MCID: GRD001
MIFTS: 40

Giardiasis malady

Categories: Infectious diseases

Aliases & Classifications for Giardiasis

Aliases & Descriptions for Giardiasis:

Name: Giardiasis 12 52 3 42 14 69
Infection by Giardia Lamblia 12
Beaver Feaver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10718
ICD10 33 A07.1
ICD9CM 35 007.1
MeSH 42 D005873
UMLS 69 C0017536

Summaries for Giardiasis

CDC : 3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards based summary : Giardiasis, also known as infection by giardia lamblia, is related to uveitis and malignant glioma. An important gene associated with Giardiasis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Apoptosis and Autophagy and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. The drugs Metronidazole and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia : 71 Giardiasis, popularly known as beaver fever, is a parasitic disease caused by Giardia lamblia. About 10%... more...

Related Diseases for Giardiasis

Diseases related to Giardiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
id Related Disease Score Top Affiliating Genes
1 uveitis 29.4 CD40LG CD79A
2 malignant glioma 10.3 GZMB TIA1
3 alström syndrome 10.3 GZMB TIA1
4 skeletal muscle cancer 10.3 GZMB TIA1
5 superior limbic keratoconjunctivitis 10.3 GZMB TIA1
6 collagen type iii glomerulopathy 10.3 GZMB TIA1
7 fibrosclerosis of breast 10.3 GZMB TIA1
8 uterine ligament endometrioid adenocarcinoma 10.3 GZMB TIA1
9 congenital sucrase-isomaltase deficiency with starch and lactose intolerance 10.3 GZMB TIA1
10 linear lichen planus 10.3 GZMB TIA1
11 macrogyria, pseudobulbar palsy and mental retardation 10.3 GZMB TIA1
12 malignant teratoma 10.3 GZMB TIA1
13 brown shrimp allergy 10.2 CD79A TGFB1
14 spastic diplegia 10.2 CD79A TGFB1
15 post-transplant lymphoproliferative disease 10.2 GZMB TIA1
16 plantar wart 10.2 CD79A TGFB1
17 subacute glomerulonephritis 10.2 CD79A TGFB1
18 tibial adamantinoma 10.2 CD79A GZMB TIA1
19 flat umbilicus familial 10.1 MYLK TGFB1
20 childhood immature teratoma of ovary 10.1 GZMB TIA1
21 cryptosporidiosis 10.1
22 venezuelan hemorrhagic fever 10.1 CD79A GZMB
23 alcoholic neuropathy 10.1 CD40LG CD79A
24 camptodactyly vertebral fusion 10.1 CD40LG CD79A
25 spinal polio 10.1 CD40LG CD79A
26 rabies 10.1 CD40LG CD79A
27 unilateral retinoblastoma 10.1 CD40LG CD79A
28 mesangial proliferative glomerulonephritis 10.1 CD40LG CD79A
29 delta chain disease 10.1 CD40LG CD79A
30 discitis 10.1 CD40LG CD79A
31 spinal canal and spinal cord meningioma 10.1 CD40LG CD79A
32 trichostrongyloidiasis 10.1 CD40LG CD79A
33 colloid adenoma 10.1 CD40LG CD79A
34 heart septal defect 10.1 CD40LG CD79A
35 cutaneous polyarteritis nodosa 10.1 CD40LG CD79A
36 mild pre-eclampsia 10.1 CD40LG CD79A
37 retinal microaneurysm 10.1 CD40LG CD79A
38 pediatric meningioma 10.1 CD40LG CD79A
39 tonsil cancer 10.1 CD40LG CD79A
40 indomethacin antenatal infection 10.1 CD40LG CD79A
41 postcricoid region cancer 10.1 CD40LG CD79A
42 beach ear 10.1 CD40LG CD79A
43 acute kidney tubular necrosis 10.1 CD40LG CD79A
44 atheroembolism of kidney 10.1 CD40LG CD79A
45 partial sensory epilepsy 10.1 CD40LG CD79A
46 ritscher-schinzel syndrome 1 10.1 CD40LG CD79A
47 diabetic angiopathy 10.1 CD40LG CD79A
48 endocarditis 10.1 CD40LG CD79A
49 muscular dystrophy 10.1 CD40LG CD79A
50 dumping syndrome 10.1 CD40LG CD79A

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to Giardiasis

Symptoms & Phenotypes for Giardiasis

Drugs & Therapeutics for Giardiasis

Drugs for Giardiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
2
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
3
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
4 Anti-Infective Agents Phase 4,Phase 2,Phase 3
5 Antiparasitic Agents Phase 4,Phase 2,Phase 3
6 Antiprotozoal Agents Phase 4,Phase 2
7 Anti-Bacterial Agents Phase 4,Phase 2
8 Antibiotics, Antitubercular Phase 4,Phase 2
9 Alkylating Agents Phase 4
10
Lactulose Approved Phase 2, Phase 3 4618-18-2 11333
11
Nitazoxanide Approved, Investigational, Vet_approved Phase 2, Phase 3 55981-09-4 41684
12 Gastrointestinal Agents Phase 2, Phase 3
13
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
14
Auranofin Approved Phase 2 34031-32-8 6333901 6918453
15 Liver Extracts Phase 2
16 Antirheumatic Agents Phase 2
17
Iron Approved 7439-89-6 23925
18
Formaldehyde Approved, Vet_approved 50-00-0 712
19
Methadone Approved 76-99-3 4095
20
Albendazole Approved, Vet_approved 54965-21-8 2082
21 Immunoglobulins
22 Antibodies
23 Ether
24 Secnidazole
25 Disinfectants
26 Anthelmintics
27 Antimitotic Agents

Interventional clinical trials:

(show all 13)
id Name Status NCT ID Phase
1 Giardia Induced Fatigue and Functional Gastrointestinal Diseases Completed NCT00860236 Phase 4
2 Mortality Reduction After Oral Azithromycin: Morbidity Study Recruiting NCT02048007 Phase 4
3 Treatment of Giardia Lamblia Infections in Children Not yet recruiting NCT02942485 Phase 4
4 Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy Recruiting NCT02464124 Phase 2, Phase 3
5 Auranofin Trial for GI Protozoa Recruiting NCT02736968 Phase 2
6 Optimising Antibiotic Treatment for Sick Malnourished Children Recruiting NCT02746276 Phase 2
7 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
8 Impact of Anti-Giardia and Antihelmintic Treatment on Infant Growth in Bangladesh Completed NCT00607074
9 Malabsorption as a Cause of Iron Treatment Failure in Infants Completed NCT00456729
10 Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison Completed NCT00739258
11 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
12 Normative State and Variation in Growth, Hematology, Hydration, Oxidation, Infection, Inflammation, Guatemalan Children Completed NCT02203890
13 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Giardiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: giardiasis

Genetic Tests for Giardiasis

Anatomical Context for Giardiasis

MalaCards organs/tissues related to Giardiasis:

39
Small Intestine, Testes, Pancreas, Skin, Colon, Bone, B Cells

Publications for Giardiasis

Articles related to Giardiasis:

(show top 50) (show all 570)
id Title Authors Year
1
Spontaneous Resolution of Pancreatic Cyst After Treatment for Giardiasis. ( 28085756 )
2017
2
Giardiasis Treatment Challenges in a Pediatric International Adoption Clinic. ( 28056536 )
2017
3
Foodborne giardiasis: Is there any relationship between food handlers and transmission of Giardia duodenalis? ( 28079004 )
2017
4
Giardiasis: an update review on sensitivity and specificity of methods for laboratorial diagnosis. ( 27546714 )
2016
5
Incidence rate and risk factors for giardiasis and strongyloidiasis in returning UK travellers. ( 27432907 )
2016
6
Giardiasis in NSW: Identification of Giardia duodenalis assemblages contributing to human and cattle cases, and an epidemiological assessment of sporadic human giardiasis. ( 27370572 )
2016
7
Introducing nitazoxanide as a promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in clinical isolates. ( 27633304 )
2016
8
Evolution of Socioeconomic Conditions and Its Relation to Spatial-Temporal Changes of Giardiasis and Helminthiasis in Amazonian Children. ( 27638472 )
2016
9
Postinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasis. ( 27189227 )
2016
10
Control of Giardiasis by Interleukin-17 in Humans and Mice--Are the Questions All Answered? ( 26581888 )
2016
11
An up-date on Giardia and giardiasis. ( 27501461 )
2016
12
A Prospective Longitudinal Cohort to Investigate the Effects of Early Life Giardiasis on Growth and All Cause Diarrhea. ( 27313261 )
2016
13
Demonstration of Trophozoites of G. Lamblia in Ileal Mucosal Biopsy Specimens May Reveal Giardiasis in Patients With Significantly Inflamed Parasite-free Duodenal Mucosa. ( 27186850 )
2016
14
Estimating and mapping the incidence of giardiasis in Colombia, 2009-2013. ( 27312583 )
2016
15
Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far. ( 27349189 )
2016
16
Molecular detection of giardiasis among children at Cairo University Pediatrics Hospitals. ( 27876969 )
2016
17
Giardiasis. ( 27789441 )
2016
18
Giardiasis outbreaks in the United States, 1971-2011. ( 26750152 )
2016
19
An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. ( 27864517 )
2016
20
Giardiasis in the United States - an epidemiologic and geospatial analysis of county-level drinking water and sanitation data, 1993-2010. ( 27105412 )
2016
21
Adaptive immune response in symptomatic and asymptomatic enteric protozoal infection: evidence for a determining role of parasite genetic heterogeneity in host immunity to human giardiasis. ( 27401766 )
2016
22
Contribution of environmental media to cryptosporidiosis and giardiasis prevalence in Tehran: a focus on surface waters. ( 27370533 )
2016
23
Giardiasis and Nodular Lymphoid Hyperplasia of the Duodenum. ( 27125704 )
2016
24
IMMUNOTHERAPEUTIC EFFECT OF SPIRAMYCIN IN EXPERIMENTAL GIARDIASIS. ( 27363037 )
2016
25
Chronic Giardiasis in a Case of Common Variable Immunodeficiency (CVID): A Case Report. ( 27630845 )
2016
26
Sequelae of giardiasis: an emerging public health concern. ( 27312579 )
2016
27
HUMAN GIARDIASIS IN MALAYSIA: CORRELATION BETWEEN THE PRESENCE OF CLINICAL MANIFESTATION AND GIARDIA INTESTINALIS ASSEMBLAGE. ( 26863854 )
2015
28
Terminalia ferdinandiana extracts as inhibitors of Giardia duodenalis proliferation: a new treatment for giardiasis. ( 25876047 )
2015
29
Treatment of feline giardiasis during an outbreak of diarrhoea in a cattery: potential effects on faecal Escherichia coli resistance patterns. ( 26071424 )
2015
30
Giardiasis: a malignant mimicker? ( 26055831 )
2015
31
Chloroquine: An Old Drug with New Perspective Against Giardiasis. ( 26365362 )
2015
32
A bibliometric study of international scientific productivity in giardiasis covering the period 1971-2010. ( 25596575 )
2015
33
Investigation of Volatile Organic Compounds Emitted from Faeces for the Diagnosis of Giardiasis. ( 26405699 )
2015
34
Perceived food intolerance and irritable bowel syndrome in a population 3A years after a giardiasis-outbreak: a historical cohort study. ( 26585714 )
2015
35
Immune reconstitution syndrome in a human immunodeficiency virus infected child due to giardiasis leading to shock. ( 26985424 )
2015
36
A comparison of exposure to risk factors for giardiasis in non-travellers, domestic travellers and international travellers in a Canadian community, 2006-2012. ( 26419277 )
2015
37
Determination of Giardia duodenalis assemblages and multi-locus genotypes in patients with sporadic giardiasis from England. ( 26338670 )
2015
38
Evaluation of ImmunoCard STAT test and ELISA versus light microscopy in diagnosis of giardiasis and cryptosporidiosis. ( 25924795 )
2015
39
Increased incidence of nitroimidazole-refractory giardiasis at the Hospital for Tropical Diseases, London: 2008-2013. ( 25975511 )
2015
40
Giardiasis surveillance -- United States, 2011-2012. ( 25928582 )
2015
41
Case-Control Study of Risk Factors for Sporadic Giardiasis and Parasite Assemblages in North West England. ( 26157151 )
2015
42
Refractory giardiasis in renal transplantation: a case report. ( 25535868 )
2015
43
Paediatrician and Caregiver Awareness of Cryptosporidiosis and Giardiasis in Children: US Survey Responses. ( 26685056 )
2015
44
Refractory giardiasis: A molecular appraisal from a tertiary care centre in India. ( 25297020 )
2014
45
A family cluster of giardiasis with variable treatment responses: refractory giardiasis in a family after a trip to India. ( 23926944 )
2014
46
Ginger and cinnamon: can this household remedy treat giardiasis? Parasitological and histopathological studies. ( 25759734 )
2014
47
Clinical and diagnostic features and treatment of giardiasis. ( 25541827 )
2014
48
Diffuse nodular lymphoid hyperplasia of the small bowel associated with common variable immunodeficiency and giardiasis: a rare case report. ( 24647448 )
2014
49
A case report of strongyloidiasis associated with giardiasis in a patient with renal calculi from a tertiary care center in South India. ( 25191059 )
2014
50
Resistance to reinfection in mice as a vaccine model for giardiasis. ( 24805818 )
2014

Variations for Giardiasis

Expression for Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for Giardiasis

Pathways related to Giardiasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.06 CD40LG GZMB TIA1
2
Show member pathways
10.76 GZMB TGFB1
3 10.52 CD40LG CD79A

GO Terms for Giardiasis

Biological processes related to Giardiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glycolytic process GO:0006096 9.16 ENO1 TPI1
2 B cell proliferation GO:0042100 8.96 CD40LG CD79A
3 canonical glycolysis GO:0061621 8.62 ENO1 TPI1

Sources for Giardiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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