady

Genetic diseases (common), Metabolic diseases categories
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Summaries for Gestational Diabetes

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Wikipedia:65 Gestational diabetes (or gestational diabetes mellitus, GDM) is a condition in which women without... more...

MalaCards based summary: Gestational Diabetes, also known as diabetes mellitus, gestational, is related to polycystic ovary syndrome and glucose intolerance. An important gene associated with Gestational Diabetes is GCK (glucokinase (hexokinase 4)), and among its related pathways are Insulin-mediated glucose transport and IL-9 Signaling Pathways. The compounds chromium picolinate and preproinsulin have been mentioned in the context of this disorder. Affiliated tissues include testes, placenta and ovary, and related mouse phenotypes are adipose tissue and liver/biliary system.

Description from OMIM:46 125851

Aliases & Classifications for Gestational Diabetes

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Gestational Diabetes, Aliases & Descriptions:

Name: Gestational Diabetes 8 10 62
Diabetes Mellitus, Gestational 9 22 46 62
Maternal Gestational Diabetes Mellitus 8 62
 
Gdm 8 38
Gestational Diabetes Mellitus 8
Diabetes Gestational 44


Classifications:



External Ids:

Disease Ontology8 DOID:11714
MeSH34 D016640
NCIt39 C34942

Related Diseases for Gestational Diabetes

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Diseases related to Gestational Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome30.6CAPN10, INS
2glucose intolerance30.6RBP4, CAPN10, INS, GCK
3hyperglycemia30.6GCK, INS, NAMPT, KCNJ11
4hyperinsulinism30.5INS, KCNJ11, GCK
5insulin resistance30.4NAMPT, FOXC2, CAPN10, GCK, RBP4, INS
6diabetes mellitus30.3HHEX, GCK, RBP4, MTNR1B, CAPN10, FOXC2
7hypoglycemia30.3KCNJ11, INS, GCK
8hyperinsulinemic hypoglycemia30.2INS, GCK, KCNJ11
9maturity-onset diabetes of the young30.1INS, KCNJ11, GCK
10hypertriglyceridemia30.1FOXC2, ATHS, INS
11obesity30.1KCNJ11, INS, NAMPT, FOXC2, GCK, RBP4
12infertility29.9INS, CAPN10, LNPEP
13atherosclerosis29.9INS, RBP4, ATHS, CAPN10, NAMPT
14type 2 diabetes mellitus29.3KCNJ11, GCK, INS, NAMPT, CAPN10, RBP4
15fetal macrosomia10.6
16gestational diabetes insipidus10.6
17hypertension10.5
18eclampsia10.5
19diabetes insipidus10.5
20endotheliitis10.5
21pre-eclampsia10.5
22periodontitis10.3
23thyroiditis10.3
24blindness10.3
25familial hyperinsulinism10.3KCNJ11, GCK
26pancreatitis10.3
27permanent neonatal diabetes mellitus10.2INS, KCNJ11
28hyperammonemia multi-gene panels10.2KCNJ11, GCK
29diabetic ketoacidosis10.2
30hellp syndrome10.2
31acanthosis nigricans10.2
32cryptorchidism10.2
33cholestasis10.2
34maturity-onset diabetes of the young, type 210.2
35type 1 diabetes mellitus10.2GCK, INS
36fatty liver disease10.1INS, RBP4
37neonatal diabetes mellitus10.1INS, GCK, KCNJ11
38coronary artery anomaly10.1INS, ATHS, NAMPT
39hyperuricemia10.1GCK, INS
40insulinoma10.0KCNJ11, INS, GCK
41deficiency anemia10.0
42diabetic neuropathy10.0
43diabetic retinopathy10.0
44holoprosencephaly10.0
45acute pancreatitis10.0
46renal agenesis10.0
47intrahepatic cholestasis10.0
48central pontine myelinolysis10.0
49proliferative diabetic retinopathy10.0
50postpartum depression10.0

Graphical network of the top 20 diseases related to Gestational Diabetes:



Diseases related to gestational diabetes

Symptoms for Gestational Diabetes

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Clinical features from OMIM:

125851

Drugs & Therapeutics for Gestational Diabetes

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Drug clinical trials:

Search ClinicalTrials for Gestational Diabetes

Search NIH Clinical Center for Gestational Diabetes

Genetic Tests for Gestational Diabetes

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Genetic tests related to Gestational Diabetes:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Gestational22

Anatomical Context for Gestational Diabetes

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MalaCards organs/tissues related to Gestational Diabetes:

32
Testes, Placenta, Ovary, Endothelial, Skeletal muscle, Thyroid, Breast, Adipocyte, Monocytes, Heart, Smooth muscle, Liver, Skin, T cells, B cells, Neutrophil

Animal Models for Gestational Diabetes or affiliated genes

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MGI Mouse Phenotypes related to Gestational Diabetes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.2CAPN10, FOXC2, INS, KCNJ11
2MP:00053708.8INS, FOXC2, CAPN10, GCK, HHEX
3MP:00053698.7KCNJ11, INS, FOXC2, RBP4, HHEX
4MP:00053798.5HHEX, KCNJ11, INS, NAMPT, CAPN10, GCK
5MP:00053858.1LNPEP, KCNJ11, INS, FOXC2, CAPN10, RBP4
6MP:00053767.7LNPEP, KCNJ11, INS, NAMPT, FOXC2, CAPN10

Publications for Gestational Diabetes

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Articles related to Gestational Diabetes:

(show top 50)    (show all 972)
idTitleAuthorsYear
1
Glutamic acid decarboxylase autoantibody-positivity post-partum is associated with impaired I^-cell function in women with gestational diabetes mellitus. (25345799)
2014
2
Improving postpartum glucose screening after gestational diabetes mellitus: a cohort study to evaluate the multicentre IMPACT initiative. (25393823)
2014
3
Accelerometry-measured physical activity and inflammation after gestational diabetes. (24070759)
2013
4
Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta. (23954530)
2013
5
Circadian clock gene expression is impaired in gestational diabetes mellitus. (23323702)
2013
6
An association between gestational diabetes mellitus and long-term maternal cardiovascular morbidity. (23749791)
2013
7
A composite risk assessment model to screen for gestational diabetes mellitus among Mediterranean women. (23279935)
2013
8
Ultrasound-guided compared to conventional treatment in gestational diabetes leads to improved birthweight but more insulin treatment: systematic review and meta-analysis. (24372329)
2013
9
Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance. (23560057)
2013
10
Levels of thrombin activatable fibrinolysis inhibitor in gestational diabetes mellitus. (23327722)
2013
11
Quantifying the impact of gestational diabetes mellitus, maternal weight and race on birthweight via quantile regression. (23762279)
2013
12
Microscopic impacts of gestational diabetes mellitus on the umbilical cord. (24292308)
2013
13
NIH consensus development conference: diagnosing gestational diabetes mellitus. (23748438)
2013
14
Circulating apelin levels are associated with cardiometabolic risk factors in women with previous gestational diabetes. (24185940)
2013
15
Simulated estimates of pre-pregnancy and gestational diabetes mellitus in the US: 1980 to 2008. (24039941)
2013
16
IADPSG criteria for diagnosing gestational diabetes mellitus and predicting adverse pregnancy outcomes. (24232664)
2013
17
Gestational diabetes and pregnancy outcome - do we have right diagnostic criteria? (23414434)
2013
18
Are Gestational Diabetes Mellitus and Preconception Diabetes Mellitus Less Common in Non-Hispanic Black Women than in Non-Hispanic White Women? (23793482)
2013
19
The importance of gestational diabetes beyond pregnancy. (24147923)
2013
20
Effect of number of abnormal oral glucose tolerance test (OGTT) values on birthweight in women with gestational diabetes. (23481057)
2013
21
Evolution of diagnostic criteria for gestational diabetes mellitus. (23600679)
2013
22
Awareness of gestational diabetes mellitus among antenatal women in a primary health center in South India. (23776868)
2013
23
Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results. (23805905)
2013
24
Clinical diagnosis of gestational diabetes. (24005127)
2013
25
Comment on: Black et al. The relative contribution of prepregnancy overweight and obesity, gestational weight gain, and IADPSG-defined gestational diabetes mellitus to fetal overgrowth. Diabetes Care 2013;36:56-62. (23881980)
2013
26
Screening tests for gestational diabetes: a systematic review for the U.S. Preventive Services Task Force. (23712349)
2013
27
Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes. (23015651)
2012
28
Physician care patterns and adherence to postpartum glucose testing after gestational diabetes mellitus in Oregon. (23071709)
2012
29
Outcome of gestational diabetes mellitus from a tertiary referral center in South India: a case-control study. (24293841)
2012
30
Perinatal maternal and neonatal outcomes in women with gestational diabetes mellitus according to fetal sex. (23089258)
2012
31
Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes. (19857477)
2010
32
Growth factor concentrations and their placental mRNA expression are modulated in gestational diabetes mellitus: possible interactions with macrosomia. (20144210)
2010
33
Association of KCNQ1 polymorphisms with the gestational diabetes mellitus in Korean women. (19850681)
2010
34
The changes of visfatin in serum and its expression in fat and placental tissue in pregnant women with gestational diabetes. (20621376)
2010
35
Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. (19709150)
2009
36
Diabetes mellitus following gestational diabetes: role of subsequent pregnancy. (18081603)
2008
37
Screening for biomarkers predictive of gestational diabetes mellitus. (18496643)
2008
38
C-reactive protein and metabolic syndrome in women with previous gestational diabetes. (16770838)
2007
39
Mild gestational diabetes as a risk factor for congenital cryptorchidism. (17032715)
2006
40
Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications. (15778860)
2005
41
Inflammatory markers in women with a recent history of gestational diabetes mellitus. (15816369)
2005
42
Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus. (15095040)
2004
43
Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. (11832353)
2002
44
Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus. (11772903)
2002
45
Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes. (12235720)
2002
46
Elevated D-glucose induces insulin insensitivity in human umbilical endothelial cells isolated from gestational diabetic pregnancies. (9481683)
1998
47
Gestational diabetes mellitus and subsequent development of overt diabetes mellitus. (9850811)
1998
48
Islet amyloid polypeptide (amylin) does not seem to be directly involved in the development of gestational diabetes mellitus. (9251946)
1997
49
Risk factors for gestational diabetes in black population. (2261842)
1990
50
Insulin receptor binding and glucose metabolism in normal human pregnancy and gestational diabetes mellitus. A review. (2073852)
1990

Variations for Gestational Diabetes

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UniProtKB/Swiss-Prot genetic disease variations for Gestational Diabetes:

64 (show all 42)
id Symbol AA change Variation ID SNP ID
1GCKp.Glu70LysVAR_003693
2GCKp.Gly80AlaVAR_003694
3GCKp.Gly80SerVAR_003695
4GCKp.Ser131ProVAR_003697
5GCKp.Gly175ArgVAR_003698
6GCKp.Val182MetVAR_003699
7GCKp.Ala188ThrVAR_003700
8GCKp.Val203AlaVAR_003701
9GCKp.Glu221LysVAR_003702
10GCKp.Val226MetVAR_003703
11GCKp.Gly227CysVAR_003704
12GCKp.Thr228MetVAR_003705
13GCKp.Glu256LysVAR_003706
14GCKp.Trp257ArgVAR_003707
15GCKp.Gly261ArgVAR_003708
16GCKp.Glu279GlnVAR_003709rs104894005
17GCKp.Gly299ArgVAR_003710
18GCKp.Glu300GlnVAR_003711
19GCKp.Glu300LysVAR_003712
20GCKp.Leu309ProVAR_003713
21GCKp.Lys414GluVAR_003714
22GCKp.Arg36TrpVAR_010584
23GCKp.Ala53SerVAR_010585
24GCKp.Tyr108HisVAR_010586
25GCKp.His137ArgVAR_010587
26GCKp.Phe150SerVAR_010588
27GCKp.Thr168ProVAR_010589
28GCKp.Thr209MetVAR_010590
29GCKp.Met210ThrVAR_010591
30GCKp.Cys213ArgVAR_010592
31GCKp.Ala259ThrVAR_010593
32GCKp.Gly261GluVAR_010594
33GCKp.Ser336LeuVAR_010595
34GCKp.Val367MetVAR_010596
35GCKp.Cys382TyrVAR_010597
36GCKp.Ala384ThrVAR_010598
37GCKp.Arg392CysVAR_010599
38GCKp.Leu164ProVAR_012350
39GCKp.Met210LysVAR_012351
40GCKp.Ile110ThrVAR_012352
41GCKp.Ala119AspVAR_012353
42GCKp.Gly385ValVAR_012354

Clinvar genetic disease variations for Gestational Diabetes:

6 (show all 88)
id Gene Name Type Significance SNP ID Assembly Location
1GCKNM_000162.3(GCK): c.683C> T (p.Thr228Met)single nucleotide variantPathogenicrs80356655GRCh37Chr 7, 44187429: 44187429
2GCKNM_000162.3(GCK): c.1002_1003delCGinsAA (p.Phe334_Val335delinsLeuMet)indelLikely pathogenicrs193922252GRCh37Chr 7, 44186078: 44186079
3GCKNM_000162.3(GCK): c.1003_1004insAA (p.Val335Glufs)insertionLikely pathogenicrs193922253GRCh37Chr 7, 44186077: 44186078
4GCKNM_000162.3(GCK): c.1003delG (p.Val335Cysfs)deletionLikely pathogenicrs193922254GRCh37Chr 7, 44186078: 44186078
5GCKNM_000162.3(GCK): c.1018A> G (p.Ser340Gly)single nucleotide variantLikely pathogenicrs193922255GRCh37Chr 7, 44186063: 44186063
6GCKNM_000162.3(GCK): c.1020-1G> Csingle nucleotide variantLikely pathogenicrs193922258GRCh37Chr 7, 44185330: 44185330
7GCKNM_000162.3(GCK): c.103A> T (p.Arg35Ter)single nucleotide variantLikely pathogenicrs193922259GRCh37Chr 7, 44193005: 44193005
8GCKNM_000162.3(GCK): c.1042A> T (p.Ile348Phe)single nucleotide variantLikely pathogenicrs193922260GRCh37Chr 7, 44185307: 44185307
9GCKNM_000162.3(GCK): c.107G> C (p.Arg36Pro)single nucleotide variantLikely pathogenicrs193922261GRCh37Chr 7, 44193001: 44193001
10GCKNM_000162.3(GCK): c.1114G> T (p.Glu372Ter)single nucleotide variantLikely pathogenicrs193922262GRCh37Chr 7, 44185235: 44185235
11GCKNM_000162.3(GCK): c.1124C> T (p.Ser375Phe)single nucleotide variantLikely pathogenicrs193922263GRCh37Chr 7, 44185225: 44185225
12GCKNM_000162.3(GCK): c.1130G> A (p.Arg377His)single nucleotide variantLikely pathogenicrs193922264GRCh37Chr 7, 44185219: 44185219
13GCKNM_000162.3(GCK): c.1136C> A (p.Ala379Glu)single nucleotide variantLikely pathogenicrs193922265GRCh37Chr 7, 44185213: 44185213
14GCKNM_000162.3(GCK): c.1142T> G (p.Met381Arg)single nucleotide variantLikely pathogenicrs193922266GRCh37Chr 7, 44185207: 44185207
15GCKNM_000162.3(GCK): c.1153G> A (p.Gly385Arg)single nucleotide variantLikely pathogenicrs193922267GRCh37Chr 7, 44185196: 44185196
16GCKNM_000162.3(GCK): c.1157T> C (p.Leu386Pro)single nucleotide variantLikely pathogenicrs193922268GRCh37Chr 7, 44185192: 44185192
17GCKNM_000162.3(GCK): c.1160C> A (p.Ala387Glu)single nucleotide variantLikely pathogenicrs193921338GRCh37Chr 7, 44185189: 44185189
18GCKNM_000162.3(GCK): c.1160C> T (p.Ala387Val)single nucleotide variantLikely pathogenicrs193921338GRCh37Chr 7, 44185189: 44185189
19GCKNM_000162.3(GCK): c.1169T> A (p.Ile390Asn)single nucleotide variantLikely pathogenicrs193921340GRCh37Chr 7, 44185180: 44185180
20GCKNM_000162.3(GCK): c.1169T> C (p.Ile390Thr)single nucleotide variantLikely pathogenicrs193921340GRCh37Chr 7, 44185180: 44185180
21GCKNM_000162.3(GCK): c.1175G> T (p.Arg392Leu)single nucleotide variantLikely pathogenicrs193922269GRCh37Chr 7, 44185174: 44185174
22GCKNM_000162.3(GCK): c.1207C> G (p.Arg403Gly)single nucleotide variantLikely pathogenicrs193922271GRCh37Chr 7, 44185142: 44185142
23GCKNM_000162.3(GCK): c.1240A> G (p.Lys414Glu)single nucleotide variantLikely pathogenicrs193922272GRCh37Chr 7, 44185109: 44185109
24GCKNM_000162.3(GCK): c.1268T> A (p.Phe423Tyr)single nucleotide variantLikely pathogenicrs193922273GRCh37Chr 7, 44184865: 44184865
25GCKNM_000162.3(GCK)indelLikely pathogenicrs193922274GRCh37Chr 7, 44184775: 44184854
26GCKNM_000162.3(GCK): c.1283_1284delGC (p.Arg428Glnfs)deletionLikely pathogenicrs193922275GRCh37Chr 7, 44184849: 44184850
27GCKNM_000162.3(GCK): c.1289T> C (p.Leu430Pro)single nucleotide variantLikely pathogenicrs193922277GRCh37Chr 7, 44184844: 44184844
28GCKNM_000162.3(GCK): c.1307T> A (p.Ile436Asn)single nucleotide variantLikely pathogenicrs193922278GRCh37Chr 7, 44184826: 44184826
29GCKNM_000162.3(GCK): c.131G> A (p.Gly44Asp)single nucleotide variantLikely pathogenicrs193922279GRCh37Chr 7, 44192977: 44192977
30GCKNM_000162.3(GCK): c.1332delC (p.Ser445Valfs)deletionLikely pathogenicrs193922280GRCh37Chr 7, 44184801: 44184801
31GCKNM_000162.3(GCK): c.1339C> G (p.Arg447Gly)single nucleotide variantLikely pathogenicrs193922281GRCh37Chr 7, 44184794: 44184794
32GCKNM_000162.3(GCK): c.1345G> A (p.Ala449Thr)single nucleotide variantLikely pathogenicrs193922282GRCh37Chr 7, 44184788: 44184788
33GCKNM_000162.3(GCK): c.1358C> T (p.Ser453Leu)single nucleotide variantLikely pathogenicrs193922283GRCh37Chr 7, 44184775: 44184775
34GCKNM_000162.3(GCK): c.1372_1373delAA (p.Lys458Glufs)deletionLikely pathogenicrs193922284GRCh37Chr 7, 44184760: 44184761
35GCKNM_000162.3(GCK): c.1386G> T (p.Met462Ile)single nucleotide variantLikely pathogenicrs193922285GRCh37Chr 7, 44184747: 44184747
36GCKp.X466Trpsingle nucleotide variantLikely pathogenic
37GCKNM_000162.3(GCK): c.146C> A (p.Thr49Asn)single nucleotide variantLikely pathogenicrs193922286GRCh37Chr 7, 44192962: 44192962
38GCKNM_000162.3(GCK): c.175C> T (p.Pro59Ser)single nucleotide variantLikely pathogenicrs193922287GRCh37Chr 7, 44192933: 44192933
39GCKNM_000162.3(GCK): c.214G> A (p.Gly72Arg)single nucleotide variantPathogenicrs193922289GRCh37Chr 7, 44192019: 44192019
40GCKNM_000162.3(GCK): c.253A> T (p.Arg85Trp)single nucleotide variantLikely pathogenicrs193922290GRCh37Chr 7, 44191980: 44191980
41GCKNM_000162.3(GCK): c.304A> T (p.Lys102Ter)single nucleotide variantLikely pathogenicrs193922291GRCh37Chr 7, 44191929: 44191929
42GCKNM_000162.3(GCK): c.322T> G (p.Tyr108Asp)single nucleotide variantLikely pathogenicrs193922292GRCh37Chr 7, 44191911: 44191911
43GCKNM_000162.3(GCK): c.393delC (p.Asp132Thrfs)deletionLikely pathogenicrs193922295GRCh37Chr 7, 44190645: 44190645
44GCKNM_000162.3(GCK): c.440G> A (p.Gly147Asp)single nucleotide variantLikely pathogenicrs193922296GRCh37Chr 7, 44190598: 44190598
45GCKNM_000162.3(GCK): c.449T> C (p.Phe150Ser)single nucleotide variantLikely pathogenicrs193922297GRCh37Chr 7, 44190589: 44190589
46GCKNM_000162.3(GCK): c.457C> T (p.Pro153Ser)single nucleotide variantLikely pathogenicrs193922300GRCh37Chr 7, 44190581: 44190581
47GCKNM_000162.3(GCK): c.463A> G (p.Arg155Gly)single nucleotide variantLikely pathogenicrs193922301GRCh37Chr 7, 44190575: 44190575
48GCKNM_000162.3(GCK): c.483G> A (p.Lys161=)single nucleotide variantLikely pathogenicrs193922302GRCh37Chr 7, 44190555: 44190555
49GCKNM_000162.3(GCK): c.509G> T (p.Gly170Val)single nucleotide variantLikely pathogenicrs193922303GRCh37Chr 7, 44189638: 44189638
50GCKNM_000162.3(GCK): c.527C> G (p.Ala176Gly)single nucleotide variantLikely pathogenicrs193922304GRCh37Chr 7, 44189620: 44189620
51GCKNM_000162.3(GCK): c.532G> A (p.Gly178Arg)single nucleotide variantLikely pathogenicrs193922305GRCh37Chr 7, 44189615: 44189615
52GCKNM_000162.3(GCK): c.542T> C (p.Val181Ala)single nucleotide variantLikely pathogenicrs193922306GRCh37Chr 7, 44189605: 44189605
53GCKNM_000162.3(GCK): c.563C> T (p.Ala188Val)single nucleotide variantLikely pathogenicrs193922307GRCh37Chr 7, 44189584: 44189584
54GCKNM_000162.3(GCK): c.57C> G (p.Ile19Met)single nucleotide variantLikely pathogenicrs193922308GRCh37Chr 7, 44193051: 44193051
55GCKNM_000162.3(GCK): c.587A> G (p.Glu196Gly)single nucleotide variantLikely pathogenicrs193922309GRCh37Chr 7, 44189451: 44189451
56GCKNM_000162.3(GCK): c.604A> G (p.Met202Val)single nucleotide variantLikely pathogenicrs193922310GRCh37Chr 7, 44189434: 44189434
57GCKNM_000162.3(GCK): c.605T> C (p.Met202Thr)single nucleotide variantLikely pathogenicrs193922311GRCh37Chr 7, 44189433: 44189433
58GCKNM_000162.3(GCK): c.615C> G (p.Asp205Glu)single nucleotide variantLikely pathogenicrs193922312GRCh37Chr 7, 44189423: 44189423
59GCKNM_000162.3(GCK): c.630G> T (p.Met210Ile)single nucleotide variantLikely pathogenicrs193922313GRCh37Chr 7, 44189408: 44189408
60GCKNM_000162.3(GCK): c.635_637delCCT (p.Ser212del)deletionLikely pathogenicrs193922314GRCh37Chr 7, 44189401: 44189403
61GCKNM_000162.3(GCK): c.645C> G (p.Tyr215Ter)single nucleotide variantPathogenicrs144723656GRCh37Chr 7, 44189393: 44189393
62GCKNM_000162.3(GCK): c.658T> C (p.Cys220Arg)single nucleotide variantLikely pathogenicrs193922315GRCh37Chr 7, 44189380: 44189380
63GCKNM_000162.3(GCK): c.659G> A (p.Cys220Tyr)single nucleotide variantLikely pathogenicrs193922316GRCh37Chr 7, 44189379: 44189379
64GCKNM_000162.3(GCK): c.661G> A (p.Glu221Lys)single nucleotide variantLikely pathogenicrs193922317GRCh37Chr 7, 44189377: 44189377
65GCKNM_000162.3(GCK): c.676G> A (p.Val226Met)single nucleotide variantPathogenicrs148311934GRCh37Chr 7, 44189362: 44189362
66GCKNM_000162.3(GCK): c.677T> C (p.Val226Ala)single nucleotide variantLikely pathogenicrs193922319GRCh37Chr 7, 44189361: 44189361
67GCKNM_000162.3(GCK): c.679+1delGdeletionLikely pathogenicrs193922320GRCh37Chr 7, 44189358: 44189358
68GCKNM_000162.3(GCK): c.694G> A (p.Ala232Thr)single nucleotide variantLikely pathogenicrs193922322GRCh37Chr 7, 44187418: 44187418
69GCKNM_000162.3(GCK): c.704T> C (p.Met235Thr)single nucleotide variantLikely pathogenicrs193922323GRCh37Chr 7, 44187408: 44187408
70GCKNM_000162.3(GCK): c.74T> G (p.Leu25Arg)single nucleotide variantLikely pathogenicrs193922325GRCh37Chr 7, 44193034: 44193034
71GCKNM_000162.3(GCK): c.752T> C (p.Met251Thr)single nucleotide variantLikely pathogenicrs193922326GRCh37Chr 7, 44187360: 44187360
72GCKNM_000162.3(GCK): c.758T> C (p.Val253Ala)single nucleotide variantLikely pathogenicrs193921400GRCh37Chr 7, 44187354: 44187354
73GCKNM_000162.3(GCK): c.758T> G (p.Val253Gly)single nucleotide variantLikely pathogenicrs193921400GRCh37Chr 7, 44187354: 44187354
74GCKNM_000162.3(GCK): c.760A> C (p.Asn254His)single nucleotide variantLikely pathogenicrs193922327GRCh37Chr 7, 44187352: 44187352
75GCKNM_000162.3(GCK): c.768G> C (p.Glu256Asp)single nucleotide variantLikely pathogenicrs193922328GRCh37Chr 7, 44187344: 44187344
76GCKNM_000162.3(GCK): c.76C> T (p.Gln26Ter)single nucleotide variantLikely pathogenicrs193922329GRCh37Chr 7, 44193032: 44193032
77GCKNM_000162.3(GCK): c.779T> C (p.Phe260Ser)single nucleotide variantLikely pathogenicrs193922330GRCh37Chr 7, 44187333: 44187333
78GCKNM_000162.3(GCK): c.787T> C (p.Ser263Pro)single nucleotide variantLikely pathogenicrs193922331GRCh37Chr 7, 44187325: 44187325
79GCKNM_000162.3(GCK): c.812T> C (p.Leu271Pro)single nucleotide variantLikely pathogenicrs193922332GRCh37Chr 7, 44187300: 44187300
80GCKNM_000162.3(GCK): c.833A> T (p.Asp278Val)single nucleotide variantLikely pathogenicrs193922333GRCh37Chr 7, 44187279: 44187279
81GCKNM_000162.3(GCK): c.871A> T (p.Lys291Ter)single nucleotide variantPathogenicrs193922335GRCh37Chr 7, 44186210: 44186210
82GCKNM_000162.3(GCK): c.907C> T (p.Arg303Trp)single nucleotide variantLikely pathogenicrs193922336GRCh37Chr 7, 44186174: 44186174
83GCKNM_000162.3(GCK): c.917T> C (p.Leu306Pro)single nucleotide variantLikely pathogenicrs193922337GRCh37Chr 7, 44186164: 44186164
84GCKNM_000162.3(GCK): c.944T> A (p.Leu315His)single nucleotide variantPathogenicrs193922338GRCh37Chr 7, 44186137: 44186137
85GCKNM_000162.3(GCK): c.947T> A (p.Phe316Tyr)single nucleotide variantLikely pathogenicrs193922339GRCh37Chr 7, 44186134: 44186134
86GCKNM_000162.3(GCK): c.952G> T (p.Gly318Trp)single nucleotide variantLikely pathogenicrs193922340GRCh37Chr 7, 44186129: 44186129
87GCKNM_000162.3(GCK): c.971T> C (p.Leu324Pro)single nucleotide variantLikely pathogenicrs193922341GRCh37Chr 7, 44186110: 44186110
88GCKGCK: c.dup_Exon2-6duplicationLikely pathogenic

Expression for genes affiliated with Gestational Diabetes

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Expression patterns in normal tissues for genes affiliated with Gestational Diabetes

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Pathways for genes affiliated with Gestational Diabetes

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Compounds for genes affiliated with Gestational Diabetes

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Compounds related to Gestational Diabetes according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1chromium picolinate4410.3GCK, INS
2preproinsulin4410.3GCK, INS
3i-app4410.3GCK, INS
4incretin4410.3GCK, INS
5fructosamine44 2411.2INS, RBP4
6repaglinide50 44 1112.2INS, KCNJ11
7gliclazide44 50 1112.1KCNJ11, INS
8glimepiride44 50 1112.1INS, KCNJ11
9niacin44 1111.1INS, NAMPT
10sulfonylurea4410.0KCNJ11, INS, GCK
11katp4410.0GCK, INS, KCNJ11
12diazoxide44 61 28 1113.0KCNJ11, INS, GCK
13tolbutamide44 28 50 1113.0GCK, INS, KCNJ11
14aicar44 24 1112.0INS, GCK
15pioglitazone28 44 50 1113.0RBP4, NAMPT, INS
16c-peptide4410.0KCNJ11, INS, GCK
17rosiglitazone28 44 50 24 1114.0RBP4, NAMPT, INS
18streptozotocin4410.0GCK, INS
19cystine449.9LNPEP, RBP4
20dehydroepiandrosterone sulfate449.8INS, RBP4
21metformin44 50 1111.8KCNJ11, INS, NAMPT, GCK
22fatty acid449.7INS, NAMPT, GCK, RBP4
23sucrose44 24 1111.7RBP4, GCK, LNPEP
24creatinine449.7INS, NAMPT, GCK, RBP4
25nicotinamide44 1110.6NAMPT, INS
26dexamethasone44 50 28 1112.6RBP4, GCK, NAMPT, INS
27leucine449.5RBP4, GCK, KCNJ11, LNPEP
28glycogen44 2410.5LNPEP, INS, CAPN10, GCK
29alanine449.2RBP4, GCK, INS, LNPEP
30arginine449.2LNPEP, KCNJ11, INS, CAPN10, GCK
31cholesterol44 28 24 1111.8RBP4, GCK, CAPN10, NAMPT, INS, ATHS
32glucose448.1RBP4, LNPEP, KCNJ11, INS, NAMPT, FOXC2
33lipid448.1LNPEP, ATHS, INS, NAMPT, FOXC2, CAPN10

GO Terms for genes affiliated with Gestational Diabetes

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Cellular components related to Gestational Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.6RBP4, GCK, CAPN10, NAMPT, KCNJ11, LNPEP

Biological processes related to Gestational Diabetes according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of gluconeogenesisGO:04572110.2GCK, INS
2positive regulation of glycolytic processGO:04582110.1GCK, INS
3positive regulation of glycogen biosynthetic processGO:04572510.1GCK, INS
4endocrine pancreas developmentGO:03101810.0GCK, INS
5embryonic heart tube developmentGO:0350509.9FOXC2, HHEX
6positive regulation of insulin secretionGO:0320249.8CAPN10, GCK, RBP4
7positive regulation of glucose importGO:0463269.8CAPN10, INS
8glucose homeostasisGO:0425939.7RBP4, GCK, MTNR1B, INS
9insulin receptor signaling pathwayGO:0082869.7FOXC2, NAMPT, INS
10regulation of insulin secretionGO:0507969.7GCK, MTNR1B, INS, KCNJ11
11cell-cell signalingGO:0072679.4LNPEP, INS, NAMPT
12small molecule metabolic processGO:0442818.7GCK, NAMPT, INS, KCNJ11, CYP2R1

Molecular functions related to Gestational Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA binding, bendingGO:0083019.8HHEX, FOXC2

Products for genes affiliated with Gestational Diabetes

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  • Antibodies
  • Proteins
  • Lysates

Sources for Gestational Diabetes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet