MCID: GNT006
MIFTS: 36

Giant Papillary Conjunctivitis malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Giant Papillary Conjunctivitis

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Aliases & Descriptions for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 10 45 12
Conjunctivitis, Giant Papillary 65
 
Conjunctivitis Giant Papillary 47
Gpc 45

Classifications:



External Ids:

Disease Ontology10 DOID:2457
MeSH36 D003233
SNOMED-CT59 231857004
NCIt42 C34507
UMLS65 C0009769

Summaries for Giant Papillary Conjunctivitis

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MalaCards based summary: Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to keratoconjunctivitis and blepharitis, and has symptoms including conjunctival hyperemiaand injection site hypersensitivity. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways are CXCR3-mediated signaling events and IL4-mediated signaling events. Affiliated tissues include eye, heart and prostate, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Giant Papillary Conjunctivitis

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Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis30.4IL5, RNASE3
2blepharitis29.5CCL11, IL5, RNASE3
3papillary conjunctivitis28.4CCL11, CMA1, FPR1, IL5, LTF, RNASE3
4conjunctivitis10.8
5hypertensive encephalopathy10.3CCL11, LTF
6vernal conjunctivitis10.2
7blepharophimosis10.2CCL11, IL5
8cholesteatoma of attic10.2CCL11, IL5
9antley-bixler syndrome with genital anomalies and disordered steroidogenesis10.2CCL11, IL5
10lymphocytic colitis10.2LTF, RNASE3
11trabecular follicular adenocarcinoma10.2IL5, RNASE3
12anus disease10.2LTF, RNASE3
13kyphoscoliotic heart disease10.2IL5, RNASE3
14eosinophilic gastroenteritis10.2CCL11, IL5
15reactive arthritis10.2CCL11, RNASE3
16hepatitis e10.2CCL11, IL5
17status asthmaticus10.2IL5, RNASE3
18benign paroxysmal positional nystagmus10.1IL5, RNASE3
19non specific chronic endometritis10.1IL5, RNASE3
20skin conditions10.1IL5, RNASE3
21hypergonadotropic ovarian failure, familial or sporadic10.1IL5, RNASE3
22central nervous system childhood germ cell tumor10.1CCL11, IL5
23congenital disorder of glycosylation, type ih10.1CCL11, RNASE3
24timothy grass allergy10.1IL5, RNASE3
25hepatoid adenocarcinoma10.1IL5, RNASE3
26methylmalonic acidemia10.1FPR1, LTF
27hodgkin's lymphoma, nodular sclerosis10.1IL5, RNASE3
28postmenopausal atrophic vaginitis10.1CCL11, IL5
29viral gastritis10.0CCL11, IL5
30wissler's syndrome10.0IL5, RNASE3
31rectum signet ring adenocarcinoma10.0CCL11, LTF
32ptosis10.0
33vernal keratoconjunctivitis10.0
34collagen vi related muscular dystrophy10.0CMA1, RNASE3
35uterine corpus epithelioid leiomyoma9.9IL5, RNASE3
36bacterial gastritis9.9CCL11, IL5, RNASE3
37loeffler syndrome9.9CCL11, IL5, RNASE3
38superficial urinary bladder cancer9.9CCL11, IL5, RNASE3
39familial hyperlipidemia9.8CCL11, IL5, RNASE3
40retroperitoneal germ cell neoplasm9.8CCL11, IL5, RNASE3
41disseminated eosinophilic collagen disease9.8CCL11, IL5, RNASE3
42cataract9.8
43corneal deposit9.8
44conjunctival deposit9.8
45superior limbic keratoconjunctivitis9.8
46enamel caries9.8CCL11, IL5, RNASE3
47balkan nephropathy9.8CCL11, IL5, RNASE3
48keratinizing squamous cell carcinoma9.8CCL11, IL5
49acalculous cholecystitis9.8CCL11, IL5, RNASE3
50opioid abuse9.8CCL11, IL5, RNASE3

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to giant papillary conjunctivitis

Symptoms for Giant Papillary Conjunctivitis

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UMLS symptoms related to Giant Papillary Conjunctivitis:


conjunctival hyperemia, injection site hypersensitivity

Drugs & Therapeutics for Giant Papillary Conjunctivitis

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Drugs for Giant Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Loteprednol EtabonatePhase 44482034-46-6444025
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
 
Locort
Loteflam
Lotemax
Lotemax (TN)
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate
2Anti-Allergic AgentsPhase 41312

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%Active, not recruitingNCT01437982Phase 4

Search NIH Clinical Center for Giant Papillary Conjunctivitis

Genetic Tests for Giant Papillary Conjunctivitis

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Anatomical Context for Giant Papillary Conjunctivitis

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MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

33
Eye, Heart, Prostate, Thyroid, Skin, T cells, Monocytes

Animal Models for Giant Papillary Conjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Giant Papillary Conjunctivitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.6CCL11, CMA1, FPR1, IL5, LTF
2MP:00053877.3CCL11, CMA1, FPR1, IL5, LTF

Publications for Giant Papillary Conjunctivitis

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Articles related to Giant Papillary Conjunctivitis:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Giant papillary conjunctivitis. (18769199)
2008
2
Filtering bleb-induced giant papillary conjunctivitis. (17826299)
2008
3
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
4
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
5
Contact lens chemistry and giant papillary conjunctivitis. (12772728)
2003
6
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
7
Giant papillary conjunctivitis associated with an ocular prosthesis. (12366372)
2001
8
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
9
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
10
Giant papillary conjunctivitis--a review. (10337425)
1999
11
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. (9124242)
1997
12
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
13
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. (8755197)
1996
14
Causative factors in unilateral giant papillary conjunctivitis. (8495560)
1993
15
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. (8470716)
1993
16
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). (7910133)
1993
17
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
18
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
19
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
20
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. (1846131)
1991
21
Continued contact lens wear in patients with giant papillary conjunctivitis. (1904798)
1991
22
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
23
Giant papillary conjunctivitis. (2193971)
1990
24
Some unusual nonallergic causes of giant papillary conjunctivitis. (2095029)
1990
25
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. (2717140)
1989
26
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
27
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989
28
Contact lens induced giant papillary conjunctivitis: a retrospective study. (2708768)
1989
29
HPLC analysis of tear proteins in giant papillary conjunctivitis. (2625085)
1989
30
Giant papillary conjunctivitis associated with rigid gas permeable contact lenses. (3208429)
1988
31
Giant papillary conjunctivitis. (3053490)
1988
32
A review of contact lens induced giant papillary conjunctivitis. (3336050)
1988
33
Giant papillary conjunctivitis. (3949453)
1986
34
Giant papillary conjunctivitis from an exposed prolene suture. (3756614)
1986
35
Suture barb giant papillary conjunctivitis. (6709289)
1984
36
Giant papillary conjunctivitis following cataract extraction. (6367598)
1984
37
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6702985)
1984
38
Giant papillary conjunctivitis in connection with corneoscleral supramid (nylon) suture knots. (6720279)
1984
39
Clinical aspects of giant papillary conjunctivitis. (7339618)
1981
40
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. (7234932)
1981
41
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
42
An immunopathologic study of giant papillary conjunctivitis associated with an ocular prosthesis. (7294096)
1981
43
Giant papillary conjunctivitis. (7239822)
1981
44
Giant papillary conjunctivitis with ocular prostheses. (7362515)
1980
45
Giant papillary conjunctivitis: an overview. (448014)
1979
46
Giant papillary conjunctivitis and ptosis in a contact lens wearer. (458521)
1979
47
Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted. (443320)
1979
48
Surface morphology of giant papillary conjunctivitis in contact lens wearers. (623198)
1978
49
Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. (714378)
1978
50

Variations for Giant Papillary Conjunctivitis

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Expression for genes affiliated with Giant Papillary Conjunctivitis

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Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.

Pathways for genes affiliated with Giant Papillary Conjunctivitis

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GO Terms for genes affiliated with Giant Papillary Conjunctivitis

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Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00069558.6CCL11, CMA1, IL5

Sources for Giant Papillary Conjunctivitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet