Giant Cell Tumor malady

Wikipedia: Giant-cell tumor of the bone (GCTOB) is a relatively uncommon tumor of the bone. It is characterized by...⁴⁴ more...

MalaCards: Giant Cell Tumor, also known as giant cell tumors, is related to bone giant cell tumor and pigmented villonodular synovitis. An important gene associated with Giant Cell Tumor is DES (desmin), and among its related pathways are Glioblastoma Multiforme and TRAIL Pathway. The drugs prednisone and prednisolone tebutate and the compounds glucose and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, liver and lung, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

giant cell tumor 6 8 giant cell tumors 32 43 giant cell tumor nos (morphologic abnormality) 6 giant cell tumors (morphologic abnormality) 6 giant cell tumor (morphologic abnormality) 6

giant cell tumor (qualifier value) 6 tumor of the giant cell 6 giant cell neoplasm 6 neoplasms 43

Diseases related to giant cell tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1608)

id	Related Disease	Score	Top Affiliating Genes
1	bone giant cell tumor	35.4	ATP6V1A, ACP5, RGS12
2	pigmented villonodular synovitis	33.9	BGLAP, CD68, MMP9, CALCR, TNFRSF11B, TNFSF11
3	malignant giant cell tumor of soft parts	33.7	S100B, ACTC1, DES
4	villonodular synovitis	32.7	BGLAP, CD68, MMP9, TNFRSF11B, TNFSF11, ACP5
5	cherubism	32.4	FGFR3, CALCA, TNFSF11, SRC, NF1, CSF1
6	colonic neoplasm	31.5	CLU, CDKN1A, TP53, SRC, CTNNB1
7	fibrous histiocytoma	30.6	SERPINA3, VIM, S100B, CD163, CD34, MITF
8	mucinous cystadenocarcinoma	30.5	VIM, MUC1, CEACAM3, PTPRC, ACTC1
9	tongue cancer	30.4	VIM, VEGFA, MYC, BIRC5, CDKN1A, MMP9
10	salivary gland cancer	30.3	KIT, BIRC5, MMP13, MMP9, MET
11	thyroid cancer	30.2	CALCA, TP63, DYT10, TERT
12	parathyroid carcinoma	30.1	UCHL1, CCND1, CASR, CALCA, TP53, TERT
13	neurofibromatosis	29.9	KIT, S100B, MMP13, NF1, TSC1, TSC2
14	sex cord-gonadal stromal tumor	29.7	VIM, MUC1, S100B, CALB2, DES, PGR
15	microphthalmia	29.6	KIT, S100B, MITF, TNFSF11, DYT10, CTSK
16	basal cell carcinoma	29.5	CD34, MMP13, CCNB1, F13A1, TP53, TP63
17	bone cancer	29.4	ATP6V1A, IL1B, CALCA, ESR1, TNFRSF11A, TNFRSF11B
18	ovarian cancer	29.4	CDKN1A, CCNB1, CCNA2, CCND3, CCND1
19	neuroendocrine tumor	29.0	CEACAM3, CCNB1, IGF1R, IFI27, CALCA, SRC
20	myoma	28.8	GSR, FGF2, CCND1, CALCA, ESR1, TERT
21	perivascular epithelioid cell tumor	28.7	KIT, VIM, MUC1, S100B, MITF, ACTC1
22	follicular dendritic cell tumor	28.7	CLU, S100B, CD68, PTPRC, ACTC1
23	glomus tumor	28.6	VIM, MUC1, S100B, CD34, ACTC1, DES
24	hodgkin's lymphoma	28.5	BSG, CD68, FGFR3, IL7, TNFRSF8, PTPRC
25	lipoma	28.5	VIM, CD34, CD68, TNF, ACTC1, TGFB2
26	ovarian mucinous neoplasm	28.4	MYC, MUC1, CEACAM3, CDKN1A, MMP9, IL1B
27	perineurioma	28.3	KIT, VIM, CLDN7, MUC1, S100B, CD34
28	pleomorphic adenoma	28.2	VIM, MUC1, S100B, TP63, ACTC1, DES
29	cystadenocarcinoma	28.2	VIM, VEGFA, BIRC5, MUC1, CEACAM3, CDKN1A
30	brain cancer	28.2	VEGFA, BIRC5, CLU, CDKN1A, FGF2, CCNB1
31	myelodysplastic syndrome	27.8	KIT, BIRC5, CD33, CD34, ANXA5, ANPEP
32	paget's disease of bone	27.8	BGLAP, FGF2, IL1B, CASR, CALCA, ESR1
33	adenoid cystic carcinoma	27.8	KIT, SERPINA3, VIM, MUC1, S100B, CEACAM3
34	lung benign neoplasm	27.8	UCHL1, GSR, MET, ESR2, TP53, TERT
35	male breast cancer	27.8	ESR1, ESR2, TP53, CTSD, ACPP, PGR
36	paraganglioma	27.7	KIT, VIM, BSG, S100B, CEACAM3, FGF2
37	myelofibrosis	27.7	KIT, BMP6, FGF2, TNFRSF11B
38	adenomatoid tumor	27.7	VIM, MUC1, CALB2, ACPP, DES
39	urinary bladder cancer	27.6	BIRC5, CDKN1A, FGFR3, IFI27, TP53, TERT
40	pleomorphic xanthoastrocytoma	27.6	CD34, CD68, TP53, TSC1
41	pancreatic cancer	27.6	VEGFA, BIRC5, MUC1, CEACAM3, CDKN1A, CCND1
42	malignant peripheral nerve sheath tumor	27.5	KIT, VIM, MUC1, S100B, CD34, MMP13
43	craniopharyngioma	27.5	VIM, CEACAM3, CD34, CCNA2, IGF1R, IGF1
44	dermatofibrosarcoma protuberans	27.5	KIT, VIM, MUC1, S100B, CD163, CD34
45	testicular cancer	27.5	BMP6, CDKN1A, MMP9, FGF2, CCNA2, CCND3
46	b-cell lymphomas	27.3	MYC, BIRC5, CLU, CDKN1A, CD14, CCNB1
47	pancreatic ductal carcinoma	27.3	VEGFA, MUC1, MMP9, IL1B, TP53, EGF
48	hematologic cancer	27.2	KIT, VEGFA, BIRC5, BGLAP, IL7, CCNA2
49	polymorphous low-grade adenocarcinoma	27.2	KIT, VIM, MUC1, S100B, CEACAM3, TP63
50	histiocytoma	27.1	SERPINA3, VIM, BSG, VEGFA, MYOG, MUC1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to giant cell tumor:

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MGI Mouse Phenotypes related to giant cell tumor:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	F13A1, FGF23, CD14, MYOG, CALCA, TP63
2	endocrine/exocrine gland phenotype	MP:0005379	10.2	MITF, TP63, RUNX2, CSF1R, NF1, CTSK
3	craniofacial phenotype	MP:0005382	9.9	RUNX2, CSF1, TWIST1, NF1, CTSK, PTH
4	liver/biliary system phenotype	MP:0005370	9.7	TSC2, NF1, CTSL1, PTPRC, TP53, ESR2
5	other phenotype	MP:0005395	9.6	NF1, CTSL1, CTSB, CTSK, PTGS2, ESR2
6	renal/urinary system phenotype	MP:0005367	8.8	TSC2, TSC1, NF1, CTSL1, CTSB, CTNNB1
7	hematopoietic system phenotype	MP:0005397	8.6	KRT8, CALCR, F13A1, CCND1, CCNA2, FGFR3
8	behavior/neurological phenotype	MP:0005386	8.3	PGR, CSF1R, DES, TSC2, TSC1, TWIST1
9	limbs/digits/tail phenotype	MP:0005371	8.1	RUNX2, CSF1R, CSF1, TGFB2, TP63, ESR2
10	embryogenesis phenotype	MP:0005380	8.1	SRC, CTNNB1, NF1, KRT8, TWIST1, TIE1
11	hearing/vestibular/ear phenotype	MP:0005377	7.9	ESR2, TNFRSF11B, CTNNB1, CTSL1, NF1, TGFB2
12	normal phenotype	MP:0002873	7.4	CALCR, ESR2, TP63, TERT, PTPRC, CTSB
13	no phenotypic analysis	MP:0003012	7.3	ESR2, TP53, TNFRSF10B, PTGS2, CTNNB1, KTN1
14	immune system phenotype	MP:0005387	7.3	NF1, PLAUR, CTSB, CTSK, CTSD, SRC
15	integument phenotype	MP:0010771	7.0	CTSL1, CTSB, CTNNB1, SRC, TNFSF11, TNFRSF11A
16	reproductive system phenotype	MP:0005389	7.0	PTGS2, FGF2, MMP9, VEGFA, FGF23, FGF3
17	mortality/aging	MP:0010768	6.9	POT1, CTSB, CTSD, PTH, TEK, TNFSF11
18	nervous system phenotype	MP:0003631	6.4	TWIST1, CALB2, CCND1, GRM4, FGFR3, FGF3
19	growth/size phenotype	MP:0005378	6.1	PTH, CCND3, MET, FGFR3, FGF3, FGF23
20	adipose tissue phenotype	MP:0005375	6.0	ESR2, TP53, TNF, PTGS2, TGFB1, ADAM12
21	digestive/alimentary phenotype	MP:0005381	5.5	TWIST1, CA2, CASR, IGF1R, CCL2, MET
22	vision/eye phenotype	MP:0005391	5.4	TP63, MMP9, CDKN1A, CEBPB, MUC1, VEGFA
23	skeleton phenotype	MP:0005390	4.9	TNFRSF11A, FGF3, FGF23, FGF2, MITF, MMP9
24	muscle phenotype	MP:0005369	4.5	TSC1, ESR1, CASR, IGF1, IGF1R, CCL2
25	tumorigenesis	MP:0002006	3.5	CTNNB1, SRC, PTPRC, PTGS2, TERT, TNFSF10
26	cardiovascular system phenotype	MP:0005385	3.3	ADAM12, PGR, TWIST1, ACTC1, KRT8, NF1
27	cellular phenotype	MP:0005384	2.1	TGFB1, TIE1, TSC2, TSC1, TWIST1, ACTC1
28	homeostasis/metabolism phenotype	MP:0005376	2.0	CTSB, TNF, TP63, TP53, ESR2, ESR1

Articles related to giant cell tumor:

(show top 50)    (show all 96)

id	Title	Authors	Year	Affiliating Genes
1	The role of TWIST as a regulator in giant cell tumor of bone. (21503964)	Singh S.... Ghert M.	2011	TWIST1
2	Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone. (20573369)	Mak I.W.... Ghert M.	2010	MMP13
3	Silencing of the UCHL1 gene in giant cell tumors of b one. (20104524)	Fellenberg J.... Witte D.	2010	UCHL1
4	CD33+ CD14- phenotype is characteristic of multinuclear osteoclast-like cells in giant cell tumor of bone. (18767926)	Forsyth R.G.... Hogendoorn P.C.	2009	CD14, CD33
5	Immunohistochemical analyses of beta-catenin and cycl in D1 expression in giant cell tumor of bone (GCTB): a possible role of Wnt pat hway in GCTB tumorigenesis. (19324500)	Matsubayashi S.... Shindo H.	2009	CCND1, CTNNB1
6	Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and h istogenetic implications. (19542874)	Boland J.M.... Grogg K.L.	2009	DES, CLU
7	Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis (19218139)	Luo S.M.... Hou J.H.	2009	PTGS2, BIRC5
8	Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. (17918257)	Moller E.... Panagopoulos I.	2008	COL6A3, CSF1
9	Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone. (18204433)	Horvai A.E.... O'Donnell R.J.	2008	TERT
10	Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex. (18706978)	Boer K.... Aronica E.	2008	TSC1, GRM4
11	Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone. (18192965)	Lee C.H.... West R.B.	2008	TP63
12	Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors. (16465417)	Wang C.... Bian Z.	2006	SRC
13	Diffuse-type tenosynovial giant cell tumor in association with neurofibromatosis type 1-Noonan syndrome: possibly more than a chance relationship. (16723851)	Posligua L.... Dehner L.P.	2006	NF1
14	Cyclin D1 and p21 is elevated in the giant cells of giant cell tumors. (16479604)	Kandel R.... Werier J.	2006	CDKN1A
15	Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. (16825116)	Anazawa U.... Toyama Y.	2006	ACP5
16	Giant cell tumors of the bone: molecular profiling and expression analysis of Ephrin A1 receptor, Claudin 7, CD52, FGFR3 and AMFR. (16325507)	Guenther R.... Sers C.	2005	FGFR3, CLDN7, AMFR
17	Tenosynovial giant cell tumor (15657685)	Kuhnen C.... Herter P.	2005	CALB2
18	Bisphosphonates induce apoptosis of stromal tumor cel ls in giant cell tumor of bone. (15037971)	Cheng Y.Y.... Kumta S.M.	2004	ANXA5
19	Subependymal giant cell tumors in tuberous sclerosis complex. (15505165)	Goh S.... Thiele E.A.	2004	TSC1
20	Decreased expression of transforming growth factor-beta II receptor is associated with that of p27KIP1 in giant cell tumor of bone: a possible link between transforming growth factor-beta and cell cycle-related protein. (14745726)	Kawaguchi K.... Tsuneyoshi M.	2004	TTF2, IFI27
21	Expression and localization of extracellular matrix metalloproteinase inducer in giant cell tumor of bone. (12898514)	Si A.I.... Zheng M.H.	2003	TNFSF11, BSG
22	Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis. (12874763)	Furlong M.A.... Fetsch J.F.	2003	CD163
23	Cyclin alterations in giant cell tumor of bone. (12640100)	Kauzman A.... Kandel R.	2003	CCNB1, CCND3
24	Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesis. (12865629)	Robinson D.... Nevo Z.	2002-2003	TNFRSF11B, FGF3, BGLAP
25	Expression and significance of urokinase-type plasminogen activator, its receptor, and type 2 inhibitor in giant cell tumor of bone (11810768)	Li H.... Zeng Y.	2001	PLAUR
26	Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone. (11336917)	Atkins G.J.... Findlay D.M.	2001	TNFRSF11B, TNFSF11, TNFRSF11A
27	Expression of tyrosine kinase receptors Tie-1 and Tie-2 in giant cell tumor of the tendon sheath: a possible role in synovial proliferation. (11261813)	Nakashima M.... Sekine I.	2001	TEK, CD34, TIE1
28	Expression of osteoclast differentiation signals by stromal elements of giant cell tumors. (10780856)	Atkins G.J.... Findlay D.M.	2000	TNFRSF11B, TNFSF11
29	Spindle-shaped cells derived from giant-cell tumor of bone support differentiation of blood monocytes to osteoclast-like cells. (11052502)	Miyamoto N.... Ito Y.	2000	CSF1
30	Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone. (10547161)	Rao V.H.... Finnell R.H.	1999	MMP9, IL1B
31	Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. (10496598)	Folpe A.L.... Weiss S.W.	1999	S100B, DES, ACTC1
32	Loss of the TSC2 product tuberin in subependymal giant-cell tumors. (10483779)	Arai Y.... Becker L.E.	1999	TSC2
33	Effect of cytokines on in vitro bone resorption by cells isolated from giant cell tumor of bone. (11593516)	Wen J.... Bi J.	1999	CSF1
34	Prognostic relevance of C-myc gene expression in giant-cell tumor of bone. (9565066)	Gamberi G.... Picci P.	1998	MYC
35	Promotive effect of TNF-alpha and M-CSF on osteolysis induced by giant cell tumor of bone (10374334)	Wen J.... Yao J.	1997	TNF, CSF1
36	Mixed osteoclastic/pleomorphic-type giant cell tumor of the pancreas with ductal adenocarcinoma: histochemical and immunohistochemical study with review of the literature. (9260206)	Watanabe M.... Sawai T.	1997	VIM
37	Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone. (9219728)	Rao V.H.... Rao J.S.	1997	MMP9
38	Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation. (8698303)	Teot L.A.... Hicks D.G.	1996	TGFB2
39	The prognostic significance of histomorphometry and immunohistochemistry in giant cell tumors of bone. (8760006)	Fornasier V.L.... Mason L.	1996	SERPINA3
40	The expression of mRNA for insulin-like growth factors and their receptor in giant cell tumors of human bone. (8542699)	Middleton J.... Beresford J.	1996	IGF1R, IGF1
41	Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction. (7769107)	Gorn A.H.... Goldring S.R.	1995	CALCR, CALCA
42	Detection of mRNAs for urokinase-type plasminogen activator, its receptor, and type 1 inhibitor in giant cell tumors of bone with in situ hybridization. (7495280)	Zheng M.H.... Wood D.J.	1995	PLAUR
43	Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone. (8554927)	Teti A.... Pfeilschifter J.	1995	DYT10
44	Giant cell tumor of tendon sheath and pigmented villonodular synovitis: immunophenotype suggests a synovial cell origin. (7628850)	O'Connell J.X.... Rosenberg A.E.	1995	CD68
45	Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. (8202473)	Oursler M.J.... Spelsberg T.	1994	ACP5
46	Molecular analysis of transforming growth factor beta in giant cell tumor of bone. (8500096)	Butler M.G.... Schwartz H.S.	1993	TGFB2, BMP6
47	Characterization of a cell line derived from a human giant cell tumor that stimulates osteoclastic bone resorption. (8222432)	Oreffo R.O.... Bonewald L.F.	1993	IGF1
48	Osteoclast-like giant cell tumor of the pancreas: immunophenotypic similarity to giant cell tumor of bone. (1864595)	Goldberg R.D.... Montag A.G.	1991	PTPRC, ANPEP, CD4
49	Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type: evidence for a histogenetic relationship and mesenchymal differentiation. (2227926)	Lewandrowski K.B.... Compton C.C.	1990	VIM, SERPINA3
50	The osteoclast-type giant cell tumor of the pancreas. (2432851)	Berendt R.C.... Jewell L.D.	1987	SERPINA3

Genes related to giant cell tumor according to GeneCards:

(show top 50)    (show all 117)

id	Symbol	Description	Score	GeneCards Section Context
1	DES	desmin	11.0	Publications
2	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
3	S100B	S100 calcium binding protein B	11.0	Publications
4	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
5	ACP5	acid phosphatase 5, tartrate resistant	11.0	Publications
6	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	11.0	Publications
7	MYOG	myogenin (myogenic factor 4)	11.0	Publications
8	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
9	RGS12	regulator of G-protein signaling 12	11.0
10	COL6A3	collagen, type VI, alpha 3	11.0	Publications
11	CTSK	cathepsin K	11.0	Publications
12	ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	11.0
13	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
14	FGFR3	fibroblast growth factor receptor 3	11.0	Publications
15	FGF23	fibroblast growth factor 23	11.0
16	CTSL1	cathepsin L1	11.0
17	CLU	clusterin	11.0	Publications
18	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
19	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
20	CCNA2	cyclin A2	11.0	Publications
21	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
22	CALB2	calbindin 2	11.0	Publications
23	CA2	carbonic anhydrase II	11.0
24	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0
25	MUC1	mucin 1, cell surface associated	11.0	Publications
26	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
27	CTSB	cathepsin B	11.0
28	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
29	F13A1	coagulation factor XIII, A1 polypeptide	11.0
30	VIM	vimentin	11.0	Publications
31	ADAM12	ADAM metallopeptidase domain 12	11.0	Publications
32	MITF	microphthalmia-associated transcription factor	11.0	Publications
33	NF1	neurofibromin 1	11.0	Publications
34	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
35	PLAUR	plasminogen activator, urokinase receptor	11.0	Publications
36	TP53	tumor protein p53	11.0	Publications
37	SEBOX	SEBOX homeobox	11.0
38	SIGLEC15	sialic acid binding Ig-like lectin 15	11.0	Disorders
39	CD68	CD68 molecule	11.0	Publications
40	STK16	serine/threonine kinase 16	11.0	Publications
41	CLDN7	claudin 7	11.0	Publications
42	FGF3	fibroblast growth factor 3	11.0	Publications
43	TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	11.0	Publications
44	LYZ	lysozyme	11.0
45	SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	11.0
46	CKB	creatine kinase, brain	11.0	Publications
47	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0	Publications
48	CD33	CD33 molecule	11.0	Publications
49	TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	11.0	Publications
50	CD163	CD163 molecule	11.0	Publications

Pathways related to giant cell tumor according to GeneDecks:

(show top 50)    (show all 152)

id	Pathway	Score	Top Affiliating Genes
1	Glioblastoma Multiforme36	10.0	IGF1R, TSC2, CDKN1A, TP53, SRC, NF1
2	TRAIL Pathway36	9.8	TNFRSF10A, TNFSF11, TNFSF10, TNFRSF11B, TNFRSF11A, TNFRSF10C
3	Breast Cancer Regulation by Stathmin136	9.8	ROCK1, EGF, TEK, IGF1R, CCNB1, FGFR3
4	TNF Superfamily Pathway36	9.6	TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF11A, TNFRSF11B, TNFRSF8
5	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.3	TNFSF11, TNFRSF11B, TNFRSF11A, TNF, CALCA, CA2
6	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.3	TNF, TNFRSF11A, CA2, BGLAP, CALCA, TNFRSF11B
7	Signal transduction_AKT signaling41	9.0	CCND1, MYC, TSC1, TP53, IGF1R, CDKN1A
8	Hematopoietic cell lineage20	8.9	CD14, CSF1R, IL7, KIT, CSF1, IL1B
9	Osteoclast differentiation20	8.9	TNFRSF11A, TNF, CALCR, IL1B, MITF, TNFRSF11B
10	Melanoma20	8.8	CCND1, EGF, TP53, IGF1, IGF1R, MET
11	Bladder cancer20	8.8	TP53, CCND1, VEGFA, MMP9, CDKN1A, MYC
12	Paxillin Interactions36	8.7	SRC, IGF1, CSF1R, KIT, FGF2, TGFB2
13	ERK5 Signaling36	8.6	TGFB1, MET, FGFR3, FGF23, BMP6, MYC
14	eNOS Signaling36	8.6	BMP6, FGF23, FGFR3, MET, CCNA2, ESR1
15	MIF Regulation of Innate Immune Cells36	8.6	CD14, BMP6, IL1B, IL7, CCL2, TNF
16	Endothelin-1 Signaling Pathway36	8.5	IL1B, SRC, TEK, TNFSF11, TNFSF10, IGF1R
17	Rheumatoid arthritis20	8.5	VEGFA, ATP6V1A, IL1B, CCL2, TNF, TNFRSF11A
18	Akt Signaling36	8.5	CCND3, CCL2, IL7, MET, FGFR3, FGF23
19	Telomerase Components in Cell Signaling36	8.5	TERT, KIT, MYC, BMP6, FGF2, FGF23
20	P2Y Receptor Signaling36	8.3	CSF1R, FGF23, FGF3, EGF, TEK, IGF1R
21	JNK Pathway36	8.2	FGFR3, EGF, TGFB1, CSF1R, KIT, CD4
22	ILK Signaling36	8.2	IGF1, PTGS2, CSF1R, COL6A3, KIT, EGF
23	14-3-3 Induced Intracellular Signaling36	8.0	TNF, TSC2, FGF2, TGFB1, TSC1, SRC
24	Glucocorticoid Receptor Signaling36	7.9	CCL2, CD4, CEBPB, CDKN1A, IL1B, TGFB1
25	p53 Mediated Apoptosis36	7.9	FGF2, FGF23, FGFR3, MET, IGF1R, IGF1
26	Mitochondrial Apoptosis36	7.9	IGF1, KIT, BMP6, IGF1R, FGF2, FGF23
27	Nanog in Mammalian ESC Pluripotency36	7.7	EGF, CSF1R, BMP6, FGF2, TGFB2, TGFB1
28	Apoptotic Pathways in Synovial Fibroblasts36	7.5	FGF2, TP53, IGF1, EGF, TGFB1, IGF1R
29	GPCR Pathway36	7.5	IGF1, TGFB2, TGFB1, EGF, TEK, KIT
30	STAT3 Pathway36	7.4	IL1B, IL7, CCL2, TNF, TNFRSF10A, TNFRSF10B
31	MAPK signaling pathway20	7.4	EGF, FGF23, FGF2, TGFB2, TGFB1, NF1
32	Cellular Apoptosis Pathway36	7.4	TNF, TGFB2, TGFB1, TNFSF10, TNFRSF10A, EGF
33	NFAT in Immune Response36	7.4	FGF23, CD4, IGF1R, KIT, CSF1R, TGFB2
34	DHA Signaling36	7.3	MET, KIT, EGF, TGFB1, TGFB2, IGF1R
35	TGF-Beta Pathway36	7.3	BMP6, CD4, FGF2, FGF23, TGFB2, TGFB1
36	Cytokine-cytokine receptor interaction20	7.2	TNFRSF10C, TNFRSF10B, TNFRSF10A, TNF, CCL2, IL7
37	Pathways in cancer20	7.1	FGF23, CSF1R, BIRC5, MYC, VEGFA, TGFB1
38	PAK Pathway36	7.1	KIT, IL7, CCL2, IL1B, MET, FGFR3
39	Estrogen Pathway36	6.8	FGF23, FGF2, BMP6, TGFB1, FGFR3, MET
40	ERK Signaling36	6.7	FGFR3, FGF23, BMP6, MYC, KIT, TNFSF10
41	MAPK Family Pathway36	6.7	FGFR3, MET, BMP6, TNFSF10, IL7, CCL2
42	Colorectal Cancer Metastasis36	6.7	TGFB2, TP53, CCND1, MMP9, CDKN1A, BIRC5
43	Rho Family GTPases36	6.6	MET, IL1B, IL7, CCL2, IGF1R, IGF1
44	Molecular Mechanisms of Cancer36	6.5	MYC, TNFRSF8, TNFSF10, TNFSF11, TEK, CTNNB1
45	Tec Kinases Signaling36	6.4	CSF1R, IGF1R, CCL2, IL7, IL1B, MET
46	Pancreatic Adenocarcinoma36	6.3	CSF1R, CCNB1, MET, FGFR3, FGF23, FGF2
47	Antioxidant Action of Vitamin-C36	6.2	IL1B, MET, FGFR3, FGF23, FGF2, CD4
48	JAK-STAT Pathway36	6.1	KIT, MYC, TNFRSF10B, TNFRSF10C, TNFSF10, TEK
49	MAPK Signaling36	6.0	MET, FGFR3, COL6A3, SRC, TEK, TNF
50	p38 Signaling36	5.9	TEK, SRC, EGF, TGFB1, TGFB2, CSF1

Compounds related to giant cell tumor according to GeneDecks:

(show top 50)    (show all 393)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.0	KIT, MYOG, CKB, S100B, CCNA2, CASR
2	hematoxylin32	10.0	KIT, VIM, MUC1, S100B, CEACAM3, CD34
3	p00232	9.2	KIT, BIRC5, CD14, MMP13, MMP9, MET
4	hyaluronic acid32 18	10.1	VIM, MYC, BMP6, MUC1, MMP13, FGF2
5	pge232	9.0	CD14, CD4, MMP13, GSR, FGF2, IGF1R
6	ns 39832 42	9.8	BGLAP, FGF2, IL1B, TNF, TNFRSF11B, TNFSF11
7	glycogen32 18	9.8	KIT, VIM, MYC, MUC1, S100B, CEBPB
8	trastuzumab32 34 9 9	11.7	KIT, BIRC5, MUC1, ANXA5, CCND1, IGF1R
9	adpribose32	8.6	BIRC5, CDKN1A, ANXA5, CCNB1, CCNA2, CCND3
10	dihydrotestosterone32 9 18 9	11.6	VIM, BMP6, CLU, BGLAP, FGF2, IGF1R
11	estradiol32 9 18 9	11.6	SERPINA3, VIM, BIRC5, MUC1, CEBPB, MMP13
12	forskolin32 42 9 9	11.6	VIM, MYOG, BMP6, CKB, MUC1, S100B
13	procollagen32	8.5	VIM, BMP6, BGLAP, MMP13, MMP9, IGF1
14	nitric oxide32 9 18 9	11.4	KIT, MYOG, BMP6, BIRC5, MUC1, S100B
15	12-o-tetradecanoylphorbol 13-acetate32	8.3	MYC, MYOG, BMP6, UCHL1, CEBPB, CDKN1A
16	adenylate32	8.2	VIM, MYOG, S100B, CEBPB, MMP9, GSR
17	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	8.2	MYC, S100B, MMP9, MET, IL7, ANXA5
18	agar32	8.2	VIM, BIRC5, MUC1, CD34, FGF2, FGF3
19	celecoxib32 42 34 9 18 9	13.0	VEGFA, BIRC5, CDKN1A, MMP9, FGF2, IL1B
20	oxygen32 18	9.0	SERPINA3, MYOG, BIRC5, CLU, CKB, CEACAM3
21	cysteine32	8.0	SERPINA3, MYOG, CLU, BGLAP, MUC1, UCHL1
22	geldanamycin32 9 9	10.0	VEGFA, BIRC5, CDKN1A, MET, CCND1, IGF1R
23	calcitriol32 42 9 18 9	11.9	MYC, BMP6, CLU, BGLAP, CDKN1A, CD14
24	matrigel32	7.9	VIM, BSG, VEGFA, BMP6, CLU, MUC1
25	glutamate32	7.9	VIM, BSG, BMP6, CLU, CEBPB, CD4
26	imatinib32 34 9 9	10.8	KIT, VEGFA, MYC, BMP6, BIRC5, S100B
27	retinoid32	7.8	VIM, MYC, BMP6, CEBPB, CDKN1A, CD14
28	calcium32 9 18 9	10.8	KIT, SERPINA3, MYOG, BIRC5, BGLAP, MUC1
29	lactate32	7.6	KIT, VIM, BSG, BMP6, BIRC5, CLU
30	1,25 dihydroxy vitamin d332	7.6	MYC, BMP6, CLU, BGLAP, CD14, CD4
31	estrogen32	7.5	SERPINA3, BSG, MYOG, CLU, BGLAP, CKB
32	lipid32	7.5	SERPINA3, VIM, BSG, MYOG, BIRC5, CLU
33	glutamine32	7.3	KIT, VIM, BMP6, CKB, S100B, CD14
34	sb 20358032 42	8.1	VIM, BSG, VEGFA, BMP6, BIRC5, BGLAP
35	docetaxel32 34 9 9	10.0	KIT, VEGFA, MYC, BIRC5, CLU, CDKN1A
36	adriamycin32	6.9	VIM, MYC, BIRC5, MUC1, CEACAM3, CDKN1A
37	15-deoxy-delta-12,14-prostaglandin j232	6.8	VEGFA, MYC, BMP6, BIRC5, CDKN1A, FGF2
38	arsenite32 18	7.8	VEGFA, MYC, BIRC5, CDKN1A, MMP9, GSR
39	wortmannin32 42	7.7	VIM, BIRC5, S100B, CDKN1A, CD14, MMP9
40	vitamin d32	6.7	VIM, BMP6, CLU, BGLAP, CKB, CEBPB
41	butyrate32	5.8	VIM, MYC, MYOG, BMP6, BIRC5, CLU
42	curcumin32	5.5	VEGFA, MYC, BIRC5, CDKN1A, MMP13, MMP9
43	tamoxifen32 34 9 9	8.2	VIM, VEGFA, MYC, BMP6, BIRC5, CLU
44	paraffin32	4.7	KIT, SERPINA3, VIM, VEGFA, MYC, MYOG
45	cisplatin32 34 9 9	7.5	VEGFA, MYC, BMP6, BIRC5, CLU, BGLAP
46	retinoic acid32 42 18	5.9	KIT, MYC, MYOG, BMP6, BIRC5, CLU
47	thymidine32 18	4.9	KIT, MYC, BMP6, BIRC5, CLU, MUC1
48	actinomycin d32	3.6	KIT, VIM, VEGFA, MYC, BIRC5, CLU
49	pd 98,05932	3.2	KIT, MYC, MYOG, BMP6, BIRC5, CEBPB
50	genistein32 9 18 9	6.1	VIM, VEGFA, MYC, BIRC5, CEBPB, CDKN1A

Cellular components related to giant cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endolysosome lumen	GO:036021	10.4	CTSL1, CTSB, CTSK
2	cyclin-dependent protein kinase holoenzyme complex	GO:000307	9.9	CDKN1A, CCND3, CCND1
3	external side of plasma membrane	GO:009897	9.3	CTSB, PTPRC, TNFRSF11A, TNF, ANPEP, ANXA5
4	integral to plasma membrane	GO:005887	8.7	TNFRSF10C, TNFSF10, TNFSF11, TEK, PTPRC, PLAUR
5	axon	GO:030424	8.6	TGFB2, TGFB1, NF1, CA2, UCHL1, MYC
6	platelet alpha granule lumen	GO:031093	8.5	TGFB2, TGFB1, EGF, F13A1, IGF1, CLU
7	extracellular region	GO:005576	6.4	ADAM12, LYZ, CST3, SERPINA3, CCL2, IL7
8	extracellular space	GO:005615	5.9	LYZ, CCL2, IL7, IL1B, MET, FGF23
9	cytoplasm	GO:005737	5.4	PTPRE, PTGS2, TERT, TEK, TNFSF11, TNFRSF8

Biological processes related to giant cell tumor according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	ossification	GO:001503	10.6	TWIST1, TNFSF11, TNFRSF11A, CASR, MYOG, RUNX2
2	regulation of bone resorption	GO:045124	10.5	BGLAP, CSF1R, NF1, SRC
3	monocyte chemotaxis	GO:002548	10.4	CALCA, TNFSF11, TNFRSF11A, CCL2
4	bone resorption	GO:045453	10.3	PTH, TNFSF11, IL7, SRC, CTSK, CTNNB1
5	insulin receptor signaling pathway	GO:008286	10.1	FGF23, FGF2, FGF3, FGFR3, IGF1R, TSC1
6	osteoclast differentiation	GO:030316	10.1	TNF, TNFRSF11A, TNFSF11, CTNNB1, CSF1R, CSF1
7	macrophage differentiation	GO:030225	10.0	VEGFA, MMP9, CSF1, CSF1R
8	skeletal system development	GO:001501	10.0	IGF1, BMP6, BGLAP, MMP9, FGFR3, TP63
9	mammary gland alveolus development	GO:060749	9.9	TNFRSF11A, TNFSF11, EGF, CCND1
10	positive regulation of endothelial cell proliferation	GO:001938	9.8	VEGFA, NF1, FGF2, CCL2, BMP6, TEK
11	peptidyl-tyrosine phosphorylation	GO:018108	9.7	FGFR3, KIT, CSF1R, EGF, SRC, TEK
12	embryo implantation	GO:007566	9.7	PTGS2, CALCA, IL1B, MMP9, BSG
13	response to radiation	GO:009314	9.7	TNFSF11, TGFB1, ZAK, MMP9, KIT, TGFB2
14	positive regulation of angiogenesis	GO:045766	9.7	CD34, FGF2, IL1B, TEK, TWIST1, MMP9
15	Ras protein signal transduction	GO:007265	9.7	CDKN1A, NF1, SRC, FGF2, CCNA2, IGF1
16	positive regulation of osteoclast differentiation	GO:045672	9.7	CA2, CSF1, TNFSF11, TNF
17	positive regulation of cerebellar granule cell precursor proliferation	GO:021940	9.6	FGF2, IGF1, EGF
18	cell-cell signaling	GO:007267	9.5	PGR, TGFB2, PTH, TEK, ESR2, TNFRSF11A
19	response to gamma radiation	GO:010332	9.5	CCL2, MYC, IL1B, PTPRC, TP53
20	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.5	TGFB1, TEK, FGF2, FGFR3, KIT
21	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.5	FGF2, CSF1R, TEK, TNF, IL1B, FGF23
22	negative regulation of gene expression	GO:010629	9.4	CDKN1A, PGR, PLAUR, CD34, ESR1, TNF
23	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.2	TNF, IL1B, ESR1, KIT, TNFSF11, TNFRSF11A
24	activation of MAPK activity	GO:000187	9.1	PTPRC, TNF, IL1B, GRM4, MET, FGF2
25	positive regulation of gene expression	GO:010628	9.1	KIT, CSF1, TGFB2, TGFB1, TWIST1, VEGFA
26	response to organic nitrogen	GO:010243	9.1	PTGS2, CCND1, IL1B, CDKN1A, TGFB2
27	response to vitamin D	GO:033280	9.0	TGFB2, BGLAP, IL1B, PTGS2, TGFB1
28	positive regulation of cell division	GO:051781	8.9	FGF3, IL1B, FGF2, VEGFA, TGFB1, TGFB2
29	cell cycle arrest	GO:007050	8.8	TSC1, TGFB1, TGFB2, TSC2, CDKN1A, TP53
30	positive regulation of mitosis	GO:045840	8.8	IL1B, IGF1, TNF, EGF, MET
31	protein kinase B signaling cascade	GO:043491	8.8	CCL2, TNF, TGFB1, TSC2, IL1B
32	platelet degranulation	GO:002576	8.7	TGFB1, F13A1, IGF1, CLU, VEGFA, TGFB2
33	apoptotic process	GO:006915	8.7	TP53, IL1B, FGF2, CD14, BIRC5, VIM
34	positive regulation of apoptotic process	GO:043065	8.7	ESR2, PTGS2, CLU, ZAK, TGFB2, NF1
35	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	CLU, TNF, TNFRSF11A, TNFRSF8, TNFSF11, TGFB1
36	negative regulation of apoptotic process	GO:043066	8.6	PLAUR, IL7, MYC, TGFB2, CDKN1A, VEGFA
37	cellular response to organic cyclic compound	GO:071407	8.6	TGFB1, IL1B, CCL2, TNF, CTNNB1
38	response to estradiol stimulus	GO:032355	8.5	MMP9, TGFB2, PTGS2, ESR1, IL1B, CTNNB1
39	anti-apoptosis	GO:006916	8.5	BIRC5, TNF, TEK, IGF1, IGF1R, CCL2
40	positive regulation of MAP kinase activity	GO:043406	8.4	TNF, VEGFA, TGFB1, EGF, TNFSF11
41	MAPK cascade	GO:000165	8.3	NF1, IL1B, CCL2, MYC, FGFR3, TGFB1
42	positive regulation of protein phosphorylation	GO:001934	8.2	TGFB1, VEGFA, IL1B, CCND3, CCND1, TNF
43	blood coagulation	GO:007596	8.1	SRC, TEK, TP53, F13A1, IGF1, ANXA5
44	inflammatory response	GO:006954	7.8	CSF1, BMP6, CEBPB, CD14, IL1B, CCL2
45	response to drug	GO:042493	7.3	CCL2, CCND1, TNF, TNFRSF11B, PTGS2, TGFB2
46	negative regulation of cell proliferation	GO:008285	7.3	PTGS2, TGFB2, TGFB1, TP53, TSC2, FGF2
47	positive regulation of cell proliferation	GO:008284	7.2	MYC, FGF2, KIT, FGF3, IL7, FGFR3
48	positive regulation of transcription, DNA-dependent	GO:045893	6.9	RUNX2, CCNA2, TP63, IGF1, IL1B, TGFB1
49	signal transduction	GO:007165	6.6	KIT, TNFRSF10C, TNFRSF11A, TNFRSF11B, TNFRSF8, TNFSF10
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.6	BMP6, MYC, TNF, TNFSF11, PTH, CTNNB1

Molecular functions related to giant cell tumor according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	TRAIL binding	GO:045569	10.2	TNFRSF10C, TNFRSF10B, TNFRSF10A
2	receptor activity	GO:004872	9.9	PLAUR, CD33, CD4, ANPEP, AMFR, CALCR
3	protein tyrosine kinase activity	GO:004713	9.5	TEK, IGF1R, MET, FGFR3, KIT, SRC
4	protein kinase binding	GO:019901	9.4	PTPRC, TPX2, TP53, CCND1, CCND3, CCNA2
5	cytokine activity	GO:005125	8.6	CSF1, TGFB2, TNFSF11, TNFSF10, TNFRSF11B, TNF
6	protein heterodimerization activity	GO:046982	8.0	TGFB2, TGFB1, TWIST1, TP53, MET, CEBPB
7	enzyme binding	GO:019899	7.7	ESR2, ESR1, CCND1, CD4, TP53, PTGS2
8	growth factor activity	GO:008083	7.7	CSF1, TGFB2, TGFB1, EGF, IGF1, IL7
9	protein homodimerization activity	GO:042803	7.4	PTPRE, TWIST1, TSC2, TGFB1, TGFB2, CSF1
10	protein binding	GO:005515	2.0	ADAM12, CTSL1, CTSB, CTNNB1, SRC, PTPRC