GDM
MCID: GST033
MIFTS: 62

Gestational Diabetes (GDM) malady

Genetic diseases (common) category
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Summaries for Gestational Diabetes

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Gestational diabetes (or gestational diabetes mellitus, GDM) is a condition in which women without... more...

MalaCards: Gestational Diabetes, also known as diabetes mellitus, gestational, is related to diabetes mellitus and insulin resistance. An important gene associated with Gestational Diabetes is GCK (glucokinase (hexokinase 4)), and among its related pathways are Insulin-mediated glucose transport and IL-9 Signaling Pathways. The compounds chromium picolinate and preproinsulin have been mentioned in the context of this disorder. Affiliated tissues include testes, placenta and ovary, and related mouse phenotypes are adipose tissue and liver/biliary system.

Description from OMIM:47 125851

Aliases & Classifications for Gestational Diabetes

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8Disease Ontology, 10DISEASES, 62UMLS, 39NCBI Bookshelf, 9diseasecard, 22GTR, 47OMIM, 45Novoseek, 35MeSH, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

gestational diabetes 8 10 62
diabetes mellitus, gestational 9 22 47
gdm 8 39
maternal gestational diabetes mellitus 8
gestational diabetes mellitus 8
diabetes gestational 45


External Ids:

Disease Ontology8 DOID:11714
MeSH35 D016640
NCIt40 C34942

Related Diseases for Gestational Diabetes

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17GeneCards, 18GeneDecks
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Diseases related to Gestational Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus31.6KCNJ11, INS, NAMPT, FOXC2, MTNR1B, CAPN10
2insulin resistance31.0INS, NAMPT, FOXC2, CAPN10, GCK, RBP4
3obesity31.0KCNJ11, INS, NAMPT, FOXC2, CAPN10, GCK
4glucose intolerance30.8INS, CAPN10, GCK, RBP4
5polycystic ovary syndrome30.7INS, CAPN10
6hyperglycemia30.6KCNJ11, INS, NAMPT, GCK
7hyperinsulinism30.4GCK, INS, KCNJ11
8atherosclerosis30.2ATHS, INS, NAMPT, CAPN10, RBP4
9hypoglycemia30.2KCNJ11, INS, GCK
10hyperinsulinemic hypoglycemia30.0KCNJ11, INS, GCK
11maturity-onset diabetes of the young30.0GCK, INS, KCNJ11
12hypertriglyceridemia30.0FOXC2, INS, ATHS
13type 2 diabetes mellitus30.0LNPEP, KCNJ11, INS, NAMPT, CAPN10, GCK
14infertility30.0CAPN10, INS, LNPEP
15fetal macrosomia10.6
16gestational diabetes insipidus10.5
17eclampsia10.5
18hypertension10.5
19diabetes insipidus10.5
20pre-eclampsia10.5
21endotheliitis10.5
22periodontitis10.3
23thyroiditis10.3
24pancreatitis10.2
25blindness10.2
26diabetic ketoacidosis10.2
27acanthosis nigricans10.2
28cryptorchidism10.2
29cholestasis10.2
30maturity-onset diabetes of the young, type 210.2
31familial hyperinsulinism10.1KCNJ11, GCK
32permanent neonatal diabetes mellitus10.1INS, GCK
33hyperammonemia multi-gene panels10.0GCK, KCNJ11
34hyperuricemia10.0INS, GCK
35fatty liver disease10.0RBP4, INS
36type 1 diabetes mellitus10.0INS, GCK
37neonatal diabetes mellitus10.0GCK, INS, KCNJ11
38coronary artery disease10.0NAMPT, INS, ATHS
39insulinoma10.0KCNJ11, INS, GCK
40deficiency anemia10.0
41intrahepatic cholestasis10.0
42wolff-parkinson-white syndrome10.0
43acute pancreatitis10.0
44obstructive sleep apnea10.0
45hypospadias10.0
46iron deficiency anemia10.0
47central pontine myelinolysis10.0
48potter's syndrome10.0
49holoprosencephaly10.0
50renal agenesis10.0

Graphical network of the top 20 diseases related to Gestational Diabetes:



Diseases related to gestational diabetes

Symptoms for Gestational Diabetes

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47OMIM
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Clinical features from OMIM:

125851

Drugs & Therapeutics for Gestational Diabetes

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Gestational Diabetes

Search NIH Clinical Center for Gestational Diabetes

Genetic Tests for Gestational Diabetes

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22GTR
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Genetic tests related to Gestational Diabetes:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Gestational22

Anatomical Context for Gestational Diabetes

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33MalaCards
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MalaCards organs/tissues related to Gestational Diabetes:

33
Testes, Placenta, Ovary, Endothelial, Skeletal muscle, Thyroid, Breast, Adipocyte, Monocytes, Smooth muscle, Heart, T cells, B cells, Liver, Skin

Animal Models for Gestational Diabetes or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Gestational Diabetes:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.2CAPN10, FOXC2, INS, KCNJ11
2MP:00053708.8INS, FOXC2, CAPN10, GCK, HHEX
3MP:00053698.7KCNJ11, INS, FOXC2, RBP4, HHEX
4MP:00053798.5HHEX, KCNJ11, INS, NAMPT, CAPN10, GCK
5MP:00053858.1LNPEP, KCNJ11, INS, FOXC2, CAPN10, RBP4
6MP:00053767.7LNPEP, KCNJ11, INS, NAMPT, FOXC2, CAPN10

Publications for Gestational Diabetes

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52PubMed
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Articles related to Gestational Diabetes:

(show top 50)    (show all 931)
idTitleAuthorsYear
1
Relation of the Mediterranean diet with the incidence of gestational diabetes. (24084515)
2014
2
Accelerometry-measured physical activity and inflammation after gestational diabetes. (24070759)
2013
3
Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta. (23954530)
2013
4
Circadian clock gene expression is impaired in gestational diabetes mellitus. (23323702)
2013
5
An association between gestational diabetes mellitus and long-term maternal cardiovascular morbidity. (23749791)
2013
6
A composite risk assessment model to screen for gestational diabetes mellitus among Mediterranean women. (23279935)
2013
7
Ultrasound-guided compared to conventional treatment in gestational diabetes leads to improved birthweight but more insulin treatment: systematic review and meta-analysis. (24372329)
2013
8
Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance. (23560057)
2013
9
Levels of thrombin activatable fibrinolysis inhibitor in gestational diabetes mellitus. (23327722)
2013
10
Quantifying the impact of gestational diabetes mellitus, maternal weight and race on birthweight via quantile regression. (23762279)
2013
11
Microscopic impacts of gestational diabetes mellitus on the umbilical cord. (24292308)
2013
12
NIH consensus development conference: diagnosing gestational diabetes mellitus. (23748438)
2013
13
Circulating apelin levels are associated with cardiometabolic risk factors in women with previous gestational diabetes. (24185940)
2013
14
Simulated estimates of pre-pregnancy and gestational diabetes mellitus in the US: 1980 to 2008. (24039941)
2013
15
IADPSG criteria for diagnosing gestational diabetes mellitus and predicting adverse pregnancy outcomes. (24232664)
2013
16
Gestational diabetes and pregnancy outcome - do we have right diagnostic criteria? (23414434)
2013
17
Are Gestational Diabetes Mellitus and Preconception Diabetes Mellitus Less Common in Non-Hispanic Black Women than in Non-Hispanic White Women? (23793482)
2013
18
The importance of gestational diabetes beyond pregnancy. (24147923)
2013
19
Effect of number of abnormal oral glucose tolerance test (OGTT) values on birthweight in women with gestational diabetes. (23481057)
2013
20
Evolution of diagnostic criteria for gestational diabetes mellitus. (23600679)
2013
21
Awareness of gestational diabetes mellitus among antenatal women in a primary health center in South India. (23776868)
2013
22
Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results. (23805905)
2013
23
Clinical diagnosis of gestational diabetes. (24005127)
2013
24
Comment on: Black et al. The relative contribution of prepregnancy overweight and obesity, gestational weight gain, and IADPSG-defined gestational diabetes mellitus to fetal overgrowth. Diabetes Care 2013;36:56-62. (23881980)
2013
25
Screening tests for gestational diabetes: a systematic review for the U.S. Preventive Services Task Force. (23712349)
2013
26
Gestational diabetes needs to be managed. (23919698)
2013
27
Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes. (23015651)
2012
28
Physician care patterns and adherence to postpartum glucose testing after gestational diabetes mellitus in Oregon. (23071709)
2012
29
Outcome of gestational diabetes mellitus from a tertiary referral center in South India: a case-control study. (24293841)
2012
30
Perinatal maternal and neonatal outcomes in women with gestational diabetes mellitus according to fetal sex. (23089258)
2012
31
Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes. (19857477)
2010
32
Growth factor concentrations and their placental mRNA expression are modulated in gestational diabetes mellitus: possible interactions with macrosomia. (20144210)
2010
33
Association of KCNQ1 polymorphisms with the gestational diabetes mellitus in Korean women. (19850681)
2010
34
The changes of visfatin in serum and its expression in fat and placental tissue in pregnant women with gestational diabetes. (20621376)
2010
35
Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study. (19709150)
2009
36
Diabetes mellitus following gestational diabetes: role of subsequent pregnancy. (18081603)
2008
37
Screening for biomarkers predictive of gestational diabetes mellitus. (18496643)
2008
38
C-reactive protein and metabolic syndrome in women with previous gestational diabetes. (16770838)
2007
39
Mild gestational diabetes as a risk factor for congenital cryptorchidism. (17032715)
2006
40
Evaluation of adiponectin and TNFalpha genes expression in women with gestational diabetes. Preliminary results]. (17373119)
2006
41
Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications. (15778860)
2005
42
Inflammatory markers in women with a recent history of gestational diabetes mellitus. (15816369)
2005
43
Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus. (15095040)
2004
44
Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus. (11772903)
2002
45
Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes. (12235720)
2002
46
Elevated D-glucose induces insulin insensitivity in human umbilical endothelial cells isolated from gestational diabetic pregnancies. (9481683)
1998
47
Gestational diabetes mellitus and subsequent development of overt diabetes mellitus. (9850811)
1998
48
Islet amyloid polypeptide (amylin) does not seem to be directly involved in the development of gestational diabetes mellitus. (9251946)
1997
49
Risk factors for gestational diabetes in black population. (2261842)
1990
50
Insulin receptor binding and glucose metabolism in normal human pregnancy and gestational diabetes mellitus. A review. (2073852)
1990

Variations for Gestational Diabetes

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Gestational Diabetes:

64 (show all 42)
id Symbol AA change Variation ID SNP ID
1GCKp.Glu70LysVAR_003693
2GCKp.Gly80AlaVAR_003694
3GCKp.Gly80SerVAR_003695
4GCKp.Ser131ProVAR_003697
5GCKp.Gly175ArgVAR_003698
6GCKp.Val182MetVAR_003699
7GCKp.Ala188ThrVAR_003700
8GCKp.Val203AlaVAR_003701
9GCKp.Glu221LysVAR_003702
10GCKp.Val226MetVAR_003703
11GCKp.Gly227CysVAR_003704
12GCKp.Thr228MetVAR_003705
13GCKp.Glu256LysVAR_003706
14GCKp.Trp257ArgVAR_003707
15GCKp.Gly261ArgVAR_003708
16GCKp.Glu279GlnVAR_003709rs104894005
17GCKp.Gly299ArgVAR_003710
18GCKp.Glu300GlnVAR_003711
19GCKp.Glu300LysVAR_003712
20GCKp.Leu309ProVAR_003713
21GCKp.Lys414GluVAR_003714
22GCKp.Arg36TrpVAR_010584
23GCKp.Ala53SerVAR_010585
24GCKp.Tyr108HisVAR_010586
25GCKp.His137ArgVAR_010587
26GCKp.Phe150SerVAR_010588
27GCKp.Thr168ProVAR_010589
28GCKp.Thr209MetVAR_010590
29GCKp.Met210ThrVAR_010591
30GCKp.Cys213ArgVAR_010592
31GCKp.Ala259ThrVAR_010593
32GCKp.Gly261GluVAR_010594
33GCKp.Ser336LeuVAR_010595
34GCKp.Val367MetVAR_010596
35GCKp.Cys382TyrVAR_010597
36GCKp.Ala384ThrVAR_010598
37GCKp.Arg392CysVAR_010599
38GCKp.Leu164ProVAR_012350
39GCKp.Met210LysVAR_012351
40GCKp.Ile110ThrVAR_012352
41GCKp.Ala119AspVAR_012353
42GCKp.Gly385ValVAR_012354

Clinvar genetic disease variations for Gestational Diabetes:

1
id Gene Name Type Significance SNP ID Assembly Location
1GCKNM_000162.3(GCK): c.683C> T (p.Thr228Met)single nucleotide variantPathogenicrs80356655GRCh37Chr 7, 44187429: 44187429
2GCKNM_000162.3(GCK): c.214G> A (p.Gly72Arg)single nucleotide variantPathogenicrs193922289GRCh37Chr 7, 44192019: 44192019
3GCKNM_000162.3(GCK): c.645C> G (p.Tyr215Ter)single nucleotide variantPathogenicrs144723656GRCh37Chr 7, 44189393: 44189393
4GCKNM_000162.3(GCK): c.676G> A (p.Val226Met)single nucleotide variantPathogenicrs148311934GRCh37Chr 7, 44189362: 44189362
5GCKNM_000162.3(GCK): c.871A> T (p.Lys291Ter)single nucleotide variantPathogenicrs193922335GRCh37Chr 7, 44186210: 44186210
6GCKNM_000162.3(GCK): c.944T> A (p.Leu315His)single nucleotide variantPathogenicrs193922338GRCh37Chr 7, 44186137: 44186137

Expression for genes affiliated with Gestational Diabetes

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gestational Diabetes

Search GEO for disease gene expression data for Gestational Diabetes.

Pathways for genes affiliated with Gestational Diabetes

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Sources:
50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 60Thomson Reuters, 53QIAGEN, 30KEGG, 55Reactome, 51PharmGKB
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Compounds for genes affiliated with Gestational Diabetes

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Gestational Diabetes according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1chromium picolinate4510.3GCK, INS
2preproinsulin4510.3GCK, INS
3i-app4510.3GCK, INS
4incretin4510.3GCK, INS
5fructosamine45 2411.2INS, RBP4
6repaglinide51 45 1112.2INS, KCNJ11
7gliclazide45 51 1112.1KCNJ11, INS
8glimepiride45 51 1112.1INS, KCNJ11
9niacin45 1111.1INS, NAMPT
10sulfonylurea4510.0KCNJ11, INS, GCK
11katp4510.0GCK, INS, KCNJ11
12diazoxide45 61 29 1113.0KCNJ11, INS, GCK
13tolbutamide45 29 51 1113.0GCK, INS, KCNJ11
14aicar45 24 1112.0INS, GCK
15pioglitazone29 45 51 1113.0RBP4, NAMPT, INS
16c-peptide4510.0KCNJ11, INS, GCK
17rosiglitazone29 45 51 24 1114.0RBP4, NAMPT, INS
18streptozotocin4510.0GCK, INS
19cystine459.9LNPEP, RBP4
20dehydroepiandrosterone sulfate459.8INS, RBP4
21metformin45 51 1111.8KCNJ11, INS, NAMPT, GCK
22fatty acid459.7INS, NAMPT, GCK, RBP4
23sucrose45 24 1111.7RBP4, GCK, LNPEP
24creatinine459.7INS, NAMPT, GCK, RBP4
25nicotinamide45 1110.6NAMPT, INS
26dexamethasone45 51 29 1112.6RBP4, GCK, NAMPT, INS
27leucine459.5RBP4, GCK, KCNJ11, LNPEP
28glycogen45 2410.5LNPEP, INS, CAPN10, GCK
29alanine459.2RBP4, GCK, INS, LNPEP
30arginine459.2LNPEP, KCNJ11, INS, CAPN10, GCK
31cholesterol45 29 24 1111.8RBP4, GCK, CAPN10, NAMPT, INS, ATHS
32glucose458.1RBP4, LNPEP, KCNJ11, INS, NAMPT, FOXC2
33lipid458.1LNPEP, ATHS, INS, NAMPT, FOXC2, CAPN10

GO Terms for genes affiliated with Gestational Diabetes

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16Gene Ontology
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Cellular components related to Gestational Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.6RBP4, GCK, CAPN10, NAMPT, KCNJ11, LNPEP

Biological processes related to Gestational Diabetes according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of gluconeogenesisGO:04572110.2GCK, INS
2positive regulation of glycolytic processGO:04582110.1GCK, INS
3positive regulation of glycogen biosynthetic processGO:04572510.1GCK, INS
4endocrine pancreas developmentGO:03101810.0GCK, INS
5embryonic heart tube developmentGO:0350509.9FOXC2, HHEX
6positive regulation of insulin secretionGO:0320249.8CAPN10, GCK, RBP4
7positive regulation of glucose importGO:0463269.8CAPN10, INS
8glucose homeostasisGO:0425939.7RBP4, GCK, MTNR1B, INS
9insulin receptor signaling pathwayGO:0082869.7FOXC2, NAMPT, INS
10regulation of insulin secretionGO:0507969.7GCK, MTNR1B, INS, KCNJ11
11cell-cell signalingGO:0072679.4LNPEP, INS, NAMPT
12small molecule metabolic processGO:0442818.7GCK, NAMPT, INS, KCNJ11, CYP2R1

Molecular functions related to Gestational Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA binding, bendingGO:0083019.8HHEX, FOXC2

Products for genes affiliated with Gestational Diabetes

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Gestational Diabetes

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet