MCID: GNT008
MIFTS: 58

Giant Cell Tumor malady

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Summaries for Giant Cell Tumor

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Wikipedia:65 Giant-cell tumor of the bone (GCTOB) is a relatively uncommon tumor of the bone. It is characterized by... more...

MalaCards based summary: Giant Cell Tumor, also known as giant cell tumors, is related to pigmented villonodular synovitis and fibroma. An important gene associated with Giant Cell Tumor is DES (desmin), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and GADD45 Pathway. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and lung, and related mouse phenotypes are limbs/digits/tail and cardiovascular system.

Aliases & Classifications for Giant Cell Tumor

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
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Giant Cell Tumor, Aliases & Descriptions:

Name: Giant Cell Tumor 8 10
Giant Cell Tumors 8 44 62
Tumor of the Giant Cell 8 62
 
Giant Cell Neoplasm 8 62
Giant Cell Tumor Nos 8
Carcinoma Giant Cell 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:200
MeSH34 D005870
NCIt39 C3055, C7069

Related Diseases for Giant Cell Tumor

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Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.9CSF1
2fibroma31.0DES, ACTC1
3chordoma30.6S100B, DES
4spindle cell sarcoma30.5ACTC1, DES, S100B
5dermatofibrosarcoma protuberans30.5DES, S100B, ACTC1
6fibrous histiocytoma30.5DES, S100B, ACTC1
7pleomorphic adenoma30.5S100B, ACTC1, DES
8microphthalmia30.5S100B, ACTC1, ACP5
9hemangioma30.4ACTC1, NF1, CLU
10hyperparathyroidism30.4ACP5, NF1, FGF3
11osteosarcoma30.3CCNA2, CSF1, ACP5, TP53
12fibrosarcoma30.3ACTC1, CLU, DES
13leiomyosarcoma30.2DES, TP53, ACTC1, S100B
14myeloma30.2CSF1, CCNA2, ACP5
15osteoarthritis30.0CSF1, CLU, ACP5
16adenocarcinoma29.9CLU, CCNA2, TP53, ACTC1
17arthritis29.9ACP5, CLU, CSF1
18adenoma29.7ACTC1, FGF3, CCNA2, TP53
19sarcoma29.3CLU, DES, TP53, CCNA2, ACTC1, CSF1
20melanoma28.7FGF3, DES, TP53, CCNA2, ACTC1, CSF1
21malignant giant cell tumor11.0
22tenosynovial giant cell tumor10.9
23synovitis10.7
24villonodular synovitis10.7
25bone giant cell tumor10.7
26malignant giant cell tumor of soft parts10.6
27infantile myofibromatosis10.5DES
28histiocytosis10.5S100B
29paget's disease of bone10.5
30fasciitis10.5ACTC1
31fibrous meningioma10.5S100B
32gemistocytic astrocytoma10.5S100B
33syringoma10.5S100B
34aneurysmal bone cysts10.5
35malignant giant cell tumor of the tendon sheath10.5
36aneurysm10.5
37nodular tenosynovitis10.5
38tuberous sclerosis10.5
39cervicitis10.5
40ganglioglioma10.5S100B
41cystadenocarcinoma10.4
42osteoclast-like giant cell neoplasm of the pancreas10.4
43epithelioid leiomyosarcoma10.4DES, ACTC1
44pseudosarcomatous fibromatosis10.4ACTC1, DES
45spindle cell carcinoma10.4ACTC1, DES
46mucinous cystadenocarcinoma10.4
47epulis10.4
48tuberous sclerosis complex10.4
49desmoid tumor10.4ACTC1, DES
50adenosarcoma10.4ACTC1, DES

Graphical network of the top 20 diseases related to Giant Cell Tumor:



Diseases related to giant cell tumor

Symptoms for Giant Cell Tumor

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Drugs & Therapeutics for Giant Cell Tumor

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Drug clinical trials:

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Genetic Tests for Giant Cell Tumor

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Anatomical Context for Giant Cell Tumor

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MalaCards organs/tissues related to Giant Cell Tumor:

32
Bone, Monocytes, Lung, Pancreas, Salivary gland, Breast, Skin, Uterus, Lymph node, Spinal cord, Kidney, Liver, Thyroid, Ovary, Prostate, T cells, Tongue, Bone marrow

Animal Models for Giant Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Giant Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.9TP53, ACP5, CSF1, NF1, FGF3
2MP:00053857.7DES, TP53, CLU, ACTC1, CSF1, NF1
3MP:00053867.6DES, TP53, CSF1, S100B, NF1, FGF3
4MP:00028737.6TP53, ACTC1, S100B, NF1, FGF3
5MP:00053907.5TP53, ACP5, COL6A3, CSF1, NF1, FGF3
6MP:00053787.4FGF3, NF1, CSF1, COL6A3, ACTC1, TP53
7MP:00053697.3NF1, DES, TP53, CLU, ACTC1, COL6A3
8MP:00053877.3TP53, CLU, CCNA2, ACP5, CSF1, NF1
9MP:00107687.1DES, TP53, CCNA2, ACTC1, CSF1, NF1

Publications for Giant Cell Tumor

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Articles related to Giant Cell Tumor:

(show top 50)    (show all 704)
idTitleAuthorsYear
1
Giant cell tumor of bone. (25378541)
2014
2
Computer assisted histomorphologic comparision and the expression of AgNORs in the central and peripheral giant cell lesions of the oral cavity and giant cell tumor of the long bone. (25364180)
2014
3
MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13. (24360951)
2013
4
A misdiagnosis led to an extensive skull base surgery: infratemporal tuberculosis mimicking giant cell tumor. (24381928)
2013
5
Transarterial embolization (TAE) of sacral giant cell Tumor (GCT) using spherical parmanent embolic material superabsorbant polymer microsphere (SAP-MS). (24353982)
2013
6
Endoscopic endonasal approach for the treatment of a large clival giant cell tumor complicated by an intraoperative internal carotid artery rupture. (23403482)
2013
7
Salivary gland pleomorphic adenoma with giant cell tumor component. (23349467)
2013
8
Giant cell tumor of the distal ulna: a case report. (22657940)
2012
9
Intra-articular tenosynovial giant cell tumor arising from the posterior cruciate ligament. (22784912)
2012
10
RANKL, denosumab, and giant cell tumor of bone. (22581354)
2012
11
Oncogenic osteomalacia from nasal cavity giant cell tumor. (22311466)
2012
12
Intralesional excision versus wide resection for giant cell tumor involving the acetabulum: which is better? (22125245)
2012
13
Giant cell tumor of tendon sheath mimicking pyogenic granuloma in the index finger pulp: a case report. (22351549)
2012
14
Custom made tumor-prosthesis as a primary treatment for giant cell tumor of femur--case report. (21393650)
2011
15
Distal radioulnar joint prosthesis for the treatment of giant cell tumor of the distal ulna: a case report and literature review. (21773775)
2011
16
The management of subependymal giant cell tumors in tuberous sclerosis: a clinician's perspective. (21305305)
2011
17
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. (21924561)
2011
18
Giant cell tumor of the pes anserine bursa (extra-articular pigmented villonodular bursitis): a case report and review of the literature. (21687595)
2011
19
Tenosynovial giant cell tumor of the thigh: positron emission tomography findings. (21869945)
2011
20
Giant-cell tumor of the fourth metacarpal bone in children: case report. (19898253)
2010
21
Multiple giant cell tumors in maxilla and skull complicating Paget's disease of bone. (21319038)
2010
22
Giant cell tumor of the thoracic spine: case report and review of the literature. (18207522)
2009
23
Infiltrating giant cell tumor in a case of Paget's disease of bone. (20234860)
2009
24
Wide resection and stabilization of ulnar stump by extensor carpi ulnaris for giant cell tumor of distal ulna: two case reports. (19830093)
2009
25
Giant cell tumor of the EDL tendon sheath: an unusual cause of hallux valgus. (18510911)
2008
26
Primary giant cell tumor of soft tissue in the finger. (18713588)
2008
27
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
28
Giant cell tumor of the rib. (16883463)
2006
29
RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone. (16939392)
2006
30
Diffuse-type giant cell tumor. (16641758)
2006
31
Use of short implants for functional restoration of the mandible after giant cell tumor removal. Case report. (16688107)
2006
32
Morselized and structural cortical allograft reconstruction after intralesional curettage of a distal femoral giant-cell tumor. (16924858)
2006
33
Multicentric, synchronous giant-cell tumor of bone. (16598336)
2006
34
Osteoclastomalike giant cell tumor of the parotid gland: report of a case with fine needle aspiration diagnosis. (16514845)
2006
35
Giant cell tumor of bone. (16311110)
2006
36
Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor. (15923579)
2005
37
Giant cell tumors: inquiry into immunohistochemical expression of CD117 (c-Kit), microphthalmia transcription factor, tartrate-resistant acid phosphatase, and HAM-56. (15737031)
2005
38
Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of bone. (15193543)
2004
39
Metatarsal giant cell tumors and giant cell reparative granuloma are similar entities. (14646771)
2003
40
RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. (11863217)
2002
41
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
42
Downregulation of glutamate receptor subunit 2(3) in subependymal giant-cell tumor. (10963968)
2000
43
Diffuse variant tenosynovial giant cell tumor of the temporomandibular joint: report of a case. (9710197)
1998
44
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. (7689482)
1993
45
Cherubism: diagnosis, treatment, and comparison with central giant cell granulomas and giant cell tumors. (1545971)
1992
46
Telomeric associations and consistent growth factor overexpression detected in giant cell tumor of bone. (1756472)
1991
47
Osteoclast-like giant cell tumor of the pancreas: immunophenotypic similarity to giant cell tumor of bone. (1864595)
1991
48
Malignant giant cell tumor of tendon sheath. Report of a case. (2994359)
1985
49
Benign giant cell tumor or localized osteitis fibrosa cystica. (14846598)
1950
50
VON RECKLINGHAUSEN'S DISEASE OR OSTEITIS FIBROSA: WITH REPORT OF A CASE PRESENTING MULTIPLE CYSTS AND GIANT-CELL TUMORS. (17864590)
1922

Variations for Giant Cell Tumor

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Expression for genes affiliated with Giant Cell Tumor

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Expression patterns in normal tissues for genes affiliated with Giant Cell Tumor

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Pathways for genes affiliated with Giant Cell Tumor

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Pathways related to Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CCNA2, TP53
29.2CCNA2, TP53
3
Show member pathways
9.0FGF3, NF1, CSF1
4
Show member pathways
Signaling Pathways in Glioblastoma37
8.5TP53, NF1, FGF3
5
Show member pathways
MAPK signaling pathway37
8.5TP53, NF1, FGF3
68.3FGF3, CSF1, COL6A3, TP53
7
Show member pathways
7.9DES, TP53, COL6A3, CSF1, NF1

Compounds for genes affiliated with Giant Cell Tumor

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Compounds related to Giant Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1orcein4410.0S100B, ACTC1, DES
2s 1004410.0S100B, DES, ACTC1
3reticulin4410.0DES, ACTC1, S100B
4mucicarmine4410.0DES, ACTC1, S100B
5b 723449.9DES, S100B, ACTC1
6hematoxylin449.9ACTC1, DES, S100B
7procollagen449.8DES, ACTC1, ACP5
8imatinib44 50 1111.6S100B, CSF1, ACTC1, DES
9biotin44 24 1111.5DES, CSF1, ACTC1
10bromodeoxyuridine449.5CCNA2, ACP5, S100B, DES
11iron44 2410.4ACP5, ACTC1, DES, S100B
121,25 dihydroxy vitamin d3449.3CLU, ACP5, CSF1
13cyclosporin a44 28 6111.3S100B, ACP5, ACTC1, CCNA2
14creatinine449.2ACTC1, ACP5, CSF1, S100B, DES
15adpribose449.2TP53, DES, CCNA2
16glycogen44 2410.2S100B, CSF1, ACTC1, CCNA2, DES
17estradiol44 24 1111.2ACP5, DES, CLU, CCNA2
18hydroxyurea44 50 1111.1TP53, CCNA2, CSF1
19colchicine44 61 2 28 1113.0NF1, CCNA2, CLU, S100B
20rapamycin449.0CSF1, NF1, CCNA2, ACP5
21ethanol44 50 24 1112.0S100B, CCNA2, CLU, DES, ACP5
22fatty acid448.8S100B, NF1, CLU, DES
23adenylate448.8DES, CCNA2, CSF1, S100B, NF1
24actinomycin d448.7DES, CSF1, CLU, TP53
25lysine448.7CSF1, NF1, CCNA2, DES
26testosterone44 61 24 1111.7DES, S100B, CSF1, ACTC1, CLU, CCNA2
27lactate448.7CSF1, DES, CLU, S100B
28oxygen44 249.7CCNA2, ACTC1, ACP5, S100B, DES, CLU
29butyrate448.7CLU, TP53, CCNA2, CSF1
30dexamethasone44 50 28 1111.6CCNA2, CLU, ACTC1, ACP5, CSF1, S100B
31dopamine44 28 24 1111.6CCNA2, CLU, NF1, S100B
32heparin44 28 24 1111.5ACP5, CLU, CSF1, S100B, FGF3, DES
33proline448.5CLU, TP53, DES, S100B, CCNA2
34doxorubicin44 50 1110.5TP53, CLU, CCNA2, DES, CSF1
35etoposide44 50 61 1111.4CSF1, S100B, CCNA2, CLU, TP53
36paclitaxel44 50 1110.4TP53, S100B, CSF1, CCNA2, CLU
37cysteine448.4NF1, ACP5, CLU, DES, CSF1, S100B
38thymidine44 249.2CSF1, CCNA2, CLU, TP53, DES, S100B
39h2o2448.1ACP5, CLU, TP53, DES, CCNA2, CSF1
40arginine448.0DES, TP53, CSF1, S100B, NF1, CCNA2
41calcium44 50 24 1111.0ACP5, ACTC1, CCNA2, CLU, DES, S100B
42steroid447.9S100B, NF1, DES, CLU, CCNA2, ACTC1
43oligonucleotide447.9NF1, CCNA2, CLU, FGF3, TP53
44tyrosine447.7DES, ACTC1, CLU, CSF1, ACP5, S100B
45serine447.5CLU, CCNA2, DES, CSF1, S100B, NF1
46vegf447.4FGF3, CSF1, S100B, ACTC1, CCNA2, CLU
47progesterone44 28 61 24 1111.3DES, NF1, S100B, CSF1, ACTC1, CCNA2
48retinoic acid44 248.3CSF1, ACTC1, CCNA2, CLU, TP53, S100B
49paraffin446.9CCNA2, CLU, DES, ACTC1, ACP5, CSF1
50estrogen446.9ACTC1, S100B, CSF1, NF1, ACP5, CCNA2

GO Terms for genes affiliated with Giant Cell Tumor

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Cellular components related to Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5S100B, CSF1, COL6A3, ACTC1, CLU

Biological processes related to Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.8DES, ACTC1
2release of cytochrome c from mitochondriaGO:0018369.2TP53, CLU
3negative regulation of neuroblast proliferationGO:0074069.2TP53, NF1
4positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.1CLU, TP53
5negative regulation of fibroblast proliferationGO:0481479.1NF1, TP53
6cell proliferationGO:0082839.0S100B, CSF1, TP53
7innate immune responseGO:0450878.9FGF3, S100B, CSF1, CLU
8Ras protein signal transductionGO:0072658.8NF1, CCNA2, TP53
9positive regulation of neuron apoptotic processGO:0435258.7NF1, TP53
10positive regulation of apoptotic processGO:0430658.4NF1, S100B, CLU, TP53

Products for genes affiliated with Giant Cell Tumor

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Sources for Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet