MCID: GNT008
MIFTS: 60

Giant Cell Tumor malady

Cancer diseases category

Summaries for Giant Cell Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Giant-cell tumor of the bone (GCTOB) is a relatively uncommon tumor of the bone. It is characterized by... more...

MalaCards: Giant Cell Tumor, also known as giant cell tumors, is related to pigmented villonodular synovitis and synovitis. An important gene associated with Giant Cell Tumor is DES (desmin), and among its related pathways are Osteoclast differentiation and Osteoclast Signaling. The compounds calcium and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and lung, and related mouse phenotypes are homeostasis/metabolism and skeleton.

Aliases & Classifications for Giant Cell Tumor

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

giant cell tumor 8 10
giant cell tumors 8 44 60
tumor of the giant cell 8
carcinoma giant cell 44
giant cell tumor nos 8
giant cell neoplasm 8


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Disease Ontology8 DOID:200
MeSH34 D005870
NCIt39 C7069, C3055

Related Diseases for Giant Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.0CSF1
2synovitis31.0TNFSF11, TNFRSF11B
3paget's disease of bone30.7TNFRSF11A, CALCA
4cystadenocarcinoma30.6CEACAM3
5osteosarcoma30.5ACP5, PLAUR, CTSK, TNFRSF11B, TNFSF11, TNFRSF11A
6sarcoma30.5CCNA2, CALB2, S100B, CSF1, DES, MYOG
7adenocarcinoma30.4CCNA2, CA2, CALB2, TNFSF11, PLAUR, ACTC1
8chondrosarcoma30.4CEACAM3, SERPINA3, DES, CTSK, S100B
9hyperparathyroidism30.4CALCA, TNFSF11, TNFRSF11B, FGF23, ACP5
10cherubism30.4CALCA, TNFSF11
11giant cell reparative granuloma30.3CALCA, TNFRSF11A
12leiomyosarcoma30.2CALB2, S100B, DES, MYOG, ACTC1
13bone carcinoma30.2CEACAM3, TNFRSF11B, TNFSF11, TNFRSF11A, CSF1
14bladder carcinoma30.2CCNA2, CSF1, PLAUR
15thyroiditis30.2CALCA
16pancreatitis30.2CA2
17primary hyperparathyroidism30.2CALCA, FGF23, ACP5
18squamous cell carcinoma30.2CCNA2, CALB2, PLAUR, ACTC1, SERPINA3, CEACAM3
19hemangioma30.2ACTC1
20melanoma30.0CEACAM3, SERPINA3, PTPRC, ACTC1, PLAUR, DES
21osteoarthritis30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK
22arthritis30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK
23rheumatoid arthritis30.0CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK, ACP5
24myeloma30.0CCNA2, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK
25hypercalcemia30.0CALCA, CSF1, TNFRSF11A, TNFSF11, TNFRSF11B, FGF23
26fibrous histiocytoma30.0S100B, DES, ACTC1, SERPINA3
27adenoma30.0CCNA2, CALCA, CALB2, ACTC1, CEACAM3
28microphthalmia30.0S100B, TNFSF11, ACTC1, ACP5
29spindle cell sarcoma30.0S100B, DES, ACTC1
30chordoma30.0CEACAM3, DES, S100B
31multiple myeloma30.0TNFRSF11B, TNFSF11
32osteomyelitis30.0TNFSF11, CTSK, ACP5
33hepatocellular carcinoma30.0CCNA2, TNFSF11, PLAUR, ACP5, CEACAM3
34pleomorphic adenoma30.0S100B, DES, ACTC1
35neuropathy30.0MYOG, CALCA
36osteomalacia30.0FGF23, TNFRSF11B, CALCA
37spindle cell carcinoma30.0ACTC1, DES
38thyroid cancer30.0PLAUR, TNFRSF11B, CALCA
39fibrosarcoma30.0DES, PLAUR, ACTC1
40bone giant cell tumor11.2
41malignant giant cell tumor11.0
42tenosynovial giant cell tumor10.9
43villonodular synovitis10.7
44malignant giant cell tumor of soft parts10.6
45malignant giant cell tumor of the tendon sheath10.4
46bone giant cell sarcoma10.4
47tuberous sclerosis10.4
48cervicitis10.4
49nodular tenosynovitis10.4
50mucinous cystadenocarcinoma10.4

Graphical network of the top 20 diseases related to Giant Cell Tumor:



Diseases related to giant cell tumor

Clinical Features for Giant Cell Tumor

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Drugs & Therapeutics for Giant Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Giant Cell Tumor

Search CenterWatch for Giant Cell Tumor

Genetic Tests for Giant Cell Tumor

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Anatomical Context for Giant Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Giant Cell Tumor:

32
Bone, Monocytes, Lung, Pancreas, Breast, Skin, Salivary gland, Uterus, Lymph node, Liver, Thyroid, T cells, Ovary, Tongue, Kidney, Spinal cord, Prostate, Smooth muscle, Pancreatic islet, Bone marrow

Animal Models for Giant Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Giant Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.8CA2, TNFSF11, CTSK, CSF1, DES, MYOG
2MP:000539010.8TNFRSF11A, ACP5, FGF23, MYOG, CTSK, TNFRSF11B
3MP:000537810.7CSF1, CTSK, PTPRC, CA2, TNFRSF11A, TNFSF11
4MP:000538810.7CTSK, MYOG, PLAUR, PTPRC, TNFRSF11A
5MP:001076810.6DES, TNFRSF11B, ACTC1, MYOG, CSF1, FGF23
6MP:000537110.6CSF1, FGF23, ACP5
7MP:001077110.5TNFSF11, FGF23, CALCA, MYOG, S100B
8MP:000538710.5TNFRSF11B, FGF23, CCNA2, PTPRC, ACP5, PLAUR
9MP:000539710.3CCNA2, CTSK, CSF1, PTPRC, PLAUR, TNFSF11

Publications for Giant Cell Tumor

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50PubMed
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Articles related to Giant Cell Tumor:

(show top 50)    (show all 758)
idTitleAuthorsYear
1
Everolimus for tumor recurrence after surgical resection for subependymal giant cell astrocytoma associated with tuberous sclerosis complex. (22805244)
2013
2
Multifocal giant cell tumor of the tendon sheath: case report and literature review. (23208660)
2013
3
Golden Bullet-Denosumab: Early Rapid Response of Metastatic Giant Cell Tumor of the Bone. (24072245)
2013
4
Retrospective analysis of patients with rare-site and metastatic giant cell tumor. (24255583)
2013
5
Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT. (22825642)
2012
6
Recurrent giant cell tumor of foot detected by F18-FDG PET/CT. (24019661)
2012
7
Giant epithelial malignancies (Basal cell carcinoma, squamous cell carcinoma): a series of 20 tumors from a single center. (22557850)
2012
8
Giant cell tumor of the parotid gland. (22632893)
2012
9
Radiation therapy for infiltrative giant cell tumor of the tendon sheath. (22386549)
2012
10
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. (21924561)
2011
11
A short-term in vivo model for giant cell tumor of bone. (21668953)
2011
12
En bloc excision and autogenous fibular reconstruction for aggressive giant cell tumor of distal radius: a report of 12 cases and review of literature. (21385393)
2011
13
Midfoot reconstruction for a large, aggressive giant-cell tumor: a case report. (22262393)
2011
14
Giant cell tumor of the common bile duct. (19765676)
2010
15
Giant cell tumor of the pancreas: a pathological diagnosis with poor prognosis. (20688610)
2010
16
Recurrence after and complications associated with adjuvant treatments for sacral giant cell tumor. (20623262)
2010
17
Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells. (20035149)
2010
18
P53 expression as a prognostic marker in giant cell tumor of bone: a pilot study. (20506947)
2010
19
Giant cell tumor arising from anterior arc of first rib: a rare presentation. (22049831)
2010
20
Osteoclast-like giant cell tumor arising in the soft tissue of the breast: report of a case. (19132468)
2009
21
Outcome of conservative surgery for giant cell tumor of the sacrum. (19404178)
2009
22
Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma? (20043822)
2009
23
Giant cell tumor of the sphenoid. (19139314)
2009
24
Surgical treatment of multifocal giant cell tumor of carpal bones with preservation of wrist function: case report. (19135808)
2009
25
Distal ulna giant cell tumor resection with reconstruction using distal ulna prosthesis and brachioradialis wrap soft tissue stabilization. (19370378)
2009
26
Treatment of giant cell tumor of long bones: clinical outcome and reconstructive strategy for lower and upper limbs. (19634852)
2009
27
Hip pain, instability caused by labral tears, and an acetabular giant cell tumor. (19404191)
2009
28
Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. (17527089)
2007
29
Pulmonary metastasis of giant cell tumor of the bone diagnosed by fine-needle aspiration biopsy. (17497658)
2007
30
Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. (16825116)
2006
31
Metastasis of giant cell tumor to the breast: case report and review of the literature. (17036529)
2006
32
Giant cell tumor of the sternum. (17037398)
2006
33
Complete necrosis of a spinal giant cell tumor after vertebroplasty. (16614158)
2006
34
Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear. (16877937)
2006
35
Hip joint remodeling in an adult following excision of a giant cell tumor involving the acetabulum: a case report and literature review. (16810549)
2006
36
Impact severity of local recurrence in giant cell tumor of bone. (16131879)
2005
37
Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis. (12874763)
2003
38
Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions. (12850503)
2003
39
RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. (11863217)
2002
40
Composite dermatofibrosarcoma protuberans-giant cell fibroblastoma recurring as BednA!r tumor-giant cell fibroblastoma with mucoid lakes and with amputation neuroma. (12629865)
2002
41
Peripheral T-cell lymphoma with Toutonlike tumor giant cells associated with HIV infection: report of two cases. (10328082)
1999
42
Giant cell tumor of the sphenoid bone. (17171058)
1998
43
Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. (9403714)
1997
44
Proliferation index and vascular density of giant cell tumors of bone: are they prognostic markers? (8640668)
1996
45
Cherubism: diagnosis, treatment, and comparison with central giant cell granulomas and giant cell tumors. (1545971)
1992
46
Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis. (1319390)
1992
47
Fine-needle aspiration cytology of osteoclastic giant-cell tumor of the pancreas. (1705496)
1990
48
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
49
Benign osteoblastoma; a category of osteoid-and bone-forming tumors other than classical osteoid osteoma, which may be mistaken for giant-cell tumor or osteogenic sarcoma. (13364889)
1956
50
VON RECKLINGHAUSEN'S DISEASE OR OSTEITIS FIBROSA: WITH REPORT OF A CASE PRESENTING MULTIPLE CYSTS AND GIANT-CELL TUMORS. (17864590)
1922

Genetic Variations for Giant Cell Tumor

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Expression for genes affiliated with Giant Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Giant Cell Tumor

Search GEO for disease gene expression data for Giant Cell Tumor.

Pathways for genes affiliated with Giant Cell Tumor

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Giant Cell Tumor

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Giant Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.2TNFRSF11A, DES, CTSK, TNFRSF11B, TNFSF11, S100B
2tyrosine4411.2CEACAM3, PTPRC, ACP5, ACTC1, PLAUR, TNFRSF11A
3oxygen44 2412.1TNFRSF11A, S100B, CEACAM3, CA2, CCNA2, ACP5
4paraffin4411.1PLAUR, MYOG, DES, TNFSF11, CSF1, S100B
5vegf4411.1TNFSF11, CSF1, S100B, CALCA, CCNA2, ACTC1
6steroid4411.1MYOG, TNFSF11, S100B, CALB2, CA2, CCNA2
7nitric oxide44 11 2413.1TNFRSF11B, TNFSF11, DES, MYOG, TNFRSF11A, CEACAM3
8creatinine4411.1CEACAM3, SERPINA3, ACTC1, PLAUR, FGF23, TNFRSF11B
9testosterone44 59 11 2414.1S100B, CCNA2, ACTC1, CALCA, CALB2, CSF1
10serine4411.1FGF23, MYOG, SERPINA3, CTSK, TNFRSF11B, TNFRSF11A
11cysteine4411.1CA2, S100B, DES, CSF1, MYOG, ACP5
12heparin44 28 11 2414.1PTPRC, FGF23, DES, TNFRSF11B, TNFSF11, CSF1
13calcitriol44 59 11 2414.0TNFSF11, CALCA, CA2, CSF1, TNFRSF11B, FGF23
14retinoic acid44 2412.0PLAUR, TNFRSF11B, CTSK, MYOG, DES, CA2
15progesterone44 59 28 11 2415.0PTPRC, CSF1, CCNA2, CALB2, TNFRSF11B, DES
16hydroxyapatite4411.0FGF23, CTSK, TNFRSF11B, TNFSF11, TNFRSF11A, S100B
17lipid4411.0CA2, S100B, TNFRSF11A, TNFSF11, TNFRSF11B, SERPINA3
18dexamethasone44 49 28 1114.0S100B, ACP5, TNFSF11, PTPRC, TNFRSF11B, PLAUR
191,25 dihydroxy vitamin d34411.0CALCA, TNFRSF11A, ACP5, FGF23, TNFRSF11B, TNFSF11
20b 7234411.0CALB2, ACTC1, DES, S100B, PTPRC, CEACAM3
21tartrate4411.0ACP5, TNFSF11, CSF1, CALCA, CTSK
22estrogen4411.0CA2, CALB2, MYOG
23cyclosporin a44 28 5912.9PTPRC, ACP5, TNFRSF11B, ACTC1, TNFSF11, S100B
24mucicarmine4410.9DES, S100B, ACTC1, CEACAM3, CALB2
25hematoxylin4410.9CEACAM3, DES, PTPRC, S100B, ACTC1, CALB2
26denosumab44 1111.9TNFSF11, TNFRSF11A, CALCA, TNFRSF11B
27hydrogen44 2411.9TNFSF11, S100B, CEACAM3, ACP5, PTPRC, CTSK
28teriparatide44 1111.9CTSK, TNFRSF11B, CALCA, TNFSF11
29polyethylene4410.9TNFSF11, TNFRSF11B, TNFRSF11A, CTSK
3025-hydroxyvitamin d4410.9TNFRSF11B, CALCA, TNFSF11, FGF23, ACP5
31phosphorus4410.9TNFSF11, FGF23, ACP5, CALCA, TNFRSF11B
32vitamin k24410.9TNFRSF11B, TNFSF11, CSF1, CALCA
33aspartate4410.9CA2, CTSK, ACP5, CEACAM3, CCNA2
34celecoxib44 59 28 49 11 2415.8TNFRSF11B, TNFSF11, CSF1, CA2, CCNA2
35clodronate44 49 1112.8CALCA, TNFSF11, TNFRSF11B, ACP5
36acetylcholine44 49 28 11 2414.8CALB2, MYOG, SERPINA3, CALCA
37forskolin44 49 1112.8CCNA2, PLAUR, MYOG, TNFRSF11B, TNFSF11, S100B
38pmma4410.8CALCA, TNFSF11, TNFRSF11B, ACP5
39iron44 2411.8SERPINA3, S100B, ACTC1, PLAUR, ACP5, DES
40procollagen4410.8ACP5, TNFSF11
41glucose4410.8MYOG, PLAUR, ACTC1, SERPINA3, CEACAM3
42gp 1304410.8TNFSF11, TNFRSF11B, PLAUR, CSF1, TNFRSF11A
43zoledronic acid4410.7TNFRSF11B, CALCA, TNFSF11, CTSK
44deoxypyridinoline4410.7CALCA, TNFSF11, ACP5, TNFRSF11B
45strontium ranelate4410.6CTSK, CALCA, TNFSF11
46arginine4410.6SERPINA3, CSF1, DES, FGF23, PLAUR, S100B
47superoxide44 2411.6PTPRC, SERPINA3
48alendronate44 49 1112.5ATP6V1A, TNFRSF11B, CALCA, TNFSF11
49thymidine44 2411.5CEACAM3, PLAUR, DES, CSF1, S100B, CALB2
50orcein4410.2DES, ACTC1, S100B

GO Terms for genes affiliated with Giant Cell Tumor

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16Gene Ontology
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Cellular components related to Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6CALCA, S100B, TNFSF11, TNFRSF11B, CTSK, FGF23
2extracellular spaceGO:00561510.3CALCA, CA2, S100B, CSF1, TNFSF11, TNFRSF11B

Biological processes related to Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1ossificationGO:00150310.8MYOG, TNFSF11, TNFRSF11A, CSF1
2positive regulation of osteoclast differentiationGO:04567210.8CA2, CSF1, TNFSF11
3monocyte chemotaxisGO:00254810.8CALCA, TNFRSF11A, TNFSF11
4bone resorptionGO:04545310.7ACP5, CTSK, TNFSF11
5osteoclast differentiationGO:03031610.7CSF1, TNFRSF11A, TNFSF11
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.7TNFSF11, TNFRSF11A
7TNFSF11-mediated signaling pathwayGO:07184710.7TNFSF11, TNFRSF11A
8positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.6TNFSF11, TNFRSF11A
9osteoclast proliferationGO:00215810.6TNFSF11
10mammary gland alveolus developmentGO:06074910.5TNFSF11, TNFRSF11A
11negative regulation of bone resorptionGO:04577910.5CALCA, TNFRSF11B
12positive regulation of macrophage differentiationGO:04565110.4CSF1, CALCA
13positive regulation of bone resorptionGO:04578010.2TNFSF11, CA2

Products for genes affiliated with Giant Cell Tumor

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Sources for Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet