MCID: GNT020
MIFTS: 23

Giant Congenital Nevus malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Giant Congenital Nevus

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Aliases & Descriptions for Giant Congenital Nevus:

Name: Giant Congenital Nevus 46
Giant Congenital Melanocytic Nevus 46 24 25
Giant Pigmented Hairy Nevus 46 24 66
Gphn 46 24
Congenital Giant Pigmented Nevus of Skin 24
Congenital Melanocytic Nevus Syndrome 24
Large Congenital Melanocytic Nevus 46
Giant Congenital Melanocytic Nevi 24
 
Giant Congenital Pigmented Nevus 24
Congenital Giant Pigmented Nevus 46
Congenital Hairy Nevus 46
Giant Pigmented Nevus 46
Bathing Trunk Nevus 46
Giant Hairy Nevus 46
Gmn 24

Classifications:



Summaries for Giant Congenital Nevus

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Genetics Home Reference:24 Giant congenital melanocytic nevus is a skin condition characterized by an abnormally dark, noncancerous skin patch (nevus) that is composed of pigment-producing cells called melanocytes. It is present from birth (congenital) or is noticeable soon after birth. The nevus may be small in infants, but it will usually grow at the same rate the body grows and will eventually be at least 40 cm (15.75 inches) across. The nevus can appear anywhere on the body, but it is more often found on the trunk or limbs. The color ranges from tan to black and can become darker or lighter over time. The surface of a nevus can be flat, rough, raised, thickened, or bumpy; the surface can vary in different regions of the nevus, and it can change over time. The skin of the nevus is often dry and prone to irritation and itching (dermatitis). Excessive hair growth (hypertrichosis) can occur within the nevus. There is often less fat tissue under the skin of the nevus; the skin may appear thinner there than over other areas of the body.

MalaCards based summary: Giant Congenital Nevus, also known as giant congenital melanocytic nevus, is related to gphn-related hyperekplexia and molybdenum cofactor deficiency. Affiliated tissues include skin, spinal cord and brain.

NIH Rare Diseases:46 A giant congenital nevus is a dark-colored, often hairy patch of skin that is present at birth (congenital). it grows proportionally to the child. a congenital pigmented nevus is considered giant if by adulthood it is larger than 20cm (about 8 inches) in diameter. giant congenital nevi can occur in people of any racial or ethnic background and on any area of the body. they result from localized genetic changes in the fetus that lead to excessive growth of melanocytes, the cells in the skin that are responsible for skin color. people with giant congenital nevi may experience a number of complications ranging from fragile, dry, or itchy skin to neurological problems like neurocutaneous melanocytosis (excess pigment cells in the brain or spinal cord). they also have an increased risk of developing malignant melanoma, a type of skin cancer. last updated: 5/7/2015

Wikipedia:69 The congenital melanocytic nevus is a type of melanocytic nevus (or mole) found in infants at birth.... more...

Related Diseases for Giant Congenital Nevus

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Graphical network of the top 20 diseases related to Giant Congenital Nevus:



Diseases related to giant congenital nevus

Symptoms for Giant Congenital Nevus

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Drugs & Therapeutics for Giant Congenital Nevus

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Autologous Engineered Skin Substitutes for Closure of Skin WoundsTerminatedNCT00591513Phase 2, Phase 3
2Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin DefectsRecruitingNCT02145130Phase 1
3Natural History Study of Moles and Suspicious MelanomaCompletedNCT00288938
4Molecular Analysis of Childhood and Adolescent Melanocytic LesionsRecruitingNCT02775643

Search NIH Clinical Center for Giant Congenital Nevus

Genetic Tests for Giant Congenital Nevus

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Genetic tests related to Giant Congenital Nevus:

id Genetic test Affiliating Genes
1 Congenital Giant Melanocytic Nevus25

Anatomical Context for Giant Congenital Nevus

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MalaCards organs/tissues related to Giant Congenital Nevus:

34
Skin, Spinal cord, Brain, Thyroid

Animal Models for Giant Congenital Nevus or affiliated genes

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Publications for Giant Congenital Nevus

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Articles related to Giant Congenital Nevus:

(show all 20)
idTitleAuthorsYear
1
Giant congenital nevus associated with papillary thyroid cancer: the first case report. (23968452)
2013
2
A rare association of congenital lumbar hernia and giant congenital nevus. (22648191)
2013
3
Impressive pseudotumoral proliferative nodules in a giant congenital nevus of a newborn. (22958141)
2013
4
Giant congenital nevus with plexiform neurofibroma and malignant peripheral nerve sheath tumor. (22413842)
2012
5
Wells on natural selection: right for the wrong reason--described a giant congenital nevus. (22256630)
2011
6
Images in clinical medicine. Giant congenital nevus. (19726769)
2009
7
Treatment of giant congenital nevus of the back by convergent serial excision. (18837711)
2008
8
Desmoplastic giant congenital nevus with progressive depigmentation. (17097364)
2007
9
A giant congenital nevus spilus in an 8-year-old girl. (17142204)
2006
10
Cutaneous ganglioneuroma within a giant congenital nevus. (24223002)
2005
11
Giant congenital nevus with progressive sclerodermoid reaction in a newborn. (11576407)
2001
12
A newborn with nodular ulcerated lesion on a giant congenital nevus. (10990581)
2000
13
Poliosis associated with a giant congenital nevus. (10411174)
1999
14
Giant congenital nevus. (10829894)
1995
15
Very late metastasis (27 years) of cutaneous malignant melanoma arising in a halo giant congenital nevus. (8075446)
1994
16
Chromosomal findings in cultured melanocytes from a giant congenital nevus. (8330286)
1993
17
Giant congenital nevus and chronic progressive ascending hemiparesis (Mills syndrome). Report of a case. (1624284)
1992
18
Giant congenital nevus and malignant melanoma. (2715664)
1989
19
Giant congenital nevus and melanoma. (3716969)
1986
20
Giant congenital nevus as a basis for the development of malignant melanoma. (4036470)
1985

Variations for Giant Congenital Nevus

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Expression for genes affiliated with Giant Congenital Nevus

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Search GEO for disease gene expression data for Giant Congenital Nevus.

Pathways for genes affiliated with Giant Congenital Nevus

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GO Terms for genes affiliated with Giant Congenital Nevus

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Sources for Giant Congenital Nevus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet