MCID: GNT008
MIFTS: 47

Giant Cell Tumor malady

Cancer diseases category

Aliases & Classifications for Giant Cell Tumor

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
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Giant Cell Tumor, Aliases & Descriptions:

Name: Giant Cell Tumor 9 11
Giant Cell Tumors 9 43 60
Tumor of the Giant Cell 9
 
Carcinoma Giant Cell 43
Giant Cell Tumor Nos 9
Giant Cell Neoplasm 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:200
NCIt38 C7069, C3055
MeSH33 D005870

Summaries for Giant Cell Tumor

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MalaCards based summary: Giant Cell Tumor, also known as giant cell tumors, is related to pigmented villonodular synovitis and fibroma. An important gene associated with Giant Cell Tumor is DES (desmin), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and GADD45 Pathway. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include bone, pancreas and salivary gland, and related mouse phenotypes are limbs/digits/tail and cardiovascular system.

Related Diseases for Giant Cell Tumor

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Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.9CSF1
2fibroma31.0DES, ACTC1
3chordoma30.6DES, S100B
4spindle cell sarcoma30.5S100B, ACTC1, DES
5dermatofibrosarcoma protuberans30.5DES, ACTC1, S100B
6fibrous histiocytoma30.5DES, ACTC1, S100B
7pleomorphic adenoma30.5DES, ACTC1, S100B
8microphthalmia30.5S100B, ACP5, ACTC1
9hemangioma30.4NF1, ACTC1, CLU
10hyperparathyroidism30.3FGF3, NF1, ACP5
11fibrosarcoma30.3ACTC1, CLU, DES
12neurofibromatosis30.3NF1, S100B
13leiomyosarcoma30.2S100B, ACTC1, TP53, DES
14myeloma30.2CCNA2, ACP5, CSF1
15osteoarthritis30.0CLU, ACP5, CSF1
16adenocarcinoma29.9ACTC1, CCNA2, CLU, TP53
17arthritis29.9CLU, ACP5, CSF1
18adenoma29.7TP53, CCNA2, ACTC1, FGF3
19hepatocellular carcinoma29.4TP53, CLU, CCNA2, ACP5, FGF3
20sarcoma29.3DES, TP53, CLU, CCNA2, ACTC1, CSF1
21melanoma28.7DES, TP53, CCNA2, ACTC1, CSF1, S100B
22tenosynovial giant cell tumor11.0
23malignant giant cell tumor11.0
24synovitis10.7
25villonodular synovitis10.7
26malignant giant cell tumor of soft parts10.6
27bone giant cell tumor10.6
28infantile myofibromatosis10.5DES
29histiocytosis10.5S100B
30aneurysmal bone cysts10.5
31malignant giant cell tumor of the tendon sheath10.5
32aneurysm10.5
33fasciitis10.5ACTC1
34fibrous meningioma10.5S100B
35gemistocytic astrocytoma10.5S100B
36syringoma10.5S100B
37tuberous sclerosis10.5
38cervicitis10.5
39ganglioglioma10.5S100B
40nodular tenosynovitis10.4
41cystadenocarcinoma10.4
42glomus tumor10.4DES, ACTC1
43epithelioid leiomyosarcoma10.4DES, ACTC1
44pseudosarcomatous fibromatosis10.4ACTC1, DES
45mucinous cystadenocarcinoma10.4
46spindle cell carcinoma10.4ACTC1, DES
47desmoid disease, hereditary10.4ACTC1, DES
48adenosarcoma10.4DES, ACTC1
49osteoclast-like giant cell neoplasm of the pancreas10.4
50rhabdoid tumor10.4ACTC1, DES

Graphical network of the top 20 diseases related to Giant Cell Tumor:



Diseases related to giant cell tumor

Symptoms for Giant Cell Tumor

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Drugs & Therapeutics for Giant Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Giant Cell Tumor

Search NIH Clinical Center for Giant Cell Tumor

Genetic Tests for Giant Cell Tumor

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Anatomical Context for Giant Cell Tumor

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MalaCards organs/tissues related to Giant Cell Tumor:

31
Bone, Pancreas, Salivary gland, Uterus, Lung, Breast, Skin, Lymph node, Spinal cord, Monocytes, Kidney, Liver, Thyroid, Ovary, Prostate, T cells, Tongue, Bone marrow

Animal Models for Giant Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Giant Cell Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.9TP53, ACP5, CSF1, NF1, FGF3
2MP:00053857.7DES, TP53, CLU, ACTC1, CSF1, NF1
3MP:00053867.6DES, TP53, CSF1, S100B, NF1, FGF3
4MP:00028737.6TP53, ACTC1, S100B, NF1, FGF3
5MP:00053907.5TP53, ACP5, COL6A3, CSF1, NF1, FGF3
6MP:00053787.4FGF3, NF1, CSF1, COL6A3, ACTC1, TP53
7MP:00053697.3NF1, DES, TP53, CLU, ACTC1, COL6A3
8MP:00053877.3TP53, CLU, CCNA2, ACP5, CSF1, NF1
9MP:00107687.1DES, TP53, CCNA2, ACTC1, CSF1, NF1

Publications for Giant Cell Tumor

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Articles related to Giant Cell Tumor:

(show top 50)    (show all 727)
idTitleAuthorsYear
1
Fibular giant cell-rich osteosarcoma virtually indistinguishable radiographically and histopathologically from giant cell tumor-analysis of subtle differentiating features. (25907659)
2015
2
Giant cell tumor of bone. (25378541)
2014
3
Computer assisted histomorphologic comparision and the expression of AgNORs in the central and peripheral giant cell lesions of the oral cavity and giant cell tumor of the long bone. (25364180)
2014
4
MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13. (24360951)
2013
5
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. (23430345)
2013
6
A misdiagnosis led to an extensive skull base surgery: infratemporal tuberculosis mimicking giant cell tumor. (24381928)
2013
7
Transarterial embolization (TAE) of sacral giant cell Tumor (GCT) using spherical parmanent embolic material superabsorbant polymer microsphere (SAP-MS). (24353982)
2013
8
Endoscopic endonasal approach for the treatment of a large clival giant cell tumor complicated by an intraoperative internal carotid artery rupture. (23403482)
2013
9
Salivary gland pleomorphic adenoma with giant cell tumor component. (23349467)
2013
10
Giant cell tumor of the distal ulna: a case report. (22657940)
2012
11
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
12
RANKL, denosumab, and giant cell tumor of bone. (22581354)
2012
13
Oncogenic osteomalacia from nasal cavity giant cell tumor. (22311466)
2012
14
Intralesional excision versus wide resection for giant cell tumor involving the acetabulum: which is better? (22125245)
2012
15
Custom made tumor-prosthesis as a primary treatment for giant cell tumor of femur--case report. (21393650)
2011
16
Distal radioulnar joint prosthesis for the treatment of giant cell tumor of the distal ulna: a case report and literature review. (21773775)
2011
17
The management of subependymal giant cell tumors in tuberous sclerosis: a clinician's perspective. (21305305)
2011
18
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. (21924561)
2011
19
Giant cell tumor of the pes anserine bursa (extra-articular pigmented villonodular bursitis): a case report and review of the literature. (21687595)
2011
20
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
21
Giant-cell tumor of the fourth metacarpal bone in children: case report. (19898253)
2010
22
Multiple giant cell tumors in maxilla and skull complicating Paget's disease of bone. (21319038)
2010
23
Fatal lung metastasis secondary to index finger giant cell tumor in an 8-year-old child. (20488151)
2010
24
Giant cell tumor of the thoracic spine: case report and review of the literature. (18207522)
2009
25
Infiltrating giant cell tumor in a case of Paget's disease of bone. (20234860)
2009
26
Wide resection and stabilization of ulnar stump by extensor carpi ulnaris for giant cell tumor of distal ulna: two case reports. (19830093)
2009
27
Giant cell tumor of the EDL tendon sheath: an unusual cause of hallux valgus. (18510911)
2008
28
Primary giant cell tumor of soft tissue in the finger. (18713588)
2008
29
Giant cell tumor of the nasal cavity: case report. (16977452)
2007
30
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
31
Giant cell tumor of the rib. (16883463)
2006
32
RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone. (16939392)
2006
33
Diffuse-type giant cell tumor. (16641758)
2006
34
Use of short implants for functional restoration of the mandible after giant cell tumor removal. Case report. (16688107)
2006
35
Morselized and structural cortical allograft reconstruction after intralesional curettage of a distal femoral giant-cell tumor. (16924858)
2006
36
Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor. (15923579)
2005
37
Giant cell tumors: inquiry into immunohistochemical expression of CD117 (c-Kit), microphthalmia transcription factor, tartrate-resistant acid phosphatase, and HAM-56. (15737031)
2005
38
Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of bone. (15193543)
2004
39
Metatarsal giant cell tumors and giant cell reparative granuloma are similar entities. (14646771)
2003
40
RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. (11863217)
2002
41
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
42
Downregulation of glutamate receptor subunit 2(3) in subependymal giant-cell tumor. (10963968)
2000
43
Diffuse variant tenosynovial giant cell tumor of the temporomandibular joint: report of a case. (9710197)
1998
44
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. (7689482)
1993
45
Cherubism: diagnosis, treatment, and comparison with central giant cell granulomas and giant cell tumors. (1545971)
1992
46
Telomeric associations and consistent growth factor overexpression detected in giant cell tumor of bone. (1756472)
1991
47
Osteoclast-like giant cell tumor of the pancreas: immunophenotypic similarity to giant cell tumor of bone. (1864595)
1991
48
Malignant giant cell tumor of tendon sheath. Report of a case. (2994359)
1985
49
Benign giant cell tumor or localized osteitis fibrosa cystica. (14846598)
1950
50
VON RECKLINGHAUSEN'S DISEASE OR OSTEITIS FIBROSA: WITH REPORT OF A CASE PRESENTING MULTIPLE CYSTS AND GIANT-CELL TUMORS. (17864590)
1922

Variations for Giant Cell Tumor

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Expression for genes affiliated with Giant Cell Tumor

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Search GEO for disease gene expression data for Giant Cell Tumor.

Pathways for genes affiliated with Giant Cell Tumor

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Pathways related to Giant Cell Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CCNA2, TP53
29.2CCNA2, TP53
3
Show member pathways
9.0FGF3, NF1, CSF1
4
Show member pathways
Signaling Pathways in Glioblastoma36
8.5TP53, NF1, FGF3
5
Show member pathways
MAPK signaling pathway36
8.5TP53, NF1, FGF3
68.3FGF3, CSF1, COL6A3, TP53
7
Show member pathways
7.9DES, TP53, COL6A3, CSF1, NF1

Compounds for genes affiliated with Giant Cell Tumor

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Compounds related to Giant Cell Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1orcein4310.0S100B, ACTC1, DES
2s 1004310.0DES, ACTC1, S100B
3reticulin4310.0S100B, ACTC1, DES
4mucicarmine4310.0DES, ACTC1, S100B
5b 723439.9DES, ACTC1, S100B
6hematoxylin439.9S100B, ACTC1, DES
7procollagen439.8ACP5, ACTC1, DES
8biotin43 24 1211.6DES, ACTC1, CSF1
9imatinib43 49 1211.6DES, ACTC1, CSF1, S100B
10bromodeoxyuridine439.5DES, CCNA2, ACP5, S100B
11iron43 2410.4S100B, ACP5, ACTC1, DES
121,25 dihydroxy vitamin d3439.3CLU, ACP5, CSF1
13cyclosporin a43 28 5911.3CCNA2, ACTC1, ACP5, S100B
14creatinine439.2S100B, CSF1, ACP5, ACTC1, DES
15adpribose439.2DES, TP53, CCNA2
16glycogen43 2410.2S100B, CSF1, ACTC1, CCNA2, DES
17estradiol43 24 1211.2ACP5, CCNA2, CLU, DES
18hydroxyurea43 49 1211.1CSF1, CCNA2, TP53
19colchicine43 59 2 28 1213.0CLU, CCNA2, S100B, NF1
20rapamycin439.0CCNA2, ACP5, CSF1, NF1
21ethanol43 49 24 1212.0S100B, ACP5, CCNA2, CLU, DES
22adenylate438.8NF1, S100B, CSF1, CCNA2, DES
23actinomycin d438.7DES, TP53, CLU, CSF1
24fatty acid438.7DES, CLU, S100B, NF1
25lysine438.7NF1, CSF1, CCNA2, DES
26testosterone43 59 24 1211.7DES, CLU, CCNA2, ACTC1, CSF1, S100B
27lactate438.7DES, CLU, CSF1, S100B
28oxygen43 249.7DES, CLU, CCNA2, ACTC1, ACP5, S100B
29butyrate438.7TP53, CLU, CCNA2, CSF1
30dexamethasone43 49 28 1211.6CLU, CCNA2, ACTC1, ACP5, CSF1, S100B
31dopamine43 28 24 1211.6NF1, S100B, CCNA2, CLU
32heparin43 28 24 1211.5DES, CLU, ACP5, CSF1, S100B, FGF3
33proline438.5DES, TP53, CLU, CCNA2, S100B
34doxorubicin43 49 1210.5DES, TP53, CLU, CCNA2, CSF1
35etoposide43 49 59 1211.4TP53, CLU, CCNA2, CSF1, S100B
36paclitaxel43 49 1210.4TP53, CLU, CCNA2, CSF1, S100B
37cysteine438.4DES, CLU, ACP5, CSF1, S100B, NF1
38thymidine43 249.2DES, TP53, CLU, CCNA2, CSF1, S100B
39h2o2438.1DES, TP53, CLU, CCNA2, ACP5, CSF1
40arginine438.0NF1, S100B, CSF1, CCNA2, TP53, DES
41calcium43 49 24 1211.0DES, CLU, CCNA2, ACTC1, ACP5, S100B
42steroid437.9DES, CLU, CCNA2, ACTC1, S100B, NF1
43oligonucleotide437.9TP53, CLU, CCNA2, NF1, FGF3
44tyrosine437.7DES, CLU, CCNA2, ACTC1, ACP5, CSF1
45serine437.5DES, TP53, CLU, CCNA2, CSF1, S100B
46vegf437.4DES, TP53, CLU, CCNA2, ACTC1, CSF1
47progesterone43 28 59 24 1211.3DES, TP53, CLU, CCNA2, ACTC1, CSF1
48retinoic acid43 248.3DES, TP53, CLU, CCNA2, ACTC1, CSF1
49paraffin436.9NF1, DES, TP53, CLU, CCNA2, ACTC1
50estrogen436.9DES, TP53, CLU, CCNA2, ACTC1, ACP5

GO Terms for genes affiliated with Giant Cell Tumor

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Cellular components related to Giant Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5S100B, CSF1, COL6A3, ACTC1, CLU

Biological processes related to Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.8DES, ACTC1
2release of cytochrome c from mitochondriaGO:00018369.2TP53, CLU
3negative regulation of neuroblast proliferationGO:00074069.2TP53, NF1
4positive regulation of intrinsic apoptotic signaling pathwayGO:020012449.1CLU, TP53
5negative regulation of fibroblast proliferationGO:00481479.1NF1, TP53
6cell proliferationGO:00082839.0S100B, CSF1, TP53
7innate immune responseGO:00450878.9FGF3, S100B, CSF1, CLU
8Ras protein signal transductionGO:00072658.8NF1, CCNA2, TP53
9positive regulation of neuron apoptotic processGO:00435258.7NF1, TP53
10positive regulation of apoptotic processGO:00430658.4NF1, S100B, CLU, TP53

Products for genes affiliated with Giant Cell Tumor

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Sources for Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet