GPC
MCID: GNT006
MIFTS: 37

Giant Papillary Conjunctivitis (GPC) malady

Summaries for Giant Papillary Conjunctivitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Allergic conjunctivitis is inflammation of the conjunctiva (the membrane covering the white part of the... more...

MalaCards: Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to keratoconjunctivitis and conjunctivitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Allograft rejection and Chemokine Signaling. The compounds ltc4 and pgd2 have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are hematopoietic system and respiratory system.

Aliases & Classifications for Giant Papillary Conjunctivitis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

giant papillary conjunctivitis 8 42
conjunctivitis, giant papillary 60
conjunctivitis giant papillary 44
gpc 42


External Ids:

Disease Ontology8 DOID:2457
MeSH34 D003233
SNOMED-CT56 231857004
NCIt39 C34507

Related Diseases for Giant Papillary Conjunctivitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to giant papillary conjunctivitis

Clinical Features for Giant Papillary Conjunctivitis

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Drugs & Therapeutics for Giant Papillary Conjunctivitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Giant Papillary Conjunctivitis

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Anatomical Context for Giant Papillary Conjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

32
Eye

Animal Models for Giant Papillary Conjunctivitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Giant Papillary Conjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5PRG2, CCL11, CCL24
2MP:00053888.2PRG2, CCL11, CCL24

Publications for Giant Papillary Conjunctivitis

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50PubMed
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Articles related to Giant Papillary Conjunctivitis:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Filtering bleb-induced giant papillary conjunctivitis. (17826299)
2008
2
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. (18216583)
2008
3
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. (17557145)
2007
4
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. (17760635)
2007
5
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
6
Giant papillary conjunctivitis--a review. (10337425)
1999
7
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. (10444049)
1999
8
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. (9124242)
1997
9
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
10
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. (8755197)
1996
11
Localised giant papillary conjunctivitis secondary to a dermolipoma. (7556754)
1995
12
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. (7586473)
1995
13
Causative factors in unilateral giant papillary conjunctivitis. (8495560)
1993
14
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. (8470716)
1993
15
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). (7910133)
1993
16
Meibomian gland function and giant papillary conjunctivitis. (8420369)
1993
17
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
18
Daily enzyme cleaning for giant papillary conjunctivitis. (1498575)
1992
19
Treatment of giant papillary conjunctivitis with cromolyn sodium. (1559288)
1992
20
Continued contact lens wear in patients with giant papillary conjunctivitis. (1904798)
1991
21
Giant papillary conjunctivitis. (2193971)
1990
22
Some unusual nonallergic causes of giant papillary conjunctivitis. (2095029)
1990
23
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. (2407379)
1990
24
Eosinophil granule major basic protein in contact lenses of patients with giant papillary conjunctivitis. (2199092)
1990
25
Association of giant papillary conjunctivitis with seasonal allergies. (2320363)
1990
26
Giant papillary conjunctivitis associated with elevated corneal deposits. (1706653)
1990
27
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. (2717140)
1989
28
Giant papillary conjunctivitis associated with rigid gas permeable contact lenses. (3208429)
1988
29
A review of contact lens induced giant papillary conjunctivitis. (3336050)
1988
30
Tear lysozyme and lactoferrin levels in giant papillary conjunctivitis and vernal conjunctivitis. (3147820)
1988
31
Giant papillary conjunctivitis associated with an extruded scleral buckle. Case report. (3619733)
1987
32
Giant papillary conjunctivitis. (3949453)
1986
33
Blepharoptosis associated with giant papillary conjunctivitis. (3778291)
1986
34
Suture barb giant papillary conjunctivitis. (6709289)
1984
35
Giant papillary conjunctivitis in connection with corneoscleral supramid (nylon) suture knots. (6720279)
1984
36
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6624827)
1983
37
Cromolyn treatment of giant papillary conjunctivitis. (6814405)
1982
38
Clinical aspects of giant papillary conjunctivitis. (7339618)
1981
39
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. (7234932)
1981
40
An immunopathologic study of giant papillary conjunctivitis associated with an ocular prosthesis. (7294096)
1981
41
Giant papillary conjunctivitis. (7239822)
1981
42
The clinical management of giant papillary conjunctivitis. (7304717)
1981
43
Mast cell ultrastructure. Comparison in contact lens-associated giant papillary conjunctivitis and vernal conjunctivitis. (7259602)
1981
44
Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. (7236092)
1981
45
Giant papillary conjunctivitis with ocular prostheses. (7362515)
1980
46
Giant papillary conjunctivitis: an overview. (448014)
1979
47
Giant papillary conjunctivitis with ocular prostheses. (444123)
1979
48
Soft contact lenses from patients with giant papillary conjunctivitis. (517610)
1979
49
Surface morphology of giant papillary conjunctivitis in contact lens wearers. (623198)
1978
50
Giant papillary conjunctivitis in contact lens wearers. (868969)
1977

Genetic Variations for Giant Papillary Conjunctivitis

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Expression for genes affiliated with Giant Papillary Conjunctivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Giant Papillary Conjunctivitis

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Pathways for genes affiliated with Giant Papillary Conjunctivitis

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29KEGG, 51QIAGEN, 12EMD Millipore
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Pathways related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.3PRG2, CCL11
2
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9.0CCL11, CCL24
3
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9.0CCL11, CCL24
4
Immune response CCR3 signaling in eosinophils
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9.0CCL24, CCL11
5
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8.5PRG2, CCL11, CCL24
6
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8.5PRG2, CCL11, CCL24

Compounds for genes affiliated with Giant Papillary Conjunctivitis

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1ltc4449.6PRG2, CCL11
2pgd2449.5PRG2, CCL11
3methacholine44 1110.5PRG2, CCL11
4allergens449.4PRG2, CCL11
5indomethacin44 59 28 1112.3PRG2, CCL11
6fmlp449.2PRG2, CCL11
7tarc449.2CCL24, CCL11
8ccl344 2810.1CCL11, CCL24
9histamine44 28 2410.8PRG2, CCL11, CCL24
10actinomycin d448.8PRG2, CCL11, CCL24
11superoxide44 249.7CCL24, CCL11, PRG2
12rantes448.7CCL11, CCL24
13oxygen44 249.5CCL24, CCL11, PRG2

GO Terms for genes affiliated with Giant Papillary Conjunctivitis

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16Gene Ontology
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Biological processes related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:0482459.3CCL11, CCL24
2positive regulation of Rac GTPase activityGO:0328559.3CCL11, CCL24
3positive regulation of actin filament polymerizationGO:0308389.2CCL11, CCL24
4positive regulation of endothelial cell proliferationGO:0019389.2CCL11, CCL24
5positive regulation of angiogenesisGO:0457669.1CCL24, CCL11
6cytoskeleton organizationGO:0070109.1CCL11, CCL24
7regulation of cell shapeGO:0083609.0CCL11, CCL24
8inflammatory responseGO:0069549.0CCL11, CCL24
9positive regulation of cell migrationGO:0303358.9CCL24, CCL11
10chemotaxisGO:0069358.7CCL24, CCL11
11immune responseGO:0069558.7CCL24, CCL11, PRG2

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.0CCL11, CCL24

Products for genes affiliated with Giant Papillary Conjunctivitis

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Sources for Giant Papillary Conjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet