GPC
MCID: GNT006
MIFTS: 38

Giant Papillary Conjunctivitis (GPC) malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Giant Papillary Conjunctivitis

Aliases & Descriptions for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 12 50 14
Conjunctivitis, Giant Papillary 69
Conjunctivitis Giant Papillary 52
Gpc 50

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:2457
MeSH 42 D003233
NCIt 47 C34507
SNOMED-CT 64 231857004
UMLS 69 C0009769

Summaries for Giant Papillary Conjunctivitis

MalaCards based summary : Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to papillary conjunctivitis and conjunctivitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and neutrophil.

Related Diseases for Giant Papillary Conjunctivitis

Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
id Related Disease Score Top Affiliating Genes
1 papillary conjunctivitis 10.7
2 conjunctivitis 10.7
3 anterior dislocation of lens 10.2 CCL11 IL4
4 thelaziasis 10.2 CCL11 IL4
5 lymphoblastic leukemia 10.2 CCL11 IL4
6 isthmus cancer 10.2 CCL11 IL4
7 cerebral primitive neuroectodermal tumor 10.2 CCL11 IL4
8 apricot allergy 10.2 CCL11 IL4
9 trachea leiomyoma 10.2 CCL11 IL4
10 visceral steatosis 10.2 CCL11 IL4
11 cutaneous fibrous histiocytoma 10.2 CCL11 IL4
12 lymphocytic gastritis 10.2 CCL11 IL4
13 intravascular angioleiomyoma 10.2 CCL11 IL4
14 latent syphilis 10.2 CCL11 IL6
15 ethmoid sinusitis 10.2 CCL11 IL4
16 inflamed seborrheic keratosis 10.2 CCL11 IL4
17 clostridium difficile colitis 10.2 IL4 IL6
18 barbiturate abuse 10.2 CCL11 IL4
19 childhood malignant mesenchymoma 10.2 CCL11 IL6
20 microglandular adenosis of breast 10.2 CCL11 CXCL8
21 hidradenitis suppurativa 10.2 CCL11 CXCL8
22 gonococcal endophthalmia 10.1 IL4 IL6
23 ectodermal dysplasia bartalos type 10.1 IL4 IL6
24 parkinson disease 11 10.1 CCL11 CXCL8
25 immune-complex glomerulonephritis 10.1 IL4 IL6
26 coenurosis 10.1 IL4 IL6
27 conidiobolomycosis 10.1 CXCL8 IL4
28 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL6 LTF
29 red cell phospholipid defect with hemolysis 10.1 IL4 IL6
30 chancroid 10.1 CXCL8 IL4
31 breast intracanalicular fibroadenoma 10.1 CXCL8 IL4
32 orbital osteomyelitis 10.1 IL4 IL6
33 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 IL6 LTF
34 tuberculosis 10.1 IL4 IL6
35 oculomotor nerve paralysis 10.1 CXCL8 IL6
36 common peroneal nerve lesion 10.1 CXCL8 IL6
37 coronary arterial fistulas 10.1 CXCL8 LTF
38 neonatal hypoxic and ischemic brain injury 10.1 CXCL8 IL6
39 thymic neuroendocrine carcinoma 10.1 CXCL8 IL6
40 scleroderma, familial progressive 10.1 CXCL8 LTF
41 schwannoma of ureter 10.1 CXCL8 IL6
42 vernal conjunctivitis 10.1
43 childhood electroclinical syndrome 10.1 CXCL8 IL6
44 handl syndrome 10.1 CXCL8 LTF
45 labyrinthine bilateral reactive loss 10.1 CXCL8 IL6
46 esophagus lymphoma 10.1 CXCL8 IL6
47 larynx carcinoma in situ 10.1 CXCL8 IL6
48 bullous retinoschisis 10.1 CXCL8 IL6
49 carbuncle 10.1 CXCL8 IL6
50 stomatitis 10.1 CXCL8 IL6

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to Giant Papillary Conjunctivitis

Symptoms & Phenotypes for Giant Papillary Conjunctivitis

Drugs & Therapeutics for Giant Papillary Conjunctivitis

Drugs for Giant Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Anti-Allergic Agents Phase 4
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4
9 Gastrointestinal Agents Phase 4
10 glucocorticoids Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Methylprednisolone acetate Phase 4
15 Methylprednisolone Hemisuccinate Phase 4
16 Neuroprotective Agents Phase 4
17 Peripheral Nervous System Agents Phase 4
18 Prednisolone acetate Phase 4
19 Prednisolone hemisuccinate Phase 4
20 Prednisolone phosphate Phase 4
21 Protective Agents Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Active, not recruiting NCT01437982 Phase 4

Search NIH Clinical Center for Giant Papillary Conjunctivitis

Genetic Tests for Giant Papillary Conjunctivitis

Anatomical Context for Giant Papillary Conjunctivitis

MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

39
Eye, Neutrophil

Publications for Giant Papillary Conjunctivitis

Articles related to Giant Papillary Conjunctivitis:

(show top 50) (show all 99)
id Title Authors Year
1
Filtering bleb-induced giant papillary conjunctivitis. ( 17826299 )
2008
2
Giant papillary conjunctivitis. ( 18769199 )
2008
3
Giant papillary conjunctivitis. ( 18282547 )
2008
4
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. ( 18216583 )
2008
5
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. ( 17760635 )
2007
6
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. ( 17557145 )
2007
7
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. ( 16767372 )
2006
8
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. ( 15677951 )
2005
9
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 14566648 )
2003
10
Contact lens chemistry and giant papillary conjunctivitis. ( 12772728 )
2003
11
Giant papillary conjunctivitis associated with an ocular prosthesis. ( 12366372 )
2001
12
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. ( 15326900 )
2000
13
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study ( 10844086 )
2000
14
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. ( 10444049 )
1999
15
Giant papillary conjunctivitis--a review. ( 10337425 )
1999
16
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. ( 10410873 )
1999
17
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. ( 10703125 )
1999
18
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 9785608 )
1998
19
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. ( 9001768 )
1997
20
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. ( 9124242 )
1997
21
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. ( 8755197 )
1996
22
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. ( 7586473 )
1995
23
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. ( 22827277 )
1995
24
Localised giant papillary conjunctivitis secondary to a dermolipoma. ( 7556754 )
1995
25
Contact lens type, material, and deposits and giant papillary conjunctivitis. ( 7712614 )
1995
26
Giant papillary conjunctivitis. ( 7886881 )
1994
27
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. ( 7995075 )
1994
28
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). ( 7910133 )
1993
29
Meibomian gland function and giant papillary conjunctivitis. ( 8420368 )
1993
30
Causative factors in unilateral giant papillary conjunctivitis. ( 8495560 )
1993
31
Unusual causes of giant papillary conjunctivitis. ( 8458237 )
1993
32
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. ( 8319490 )
1993
33
Meibomian gland function and giant papillary conjunctivitis. ( 8420369 )
1993
34
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. ( 8470716 )
1993
35
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. ( 1499118 )
1992
36
Treatment of giant papillary conjunctivitis with cromolyn sodium. ( 1559288 )
1992
37
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. ( 1499122 )
1992
38
Daily enzyme cleaning for giant papillary conjunctivitis. ( 1498575 )
1992
39
Meibomian gland function and giant papillary conjunctivitis. ( 1642294 )
1992
40
Continued contact lens wear in patients with giant papillary conjunctivitis. ( 1904798 )
1991
41
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. ( 1846131 )
1991
42
Eosinophil granule major basic protein in contact lenses of patients with giant papillary conjunctivitis. ( 2199092 )
1990
43
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. ( 2407379 )
1990
44
Giant papillary conjunctivitis. ( 2193971 )
1990
45
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. ( 2196302 )
1990
46
Some unusual nonallergic causes of giant papillary conjunctivitis. ( 2095029 )
1990
47
Association of giant papillary conjunctivitis with seasonal allergies. ( 2320363 )
1990
48
Giant papillary conjunctivitis associated with elevated corneal deposits. ( 1706653 )
1990
49
Contact lens induced giant papillary conjunctivitis: a retrospective study. ( 2708768 )
1989
50
HPLC analysis of tear proteins in giant papillary conjunctivitis. ( 2625085 )
1989

Variations for Giant Papillary Conjunctivitis

Expression for Giant Papillary Conjunctivitis

Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.

Pathways for Giant Papillary Conjunctivitis

Pathways related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CCL11 CXCL8 IL4 IL6 IL7 LTF
2
Show member pathways
13.35 CCL11 CXCL8 IL4 IL6 IL7
3
Show member pathways
13.23 CCL11 CXCL8 IL4 IL6 IL7
4
Show member pathways
13.11 CCL11 CXCL8 IL4 IL6 IL7
5
Show member pathways
13.04 CCL11 CXCL8 IL4 IL6 IL7
6
Show member pathways
12.96 CCL11 CXCL8 IL4 IL6 IL7
7
Show member pathways
12.59 CCL11 CXCL8 IL4 IL6
8 12.34 IL4 IL6 IL7
9
Show member pathways
12.04 CCL11 CXCL8 IL4 IL6
10
Show member pathways
12 IL4 IL6 IL7
11
Show member pathways
11.94 CXCL8 IL4 IL6
12 11.78 CXCL8 IL4 IL6
13
Show member pathways
11.78 CCL11 CXCL8 IL4 IL6
14 11.75 IL4 IL6 IL7
15 11.64 IL4 IL6 IL7
16 11.55 CXCL8 IL4 IL6
17 11.51 IL4 IL6
18 11.51 CCL11 CXCL8 IL4 IL6
19 11.47 CXCL8 IL6
20 11.45 CCL11 IL4
21
Show member pathways
11.45 CXCL8 IL6
22 11.39 CXCL8 IL6
23 11.38 CXCL8 IL6
24 11.35 CXCL8 IL6
25 11.32 CXCL8 IL6
26 11.3 CXCL8 IL4 IL6
27 11.29 CCL11 IL4
28 11.15 CXCL8 IL6
29 11.06 CCL11 CXCL8 IL4 IL6
30 11.05 IL4 IL6 IL7
31 10.97 IL4 IL6 IL7
32 10.87 CXCL8 IL6
33 10.75 IL4 IL6
34 10.25 CCL11 CXCL8 IL4 IL6 IL7

GO Terms for Giant Papillary Conjunctivitis

Cellular components related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CXCL8 IL4 IL6 IL7 LTF
2 extracellular space GO:0005615 9.1 CCL11 CXCL8 IL4 IL6 IL7 LTF

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.72 CCL11 CXCL8 IL6
2 negative regulation of apoptotic process GO:0043066 9.62 IL4 IL6 IL7 LTF
3 chemokine-mediated signaling pathway GO:0070098 9.6 CCL11 CXCL8
4 positive regulation of B cell activation GO:0050871 9.59 IL4 IL6
5 neutrophil chemotaxis GO:0030593 9.58 CCL11 CXCL8
6 positive regulation of T cell proliferation GO:0042102 9.58 IL4 IL6
7 response to cytokine GO:0034097 9.57 IL4 IL6
8 positive regulation of osteoblast differentiation GO:0045669 9.56 IL6 LTF
9 defense response to Gram-negative bacterium GO:0050829 9.54 IL6 LTF
10 chemotaxis GO:0006935 9.54 CCL11 CXCL8 IL4
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IL4 IL6
12 monocyte chemotaxis GO:0002548 9.51 CCL11 IL6
13 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.49 IL4 IL7
14 positive regulation of B cell proliferation GO:0030890 9.48 IL4 IL7
15 innate immune response in mucosa GO:0002227 9.46 IL4 LTF
16 defense response to protozoan GO:0042832 9.43 IL4 IL6
17 cellular response to tumor necrosis factor GO:0071356 9.43 CCL11 CXCL8 IL6
18 positive regulation of T cell differentiation GO:0045582 9.4 IL4 IL7
19 cellular response to interleukin-1 GO:0071347 9.33 CCL11 CXCL8 IL6
20 humoral immune response GO:0006959 9.13 IL6 IL7 LTF
21 immune response GO:0006955 9.02 CCL11 CXCL8 IL4 IL6 IL7

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL11 CXCL8
2 cytokine receptor binding GO:0005126 9.16 IL4 IL7
3 growth factor activity GO:0008083 9.13 IL4 IL6 IL7
4 cytokine activity GO:0005125 9.02 CCL11 CXCL8 IL4 IL6 IL7

Sources for Giant Papillary Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
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68 Tocris
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70 UMLS via Orphanet
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