GPC
MCID: GNT006
MIFTS: 40

Giant Papillary Conjunctivitis (GPC) malady

Rare diseases, Eye diseases categories

Summaries for Giant Papillary Conjunctivitis

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Allergic conjunctivitis is inflammation of the conjunctiva (the membrane covering the white part of the... more...

MalaCards: Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to vernal keratoconjunctivitis and conjunctivitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Allograft rejection and Chemokine Signaling. The compounds ltc4 and pgd2 have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are immune system and respiratory system.

Aliases & Classifications for Giant Papillary Conjunctivitis

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

giant papillary conjunctivitis 9 44
conjunctivitis, giant papillary 63
conjunctivitis giant papillary 46
gpc 44


External Ids:

Disease Ontology9 DOID:2457
MeSH36 D003233
SNOMED-CT59 231857004
NCIt41 C34507

Related Diseases for Giant Papillary Conjunctivitis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to giant papillary conjunctivitis

Symptoms for Giant Papillary Conjunctivitis

About this section

Drugs & Therapeutics for Giant Papillary Conjunctivitis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Giant Papillary Conjunctivitis

Drug clinical trials:

Search ClinicalTrials for Giant Papillary Conjunctivitis

Search NIH Clinical Center for Giant Papillary Conjunctivitis

Search CenterWatch for Giant Papillary Conjunctivitis

Genetic Tests for Giant Papillary Conjunctivitis

About this section

Anatomical Context for Giant Papillary Conjunctivitis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

34
Eye

Animal Models for Giant Papillary Conjunctivitis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Giant Papillary Conjunctivitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5CCL11, CCL24, PRG2
2MP:00053888.4CCL11, CCL24, PRG2
3MP:00053978.2CCL11, CCL24, PRG2

Publications for Giant Papillary Conjunctivitis

About this section
Sources:
53PubMed
See all sources

Articles related to Giant Papillary Conjunctivitis:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Giant papillary conjunctivitis. (18769199)
2008
2
Filtering bleb-induced giant papillary conjunctivitis. (17826299)
2008
3
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
4
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
5
Contact lens chemistry and giant papillary conjunctivitis. (12772728)
2003
6
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
7
Giant papillary conjunctivitis associated with an ocular prosthesis. (12366372)
2001
8
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
9
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
10
Giant papillary conjunctivitis--a review. (10337425)
1999
11
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. (9124242)
1997
12
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
13
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. (8755197)
1996
14
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. (7995075)
1994
15
Causative factors in unilateral giant papillary conjunctivitis. (8495560)
1993
16
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). (7910133)
1993
17
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
18
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
19
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
20
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. (1846131)
1991
21
Continued contact lens wear in patients with giant papillary conjunctivitis. (1904798)
1991
22
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
23
Giant papillary conjunctivitis. (2193971)
1990
24
Some unusual nonallergic causes of giant papillary conjunctivitis. (2095029)
1990
25
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. (2717140)
1989
26
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
27
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989
28
Contact lens induced giant papillary conjunctivitis: a retrospective study. (2708768)
1989
29
HPLC analysis of tear proteins in giant papillary conjunctivitis. (2625085)
1989
30
Giant papillary conjunctivitis associated with rigid gas permeable contact lenses. (3208429)
1988
31
Giant papillary conjunctivitis. (3053490)
1988
32
A review of contact lens induced giant papillary conjunctivitis. (3336050)
1988
33
Giant papillary conjunctivitis. (3949453)
1986
34
Giant papillary conjunctivitis from an exposed prolene suture. (3756614)
1986
35
Suture barb giant papillary conjunctivitis. (6709289)
1984
36
Giant papillary conjunctivitis following cataract extraction. (6367598)
1984
37
Tear immunoglobulins in giant papillary conjunctivitis induced by contact lenses. (6702985)
1984
38
Giant papillary conjunctivitis in connection with corneoscleral supramid (nylon) suture knots. (6720279)
1984
39
Transient ptosis secondary to giant papillary conjunctivitis in a hydrogel lens patient. (6643895)
1983
40
Clinical aspects of giant papillary conjunctivitis. (7339618)
1981
41
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. (7234932)
1981
42
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
43
An immunopathologic study of giant papillary conjunctivitis associated with an ocular prosthesis. (7294096)
1981
44
Giant papillary conjunctivitis. (7239822)
1981
45
Giant papillary conjunctivitis with ocular prostheses. (7362515)
1980
46
Giant papillary conjunctivitis: an overview. (448014)
1979
47
Giant papillary conjunctivitis and ptosis in a contact lens wearer. (458521)
1979
48
Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted. (443320)
1979
49
Surface morphology of giant papillary conjunctivitis in contact lens wearers. (623198)
1978
50
Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. (714378)
1978

Variations for Giant Papillary Conjunctivitis

About this section

Expression for genes affiliated with Giant Papillary Conjunctivitis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Giant Papillary Conjunctivitis

Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.

Pathways for genes affiliated with Giant Papillary Conjunctivitis

About this section
Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 55R&D Systems, 56Reactome
See all sources

Compounds for genes affiliated with Giant Papillary Conjunctivitis

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
See all sources

Compounds related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1ltc4469.6PRG2, CCL11
2pgd2469.6CCL11, PRG2
3methacholine46 52 1211.6CCL11, PRG2
4allergens469.5CCL11, PRG2
5fmlp469.4CCL11, PRG2
6indomethacin46 30 62 1212.3CCL11, PRG2
7heparin46 30 25 1212.3CCL11, PRG2
8tarc469.3CCL11, CCL24
9ccl346 3010.2CCL24, CCL11
10rantes469.1CCL24, CCL11
11genistein46 30 62 3 25 1214.0CCL11, PRG2
12histamine46 30 2510.8CCL11, CCL24, PRG2
13actinomycin d468.8PRG2, CCL24, CCL11
14superoxide46 259.8CCL11, CCL24, PRG2
15oxygen46 259.7CCL11, CCL24, PRG2
16calcium46 52 25 1211.4PRG2, CCL24, CCL11

GO Terms for genes affiliated with Giant Papillary Conjunctivitis

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:0482459.3CCL11, CCL24
2positive regulation of Rac GTPase activityGO:0328559.2CCL24, CCL11
3positive regulation of actin filament polymerizationGO:0308389.2CCL11, CCL24
4positive regulation of endothelial cell proliferationGO:0019389.2CCL11, CCL24
5positive regulation of angiogenesisGO:0457669.1CCL24, CCL11
6cytoskeleton organizationGO:0070109.1CCL11, CCL24
7regulation of cell shapeGO:0083609.0CCL11, CCL24
8inflammatory responseGO:0069549.0CCL11, CCL24
9chemotaxisGO:0069358.9CCL24, CCL11
10positive regulation of cell migrationGO:0303358.7CCL11, CCL24
11immune responseGO:0069558.7CCL11, CCL24, PRG2

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.0CCL11, CCL24

Products for genes affiliated with Giant Papillary Conjunctivitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Giant Papillary Conjunctivitis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet