MCID: GNT008
MIFTS: 49

Giant Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Giant Cell Tumor

MalaCards integrated aliases for Giant Cell Tumor:

Name: Giant Cell Tumor 12 14
Giant Cell Tumors 12 51 41 69
Tumor of the Giant Cell 12
Giant Cell Tumor Nos 12
Giant Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:200
MeSH 41 D005870
NCIt 46 C3055 C7069
UMLS 69 C0017525

Summaries for Giant Cell Tumor

MalaCards based summary : Giant Cell Tumor, also known as giant cell tumors, is related to bone giant cell tumor and pigmented villonodular synovitis. An important gene associated with Giant Cell Tumor is ZNF687 (Zinc Finger Protein 687), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Xgeva and Denosumab have been mentioned in the context of this disorder. Affiliated tissues include bone, pancreas and liver, and related phenotypes are limbs/digits/tail and respiratory system

Related Diseases for Giant Cell Tumor

Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 bone giant cell tumor 33.5 CALCA CTSK VIM
2 pigmented villonodular synovitis 32.7 CSF1 MMP9 PTPRC TNFSF11
3 nodular tenosynovitis 32.7 PTPRC SERPINA3
4 villonodular synovitis 30.9 MMP9 TNFSF11 VIM
5 epulis 30.4 DES VIM
6 cystadenocarcinoma 30.2 MUC1 PTPRC VIM
7 mucinous cystadenocarcinoma 30.2 MUC1 PTPRC VIM
8 aneurysmal bone cysts 30.0 CALCA TNFRSF11A TNFSF11
9 myeloma, multiple 29.8 PTPRC TNFRSF11B TNFSF11
10 chordoma 29.7 DES MUC1 VIM
11 giant cell reparative granuloma 29.7 CALCA TNFRSF11A
12 fibrous histiocytoma 29.6 DES SERPINA3 VIM
13 dermatofibrosarcoma protuberans 29.6 DES SERPINA3 VIM
14 spindle cell sarcoma 29.5 DES MUC1 VIM
15 arthritis 29.4 CSF1 MMP9 TNFRSF11A TNFSF11
16 osteonecrosis 29.3 BGLAP TNFRSF11B TNFSF11
17 osteogenic sarcoma 29.3 BGLAP TNFRSF11B TNFSF11
18 osteitis fibrosa 29.2 BGLAP CALCA
19 fibrosarcoma 29.2 DES MMP9 VIM
20 hyperparathyroidism 29.1 BGLAP CALCA TNFRSF11B
21 cohen-gibson syndrome 29.1 BGLAP TNFRSF11A TNFRSF11B TNFSF11
22 rheumatoid arthritis 28.9 CSF1 CTSK TNFRSF11A TNFRSF11B TNFSF11
23 paget's disease of bone 28.4 BGLAP CALCA CSF1 TNFRSF11A TNFRSF11B TNFSF11
24 tenosynovial giant cell tumor 12.3
25 malignant giant cell tumor 12.2
26 malignant giant cell tumor of soft parts 12.2
27 malignant giant cell tumor of the tendon sheath 12.2
28 osteoclast-like giant cell neoplasm of the pancreas 12.1
29 osteoclastic giant cell tumor of pancreas 12.1
30 bone giant cell sarcoma 11.8
31 cherubism 11.3
32 paget disease of bone 6 11.1
33 breast leiomyosarcoma 10.5 TNFRSF11A TNFSF11
34 mandibular cancer 10.5 CSF1 TNFSF11
35 intravascular papillary endothelial hyperplasia 10.5 SERPINA3 VIM
36 retroperitoneal fibrosis 10.5 PTPRC VIM
37 kummell's disease 10.5 TNFRSF11B TNFSF11
38 periodontitis, chronic 10.4 TNFRSF11B TNFSF11
39 gingival hypertrophy 10.4 MMP9 VIM
40 chronic apical periodontitis 10.4 TNFRSF11B TNFSF11
41 skin glomus tumor 10.4 DES VIM
42 malignant peritoneal mesothelioma 10.4 MUC1 VIM
43 infantile digital fibromatosis 10.4 DES VIM
44 papillary tumor of the pineal region 10.4 MUC1 VIM
45 lymphangiomatosis 10.4 DES VIM
46 angiolipoma 10.4 DES VIM
47 cutaneous leiomyosarcoma 10.4 DES VIM
48 fibrous meningioma 10.4 MUC1 VIM
49 periostitis 10.4 TNFRSF11A TNFRSF11B
50 chordoid meningioma 10.4 MUC1 VIM

Graphical network of the top 20 diseases related to Giant Cell Tumor:



Diseases related to Giant Cell Tumor

Symptoms & Phenotypes for Giant Cell Tumor

MGI Mouse Phenotypes related to Giant Cell Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.43 CSF1 CTSK MMP9 TNFRSF11A TNFRSF11B TNFSF11
2 respiratory system MP:0005388 9.17 CSF1 CTSK MMP9 PTPRC TNFRSF11A TNFSF11

Drugs & Therapeutics for Giant Cell Tumor

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Xgeva 17 45 DENOSUMAB Amgen June 2013/ November 2010

Drugs for Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 1406-16-2
3 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1
4 Calcium, Dietary Phase 4,Phase 2
5 Vitamins Phase 4,Phase 2,Phase 1
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
7
Ethanol Approved Phase 3 64-17-5 702
8
Phenol Approved, Experimental Phase 3 108-95-2 996
9
Zoledronic acid Approved Phase 3,Phase 1,Phase 2 118072-93-8 68740
10 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
11 Liver Extracts Phase 3
12 Adjuvants, Anesthesia Phase 3,Phase 1
13 Analgesics Phase 3
14 Analgesics, Opioid Phase 3
15 Anesthetics Phase 3,Phase 1
16 Anesthetics, General Phase 3,Phase 1
17 Anesthetics, Intravenous Phase 3,Phase 1
18 Central Nervous System Depressants Phase 3,Phase 1
19 Narcotics Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Antibodies Phase 3,Phase 1,Phase 2
22 Antibodies, Monoclonal Phase 3,Phase 2
23 Immunoglobulins Phase 3,Phase 1,Phase 2
24 Diphosphonates Phase 3,Phase 2
25 Polymethyl Methacrylate Phase 3
26 Cola Nutraceutical Phase 3
27
nivolumab Approved Phase 2 946414-94-4
28
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
29 Micronutrients Phase 2,Phase 1
30 Trace Elements Phase 2,Phase 1
31 Protein Kinase Inhibitors Phase 2
32 Pharmaceutical Solutions Phase 1, Phase 2
33 Grapefruit Seed Extract Nutraceutical Phase 2
34
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
35
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
36
Warfarin Approved Phase 1 81-81-2 54678486 6691
37
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
38
Phytonadione Approved, Investigational, Nutraceutical Phase 1 84-80-0 5284607 4812
39 Albumin-Bound Paclitaxel Phase 1
40 Antimitotic Agents Phase 1
41 Antineoplastic Agents, Phytogenic Phase 1
42 Anti-Anxiety Agents Phase 1
43 Anticoagulants Phase 1
44 Antifibrinolytic Agents Phase 1
45 Coagulants Phase 1
46 GABA Agents Phase 1
47 GABA Modulators Phase 1
48 Hemostatics Phase 1
49 Hypnotics and Sedatives Phase 1
50 Neurotransmitter Agents Phase 1

Interventional clinical trials:

(show all 24)

# Name Status NCT ID Phase Drugs
1 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 Recruiting NCT03301857 Phase 4 Cohort A Denosumab
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone Recruiting NCT03259152 Phase 3 Denosumab
4 Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone Recruiting NCT03295981 Phase 3 Zoledronic Acid
5 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 PLX3397;Placebo
6 Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone Completed NCT00396279 Phase 2
7 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
8 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
9 Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2 FPA008
10 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
11 Study of Denosumab in Subjects With Giant Cell Tumor of Bone Active, not recruiting NCT00680992 Phase 2 Denosumab
12 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
13 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo
14 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2 Dasatinib
15 Study of the Effect of Zoledronate on Local Recurrence After Surgical Treatment of Giant Cell Tumors of Bone Zométa Terminated NCT01564121 Phase 1, Phase 2 acid Zoledronic
16 Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT) Terminated NCT00889590 Phase 2 Zoledronic acid
17 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Active, not recruiting NCT02673736 Phase 1 PLX73086
18 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Active, not recruiting NCT01804530 Phase 1 PLX7486 TsOH
19 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Active, not recruiting NCT01494688 Phase 1 Paclitaxel;RO5509554
20 Pexidartinib Effects on How the Body Processes Midazolam and S-warfarin (Pharmacokinetics) Not yet recruiting NCT03291288 Phase 1 S-warfarin;Midazolam;Pexidartinib
21 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733 cyclophosphamide
22 Giant Cell Tumor of the Extremities Treated With Surgery and/or Medical Treatment Completed NCT02996734
23 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088
24 Safety and Efficacy of Post-operative Denosumab Strategy for Giant Cell Tumor of Bone Treatment in China Not yet recruiting NCT03358212 Denosumab

Search NIH Clinical Center for Giant Cell Tumor

Cochrane evidence based reviews: giant cell tumors

Genetic Tests for Giant Cell Tumor

Anatomical Context for Giant Cell Tumor

MalaCards organs/tissues related to Giant Cell Tumor:

38
Bone, Pancreas, Liver, Salivary Gland, Uterus, Skin, Lung

Publications for Giant Cell Tumor

Articles related to Giant Cell Tumor:

(show top 50) (show all 900)
# Title Authors Year
1
Recurrence of Giant Cell Tumor of The Larynx. ( 29419584 )
2018
2
Resection of a Giant-Cell Tumor of the Proximal Aspect of the Radius with Osteoarticular Allograft Reconstruction: A Case Report. ( 29443818 )
2018
3
Pycnodysostosis: Novel Variants in<i>CTSK</i>and Occurrence of Giant Cell Tumor. ( 29441215 )
2018
4
Mid- to long-term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization. ( 29315595 )
2018
5
Retrospective Analysis of Giant Cell Tumor Lower End Radius Treated with<i>En bloc</i>Excision and Translocation of Ulna. ( 29416164 )
2018
6
Osteonecrosis of the Jaw and Rebound Hypercalcemia in Young People Treated With Denosumab for Giant Cell Tumor of Bone. ( 29211870 )
2018
7
Retrospective investigation of "paint brush borders" sign in association with local recurrence of giant cell tumor of bone after intralesional curettage. ( 29255669 )
2018
8
Extra-articular tenosynovial giant cell tumor of diffuse type in the temporal area with brain parenchymal invasion: a case report. ( 29334779 )
2018
9
Denosumab-Treated Giant Cell Tumor of the Bone Mimicking Low-Grade Central Osteosarcoma. ( 29429326 )
2018
10
The Values of Receptor Activator Nuclear Kappa-B Ligand Expression in Stage III Giant Cell Tumor of the Bone. ( 29416167 )
2018
11
Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR). ( 29254795 )
2018
12
Uncemented three-dimensional-printed prosthetic replacement for giant cell tumor of distal radius: a new design of prosthesis and surgical techniques. ( 29445303 )
2018
13
Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images. ( 29429890 )
2018
14
Giant Cell Tumor of Bone in Patients 55 Years and Older: A Study of 34 Patients. ( 29425276 )
2018
15
Giant cell tumor mimicking melanoma metastasis: radioguided surgery of a lesion detected on PET/CT. ( 28613000 )
2017
16
Combining of serial embolization and denosumab for large sacropelvic giant cell tumor: Case report of 3 cases. ( 28816971 )
2017
17
Primary giant cell tumor of the female breast: a diagnostic red herring with therapeutic implications. ( 27862328 )
2017
18
Postpartum Treatment of Metastatic Recurrent Giant Cell Tumor of Capitate Bone of Wrist. ( 28856360 )
2017
19
TRAIL-R1 as a novel surface marker for circulating giant cell tumor of bone. ( 28881598 )
2017
20
Osseous Myopericytoma Simulating a Giant Cell Tumor of Bone: A Case Report. ( 29244665 )
2017
21
Extra-articular diffuse-type tenosynovial giant cell tumor with benign histological features resulting in fatal pulmonary metastases. ( 28219303 )
2017
22
TGF-I^2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone. ( 28903395 )
2017
23
Giant cell tumor of bone revisited. ( 28905737 )
2017
24
Giant Cell Tumor of the Ribs and Aneurysmal Bone Cyst Presenting With Hemothorax in a Child. ( 28859035 )
2017
25
Giant cell tumor locally advanced around the knee: treatment and literature review. ( 28884107 )
2017
26
Development and validation of a prognostic index to predict pulmonary metastasis of giant cell tumor of bone. ( 29296223 )
2017
27
Rare Giant Cell Tumor of the Distal Flexor Digitorum Longus Tendon Sheath and Early Diagnosis with Use of Magnetic Resonance Imaging. ( 28880600 )
2017
28
Diagnosing giant cell tumor of the bone using positron emission tomography/computed tomography: A retrospective study of 20 patients from a single center. ( 28781642 )
2017
29
Tenosynovial Giant Cell Tumor in the Midfoot Treated With Femoral Head Allograft Reconstruction. ( 28864387 )
2017
30
Giant cell tumor of soft tissue is genetically distinct from its bone counterpart. ( 28084336 )
2017
31
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
32
A Case of a Giant Cell Tumor of the Tendon Sheath of the Middle Phalanx of the Fourth Toe. ( 29279564 )
2017
33
Giant cell tumor of the frontal sinus: a typical finding in an unlikely location. ( 29307940 )
2017
34
Recurrent primary mediastinal giant cell tumor of soft tissue with radiological findings: a rare case report and literature review. ( 28747182 )
2017
35
Giant Cell Tumor of Bone and Other Giant Cell-Rich Lesions. ( 28750392 )
2017
36
Pitfalls in the cytological diagnosis of tenosynovial giant cell tumor: An illustration of eight discordant cases. ( 28941190 )
2017
37
Histone 3.3 Mutations in Giant Cell Tumor and Giant Cell-Rich Sarcomas of Bone. ( 28899740 )
2017
38
MiR-127 and miR-376a act as tumor suppressors by inA vivo targeting of COA1 and PDIA6 in giant cell tumor of bone. ( 28866093 )
2017
39
H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone. ( 28505000 )
2017
40
Multicentric giant cell tumor of bone: Case series of 4 patients. ( 28869118 )
2017
41
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
42
Transformation of Benign Giant Cell Tumor of Bone Into Epithelioid Angiosarcoma. ( 29309463 )
2017
43
Prognosis of Advanced Tenosynovial Giant Cell Tumor of the Knee Diagnosed During Total Knee Arthroplasty. ( 28161138 )
2017
44
Giant Cell Tumor of the Sacrum: Series of 19 Patients and Review of the Literature. ( 29299501 )
2017
45
Fine needle aspiration cytology diagnosis of metastatic malignant diffuse type tenosynovial giant cell tumor. ( 28701836 )
2017
46
Tenosynovial Giant Cell Tumor: Incidence, Prevalence, Patient Characteristics, and Recurrence. A Registry-based Cohort Study in Denmark. ( 28765257 )
2017
47
Imaging features for diffuse-type tenosynovial giant cell tumor of the temporomandibular joint: A case report. ( 28658169 )
2017
48
Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor. ( 28943907 )
2017
49
Microsurgical reconstruction in limb salvage due to a giant cell tumor of the distal radius. Case report. ( 28840677 )
2017
50
Giant-cell Tumor of Metacarpal in the Skeletally Immature Patient and Free Osteoarticular Metatarsal Transfer: Review of Literature with Case Report. ( 29242789 )
2017

Variations for Giant Cell Tumor

Expression for Giant Cell Tumor

Search GEO for disease gene expression data for Giant Cell Tumor.

Pathways for Giant Cell Tumor

Pathways related to Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CSF1 CTSK MMP9 MUC1 PTPRC SERPINA3
2
Show member pathways
13.06 CSF1 MMP9 MUC1 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.07 CTSK TNFRSF11A TNFRSF11B TNFSF11
4 11.74 MMP9 MUC1 VIM
5 11.66 CSF1 CTSK TNFRSF11A TNFRSF11B TNFSF11
6
Show member pathways
11.65 ADAM12 CTSK MMP9
7 11.62 BGLAP DES PTPRC
8 11.58 CSF1 CTSK TNFRSF11A TNFSF11
9
Show member pathways
11.52 TNFRSF11A TNFRSF11B TNFSF11
10 10.67 BGLAP CALCA TNFRSF11A TNFRSF11B TNFSF11
11 10.58 BGLAP TNFRSF11B TNFSF11
12 10.46 CTSK TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Giant Cell Tumor

Cellular components related to Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ADAM12 BGLAP CALCA CSF1 CTSK H3F3A
2 extracellular space GO:0005615 9.32 ADAM12 BGLAP CALCA CSF1 CTSK MMP9

Biological processes related to Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.83 CALCA CSF1 SERPINA3 TNFRSF11A TNFRSF11B
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.73 TNFRSF11A TNFRSF11B TNFSF11
3 bone resorption GO:0045453 9.58 CTSK TNFSF11
4 positive regulation of osteoclast differentiation GO:0045672 9.57 CSF1 TNFSF11
5 mammary gland alveolus development GO:0060749 9.55 TNFRSF11A TNFSF11
6 macrophage differentiation GO:0030225 9.54 CSF1 MMP9
7 monocyte chemotaxis GO:0002548 9.54 CALCA TNFRSF11A TNFSF11
8 intermediate filament organization GO:0045109 9.52 DES VIM
9 regulation of osteoclast differentiation GO:0045670 9.51 BGLAP TNFSF11
10 response to inorganic substance GO:0010035 9.49 BGLAP TNFRSF11B
11 positive regulation of macrophage differentiation GO:0045651 9.48 CALCA CSF1
12 negative regulation of bone resorption GO:0045779 9.46 CALCA TNFRSF11B
13 TNFSF11-mediated signaling pathway GO:0071847 9.4 TNFRSF11A TNFSF11
14 osteoclast proliferation GO:0002158 9.32 CSF1 TNFSF11
15 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.26 TNFRSF11A TNFSF11
16 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFRSF11A TNFSF11
17 osteoclast differentiation GO:0030316 9.13 CSF1 TNFRSF11A TNFSF11
18 ossification GO:0001503 8.92 BGLAP MMP9 TNFRSF11A TNFSF11

Molecular functions related to Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 CALCA CSF1 CTSK DES H3F3A MMP9

Sources for Giant Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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