Sources: 12Gene Ontology See all sources |
Cellular components related to gestational diabetes according to GeneDecks: (show all 14)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | clathrin-coated endocytic vesicle membrane | GO:030669 | 10.1 | HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, APOB | | 2 | transport vesicle membrane | GO:030658 | 10.1 | SLC30A8, HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1 | | 3 | ER to Golgi transport vesicle membrane | GO:012507 | 10.1 | SREBF2, SREBF1, HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1 | | 4 | MHC class II protein complex | GO:042613 | 10.1 | HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1 | | 5 | trans-Golgi network membrane | GO:032588 | 10.1 | HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB5 | | 6 | integral to lumenal side of endoplasmic reticulum membrane | GO:071556 | 10.0 | HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-A | | 7 | secretory granule | GO:030141 | 9.7 | SLC30A8, OXT, TF, PLAT, GHRL, GIP | | 8 | integral to plasma membrane | GO:005887 | 9.3 | HLA-DRB3, TPO, TNF, PTPRN, PDGFRB, HFE | | 9 | external side of plasma membrane | GO:009897 | 8.9 | SLC2A4, ACE, TNF, HLA-DRB5, HLA-DRB3, HLA-DRB1 | | 10 | cell surface | GO:009986 | 8.7 | TNF, PLAT, PDGFA, PDGFB, TGFB1, TPO | | 11 | platelet alpha granule lumen | GO:031093 | 8.6 | TGFB1, PDGFB, PDGFA, ALB, IGF1, SERPINE1 | | 12 | plasma membrane | GO:005886 | 7.4 | ABCC8, PDGFRB, TNF, TPO, HLA-DRB5, HLA-DRB3 | | 13 | extracellular region | GO:005576 | 4.1 | GAST, RETN, INS, IL18, IL1B, IL6 | | 14 | extracellular space | GO:005615 | 3.8 | PCSK1, INS, IL10, IL18, IL1B, IL6 |
Biological processes related to gestational diabetes according to GeneDecks: (show top 50)
(show all 103)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | positive regulation of insulin secretion | GO:032024 | 10.9 | SLC30A8, GLUD1, TCF7L2, GCK, RBP4, GHRL | | 2 | glucose homeostasis | GO:042593 | 10.8 | INSR, ADIPOQ, HNF1A, WFS1, INS, IRS1 | | 3 | endocrine pancreas development | GO:031018 | 10.8 | IL6, GCK, INS, NEUROD1, PDX1, GIP | | 4 | energy reserve metabolic process | GO:006112 | 10.8 | ADRB3, ABCC8, GIP, FASN, INS, LEPR | | 5 | brown fat cell differentiation | GO:050873 | 10.7 | ADRB3, ADIPOQ, PPARG, PPARGC1A, FABP4, CEBPA | | 6 | glucose metabolic process | GO:006006 | 10.7 | LEP, INS, APOD, IGF2, GHRL, TNF | | 7 | acute-phase response | GO:006953 | 10.5 | AHSG, CRP, MBL2, IL6, INS, CEBPA | | 8 | cellular response to insulin stimulus | GO:032869 | 10.4 | ADIPOQ, GCK, SLC2A4, AHSG, PPARG, GHSR | | 9 | cholesterol metabolic process | GO:008203 | 10.4 | APOB, CEBPA, LEPR, LEP, SREBF1, SREBF2 | | 10 | positive regulation of glucose import | GO:046326 | 10.4 | PIK3R1, IGF1, INS, CAPN10, INSR, ADIPOQ | | 11 | positive regulation of glycogen biosynthetic process | GO:045725 | 10.3 | IGF2, IGF1, GCK, IRS1, INS, INSR | | 12 | insulin secretion | GO:030073 | 10.2 | LEP, HNF1A, CYB5R4, PDX1, SLC30A8, NEUROD1 | | 13 | response to nutrient | GO:007584 | 10.2 | PPARG, ADIPOQ, DDIT3, SST, TNFRSF11B, HMGCR | | 14 | response to ethanol | GO:045471 | 10.2 | CCL2, ADIPOQ, SOD1, SLC2A4, ICAM1, RBP4 | | 15 | regulation of insulin secretion | GO:050796 | 10.2 | TNF, IL1B, HNF4A, ABCC8, NOS2, GIP | | 16 | positive regulation of phosphatidylinositol 3-kinase cascade | GO:014068 | 10.1 | IGF1, INS, CAT, PPARD, PDGFA, PDGFB | | 17 | immunoglobulin production involved in immunoglobulin mediated immune response | GO:002381 | 10.1 | HLA-DRB5, HLA-DRB3, HLA-DRB1, HLA-DQB1 | | 18 | response to glucose stimulus | GO:009749 | 10.1 | PTPRN, SLC30A8, ADIPOQ, NEUROD1, HNF4A, TGFB1 | | 19 | positive regulation of MAPK cascade | GO:043410 | 10.1 | LEP, INS, PDGFA, ADRB3, AGT, PDGFB | | 20 | response to testosterone stimulus | GO:033574 | 10.1 | EPO, EDN1, INSR, MSTN, BGLAP, UTS2 | | 21 | response to estrogen stimulus | GO:043627 | 9.9 | PTPRN, MSTN, GHRL, FAS, PPARG, EPO | | 22 | positive regulation of peptidyl-tyrosine phosphorylation | GO:050731 | 9.8 | IGF1, GHR, PDGFB, AGT, ADIPOQ, IL6 | | 23 | response to heat | GO:009408 | 9.7 | SOD1, CPB2, MICA, CCL2, MSTN, IL1B | | 24 | lipid metabolic process | GO:006629 | 9.7 | APOB, SREBF2, SREBF1, HNF4A, ALB, FABP4 | | 25 | response to activity | GO:014823 | 9.6 | CCL2, TNF, BGLAP, INSR, IL10, OXT | | 26 | positive regulation of nitric oxide biosynthetic process | GO:045429 | 9.5 | EDN1, ICAM1, TNF, IL1B, INSR, INS | | 27 | positive regulation of mitosis | GO:045840 | 9.4 | INS, INSR, EDN1, PDGFRB, PDGFB, TNF | | 28 | negative regulation of apoptotic process | GO:043066 | 9.4 | NEUROD1, TNF, GHRL, CAT, EPO, IL6 | | 29 | organ regeneration | GO:031100 | 9.4 | AHSG, PPARG, CEBPA, CCL2, MED1, AFP | | 30 | cell-cell signaling | GO:007267 | 9.3 | LNPEP, NAMPT, PCSK1, IAPP, IL10, IL18 | | 31 | positive regulation of MAP kinase activity | GO:043406 | 9.3 | HTR2A, PDGFA, PDGFB, PDGFRB, EDN1, TGFB1 | | 32 | positive regulation of protein kinase B signaling cascade | GO:051897 | 9.2 | IGF1, IGF2, INSR, TNF, PDGFA, INS | | 33 | small molecule metabolic process | GO:044281 | 9.2 | APOA1, PCSK1, GCK, NAMPT, KCNJ11, UCP2 | | 34 | cytokine-mediated signaling pathway | GO:019221 | 9.1 | HLA-DRB3, CCL2, PTPRN, HLA-DRB5, HLA-DQB1, ICAM1 | | 35 | cellular response to organic cyclic compound | GO:071407 | 9.1 | IL18, IL1B, CCL2, TNF, PPARG, CEBPA | | 36 | positive regulation of NF-kappaB transcription factor activity | GO:051092 | 8.6 | AGER, INS, TGFB1, AGT, IL1B, IL6 | | 37 | negative regulation of transcription from RNA polymerase II promoter | GO:000122 | 8.6 | TCF7L2, SREBF2, PPARD, PPARG, PPARA, NFKB1 | | 38 | response to glucocorticoid stimulus | GO:051384 | 8.5 | MSTN, CEBPA, BGLAP, SERPINE1, GHR, INSR | | 39 | positive regulation of cell proliferation | GO:008284 | 8.5 | IL6, INSR, INS, IRS1, LEP, NAMPT | | 40 | platelet degranulation | GO:002576 | 8.4 | SERPINE1, VWF, SERPINA1, APOA1, IGF1, ALB | | 41 | aging | GO:007568 | 8.3 | DDIT3, HMGCR, CCL2, APOD, IL1B, FAS | | 42 | positive regulation of transcription from RNA polymerase II promoter | GO:045944 | 8.1 | IL6, IGF1, HNF1A, HNF4A, TNF, IL1B | | 43 | anti-apoptosis | GO:006916 | 8.1 | IL10, SERPINB2, IL1B, FAS, CCL2, IGF1 | | 44 | platelet activation | GO:030168 | 8.0 | IL6, SERPINE1, SERPINA1, VWF, PIK3R1, APOA1 | | 45 | response to drug | GO:042493 | 7.9 | TNFRSF11B, EDN1, LTA, PDGFB, PPARG, SST | | 46 | response to hypoxia | GO:001666 | 7.7 | UTS2, LEP, IL18, SERPINA1, IL1B, CRP | | 47 | inflammatory response | GO:006954 | 7.6 | SELE, MIF, IL10, IL6, ORM1, TGFB1 | | 48 | negative regulation of cell proliferation | GO:008285 | 7.6 | TNF, CYP27B1, SST, PDX1, AGT, TGFB1 | | 49 | blood coagulation | GO:007596 | 7.6 | PLAT, PDGFA, SERPINC1, PIK3R1, VWF, PDGFB | | 50 | positive regulation of transcription, DNA-dependent | GO:045893 | 7.4 | HNF4A, HMGA1, TNF, PPARGC1A, PPARG, PPARA |
Molecular functions related to gestational diabetes according to GeneDecks: (show all 15)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | insulin binding | GO:043559 | 10.5 | IDE, INSR, PCSK1, PIK3R1 | | 2 | transcription regulatory region DNA binding | GO:044212 | 10.3 | HHEX, TCF7L2, NFKB1, PPARG, TNF, HNF4A | | 3 | protease binding | GO:002020 | 10.1 | TNF, INS, SERPINE1, SERPINA1, SERPINC1 | | 4 | insulin-like growth factor receptor binding | GO:005159 | 10.0 | IGF1, IGF2, INSR, INS, IRS1, PIK3R1 | | 5 | MHC class II receptor activity | GO:032395 | 10.0 | HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1 | | 6 | insulin receptor binding | GO:005158 | 9.9 | IGF1, IGF2, ENPP1, INS, IRS1, PIK3R1 | | 7 | receptor binding | GO:005102 | 9.8 | CAT, HNF4A, HLA-A, NOS2, PDGFRB, LTA | | 8 | transcription factor binding | GO:008134 | 9.7 | HHEX, NEUROD1, TCF7L2, PPARGC1A, DDIT3, HMGA1 | | 9 | eukaryotic cell surface binding | GO:043499 | 9.4 | EPO, ADIPOQ, TGFB1, PDGFB, PDGFA, MBL2 | | 10 | hormone activity | GO:005179 | 9.3 | RETN, SST, EDN1, AGT, TTR, PRL | | 11 | cytokine activity | GO:005125 | 9.1 | ADIPOQ, EDN1, LTA, TNFRSF11B, TNF, IL6 | | 12 | drug binding | GO:008144 | 9.0 | PPARD, PPARA, PPARG, ALB, HTR2A, ACE | | 13 | protein homodimerization activity | GO:042803 | 8.9 | PDGFA, PDGFB, SHBG, TGFB1, SOD1, SLC30A8 | | 14 | growth factor activity | GO:008083 | 8.1 | TGFB1, AGT, PDGFB, PDGFA, IGF1, IGF2 | | 15 | protein binding | GO:005515 | 3.6 | PPARG, PPARA, CRP, PLAT, NOS2, NFKB1 |
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