MCID: GNT008
MIFTS: 49

Giant Cell Tumor malady

Categories: Cancer diseases

Aliases & Classifications for Giant Cell Tumor

Aliases & Descriptions for Giant Cell Tumor:

Name: Giant Cell Tumor 12 14
Giant Cell Tumors 12 52 42 69
Tumor of the Giant Cell 12
Giant Cell Tumor Nos 12
Giant Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:200
MeSH 42 D005870
NCIt 47 C3055 C7069
UMLS 69 C0017525

Summaries for Giant Cell Tumor

MalaCards based summary : Giant Cell Tumor, also known as giant cell tumors, is related to malignant giant cell tumor of the tendon sheath and malignant giant cell tumor. An important gene associated with Giant Cell Tumor is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Xgeva and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include bone, pancreas and breast, and related phenotypes are limbs/digits/tail and muscle

Related Diseases for Giant Cell Tumor

Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
id Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor of the tendon sheath 33.5 PTPRC SERPINA3
2 malignant giant cell tumor 33.1 ACP5 CSF1 MMP9 PTPRC TNFSF11
3 mucinous cystadenocarcinoma 30.0 ACTC1 MUC1
4 osteomyelitis 29.4 ACTC1 DES VIM
5 rheumatoid arthritis 28.5 ACP5 BGLAP CSF1 CTSK TNFRSF11A TNFRSF11B
6 bone giant cell tumor 12.4
7 tenosynovial giant cell tumor 12.2
8 malignant giant cell tumor of soft parts 12.1
9 osteoclast-like giant cell neoplasm of the pancreas 12.0
10 osteoclastic giant cell tumor of pancreas 11.9
11 pigmented villonodular synovitis 11.5
12 bone giant cell sarcoma 11.5
13 nodular tenosynovitis 11.2
14 cherubism 11.2
15 paget disease of bone 6 10.9
16 lymphomatoid papulosis 10.3 ACTC1 VIM
17 chest wall parachordoma 10.3 ACTC1 VIM
18 chiasmal syndrome 10.3 ACP5 ACTC1 PTPRC
19 hemangioma of liver 10.3 ACP5 ACTC1 PTPRC
20 isolated anterior cervical hypertrichosis 10.3 ACTC1 SERPINA3 VIM
21 hinman syndrome 10.3 PTPRC VIM
22 ribbing disease 10.2 PTPRC VIM
23 glossopharyngeal nerve disease 10.2 CSF1 PTPRC SERPINA3
24 stickler syndrome 10.2 CALCA TNFRSF11B
25 extrahepatic bile duct leiomyosarcoma 10.2 TNFRSF11A TNFSF11
26 myofascial pain syndrome 10.2 ACP5 CALCA CTSK
27 synovitis 10.2
28 central nervous system adult germ cell tumor 10.2 MMP9 VIM
29 oral erosive lichen 10.2 ACTC1 DES
30 villonodular synovitis 10.2
31 carbon monoxide-induced parkinsonism 10.2 ACTC1 DES
32 classic type lipoma 10.2 ACP5 CTSK TNFSF11
33 inflammatory linear verrucous epidermal nevus 10.2 DES VIM
34 peripheral scars of retina 10.2 TNFRSF11B TNFSF11
35 immunodeficiency due to a classical component pathway complement deficiency 10.2 MUC1 VIM
36 corneal staphyloma 10.2 ACP5 CTSK MMP9
37 onychocytic matricoma 10.2 MMP9 SERPINA3 VIM
38 conjunctival cancer 10.2 ACTC1 MUC1 VIM
39 testicular granulosa cell tumor 10.2 ACTC1 MUC1 VIM
40 lymphangiosarcoma 10.1 ACTC1 MUC1 VIM
41 lymphomatous thyroiditis 10.1 DES VIM
42 cauda equina intradural extramedullary astrocytoma 10.1 ACTC1 MUC1 VIM
43 plasma protein metabolism disease 10.1 CSF1 TNFSF11
44 chromosome 16q22 deletion syndrome 10.1 CALCA TNFRSF11A TNFSF11
45 cutis laxa 10.1 CSF1 SERPINA3
46 popliteal pterygium syndrome, bartsocas-papas type 10.1 ACTC1 MUC1 VIM
47 autosomal recessive stickler syndrome 10.1 MUC1 VIM
48 13q12.3 microdeletion syndrome 10.1 ACTC1 DES VIM
49 appendix mucinous cystadenocarcinoma 10.1 MUC1 PTPRC VIM
50 osteopetrosis, autosomal recessive 7 10.1 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Giant Cell Tumor:



Diseases related to Giant Cell Tumor

Symptoms & Phenotypes for Giant Cell Tumor

MGI Mouse Phenotypes related to Giant Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.63 CSF1 CTSK MMP9 TNFRSF11A TNFRSF11B TNFSF11
2 muscle MP:0005369 9.5 DES MMP9 TNFSF11 VIM ACTC1 ADAM12
3 respiratory system MP:0005388 9.17 CSF1 CTSK MMP9 PTPRC TNFRSF11A TNFSF11

Drugs & Therapeutics for Giant Cell Tumor

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Xgeva 17 46 DENOSUMAB Amgen Approved June 2013/ Approved November 2010

Drugs for Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 375)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
5 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
6 Antifungal Agents Phase 4,Phase 2,Phase 3,Phase 1
7 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
8 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
9
Carmustine Approved Phase 3,Phase 2,Phase 1 154-93-8 2578
10
Lomustine Approved Phase 3,Phase 1 13010-47-4 3950
11
Procarbazine Approved Phase 3,Phase 1,Phase 2 671-16-9 4915
12
Trioxsalen Approved Phase 3,Phase 1 3902-71-4 5585
13
Infliximab Approved Phase 3 170277-31-3
14
Dacarbazine Approved, Investigational Phase 3,Phase 1,Phase 2 4342-03-4 5351166
15
Temozolomide Approved, Investigational Phase 3,Phase 1,Phase 2 85622-93-1 5394
16
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
17
Vincristine Approved, Investigational Phase 3,Phase 1,Phase 2 2068-78-2, 57-22-7 5978
18
Leflunomide Approved, Investigational Phase 3 75706-12-6 3899
19
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
20
Morphine Approved, Investigational Phase 3 57-27-2 5288826
21
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
22
Etanercept Approved, Investigational Phase 3 185243-69-0
23
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
24
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
25
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
26
Isotretinoin Approved Phase 3,Phase 2,Phase 1 4759-48-2 5538 5282379
27
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
28
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
29
Ondansetron Approved Phase 3 99614-02-5 4595
30
Prednisone Approved, Vet_approved Phase 3,Phase 1,Phase 2 53-03-2 5865
31
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
32
Cyproheptadine Approved Phase 3 129-03-3 2913
33
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
35
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
36
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2,Phase 1 302-79-4 5538
37 Alkylating Agents Phase 3,Phase 1,Phase 2
38 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
39 Dermatologic Agents Phase 3,Phase 2,Phase 1
40 Dihematoporphyrin Ether Phase 3,Phase 1
41 Ether Phase 3
42 Photosensitizing Agents Phase 3,Phase 2,Phase 1
43 Antirheumatic Agents Phase 3,Phase 1,Phase 2
44 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
45 Analgesics Phase 3,Phase 2,Phase 1
46 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
47 Liver Extracts Phase 3,Phase 2,Phase 1
48 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
49 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
50 Analgesics, Non-Narcotic Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 406)
id Name Status NCT ID Phase
1 Long-term Follow-up for Growth and Development of Pediatric Patients From CRAD001M2301 Active, not recruiting NCT02338609 Phase 4
2 Surgery, Radiation Therapy, and Chemotherapy With or Without Photodynamic Therapy in Treating Patients With Newly Diagnosed or Recurrent Malignant Supratentorial Gliomas Unknown status NCT00003788 Phase 3
3 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3
4 Efficacy of RAD001/Everolimus in Autism and NeuroPsychological Deficits in Children With Tuberous Sclerosis Complex Unknown status NCT01730209 Phase 2, Phase 3
5 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
6 Radiation Therapy Plus Chemotherapy in Treating Patients With Supratentorial Glioblastoma Multiforme Completed NCT00002545 Phase 3
7 Radiation Therapy (RT) and Temozolomide (TMZ) in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma Completed NCT00304031 Phase 3
8 Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00482677 Phase 3
9 S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma Completed NCT00017147 Phase 3
10 Radiation Therapy With or Without Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00006353 Phase 3
11 Standard Radiation Therapy, Higher-Dose Radiation Therapy, or Chemotherapy in Treating Older Patients With Glioblastoma Multiforme Completed NCT00820963 Phase 3
12 High Light and Low Light Dose PDT in Glioma Completed NCT00118222 Phase 3
13 Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma Completed NCT01480479 Phase 3
14 Standard Radiation Therapy With or Without Stereotactic Radiation Therapy in Treating Patients With Glioma Completed NCT00003916 Phase 3
15 Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma Completed NCT00052455 Phase 3
16 SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme Completed NCT00003293 Phase 3
17 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
18 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3
19 Efficacy and Safety of Everolimus (RAD001) in Patients of All Ages With Subependymal Giant Cell Astrocytoma Associated With Tuberous Sclerosis Complex (TSC)(EXIST-1) Completed NCT00789828 Phase 3
20 Etanercept Treatment in the Early Course of Polymyalgia Rheumatica Completed NCT00524381 Phase 3
21 Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) Completed NCT00790400 Phase 3
22 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3
23 Temozolomide (TMZ) and Radiation Therapy (RT) With or Without Bevacizumab in Treating Patients With Newly Diagnosed Glioblastoma Multiforme (GBM) Active, not recruiting NCT00884741 Phase 3
24 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Active, not recruiting NCT01346267 Phase 3
25 An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA) Active, not recruiting NCT01791153 Phase 3
26 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
27 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3
28 Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3
29 Single Arm Trial With Combination of Everolimus and Letrozole in Treatment of Platinum Resistant Relapse or Refractory or Persistent Ovarian Cancer/Endometrial Cancer Unknown status NCT02188550 Phase 2
30 Hydroxychloroquine, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Unknown status NCT00486603 Phase 1, Phase 2
31 Radiation Therapy Plus Hyperbaric Oxygen in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Unknown status NCT00006460 Phase 1, Phase 2
32 Radiation Therapy, Temozolomide, Tamoxifen, and Carboplatin in Treating Patients With Malignant Gliomas Unknown status NCT00492687 Phase 2
33 Temozolomide, Thalidomide, and Celecoxib Following Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Unknown status NCT00047294 Phase 2
34 Erlotinib in Treating Patients With Recurrent or Progressive Glioblastoma Multiforme Unknown status NCT00054496 Phase 2
35 Antineoplaston Therapy in Treating Patients With Glioblastoma Multiforme Unknown status NCT00003456 Phase 2
36 Combination Chemotherapy in Treating Patients With Recurrent Glioblastoma Multiforme Unknown status NCT00014105 Phase 1, Phase 2
37 Carmustine in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme Unknown status NCT00006656 Phase 2
38 Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm Unknown status NCT00009854 Phase 1, Phase 2
39 Temozolomide and Carmustine in Treating Patients With Anaplastic Glioma Unknown status NCT00003176 Phase 2
40 Thalidomide, Celecoxib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Malignant Glioma Unknown status NCT00047281 Phase 2
41 Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma Unknown status NCT00045110 Phase 1, Phase 2
42 Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma Unknown status NCT01026493 Phase 1, Phase 2
43 Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone Completed NCT00396279 Phase 2
44 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2
45 Everolimus (RAD001) Therapy of Giant Cell Astrocytoma in Patients With Tuberous Sclerosis Complex Completed NCT00411619 Phase 1, Phase 2
46 Imatinib Mesylate in Treating Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans or Giant Cell Fibroblastoma Completed NCT00085475 Phase 2
47 Stereotactic Radiosurgery and Radiation Therapy in Treating Patients With Glioblastoma Multiforme Completed NCT00253448 Phase 2
48 Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors Completed NCT00039494 Phase 2
49 Vorinostat in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme Completed NCT00238303 Phase 2
50 Cilengitide in Treating Patients Who Are Undergoing Surgery for Recurrent or Progressive Glioblastoma Multiforme Completed NCT00112866 Phase 2

Search NIH Clinical Center for Giant Cell Tumor

Cochrane evidence based reviews: giant cell tumors

Genetic Tests for Giant Cell Tumor

Anatomical Context for Giant Cell Tumor

MalaCards organs/tissues related to Giant Cell Tumor:

39
Bone, Pancreas, Breast, Salivary Gland, Uterus, Lung, Skin

Publications for Giant Cell Tumor

Articles related to Giant Cell Tumor:

(show top 50) (show all 849)
id Title Authors Year
1
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
2
Primary giant cell tumor of the female breast: a diagnostic red herring with therapeutic implications. ( 27862328 )
2017
3
Giant cell tumor of soft tissue is genetically distinct from its bone counterpart. ( 28084336 )
2017
4
Ultrasonography role in the evaluation of a giant cell tumor of the flexor pollicis longus tendon. ( 27151725 )
2016
5
Epidemiological study on giant cell tumor recurrence at the Brazilian National Institute of Traumatology and Orthopedics. ( 27517027 )
2016
6
Case Report of the positive exostosin-1 without B-cell lymphoma-2 gene expression of giant cell tumor lesion in hereditary multiple exostosis. ( 27846455 )
2016
7
The interdisciplinary approach of an aggressive giant cell tumor of bone complicated with a fracture of the distal femur. ( 27516036 )
2016
8
Histologic Spectrum of Giant Cell Tumor (GCT) of Bone in Patients 18 Years of Age and Below: A Study of 63 Patients. ( 27526293 )
2016
9
A solitary pleural metastasis of benign giant cell tumor of bone. ( 27516881 )
2016
10
Giant Cell Tumor of Midface: A Rare Aggressive Entity With an Easy Solution That Even Caters for Recurrence. ( 27648650 )
2016
11
Giant cell tumor of bone arising in long bones possibly originates from the metaphyseal region. ( 27073530 )
2016
12
Diffuse Type Tenosynovial Giant Cell Tumor of the Ankle. ( 26996490 )
2016
13
Clinical and Radiographic Results of Reconstruction with Fibular Autograft for Distal Radius Giant Cell Tumor. ( 27384728 )
2016
14
Role of Denosumab in Endoscopic Endonasal Treatment for Juvenile Clival Giant Cell Tumor: A Case Report and Review of the Literature. ( 27113403 )
2016
15
A case of thoracic giant cell tumor of bone and discussion of radiological features and current management practices. ( 27594954 )
2016
16
Giant Cell Tumor of Talus: T-Construct Method of Bone Grafting. ( 27885101 )
2016
17
Multiple Brown Tumors Caused by a Parathyroid Adenoma Mimicking Metastatic Bone Disease from Giant Cell Tumor. ( 26912981 )
2016
18
Characterization of MicroRNA Expression Profiles in Patients with Giant Cell Tumor. ( 27384730 )
2016
19
Surgery methods and soft tissue extension are the potential risk factors of local recurrence in giant cell tumor of bone. ( 27094617 )
2016
20
Genome-Wide Transcriptome Profiling of the Neoplastic Giant Cell Tumor of Bone Stromal Cells by RNA Sequencing. ( 27862217 )
2016
21
Remarkable regression of a giant cell tumor of the cervical spine treated conservatively with denosumab: A case report. ( 27179332 )
2016
22
Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type. ( 26755356 )
2016
23
Expression of Matrix Metalloproteinase-9 and CD34 in Giant Cell Tumor of Bone. ( 27384731 )
2016
24
Giant cell tumor of the spine: A rare cause of cervical pain. ( 27068193 )
2016
25
CORR Insights(Ar): Supplemental Bone Grafting in Giant Cell Tumor of the Extremity Reduces Nononcologic Complications. ( 27075332 )
2016
26
A case of giant cell tumor of soft parts in a horse. ( 27391215 )
2016
27
Distal radius reconstruction with vascularized proximal fibular autograft after en-bloc resection of recurrent giant cell tumor. ( 27530935 )
2016
28
Osteoclast-Like Giant Cell Tumor of the Parotid Gland: Report of a Case Diagnosed on Fine-Needle Aspiration Cytology With Histological and Immunohistochemical Findings. ( 27079183 )
2016
29
Recurrent Giant Cell Tumor of Skull Combined with Multiple Aneurysms. ( 27195256 )
2016
30
Tenosynovial Giant Cell Tumor in the Dermis of the External Auditory Meatus. ( 27072732 )
2016
31
Primary osteoclast-like giant cell tumor of parotid gland: A rare extraskeletal presentation with diagnostic challenges. ( 27601838 )
2016
32
Atypical presentation of primary spinal amyloidoma mimicking a giant cell tumor. ( 27841229 )
2016
33
Histopathological, immunohistochemical, and image analytic parameters characterizing the stromal component in primary and recurrent giant cell tumor of bone. ( 27182148 )
2016
34
Clinical effects of three surgical approaches for a giant cell tumor of the distal radius and ulna. ( 27900098 )
2016
35
CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study. ( 27390668 )
2016
36
Abscopal effect of radiotherapy in a patient with metastatic diffuse-type giant cell tumor. ( 27820978 )
2016
37
Population-based study of giant cell tumor of bone in Sweden (1983-2011). ( 27060625 )
2016
38
Giant Cell Tumor with Secondary Aneurysmal Bone Cyst Shows Heterogeneous Metabolic Pattern on (18)F-FDG PET/CT: A Case Report. ( 27994691 )
2016
39
Obstructive hydrocephalus as a result of giant cell tumor of the thoracic spine: A case report. ( 26870164 )
2016
40
What role for radiobiphosphonates bone scintigraphy in the monitoring of an unusual bone giant cell tumor: a case report and literature review. ( 27186440 )
2016
41
Giant Cell Tumor Developing in Paget's Disease of Bone: A Case Report with Review of Literature. ( 28164066 )
2016
42
A massive intrathoracic mass lesion due to giant cell tumor of pleura. ( 27051125 )
2016
43
Interest of Denosumab for the Treatment of Giant-cells Tumors and Aneurysmal Bone Cysts of the Spine. About Nine Cases. ( 27244112 )
2016
44
Coexisting sarcoidal granulomatous inflammation and diffuse tenosynovial giant cell tumor of the knee after a total knee replacement: a case report. ( 27717976 )
2016
45
Multidisciplinary Approach to Management of Temporal Bone Giant Cell Tumor. ( 28078198 )
2016
46
Malignant tenosynovial giant cell tumor with CDKN2A/B genomic alteration: a histological, immunohistochemical, and molecular study. ( 27989786 )
2016
47
Giant cell tumor of the tendon sheath originating from the ankle capsule: A case report and literature review. ( 27123136 )
2016
48
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
49
Regeneration of a Tooth in a Tissue-Engineered Mandible After Resection of a Central Giant Cell Tumor. Demonstrating Evidence of Functional Matrix Theory and Ectodermal Origin of Teeth in a Human Model-A Case Report. ( 27780691 )
2016
50
Morphological and dynamic contrast enhanced MR imaging features for the differentiation of chordoma and giant cell tumors in the Axial Skeleton. ( 27490009 )
2016

Variations for Giant Cell Tumor

Expression for Giant Cell Tumor

Search GEO for disease gene expression data for Giant Cell Tumor.

Pathways for Giant Cell Tumor

Pathways related to Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CSF1 CTSK MMP9 MUC1 PTPRC SERPINA3
2
Show member pathways
13.06 CSF1 MMP9 MUC1 TNFRSF11A TNFRSF11B TNFSF11
3 12.29 ACTC1 DES MUC1 VIM
4
Show member pathways
12.16 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
5 11.77 MMP9 MUC1 VIM
6 11.74 ACP5 CSF1 CTSK TNFRSF11A TNFRSF11B TNFSF11
7
Show member pathways
11.67 ADAM12 CTSK MMP9
8 11.64 BGLAP DES PTPRC
9 11.61 ACP5 CSF1 CTSK TNFRSF11A TNFSF11
10
Show member pathways
11.56 TNFRSF11A TNFRSF11B TNFSF11
11 11.47 ACTC1 DES VIM
12 11.01 BGLAP CALCA TNFRSF11A TNFRSF11B TNFSF11
13 10.64 BGLAP TNFRSF11B TNFSF11
14 10.23 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Giant Cell Tumor

Cellular components related to Giant Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 ACP5 ACTC1 CSF1 DES MMP9 MUC1
2 extracellular region GO:0005576 9.65 ADAM12 BGLAP CALCA CSF1 CTSK MMP9
3 extracellular space GO:0005615 9.36 ACTC1 ADAM12 BGLAP CALCA CSF1 CTSK

Biological processes related to Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 CALCA CSF1 SERPINA3 TNFRSF11A TNFRSF11B
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.75 TNFRSF11A TNFRSF11B TNFSF11
3 monocyte chemotaxis GO:0002548 9.61 CALCA TNFRSF11A TNFSF11
4 positive regulation of osteoclast differentiation GO:0045672 9.58 CSF1 TNFSF11
5 muscle filament sliding GO:0030049 9.58 ACTC1 DES VIM
6 mammary gland alveolus development GO:0060749 9.57 TNFRSF11A TNFSF11
7 intermediate filament organization GO:0045109 9.56 DES VIM
8 macrophage differentiation GO:0030225 9.55 CSF1 MMP9
9 regulation of osteoclast differentiation GO:0045670 9.54 BGLAP TNFSF11
10 response to inorganic substance GO:0010035 9.52 BGLAP TNFRSF11B
11 positive regulation of macrophage differentiation GO:0045651 9.51 CALCA CSF1
12 negative regulation of bone resorption GO:0045779 9.49 CALCA TNFRSF11B
13 TNFSF11-mediated signaling pathway GO:0071847 9.46 TNFRSF11A TNFSF11
14 osteoclast proliferation GO:0002158 9.37 CSF1 TNFSF11
15 osteoclast differentiation GO:0030316 9.33 CSF1 TNFRSF11A TNFSF11
16 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.32 TNFRSF11A TNFSF11
17 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.26 TNFRSF11A TNFSF11
18 bone resorption GO:0045453 9.13 ACP5 CTSK TNFSF11
19 ossification GO:0001503 8.92 BGLAP MMP9 TNFRSF11A TNFSF11

Sources for Giant Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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