MCID: GST010
MIFTS: 41

Gestational Trophoblastic Neoplasm

Categories: Rare diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Gestational Trophoblastic Neoplasm

MalaCards integrated aliases for Gestational Trophoblastic Neoplasm:

Name: Gestational Trophoblastic Neoplasm 12 14
Hydatidiform Mole 12 50 56 42 69
Molar Pregnancy 12 50 56
Gestational Trophoblastic Disease 42 69
Gestational Trophoblastic Neoplasia 12
Gestational Trophoblastic Neoplasms 69
Hydatidiform Mole, Recurrent, 1 69
Hydatid Mole 50
Hydm 50

Characteristics:

Orphanet epidemiological data:

56
hydatidiform mole
Inheritance: Autosomal recessive,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:3590
ICD10 33 O01 O01.0 O01.9
ICD9CM 35 630
Orphanet 56 ORPHA99927
MESH via Orphanet 43 D006828
UMLS via Orphanet 70 C0020217
ICD10 via Orphanet 34 O01.0 O01.1 O01.9

Summaries for Gestational Trophoblastic Neoplasm

NIH Rare Diseases : 50 molar pregnancy is a condition in which the placenta does not develop properly. the symptoms of molar pregnancy, which may include vaginal bleeding, severe morning sickness, stomach cramps, and high blood pressure, typically begin around the 10th week of pregnancy. because the embryo does not form or is malformed in molar pregnancies, and because there is a small risk of developing a cancer called choriocarcinoma, a d&c is usually performed. last updated: 7/15/2013

MalaCards based summary : Gestational Trophoblastic Neoplasm, also known as hydatidiform mole, is related to placental site trophoblastic tumor and recurrent hydatidiform mole, and has symptoms including spontaneous abortion, menometrorrhagia and hyperthyroidism. An important gene associated with Gestational Trophoblastic Neoplasm is NLRP7 (NLR Family Pyrin Domain Containing 7), and among its related pathways/superpathways is Nucleotide-binding Oligomerization Domain (NOD) pathway. The drugs Nitroglycerin and Chorionic Gonadotropin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and placenta.

Related Diseases for Gestational Trophoblastic Neoplasm

Diseases related to Gestational Trophoblastic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
id Related Disease Score Top Affiliating Genes
1 placental site trophoblastic tumor 24.8 CD2AP CDKN1C CSH1 CSH2 KHDC3L LGALS1
2 recurrent hydatidiform mole 12.6
3 hydatidiform mole, recurrent, 1 12.6
4 partial hydatidiform mole 12.6
5 hydatidiform mole, recurrent, 2 12.5
6 gestational trophoblastic tumor 11.1
7 multiple benign circumferential skin creases on limbs 10.7 KHDC3L NLRP7
8 trisomy 2 mosaicism 10.7 KHDC3L NLRP7
9 trophoblastic neoplasm 10.5
10 glutaric aciduria iii 10.3 CDKN1C NR0B1
11 nephronophthisis 19 10.3 KHDC3L NLRP2 NLRP7
12 testicular pure germ cell tumor 10.3 CSH1 CSH2
13 gingival hypertrophy 10.2 CSH1 CSH2
14 uveal melanoma 10.2 CSH1 CSH2
15 testicular malignant germ cell cancer 10.2 CSH1 CSH2
16 testicular germ cell cancer 10.1 CSH1 CSH2
17 epidermolytic acanthoma 10.1 CSH1 CSH2
18 necrotic uveal melanoma 10.0 CSH1 OXT
19 hyperbiliverdinemia 10.0 CD2AP CDKN1C NR0B1
20 centrotemporal epilepsy 10.0 CDKN1C NR0B1
21 peripheral nervous system disease 9.9 CSH1 CSH2
22 mucinous cystadenocarcinoma 9.9 CDKN1C CSH1 CSH2
23 nephrolithiasis/osteoporosis, hypophosphatemic, 1 9.9 CDKN1C NLRP2 PHLDA2
24 microcephaly, seizures, and developmental delay 9.9 CDKN1C KHDC3L NLRP7 PHLDA2
25 lacrimal gland mucoepidermoid carcinoma 9.8 CSH1 CSH2
26 nervous system disease 9.8
27 pleurisy 9.8
28 hypothyroidism 9.8
29 epithelioid trophoblastic tumor 9.8
30 placenta accreta 9.8
31 articulation disorder 9.7 CSH1 CSH2 OXT
32 breast disease 9.7 CSH1 CSH2 OXT
33 spondylolysis 9.7 CSH1 CSH2 OXT
34 agnosia 9.2 CDKN1C CSH1 KHDC3L NLRP2 NLRP7 NR0B1
35 thoracic outlet syndrome 8.4 CDKN1C CSH1 CSH2 KHDC3L LGALS1 NLRP7

Graphical network of the top 20 diseases related to Gestational Trophoblastic Neoplasm:



Diseases related to Gestational Trophoblastic Neoplasm

Symptoms & Phenotypes for Gestational Trophoblastic Neoplasm

Human phenotypes related to Gestational Trophoblastic Neoplasm:

56 32 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 spontaneous abortion 56 32 hallmark (90%) Very frequent (99-80%) HP:0005268
2 menometrorrhagia 56 32 hallmark (90%) Very frequent (99-80%) HP:0400008
3 hyperthyroidism 56 Occasional (29-5%)
4 anemia 56 Very frequent (99-80%)
5 nausea and vomiting 56 Very frequent (99-80%)
6 preeclampsia 56 Very frequent (99-80%)
7 enlarged uterus 56 Very frequent (99-80%)
8 high maternal serum chorionic gonadotropin 32 hallmark (90%) HP:0011433

Drugs & Therapeutics for Gestational Trophoblastic Neoplasm

Drugs for Gestational Trophoblastic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 168)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroglycerin Approved, Investigational Phase 4,Phase 2 55-63-0 4510
2 Chorionic Gonadotropin Phase 4
3
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
4
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
5
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
6
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
7
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
8
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
9
Palivizumab Approved, Investigational Phase 3 188039-54-5
10
Ribavirin Approved Phase 3 36791-04-5 37542
11
Fluconazole Approved Phase 3 86386-73-4 3365
12
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
13
Captopril Approved Phase 3 62571-86-2 44093
14
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
15
Carboplatin Approved Phase 3,Phase 1 41575-94-4 10339178 498142 38904
16
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
17
Levoleucovorin Approved Phase 2, Phase 3 68538-85-2
18
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
19
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
20
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
21
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
22
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
23
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
24
Norgestimate Approved Phase 3 35189-28-7 6540478
25
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
26
Mycophenolic acid Approved Phase 3 24280-93-1 446541
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
28
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
29 Liver Extracts Phase 3,Phase 2,Phase 1
30 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
31 Antibiotics, Antitubercular Phase 3,Phase 2
32 Anti-Infective Agents Phase 3,Phase 2,Phase 1
33 Antimetabolites Phase 3,Phase 2
34 Antimetabolites, Antineoplastic Phase 3,Phase 2
35 Antirheumatic Agents Phase 3,Phase 2
36 Dermatologic Agents Phase 3,Phase 2
37 Folic Acid Antagonists Phase 3,Phase 2
38 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
39 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
40 Vitamin B Complex Phase 3,Phase 2
41 Hematinics Phase 3,Phase 2
42 Micronutrients Phase 3,Phase 2
43 Trace Elements Phase 3,Phase 2
44 Vitamins Phase 3,Phase 2
45 Protective Agents Phase 3,Phase 2
46 Radiation-Protective Agents Phase 3
47 Antifungal Agents Phase 3,Phase 2
48 Antiparasitic Agents Phase 3
49 Antiprotozoal Agents Phase 3
50 Liposomal amphotericin B Phase 3

Interventional clinical trials:

(show top 50) (show all 72)

id Name Status NCT ID Phase Drugs
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole Recruiting NCT01630954 Phase 4
3 Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3 Methotrexate
4 RCT on the Efficacy of Methotrexate for the Prevention of GTD Completed NCT01984099 Phase 3 Methotrexate;Vitamin B Complex
5 Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer Completed NCT00058071 Phase 3 amifostine trihydrate
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
9 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
10 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
11 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
12 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
13 Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms Recruiting NCT02606539 Phase 2, Phase 3 Methotrexate plus folinic acid alone
14 Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01823315 Phase 3 MTX 1;MTX 2
15 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01535053 Phase 3 Leucovorin Calcium;Methotrexate
16 Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Not yet recruiting NCT02639650 Phase 3 Etoposide;actinomycin D;methotrexate;vincristine;cyclophosphamide;Paclitaxel;Cisplatin;Carboplatin
17 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
18 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
19 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
20 Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia Completed NCT00003688 Phase 2
21 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2 Pemetrexed
22 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
23 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
24 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
25 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
26 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
27 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
28 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
29 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2 ravuconazole
30 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
31 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
32 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2 methotrexate;methylprednisolone;prednisone
33 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
34 Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias Recruiting NCT03135769 Phase 2 Avelumab administration at 10mg/kg
35 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2 TRC105;Bevacizumab
36 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Recruiting NCT01764802 Phase 2
37 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
38 Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy Terminated NCT00096187 Phase 2 pemetrexed disodium
39 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
40 Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections Unknown status NCT00769613 Phase 1
41 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
42 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1 cefepime hydrochloride
43 Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1 carboplatin;etoposide;ifosfamide
44 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1 aminocamptothecin colloidal dispersion
45 Donor Mesenchymal Stem Cell Infusion in Treating Patients With Acute or Chronic Graft-Versus-Host Disease After Undergoing a Donor Stem Cell Transplant Completed NCT00361049 Phase 1
46 Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant Completed NCT00569283 Phase 1
47 Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy Completed NCT00509691 Phase 1
48 Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00957736 Phase 1
49 Detection of Human Chorionic Gonadotropin by Interferometry in Gestational Trophoblastic Disease Unknown status NCT00166790 chemotherapy agents
50 Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant Completed NCT00293384 Aprepitant;Cyclophosphamide;Dexamethasone;Granisetron hydrochloride

Search NIH Clinical Center for Gestational Trophoblastic Neoplasm

Cochrane evidence based reviews: hydatidiform mole

Genetic Tests for Gestational Trophoblastic Neoplasm

Anatomical Context for Gestational Trophoblastic Neoplasm

MalaCards organs/tissues related to Gestational Trophoblastic Neoplasm:

39
Bone, Bone Marrow, Placenta, Breast, Uterus, Colon, T Cells

Publications for Gestational Trophoblastic Neoplasm

Articles related to Gestational Trophoblastic Neoplasm:

(show all 19)
id Title Authors Year
1
Unusual Presentation of Hypothyroidism in a Pregnant Woman, Mimicking Gestational Trophoblastic Neoplasm. ( 27034864 )
2016
2
Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm. ( 26599757 )
2015
3
Klippel-Trenaunay syndrome and gestational trophoblastic neoplasm. ( 25228614 )
2014
4
A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. ( 25396428 )
2014
5
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. ( 24106538 )
2013
6
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. ( 22055909 )
2012
7
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. ( 18714577 )
2008
8
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. ( 17940785 )
2008
9
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. ( 16681792 )
2006
10
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. ( 16263566 )
2005
11
MR appearance of placental site gestational trophoblastic neoplasm. ( 8846312 )
1996
12
[Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. ( 1337871 )
1992
13
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. ( 1661266 )
1991
14
Gestational trophoblastic neoplasm of the uterus: MR assessment. ( 3020607 )
1986
15
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. ( 6094315 )
1984
16
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. ( 6093460 )
1984
17
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. ( 46716 )
1975
18
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. ( 4377042 )
1973
19
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. ( 4332357 )
1972

Variations for Gestational Trophoblastic Neoplasm

ClinVar genetic disease variations for Gestational Trophoblastic Neoplasm:

6 (show all 13)
id Gene Variation Type Significance SNP ID Assembly Location
1 NLRP7 NM_001127255.1(NLRP7): c.352+1G> A single nucleotide variant Pathogenic rs104895504 GRCh37 Chromosome 19, 55452298: 55452298
2 NLRP7 NM_001127255.1(NLRP7): c.2471+1G> A single nucleotide variant Pathogenic rs104895505 GRCh37 Chromosome 19, 55445856: 55445856
3 NLRP7 NM_001127255.1(NLRP7): c.2077C> T (p.Arg693Trp) single nucleotide variant Pathogenic rs104895506 GRCh37 Chromosome 19, 55449464: 55449464
4 NLRP7 NM_001127255.1(NLRP7): c.2078G> C (p.Arg693Pro) single nucleotide variant Pathogenic rs104895502 GRCh37 Chromosome 19, 55449463: 55449463
5 NLRP7 NM_001127255.1(NLRP7): c.2738A> G (p.Asn913Ser) single nucleotide variant Pathogenic rs104895503 GRCh37 Chromosome 19, 55441939: 55441939
6 NLRP7 NM_001127255.1(NLRP7): c.1294C> T (p.Arg432Ter) single nucleotide variant Pathogenic rs104895530 GRCh37 Chromosome 19, 55450893: 55450893
7 NLRP7 NLRP7, 1-BP INS, 337G insertion Pathogenic
8 NLRP7 NM_001127255.1(NLRP7): c.2078G> A (p.Arg693Gln) single nucleotide variant Pathogenic rs104895502 GRCh37 Chromosome 19, 55449463: 55449463
9 NLRP7 NM_001127255.1(NLRP7): c.1193T> G (p.Leu398Arg) single nucleotide variant Pathogenic rs104895548 GRCh37 Chromosome 19, 55450994: 55450994
10 NLRP7 NM_001127255.1(NLRP7): c.1951C> T (p.Pro651Ser) single nucleotide variant Pathogenic rs104895549 GRCh37 Chromosome 19, 55449590: 55449590
11 NLRP7 NLRP7, 14-BP DUP, NT939 duplication Pathogenic
12 NLRP7 NM_001127255.1(NLRP7): c.2030delT (p.Leu677Profs) deletion Pathogenic rs104895554 GRCh37 Chromosome 19, 55449511: 55449511
13 NLRP7 NM_001127255.1(NLRP7): c.337_338insG (p.Glu113Glyfs) insertion Pathogenic rs104895553 GRCh37 Chromosome 19, 55452314: 55452314

Expression for Gestational Trophoblastic Neoplasm

Search GEO for disease gene expression data for Gestational Trophoblastic Neoplasm.

Pathways for Gestational Trophoblastic Neoplasm

Pathways related to Gestational Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.24 NLRP2 NLRP7

GO Terms for Gestational Trophoblastic Neoplasm

Biological processes related to Gestational Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 placenta development GO:0001890 8.96 CDKN1C PHLDA2
2 adrenal gland development GO:0030325 8.62 CDKN1C NR0B1

Molecular functions related to Gestational Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CSH1 CSH2 OXT

Sources for Gestational Trophoblastic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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