GDM
MCID: GST033
MIFTS: 59

Gestational Diabetes (GDM) malady

Summaries for Gestational Diabetes

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Gestational diabetes (or gestational diabetes mellitus, GDM) is a condition in which women without... more...

MalaCards: Gestational Diabetes, also known as diabetes mellitus, gestational, is related to insulin resistance and fetal macrosomia. An important gene associated with Gestational Diabetes is GCK (glucokinase (hexokinase 4)), and among its related pathways are Adipogenesis and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Description from OMIM:47 125851

Aliases & Classifications for Gestational Diabetes

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 39NCBI Bookshelf, 9diseasecard, 22GTR, 47OMIM, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

gestational diabetes 8 10 61
diabetes mellitus, gestational 9 22 47
gdm 8 39
maternal gestational diabetes mellitus 8
gestational diabetes mellitus 8
diabetes gestational 45


External Ids:

Disease Ontology8 DOID:11714
NCIt40 C34942
MeSH35 D016640

Related Diseases for Gestational Diabetes

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gestational Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.2RETN, NAMPT, INS, LEP, GCK, APLN
2fetal macrosomia30.9INS, LEP
3glucose intolerance30.8INS, RETN, RBP4, CAPN10, GCK, LEP
4polycystic ovary syndrome30.7CAPN10, LEP, INS
5atherosclerosis30.3APLN, CAPN10, LEP, ADIPOQ, INS, NAMPT
6hyperinsulinism30.3GCK, INS, RETN, LEP
7acanthosis nigricans30.2ADIPOQ, INS, LEP
8hypertriglyceridemia30.0ADIPOQ, FOXC2, ATHS, INS, LEP
9acute pancreatitis30.0RETN
10infertility30.0LNPEP, RETN, INS, LEP, CAPN10
11gestational diabetes insipidus10.5
12eclampsia10.5
13diabetes insipidus10.5
14neonatal diabetes mellitus10.4
15diabetic ketoacidosis10.1
16cryptorchidism10.1
17hypoglycemia10.1
18mody, type ii10.1
19deficiency anemia10.0
20hellp syndrome10.0
21proliferative diabetic retinopathy10.0
22wolff-parkinson-white syndrome10.0
23intrahepatic cholestasis10.0
24renal agenesis10.0
25quadriplegia10.0
26neonatal respiratory failure10.0
27placenta accreta10.0
28hypospadias10.0
29iron deficiency anemia10.0
30central pontine myelinolysis10.0
31hyperinsulinemic hypoglycemia10.0
32conn's syndrome10.0
33n syndrome10.0
34potter's syndrome10.0
35holoprosencephaly10.0
36sleep disorder10.0
37thyrotoxicosis10.0
38sirenomelia10.0
39pemphigoid gestationis10.0
40multiple endocrine neoplasia10.0
41hypoxia10.0
42sleep apnea10.0
43homocysteine plasma level10.0
44carotid intimal medial thickness10.0
45alobar holoprosencephaly10.0
46diabetes mellitus10.0ADIPOQ, HHEX, LEP, INS, NAMPT, RETN
47obesity10.0NAMPT, INS, LEP, RETN, ADIPOQ, RBP4
48type 2 diabetes mellitus10.0GCK, ADIPOQ, LNPEP, CAPN10, RBP4, NAMPT
49primary hyperoxaluria10.0INS, NAMPT, RETN, CAPN10, RBP4, LEP
50coronary artery disease,10.0NAMPT, RETN, APLN, ADIPOQ, INS, ATHS

Graphical network of the top 20 diseases related to Gestational Diabetes:



Diseases related to gestational diabetes

Clinical Features for Gestational Diabetes

Sources:
47OMIM
See all sources

Clinical features from OMIM:

125851

Drugs & Therapeutics for Gestational Diabetes

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gestational Diabetes

Drug clinical trials:

Search ClinicalTrials for Gestational Diabetes

Search NIH Clinical Center for Gestational Diabetes

Search CenterWatch for Gestational Diabetes

Genetic Tests for Gestational Diabetes

Sources:
22GTR
See all sources

Genetic tests related to Gestational Diabetes:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Gestational22

Anatomical Context for Gestational Diabetes

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gestational Diabetes:

33
Skin, Ovary, Liver, Heart, Skeletal muscle, Adipocyte, Thyroid, Breast, Placenta, Monocytes, T cells, B cells, Endothelial, Fetal liver, Fetal thyroid, Pancreatic islet

Animal Models for Gestational Diabetes or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gestational Diabetes

Sources:
51PubMed
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Articles related to Gestational Diabetes:

(show top 50)    (show all 933)
idTitleAuthorsYear
1
Maternal prepregnancy obesity and insulin treatment during pregnancy are independently associated with delayed lactogenesis in women with recent gestational diabetes mellitus. (24196401)
2014
2
Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta. (23954530)
2013
3
Diabetes nurse educators' experiences of providing care for women, with gestational diabetes mellitus, from disadvantaged backgrounds. (24313229)
2013
4
Gestational diabetes in a multiethnic population of Spain: clinical characteristics and perinatal outcomes. (23538268)
2013
5
Diagnosis of gestational diabetes mellitus: a different paradigm to consider. (24159183)
2013
6
The impact of new national guidelines on screening for gestational diabetes mellitus. (23472391)
2013
7
Effect of maternal obesity and weight gain on gestational diabetes mellitus. (23110595)
2013
8
Gestational diabetes mellitus among Norwegian women with polycystic ovary syndrome: prevalence and risk factors according to the WHO and the modified IADPSG criteria. (23636445)
2013
9
Re: Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus by Corbould A, Swinton F, Radford A, Campbell, McBeath S, Dennis A. Aust N Z J Obstet Gynaecol 2013; 53: 125-129. (24289066)
2013
10
myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes: a prospective, randomized, placebo-controlled study. (23340885)
2013
11
Universal screening of gestational diabetes mellitus: prevalence and diagnostic value of clinical risk factors. (23539927)
2013
12
Gestational diabetes mellitus--challenges in research and management. (23541040)
2013
13
Interconception care for women with prior gestational diabetes mellitus. (23631462)
2013
14
Diagnostic and prognostic performances over 9 years of a selective screening strategy for gestational diabetes mellitus in a cohort of 18,775 subjects. (23150287)
2013
15
Use of glycated hemoglobin and waist circumference for diabetic screening in women with a history of gestational diabetes. (24099446)
2013
16
Sudden fetal death in a patient with intrahepatic cholestasis of pregnancy complicated with gestational diabetes mellitus. (22886327)
2013
17
Maternal, umbilical arterial and umbilical venous 25-hydroxyvitamin D and adipocytokine concentrations in pregnancies with and without gestational diabetes. (24102192)
2013
18
Risk Factors That can Predict Antenatal Insulin Need in Gestational Diabetes. (23976911)
2013
19
Response to Lie et al. Preventing Type 2 diabetes after gestational diabetes: women's experiences and implications for diabetes prevention interventions. (23952364)
2013
20
Prevalence of gestational diabetes mellitus in urban and rural Tanzania. (24367971)
2013
21
Response to Comment on: Black et al. The relative contribution of prepregnancy overweight and obesity, gestational weight gain, and IADPSG-defined gestational diabetes mellitus to fetal overgrowth. Diabetes Care 2013;36:56-62. (23881981)
2013
22
Preventing type 2 diabetes after gestational diabetes: women's experiences and implications for diabetes prevention interventions. (23534548)
2013
23
Heterogeneity of pregnancy outcomes and risk of LGA neonates in Caucasian females according to IADPSG criteria for gestational diabetes mellitus. (23182459)
2013
24
Comparison of the world health organization and the International association of diabetes and pregnancy study groups criteria in diagnosing gestational diabetes mellitus in South Indians. (24083175)
2013
25
Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus. (23850897)
2013
26
Gestational diabetes: update of screening strategy and diagnostic criteria. (24136163)
2013
27
Gestational diabetes needs to be managed. (23919699)
2013
28
Physician care patterns and adherence to postpartum glucose testing after gestational diabetes mellitus in Oregon. (23071709)
2012
29
An infant born to a mother with gestational diabetes presenting with 49,XXXXY syndrome and renal agenesis-a case report. (23032147)
2012
30
Effectiveness of gestational diabetes treatment: a systematic review with quality of evidence assessment. (23031412)
2012
31
Fetal insulin and IGF-II contribute to gestational diabetes mellitus (GDM)-associated up-regulation of membrane-type matrix metalloproteinase 1 (MT1-MMP) in the human feto-placental endothelium. (22893718)
2012
32
Prolactin and lactation as modifiers of diabetes risk in gestational diabetes. (21823053)
2011
33
Dysregulation of placental endothelial lipase in obese women with gestational diabetes mellitus. (21852675)
2011
34
A polymorphism in the retinol binding protein 4 gene is not associated with gestational diabetes mellitus in several different ethnic groups. (21886308)
2011
35
Optimal glycemic control, pre-eclampsia, and gestational hypertension in women with type 1 diabetes in the diabetes and pre-eclampsia intervention trial. (21636798)
2011
36
The role of visfatin in the pathogenesis of gestational diabetes mellitus. (20220292)
2011
37
Third trimester plasma adiponectin and leptin in gestational diabetes and normal pregnancies. (21632143)
2011
38
Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus. (19682537)
2010
39
Relationship between the inhibition of NF-kappaB and insulin resistance in uterrus of rats with gestational diabetes mellitus]. (20230686)
2010
40
Detection of pregnancies with high risk of fetal macrosomia among women with gestational diabetes mellitus. (18728914)
2008
41
Proliferative diabetic retinopathy inauguring gestational diabetes]. (18514611)
2008
42
Mild gestational diabetes in pregnancy and the adipoinsular axis in babies born to mothers in the ACHOIS randomised controlled trial. (17430602)
2007
43
Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes. (17305786)
2007
44
GCK and HNF1alpha mutations and polymorphisms in Polish women with gestational diabetes. (16963153)
2007
45
Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. (16026366)
2005
46
Clinical study of maternal serum leptin levels as a predictor of gestational diabetes mellitus and gestational impaired glucose tolerance]. (15840309)
2005
47
Gestational diabetes mellitus is associated with increased C-reactive protein concentrations in the third but not second trimester. (16313251)
2005
48
Calpain-10 haplotype combination and association with gestational diabetes mellitus. (15172858)
2004
49
Maternal metabolic control and perinatal outcome in women with gestational diabetes treated with regular or lispro insulin: comparison with non-diabetic pregnant women. (14557006)
2003
50
Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus. (11772903)
2002

Genetic Variations for Gestational Diabetes

Expression for genes affiliated with Gestational Diabetes

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gestational Diabetes

Search GEO for disease gene expression data for Gestational Diabetes.

Pathways for genes affiliated with Gestational Diabetes

Sources:
38NCBI BioSystems Database, 53R&D Systems, 30KEGG, 50PharmGKB
See all sources

Pathways related to Gestational Diabetes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8ADIPOQ, LEP, INS, NAMPT, RETN, FOXC2
2
Hide members
10.7RBP4, RETN, NAMPT, ADIPOQ
3
Hide members
10.6ADIPOQ, INS, GCK

Compounds for genes affiliated with Gestational Diabetes

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Gestational Diabetes according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1glucose4511.6ADIPOQ, GCK, CAPN10, APLN, FOXC2, RBP4
2lipid4511.5GCK, CAPN10, FOXC2, RBP4, ATHS, RETN
3cholesterol45 29 11 2414.4RBP4, APLN, CAPN10, GCK, ATHS, RETN
4fatty acid4511.3GCK, RBP4, RETN, NAMPT, INS, LEP
5creatinine4511.3GCK, RBP4, RETN, NAMPT, INS, LEP
6metformin45 50 1113.2GCK, RETN, NAMPT, INS, LEP, ADIPOQ
7dexamethasone45 50 29 1114.2GCK, RBP4, RETN, NAMPT, INS, LEP
8pioglitazone45 50 29 1114.2RBP4, RETN, NAMPT, INS, LEP, ADIPOQ
9rosiglitazone45 50 29 11 2415.2RBP4, RETN, NAMPT, INS, LEP, ADIPOQ
10arginine4511.2GCK, CAPN10, IGKV2D-29, INS, LEP, LNPEP
11ly2940024511.2GCK, APLN, RETN, INS, LEP, ADIPOQ
12glycogen45 2412.2GCK, CAPN10, RETN, INS, LNPEP, ADIPOQ
13alanine4511.2GCK, APLN, RBP4, RETN, INS, LNPEP
14c-peptide4511.2GCK, RETN, INS, LEP, ADIPOQ
15thyroxine45 2412.2RBP4, RETN, INS, LEP, ADIPOQ
16nash4511.1RETN, INS, LEP, ADIPOQ
17thiazolidinedione4511.1ADIPOQ, LEP, INS, RETN
18aicar45 11 2413.1ADIPOQ, LEP, INS, GCK
198-isoprostane4511.1RETN, INS, LEP, ADIPOQ
20dehydroepiandrosterone sulfate4511.1RBP4, INS, LEP, ADIPOQ
21progesterone45 60 29 11 2415.1GCK, RBP4, RETN, LEP, FSTL3, LNPEP
22fenofibrate45 50 1113.1RETN, INS, LEP, ADIPOQ
23dhea4511.1RETN, INS, LEP, ADIPOQ
24triacylglycerol4511.1ADIPOQ, LEP, INS, RBP4
25fibrinogen4511.1RETN, NAMPT, INS, LEP, ADIPOQ
26androstenedione45 2412.1RBP4, INS, LEP, ADIPOQ
27sibutramine45 1112.0ADIPOQ, LEP, INS
28p0024511.0RBP4, RETN, LEP, ADIPOQ
29acipimox45 2912.0INS, LEP, ADIPOQ
30phosphatidylinositol4511.0APLN, RETN, NAMPT, INS, LEP, ADIPOQ
31glimepiride45 50 1113.0ADIPOQ, INS, RETN
32carbohydrates4511.0ADIPOQ, LEP, INS, GCK
33telmisartan45 29 1113.0ADIPOQ, LEP, INS
34sulfonylurea4511.0GCK, INS, ADIPOQ
35orlistat45 60 1113.0ADIPOQ, LEP, INS
36glycerol45 11 2412.9GCK, INS, LEP, ADIPOQ
37niacin45 1111.9NAMPT, INS, ADIPOQ
3825-hydroxyvitamin d4510.9CYP2R1, LEP, ADIPOQ
3911beta-hydroxysteroid4510.9RETN, LEP, ADIPOQ
40chromium picolinate4510.9INS, GCK
41streptozotocin4510.9ADIPOQ, INS, GCK
42vitamin a45 11 2412.9RBP4, RETN, LEP, ADIPOQ
43glycerol 3-phosphate45 2411.8ADIPOQ, LEP, GCK
44olanzapine50 45 29 11 2414.8ADIPOQ, LEP, INS
45glibenclamide45 29 50 6013.7INS, LEP, ADIPOQ
46exenatide45 1111.7LEP, INS
472-deoxyglucose45 1111.6ADIPOQ, INS, GCK
482-arachidonoylglycerol45 2911.6ADIPOQ, LEP
49preproinsulin4510.5GCK, INS
50atazanavir45 50 1112.3INS, ADIPOQ

GO Terms for genes affiliated with Gestational Diabetes

Sources:
16Gene Ontology
See all sources

Cellular components related to Gestational Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.9RBP4, RETN, INS, LEP, FSTL3, LNPEP
2extracellular spaceGO:00561510.5ADIPOQ, APLN, RBP4, RETN, INS, LEP

Biological processes related to Gestational Diabetes according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1glucose homeostasisGO:04259311.0ADIPOQ, INS, MTNR1B, RBP4, GCK
2regulation of insulin secretionGO:05079611.0GCK, MTNR1B, INS, LEP
3negative regulation of gluconeogenesisGO:04572110.9GCK, INS, ADIPOQ
4positive regulation of glucose importGO:04632610.9ADIPOQ, INS, CAPN10
5positive regulation of insulin secretionGO:03202410.9GCK, CAPN10, RBP4
6response to insulin stimulusGO:03286810.8RBP4, RETN, LEP
7cellular response to insulin stimulusGO:03286910.8ADIPOQ, CAPN10, GCK
8negative regulation of vasoconstrictionGO:04590610.8LEP, APLN
9positive regulation of insulin receptor signaling pathwayGO:04662810.7LEP, INS
10positive regulation of glycolysisGO:04582110.7INS, GCK
11positive regulation of cellular protein metabolic processGO:03227010.6INS, ADIPOQ
12positive regulation of glycogen biosynthetic processGO:04572510.6INS, GCK
13adipose tissue developmentGO:06061210.6LEP, NAMPT
14glucose metabolic processGO:00600610.5INS, LEP, ADIPOQ
15embryonic heart tube developmentGO:03505010.3HHEX, FOXC2

Molecular functions related to Gestational Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7ADIPOQ, LEP, INS, RETN, APLN

Products for genes affiliated with Gestational Diabetes

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gestational Diabetes

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet