GTN
MCID: GST010
MIFTS: 61

Gestational Trophoblastic Neoplasm (GTN) malady

Reproductive diseases, Cancer diseases categories

Summaries for Gestational Trophoblastic Neoplasm

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Sources:
42NIH Rare Diseases, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Molar pregnancy is a condition in which the placenta does not develop properly. the symptoms of molar pregnancy, which may include vaginal bleeding, severe morning sickness, stomach cramps, and high blood pressure, typically begin around the 10th week of pregnancy. because the embryo does not form or is malformed in molar pregnancies, and because there is a small risk of developing a cancer called choriocarcinoma, a d&c is usually performed. last updated: 7/15/2013

MalaCards: Gestational Trophoblastic Neoplasm, also known as hydatidiform mole, is related to trophoblastic neoplasm and gestational trophoblastic tumor, and has symptoms including spontaneous abortions, vaginal/vulvar neoplasm/tumor/carcinoma/cancer and antenatal period/pregnancy anomalies. An important gene associated with Gestational Trophoblastic Neoplasm is NLRP7 (NLR family, pyrin domain containing 7), and among its related pathways is Development Prolactin receptor signaling. The compounds cloprostenol and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and kidney.

Description from OMIM:46 231090,614293

Aliases & Classifications for Gestational Trophoblastic Neoplasm

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 42NIH Rare Diseases, 9diseasecard, 22GTR, 46OMIM, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
complete hydatidiform mole:
Inheritance: Autosomal recessive,Sporadic; Age of onset: Adulthood; Age of death: Normal
gestational trophoblastic neoplasm:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

gestational trophoblastic neoplasm 8 10 48
hydatidiform mole 8 9 42 22 46 44 60
complete hydatidiform mole 48 60
molar pregnancy 8 42
gestational trophoblastic neoplasia 8
gestational trophoblastic neoplasms 60
complete molar pregnancy 48
hydatid mole 42
hydm 42
gtn 48


External Ids:

Disease Ontology8 DOID:3590
NCIt39 C3110
ICD9CM27 630
MeSH34 D006828
SNOMED-CT via Orphanet57 237249000, 416441004, 417475006
ICD10 via Orphanet26 O01.0
MESH via Orphanet35 D031901
UMLS via Orphanet61 C1135868
ICD1025 O01

Related Diseases for Gestational Trophoblastic Neoplasm

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gestational Trophoblastic Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1trophoblastic neoplasm31.1CGA, CGB5, INHA
2gestational trophoblastic tumor30.5CGB5
3ovarian cyst30.4CGB5, CGA
4placental site trophoblastic tumor30.3INHA, CGB5, CGA
5pre-eclampsia30.2INHA, AFP, CGB5, CGA, PSG1
6epithelioid trophoblastic tumor30.2CSH2, CSH1, INHA
7thyroiditis30.2CGA
8choriocarcinoma30.2TFPI2, PSG1, PSG9, CSH1, CSH2, STARD7
9partial hydatidiform mole10.4
10herpes gestationis10.4
11invasive mole10.3
12ovarian hyperstimulation syndrome10.3
13central nervous system disease10.2
14nervous system disease10.2
15prostatitis10.2
16placenta accreta10.2
17pleurisy10.2
18hydatidiform mole, recurrent10.2
19eclampsia10.2
20peripartum cardiomyopathy10.2
21hydatidiform mole, recurrent, 210.2
22membranoproliferative glomerulonephritis10.2
23cervix endometriosis10.2
24papillary carcinoma10.2
25fallopian tube endometriosis10.2
26ovarian endometriosis10.2
27endometriosis of ovary10.2
28parovarian cyst10.2
29hydronephrosis10.2
30acromegaly10.2
31pregnancy adenoma10.2
32cortical blindness10.2
33ovary papillary carcinoma10.2
34infertility10.2
35ulceration of vulva10.2
36papillary adenoma10.2
37adenoma10.2
38arthropathy10.2
39breast cancer10.2
40cervicitis10.2
41chromosomal disease10.2
42endometriosis10.2
43endometriosis of uterus10.2
44glomerulonephritis10.2
45gonadal dysgenesis10.2
46hermaphroditism10.2
47hypertension10.2
48liver sarcoma10.2
49ovary sarcoma10.2
50placenta praevia10.2

Graphical network of the top 20 diseases related to Gestational Trophoblastic Neoplasm:



Diseases related to gestational trophoblastic neoplasm

Clinical Features for Gestational Trophoblastic Neoplasm

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

231090,614293

Clinical synopsis from OMIM:

231090

Symptoms:

48 (show all 9)
  • spontaneous abortions
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • neoplasms/tumors
  • kidney/renal neoplasm/tumor/carcinoma/cancer
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Gestational Trophoblastic Neoplasm

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gestational Trophoblastic Neoplasm

Drug clinical trials:

Search ClinicalTrials for Gestational Trophoblastic Neoplasm

Search NIH Clinical Center for Gestational Trophoblastic Neoplasm

Search CenterWatch for Gestational Trophoblastic Neoplasm

Genetic Tests for Gestational Trophoblastic Neoplasm

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Sources:
22GTR
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Genetic tests related to Gestational Trophoblastic Neoplasm:

id Genetic test Affiliating Genes
1 Hydatidiform Mole22

Anatomical Context for Gestational Trophoblastic Neoplasm

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Sources:
32MalaCards
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MalaCards organs/tissues related to Gestational Trophoblastic Neoplasm:

32
Placenta, Lung, Kidney, Liver, Colon, Uterus

Animal Models for Gestational Trophoblastic Neoplasm or affiliated genes

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Publications for Gestational Trophoblastic Neoplasm

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50PubMed
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Articles related to Gestational Trophoblastic Neoplasm:

(show all 15)
idTitleAuthorsYear
1
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. (24106538)
2013
2
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. (22055909)
2012
3
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. (18714577)
2008
4
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. (17940785)
2008
5
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. (16681792)
2006
6
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. (16263566)
2005
7
MR appearance of placental site gestational trophoblastic neoplasm. (8846312)
1996
8
Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. (1337871)
1992
9
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. (1661266)
1991
10
Gestational trophoblastic neoplasm of the uterus: MR assessment. (3020607)
1986
11
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. (6094315)
1984
12
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. (6093460)
1984
13
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. (46716)
1975
14
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. (4377042)
1973
15
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. (4332357)
1972

Genetic Variations for Gestational Trophoblastic Neoplasm

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Gestational Trophoblastic Neoplasm:

62
id Symbol AA change Variation ID SNP ID
1NLRP7p.Arg693ProVAR_026711
2NLRP7p.Arg693TrpVAR_026712
3NLRP7p.Asn913SerVAR_026713rs104895503
4NLRP7p.Leu398ArgVAR_059035
5NLRP7p.Pro651SerVAR_059036
6NLRP7p.Arg693GlnVAR_059037
7NLRP7p.Pro716AlaVAR_059038
8NLRP7p.Arg721TrpVAR_059039
9NLRP7p.Cys761TyrVAR_059040

Expression for genes affiliated with Gestational Trophoblastic Neoplasm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gestational Trophoblastic Neoplasm

Search GEO for disease gene expression data for Gestational Trophoblastic Neoplasm.

Pathways for genes affiliated with Gestational Trophoblastic Neoplasm

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29KEGG, 12EMD Millipore
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Pathways related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Prolactin receptor signaling
Hide members
9.5CGA, CSH1, CSH2

Compounds for genes affiliated with Gestational Trophoblastic Neoplasm

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cloprostenol28 4411.2INHA, CGA
211-ketotestosterone4410.2CGA, CGB5
3organon4410.2CGB5, CGA
4trilostane44 1111.1CGB5, CGA
5estradiol benzoate4410.1CGA, CGB5
6leuprolide44 59 28 1113.1CGB5, CGA
717-hydroxypregnenolone4410.1CGB5, CGA
8dihydroprogesterone4410.0CGA, CGB5
98-bromo-cyclic amp4410.0CGB5, CGA
10cetrorelix44 28 1112.0CGB5, CGA
1122r-hydroxycholesterol44 2810.9CGB5, CGA
12clomiphene citrate449.9AFP, CGB5, CGA
133beta-hydroxysteroid449.9CGA, CGB5, INHA
14ifosfamide44 1110.9AFP, CGB5, CGA
15diethylstilbestrol44 28 1111.9AFP, CGB5, CGA
16buserelin44 28 1111.9CGA, CGB5
17vinblastine44 49 1111.9CGA, CGB5, AFP
18androstenedione44 2410.8CGA, CGB5, INHA
19bleomycin44 1110.8CGA, CGB5, AFP
20leuprolide acetate449.8CGA, CGB5
21mifepristone44 59 28 1112.8CGA, CGB5, AFP
22ctp449.7CGB5, CGA
23gnrh449.7CGA, CGB5, NR0B1, INHA
24testosterone44 59 11 2412.6NR0B1, AFP, CGB5, CGA
25acth449.6CGB5, NR0B1, CDKN1C, INHA, PAM
26lutein449.5CGA, CGB5
27paraffin449.3INHA, AFP, CGB5, CGA
28steroid449.2CGA, CGB5, AFP, NR0B1, INHA
29oestriol449.1AFP, CGB5, CGA, PSG1
30estradiol44 11 2410.8PSG1, CGA, CGB5, AFP, INHA
31zinc44 249.6PSG1, CTSC, CGB5, AFP, NR0B1, PAM
32progesterone44 59 28 11 2412.6PSG1, CGA, CGB5, AFP, NR0B1, INHA

GO Terms for genes affiliated with Gestational Trophoblastic Neoplasm

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16Gene Ontology
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Cellular components related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5PAM, INHA, CGA, PSG1, PSG9, PSG6

Biological processes related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:04232610.0INHA, CDKN1C
2female pregnancyGO:0075658.0PSG1, PSG9, PSG6, CSH1

Molecular functions related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7INHA, CGA, CSH1

Products for genes affiliated with Gestational Trophoblastic Neoplasm

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gestational Trophoblastic Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet