MCID: GST059
MIFTS: 33

Gestational Trophoblastic Tumor malady

Rare diseases, Reproductive diseases, Cancer diseases categories

Summaries for Gestational Trophoblastic Tumor

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Wikipedia:63 Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours. These... more...

MalaCards based summary: Gestational Trophoblastic Tumor, also known as gestational trophoblastic disease, is related to gestational trophoblastic neoplasm and choriocarcinoma. An important gene associated with Gestational Trophoblastic Tumor is NLRP7 (NLR family, pyrin domain containing 7). The compounds 13,14-dihydro-15-ketoprostaglandin f2alpha and fundal have been mentioned in the context of this disorder. Affiliated tissues include placenta, brain and liver.

Aliases & Classifications for Gestational Trophoblastic Tumor

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Sources:
41NIH Rare Diseases, 43Novoseek, 47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Gestational Trophoblastic Tumor, Aliases & Descriptions:

Name: Gestational Trophoblastic Tumor 41 43
Gestational Trophoblastic Disease 41 43 60
Complete Hydatidiform Mole 41 47 60
Complete Molar Pregnancy 41 47
 
Gestational Trophoblastic Neoplasms 60
Gestational Trophoblastic Neoplasm 41
Hydatidiform Mole, Recurrent, 2 60
Hydatidiform Mole, Recurrent, 1 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

47
complete hydatidiform mole:
Inheritance: Autosomal recessive,Not applicable; Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Orphanet47 254688
ICD10 via Orphanet26 O01.0
UMLS via Orphanet61 C0678213

Related Diseases for Gestational Trophoblastic Tumor

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Graphical network of the top 20 diseases related to Gestational Trophoblastic Tumor:



Diseases related to gestational trophoblastic tumor

Symptoms for Gestational Trophoblastic Tumor

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Drugs & Therapeutics for Gestational Trophoblastic Tumor

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Drug clinical trials:

Search ClinicalTrials for Gestational Trophoblastic Tumor

Search NIH Clinical Center for Gestational Trophoblastic Tumor

Genetic Tests for Gestational Trophoblastic Tumor

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Anatomical Context for Gestational Trophoblastic Tumor

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MalaCards organs/tissues related to Gestational Trophoblastic Tumor:

31
Placenta, Brain, Liver

Animal Models for Gestational Trophoblastic Tumor or affiliated genes

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Publications for Gestational Trophoblastic Tumor

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Articles related to Gestational Trophoblastic Tumor:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
Current issues in the histopathology of gestational trophoblastic tumors. (20055562)
2010
2
Gestational trophoblastic tumor with liver metastasis after misoprostol abortion. (18762963)
2009
3
Practical issues in the management of low-risk gestational trophoblast tumors. (19004403)
2008
4
Evaluation of treatment relating to gestational trophoblastic tumor registered to the French Trophoblastic Disease Reference Center (TDRC) in Lyon from 1999 to 2005]. (17336125)
2007
5
Efficacy of the FAEV regimen in the treatment of high-risk, drug-resistant gestational trophoblastic tumor. (17977170)
2007
6
Gestational trophoblastic tumor at a tertiary level cancer center: a retrospective study. (17165433)
2006
7
Recurrent gestational trophoblastic tumor: management and risk factors for recurrence. (16750258)
2006
8
Gestational trophoblastic tumor in pregnancy: a case report and review of the literature. (16681776)
2006
9
Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (15721402)
2005
10
Floxuridine-containing regimens in the treatment of gestational trophoblastic tumor. (15283053)
2004
11
Early pregnancy outcomes after chemotherapy for gestational trophoblastic tumor. (15305824)
2004
12
Salvage chemotherapy for high-risk gestational trophoblastic tumor. (15283050)
2004
13
EMA/EP chemotherapy for chemorefractory gestational trophoblastic tumor. (15283051)
2004
14
Risk of abnormal pregnancy completing chemotherapy for gestational trophoblastic tumor. (12586587)
2003
15
Successful term pregnancy after selective arterial embolization of symptomatic arteriovenous malformation in the setting of gestational trophoblastic tumor. (12504631)
2003
16
Correlation of risk categorization in gestational trophoblastic tumor between old and new combined staging and scoring system. (12696623)
2003
17
Significance of serum/cerebrospinal fluid human chorionic gonadotropin ratio and prophylactic intrathecal therapy in patients with brain metastases of gestational trophoblast tumor]. (14728849)
2003
18
Gestational trophoblastic tumor after medical abortion. (12738129)
2003
19
18F]fluorodeoxyglucose positron emission tomography as a useful indicator of metastatic gestational trophoblastic tumor: preliminary results in three patients. (14529686)
2003
20
Angiogenin and gestational trophoblastic tumors, a promising prognostic marker. (12705339)
2003
21
Doppler ultrasonography of the uterine artery and the response to chemotherapy in patients with gestational trophoblastic tumors. (12006530)
2002
22
Coexisting true hermaphroditism and partial hydatidiform mole developing metastatic gestational trophoblastic tumors. A case report. (12447683)
2002
23
Subsequent pregnancy experience in patients with molar pregnancy and gestational trophoblastic tumor. (12063876)
2002
24
Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. (11855880)
2002
25
Pregnancy outcomes of patients who conceived within 1 year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 patients. (11585428)
2001
26
Guidelines for the stratification of patients recruited to trials of therapy for low-risk gestational trophoblastic tumor. (10926786)
2000
27
CSF/serum beta-hCG ratio in patients with brain metastases of gestational trophoblastic tumor. (10710737)
2000
28
The role of hysterectomy in the therapy of gestational trophoblastic tumor. (12899400)
2000
29
Clinical study of four cases with malignant gestation trophoblastic tumor after mifepristone abortion]. (11286033)
2000
30
Pregnancy outcome after treatment with etoposide (VP-16) for low-risk gestational trophoblastic tumor. (11240760)
1999
31
Clinical assessment of EMA/CO induced DNA damage in peripheral blood lymphocytes of high-risk gestational trophoblastic tumor patients. (10376437)
1999
32
Diagnosis and treatment of the malignant gestational trophoblastic tumor with pulmonary metastasis complicated with pulmonary tuberculosis. (12894897)
1999
33
Outcome of pregnancies occurring before completion of human chorionic gonadotropin follow-up in patients with persistent gestational trophoblastic tumor. (10366457)
1999
34
Cellular immune response levels in gestational trophoblastic tumor patients after hydatidiform mole. (10428348)
1999
35
Pregnancy outcome of patients conceiving within one year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 cases. (11189204)
1998
36
The role of transvaginal ultrasonography in the management of gestational trophoblastic tumor. (7741920)
1995
37
Brain metastases of gestational trophoblastic tumor. (7518516)
1994
38
Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure. (8035373)
1994
39
Evaluation of prognostic factors and staging in gestational trophoblastic tumor. (7970479)
1994
40
Liver metastases of gestational trophoblastic tumor. (8380786)
1993
41
Staging rules for gestational trophoblastic tumors and fallopian tube cancer. (1317647)
1992
42
Correlation of plasma methotrexate concentration with human chorionic gonadotropin and therapeutic response to low-dose methotrexate-citrovorum factor in low-medium-risk gestational trophoblastic tumors. (1646754)
1991
43
The role of contraception in the development of postmolar gestational trophoblastic tumor. (1648697)
1991
44
Duplex ultrasonography for persistent gestational trophoblastic tumor. (2008004)
1991
45
Experience of human chorionic gonadotropin assays in gestational trophoblastic tumors. (1680961)
1991
46
Flow cytometric analysis of DNA content in partial hydatidiform moles with persistent gestational trophoblastic tumor. (1845777)
1991
47
Persistent gestational trophoblastic tumor after partial hydatidiform mole. (2156765)
1990
48
Evaluation of management of gestational trophoblastic tumor in National Taiwan University Hospital. (2543310)
1989
49
Multidisciplinary approach in the management of gestational trophoblastic tumor (GTT). (2543312)
1989
50
Immunobiology of complete molar pregnancy and gestational trophoblastic tumor. (3030577)
1986

Variations for Gestational Trophoblastic Tumor

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Clinvar genetic disease variations for Gestational Trophoblastic Tumor:

6 (show all 15)
id Gene Variation Type Significance SNP ID Assembly Location
1NLRP7NLRP7, IVS3DS, G-A, +1single nucleotide variantPathogenic
2NLRP7NLRP7, IVS7DS, G-A, +1single nucleotide variantPathogenic
3NLRP7NM_001127255.1(NLRP7): c.2077C> T (p.Arg693Trp)single nucleotide variantPathogenicrs104895506GRCh37Chr 19, 55449464: 55449464
4NLRP7NM_001127255.1(NLRP7): c.2078G> C (p.Arg693Pro)single nucleotide variantPathogenicrs104895502GRCh37Chr 19, 55449463: 55449463
5NLRP7NM_001127255.1(NLRP7): c.2738A> G (p.Asn913Ser)single nucleotide variantPathogenicrs104895503GRCh37Chr 19, 55441939: 55441939
6NLRP7NM_001127255.1(NLRP7): c.1294C> T (p.Arg432Ter)single nucleotide variantPathogenicrs104895530GRCh37Chr 19, 55450893: 55450893
7NLRP7NLRP7, 1-BP INS, 337GinsertionPathogenic
8NLRP7NM_001127255.1(NLRP7): c.2078G> A (p.Arg693Gln)single nucleotide variantPathogenicrs104895502GRCh37Chr 19, 55449463: 55449463
9NLRP7NM_001127255.1(NLRP7): c.1193T> G (p.Leu398Arg)single nucleotide variantPathogenicrs104895548GRCh37Chr 19, 55450994: 55450994
10NLRP7NM_001127255.1(NLRP7): c.1951C> T (p.Pro651Ser)single nucleotide variantPathogenicrs104895549GRCh37Chr 19, 55449590: 55449590
11KHDC3LKDHC3L, 3G-Tsingle nucleotide variantPathogenic
12KHDC3LKDHC3L, 4-BP DEL, 322GACTdeletionPathogenic
13KHDC3LKDHC3L, 1A-Gsingle nucleotide variantPathogenic
14NLRP7NLRP7, 14-BP DUP, NT939duplicationPathogenic
15NLRP7NLRP7, 1-BP DEL, 2030TdeletionPathogenic

Expression for genes affiliated with Gestational Trophoblastic Tumor

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Search GEO for disease gene expression data for Gestational Trophoblastic Tumor.

Pathways for genes affiliated with Gestational Trophoblastic Tumor

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Compounds for genes affiliated with Gestational Trophoblastic Tumor

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Compounds related to Gestational Trophoblastic Tumor according to GeneCards Suite gene sharing:

(show all 25)
idCompoundScoreTop Affiliating Genes
113,14-dihydro-15-ketoprostaglandin f2alpha439.5CGB5, OXT
2fundal439.5CGB5, OXT
3estradiol benzoate439.5CGB5, OXT
4buserelin43 28 1211.5CGB5, OXT
5(+-)-pgf2-alpha439.5CGB5, OXT
6naloxone43 28 49 1212.4OXT, CGB5
7prostaglandin f2alpha439.4CGB5, OXT
8phenylephrine43 28 24 1212.4CGB5, OXT
9pge1439.4OXT, CGB5
10progestin439.4CGB5, OXT
11corticosterone43 59 2411.3CGB5, OXT
12mifepristone43 28 59 1212.3CGB5, OXT
13nifedipine43 28 49 1212.2CGB5, OXT
14nicotine43 28 49 1212.1OXT, CGB5
15acth439.1CGB5, OXT
16estradiol43 24 1211.0OXT, ERBB3, CGB5
17paraffin439.0CGB5, ERBB3, OXT
18forskolin43 49 1211.0CGB5, ERBB3, OXT
19progesterone43 28 59 24 1212.9CGB5, ERBB3, OXT
20testosterone43 59 24 1211.9OXT, ERBB3, CGB5
21prostaglandin438.8CGB5, OXT
22steroid438.8OXT, ERBB3, CGB5
23nitric oxide43 24 1210.7CGB5, ANG, OXT
24estrogen438.6CGB5, ERBB3, OXT
25vegf438.5OXT, ANG, ERBB3, CGB5

GO Terms for genes affiliated with Gestational Trophoblastic Tumor

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Biological processes related to Gestational Trophoblastic Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heart developmentGO:00075079.5ERBB3, OXT

Products for genes affiliated with Gestational Trophoblastic Tumor

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Sources for Gestational Trophoblastic Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet