GPC
MCID: GNT006
MIFTS: 37

Giant Papillary Conjunctivitis (GPC) malady

Summaries for Giant Papillary Conjunctivitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Allergic conjunctivitis is inflammation of the conjunctiva (the membrane covering the white part of the... more...

MalaCards: Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to keratoconjunctivitis and conjunctivitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Allograft rejection and Chemokine Signaling. The compounds ltc4 and pgd2 have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are hematopoietic system and respiratory system.

Aliases & Classifications for Giant Papillary Conjunctivitis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

giant papillary conjunctivitis 8 42
conjunctivitis, giant papillary 60
conjunctivitis giant papillary 44
gpc 42


External Ids:

Disease Ontology8 DOID:2457
MeSH34 D003233
SNOMED-CT56 231857004
NCIt39 C34507

Related Diseases for Giant Papillary Conjunctivitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to giant papillary conjunctivitis

Clinical Features for Giant Papillary Conjunctivitis

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Drugs & Therapeutics for Giant Papillary Conjunctivitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Giant Papillary Conjunctivitis

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Genetic Tests for Giant Papillary Conjunctivitis

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Anatomical Context for Giant Papillary Conjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

32
Eye

Animal Models for Giant Papillary Conjunctivitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Giant Papillary Conjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5PRG2, CCL11, CCL24
2MP:00053888.2PRG2, CCL11, CCL24

Publications for Giant Papillary Conjunctivitis

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50PubMed
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Articles related to Giant Papillary Conjunctivitis:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. (18216583)
2008
2
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
3
Contact lens chemistry and giant papillary conjunctivitis. (12772728)
2003
4
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
5
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. (15326900)
2000
6
Giant papillary conjunctivitis--a review. (10337425)
1999
7
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. (9785608)
1998
8
Localised giant papillary conjunctivitis secondary to a dermolipoma. (7556754)
1995
9
Giant papillary conjunctivitis. (7886881)
1994
10
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
11
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. (8319490)
1993
12
Surgical treatment and desensitization therapy of giant papillary allergic conjunctivitis. (1484672)
1992
13
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. (1499118)
1992
14
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. (1846131)
1991
15
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
16
Giant papillary conjunctivitis. (2193971)
1990
17
Association of giant papillary conjunctivitis with seasonal allergies. (2320363)
1990
18
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. (2717140)
1989
19
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
20
Contact lens induced giant papillary conjunctivitis: a retrospective study. (2708768)
1989
21
HPLC analysis of tear proteins in giant papillary conjunctivitis. (2625085)
1989
22
Giant papillary conjunctivitis associated with rigid gas permeable contact lenses. (3208429)
1988
23
Giant papillary conjunctivitis. (3053490)
1988
24
Pathology and treatment of giant papillary conjunctivitis. I. The U.S. perspective. (3664549)
1987
25
Pathology and treatment of giant papillary conjunctivitis. II. The British perspective. (3117367)
1987
26
Giant papillary conjunctivitis. (3949453)
1986
27
Giant papillary conjunctivitis from an exposed prolene suture. (3756614)
1986
28
Caution regarding treatment of giant papillary conjunctivitis. (3778271)
1986
29
Giant papillary conjunctivitis. (3771999)
1986
30
Clinical management and control of giant papillary conjunctivitis secondary to contact lens wear. (3958418)
1986
31
Giant papillary conjunctivitis following cataract extraction. (6367598)
1984
32
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6702985)
1984
33
Giant papillary conjunctivitis in connection with corneoscleral supramid (nylon) suture knots. (6720279)
1984
34
Treatment of contact lens-induced giant papillary conjunctivitis. (6439429)
1984
35
Transient ptosis secondary to giant papillary conjunctivitis in a hydrogel lens patient. (6643895)
1983
36
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6624827)
1983
37
Contrast sensitivity changes in patients with giant papillary conjunctivitis associated with contact lens wear. (6616805)
1983
38
Focal giant papillary conjunctivitis from retained contact lenses. (7181352)
1982
39
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
40
Giant papillary conjunctivitis. (7239822)
1981
41
Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. (7236092)
1981
42
Giant papillary conjunctivitis. (6934657)
1980
43
Giant papillary conjunctivitis--a closer look. (6989883)
1980
44
Giant papillary conjunctivitis: an overview. (448014)
1979
45
Giant papillary conjunctivitis and ptosis in a contact lens wearer. (458521)
1979
46
Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted. (443320)
1979
47
Russell bodies in contact-lens-associated giant papillary conjunctivitis. (217320)
1979
48
Soft contact lenses from patients with giant papillary conjunctivitis. (517610)
1979
49
Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. (714378)
1978
50
Giant papillary conjunctivitis (secondary vernal) in association with contact lens wear. (285506)
1978

Genetic Variations for Giant Papillary Conjunctivitis

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Expression for genes affiliated with Giant Papillary Conjunctivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Giant Papillary Conjunctivitis

Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.

Pathways for genes affiliated with Giant Papillary Conjunctivitis

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29KEGG, 51QIAGEN, 12EMD Millipore
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Pathways related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.3PRG2, CCL11
2
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9.0CCL11, CCL24
3
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9.0CCL11, CCL24
4
Immune response CCR3 signaling in eosinophils
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9.0CCL24, CCL11
5
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8.5PRG2, CCL11, CCL24
6
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8.5PRG2, CCL11, CCL24

Compounds for genes affiliated with Giant Papillary Conjunctivitis

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1ltc4449.6PRG2, CCL11
2pgd2449.5PRG2, CCL11
3methacholine44 1110.5PRG2, CCL11
4allergens449.4PRG2, CCL11
5indomethacin44 59 28 1112.3PRG2, CCL11
6fmlp449.2PRG2, CCL11
7tarc449.2CCL24, CCL11
8ccl344 2810.1CCL11, CCL24
9histamine44 28 2410.8PRG2, CCL11, CCL24
10actinomycin d448.8PRG2, CCL11, CCL24
11superoxide44 249.7CCL24, CCL11, PRG2
12rantes448.7CCL11, CCL24
13oxygen44 249.5CCL24, CCL11, PRG2

GO Terms for genes affiliated with Giant Papillary Conjunctivitis

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16Gene Ontology
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Biological processes related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:0482459.3CCL11, CCL24
2positive regulation of Rac GTPase activityGO:0328559.3CCL11, CCL24
3positive regulation of actin filament polymerizationGO:0308389.2CCL11, CCL24
4positive regulation of endothelial cell proliferationGO:0019389.2CCL11, CCL24
5positive regulation of angiogenesisGO:0457669.1CCL24, CCL11
6cytoskeleton organizationGO:0070109.1CCL11, CCL24
7regulation of cell shapeGO:0083609.0CCL11, CCL24
8inflammatory responseGO:0069549.0CCL11, CCL24
9positive regulation of cell migrationGO:0303358.9CCL24, CCL11
10chemotaxisGO:0069358.7CCL24, CCL11
11immune responseGO:0069558.7CCL24, CCL11, PRG2

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.0CCL11, CCL24

Products for genes affiliated with Giant Papillary Conjunctivitis

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  • Antibodies
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Sources for Giant Papillary Conjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet