MCID: GNT006
MIFTS: 37

Giant Papillary Conjunctivitis malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Giant Papillary Conjunctivitis

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Aliases & Descriptions for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 11 48 13
Conjunctivitis, Giant Papillary 68
 
Conjunctivitis Giant Papillary 50
Gpc 48

Classifications:



External Ids:

Disease Ontology11 DOID:2457
MeSH39 D003233
SNOMED-CT62 231857004
NCIt45 C34507

Summaries for Giant Papillary Conjunctivitis

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MalaCards based summary: Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to papillary conjunctivitis and corneal deposit, and has symptoms including conjunctival hyperemia and injection site hypersensitivity. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways are Th2 Differentiation Pathway and IL4-mediated signaling events. Affiliated tissues include eye and neutrophil.

Related Diseases for Giant Papillary Conjunctivitis

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Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1papillary conjunctivitis31.7CCL11, IL4
2corneal deposit29.5CXCL8, IL6
3conjunctivitis10.7
4dioctophymiasis10.4CCL11, IL4
5epididymis adenocarcinoma10.4CCL11, IL4
6bacterial gastritis10.4CCL11, IL4
7intracranial hypertension10.4CCL11, IL4
8apple allergy10.4CCL11, IL4
9cervix melanoma10.4CCL11, IL4
10central nervous system origin vertigo10.4CCL11, IL4
11pituitary hypoplasia10.4CCL11, IL4
12dacryoadenitis10.4CCL11, IL4
13gait apraxia10.4CCL11, IL4
14juvenile dermatitis herpetiformis10.4CCL11, IL4
15melanoacanthoma10.4CCL11, IL4
16sarcoid meningitis10.3CCL11, IL4
17breast fibroadenosis10.3IL4, IL7
18interleukin-7 receptor alpha deficiency10.3IL4, IL7
19loeffler syndrome10.3CCL11, IL4
20gonadal disease10.3CCL11, CXCL8
21basidiobolomycosis10.2CXCL8, IL4
22plantar wart10.2CXCL8, IL4
23benign fibrous mesothelioma10.2CXCL8, IL4
24lymphangiectasia, intestinal10.2CXCL8, LTF
253-alpha hydroxyacyl-coa dehydrogenase deficiency10.2CXCL8, LTF
26pseudoretinitis pigmentosa10.2CXCL8, LTF
27vernal conjunctivitis10.1
28benign mammary dysplasia10.1CCL11, IL6
29spastic entropion10.1CXCL8, LTF
30subcorneal pustular dermatosis10.1CXCL8, IL4
31hypertensive encephalopathy10.1CCL11, IL4
32lymphocytic colitis10.1IL4, IL6
33renal cell carcinoma 410.0IL4, IL6
34scn8a encephalopathy10.0IL4, IL6
35philophthalmiasis10.0IL4, IL6
36anti-basement membrane glomerulonephritis10.0IL4, IL6
37transmitted_by10.0CCL11, IL4
38senile cataract10.0IL4, IL6
39nonspecific interstitial pneumonia10.0CXCL8, IL4
40oesophagostomiasis10.0IL4, IL6
41gonococcal keratitis10.0IL4, IL6
42orbital periostitis10.0IL4, IL6
43polyradiculoneuropathy10.0IL6, IL7
44keratoconjunctivitis10.0
45opportunistic bacterial infectious disease9.9IL4, IL6
46idiopathic interstitial pneumonia9.9IL4, IL6
47thymus lymphoma9.9IL6, LTF
48tarsal tunnel syndrome9.9CXCL8, IL6
49maligant granulosa cell tumor of ovary9.9CXCL8, IL6
50benign adult familial myoclonic epilepsy9.9CXCL8, IL6

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to giant papillary conjunctivitis

Symptoms & Phenotypes for Giant Papillary Conjunctivitis

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UMLS symptoms related to Giant Papillary Conjunctivitis:


conjunctival hyperemia, injection site hypersensitivity

Drugs & Therapeutics for Giant Papillary Conjunctivitis

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Drugs for Giant Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LoteprednolapprovedPhase 45082034-46-6, 129260-79-3444025, 9865442
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
Locort
 
Loteflam
Lotemax
Lotemax (TN)
Loteprednol
Loteprednol Etabonate
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loteprednolum
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate
2Anti-Allergic AgentsPhase 41490

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%Unknown statusNCT01437982Phase 4

Search NIH Clinical Center for Giant Papillary Conjunctivitis

Genetic Tests for Giant Papillary Conjunctivitis

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Anatomical Context for Giant Papillary Conjunctivitis

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MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

36
Eye, Neutrophil

Publications for Giant Papillary Conjunctivitis

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Articles related to Giant Papillary Conjunctivitis:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Giant papillary conjunctivitis. (18769199)
2008
2
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. (18216583)
2008
3
Filtering bleb-induced giant papillary conjunctivitis. (17826299)
2008
4
Giant papillary conjunctivitis. (18282547)
2008
5
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. (17557145)
2007
6
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. (17760635)
2007
7
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
8
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
9
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
10
Contact lens chemistry and giant papillary conjunctivitis. (12772728)
2003
11
Giant papillary conjunctivitis associated with an ocular prosthesis. (12366372)
2001
12
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
13
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. (15326900)
2000
14
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
15
Giant papillary conjunctivitis--a review. (10337425)
1999
16
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. (10444049)
1999
17
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. (10410873)
1999
18
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. (9785608)
1998
19
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
20
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. (9124242)
1997
21
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. (8755197)
1996
22
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. (7586473)
1995
23
Localised giant papillary conjunctivitis secondary to a dermolipoma. (7556754)
1995
24
Contact lens type, material, and deposits and giant papillary conjunctivitis. (7712614)
1995
25
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. (22827277)
1995
26
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. (7995075)
1994
27
Giant papillary conjunctivitis. (7886881)
1994
28
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
29
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
30
Causative factors in unilateral giant papillary conjunctivitis. (8495560)
1993
31
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. (8470716)
1993
32
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). (7910133)
1993
33
Meibomian gland function and giant papillary conjunctivitis. (8420369)
1993
34
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. (8319490)
1993
35
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
36
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. (1499118)
1992
37
Meibomian gland function and giant papillary conjunctivitis. (1642294)
1992
38
Daily enzyme cleaning for giant papillary conjunctivitis. (1498575)
1992
39
Treatment of giant papillary conjunctivitis with cromolyn sodium. (1559288)
1992
40
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. (1846131)
1991
41
Continued contact lens wear in patients with giant papillary conjunctivitis. (1904798)
1991
42
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. (2407379)
1990
43
Giant papillary conjunctivitis associated with elevated corneal deposits. (1706653)
1990
44
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
45
Giant papillary conjunctivitis. (2193971)
1990
46
Some unusual nonallergic causes of giant papillary conjunctivitis. (2095029)
1990
47
Eosinophil granule major basic protein in contact lenses of patients with giant papillary conjunctivitis. (2199092)
1990
48
Association of giant papillary conjunctivitis with seasonal allergies. (2320363)
1990
49
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
50
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989

Variations for Giant Papillary Conjunctivitis

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Expression for genes affiliated with Giant Papillary Conjunctivitis

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Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.

Pathways for genes affiliated with Giant Papillary Conjunctivitis

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Pathways related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
19.6CCL11, IL4
29.6CCL11, IL4
39.2IL4, IL6
49.2IL4, IL6
59.2IL4, IL6
69.0CXCL8, IL6
79.0CXCL8, IL6
89.0CXCL8, IL6
99.0CXCL8, IL6
109.0CXCL8, IL6
119.0CXCL8, IL6
129.0CXCL8, IL6
138.7IL4, IL6, IL7
148.7IL4, IL6, IL7
158.7IL4, IL6, IL7
168.6CCL11, CXCL8, IL6
178.6CXCL8, IL4, IL6
188.6CXCL8, IL4, IL6
19
Show member pathways
8.6CXCL8, IL4, IL6
20
Show member pathways
8.2CCL11, CXCL8, IL4, IL6
21
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
22
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
23
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
24
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
25
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
267.6CCL11, CXCL8, IL4, IL6, IL7

GO Terms for genes affiliated with Giant Papillary Conjunctivitis

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Cellular components related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.3CCL11, CXCL8, IL6, IL7, LTF
2extracellular spaceGO:00056157.1CCL11, CXCL8, IL4, IL6, IL7, LTF

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1innate immune response in mucosaGO:000222710.2IL4, LTF
2chemokine-mediated signaling pathwayGO:007009810.2CCL11, CXCL8
3negative regulation of extrinsic apoptotic signaling pathwayGO:200123710.1IL4, IL7
4positive regulation of B cell proliferationGO:003089010.1IL4, IL7
5neutrophil chemotaxisGO:003059310.1CCL11, CXCL8
6positive regulation of T cell differentiationGO:004558210.0IL4, IL7
7monocyte chemotaxisGO:00025489.9CCL11, IL6
8defense response to protozoanGO:00428329.9IL4, IL6
9positive regulation of B cell activationGO:00508719.8IL4, IL6
10chemotaxisGO:00069359.7CCL11, CXCL8, IL4
11positive regulation of osteoblast differentiationGO:00456699.7IL6, LTF
12positive regulation of T cell proliferationGO:00421029.7IL4, IL6
13cellular response to interleukin-1GO:00713479.4CCL11, CXCL8, IL6
14cellular response to tumor necrosis factorGO:00713569.4CCL11, CXCL8, IL6
15humoral immune responseGO:00069599.3IL6, IL7, LTF
16inflammatory responseGO:00069549.3CCL11, CXCL8, IL6
17response to cytokineGO:00340979.2IL4, IL6
18negative regulation of apoptotic processGO:00430668.8IL4, IL6, IL7, LTF

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:000800910.1CCL11, CXCL8
2cytokine activityGO:00051259.2IL4, IL6, IL7
3growth factor activityGO:00080838.7IL4, IL6, IL7

Sources for Giant Papillary Conjunctivitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet