MCID: GNT008
MIFTS: 52

Giant Cell Tumor malady

Summaries for Giant Cell Tumor

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Giant-cell tumor of the bone (GCTOB) is a relatively uncommon tumor of the bone. It is characterized by... more...

MalaCards: Giant Cell Tumor, also known as giant cell tumors, is related to pigmented villonodular synovitis and synovitis. An important gene associated with Giant Cell Tumor is DES (desmin), and among its related pathways are Osteoclast differentiation and BAFF in B-Cell Signaling. The compounds calcium and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and skeleton.

Aliases & Classifications for Giant Cell Tumor

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

giant cell tumor 8 10
giant cell tumors 8 45 61
tumor of the giant cell 8
giant cell tumor nos 8
giant cell neoplasm 8


External Ids:

Disease Ontology8 DOID:200
MeSH35 D005870
NCIt40 C7069, C3055

Related Diseases for Giant Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Giant Cell Tumor family:

malignant giant cell tumor

Diseases related to Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.1CSF1
2synovitis31.0TNFSF11, TNFRSF11B
3adenocarcinoma30.4CCNA2, CA2, CALB2, TNFSF11, PLAUR, ACTC1
4bone carcinoma30.4CEACAM3, TNFRSF11B, TNFSF11, TNFRSF11A, CSF1
5cherubism30.4CALCA, TNFSF11
6giant cell reparative granuloma30.4CALCA, TNFRSF11A
7bladder carcinoma30.2CCNA2, CSF1, PLAUR
8primary hyperparathyroidism30.2CALCA, FGF23, ACP5
9squamous cell carcinoma30.2CCNA2, CALB2, PLAUR, ACTC1, SERPINA3, CEACAM3
10osteoarthritis30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK
11arthritis30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK
12hypercalcemia30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, FGF23
13fibrous histiocytoma30.0S100B, DES, ACTC1, SERPINA3
14adenoma30.0CCNA2, CALCA, CALB2, ACTC1, CEACAM3
15dermatofibrosarcoma protuberans30.0ACTC1, DES, S100B
16microphthalmia30.0S100B, TNFSF11, ACTC1, ACP5
17spindle cell sarcoma30.0S100B, DES, ACTC1
18pleomorphic adenoma30.0S100B, DES, ACTC1
19osteomalacia30.0FGF23, TNFRSF11B, CALCA
20spindle cell carcinoma30.0ACTC1, DES
21thyroid cancer30.0PLAUR, TNFRSF11B, CALCA
22bone giant cell tumor11.2
23tenosynovial giant cell tumor10.9
24villonodular synovitis10.7
25bone giant cell sarcoma10.4
26tuberous sclerosis10.4
27nodular tenosynovitis10.4
28mucinous cystadenocarcinoma10.4
29tuberous sclerosis complex10.4
30osteoblastoma10.3
31osteoclast-like giant cell neoplasm of the pancreas10.3
32chondroblastoma10.3
33osteitis fibrosa10.3
34malignant giant cell tumor of the tendon sheath10.2
35malignant giant cell tumor of soft parts10.2
36pleomorphic carcinoma10.2
37giant hemangioma10.2
38bone osteosarcoma10.2
39aneurysmal bone cysts10.2
40bone fracture10.0
41neurofibromatosis10.0
42acute pancreatitis10.0
43ossifying fibroma10.0
44ulnar neuropathy10.0
45obstructive jaundice10.0
46amelanotic melanoma10.0
47bone leiomyosarcoma10.0
48noonan syndrome10.0
49dermatofibrosarcoma10.0
50carpal tunnel syndrome10.0

Graphical network of the top 20 diseases related to Giant Cell Tumor:



Diseases related to giant cell tumor

Clinical Features for Giant Cell Tumor

Drugs & Therapeutics for Giant Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Giant Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Giant Cell Tumor

Search NIH Clinical Center for Giant Cell Tumor

Search CenterWatch for Giant Cell Tumor

Genetic Tests for Giant Cell Tumor

Anatomical Context for Giant Cell Tumor

Animal Models for Giant Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Giant Cell Tumor

Sources:
51PubMed
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Articles related to Giant Cell Tumor:

(show top 50)    (show all 759)
idTitleAuthorsYear
1
Giant cell tumor of the larynx: a case of malignant sarcomatous transformation. (23780608)
2013
2
Sustained autocrine induction and impaired negative feedback of osteoclastogenesis in CD14(+) cells of giant cell tumor of bone. (23395086)
2013
3
Unusual presentation of giant cell tumor originating from a facet joint of the thoracic spine in a child: a case report and review of the literature. (23830026)
2013
4
Giant cell tumor of the tendon sheath in the foot and ankle: case series and review of the literature. (23085383)
2013
5
Intralesional excision versus wide resection for giant cell tumor involving the acetabulum: which is better? (22125245)
2012
6
A case of giant cell tumor of sacrum with unusual pulmonary metastases: CT and FDG PET findings. (22889794)
2012
7
Giant cell tumor of bone mimicking metastatic renal cell carcinoma: a case report. (21698786)
2012
8
Tenosynovial giant cell tumor: case report and review. (22849738)
2012
9
Aggressive squamous cell carcinoma of the oral tongue in a woman with metastatic giant cell tumor treated with pegylated liposomal doxorubicin. (23263922)
2012
10
Clinical and cytogenetic aspects of giant cell tumor of the sternum. (21915509)
2011
11
Radiotherapy for marginally resected, unresectable or recurrent giant cell tumor of the bone: a rare cancer network study. (22355503)
2011
12
A strange giant cell tumor. (20888717)
2011
13
AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone. (21461405)
2011
14
Recurrent acute pancreatitis and persistent hyperamylasemia as a presentation of pancreatic osteoclastic giant cell tumor: an unusual presentation of a rare tumor. (21311208)
2011
15
Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines. (20048108)
2010
16
Silencing of the UCHL1 gene in giant cell tumors of bone. (20104524)
2010
17
Vascular solitary fibrous tumor with "floret" cells or giant cell angiofibroma? A lingual example highlighting the overlapping characteristics of these entities and positive immunoreaction for estrogen and progesterone receptors. (19272802)
2009
18
Combined hepatocellular carcinoma and osteoclast-like giant cell tumor of the liver: possible clue to histogenesis. (19883433)
2009
19
Cytomorphologic spectrum of giant cell tumor of tendon sheath. (18499987)
2008
20
Giant cell tumor of bone with secondary aneurysmal bone cyst. (20300319)
2008
21
Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of literature. (17669658)
2007
22
Giant cell tumor of the rib. (16883463)
2006
23
Successful pregnancy outcome with elective caesarean section following two attempts of surgical excision of large giant cell tumor of the lower limb during pregnancy. (16770589)
2006
24
Giant cell tumor of the distal phalanx of the foot. (16613755)
2006
25
The case. Giant-cell tumor. (16485448)
2006
26
Osteosarcoma arising from giant cell tumor of bone ten years after primary surgery: a case report and review of the literature. (16434839)
2006
27
Osteoclast-like giant cell tumor of the pancreas associated with mucus-secreting adenocarcinoma. Case report and discussion of the histogenesis. (15849490)
2005
28
Mixed osteoclastic/pleomorphic giant cell tumor of the pancreas: a case report. (16334035)
2005
29
Cathepsin K is the principal protease in giant cell tumor of bone. (15277232)
2004
30
Gene expression of osteoprotegerin and osteoclast differentiation factor in giant cell tumor. (12419159)
2002
31
Composite tumor consisting of dermatofibrosarcoma protuberans and giant cell fibroblastoma associated with intratumoral endometriosis. Report of a case. (11358013)
2001
32
Primary giant cell tumor of soft tissues similar to bone giant cell tumor: A case report and literature review. (11148467)
2001
33
Biological behavior and tumorigenesis of subependymal giant cell astrocytomas. (11519851)
2001
34
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
35
A case of hyalinizing spindle cell tumor with giant rosettes in the presacral region. Immunohistochemical and ultrastructural study]. (10051917)
1998
36
Prognostic relevance of C-myc gene expression in giant-cell tumor of bone. (9565066)
1998
37
The expression of mRNA for insulin-like growth factors and their receptor in giant cell tumors of human bone. (8542699)
1996
38
Giant cell tumor arising in Paget's disease of bone. Recurrences after 36 years. (8339495)
1993
39
Telomeric associations and consistent growth factor overexpression detected in giant cell tumor of bone. (1756472)
1991
40
Giant cell tumor of the tendon sheath (nodular tenosynovitis). A study of 207 cases to compare the large joint group with the common digit group. (3943019)
1986
41
Giant cell tumor of tendon sheath (localized nodular tenosynovitis). (6497267)
1984
42
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
43
Malignant giant cell tumor of the frontal bone. (6585707)
1984
44
A comparison of canine giant cell tumor and giant cell reparative granuloma of bone. (6836877)
1983
45
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. (6937839)
1981
46
Massive peripheral giant-cell reparative granuloma of the jaw: a pregnancy dependent tumor. (715872)
1978
47
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
48
Malignant giant cell tumor in a dog. (914686)
1977
49
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. II. Osseous and fibro-osseous lesions, including osteoma, fibrous dysplasia, ossifying fibroma, osteoblastoma, giant cell tumor, and osteosarcoma. (4207295)
1974
50
TUMOR clinic conference: giant cell epulis of the gum, with questionable malignant change. (14821950)
1951

Genetic Variations for Giant Cell Tumor

Expression for genes affiliated with Giant Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Giant Cell Tumor

Search GEO for disease gene expression data for Giant Cell Tumor.

Pathways for genes affiliated with Giant Cell Tumor

Sources:
30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Giant Cell Tumor

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Giant Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.2TNFRSF11A, DES, CTSK, TNFRSF11B, TNFSF11, S100B
2tyrosine4511.2CEACAM3, PTPRC, ACP5, ACTC1, PLAUR, TNFRSF11A
3oxygen45 2412.1TNFRSF11A, S100B, CEACAM3, CA2, CCNA2, ACP5
4paraffin4511.1PLAUR, MYOG, DES, TNFSF11, CSF1, S100B
5vegf4511.1TNFSF11, CSF1, S100B, CALCA, CCNA2, ACTC1
6steroid4511.1MYOG, TNFSF11, S100B, CALB2, CA2, CCNA2
7nitric oxide45 11 2413.1TNFRSF11B, TNFSF11, DES, MYOG, TNFRSF11A, CEACAM3
8creatinine4511.1CEACAM3, SERPINA3, ACTC1, PLAUR, FGF23, TNFRSF11B
9testosterone45 60 11 2414.1S100B, CCNA2, ACTC1, CALCA, CALB2, CSF1
10serine4511.1FGF23, MYOG, SERPINA3, CTSK, TNFRSF11B, TNFRSF11A
11cysteine4511.1CA2, S100B, DES, CSF1, MYOG, ACP5
12heparin45 29 11 2414.1PTPRC, FGF23, DES, TNFRSF11B, TNFSF11, CSF1
13calcitriol45 60 11 2414.0TNFSF11, CALCA, CA2, CSF1, TNFRSF11B, FGF23
14retinoic acid45 2412.0PLAUR, TNFRSF11B, CTSK, MYOG, DES, CA2
15progesterone45 60 29 11 2415.0PTPRC, CSF1, CCNA2, CALB2, TNFRSF11B, DES
16hydroxyapatite4511.0FGF23, CTSK, TNFRSF11B, TNFSF11, TNFRSF11A, S100B
17lipid4511.0CA2, S100B, TNFRSF11A, TNFSF11, TNFRSF11B, SERPINA3
18dexamethasone45 50 29 1114.0S100B, ACP5, TNFSF11, PTPRC, TNFRSF11B, PLAUR
191,25 dihydroxy vitamin d34511.0CALCA, TNFRSF11A, ACP5, FGF23, TNFRSF11B, TNFSF11
20b 7234511.0CALB2, ACTC1, DES, S100B, PTPRC, CEACAM3
21tartrate4511.0ACP5, TNFSF11, CSF1, CALCA, CTSK
22estrogen4511.0CA2, CALB2, MYOG
23cyclosporin a45 29 6012.9PTPRC, ACP5, TNFRSF11B, ACTC1, TNFSF11, S100B
24mucicarmine4510.9DES, S100B, ACTC1, CEACAM3, CALB2
25hematoxylin4510.9CEACAM3, DES, PTPRC, S100B, ACTC1, CALB2
26denosumab45 1111.9TNFSF11, TNFRSF11A, CALCA, TNFRSF11B
27hydrogen45 2411.9TNFSF11, S100B, CEACAM3, ACP5, PTPRC, CTSK
28teriparatide45 1111.9CTSK, TNFRSF11B, CALCA, TNFSF11
29polyethylene4510.9TNFSF11, TNFRSF11B, TNFRSF11A, CTSK
3025-hydroxyvitamin d4510.9TNFRSF11B, CALCA, TNFSF11, FGF23, ACP5
31phosphorus4510.9TNFSF11, FGF23, ACP5, CALCA, TNFRSF11B
32vitamin k24510.9TNFRSF11B, TNFSF11, CSF1, CALCA
33aspartate4510.9CA2, CTSK, ACP5, CEACAM3, CCNA2
34celecoxib45 60 29 50 11 2415.8TNFRSF11B, TNFSF11, CSF1, CA2, CCNA2
35clodronate45 50 1112.8CALCA, TNFSF11, TNFRSF11B, ACP5
36acetylcholine45 50 29 11 2414.8CALB2, MYOG, SERPINA3, CALCA
37forskolin45 50 1112.8CCNA2, PLAUR, MYOG, TNFRSF11B, TNFSF11, S100B
38pmma4510.8CALCA, TNFSF11, TNFRSF11B, ACP5
39iron45 2411.8SERPINA3, S100B, ACTC1, PLAUR, ACP5, DES
40procollagen4510.8ACP5, TNFSF11
41glucose4510.8MYOG, PLAUR, ACTC1, SERPINA3, CEACAM3
42gp 1304510.8TNFSF11, TNFRSF11B, PLAUR, CSF1, TNFRSF11A
43zoledronic acid4510.7TNFRSF11B, CALCA, TNFSF11, CTSK
44deoxypyridinoline4510.7CALCA, TNFSF11, ACP5, TNFRSF11B
45strontium ranelate4510.6CTSK, CALCA, TNFSF11
46arginine4510.6SERPINA3, CSF1, DES, FGF23, PLAUR, S100B
47superoxide45 2411.6PTPRC, SERPINA3
48alendronate45 50 1112.5ATP6V1A, TNFRSF11B, CALCA, TNFSF11
49thymidine45 2411.5CEACAM3, PLAUR, DES, CSF1, S100B, CALB2
50orcein4510.2DES, ACTC1, S100B

GO Terms for genes affiliated with Giant Cell Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6S100B, TNFSF11, TNFRSF11B, CTSK, FGF23, PLAUR
2extracellular spaceGO:00561510.3SERPINA3, CALCA, CA2, S100B, CSF1, TNFSF11

Biological processes related to Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1ossificationGO:00150310.8MYOG, TNFSF11, TNFRSF11A, CSF1
2positive regulation of osteoclast differentiationGO:04567210.8CA2, CSF1, TNFSF11
3monocyte chemotaxisGO:00254810.8CALCA, TNFRSF11A, TNFSF11
4bone resorptionGO:04545310.7ACP5, CTSK, TNFSF11
5osteoclast differentiationGO:03031610.7CSF1, TNFRSF11A, TNFSF11
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.7TNFSF11, TNFRSF11A
7TNFSF11-mediated signaling pathwayGO:07184710.7TNFSF11, TNFRSF11A
8positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.6TNFSF11, TNFRSF11A
9osteoclast proliferationGO:00215810.6TNFSF11
10mammary gland alveolus developmentGO:06074910.5TNFSF11, TNFRSF11A
11negative regulation of bone resorptionGO:04577910.5CALCA, TNFRSF11B
12positive regulation of macrophage differentiationGO:04565110.4CSF1, CALCA
13positive regulation of bone resorptionGO:04578010.2TNFSF11, CA2

Products for genes affiliated with Giant Cell Tumor

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Sources for Giant Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet