MCID: GNT020
MIFTS: 18

Giant Congenital Nevus malady

Summaries for Giant Congenital Nevus

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 A congenital giant nevus is a dark-colored, often hairy patch of skin that is present at birth. it is usually smaller in infants and children, but continues to grow with the child. a giant pigmented nevus is usually larger than 20cm in diameter once it stops growing. they are often found on the buttocks, which is known as "bathing trunk" nevi. skin cancer (such as malignant melanoma and other types) may develop in up to 15% (1 out of 6) of people with larger or giant nevi, often in childhood. the risk is higher for larger or giant congenital nevi located on the back or abdomen. last updated: 6/23/2011

MalaCards: Giant Congenital Nevus, also known as giant pigmented hairy nevus, is related to large congenital melanocytic nevus and gphn-related hyperekplexia. Affiliated tissues include skin and thyroid.

Aliases & Classifications for Giant Congenital Nevus

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

giant congenital nevus 43
giant pigmented hairy nevus 43 61
congenital giant pigmented nevus 43
congenital hairy nevus 43
giant pigmented nevus 61
bathing trunk nevus 43
giant hairy nevus 43


Related Diseases for Giant Congenital Nevus

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Giant Congenital Nevus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1large congenital melanocytic nevus10.6
2gphn-related hyperekplexia10.3
3epidermal nevus, somatic10.3
4arteriovenous malformation10.3
5hypercalcemia10.3
6angiolipoma10.3
7intracranial arteriovenous malformation10.3
8diastematomyelia10.2
9epidermal nevus10.2
10choristoma10.2
11plexiform neurofibroma10.1
12cutaneous ganglioneuroma10.1
13ganglioneuroma10.1
14cutaneous malignant melanoma10.1
15mills syndrome10.1

Graphical network of diseases related to Giant Congenital Nevus:



Diseases related to giant congenital nevus

Clinical Features for Giant Congenital Nevus

Drugs & Therapeutics for Giant Congenital Nevus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Giant Congenital Nevus

Genetic Tests for Giant Congenital Nevus

Anatomical Context for Giant Congenital Nevus

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33MalaCards
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MalaCards organs/tissues related to Giant Congenital Nevus:

33
Skin, Thyroid

Animal Models for Giant Congenital Nevus or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Giant Congenital Nevus

Sources:
51PubMed
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Articles related to Giant Congenital Nevus:

(show all 41)
idTitleAuthorsYear
1
Malignant melanoma arising at the site of a previously excised giant congenital melanocytic nevus. (24284966)
2014
2
Giant congenital nevus associated with papillary thyroid cancer: the first case report. (23968452)
2013
3
Impressive pseudotumoral proliferative nodules in a giant congenital nevus of a newborn. (22958141)
2013
4
A rare association of congenital lumbar hernia and giant congenital nevus. (22648191)
2013
5
A Giant Congenital Melanocytic Nevus Associated with Neurocutaneous Melanosis. (24173435)
2013
6
Alveolar rhabdomyosarcoma arising in a giant congenital melanocytic nevus in an adult--case report with review of literature. (23451914)
2013
7
Association of giant congenital melanocytic nevus, halo nevus and vitiligo in a 75-year-old patient. (22570035)
2012
8
Giant congenital melanocytic nevus with choroid plexus papilloma: case report and review of literature. (21344363)
2012
9
Giant congenital nevus with plexiform neurofibroma and malignant peripheral nerve sheath tumor. (22413842)
2012
10
Wells on natural selection: right for the wrong reason--described a giant congenital nevus. (22256630)
2011
11
Intraocular choristoma, anterior staphyloma with ipsilateral nevus sebaceus, and congenital giant hairy nevus: a case report. (21416777)
2011
12
Images in clinical medicine. Giant congenital nevus. (19726769)
2009
13
Giant congenital melanocytic nevus (bathing trunk nevus) associated with lipoma and neurofibroma: report of two cases. (19736430)
2009
14
SCALP syndrome: sebaceous nevus syndrome, CNS malformations, aplasia cutis congenita, limbal dermoid, and pigmented nevus (giant congenital melanocytic nevus) with neurocutaneous melanosis: a distinct syndromic entity. (18234391)
2008
15
Treatment of giant congenital nevus of the back by convergent serial excision. (18837711)
2008
16
E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro. (18502615)
2008
17
Neurocutaneous melanosis in a newborn with giant congenital melanocytic nevus. (17727949)
2007
18
Desmoplastic giant congenital nevus with progressive depigmentation. (17097364)
2007
19
Giant congenital melanocytic nevus with neurofibroma-like changes and spina bifida occulta. (17076723)
2006
20
A giant congenital nevus spilus in an 8-year-old girl. (17142204)
2006
21
Cutaneous ganglioneuroma within a giant congenital nevus. (24223002)
2005
22
Congenital giant melanocytic nevus with pigmented epithelioid cells: a variant of epithelioid blue nevus. (11803278)
2002
23
Giant congenital nevus with progressive sclerodermoid reaction in a newborn. (11576407)
2001
24
Giant congenital melanocytic nevus with cutis verticis gyrata. (11359987)
2001
25
A newborn with nodular ulcerated lesion on a giant congenital nevus. (10990581)
2000
26
Adnexal-centered giant congenital melanocyte nevus with extensive ganglioneuromatous component and trisomy 7. (10441625)
1999
27
Poliosis associated with a giant congenital nevus. (10411174)
1999
28
Hypercalcemia in a patient with malignant melanoma arising in congenital giant pigmented nevus. A case of increased serum level of parathyroid hormone-related protein. (9693191)
1998
29
Giant congenital nevocellular nevus overlying an encephalocele. (9133851)
1996
30
Giant congenital nevus. (10829894)
1995
31
Diastematomyelia: a congenital anomaly not to be confused with a giant hairy nevus. (7604100)
1995
32
Very late metastasis (27 years) of cutaneous malignant melanoma arising in a halo giant congenital nevus. (8075446)
1994
33
Congenital giant pigmented nevus associated with angiolipoma. (8349929)
1993
34
Chromosomal findings in cultured melanocytes from a giant congenital nevus. (8330286)
1993
35
Giant congenital nevus and chronic progressive ascending hemiparesis (Mills syndrome). Report of a case. (1624284)
1992
36
Congenital choroid plexus papilloma and giant nevomelanocytic nevus: report of a case. (2347972)
1990
37
Giant congenital nevus and malignant melanoma. (2715664)
1989
38
Congenital giant pigmented nevus and intracranial arteriovenous malformation. (2711318)
1989
39
Rhabdomyosarcoma arising in a congenital giant nevus associated with neurocutaneous melanosis in a neonate. (3430311)
1987
40
Giant congenital nevus and melanoma. (3716969)
1986
41
Giant congenital nevus as a basis for the development of malignant melanoma. (4036470)
1985

Genetic Variations for Giant Congenital Nevus

Expression for genes affiliated with Giant Congenital Nevus

Sources:
15Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Giant Congenital Nevus.

Pathways for genes affiliated with Giant Congenital Nevus

Compounds for genes affiliated with Giant Congenital Nevus

GO Terms for genes affiliated with Giant Congenital Nevus

Products for genes affiliated with Giant Congenital Nevus

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Sources for Giant Congenital Nevus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet