GDM
MCID: GST033
MIFTS: 57

Gestational Diabetes (GDM) malady

Categories: Metabolic diseases

Aliases & Classifications for Gestational Diabetes

Aliases & Descriptions for Gestational Diabetes:

Name: Gestational Diabetes 12 14 69
Gestational Diabetes Mellitus 12 29 14
Gdm 12 45
Maternal Gestational Diabetes Mellitus 12
Diabetes Mellitus, Gestational 13
Diabetes, Gestational 42
Diabetes Gestational 52

Classifications:



External Ids:

Disease Ontology 12 DOID:11714
ICD10 33 O24.4
MeSH 42 D016640
NCIt 47 C34942
UMLS 69 C0085207

Summaries for Gestational Diabetes

MalaCards based summary : Gestational Diabetes, also known as gestational diabetes mellitus, is related to gestational diabetes insipidus and mody, type ii, and has symptoms including hyperemesis gravidarum, pelvic pain and morning sickness. An important gene associated with Gestational Diabetes is INS (Insulin), and among its related pathways/superpathways are Developmental Biology and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Metformin and Glyburide have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and endothelial, and related phenotypes are adipose tissue and homeostasis/metabolism

Wikipedia : 71 Gestational diabetes also known as gestational diabetes mellitus (GDM), is a condition in which a woman... more...

Related Diseases for Gestational Diabetes

Diseases related to Gestational Diabetes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Related Disease Score Top Affiliating Genes
1 gestational diabetes insipidus 12.0
2 mody, type ii 11.0
3 diabetes mellitus, transient neonatal, 3 10.8
4 diabetes mellitus, insulin-dependent 10.8
5 obesity 10.4
6 intellectual disability-developmental delay-contractures syndrome 10.3 INS INSR
7 acrocephalopolydactyly 10.2 ADIPOQ LEP RETN
8 fetal warfarin syndrome 10.2 INS INSR LEP
9 mucinoses 10.2 ADIPOQ LEP RETN
10 hyperinsulinemic hypoglycemia, familial, 5 10.2 INS INSR IRS1
11 diabetic cataract 10.2 GCK INS INSR
12 mosaic trisomy 13 10.2 GCK HNF1A INS
13 limb ischemia 10.2 ADIPOQ INS LEP
14 lipomatosis 10.2 ADIPOQ INS LEP RBP4
15 epidural spinal canal meningioma 10.2 INS LEP SHBG
16 hyperlipoproteinemia type iv 10.2 ADIPOQ INS LEP TCF7L2
17 cortical blindness mental retardation polydactyly 10.2 ADIPOQ LEP RETN
18 diabetic encephalopathy 10.2 ADIPOQ INS LEP
19 not otherwise specified 3-mga-uria type 10.2 ADIPOQ INS LEP RETN
20 malignant perineurioma 10.2 ADIPOQ LEP NAMPT RETN
21 thymus clear cell carcinoma 10.2 ADIPOQ INS LEP RETN
22 glucose intolerance 10.2
23 fetal macrosomia 10.2
24 pelvic muscle wasting 10.2 INS INSR SHBG
25 endotheliitis 10.1
26 exophthalmic ophthalmoplegia 10.1 ADIPOQ LEP PAPPA
27 autosomal recessive congenital ichthyosis 10.1 INS LEP SLC2A4
28 glomangiomyoma 10.1 INS LEP SHBG
29 leg dermatosis 10.1 ADIPOQ INS INSR LEP SHBG
30 congenital stationary night blindness 10.1 GCK HNF1A INS IRS1
31 exostosis 10.1 GCK INS INSR LEP SHBG
32 pericarditis 10.1 ADIPOQ INS NAMPT RETN
33 mucopolysaccharidosis iii 10.0 ADIPOQ ADRB3 INS LEP RETN
34 eclampsia 10.0
35 diabetes insipidus 10.0
36 primary biliary cirrhosis 10.0 INS INSR IRS1 LEP SHBG
37 chronic tic disorder 10.0 ADIPOQ LEP PAPPA
38 pre-eclampsia 10.0
39 ischemic heart disease 10.0 GCK INS PTPRN
40 hyperglycemia 10.0
41 polycystic ovary syndrome 10.0
42 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.0 ADIPOQ LEP RETN
43 cataract 20, multiple types 9.9 ADIPOQ INS LEP RETN SLC2A4
44 hypertension, essential 9.9 ADIPOQ ADRB3 INS INSR LEP RETN
45 brain stem glioma 9.9 ADIPOQ GCK HNF1A INS INSR IRS1
46 neurogenic arthropathy 9.9 ADIPOQ GCK INS IRS1 LEP SLC2A4
47 pancreatitis 9.9
48 thyroiditis 9.8
49 periodontitis 9.8
50 hyperinsulinism 9.7

Graphical network of the top 20 diseases related to Gestational Diabetes:



Diseases related to Gestational Diabetes

Symptoms & Phenotypes for Gestational Diabetes

UMLS symptoms related to Gestational Diabetes:


hyperemesis gravidarum, pelvic pain, morning sickness

MGI Mouse Phenotypes related to Gestational Diabetes:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 10.32 INS INSR IRS1 IRS2 LEP RETN
2 homeostasis/metabolism MP:0005376 10.32 ADIPOQ ADIPOR1 ADRB3 GCK HNF1A INS
3 endocrine/exocrine gland MP:0005379 10.28 ADIPOQ ADRB3 GCK HNF1A INS INSR
4 growth/size/body region MP:0005378 10.28 ADIPOQ ADIPOR1 ADRB3 GCK HNF1A INS
5 behavior/neurological MP:0005386 10.24 IRS2 LEP RBP4 SLC29A1 TCF7L2 ADIPOQ
6 cellular MP:0005384 10.2 ADIPOQ ADIPOR1 HNF1A INS INSR IRS1
7 cardiovascular system MP:0005385 10.13 ADIPOQ INS INSR IRS1 IRS2 LEP
8 liver/biliary system MP:0005370 10.03 ADIPOR1 GCK HNF1A INS INSR IRS1
9 immune system MP:0005387 10.02 ADIPOQ INS INSR IRS1 IRS2 LEP
10 muscle MP:0005369 9.9 INS INSR IRS1 IRS2 LEP RBP4
11 renal/urinary system MP:0005367 9.5 INS INSR IRS2 LEP ADIPOQ GCK
12 skeleton MP:0005390 9.28 ADIPOQ ADIPOR1 HNF1A INS IRS1 LEP

Drugs & Therapeutics for Gestational Diabetes

Drugs for Gestational Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 14219 4091
2
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2 10238-21-8 3488
3
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
4
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Insulin Lispro Approved Phase 4,Phase 2 133107-64-9
7
Zinc Approved Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
8
Insulin Aspart Approved Phase 4,Phase 3,Phase 2 116094-23-6 16132418
9
Copper Approved Phase 4 15158-11-9, 7440-50-8 27099
10
Levonorgestrel Approved, Investigational Phase 4,Phase 2 797-63-7, 17489-40-6 13109
11
Liraglutide Approved Phase 4,Phase 3 204656-20-2
12
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
13
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
15
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 58-05-9 54575, 6560146 143
16
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 67-97-0 6221 10883523 5280795
17
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
18
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
19
Resveratrol Experimental, Investigational Phase 4 501-36-0, 955365-80-7 24856436 445154
20 Analgesics Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Anti-Inflammatory Agents Phase 4
23 Anti-Inflammatory Agents, Non-Steroidal Phase 4
24 Antineoplastic Agents, Phytogenic Phase 4
25 Antioxidants Phase 4,Phase 2,Phase 3
26 Antirheumatic Agents Phase 4
27 Hypoglycemic Agents Phase 4,Phase 2,Phase 3,Phase 1
28 insulin Phase 4,Phase 2,Phase 3,Phase 1
29 Insulin, Globin Zinc Phase 4,Phase 2,Phase 3,Phase 1
30 Peripheral Nervous System Agents Phase 4
31 Platelet Aggregation Inhibitors Phase 4
32 Protective Agents Phase 4
33 Hematinics Phase 4,Phase 2,Phase 3
34 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
35 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
36 Vitamin B Complex Phase 4,Phase 2,Phase 3
37 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
38 Androgen Antagonists Phase 4
39 Androgens Phase 4
40 Contraceptive Agents Phase 4
41 Contraceptive Agents, Male Phase 4
42
Cyproterone Phase 4 2098-66-0 5284537
43 Cyproterone acetate, ethinyl estradiol drug combination Phase 4
44 Estradiol 17 beta-cypionate Phase 4
45 Estradiol 3-benzoate Phase 4
46 Estradiol valerate Phase 4 979-32-8
47 Hormone Antagonists Phase 4,Phase 3,Phase 2
48 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
50 Polyestradiol phosphate Phase 4

Interventional clinical trials:

(show top 50) (show all 471)
id Name Status NCT ID Phase
1 Can Resveratrol Improve Insulin Sensitivity and Preserve Beta Cell Function Following Gestational Diabetes? Unknown status NCT01997762 Phase 4
2 Prevention of Diabetes Mellitus Development in Women Who Had Already Experienced A Gestational Diabetes Unknown status NCT00265746 Phase 4
3 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4
4 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4
5 Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women Unknown status NCT01511835 Phase 4
6 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4
7 Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia Unknown status NCT01718340 Phase 4
8 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4
9 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4
10 Antioxidants in Gestational Diabetes Completed NCT02355197 Phase 4
11 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4
12 Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women Completed NCT01675310 Phase 4
13 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4
14 Humalog® Mix50/50(tm) as a Treatment for Gestational Diabetes Completed NCT01613807 Phase 4
15 Metformin Postpartum for GDM RCT for Reduced Weight Retention Completed NCT01280409 Phase 4
16 Postpartum Glucose Tolerance With Levonorgesterel IUD Use in Women With Recent Gestational Diabetes Completed NCT01022645 Phase 4
17 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4
18 Testing Ascensia Contour Glucometer for the Measurement of Blood Glucose Completed NCT00502359 Phase 4
19 Resistance Exercise Training During Pregnancy: a Randomized Controlled Trial Completed NCT00813657 Phase 4
20 DAME: Induction of Labor or Waiting for Suspicion Fetal Macrosomia Completed NCT00190320 Phase 4
21 Preventing Recurrent Gestational Diabetes With Metformin Recruiting NCT02394158 Phase 4
22 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Recruiting NCT02590016 Phase 4
23 Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM Recruiting NCT01856907 Phase 4
24 Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn Recruiting NCT02508844 Phase 4
25 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4
26 The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Pregnancy-induced Diabetes Active, not recruiting NCT01795248 Phase 4
27 Safety and Efficacy of Omnitrope® (rhGH) in Short Children Born Small for Gestational Age (SGA) Active, not recruiting NCT00537914 Phase 4
28 The Impact of Vitamin D Supplementation on Glucose Metabolism in Chinese Women With Former Gestational Diabetes Mellitus Enrolling by invitation NCT03138616 Phase 4
29 Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus Not yet recruiting NCT03029702 Phase 4
30 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Not yet recruiting NCT03078725 Phase 4
31 Probiotics in Newly Recognized Type 1 Diabetes Not yet recruiting NCT03032354 Phase 4
32 Exenatide Pregnancy Registry - Type 2 Diabetes in Pregnancy Terminated NCT00579150 Phase 4
33 Study of Growth-promoting and Metabolic Effects of Growth Hormone (rhGH) Terminated NCT00597480 Phase 4
34 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4
35 Pilot Study of Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes Withdrawn NCT00572689 Phase 4
36 Glycemic Profile in Women With Gestational Diabetes Treated With Glyburide Withdrawn NCT01947699 Phase 4
37 Insulin Pre-treatment for Steroid-associated Hyperglycemia in Pregnant Diabetic Patients Withdrawn NCT01875107 Phase 4
38 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3
39 Metformin for the Treatment of Diabetes in Pregnancy Unknown status NCT00414245 Phase 3
40 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3
41 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3
42 Diazoxide In the Management Of Hypoglycemic Neonates Unknown status NCT00994149 Phase 2, Phase 3
43 Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus Completed NCT01087866 Phase 2, Phase 3
44 Gestational Diabetes: Insulin or Oral Hypoglycemic Agents? Completed NCT01215331 Phase 3
45 A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS Completed NCT02080377 Phase 3
46 Safety and Efficacy of Insulin Aspart vs. Regular Human Insulin in Gestational Diabetes Completed NCT00065130 Phase 3
47 Efficacy of Behavioral Therapy and Exercise in Gestational Diabetes Mellitus (GDM) Completed NCT01506310 Phase 3
48 Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial Completed NCT01788527 Phase 3
49 MAIN STUDY: Low Glycaemic Index (GI) Diet in the Management of GDM SUB-STUDY: The Breast Milk Sub-Study Completed NCT01589757 Phase 2, Phase 3
50 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3

Search NIH Clinical Center for Gestational Diabetes

Cochrane evidence based reviews: diabetes, gestational

Genetic Tests for Gestational Diabetes

Genetic tests related to Gestational Diabetes:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Gestational 29

Anatomical Context for Gestational Diabetes

MalaCards organs/tissues related to Gestational Diabetes:

39
Placenta, Testes, Endothelial, Ovary, Skeletal Muscle, Adipocyte, Breast

Publications for Gestational Diabetes

Articles related to Gestational Diabetes:

(show top 50) (show all 1208)
id Title Authors Year
1
Diagnostic protocol for gestational diabetes mellitus (GDM) (IADPSG/ADA, 2011): influence on the occurrence of GDM and mild gestational hyperglycemia (MGH) and on the perinatal outcomes. ( 28053673 )
2017
2
CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes. ( 28079868 )
2017
3
Investigation of miRNA-binding site variants and risk of gestational diabetes mellitus in Chinese pregnant women. ( 28190110 )
2017
4
MTNR1A and MTNR1B gene polymorphisms in women with gestational diabetes. ( 28084098 )
2017
5
The Effects of Race and Ethnicity on the Risk of Large-for-Gestational-Age Newborns in Women Without Gestational Diabetes by Prepregnancy Body Mass Index Categories. ( 28092059 )
2017
6
Outcomes of twin pregnancies complicated by gestational diabetes: a meta-analysis of observational studies. ( 28079866 )
2017
7
DIFFERENTIAL EXPRESSION OF CORD BLOOD NEUROTROPHINS IN GESTATIONAL DIABETES: THE IMPACT OF FETAL GROWTH ABNORMALITIES. ( 28081639 )
2017
8
Prescribing exercise for prevention and treatment of gestational diabetes: review of suggested recommendations. ( 28084847 )
2017
9
Potential protective effect of lactation against incidence of type 2 diabetes in women with previous gestational diabetes mellitus : A systematic review and meta-analysis. ( 28072911 )
2017
10
Pregnancies After the Diagnosis of Mild Gestational Diabetes Mellitus and Risk of Cardiometabolic Disorders. ( 28079773 )
2017
11
Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes. ( 28363002 )
2017
12
Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. ( 28077460 )
2017
13
Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. ( 28081192 )
2017
14
The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus. ( 27334434 )
2017
15
Phytosterol nutritional supplement improves pregnancy and neonatal complications of gestational diabetes mellitus in a double-blind and placebo-controlled clinical study. ( 28091647 )
2017
16
Primary prevention of gestational diabetes mellitus through nutritional factors: a systematic review. ( 28086820 )
2017
17
The Virtual Office Visit for Women With Gestational Diabetes Mellitus. ( 28077459 )
2017
18
"It's a Very Big Burden on Me": Women's Experiences Using Insulin for Gestational Diabetes. ( 28092062 )
2017
19
Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development. ( 28072873 )
2017
20
Adipose Tissue Insulin Resistance in Gestational Diabetes. ( 28080219 )
2017
21
GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes. ( 28359772 )
2017
22
CCL2, CCL5, IL4 and IL15 Gene Polymorphisms in Women with Gestational Diabetes Mellitus. ( 27472286 )
2017
23
Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes. ( 27196053 )
2016
24
Pregnancy after oocyte donation in 45, X Turner syndrome women, complicated by gestational diabetes and polyhydramnios. Case report and mini-review of literature. ( 26942946 )
2016
25
Pregnancy urinary phthalate metabolite concentrations and gestational diabetes risk factors. ( 27649471 )
2016
26
Seasonal Changes in the Prevalence of Gestational Diabetes Mellitus. ( 27208334 )
2016
27
Extreme Elevation of Alkaline Phosphatase in a Pregnancy Complicated by Gestational Diabetes and Infant with Neonatal Alloimmune Thrombocytopenia. ( 27610256 )
2016
28
Effect of Regular Exercise Commenced in Early Pregnancy on the Incidence of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Randomized Controlled Trial. ( 27660125 )
2016
29
Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes. ( 27209463 )
2016
30
Erratum to: A proposal for the use of uniform diagnostic criteria for gestational diabetes in Europe: an opinion paper by the European Board & College of Obstetrics and Gynaecology (EBCOG). ( 27193913 )
2016
31
Association between the PPARI^ Pro12Ala polymorphism and risk of gestational diabetes mellitus: a meta-analysis. ( 27819738 )
2016
32
Gestational diabetes mellitus treatment reduces obesity-induced adverse pregnancy and neonatal outcomes: the St. Carlos gestational study. ( 28074143 )
2016
33
Exercise improves glycaemic control in women diagnosed with gestational diabetes mellitus: a systematic review. ( 27637772 )
2016
34
Adherence to the DASH and Mediterranean diets is associated with decreased risk for gestational diabetes mellitus. ( 27189908 )
2016
35
IADPSG and WHO 2013 Gestational Diabetes Mellitus Criteria Identify Obese Women With Marked Insulin Resistance in Early Pregnancy. ( 27208336 )
2016
36
Prediction of gestational diabetes mellitus by first trimester serum secreted frizzle-related protein-5 levels. ( 26100762 )
2016
37
Comment on Rudland et al. Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Mellitus Cohort: New Pregnancy Screening Criteria and Utility of HbA1c. Diabetes Care 2016;39:50-52. ( 26696667 )
2016
38
Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis. ( 26975349 )
2016
39
Quality of care from the perspective of women with gestational diabetes in China. ( 27198743 )
2016
40
Heart Disease, hypertension, gestational diabetes and pre-eclampsia/eclampsia in mothers with juvenile arthritis: A nested case-control study. ( 27111101 )
2016
41
Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta. ( 26875564 )
2016
42
Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects. ( 26584065 )
2016
43
Genetics of Gestational Diabetes Mellitus and Maternal Metabolism. ( 26803651 )
2016
44
Peptidome profiling of umbilical cord plasma associated with gestational diabetes-induced fetal macrosomia. ( 26945739 )
2016
45
Effect of GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms on susceptiblity to gestational diabetes mellitus. ( 27323114 )
2016
46
LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus. ( 26296941 )
2016
47
Can the management of blood sugar levels in gestational diabetes mellitus cases be an indicator of maternal and fetal outcomes? The results of a prospective cohort study from India. ( 27186155 )
2016
48
Risk factors for postpartum glucose intolerance in women with gestational diabetes mellitus. ( 27113701 )
2016
49
Antenatal oral glucose tolerance test in women with gestational diabetes mellitus: fasting plasma glucose is the best predictor of both large for-gestational-age newborns and postpartum glucose tolerance. ( 27652599 )
2016
50
Increased Maternal Serum Interleukin-6 Concentrations at 11 to 14 Weeks of Gestation in Low Risk Pregnancies Complicated with Gestational Diabetes Mellitus: Development of a Prediction Model. ( 25565094 )
2016

Variations for Gestational Diabetes

ClinVar genetic disease variations for Gestational Diabetes:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GCK NM_000162.3(GCK): c.544G> A (p.Val182Met) single nucleotide variant Pathogenic rs587780345 GRCh37 Chromosome 7, 44189603: 44189603
2 GCK NM_000162.3(GCK): c.706G> A (p.Glu236Lys) single nucleotide variant Pathogenic rs587780347 GRCh37 Chromosome 7, 44187406: 44187406

Expression for Gestational Diabetes

Search GEO for disease gene expression data for Gestational Diabetes.

Pathways for Gestational Diabetes

Pathways related to Gestational Diabetes according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 ADIPOQ GCK HNF1A INS IRS1 IRS2
2
Show member pathways
12.87 GCK HKDC1 INS INSR IRS1 IRS2
3
Show member pathways
12.81 ADRB3 INS INSR IRS1 IRS2
4
Show member pathways
12.73 INS INSR IRS1 IRS2 SLC2A4
5
Show member pathways
12.64 ADIPOQ INS INSR IRS1 IRS2 LEP
6
Show member pathways
12.48 INS INSR IRS1 IRS2 SLC2A4
7 12.47 ADIPOQ HNF1A INS INSR IRS1 IRS2
8
Show member pathways
12.43 GCK INS IRS1 IRS2 LEP
9
Show member pathways
12.39 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
10
Show member pathways
12.19 INS INSR IRS1 IRS2 LEP SLC2A4
11
Show member pathways
12.11 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
12
Show member pathways
12.06 INS INSR IRS1 IRS2 SLC2A4
13
Show member pathways
11.99 GCK HNF1A INS INSR
14
Show member pathways
11.93 INS INSR IRS1 IRS2 SLC2A4
15 11.85 ADIPOQ INS LEP SLC2A4
16
Show member pathways
11.82 GCK HNF1A INS
17 11.81 HKDC1 INS INSR
18 11.73 ADIPOQ HNF1A INS IRS1 IRS2 LEP
19 11.64 ADIPOQ ADIPOR1 IRS1 IRS2 LEP SLC2A4
20 11.62 INS INSR IRS1
21 11.56 ADRB3 INS INSR IRS1 IRS2
22 11.55 IRS1 IRS2 LEP SLC2A4
23 11.51 INS INSR IRS1 LEP
24 11.44 GCK HNF1A INS
25 11.42 INS INSR IRS1
26 11.34 INS INSR IRS1
27
Show member pathways
11.26 ADIPOQ GCK HKDC1 HNF1A INS INSR
28 11.21 INS INSR SLC2A4
29 10.98 ADIPOQ INSR IRS1 IRS2 LEP SLC2A4
30
Show member pathways
10.93 INSR IRS1 SLC2A4
31 10.85 INS SLC2A4

GO Terms for Gestational Diabetes

Cellular components related to Gestational Diabetes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin receptor complex GO:0005899 8.62 INSR IRS1

Biological processes related to Gestational Diabetes according to GeneCards Suite gene sharing:

(show all 38)
id Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.93 ADRB3 GCK HKDC1 INS INSR SLC2A4
2 response to ethanol GO:0045471 9.88 ADIPOQ LEP RBP4 SLC2A4
3 female pregnancy GO:0007565 9.84 LEP NAMPT PAPPA
4 positive regulation of MAPK cascade GO:0043410 9.84 ADRB3 INS INSR LEP
5 circadian rhythm GO:0007623 9.83 ADIPOQ LEP NAMPT
6 positive regulation of protein kinase B signaling GO:0051897 9.83 INS INSR LEP TCF7L2
7 insulin receptor signaling pathway GO:0008286 9.83 INS INSR IRS1 IRS2 NAMPT
8 regulation of insulin secretion GO:0050796 9.81 GCK HNF1A LEP
9 response to insulin GO:0032868 9.81 IRS1 LEP PTPRN RETN
10 response to glucose GO:0009749 9.8 ADIPOQ HNF1A IRS2 PTPRN TCF7L2
11 positive regulation of insulin secretion GO:0032024 9.78 GCK IRS2 RBP4 TCF7L2
12 glucose metabolic process GO:0006006 9.77 ADIPOQ GCK INS IRS2 LEP
13 glucose transport GO:0015758 9.76 GCK INS SLC2A4
14 brown fat cell differentiation GO:0050873 9.73 ADIPOQ ADRB3 SLC2A4
15 cellular response to insulin stimulus GO:0032869 9.73 ADIPOQ GCK INSR IRS1 IRS2 SLC2A4
16 insulin secretion GO:0030073 9.72 HNF1A LEP PTPRN
17 positive regulation of cellular protein metabolic process GO:0032270 9.68 ADIPOQ INS
18 cellular glucose homeostasis GO:0001678 9.67 GCK HKDC1
19 fatty acid oxidation GO:0019395 9.67 ADIPOQ ADIPOR1
20 energy reserve metabolic process GO:0006112 9.67 ADRB3 LEP
21 negative regulation of gluconeogenesis GO:0045721 9.67 ADIPOQ GCK INS
22 positive regulation of glycolytic process GO:0045821 9.66 INS INSR
23 glucose import GO:0046323 9.65 HNF1A SLC2A4
24 cellular response to leptin stimulus GO:0044320 9.65 GCK LEP
25 glucose 6-phosphate metabolic process GO:0051156 9.64 GCK HKDC1
26 positive regulation of fatty acid beta-oxidation GO:0032000 9.63 IRS1 IRS2
27 leptin-mediated signaling pathway GO:0033210 9.63 ADIPOR1 LEP
28 regulation of fatty acid biosynthetic process GO:0042304 9.62 ADIPOQ ADIPOR1
29 positive regulation of glucose metabolic process GO:0010907 9.62 IRS1 IRS2
30 positive regulation of insulin receptor signaling pathway GO:0046628 9.62 ADIPOR1 INS IRS1 LEP
31 adiponectin-activated signaling pathway GO:0033211 9.61 ADIPOQ ADIPOR1
32 positive regulation of respiratory burst GO:0060267 9.61 INS INSR
33 negative regulation of feeding behavior GO:2000252 9.6 INS RETN
34 positive regulation of developmental growth GO:0048639 9.59 INSR LEP
35 positive regulation of glucose import GO:0046326 9.55 ADIPOQ INS INSR IRS1 IRS2
36 glucose homeostasis GO:0042593 9.36 ADIPOQ ADIPOR1 GCK HNF1A INS INSR
37 positive regulation of glycogen biosynthetic process GO:0045725 9.35 GCK INS INSR IRS1 IRS2
38 positive regulation of cell proliferation GO:0008284 10.04 INS INSR IRS1 IRS2 LEP NAMPT

Molecular functions related to Gestational Diabetes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glucose binding GO:0005536 9.46 GCK HKDC1
2 hormone activity GO:0005179 9.46 ADIPOQ INS LEP RETN
3 hexokinase activity GO:0004396 9.43 GCK HKDC1
4 insulin receptor binding GO:0005158 9.43 INS IRS1 IRS2
5 glucokinase activity GO:0004340 9.4 GCK HKDC1
6 fructokinase activity GO:0008865 9.37 GCK HKDC1
7 mannokinase activity GO:0019158 9.32 GCK HKDC1
8 phosphatidylinositol 3-kinase binding GO:0043548 9.13 INSR IRS1 IRS2
9 insulin-like growth factor receptor binding GO:0005159 8.8 INS INSR IRS1

Sources for Gestational Diabetes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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