MCID: GNT008
MIFTS: 60

Giant Cell Tumor malady

Cancer diseases category

Summaries for Giant Cell Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Giant-cell tumor of the bone (GCTOB) is a relatively uncommon tumor of the bone. It is characterized by... more...

MalaCards: Giant Cell Tumor, also known as giant cell tumors, is related to pigmented villonodular synovitis and synovitis. An important gene associated with Giant Cell Tumor is DES (desmin), and among its related pathways are Osteoclast differentiation and BAFF in B-Cell Signaling. The compounds calcium and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and lung, and related mouse phenotypes are homeostasis/metabolism and skeleton.

Aliases & Classifications for Giant Cell Tumor

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

giant cell tumor 8 10
giant cell tumors 8 44 60
tumor of the giant cell 8
carcinoma giant cell 44
giant cell tumor nos 8
giant cell neoplasm 8


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Disease Ontology8 DOID:200
MeSH34 D005870
NCIt39 C7069, C3055

Related Diseases for Giant Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.0CSF1
2synovitis31.0TNFSF11, TNFRSF11B
3paget's disease of bone30.7TNFRSF11A, CALCA
4cystadenocarcinoma30.6CEACAM3
5osteosarcoma30.5ACP5, PLAUR, CTSK, TNFRSF11B, TNFSF11, TNFRSF11A
6sarcoma30.5CCNA2, CALB2, S100B, CSF1, DES, MYOG
7adenocarcinoma30.4CCNA2, CA2, CALB2, TNFSF11, PLAUR, ACTC1
8chondrosarcoma30.4CEACAM3, SERPINA3, DES, CTSK, S100B
9hyperparathyroidism30.4CALCA, TNFSF11, TNFRSF11B, FGF23, ACP5
10cherubism30.4CALCA, TNFSF11
11giant cell reparative granuloma30.3CALCA, TNFRSF11A
12leiomyosarcoma30.2CALB2, S100B, DES, MYOG, ACTC1
13bone carcinoma30.2CEACAM3, TNFRSF11B, TNFSF11, TNFRSF11A, CSF1
14bladder carcinoma30.2CCNA2, CSF1, PLAUR
15thyroiditis30.2CALCA
16pancreatitis30.2CA2
17primary hyperparathyroidism30.2CALCA, FGF23, ACP5
18squamous cell carcinoma30.2CCNA2, CALB2, PLAUR, ACTC1, SERPINA3, CEACAM3
19hemangioma30.2ACTC1
20melanoma30.0CEACAM3, SERPINA3, PTPRC, ACTC1, PLAUR, DES
21osteoarthritis30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK
22arthritis30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK
23rheumatoid arthritis30.0CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK, ACP5
24myeloma30.0CCNA2, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK
25hypercalcemia30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, FGF23
26fibrous histiocytoma30.0S100B, DES, ACTC1, SERPINA3
27adenoma30.0CCNA2, CALCA, CALB2, ACTC1, CEACAM3
28microphthalmia30.0S100B, TNFSF11, ACTC1, ACP5
29spindle cell sarcoma30.0S100B, DES, ACTC1
30chordoma30.0CEACAM3, DES, S100B
31multiple myeloma30.0TNFRSF11B, TNFSF11
32osteomyelitis30.0TNFSF11, CTSK, ACP5
33hepatocellular carcinoma30.0CCNA2, TNFSF11, PLAUR, ACP5, CEACAM3
34pleomorphic adenoma30.0S100B, DES, ACTC1
35neuropathy30.0MYOG, CALCA
36osteomalacia30.0FGF23, TNFRSF11B, CALCA
37spindle cell carcinoma30.0ACTC1, DES
38thyroid cancer30.0PLAUR, TNFRSF11B, CALCA
39fibrosarcoma30.0DES, PLAUR, ACTC1
40bone giant cell tumor11.2
41malignant giant cell tumor11.0
42tenosynovial giant cell tumor10.9
43villonodular synovitis10.7
44malignant giant cell tumor of soft parts10.6
45malignant giant cell tumor of the tendon sheath10.4
46bone giant cell sarcoma10.4
47tuberous sclerosis10.4
48cervicitis10.4
49nodular tenosynovitis10.4
50mucinous cystadenocarcinoma10.4

Graphical network of the top 20 diseases related to Giant Cell Tumor:



Diseases related to giant cell tumor

Clinical Features for Giant Cell Tumor

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Drugs & Therapeutics for Giant Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Giant Cell Tumor

Search CenterWatch for Giant Cell Tumor

Genetic Tests for Giant Cell Tumor

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Anatomical Context for Giant Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Giant Cell Tumor:

32
Bone, Monocytes, Lung, Pancreas, Breast, Skin, Salivary gland, Uterus, Lymph node, Liver, Thyroid, T cells, Ovary, Tongue, Kidney, Spinal cord, Prostate, Smooth muscle, Pancreatic islet, Bone marrow

Animal Models for Giant Cell Tumor or affiliated genes

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36MGI
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Publications for Giant Cell Tumor

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50PubMed
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Articles related to Giant Cell Tumor:

(show top 50)    (show all 758)
idTitleAuthorsYear
1
Transarterial embolization (TAE) of sacral giant cell Tumor (GCT) using spherical parmanent embolic material superabsorbant polymer microsphere (SAP-MS). (24353982)
2013
2
Subchondral bone grafting reduces degenerative change of knee joint in patients of giant cell tumor of bone. (23981611)
2013
3
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. (24162739)
2013
4
Multicentric giant cell tumor in adolescents: three case reports. (22643128)
2013
5
Giant cell tumor of bone in a child with Goltz syndrome. (23530933)
2013
6
Meticulous surgical excision of a localized giant cell tumor of the tendon sheath. (23573342)
2013
7
Giant cell tumor of the distal ulna: a case report. (22657940)
2012
8
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
9
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). (22867750)
2012
10
Giant cell tumor of bone: are we stratifying results appropriately? (22125240)
2012
11
Stro-1(+) stromal cells have stem-like features in giant cell tumor of bone. (22605660)
2012
12
Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institution. (22398741)
2012
13
Giant cell tumor of the tendon sheath: experience with 65 cases. (23185646)
2012
14
Giant cell tumor of the pes anserine bursa (extra-articular pigmented villonodular bursitis): a case report and review of the literature. (21687595)
2011
15
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
16
Unifocal giant cell tumor of the triquetrum: a case report. (21930623)
2011
17
Local recurrences after curettage and cementing in long bone giant cell tumor. (21430873)
2011
18
Multiple giant cell tumors in maxilla and skull complicating Paget's disease of bone. (21319038)
2010
19
Giant cell tumor of the femoral head and neck: result of intralesional curettage. (20020148)
2010
20
Giant cell tumor of the extremity: A review of 349 cases from a single institution. (19879054)
2010
21
Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatment. (20675862)
2010
22
Synchronous multicentric giant cell tumor. (20479561)
2010
23
Case report: reconstruction of the distal tibia with porous tantalum spacer after resection for giant cell tumor. (19756900)
2010
24
Resection-reconstruction arthroplasty for giant cell tumor of distal radius. (20697488)
2010
25
Giant cell tumor in a case of Paget's disease of bone: an aggressive benign tumor exhibiting a quick response to an innovative therapeutic agent. (22460021)
2010
26
Botulinum toxin: a novel adjuvant for giant cell tumor. (18165877)
2008
27
Aggressive giant cell tumor at proximal femur after total hip arthroplasty. (19080186)
2008
28
Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy. (18451399)
2008
29
Giant cell tumor of fifth lumbar vertebrae: two case reports and review of the literature. (17630149)
2007
30
Osteoclastomalike giant cell tumor of the parotid gland: report of a case with fine needle aspiration diagnosis. (16514845)
2006
31
Unusual aggressive course of a giant cell tumor of soft tissue during immunosuppressive therapy. (16596381)
2006
32
Recurrence potential of diffuse-type giant cell tumor in the foot: radiologic and pathologic features. (15960914)
2005
33
An endometrial stromal tumor with osteoclast-like giant cells. (15944960)
2005
34
Triple total cervical vertebrectomy for a giant cell tumor: case report. (15897818)
2005
35
Tenosynovial giant cell tumor]. (15657685)
2005
36
Subependymal giant cell tumors in tuberous sclerosis complex. (15505165)
2004
37
Giant cell formation through fusion of cells derived from a human giant cell tumor of tendon sheath. (16228675)
2004
38
Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesis. (12865629)
2002-2003
39
Primary mediastinal giant cell tumors: a clinicopathologic and immunohistochemical study of two cases. (12004357)
2002
40
Expression and significance of urokinase-type plasminogen activator, its receptor, and type 2 inhibitor in giant cell tumor of bone]. (11810768)
2001
41
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. (11220389)
2001
42
An osteoclast-like giant cell tumor pattern in a mucinous cystadenocarcinoma of the pancreas with lymph node metastasis in a patient surviving over 10 years. (11407484)
2001
43
Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone. (10547161)
1999
44
Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone. (9219728)
1997
45
Histochemical and immunohistochemical characterization of cells constituting the giant cell tumor of bone. (8448954)
1993
46
Metastatic amelanotic melanoma simulating giant-cell tumor of bone. (2394440)
1990
47
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. (314048)
1979
48
Giant islet cell tumor of the pancreas with alpha-like granules. An ultrastructural study. (4356728)
1973
49
A clinicopathologic study of alveolar border epulis with special emphasis on benign giant-cell tumor. (13349105)
1956
50
Peripheral giant-cell tumor (giant-cell epulis); report of case. (20992472)
1946

Genetic Variations for Giant Cell Tumor

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Expression for genes affiliated with Giant Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Giant Cell Tumor

Search GEO for disease gene expression data for Giant Cell Tumor.

Pathways for genes affiliated with Giant Cell Tumor

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Giant Cell Tumor

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Giant Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.2TNFRSF11A, DES, CTSK, TNFRSF11B, TNFSF11, S100B
2tyrosine4411.2CEACAM3, PTPRC, ACP5, ACTC1, PLAUR, TNFRSF11A
3oxygen44 2412.1TNFRSF11A, S100B, CEACAM3, CA2, CCNA2, ACP5
4paraffin4411.1PLAUR, MYOG, DES, TNFSF11, CSF1, S100B
5vegf4411.1TNFSF11, CSF1, S100B, CALCA, CCNA2, ACTC1
6steroid4411.1MYOG, TNFSF11, S100B, CALB2, CA2, CCNA2
7nitric oxide44 11 2413.1TNFRSF11B, TNFSF11, DES, MYOG, TNFRSF11A, CEACAM3
8creatinine4411.1CEACAM3, SERPINA3, ACTC1, PLAUR, FGF23, TNFRSF11B
9testosterone44 59 11 2414.1S100B, CCNA2, ACTC1, CALCA, CALB2, CSF1
10serine4411.1FGF23, MYOG, SERPINA3, CTSK, TNFRSF11B, TNFRSF11A
11cysteine4411.1CA2, S100B, DES, CSF1, MYOG, ACP5
12heparin44 28 11 2414.1PTPRC, FGF23, DES, TNFRSF11B, TNFSF11, CSF1
13calcitriol44 59 11 2414.0TNFSF11, CALCA, CA2, CSF1, TNFRSF11B, FGF23
14retinoic acid44 2412.0PLAUR, TNFRSF11B, CTSK, MYOG, DES, CA2
15progesterone44 59 28 11 2415.0PTPRC, CSF1, CCNA2, CALB2, TNFRSF11B, DES
16hydroxyapatite4411.0FGF23, CTSK, TNFRSF11B, TNFSF11, TNFRSF11A, S100B
17lipid4411.0CA2, S100B, TNFRSF11A, TNFSF11, TNFRSF11B, SERPINA3
18dexamethasone44 49 28 1114.0S100B, ACP5, TNFSF11, PTPRC, TNFRSF11B, PLAUR
191,25 dihydroxy vitamin d34411.0CALCA, TNFRSF11A, ACP5, FGF23, TNFRSF11B, TNFSF11
20b 7234411.0CALB2, ACTC1, DES, S100B, PTPRC, CEACAM3
21tartrate4411.0ACP5, TNFSF11, CSF1, CALCA, CTSK
22estrogen4411.0CA2, CALB2, MYOG
23cyclosporin a44 28 5912.9PTPRC, ACP5, TNFRSF11B, ACTC1, TNFSF11, S100B
24mucicarmine4410.9DES, S100B, ACTC1, CEACAM3, CALB2
25hematoxylin4410.9CEACAM3, DES, PTPRC, S100B, ACTC1, CALB2
26denosumab44 1111.9TNFSF11, TNFRSF11A, CALCA, TNFRSF11B
27hydrogen44 2411.9TNFSF11, S100B, CEACAM3, ACP5, PTPRC, CTSK
28teriparatide44 1111.9CTSK, TNFRSF11B, CALCA, TNFSF11
29polyethylene4410.9TNFSF11, TNFRSF11B, TNFRSF11A, CTSK
3025-hydroxyvitamin d4410.9TNFRSF11B, CALCA, TNFSF11, FGF23, ACP5
31phosphorus4410.9TNFSF11, FGF23, ACP5, CALCA, TNFRSF11B
32vitamin k24410.9TNFRSF11B, TNFSF11, CSF1, CALCA
33aspartate4410.9CA2, CTSK, ACP5, CEACAM3, CCNA2
34celecoxib44 59 28 49 11 2415.8TNFRSF11B, TNFSF11, CSF1, CA2, CCNA2
35clodronate44 49 1112.8CALCA, TNFSF11, TNFRSF11B, ACP5
36acetylcholine44 49 28 11 2414.8CALB2, MYOG, SERPINA3, CALCA
37forskolin44 49 1112.8CCNA2, PLAUR, MYOG, TNFRSF11B, TNFSF11, S100B
38pmma4410.8CALCA, TNFSF11, TNFRSF11B, ACP5
39iron44 2411.8SERPINA3, S100B, ACTC1, PLAUR, ACP5, DES
40procollagen4410.8ACP5, TNFSF11
41glucose4410.8MYOG, PLAUR, ACTC1, SERPINA3, CEACAM3
42gp 1304410.8TNFSF11, TNFRSF11B, PLAUR, CSF1, TNFRSF11A
43zoledronic acid4410.7TNFRSF11B, CALCA, TNFSF11, CTSK
44deoxypyridinoline4410.7CALCA, TNFSF11, ACP5, TNFRSF11B
45strontium ranelate4410.6CTSK, CALCA, TNFSF11
46arginine4410.6SERPINA3, CSF1, DES, FGF23, PLAUR, S100B
47superoxide44 2411.6PTPRC, SERPINA3
48alendronate44 49 1112.5ATP6V1A, TNFRSF11B, CALCA, TNFSF11
49thymidine44 2411.5CEACAM3, PLAUR, DES, CSF1, S100B, CALB2
50orcein4410.2DES, ACTC1, S100B

GO Terms for genes affiliated with Giant Cell Tumor

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16Gene Ontology
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Cellular components related to Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6S100B, TNFSF11, TNFRSF11B, CTSK, FGF23, PLAUR
2extracellular spaceGO:00561510.3SERPINA3, CALCA, CA2, S100B, CSF1, TNFSF11

Biological processes related to Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1ossificationGO:00150310.8MYOG, TNFSF11, TNFRSF11A, CSF1
2positive regulation of osteoclast differentiationGO:04567210.8CA2, CSF1, TNFSF11
3monocyte chemotaxisGO:00254810.8CALCA, TNFRSF11A, TNFSF11
4bone resorptionGO:04545310.7ACP5, CTSK, TNFSF11
5osteoclast differentiationGO:03031610.7CSF1, TNFRSF11A, TNFSF11
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.7TNFSF11, TNFRSF11A
7TNFSF11-mediated signaling pathwayGO:07184710.7TNFSF11, TNFRSF11A
8positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.6TNFSF11, TNFRSF11A
9osteoclast proliferationGO:00215810.6TNFSF11
10mammary gland alveolus developmentGO:06074910.5TNFSF11, TNFRSF11A
11negative regulation of bone resorptionGO:04577910.5CALCA, TNFRSF11B
12positive regulation of macrophage differentiationGO:04565110.4CSF1, CALCA
13positive regulation of bone resorptionGO:04578010.2TNFSF11, CA2

Products for genes affiliated with Giant Cell Tumor

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Sources for Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet