MCID: GNT006
MIFTS: 40

Giant Papillary Conjunctivitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Giant Papillary Conjunctivitis

MalaCards integrated aliases for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 12 72 49 14
Conjunctivitis, Giant Papillary 69
Conjunctivitis Giant Papillary 51
Gpc 49

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:2457
MeSH 41 D003233
NCIt 46 C34507
SNOMED-CT 64 231857004
UMLS 69 C0009769

Summaries for Giant Papillary Conjunctivitis

MalaCards based summary : Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to conjunctivitis and vernal keratoconjunctivitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and neutrophil.

Wikipedia : 72 Allergic conjunctivitis is inflammation of the conjunctiva (the membrane covering the white part of the... more...

Related Diseases for Giant Papillary Conjunctivitis

Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 conjunctivitis 30.7 CCL11 CXCL8 IL4
2 vernal keratoconjunctivitis 30.3 CCL11 IL4
3 blepharitis 30.1 CCL11 IL4
4 keratoconjunctivitis 29.6 CCL11 CXCL8 IL4
5 papillary conjunctivitis 29.6 CCL11 CXCL8 IL11 IL4 IL7
6 blood group, gerbich system 11.3
7 blepharoconjunctivitis 10.3 CCL11 IL4
8 angiostrongyliasis 10.3 CCL11 IL4
9 gastrointestinal allergy 10.3 CCL11 IL4
10 eosinophilic meningitis 10.3 CCL11 IL4
11 chronic conjunctivitis 10.3 CCL11 IL4
12 eosinophilic gastritis 10.3 CCL11 IL4
13 kimura disease 10.3 CCL11 IL4
14 folliculitis 10.3 CCL11 IL4
15 conjunctival disease 10.2 CCL11 IL4
16 pulmonary eosinophilia 10.2 CCL11 IL4
17 onchocerciasis 10.2 CCL11 IL4
18 dermatitis herpetiformis 10.2 CCL11 IL4
19 leukocyte disease 10.2 CCL11 IL4
20 b-cell growth factor 10.2 IL4 IL7
21 natural killer cell leukemia 10.2 IL4 IL7
22 vernal conjunctivitis 10.2
23 severe combined immunodeficiency, x-linked 10.2 IL4 IL7
24 sezary's disease 10.1 IL4 IL7
25 keratoconjunctivitis sicca 10.1 IL4 LTF
26 combined immunodeficiency, x-linked 10.0 IL4 IL7
27 scabies 10.0 CCL11 CXCL8
28 cutaneous t cell lymphoma 10.0 IL4 IL7
29 vulvovaginitis 10.0 CCL11 CXCL8
30 tungiasis 10.0 CXCL8 IL4
31 opisthorchiasis 10.0 CXCL8 IL4
32 ptosis 10.0
33 common cold 10.0 CCL11 CXCL8
34 interstitial cystitis 9.9 CXCL8 IL4
35 esophagitis 9.9 CCL11 CXCL8
36 brucellosis 9.9 CXCL8 IL4
37 acute monoblastic leukemia 9.9 CXCL8 IL7
38 tonsillitis 9.9 CXCL8 IL4
39 aggressive periodontitis 9.9 CXCL8 IL4
40 allergic contact dermatitis 9.9 CXCL8 IL4
41 contact dermatitis 9.9 CXCL8 IL4
42 bronchitis 9.9 CCL11 CXCL8
43 idiopathic interstitial pneumonia 9.9 CXCL8 IL4
44 bone inflammation disease 9.9 CXCL8 IL4
45 pouchitis 9.9 CXCL8 LTF
46 felty syndrome 9.8 CXCL8 LTF
47 toxic shock syndrome 9.8 CXCL8 IL4
48 haemophilus influenzae 9.8 CXCL8 LTF
49 trypanosomiasis 9.8 CXCL8 IL4
50 oral candidiasis 9.8 CXCL8 LTF

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to Giant Papillary Conjunctivitis

Symptoms & Phenotypes for Giant Papillary Conjunctivitis

Drugs & Therapeutics for Giant Papillary Conjunctivitis

Drugs for Giant Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 129260-79-3, 82034-46-6 9865442 444025
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Anti-Allergic Agents Phase 4
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4
9 Gastrointestinal Agents Phase 4
10 glucocorticoids Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Methylprednisolone acetate Phase 4
15 Methylprednisolone Hemisuccinate Phase 4
16 Neuroprotective Agents Phase 4
17 Peripheral Nervous System Agents Phase 4
18 Prednisolone acetate Phase 4
19 Prednisolone hemisuccinate Phase 4
20 Prednisolone phosphate Phase 4
21 Protective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Active, not recruiting NCT01437982 Phase 4 Loteprednol Etabonate;Prednisolone Acetate 1% Oph Susp

Search NIH Clinical Center for Giant Papillary Conjunctivitis

Genetic Tests for Giant Papillary Conjunctivitis

Anatomical Context for Giant Papillary Conjunctivitis

MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

38
Eye, Neutrophil

Publications for Giant Papillary Conjunctivitis

Articles related to Giant Papillary Conjunctivitis:

(show top 50) (show all 100)
# Title Authors Year
1
Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis. ( 29260110 )
2017
2
Giant papillary conjunctivitis. ( 18282547 )
2008
3
Filtering bleb-induced giant papillary conjunctivitis. ( 17826299 )
2008
4
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. ( 18216583 )
2008
5
Giant papillary conjunctivitis. ( 18769199 )
2008
6
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. ( 17760635 )
2007
7
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. ( 17557145 )
2007
8
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. ( 16767372 )
2006
9
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. ( 15677951 )
2005
10
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 14566648 )
2003
11
Contact lens chemistry and giant papillary conjunctivitis. ( 12772728 )
2003
12
Giant papillary conjunctivitis associated with an ocular prosthesis. ( 12366372 )
2001
13
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study ( 10844086 )
2000
14
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. ( 15326900 )
2000
15
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. ( 10444049 )
1999
16
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. ( 10410873 )
1999
17
Giant papillary conjunctivitis--a review. ( 10337425 )
1999
18
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. ( 10703125 )
1999
19
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 9785608 )
1998
20
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. ( 9124242 )
1997
21
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. ( 9001768 )
1997
22
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. ( 8755197 )
1996
23
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. ( 7586473 )
1995
24
Contact lens type, material, and deposits and giant papillary conjunctivitis. ( 7712614 )
1995
25
Localised giant papillary conjunctivitis secondary to a dermolipoma. ( 7556754 )
1995
26
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. ( 22827277 )
1995
27
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. ( 7995075 )
1994
28
Giant papillary conjunctivitis. ( 7886881 )
1994
29
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). ( 7910133 )
1993
30
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. ( 8319490 )
1993
31
Meibomian gland function and giant papillary conjunctivitis. ( 8420369 )
1993
32
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. ( 8470716 )
1993
33
Unusual causes of giant papillary conjunctivitis. ( 8458237 )
1993
34
Meibomian gland function and giant papillary conjunctivitis. ( 8420368 )
1993
35
Causative factors in unilateral giant papillary conjunctivitis. ( 8495560 )
1993
36
Treatment of giant papillary conjunctivitis with cromolyn sodium. ( 1559288 )
1992
37
Daily enzyme cleaning for giant papillary conjunctivitis. ( 1498575 )
1992
38
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. ( 1499122 )
1992
39
Meibomian gland function and giant papillary conjunctivitis. ( 1642294 )
1992
40
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. ( 1499118 )
1992
41
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. ( 1846131 )
1991
42
Continued contact lens wear in patients with giant papillary conjunctivitis. ( 1904798 )
1991
43
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. ( 2407379 )
1990
44
Eosinophil granule major basic protein in contact lenses of patients with giant papillary conjunctivitis. ( 2199092 )
1990
45
Giant papillary conjunctivitis associated with elevated corneal deposits. ( 1706653 )
1990
46
Association of giant papillary conjunctivitis with seasonal allergies. ( 2320363 )
1990
47
Some unusual nonallergic causes of giant papillary conjunctivitis. ( 2095029 )
1990
48
Giant papillary conjunctivitis. ( 2193971 )
1990
49
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. ( 2196302 )
1990
50
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. ( 2717140 )
1989

Variations for Giant Papillary Conjunctivitis

Expression for Giant Papillary Conjunctivitis

Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.

Pathways for Giant Papillary Conjunctivitis

Pathways related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 CCL11 CXCL8 IL11 IL4 IL7 LTF
2
Show member pathways
13.45 CCL11 CXCL8 IL11 IL4 IL7
3
Show member pathways
13.29 CCL11 CXCL8 IL11 IL4 IL7
4
Show member pathways
13.16 CCL11 CXCL8 IL11 IL4 IL7
5
Show member pathways
13.04 CCL11 CXCL8 IL11 IL4 IL7
6
Show member pathways
12.99 CCL11 CXCL8 IL11 IL4 IL7
7
Show member pathways
12.87 CCL11 CXCL8 IL11 IL4 IL7
8
Show member pathways
12.54 CCL11 CXCL8 IL4
9 12.53 CXCL8 IL4 IL7
10
Show member pathways
12.07 IL11 IL4 IL7
11
Show member pathways
12.04 CCL11 CXCL8 IL4
12 11.7 IL11 IL4 IL7
13 11.67 CCL11 CXCL8 IL4
14 11.59 CXCL8 IL11
15 11.53 CXCL8 IL4
16 11.53 IL11 IL4 IL7
17 11.51 IL4 IL7
18
Show member pathways
11.49 CXCL8 IL4
19
Show member pathways
11.47 CCL11 CXCL8 IL11 IL4
20 11.4 CCL11 IL4
21 11.3 CCL11 CXCL8 IL4
22 11.28 CXCL8 IL4
23 11.24 CCL11 IL4
24 11.07 IL4 IL7
25 10.91 IL11 IL4 IL7
26 10.46 CCL11 CXCL8 IL11 IL4 IL7
27 10.25 CCL11 CXCL8 IL11 IL4 IL7

GO Terms for Giant Papillary Conjunctivitis

Cellular components related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CXCL8 IL11 IL4 IL7 LTF
2 extracellular space GO:0005615 9.1 CCL11 CXCL8 IL11 IL4 IL7 LTF

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.69 IL4 IL7 LTF
2 cellular response to interleukin-1 GO:0071347 9.49 CCL11 CXCL8
3 chemokine-mediated signaling pathway GO:0070098 9.48 CCL11 CXCL8
4 B cell differentiation GO:0030183 9.46 IL11 IL4
5 neutrophil chemotaxis GO:0030593 9.43 CCL11 CXCL8
6 humoral immune response GO:0006959 9.4 IL7 LTF
7 positive regulation of B cell proliferation GO:0030890 9.37 IL4 IL7
8 chemotaxis GO:0006935 9.33 CCL11 CXCL8 IL4
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.32 IL11 IL4
10 positive regulation of T cell differentiation GO:0045582 9.26 IL4 IL7
11 immune response GO:0006955 9.26 CCL11 CXCL8 IL4 IL7
12 regulation of receptor activity GO:0010469 9.02 CCL11 CXCL8 IL11 IL4 IL7

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL11 CXCL8
2 cytokine receptor binding GO:0005126 9.16 IL4 IL7
3 growth factor activity GO:0008083 9.13 IL11 IL4 IL7
4 cytokine activity GO:0005125 9.02 CCL11 CXCL8 IL11 IL4 IL7

Sources for Giant Papillary Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....