MCID: GNT006
MIFTS: 38

Giant Papillary Conjunctivitis malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Giant Papillary Conjunctivitis

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Aliases & Descriptions for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 11 46 13
Conjunctivitis, Giant Papillary 66
 
Conjunctivitis Giant Papillary 48
Gpc 46

Classifications:



External Ids:

Disease Ontology11 DOID:2457
MeSH37 D003233
SNOMED-CT60 231857004
NCIt43 C34507

Summaries for Giant Papillary Conjunctivitis

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MalaCards based summary: Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to papillary conjunctivitis and corneal deposit, and has symptoms including injection site hypersensitivity and conjunctival hyperemia. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways are IL4-mediated signaling events and Th2 Differentiation Pathway. Affiliated tissues include eye and neutrophil, and related mouse phenotype respiratory system.

Related Diseases for Giant Papillary Conjunctivitis

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Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1papillary conjunctivitis32.0CCL11, IL4
2corneal deposit30.1CXCL8, IL6
3conjunctivitis10.8
4dioctophymiasis10.5CCL11, IL4
5epididymis adenocarcinoma10.5CCL11, IL4
6bacterial gastritis10.5CCL11, IL4
7intracranial hypertension10.5CCL11, IL4
8apple allergy10.5CCL11, IL4
9cervix melanoma10.5CCL11, IL4
10central nervous system origin vertigo10.5CCL11, IL4
11pituitary hypoplasia10.5CCL11, IL4
12dacryoadenitis10.5CCL11, IL4
13gait apraxia10.5CCL11, IL4
14juvenile dermatitis herpetiformis10.4CCL11, IL4
15gonadal disease10.4CCL11, CXCL8
16melanoacanthoma10.4CCL11, IL4
17sarcoid meningitis10.4CCL11, IL4
18basidiobolomycosis10.4CXCL8, IL4
19loeffler syndrome10.4CCL11, IL4
20plantar wart10.4CXCL8, IL4
21benign fibrous mesothelioma10.4CXCL8, IL4
22benign mammary dysplasia10.3CCL11, IL6
23epidermolysis bullosa simplex superficialis10.3CSF1, IL4
24lymphocytic colitis10.3IL4, IL6
25renal cell carcinoma 410.3IL4, IL6
26scn8a encephalopathy10.3IL4, IL6
27philophthalmiasis10.3IL4, IL6
28anti-basement membrane glomerulonephritis10.3IL4, IL6
29senile cataract10.2IL4, IL6
30tarsal tunnel syndrome10.2CXCL8, IL6
31maligant granulosa cell tumor of ovary10.2CXCL8, IL6
32oesophagostomiasis10.2IL4, IL6
33gonococcal keratitis10.2IL4, IL6
34vernal conjunctivitis10.2
35benign adult familial myoclonic epilepsy10.2CXCL8, IL6
36infancy electroclinical syndrome10.2CXCL8, IL6
37autosomal dominant cerebellar ataxia10.2CXCL8, IL6
38benign lymphoepithelial lesion of salivary gland10.2IL4, IL6
39skin disease10.2CXCL8, IL6
40pasteurellosis10.2CXCL8, IL6
41subglottis neoplasm10.2CXCL8, IL6
42orbital periostitis10.2IL4, IL6
43osteogenesis imperfecta, type x10.2CXCL8, IL6
44subcorneal pustular dermatosis10.2CXCL8, IL4
45gasserian ganglion meningioma10.2CXCL8, IL6
46marchiafava bignami disease10.2CXCL8, IL6
47qualitative platelet defect10.2CXCL8, IL6
48inflammatory spondylopathy10.2CXCL8, IL6
49neurofibroma of the esophagus10.2CXCL8, IL6
50ocular cancer10.2CXCL8, IL6

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to giant papillary conjunctivitis

Symptoms for Giant Papillary Conjunctivitis

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UMLS symptoms related to Giant Papillary Conjunctivitis:


injection site hypersensitivity, conjunctival hyperemia

Drugs & Therapeutics for Giant Papillary Conjunctivitis

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Drugs for Giant Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LoteprednolPhase 44982034-46-6, 129260-79-3444025, 9865442
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
Locort
 
Loteflam
Lotemax
Lotemax (TN)
Loteprednol
Loteprednol Etabonate
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loteprednolum
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%Active, not recruitingNCT01437982Phase 4

Search NIH Clinical Center for Giant Papillary Conjunctivitis

Genetic Tests for Giant Papillary Conjunctivitis

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Anatomical Context for Giant Papillary Conjunctivitis

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MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

34
Eye, Neutrophil

Animal Models for Giant Papillary Conjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Giant Papillary Conjunctivitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5CCL11, CSF1, IL4, IL6

Publications for Giant Papillary Conjunctivitis

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Articles related to Giant Papillary Conjunctivitis:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Giant papillary conjunctivitis. (18769199)
2008
2
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. (18216583)
2008
3
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
4
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. (15677951)
2005
5
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. (14566648)
2003
6
Giant papillary conjunctivitis associated with an ocular prosthesis. (12366372)
2001
7
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
8
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. (10703125)
1999
9
Giant papillary conjunctivitis--a review. (10337425)
1999
10
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. (10444049)
1999
11
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. (9785608)
1998
12
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. (9001768)
1997
13
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. (7586473)
1995
14
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
15
Meibomian gland function and giant papillary conjunctivitis. (8420368)
1993
16
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
17
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. (1499118)
1992
18
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. (2407379)
1990
19
Giant papillary conjunctivitis associated with elevated corneal deposits. (1706653)
1990
20
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
21
Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis. (2750834)
1989
22
Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. (2917401)
1989
23
A review of contact lens induced giant papillary conjunctivitis. (3336050)
1988
24
Suprofen treatment of contact lens-associated giant papillary conjunctivitis. (3211485)
1988
25
Tear lysozyme and lactoferrin levels in giant papillary conjunctivitis and vernal conjunctivitis. (3147820)
1988
26
Giant papillary conjunctivitis associated with an extruded scleral buckle. Case report. (3619733)
1987
27
Pathology and treatment of giant papillary conjunctivitis. II. The British perspective. (3117367)
1987
28
Giant papillary conjunctivitis. (3949453)
1986
29
Giant papillary conjunctivitis. (3771999)
1986
30
Clinical management and control of giant papillary conjunctivitis secondary to contact lens wear. (3958418)
1986
31
Suture barb giant papillary conjunctivitis. (6709289)
1984
32
Giant papillary conjunctivitis following cataract extraction. (6367598)
1984
33
Giant papillary conjunctivitis in connection with corneoscleral supramid (nylon) suture knots. (6720279)
1984
34
Treatment of contact lens-induced giant papillary conjunctivitis. (6439429)
1984
35
Transient ptosis secondary to giant papillary conjunctivitis in a hydrogel lens patient. (6643895)
1983
36
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. (7234932)
1981
37
Giant papillary conjunctivitis after keratoplasty. (7008616)
1981
38
Giant papillary conjunctivitis. (7239822)
1981
39
The clinical management of giant papillary conjunctivitis. (7304717)
1981
40
Mast cell ultrastructure. Comparison in contact lens-associated giant papillary conjunctivitis and vernal conjunctivitis. (7259602)
1981
41
Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. (7236092)
1981
42
Giant papillary conjunctivitis. (6934657)
1980
43
Giant papillary conjunctivitis--a closer look. (6989883)
1980
44
Giant papillary conjunctivitis: an overview. (448014)
1979
45
Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted. (443320)
1979
46
Russell bodies in contact-lens-associated giant papillary conjunctivitis. (217320)
1979
47
Giant papillary conjunctivitis with ocular prostheses. (444123)
1979
48
Soft contact lenses from patients with giant papillary conjunctivitis. (517610)
1979
49
Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. (714378)
1978
50
Giant papillary conjunctivitis (secondary vernal) in association with contact lens wear. (285506)
1978

Variations for Giant Papillary Conjunctivitis

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Expression for genes affiliated with Giant Papillary Conjunctivitis

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Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.

Pathways for genes affiliated with Giant Papillary Conjunctivitis

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Pathways related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.6CCL11, IL4
29.6CCL11, IL4
39.4IL4, IL6
49.4IL4, IL6
59.3CXCL8, IL6
69.3CXCL8, IL6
79.3CXCL8, IL6
89.3CXCL8, IL6
99.3CXCL8, IL6
109.3CXCL8, IL6
119.3CXCL8, IL6
128.9CCL11, CXCL8, IL6
138.9CXCL8, IL4, IL6
14
Show member pathways
8.9CXCL8, IL4, IL6
158.9CXCL8, IL4, IL6
168.9CSF1, IL4, IL6
178.8CSF1, CXCL8, IL6
18
Show member pathways
8.6IL4, IL6, IL7
19
Show member pathways
8.5CCL11, CXCL8, IL4, IL6
208.1CSF1, IL4, IL6, IL7
218.1CSF1, IL4, IL6, IL7
228.1CSF1, IL4, IL6, IL7
23
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
24
Show member pathways
7.6CCL11, CXCL8, IL4, IL6, IL7
25
Show member pathways
7.1CCL11, CSF1, CXCL8, IL4, IL6, IL7
26
Show member pathways
7.1CCL11, CSF1, CXCL8, IL4, IL6, IL7
27
Show member pathways
7.1CCL11, CSF1, CXCL8, IL4, IL6, IL7
287.1CCL11, CSF1, CXCL8, IL4, IL6, IL7
29
Show member pathways
7.1CCL11, CSF1, CXCL8, IL4, IL6, IL7

GO Terms for genes affiliated with Giant Papillary Conjunctivitis

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Cellular components related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.1CCL11, CSF1, CXCL8, IL4, IL6, IL7

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1mammary duct terminal end bud growthGO:006076310.1CCL11, CSF1
2positive regulation of B cell activationGO:005087110.1IL4, IL6
3monocyte chemotaxisGO:000254810.0CCL11, IL6
4defense response to protozoanGO:004283210.0IL4, IL6
5neutrophil chemotaxisGO:00305939.9CCL11, CXCL8
6chemokine-mediated signaling pathwayGO:00700989.8CCL11, CXCL8
7branching involved in mammary gland duct morphogenesisGO:00604449.8CCL11, CSF1
8positive regulation of T cell differentiationGO:00455829.8IL4, IL7
9positive regulation of B cell proliferationGO:00308909.8IL4, IL7
10negative regulation of extrinsic apoptotic signaling pathwayGO:20012379.7IL4, IL7
11response to cytokineGO:00340979.7IL4, IL6
12homeostasis of number of cells within a tissueGO:00488739.7CSF1, IL7
13humoral immune responseGO:00069599.6IL6, IL7
14positive regulation of T cell proliferationGO:00421029.4IL4, IL6
15cellular response to interleukin-1GO:00713479.3CCL11, CXCL8, IL6
16cellular response to tumor necrosis factorGO:00713569.3CCL11, CXCL8, IL6
17chemotaxisGO:00069359.2CCL11, CXCL8, IL4
18inflammatory responseGO:00069548.6CCL11, CSF1, CXCL8, IL6
19positive regulation of cell proliferationGO:00082848.1CSF1, IL4, IL6, IL7

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.5CCL11, CXCL8
2growth factor activityGO:00080838.1CSF1, IL4, IL6, IL7
3cytokine activityGO:00051257.8CSF1, IL4, IL6, IL7

Sources for Giant Papillary Conjunctivitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet