GTN
MCID: GST010
MIFTS: 50

Gestational Trophoblastic Neoplasm (GTN) malady

Reproductive, Cancer categories

Summaries for Gestational Trophoblastic Neoplasm

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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NIH Rare Diseases:43 Molar pregnancy is a condition in which the placenta does not develop properly. the symptoms of molar pregnancy, which may include vaginal bleeding, severe morning sickness, stomach cramps, and high blood pressure, typically begin around the 10th week of pregnancy. because the embryo does not form or is malformed in molar pregnancies, and because there is a small risk of developing a cancer called choriocarcinoma, a d&c is usually performed. last updated: 7/15/2013

MalaCards: Gestational Trophoblastic Neoplasm, also known as hydatidiform mole, is related to trophoblastic neoplasm and gestational trophoblastic tumor, and has symptoms including lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer, kidney/renal neoplasm/tumor/carcinoma/cancer and neoplasms/tumors. An important gene associated with Gestational Trophoblastic Neoplasm is NLRP7 (NLR family, pyrin domain containing 7), and among its related pathways is Development Prolactin receptor signaling. The compounds cloprostenol and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include uterus, colon and placenta.

Wikipedia:64 Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours. These... more...

Description from OMIM:47 231090,614293

Aliases & Classifications for Gestational Trophoblastic Neoplasm

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 43NIH Rare Diseases, 9diseasecard, 22GTR, 47OMIM, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 26ICD10 via Orphanet, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Reproductive


Characteristics (Orphanet epidemiological data):

49
complete hydatidiform mole:
Inheritance: Autosomal recessive,Sporadic; Age of onset: Adulthood; Age of death: Normal
gestational trophoblastic neoplasm:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

gestational trophoblastic neoplasm 8 10 49
hydatidiform mole 8 9 43 22 47 45 61
complete hydatidiform mole 49 61
molar pregnancy 8 43
gestational trophoblastic neoplasia 8
gestational trophoblastic neoplasms 61
complete molar pregnancy 49
hydatid mole 43
hydm 43
gtn 49


External Ids:

Disease Ontology8 DOID:3590
NCIt40 C3110
ICD9CM27 630
MeSH35 D006828
ICD10 via Orphanet26 O01.0
MESH via Orphanet36 D031901
SNOMED-CT via Orphanet58 416441004, 417475006
UMLS via Orphanet62 C1135868
ICD1025 O01

Related Diseases for Gestational Trophoblastic Neoplasm

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gestational Trophoblastic Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1trophoblastic neoplasm31.2CGA, CGB5, INHA
2gestational trophoblastic tumor30.6CGB5
3ectopic pregnancy30.5PSG1, CGA, CGB5
4dysgerminoma30.5CGA, CGB5, AFP, INHA
5placental site trophoblastic tumor30.3INHA, CGB5, CGA
6epithelioid trophoblastic tumor30.2CSH2, CSH1, INHA
7anencephaly30.2CGA, AFP
8down syndrome30.2PSG1, CGA, CGB5, AFP, INHA
9invasive mole10.8
10triploidy10.6
11partial hydatidiform mole10.5
12herpes gestationis10.4
13pemphigoid gestationis10.3
14ovarian hyperstimulation syndrome10.3
15n syndrome10.3
16heart tumor10.3
17malignant germ cell tumor10.3
18germ cell tumors10.3
19male germ cell tumor10.3
20placenta accreta10.2
21hydatidiform mole, recurrent10.2
22eclampsia10.2
23peripartum cardiomyopathy10.2
24hydatidiform mole, recurrent, 210.2
25pregnancy loss10.2
26membranoproliferative glomerulonephritis10.2
27cervix endometriosis10.2
28papillary carcinoma10.2
29fallopian tube endometriosis10.2
30ovarian endometriosis10.2
31parovarian cyst10.2
32hydronephrosis10.2
33acromegaly10.2
34pregnancy adenoma10.2
35cortical blindness10.2
36ovary papillary carcinoma10.2
37infertility10.2
38papillary adenoma10.2
39adenoma10.2
40arthropathy10.2
41tuberculosis10.2
42pregnancy loss, recurrent 110.2
43hydrocephalus, nonsyndromic, autosomal recessive 210.2
44insulin resistance10.2
45blindness10.2
46acute intermittent porphyria10.2
47acute porphyria10.2
48thrombotic thrombocytopenic purpura10.0
49graves' disease10.0
50thyrotoxicosis10.0

Graphical network of the top 20 diseases related to Gestational Trophoblastic Neoplasm:



Diseases related to gestational trophoblastic neoplasm

Clinical Features for Gestational Trophoblastic Neoplasm

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

231090,614293

Clinical synopsis from OMIM:

231090

Symptoms:

49 (show all 9)
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • kidney/renal neoplasm/tumor/carcinoma/cancer
  • neoplasms/tumors
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • hepatic/liver neoplasm/tumor/carcinoma/cancer
  • antenatal period/pregnancy anomalies
  • vaginal/vulvar neoplasm/tumor/carcinoma/cancer
  • spontaneous abortions

Drugs & Therapeutics for Gestational Trophoblastic Neoplasm

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gestational Trophoblastic Neoplasm

Drug clinical trials:

Search ClinicalTrials for Gestational Trophoblastic Neoplasm

Search NIH Clinical Center for Gestational Trophoblastic Neoplasm

Search CenterWatch for Gestational Trophoblastic Neoplasm

Genetic Tests for Gestational Trophoblastic Neoplasm

Sources:
22GTR
See all sources

Genetic tests related to Gestational Trophoblastic Neoplasm:

id Genetic test Affiliating Genes
1 Hydatidiform Mole22

Anatomical Context for Gestational Trophoblastic Neoplasm

Sources:
33MalaCards
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MalaCards organs/tissues related to Gestational Trophoblastic Neoplasm:

33
Uterus, Colon, Placenta

Animal Models for Gestational Trophoblastic Neoplasm or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Gestational Trophoblastic Neoplasm

Sources:
51PubMed
See all sources

Articles related to Gestational Trophoblastic Neoplasm:

(show all 15)
idTitleAuthorsYear
1
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. (24106538)
2013
2
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. (22055909)
2012
3
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. (18714577)
2008
4
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. (17940785)
2008
5
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. (16681792)
2006
6
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. (16263566)
2005
7
MR appearance of placental site gestational trophoblastic neoplasm. (8846312)
1996
8
Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. (1337871)
1992
9
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. (1661266)
1991
10
Gestational trophoblastic neoplasm of the uterus: MR assessment. (3020607)
1986
11
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. (6094315)
1984
12
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. (6093460)
1984
13
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. (46716)
1975
14
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. (4377042)
1973
15
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. (4332357)
1972

Genetic Variations for Gestational Trophoblastic Neoplasm

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Gestational Trophoblastic Neoplasm:

63
id Symbol AA change Variation SNP ID
1NLRP7p.Arg693ProVAR_026711
2NLRP7p.Arg693TrpVAR_026712
3NLRP7p.Asn913SerVAR_026713rs104895503
4NLRP7p.Leu398ArgVAR_059035
5NLRP7p.Pro651SerVAR_059036
6NLRP7p.Arg693GlnVAR_059037
7NLRP7p.Pro716AlaVAR_059038
8NLRP7p.Arg721TrpVAR_059039
9NLRP7p.Cys761TyrVAR_059040

Expression for genes affiliated with Gestational Trophoblastic Neoplasm

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gestational Trophoblastic Neoplasm

Search GEO for disease gene expression data for Gestational Trophoblastic Neoplasm.

Pathways for genes affiliated with Gestational Trophoblastic Neoplasm

Sources:
30KEGG, 12EMD Millipore
See all sources

Pathways related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Prolactin receptor signaling
Hide members
9.5CGA, CSH1, CSH2

Compounds for genes affiliated with Gestational Trophoblastic Neoplasm

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cloprostenol29 4511.2INHA, CGA
211-ketotestosterone4510.2CGA, CGB5
3organon4510.2CGB5, CGA
4trilostane45 1111.1CGB5, CGA
5estradiol benzoate4510.1CGA, CGB5
6leuprolide45 60 29 1113.1CGB5, CGA
717-hydroxypregnenolone4510.1CGB5, CGA
8dihydroprogesterone4510.0CGA, CGB5
98-bromo-cyclic amp4510.0CGB5, CGA
10cetrorelix45 29 1112.0CGB5, CGA
1122r-hydroxycholesterol45 2910.9CGB5, CGA
12clomiphene citrate459.9AFP, CGB5, CGA
133beta-hydroxysteroid459.9CGA, CGB5, INHA
14ifosfamide45 1110.9AFP, CGB5, CGA
15diethylstilbestrol45 29 1111.9AFP, CGB5, CGA
16buserelin45 29 1111.9CGA, CGB5
17vinblastine45 50 1111.9CGA, CGB5, AFP
18androstenedione45 2410.8CGA, CGB5, INHA
19bleomycin45 1110.8CGA, CGB5, AFP
20leuprolide acetate459.8CGA, CGB5
21mifepristone45 60 29 1112.8CGA, CGB5, AFP
22ctp459.7CGB5, CGA
23gnrh459.7CGA, CGB5, NR0B1, INHA
24testosterone45 60 11 2412.6NR0B1, AFP, CGB5, CGA
25acth459.6CGB5, NR0B1, CDKN1C, INHA, PAM
26lutein459.5CGA, CGB5
27paraffin459.3INHA, AFP, CGB5, CGA
28steroid459.2CGA, CGB5, AFP, NR0B1, INHA
29oestriol459.1AFP, CGB5, CGA, PSG1
30estradiol45 11 2410.8PSG1, CGA, CGB5, AFP, INHA
31zinc45 249.6PSG1, CTSC, CGB5, AFP, NR0B1, PAM
32progesterone45 60 29 11 2412.6PSG1, CGA, CGB5, AFP, NR0B1, INHA

GO Terms for genes affiliated with Gestational Trophoblastic Neoplasm

Sources:
16Gene Ontology
See all sources

Cellular components related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5PAM, INHA, CGA, PSG1, PSG9, PSG6

Biological processes related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:04232610.0INHA, CDKN1C
2female pregnancyGO:0075658.0PSG1, PSG9, PSG6, CSH1

Molecular functions related to Gestational Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7INHA, CGA, CSH1

Products for genes affiliated with Gestational Trophoblastic Neoplasm

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gestational Trophoblastic Neoplasm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet