Aliases & Classifications for Gestational Diabetes

MalaCards integrated aliases for Gestational Diabetes:

Name: Gestational Diabetes 12 14 69
Diabetes Mellitus, Gestational 29 13
Gdm 12 45
Maternal Gestational Diabetes Mellitus 12
Gestational Diabetes Mellitus 12
Diabetes, Gestational 42
Diabetes Gestational 52

Classifications:



External Ids:

Disease Ontology 12 DOID:11714
ICD10 33 O24.4
MeSH 42 D016640
NCIt 47 C34942
UMLS 69 C0085207

Summaries for Gestational Diabetes

MalaCards based summary : Gestational Diabetes, also known as diabetes mellitus, gestational, is related to gestational diabetes insipidus and mody, type ii, and has symptoms including hyperemesis gravidarum, pelvic pain and morning sickness. An important gene associated with Gestational Diabetes is GCK (Glucokinase), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Vascular smooth muscle contraction. The drugs Insulin Aspart and Zinc have been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and placenta, and related phenotypes are homeostasis/metabolism and adipose tissue

Wikipedia : 72 Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels... more...

Related Diseases for Gestational Diabetes

Diseases related to Gestational Diabetes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
id Related Disease Score Top Affiliating Genes
1 gestational diabetes insipidus 12.0
2 mody, type ii 10.9
3 diabetes mellitus, transient neonatal, 3 10.8
4 diabetes mellitus, insulin-dependent 10.8
5 congenital anomalies of kidney and urinary tract 2 10.8
6 intellectual deficit buenos-aires type 10.8 INS INSR
7 writing disorder 10.8 GCK KCNJ11
8 labyrinthine unilateral reactive loss 10.7 GCK INS KCNJ11
9 morning glory syndrome 10.7 GCK INS KCNJ11
10 acute insulin response 10.6 INS KCNJ11 TCF7L2
11 alstrom syndrome 10.6 INS KCNJ11 LEP
12 inclusion body myopathy with paget disease of bone and frontotemporal dementia 10.6 GCK INS KCNJ11
13 hyperinsulinemic hypoglycemia, familial, 4 10.6 ADIPOQ GCK INS
14 chondroma 10.6 INS KCNJ11 LEP
15 acquired hypoprothrombinemia 10.6 ADIPOQ LEP RETN
16 fetal parvovirus syndrome 10.6 INS INSR LEP
17 scleredema adultorum 10.6 ADIPOQ LEP RETN
18 diaphanospondylodysostosis 10.6 GCK INS KCNJ11
19 diabetic encephalopathy 10.5 ADIPOQ INS LEP
20 glomerulosclerosis, focal segmental, 1 10.5 INS INSR IRS1
21 periampullary adenoma 10.5 ADIPOQ INS LEP
22 corpus callosum agenesis of blepharophimosis robin type 10.5 ADIPOQ LEP RETN
23 porokeratosis 10.5 INS LEP SHBG
24 distal muscular dystrophy 10.5 GCK INS KCNJ11
25 skin squamous cell carcinoma 10.5 ADIPOQ INS LEP RBP4
26 hyperlipoproteinemia type iv 10.5 ADIPOQ INS LEP TCF7L2
27 myh-9 related disease 10.4 INS LEP SLC2A4
28 nonsyndromic hereditary sensorineural hearing loss 10.4 ADIPOQ INS LEP RETN
29 diabetic cataract 10.4 GCK INS INSR KCNJ11
30 pelvic muscle wasting 10.4 INS INSR SHBG
31 leigh syndrome with leukodystrophy 10.4 ADIPOQ LEP NAMPT RETN
32 intramuscular hemangioma 10.4 INS LEP RETN
33 obesity 10.4
34 triple x syndrome 10.4 GCK INS INSR KCNJ11
35 skin meningioma 10.3 INS LEP SHBG
36 congenital stationary night blindness 10.3 GCK INS IRS1 KCNJ11
37 chromosome 11p13 deletion syndrome, distal 10.3 ADIPOQ LEP RETN
38 hyperchylomicronemia, late-onset 10.3 ADIPOQ INS INSR
39 hypomagnesemia 3, renal 10.3 ADIPOQ INS LEP SLC2A4
40 pericarditis 10.2 ADIPOQ INS NAMPT RETN
41 fetal macrosomia 10.2
42 mature gastric teratoma 10.2 ADIPOQ INS LEP
43 lipodystrophy, familial partial, type 2 10.2 INS LEP
44 glucose intolerance 10.2
45 paroxysmal nonkinesigenic dyskinesia 2 10.2 INS PTPRN
46 mucinoses 10.2 ADIPOQ INS INSR LEP SHBG
47 endotheliitis 10.1
48 mucolipidoses 10.1 ADIPOQ ADRB3 INS LEP RETN
49 precursor b lymphoblastic lymphoma/leukemia 10.1 INS INSR IRS1 LEP SHBG
50 diabetes insipidus 10.0

Graphical network of the top 20 diseases related to Gestational Diabetes:



Diseases related to Gestational Diabetes

Symptoms & Phenotypes for Gestational Diabetes

UMLS symptoms related to Gestational Diabetes:


hyperemesis gravidarum, pelvic pain, morning sickness

MGI Mouse Phenotypes related to Gestational Diabetes:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ADIPOQ ADIPOR1 ADRB3 GCK INS INSR
2 adipose tissue MP:0005375 10.27 ADIPOQ ADIPOR1 ADRB3 INS INSR IRS1
3 endocrine/exocrine gland MP:0005379 10.25 PTPRN RBP4 SLC2A4 TCF7L2 ADIPOQ ADRB3
4 growth/size/body region MP:0005378 10.24 ADRB3 GCK INS INSR IRS1 IRS2
5 cardiovascular system MP:0005385 10.13 ADIPOQ INS INSR IRS1 IRS2 KCNJ11
6 liver/biliary system MP:0005370 10 ADIPOQ ADIPOR1 GCK INS INSR IRS1
7 muscle MP:0005369 9.9 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
8 renal/urinary system MP:0005367 9.43 ADIPOQ GCK INS INSR IRS2 LEP
9 skeleton MP:0005390 9.23 SLC29A1 TCF7L2 ADIPOQ ADIPOR1 INS IRS1

Drugs & Therapeutics for Gestational Diabetes

Drugs for Gestational Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 229)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin Aspart Approved Phase 4,Phase 3,Phase 2 116094-23-6 16132418
2
Zinc Approved Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
3
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 14219 4091
4
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2 10238-21-8 3488
5
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
8
Insulin Lispro Approved Phase 4,Phase 2 133107-64-9
9
Levonorgestrel Approved, Investigational Phase 4,Phase 2 797-63-7, 17489-40-6 13109
10
Copper Approved Phase 4 7440-50-8 27099
11
Liraglutide Approved Phase 4,Phase 3 204656-20-2 44147092
12
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 58-05-9 143 6006
15
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 67-97-0 6221 10883523 5280795
16
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
17
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 1406-16-2
18
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
19
Resveratrol Experimental, Investigational Phase 4 501-36-0 445154
20
Silicon Investigational Phase 4 7440-21-3 4082203
21 Analgesics Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Anti-Inflammatory Agents Phase 4
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4
25 Antineoplastic Agents, Phytogenic Phase 4
26 Antioxidants Phase 4,Phase 2,Phase 3
27 Antirheumatic Agents Phase 4
28 Hypoglycemic Agents Phase 4,Phase 2,Phase 3,Phase 1
29 insulin Phase 4,Phase 2,Phase 3,Phase 1
30 Insulin, Globin Zinc Phase 4,Phase 2,Phase 3,Phase 1
31 Peripheral Nervous System Agents Phase 4
32 Platelet Aggregation Inhibitors Phase 4
33 Protective Agents Phase 4
34 Pharmaceutical Solutions Phase 4
35 Hematinics Phase 4,Phase 2,Phase 3
36 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
37 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
38 Vitamin B Complex Phase 4,Phase 2,Phase 3
39 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
40 Androgen Antagonists Phase 4
41 Androgens Phase 4
42 Contraceptive Agents Phase 4
43 Contraceptive Agents, Male Phase 4
44
Cyproterone Phase 4 2098-66-0 5284537
45 Cyproterone acetate, ethinyl estradiol drug combination Phase 4
46 Estradiol 17 beta-cypionate Phase 4
47 Estradiol 3-benzoate Phase 4
48 Estradiol valerate Phase 4 979-32-8
49 Hormone Antagonists Phase 4,Phase 3,Phase 2
50 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 462)

id Name Status NCT ID Phase Drugs
1 Can Resveratrol Improve Insulin Sensitivity and Preserve Beta Cell Function Following Gestational Diabetes? Unknown status NCT01997762 Phase 4
2 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
3 Prevention of Diabetes Mellitus Development in Women Who Had Already Experienced A Gestational Diabetes Unknown status NCT00265746 Phase 4 Metformin
4 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
5 Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women Unknown status NCT01511835 Phase 4 Folic Acid
6 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
7 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4 Diane-35 pretreatment;Diane-35 pretreatment
8 Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia Unknown status NCT01718340 Phase 4 Metformin
9 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
10 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
11 Antioxidants in Gestational Diabetes Completed NCT02355197 Phase 4 L-ascorbic acid
12 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4 metformin;insulin
13 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
14 Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women Completed NCT01675310 Phase 4 medical nutrition therapy + metformin
15 Humalog® Mix50/50(tm) as a Treatment for Gestational Diabetes Completed NCT01613807 Phase 4 Insulin LISPRO;Insulin, Long-Acting and Insulin LISPRO
16 Postpartum Glucose Tolerance With Levonorgesterel IUD Use in Women With Recent Gestational Diabetes Completed NCT01022645 Phase 4
17 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
18 Testing Ascensia Contour Glucometer for the Measurement of Blood Glucose Completed NCT00502359 Phase 4
19 Metformin Postpartum for GDM RCT for Reduced Weight Retention Completed NCT01280409 Phase 4 Metformin;Placebo
20 Resistance Exercise Training During Pregnancy: a Randomized Controlled Trial Completed NCT00813657 Phase 4
21 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
22 Preventing Recurrent Gestational Diabetes With Metformin Recruiting NCT02394158 Phase 4 Metformin;placebo
23 Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn Recruiting NCT02508844 Phase 4
24 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4 Myo-inositol
25 The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Pregnancy-induced Diabetes Active, not recruiting NCT01795248 Phase 4 Liraglutide;Placebo
26 Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM Active, not recruiting NCT01856907 Phase 4 Sitagliptin-Metformin;Metformin;Placebo pill
27 Safety and Efficacy of Omnitrope® (rhGH) in Short Children Born Small for Gestational Age (SGA) Active, not recruiting NCT00537914 Phase 4 Somatropin
28 The Impact of Vitamin D Supplementation on Glucose Metabolism in Chinese Women With Former Gestational Diabetes Mellitus Enrolling by invitation NCT03138616 Phase 4 vitamin D
29 Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus Not yet recruiting NCT03029702 Phase 4 Insulin;Glyburide;Metformin
30 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Not yet recruiting NCT03078725 Phase 4 Glyburide;Metformin
31 Probiotics in Newly Recognized Type 1 Diabetes Not yet recruiting NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
32 ZIMBA: Clinical Trial in Paediatric Obesity Not yet recruiting NCT03283813 Phase 4 Placebos;Myoinositol
33 Exenatide Pregnancy Registry - Type 2 Diabetes in Pregnancy Terminated NCT00579150 Phase 4
34 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4 Glyburide;Insulin
35 Pilot Study of Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes Withdrawn NCT00572689 Phase 4 Exenatide
36 Glycemic Profile in Women With Gestational Diabetes Treated With Glyburide Withdrawn NCT01947699 Phase 4 Glyburide
37 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3 Metformin;Insulin
38 Metformin for the Treatment of Diabetes in Pregnancy Unknown status NCT00414245 Phase 3 metformin
39 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3 Probiotics Lactobacillus Rhamnosus
40 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3 Magnesium citrate
41 Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus Completed NCT01087866 Phase 2, Phase 3 Metformin;Insulin
42 Gestational Diabetes: Insulin or Oral Hypoglycemic Agents? Completed NCT01215331 Phase 3 Insulin;Metformin, glyburide and insulin
43 A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS Completed NCT02080377 Phase 3 Glibenclamide;Insulin
44 Safety and Efficacy of Insulin Aspart vs. Regular Human Insulin in Gestational Diabetes Completed NCT00065130 Phase 3 human insulin;insulin NPH;insulin aspart
45 Efficacy of Behavioral Therapy and Exercise in Gestational Diabetes Mellitus (GDM) Completed NCT01506310 Phase 3
46 MAIN STUDY: Low Glycaemic Index (GI) Diet in the Management of GDM SUB-STUDY: The Breast Milk Sub-Study Completed NCT01589757 Phase 2, Phase 3
47 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3 Metformin;Placebo
48 The Effects of Metformin on Pregnancy and Miscarriage Rates in Polycystic Ovary Syndrome (PCOS) Completed NCT00994812 Phase 3 metformin
49 Empowering Patients to Better Manage Diabetes Through Self-Care Completed NCT00254501 Phase 3
50 Lifestyle Interventions for Expectant Mothers (LIFE-Moms Phoenix) - Phoenix Completed NCT01812694 Phase 3

Search NIH Clinical Center for Gestational Diabetes

Cochrane evidence based reviews: diabetes, gestational

Genetic Tests for Gestational Diabetes

Genetic tests related to Gestational Diabetes:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Gestational 29

Anatomical Context for Gestational Diabetes

MalaCards organs/tissues related to Gestational Diabetes:

39
Testes, Ovary, Placenta, Breast, Liver, Endothelial, Thyroid

Publications for Gestational Diabetes

Articles related to Gestational Diabetes:

(show top 50) (show all 1243)
id Title Authors Year
1
GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes. ( 28359772 )
2017
2
The Virtual Office Visit for Women With Gestational Diabetes Mellitus. ( 28077459 )
2017
3
Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes. ( 28363002 )
2017
4
Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development. ( 28072873 )
2017
5
Primary prevention of gestational diabetes mellitus through nutritional factors: a systematic review. ( 28086820 )
2017
6
Adipose Tissue Insulin Resistance in Gestational Diabetes. ( 28080219 )
2017
7
Isolated polyhydramnios in the third trimester: is a gestational diabetes evaluation of value?() ( 28488900 )
2017
8
Use of a clinical-laboratory score to guide treatment of gestational diabetes. ( 28921513 )
2017
9
Metformin in gestational diabetes mellitus. ( 28948948 )
2017
10
Measurement and evaluation of fetal fat layer in the prediction of fetal macrosomia in pregnancies complicated by gestational diabetes. ( 28631075 )
2017
11
Diagnostic protocol for gestational diabetes mellitus (GDM) (IADPSG/ADA, 2011): influence on the occurrence of GDM and mild gestational hyperglycemia (MGH) and on the perinatal outcomes. ( 28053673 )
2017
12
The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus. ( 27334434 )
2017
13
Follow-up after gestational diabetes: a fixable gap in women's preventive healthcare. ( 28948028 )
2017
14
Regulation of the novel adipokines/ hepatokines fetuin A and fetuin B in gestational diabetes mellitus. ( 28183456 )
2017
15
Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723-725. ( 28931712 )
2017
16
Epigenetic adaptation of the placental serotonin transporter gene (SLC6A4) to gestational diabetes mellitus. ( 28650965 )
2017
17
Prevention of neural tube defects and maternal gestational diabetes through the inositol supplementation: preliminary results. ( 28770950 )
2017
18
Outcomes of twin pregnancies complicated by gestational diabetes: a meta-analysis of observational studies. ( 28079866 )
2017
19
The effect of pre-pregnancy body mass index and excessive gestational weight gain on the risk of gestational diabetes in advanced maternal age. ( 28938562 )
2017
20
Response to Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723-725. ( 28931713 )
2017
21
Risk of glucose intolerance and gestational diabetes mellitus in relation to maternal habitual snoring during early pregnancy. ( 28926639 )
2017
22
Polymorphism of the renalase gene in gestational diabetes mellitus. ( 27507673 )
2017
23
CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes. ( 28079868 )
2017
24
"It's a Very Big Burden on Me": Women's Experiences Using Insulin for Gestational Diabetes. ( 28092062 )
2017
25
Is first-trimester HbA1c useful in the diagnosis of gestational diabetes? ( 28918341 )
2017
26
The Placental Microbiota Is Altered among Subjects with Gestational Diabetes Mellitus: A Pilot Study. ( 28932201 )
2017
27
Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial. ( 28938877 )
2017
28
Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis. ( 28930827 )
2017
29
C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes. ( 28919328 )
2017
30
Potential protective effect of lactation against incidence of type 2 diabetes in women with previous gestational diabetes mellitus : A systematic review and meta-analysis. ( 28072911 )
2017
31
Impact of pre-gestational and gestational diabetes mellitus on the expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 in human term placenta. ( 27981520 )
2017
32
DIFFERENTIAL EXPRESSION OF CORD BLOOD NEUROTROPHINS IN GESTATIONAL DIABETES: THE IMPACT OF FETAL GROWTH ABNORMALITIES. ( 28081639 )
2017
33
Investigation of miRNA-binding site variants and risk of gestational diabetes mellitus in Chinese pregnant women. ( 28190110 )
2017
34
Efficacy of metformin in improving glycaemic control & perinatal outcome in gestational diabetes mellitus: A non-randomized study. ( 28948952 )
2017
35
Maternal circulating adipokine profile and insulin resistance in women at high risk of developing gestational diabetes mellitus. ( 28935125 )
2017
36
The GCKR Gene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population. ( 27554451 )
2017
37
Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. ( 28081192 )
2017
38
Macrosomia Rates in Women with Diet-Controlled Gestational Diabetes: A Retrospective Study. ( 28928985 )
2017
39
Phytosterol nutritional supplement improves pregnancy and neonatal complications of gestational diabetes mellitus in a double-blind and placebo-controlled clinical study. ( 28091647 )
2017
40
The Effects of Race and Ethnicity on the Risk of Large-for-Gestational-Age Newborns in Women Without Gestational Diabetes by Prepregnancy Body Mass Index Categories. ( 28092059 )
2017
41
CCL2, CCL5, IL4 and IL15 Gene Polymorphisms in Women with Gestational Diabetes Mellitus. ( 27472286 )
2017
42
Development of Perinatal Mental Illness in Women With Gestational Diabetes Mellitus: A Population-Based Cohort Study. ( 28943221 )
2017
43
Potential prognostic biomarkers of cardiovascular disease in fetal macrosomia: the impact of gestational diabetes. ( 28298172 )
2017
44
Frequency of fetal macrosomia and the associated risk factors in pregnancies without gestational diabetes mellitus. ( 28451039 )
2017
45
Prescribing exercise for prevention and treatment of gestational diabetes: review of suggested recommendations. ( 28084847 )
2017
46
Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study. ( 28077460 )
2017
47
Pregnancies After the Diagnosis of Mild Gestational Diabetes Mellitus and Risk of Cardiometabolic Disorders. ( 28079773 )
2017
48
Gestational diabetes exacerbates maternal immune activation effects in the developing brain. ( 28948973 )
2017
49
Efficacy of probiotic supplement for gestational diabetes mellitus: a systematic review and meta-analysis. ( 28927313 )
2017
50
Implementing a Reminder System in the Northern Part of Belgium to Stimulate Postpartum Screening for Glucose Intolerance in Women with Gestational Diabetes: The "Sweet Pregnancy" Project. ( 28775742 )
2017

Variations for Gestational Diabetes

ClinVar genetic disease variations for Gestational Diabetes:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GCK NM_000162.3(GCK): c.544G> A (p.Val182Met) single nucleotide variant Pathogenic rs587780345 GRCh37 Chromosome 7, 44189603: 44189603
2 GCK NM_000162.3(GCK): c.616A> C (p.Thr206Pro) single nucleotide variant Pathogenic/Likely pathogenic rs587780346 GRCh37 Chromosome 7, 44189422: 44189422
3 GCK NM_000162.3(GCK): c.706G> A (p.Glu236Lys) single nucleotide variant Pathogenic rs587780347 GRCh37 Chromosome 7, 44187406: 44187406

Expression for Gestational Diabetes

Search GEO for disease gene expression data for Gestational Diabetes.

Pathways for Gestational Diabetes

Pathways related to Gestational Diabetes according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.86 GCK HKDC1 INS INSR IRS1 IRS2
2
Show member pathways
12.8 ADRB3 INS INSR IRS1 IRS2
3
Show member pathways
12.72 INS INSR IRS1 IRS2 SLC2A4
4
Show member pathways
12.64 ADIPOQ INS INSR IRS1 IRS2 LEP
5 12.49 ADIPOQ INS INSR IRS1 IRS2 NAMPT
6
Show member pathways
12.47 INS INSR IRS1 IRS2 SLC2A4
7
Show member pathways
12.43 GCK INS IRS1 IRS2 LEP
8
Show member pathways
12.39 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
9
Show member pathways
12.28 ADIPOQ ADIPOR1 INS KCNJ11
10
Show member pathways
12.2 INS INSR IRS1 IRS2 LEP SLC2A4
11
Show member pathways
12.11 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
12
Show member pathways
12.07 INS INSR IRS1 IRS2 SLC2A4
13
Show member pathways
11.95 INS INSR IRS1 IRS2 SLC2A4
14 11.88 ADIPOQ INS IRS1 IRS2 LEP NAMPT
15 11.84 ADIPOQ INS LEP SLC2A4
16 11.8 HKDC1 INS INSR
17 11.64 ADIPOQ ADIPOR1 IRS1 IRS2 LEP SLC2A4
18 11.61 INS INSR IRS1
19 11.56 ADRB3 INS INSR IRS1 IRS2
20 11.52 INS INSR IRS1 LEP
21 11.52 IRS1 IRS2 KCNJ11 LEP SLC2A4
22 11.42 GCK INS KCNJ11
23 11.41 INS INSR IRS1
24 11.33 INS INSR IRS1
25
Show member pathways
11.26 ADIPOQ GCK HKDC1 INS INSR IRS1
26 11.21 INS INSR SLC2A4
27 10.84 INS SLC2A4
28 10.78 ADIPOQ INSR IRS1 IRS2 LEP SLC2A4

GO Terms for Gestational Diabetes

Cellular components related to Gestational Diabetes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin receptor complex GO:0005899 8.62 INSR IRS1

Biological processes related to Gestational Diabetes according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.91 ADRB3 GCK HKDC1 INS INSR SLC2A4
2 response to ethanol GO:0045471 9.86 ADIPOQ LEP RBP4 SLC2A4
3 positive regulation of protein kinase B signaling GO:0051897 9.84 INS INSR LEP TCF7L2
4 female pregnancy GO:0007565 9.83 LEP NAMPT PAPPA
5 positive regulation of MAPK cascade GO:0043410 9.83 ADRB3 INS INSR LEP
6 circadian rhythm GO:0007623 9.82 ADIPOQ LEP NAMPT
7 regulation of insulin secretion GO:0050796 9.81 GCK KCNJ11 LEP
8 response to glucose GO:0009749 9.81 ADIPOQ IRS2 PTPRN TCF7L2
9 response to insulin GO:0032868 9.8 IRS1 LEP PTPRN RETN
10 insulin receptor signaling pathway GO:0008286 9.8 INS INSR IRS1 IRS2 NAMPT
11 cellular response to insulin stimulus GO:0032869 9.8 ADIPOQ GCK INSR IRS1 IRS2 SLC2A4
12 cellular response to glucose stimulus GO:0071333 9.78 IRS2 KCNJ11 SLC29A1
13 positive regulation of insulin secretion GO:0032024 9.76 GCK IRS2 RBP4 TCF7L2
14 brown fat cell differentiation GO:0050873 9.72 ADIPOQ ADRB3 SLC2A4
15 positive regulation of glycolytic process GO:0045821 9.67 INS INSR
16 positive regulation of cellular protein metabolic process GO:0032270 9.67 ADIPOQ INS
17 positive regulation of insulin receptor signaling pathway GO:0046628 9.67 ADIPOR1 INS IRS1 LEP
18 cellular glucose homeostasis GO:0001678 9.66 GCK HKDC1
19 energy reserve metabolic process GO:0006112 9.66 ADRB3 LEP
20 fatty acid oxidation GO:0019395 9.65 ADIPOQ ADIPOR1
21 negative regulation of gluconeogenesis GO:0045721 9.65 ADIPOQ GCK INS
22 positive regulation of glucose import GO:0046326 9.65 ADIPOQ INS INSR IRS1 IRS2
23 cellular response to leptin stimulus GO:0044320 9.64 GCK LEP
24 glucose 6-phosphate metabolic process GO:0051156 9.64 GCK HKDC1
25 positive regulation of fatty acid beta-oxidation GO:0032000 9.63 IRS1 IRS2
26 glucose metabolic process GO:0006006 9.63 ADIPOQ GCK INS IRS2 KCNJ11 LEP
27 leptin-mediated signaling pathway GO:0033210 9.62 ADIPOR1 LEP
28 regulation of fatty acid biosynthetic process GO:0042304 9.62 ADIPOQ ADIPOR1
29 positive regulation of glucose metabolic process GO:0010907 9.61 IRS1 IRS2
30 negative regulation of feeding behavior GO:2000252 9.6 INS RETN
31 adiponectin-activated signaling pathway GO:0033211 9.59 ADIPOQ ADIPOR1
32 positive regulation of respiratory burst GO:0060267 9.58 INS INSR
33 positive regulation of developmental growth GO:0048639 9.58 INSR LEP
34 positive regulation of glycogen biosynthetic process GO:0045725 9.35 GCK INS INSR IRS1 IRS2
35 glucose homeostasis GO:0042593 9.32 ADIPOQ ADIPOR1 GCK INS INSR IRS1
36 positive regulation of cell proliferation GO:0008284 10.04 INS INSR IRS1 IRS2 LEP NAMPT

Molecular functions related to Gestational Diabetes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glucose binding GO:0005536 9.46 GCK HKDC1
2 hormone activity GO:0005179 9.46 ADIPOQ INS LEP RETN
3 mannokinase activity GO:0019158 9.43 GCK HKDC1
4 insulin receptor binding GO:0005158 9.43 INS IRS1 IRS2
5 fructokinase activity GO:0008865 9.4 GCK HKDC1
6 glucokinase activity GO:0004340 9.37 GCK HKDC1
7 hexokinase activity GO:0004396 9.32 GCK HKDC1
8 phosphatidylinositol 3-kinase binding GO:0043548 9.13 INSR IRS1 IRS2
9 insulin-like growth factor receptor binding GO:0005159 8.8 INS INSR IRS1

Sources for Gestational Diabetes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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