GTN
MCID: GST059
MIFTS: 26

Gestational Trophoblastic Tumor (GTN) malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Gestational Trophoblastic Tumor

Aliases & Descriptions for Gestational Trophoblastic Tumor:

Name: Gestational Trophoblastic Tumor 50 52
Gestational Trophoblastic Disease 50 69
Gestational Trophoblastic Neoplasms 69
Gestational Trophoblastic Neoplasm 50
Gtn 50

Classifications:



Summaries for Gestational Trophoblastic Tumor

MalaCards based summary : Gestational Trophoblastic Tumor, also known as gestational trophoblastic disease, is related to gestational trophoblastic neoplasm and hydatidiform mole, recurrent, 1. An important gene associated with Gestational Trophoblastic Tumor is CGB5 (Chorionic Gonadotropin Beta Subunit 5). The drugs Nitroglycerin and Chorionic Gonadotropin have been mentioned in the context of this disorder. Affiliated tissues include brain and liver, and related phenotype is Decreased homologous recombination repair frequency.

Related Diseases for Gestational Trophoblastic Tumor

Diseases related to Gestational Trophoblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
id Related Disease Score Top Affiliating Genes
1 gestational trophoblastic neoplasm 12.3
2 hydatidiform mole, recurrent, 1 11.1
3 recurrent hydatidiform mole 11.1
4 partial hydatidiform mole 10.0
5 hepatitis 9.8
6 respiratory failure 9.8
7 arteriovenous malformation 9.8
8 vaginitis 9.8
9 pulmonary tuberculosis 9.8
10 epithelioid trophoblastic tumor 9.8
11 choriocarcinoma 9.8
12 placental site trophoblastic tumor 9.8
13 hermaphroditism 9.8
14 tuberculosis 9.8
15 pancreatitis 9.8
16 pancreatic cancer 9.8
17 paroxysmal hemicrania 9.8
18 oral squamous cell carcinoma 9.8
19 squamous cell carcinoma 9.8
20 gigantomastia 9.6 CGB5 ERBB3 STARD7

Graphical network of the top 20 diseases related to Gestational Trophoblastic Tumor:



Diseases related to Gestational Trophoblastic Tumor

Symptoms & Phenotypes for Gestational Trophoblastic Tumor

GenomeRNAi Phenotypes related to Gestational Trophoblastic Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00236-A-1 8.8 ERBB3 STARD7
2 Decreased homologous recombination repair frequency GR00236-A-2 8.8 STARD7

Drugs & Therapeutics for Gestational Trophoblastic Tumor

Drugs for Gestational Trophoblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroglycerin Approved, Investigational Phase 4,Phase 2 55-63-0 4510
2 Chorionic Gonadotropin Phase 4
3
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
4
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
5
Carboplatin Approved Phase 3,Phase 1 41575-94-4 10339178 498142 38904
6
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
7
Captopril Approved Phase 3 62571-86-2 44093
8
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
9
Ribavirin Approved Phase 3 36791-04-5 37542
10
Fluconazole Approved Phase 3 86386-73-4 3365
11
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
12
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
13
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
14
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
15
Palivizumab Approved, Investigational Phase 3 188039-54-5
16
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
17
Levoleucovorin Approved Phase 2, Phase 3 68538-85-2
18
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
19
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
20
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
21
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
22
Mycophenolic acid Approved Phase 3 24280-93-1 446541
23
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
24
Norgestimate Approved Phase 3 35189-28-7 6540478
25
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
26
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
27
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
29 Liver Extracts Phase 3,Phase 2,Phase 1
30 Acyclovir Phase 3
31 valacyclovir Phase 3
32 Hydroxyitraconazole Phase 3
33 Alkylating Agents Phase 3,Phase 1
34
protease inhibitors Phase 3
35 Folic Acid Antagonists Phase 3,Phase 2
36 Steroid Synthesis Inhibitors Phase 3
37 HIV Protease Inhibitors Phase 3
38 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
39 Cytochrome P-450 CYP3A Inhibitors Phase 3
40 Hematinics Phase 3,Phase 2
41 Cytochrome P-450 Enzyme Inhibitors Phase 3
42 Topoisomerase Inhibitors Phase 3,Phase 1
43 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
44 Dermatologic Agents Phase 3,Phase 2
45 Trace Elements Phase 3,Phase 2
46 Hormone Antagonists Phase 3,Phase 2,Phase 1
47 Hormones Phase 3,Phase 2,Phase 1
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
49 Echinocandins Phase 3,Phase 2
50 Angiotensin-Converting Enzyme Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 72)
id Name Status NCT ID Phase
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole Recruiting NCT01630954 Phase 4
3 Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3
4 RCT on the Efficacy of Methotrexate for the Prevention of GTD Completed NCT01984099 Phase 3
5 Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer Completed NCT00058071 Phase 3
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
8 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
9 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
10 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
11 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3
12 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
13 Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms Recruiting NCT02606539 Phase 2, Phase 3
14 Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01823315 Phase 3
15 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01535053 Phase 3
16 Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Not yet recruiting NCT02639650 Phase 3
17 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3
18 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3
19 Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia Completed NCT00003688 Phase 2
20 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2
21 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
22 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
23 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2
26 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2
27 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2
28 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2
29 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2
30 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2
31 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2
32 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
33 Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias Recruiting NCT03135769 Phase 2
34 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2
35 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Recruiting NCT01764802 Phase 2
36 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
37 Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy Terminated NCT00096187 Phase 2
38 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
39 Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections Unknown status NCT00769613 Phase 1
40 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
41 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1
42 Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1
43 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1
44 Donor Mesenchymal Stem Cell Infusion in Treating Patients With Acute or Chronic Graft-Versus-Host Disease After Undergoing a Donor Stem Cell Transplant Completed NCT00361049 Phase 1
45 Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant Completed NCT00569283 Phase 1
46 Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy Completed NCT00509691 Phase 1
47 Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00957736 Phase 1
48 Detection of Human Chorionic Gonadotropin by Interferometry in Gestational Trophoblastic Disease Unknown status NCT00166790
49 Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant Completed NCT00293384
50 Study of the Emotional Needs of Caregivers of Stem Cell Transplantation Patients Completed NCT00082654

Search NIH Clinical Center for Gestational Trophoblastic Tumor

Genetic Tests for Gestational Trophoblastic Tumor

Anatomical Context for Gestational Trophoblastic Tumor

MalaCards organs/tissues related to Gestational Trophoblastic Tumor:

39
Brain, Liver

Publications for Gestational Trophoblastic Tumor

Articles related to Gestational Trophoblastic Tumor:

(show top 50) (show all 59)
id Title Authors Year
1
SALL4 expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. ( 27068524 )
2016
2
BEP for high-risk gestational trophoblastic tumor: results from a cohort of 45 patients. ( 26775361 )
2015
3
Current issues in the histopathology of gestational trophoblastic tumors. ( 20055562 )
2010
4
Gestational trophoblastic tumor with liver metastasis after misoprostol abortion. ( 18762963 )
2009
5
Practical issues in the management of low-risk gestational trophoblast tumors. ( 19004403 )
2008
6
[Evaluation of treatment relating to gestational trophoblastic tumor registered to the French Trophoblastic Disease Reference Center (TDRC) in Lyon from 1999 to 2005]. ( 17336125 )
2007
7
Efficacy of the FAEV regimen in the treatment of high-risk, drug-resistant gestational trophoblastic tumor. ( 17977170 )
2007
8
Gestational trophoblastic tumor in pregnancy: a case report and review of the literature. ( 16681776 )
2006
9
Gestational trophoblastic tumor at a tertiary level cancer center: a retrospective study. ( 17165433 )
2006
10
Recurrent gestational trophoblastic tumor: management and risk factors for recurrence. ( 16750258 )
2006
11
Hepatic arteriogram for gestational trophoblastic tumor: is it useful? ( 16377586 )
2005
12
Emergency craniotomy in patients with intracranial metastatic gestational trophoblastic tumor. ( 15777896 )
2005
13
Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. ( 15721402 )
2005
14
Early pregnancy outcomes after chemotherapy for gestational trophoblastic tumor. ( 15305824 )
2004
15
Diagnostic and prognostic significance of circulating tumor suppressor gene p53 autoantibodies in patients with gestational trophoblastic tumors. ( 15068319 )
2004
16
EMA/EP chemotherapy for chemorefractory gestational trophoblastic tumor. ( 15283051 )
2004
17
Management of patients with metastatic gestational trophoblastic tumor. ( 15262140 )
2004
18
Salvage chemotherapy for high-risk gestational trophoblastic tumor. ( 15283050 )
2004
19
Floxuridine-containing regimens in the treatment of gestational trophoblastic tumor. ( 15283053 )
2004
20
Angiogenin and gestational trophoblastic tumors, a promising prognostic marker. ( 12705339 )
2003
21
Successful term pregnancy after selective arterial embolization of symptomatic arteriovenous malformation in the setting of gestational trophoblastic tumor. ( 12504631 )
2003
22
[Significance of serum/cerebrospinal fluid human chorionic gonadotropin ratio and prophylactic intrathecal therapy in patients with brain metastases of gestational trophoblast tumor]. ( 14728849 )
2003
23
[18F]fluorodeoxyglucose positron emission tomography as a useful indicator of metastatic gestational trophoblastic tumor: preliminary results in three patients. ( 14529686 )
2003
24
Gestational trophoblastic tumor after medical abortion. ( 12738129 )
2003
25
Correlation of risk categorization in gestational trophoblastic tumor between old and new combined staging and scoring system. ( 12696623 )
2003
26
Risk of abnormal pregnancy completing chemotherapy for gestational trophoblastic tumor. ( 12586587 )
2003
27
Coexisting true hermaphroditism and partial hydatidiform mole developing metastatic gestational trophoblastic tumors. A case report. ( 12447683 )
2002
28
Subsequent pregnancy experience in patients with molar pregnancy and gestational trophoblastic tumor. ( 12063876 )
2002
29
Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. ( 11855880 )
2002
30
Doppler ultrasonography of the uterine artery and the response to chemotherapy in patients with gestational trophoblastic tumors. ( 12006530 )
2002
31
Pregnancy outcomes of patients who conceived within 1 year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 patients. ( 11585428 )
2001
32
[Clinical study of four cases with malignant gestation trophoblastic tumor after mifepristone abortion]. ( 11286033 )
2000
33
CSF/serum beta-hCG ratio in patients with brain metastases of gestational trophoblastic tumor. ( 10710737 )
2000
34
Guidelines for the stratification of patients recruited to trials of therapy for low-risk gestational trophoblastic tumor. ( 10926786 )
2000
35
The role of hysterectomy in the therapy of gestational trophoblastic tumor. ( 12899400 )
2000
36
Pregnancy outcome after treatment with etoposide (VP-16) for low-risk gestational trophoblastic tumor. ( 11240760 )
1999
37
Cellular immune response levels in gestational trophoblastic tumor patients after hydatidiform mole. ( 10428348 )
1999
38
Outcome of pregnancies occurring before completion of human chorionic gonadotropin follow-up in patients with persistent gestational trophoblastic tumor. ( 10366457 )
1999
39
Diagnosis and treatment of the malignant gestational trophoblastic tumor with pulmonary metastasis complicated with pulmonary tuberculosis. ( 12894897 )
1999
40
Clinical assessment of EMA/CO induced DNA damage in peripheral blood lymphocytes of high-risk gestational trophoblastic tumor patients. ( 10376437 )
1999
41
Pregnancy outcome of patients conceiving within one year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 cases. ( 11189204 )
1998
42
Changing face of gestational trophoblastic tumor. ( 9833623 )
1998
43
The role of transvaginal ultrasonography in the management of gestational trophoblastic tumor. ( 7741920 )
1995
44
Evaluation of prognostic factors and staging in gestational trophoblastic tumor. ( 7970479 )
1994
45
Brain metastases of gestational trophoblastic tumor. ( 7518516 )
1994
46
Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure. ( 8035373 )
1994
47
Liver metastases of gestational trophoblastic tumor. ( 8380786 )
1993
48
Staging rules for gestational trophoblastic tumors and fallopian tube cancer. ( 1317647 )
1992
49
Experience of human chorionic gonadotropin assays in gestational trophoblastic tumors. ( 1680961 )
1991
50
Flow cytometric analysis of DNA content in partial hydatidiform moles with persistent gestational trophoblastic tumor. ( 1845777 )
1991

Variations for Gestational Trophoblastic Tumor

Expression for Gestational Trophoblastic Tumor

Search GEO for disease gene expression data for Gestational Trophoblastic Tumor.

Pathways for Gestational Trophoblastic Tumor

GO Terms for Gestational Trophoblastic Tumor

Sources for Gestational Trophoblastic Tumor

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70 UMLS via Orphanet
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