MCID: GST059
MIFTS: 30

Gestational Trophoblastic Tumor malady

Cancer category

Summaries for Gestational Trophoblastic Tumor

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64Wikipedia, 33MalaCards
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Wikipedia:64 Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours. These... more...

MalaCards: Gestational Trophoblastic Tumor, also known as gestational trophoblastic disease, is related to gestational trophoblastic neoplasm and placental site trophoblastic tumor. An important gene associated with Gestational Trophoblastic Tumor is ERBB3 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3). The compounds 13,14-dihydro-15-ketoprostaglandin f2alpha and fundal have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver.

Aliases & Classifications for Gestational Trophoblastic Tumor

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

gestational trophoblastic tumor 43 45
gestational trophoblastic disease 43 45
gestational trophoblastic neoplasms 61
gestational trophoblastic neoplasm 43


Related Diseases for Gestational Trophoblastic Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gestational Trophoblastic Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1gestational trophoblastic neoplasm31.3CGB5, CGB
2placental site trophoblastic tumor30.3CGB5, CGB
3ectopic pregnancy30.2CGB, CGB5
4trophoblastic neoplasm10.8
5partial hydatidiform mole10.5
6invasive mole10.4
7placenta accreta10.2
8hydatidiform mole, recurrent10.2
9pulmonary tuberculosis10.2
10arteriovenous malformation10.2
11tuberculosis10.2
12epithelioid trophoblastic tumor10.2
13placental insufficiency10.2
14large cell carcinoma10.2
15uterine disease10.2
16vascular disease10.2
17triploidy10.2
18hypoxia10.2
19germ cell tumors10.2
20extragonadal germ cell tumor10.0CGB5
21cholangiocarcinoma10.0CGB
22serotonin syndrome10.0CGB
23dysgerminoma10.0CGB5
24gynecomastia10.0CGB5
25leydig cell tumor10.0CGB5
26prolactinoma10.0CGB
27infertility10.0CGB
28endodermal sinus tumor10.0CGB, CGB5
29seminoma10.0CGB, CGB5
30chorioamnionitis10.0OXT
31cryptococcosis10.0CGB, CGB5
32pregnancy loss10.0CGB5, CGB
33germinoma10.0CGB5, CGB
34diabetes insipidus10.0OXT
35hyperprolactinemia10.0CGB, CGB5
36embryonal cancer10.0CGB5, CGB
37neural tube defects10.0CGB, CGB5
38transitional cell carcinoma10.0ERBB3, CGB5, CGB
39adenocarcinoma10.0ERBB3, CGB, CGB5
40sarcoma10.0CGB5, CGB, ERBB3
41teratoma10.0CGB, CGB5
42non-small cell lung carcinoma10.0ERBB3, CGB5, CGB
43bladder carcinoma10.0ANG, CGB5, CGB
44factor v leiden thrombophilia10.0OXT, CGB, CGB5
45pre-eclampsia10.0OXT, CGB, CGB5
46ovarian cancer10.0CGB5, ERBB3, CGB, ANG
47choriocarcinoma10.0ERBB3, CGB, OXT, CGB5, STARD7

Graphical network of the top 20 diseases related to Gestational Trophoblastic Tumor:



Diseases related to gestational trophoblastic tumor

Clinical Features for Gestational Trophoblastic Tumor

Drugs & Therapeutics for Gestational Trophoblastic Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Gestational Trophoblastic Tumor

Drug clinical trials:

Search ClinicalTrials for Gestational Trophoblastic Tumor

Search NIH Clinical Center for Gestational Trophoblastic Tumor

Search CenterWatch for Gestational Trophoblastic Tumor

Genetic Tests for Gestational Trophoblastic Tumor

Anatomical Context for Gestational Trophoblastic Tumor

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33MalaCards
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MalaCards organs/tissues related to Gestational Trophoblastic Tumor:

33
Brain, Heart, Liver, Ovary, Placenta

Animal Models for Gestational Trophoblastic Tumor or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Gestational Trophoblastic Tumor

Sources:
51PubMed
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Articles related to Gestational Trophoblastic Tumor:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Metastatic gestational trophoblastic neoplasia complicated by tumor lysis syndrome, heart failure, and thyrotoxicosis: a case report. (21043373)
2010
2
Sonographic appearance of gestational trophoblastic disease evolving into epithelioid trophoblastic tumor. (20069561)
2010
3
Gestational trophoblastic tumor with liver metastasis after misoprostol abortion. (18762963)
2009
4
Expression of laminin receptor 1 in gestational trophoblastic diseases and normal placenta and its relationship with the development of postmolar tumors. (19481788)
2009
5
Clinical value of tumor markers in gestational trophoblastic diseases. (19160651)
2008
6
Non-gestational malignant placental site trophoblastic tumor of the ovary in a 4-year-old rhesus monkey. (18487497)
2008
7
Determination of hyperglycosylated human chorionic gonadotropin produced by malignant gestational trophoblastic neoplasias and male germ cell tumors using a lectin-based immunoassay and surface plasmon resonance. (17081681)
2007
8
Evaluation of treatment relating to gestational trophoblastic tumor registered to the French Trophoblastic Disease Reference Center (TDRC) in Lyon from 1999 to 2005]. (17336125)
2007
9
Efficacy of the FAEV regimen in the treatment of high-risk, drug-resistant gestational trophoblastic tumor. (17977170)
2007
10
Gestational trophoblastic tumor at a tertiary level cancer center: a retrospective study. (17165433)
2006
11
Recurrent gestational trophoblastic tumor: management and risk factors for recurrence. (16750258)
2006
12
Gestational trophoblastic tumor in pregnancy: a case report and review of the literature. (16681776)
2006
13
Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (15721402)
2005
14
Hepatic arteriogram for gestational trophoblastic tumor: is it useful? (16377586)
2005
15
Emergency craniotomy in patients with intracranial metastatic gestational trophoblastic tumor. (15777896)
2005
16
Floxuridine-containing regimens in the treatment of gestational trophoblastic tumor. (15283053)
2004
17
Early pregnancy outcomes after chemotherapy for gestational trophoblastic tumor. (15305824)
2004
18
Salvage chemotherapy for high-risk gestational trophoblastic tumor. (15283050)
2004
19
EMA/EP chemotherapy for chemorefractory gestational trophoblastic tumor. (15283051)
2004
20
Management of patients with metastatic gestational trophoblastic tumor. (15262140)
2004
21
Risk of abnormal pregnancy completing chemotherapy for gestational trophoblastic tumor. (12586587)
2003
22
Successful term pregnancy after selective arterial embolization of symptomatic arteriovenous malformation in the setting of gestational trophoblastic tumor. (12504631)
2003
23
Gestational trophoblastic tumor after medical abortion. (12738129)
2003
24
18F]fluorodeoxyglucose positron emission tomography as a useful indicator of metastatic gestational trophoblastic tumor: preliminary results in three patients. (14529686)
2003
25
Doppler ultrasonography of the uterine artery and the response to chemotherapy in patients with gestational trophoblastic tumors. (12006530)
2002
26
Pregnancy outcomes of patients who conceived within 1 year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 patients. (11585428)
2001
27
Guidelines for the stratification of patients recruited to trials of therapy for low-risk gestational trophoblastic tumor. (10926786)
2000
28
CSF/serum beta-hCG ratio in patients with brain metastases of gestational trophoblastic tumor. (10710737)
2000
29
The role of hysterectomy in the therapy of gestational trophoblastic tumor. (12899400)
2000
30
Expression of epidermal growth factor receptor-related family products in gestational trophoblastic diseases and normal placenta and its relationship with development of postmolar tumor. (10831347)
2000
31
Clinical assessment of EMA/CO induced DNA damage in peripheral blood lymphocytes of high-risk gestational trophoblastic tumor patients. (10376437)
1999
32
Diagnosis and treatment of the malignant gestational trophoblastic tumor with pulmonary metastasis complicated with pulmonary tuberculosis. (12894897)
1999
33
Outcome of pregnancies occurring before completion of human chorionic gonadotropin follow-up in patients with persistent gestational trophoblastic tumor. (10366457)
1999
34
Cellular immune response levels in gestational trophoblastic tumor patients after hydatidiform mole. (10428348)
1999
35
Pregnancy outcome of patients conceiving within one year after chemotherapy for gestational trophoblastic tumor: a clinical report of 22 cases. (11189204)
1998
36
Differential expression of a tumor necrosis factor receptor-related transcript in gestational trophoblastic diseases in women. (9716562)
1998
37
Changing face of gestational trophoblastic tumor. (9833623)
1998
38
Placental-site trophoblastic tumor following metastatic gestational trophoblastic neoplasia. (8910639)
1996
39
The role of transvaginal ultrasonography in the management of gestational trophoblastic tumor. (7741920)
1995
40
Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure. (8035373)
1994
41
Staging rules for gestational trophoblastic tumors and fallopian tube cancer. (1317647)
1992
42
Correlation of plasma methotrexate concentration with human chorionic gonadotropin and therapeutic response to low-dose methotrexate-citrovorum factor in low-medium-risk gestational trophoblastic tumors. (1646754)
1991
43
Invasive mole and placental site trophoblastic tumor. Two entities of gestational trophoblastic disease with a common ultrasonographic appearance. (1656062)
1991
44
Duplex ultrasonography for persistent gestational trophoblastic tumor. (2008004)
1991
45
Experience of human chorionic gonadotropin assays in gestational trophoblastic tumors. (1680961)
1991
46
Flow cytometric analysis of DNA content in partial hydatidiform moles with persistent gestational trophoblastic tumor. (1845777)
1991
47
Evaluation of management of gestational trophoblastic tumor in National Taiwan University Hospital. (2543310)
1989
48
EMA/CO regimen in high-risk gestational trophoblastic tumor (GTT). (2846414)
1988
49
Methotrexate with citrovorum factor in low-risk gestational trophoblastic tumor. (3037744)
1987
50
Immunobiology of complete molar pregnancy and gestational trophoblastic tumor. (3030577)
1986

Genetic Variations for Gestational Trophoblastic Tumor

Expression for genes affiliated with Gestational Trophoblastic Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gestational Trophoblastic Tumor

Search GEO for disease gene expression data for Gestational Trophoblastic Tumor.

Pathways for genes affiliated with Gestational Trophoblastic Tumor

Compounds for genes affiliated with Gestational Trophoblastic Tumor

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience
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Compounds related to Gestational Trophoblastic Tumor according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
113,14-dihydro-15-ketoprostaglandin f2alpha459.5OXT, CGB5
2fundal459.5OXT, CGB5
3oestriol459.5CGB, CGB5
4estradiol benzoate459.5OXT, CGB5
5buserelin45 29 1111.5CGB5, OXT
6ctp459.5CGB, CGB5
7clomiphene citrate459.4CGB5, CGB
8(+-)-pgf2-alpha459.4OXT, CGB5
9ifosfamide45 1110.4CGB, CGB5
10leucovorin45 50 1111.4CGB, CGB5
11naloxone45 50 29 1112.4OXT, CGB5
12prostaglandin f2alpha459.3CGB5, OXT
13phenylephrine45 29 11 2412.3OXT, CGB5
14pge1459.2OXT, CGB5
15bleomycin45 1110.2CGB5, CGB
16androstenedione45 2410.1CGB, CGB5
17progestin459.0OXT, CGB5
18paraffin459.0ERBB3, OXT, CGB5
19forskolin45 50 1111.0CGB5, OXT, ERBB3
20mifepristone45 60 29 1112.0CGB5, CGB, OXT
21methotrexate45 50 1110.9OXT, CGB, CGB5
22gnrh458.9CGB5, CGB, OXT
23corticosterone45 60 2410.8CGB5, OXT
24lactate458.8OXT, CGB, CGB5
25creatinine458.8OXT, CGB, CGB5
26steroid458.7ERBB3, OXT, CGB5
27estradiol45 11 2410.6CGB5, CGB, OXT, ERBB3
28progesterone45 60 29 11 2412.6CGB5, CGB, OXT, ERBB3
29testosterone45 60 11 2411.6ERBB3, OXT, CGB, CGB5
30vegf458.1ERBB3, OXT, ANG, CGB, CGB5

GO Terms for genes affiliated with Gestational Trophoblastic Tumor

Products for genes affiliated with Gestational Trophoblastic Tumor

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gestational Trophoblastic Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet