Aliases & Classifications for Giardiasis

MalaCards integrated aliases for Giardiasis:

Name: Giardiasis 12 52 3 42 14 69
Infection by Giardia Lamblia 12
Beaver Feaver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10718
ICD10 33 A07.1
ICD9CM 35 007.1
MeSH 42 D005873
UMLS 69 C0017536

Summaries for Giardiasis

CDC : 3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards based summary : Giardiasis, also known as infection by giardia lamblia, is related to uveitis and hypoglycemia. An important gene associated with Giardiasis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Apoptosis and Autophagy and Primary immunodeficiency. The drugs Metronidazole and Tinidazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia : 72 Giardiasis, popularly known as beaver fever, is a parasitic disease caused by Giardia lamblia. About 10%... more...

Related Diseases for Giardiasis

Diseases related to Giardiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
id Related Disease Score Top Affiliating Genes
1 uveitis 29.6 CD40LG CD79A
2 hypoglycemia 10.7 GZMB TIA1
3 male infertility 10.7 GZMB TIA1
4 succinic acidemia lactic acidosis congenital 10.7 GZMB TIA1
5 rubella panencephalitis 10.7 GZMB TIA1
6 gastrointestinal tuberculosis 10.6 GZMB TIA1
7 congenital sucrase-isomaltase deficiency with starch intolerance 10.6 GZMB TIA1
8 breast fibroadenosis 10.6 GZMB TIA1
9 pediatric lymphoma 10.6 GZMB TIA1
10 testicular germ cell cancer 10.6 GZMB TIA1
11 macrocephaly, mental retardation, short stature, spastic paraplegia and cns malformations 10.6 GZMB TIA1
12 cholesteatoma of middle ear 10.6 CD79A TGFB1
13 plantar wart 10.6 CD79A TGFB1
14 focal embolic glomerulonephritis 10.6 CD79A TGFB1
15 polycystic ovary syndrome 10.6 GZMB TIA1
16 mucinous intrahepatic cholangiocarcinoma 10.6 GZMB TIA1
17 plasmodium ovale malaria 10.6 GZMB TIA1
18 bolivian hemorrhagic fever 10.6 CD79A GZMB
19 fibular aplasia ectrodactyly 10.5 MYLK TGFB1
20 mixed cell type cancer 10.5 GZMB TIA1
21 cholera 10.5 CD79A TGFB1
22 loiasis 10.4 CD79A TGFB1
23 epidermolysis bullosa simplex superficialis 10.4 CD79A TGFB1
24 clivus chondroid chordoma 10.4 CD79A GZMB TIA1
25 screw worm infectious disease 10.3 GZMB TGFB1
26 alcoholic neuropathy 10.3 CD40LG CD79A
27 calloso-genital dysplasia 10.3 CD40LG CD79A
28 variola major 10.3 CD40LG CD79A
29 mu chain disease 10.3 CD40LG CD79A
30 rabies 10.3 CD40LG CD79A
31 familial retinoblastoma 10.3 CD40LG CD79A
32 anti-basement membrane glomerulonephritis 10.3 CD40LG CD79A
33 microinvasive cervical squamous cell carcinoma 10.3 CD40LG CD79A
34 fetal erythroblastosis 10.3 CD40LG CD79A
35 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
36 trichostrongyloidiasis 10.3 CD40LG CD79A
37 leukodystrophy 10.3 CD40LG CD79A
38 retinal microaneurysm 10.3 CD40LG CD79A
39 heart septal defect 10.3 CD40LG CD79A
40 cryptorchidism arachnodactyly mental retardation 10.3 CD40LG CD79A
41 acute kidney tubular necrosis 10.3 CD40LG CD79A
42 secretory meningioma 10.3 CD40LG CD79A
43 hodgkin's lymphoma, nodular sclerosis 10.3 CD40LG CD79A
44 imperforate oropharynx-costo vetebral anomalies 10.3 CD40LG CD79A
45 malignant otitis externa 10.3 CD40LG CD79A
46 transient hypogammaglobulinemia 10.3 CD40LG CD79A
47 benign epilepsy with centrotemporal spikes 10.3 CD40LG CD79A
48 tongue cancer 10.3 CD40LG CD79A
49 hydrops of gallbladder 10.3 CD40LG CD79A
50 gamma heavy chain disease 10.3 CD40LG CD79A

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to Giardiasis

Symptoms & Phenotypes for Giardiasis

Drugs & Therapeutics for Giardiasis

Drugs for Giardiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
2
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
3
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
4 Anti-Infective Agents Phase 4,Phase 2,Phase 3
5 Antiparasitic Agents Phase 4,Phase 2,Phase 3
6 Antiprotozoal Agents Phase 4,Phase 2
7 Alkylating Agents Phase 4
8 Anti-Bacterial Agents Phase 4,Phase 2
9 Antibiotics, Antitubercular Phase 4,Phase 2
10
Lactulose Approved Phase 2, Phase 3 4618-18-2 11333
11
Nitazoxanide Approved, Investigational, Vet_approved Phase 2, Phase 3 55981-09-4 41684
12 Gastrointestinal Agents Phase 2, Phase 3
13
Auranofin Approved Phase 2 34031-32-8 6333901 6918453
14
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
15 Antirheumatic Agents Phase 2
16 Liver Extracts Phase 2
17
Albendazole Approved, Vet_approved 54965-21-8 2082
18
Secnidazole Approved 3366-95-8
19
Iron Approved 7439-89-6 23925
20
Methadone Approved 76-99-3 4095
21
Formaldehyde Approved, Vet_approved 50-00-0 712
22 Antibodies
23 Immunoglobulins
24 Anthelmintics
25 Antimitotic Agents
26 Disinfectants
27 Ether

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 Giardia Induced Fatigue and Functional Gastrointestinal Diseases Completed NCT00860236 Phase 4
2 Treatment of Giardia Lamblia Infections in Children Recruiting NCT02942485 Phase 4 Metronidazole;Tinidazole
3 Mortality Reduction After Oral Azithromycin: Morbidity Study Recruiting NCT02048007 Phase 4 Azithromycin;Placebo
4 Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy Recruiting NCT02464124 Phase 2, Phase 3 Nitazoxanide;Lactulose
5 Auranofin Trial for GI Protozoa Recruiting NCT02736968 Phase 2 Auranofin
6 Optimising Antibiotic Treatment for Sick Malnourished Children Active, not recruiting NCT02746276 Phase 2 Ceftriaxone;Metronidazole
7 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
8 Impact of Anti-Giardia and Antihelmintic Treatment on Infant Growth in Bangladesh Completed NCT00607074 Anti-Giardia and antihelmintic treatment (secnidazole or albendazole);Anti-Giardia treatment only (secnidazole or albendazole);Control group (placebo)
9 Malabsorption as a Cause of Iron Treatment Failure in Infants Completed NCT00456729 Metronidazole
10 Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison Completed NCT00739258
11 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
12 Normative State and Variation in Growth, Hematology, Hydration, Oxidation, Infection, Inflammation, Guatemalan Children Completed NCT02203890
13 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
14 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Giardiasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: giardiasis

Genetic Tests for Giardiasis

Anatomical Context for Giardiasis

MalaCards organs/tissues related to Giardiasis:

39
Small Intestine, Testes, Liver, Pancreas, Skin, Colon, Bone

Publications for Giardiasis

Articles related to Giardiasis:

(show top 50) (show all 585)
id Title Authors Year
1
Spontaneous Resolution of Pancreatic Cyst After Treatment for Giardiasis. ( 28085756 )
2017
2
A novel inA vitro image-based assay identifies new drug leads for giardiasis. ( 28171818 )
2017
3
Giardiasis Diagnosis and Treatment Practices Among Commercially Insured Persons in the United States. ( 28207070 )
2017
4
Incidental giardiasis diagnosed during transduodenal EUS-FNA. ( 28713065 )
2017
5
Foodborne giardiasis: Is there any relationship between food handlers and transmission of Giardia duodenalis? ( 28079004 )
2017
6
Nitroimidazole-refractory giardiasis: a growing problem requiring rational solutions. ( 28624613 )
2017
7
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome. ( 28129747 )
2017
8
Giardiasis Outbreak Associated with Asymptomatic Food Handlers in New York State, 2015. ( 28402185 )
2017
9
The influence of serial fecal sampling on the diagnosis of giardiasis in humans, dogs, and cats. ( 28902297 )
2017
10
Under-reporting giardiasis: time to consider the public health implications. ( 28879824 )
2017
11
Significance of Nitric Oxide Level in Giardiasis. ( 28164484 )
2017
12
Giardiasis Treatment Challenges in a Pediatric International Adoption Clinic. ( 28056536 )
2017
13
Diffuse Nodular Lymphoid Hyperplasia of the Intestine Caused by Common Variable Immunodeficiency and Refractory Giardiasis. ( 28154271 )
2017
14
Giardiasis and Subsequent Irritable Bowel Syndrome: A Longitudinal Cohort Study Using Health Insurance Data. ( 28329069 )
2017
15
Stimulated and Unstimulated Saliva Levels of Calcium and Magnesium in Giardiasis. ( 28111708 )
2017
16
Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis. ( 28842650 )
2017
17
The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis. ( 28830665 )
2017
18
Giardiasis and Nodular Lymphoid Hyperplasia of the Duodenum. ( 27125704 )
2016
19
Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far. ( 27349189 )
2016
20
Control of Giardiasis by Interleukin-17 in Humans and Mice--Are the Questions All Answered? ( 26581888 )
2016
21
Giardiasis in NSW: Identification of Giardia duodenalis assemblages contributing to human and cattle cases, and an epidemiological assessment of sporadic human giardiasis. ( 27370572 )
2016
22
Estimating and mapping the incidence of giardiasis in Colombia, 2009-2013. ( 27312583 )
2016
23
Giardiasis: an update review on sensitivity and specificity of methods for laboratorial diagnosis. ( 27546714 )
2016
24
Giardiasis in the United States - an epidemiologic and geospatial analysis of county-level drinking water and sanitation data, 1993-2010. ( 27105412 )
2016
25
Demonstration of Trophozoites of G. Lamblia in Ileal Mucosal Biopsy Specimens May Reveal Giardiasis in Patients With Significantly Inflamed Parasite-free Duodenal Mucosa. ( 27186850 )
2016
26
Adaptive immune response in symptomatic and asymptomatic enteric protozoal infection: evidence for a determining role of parasite genetic heterogeneity in host immunity to human giardiasis. ( 27401766 )
2016
27
Contribution of environmental media to cryptosporidiosis and giardiasis prevalence in Tehran: a focus on surface waters. ( 27370533 )
2016
28
Giardiasis outbreaks in the United States, 1971-2011. ( 26750152 )
2016
29
An up-date on Giardia and giardiasis. ( 27501461 )
2016
30
Giardiasis. ( 27789441 )
2016
31
IMMUNOTHERAPEUTIC EFFECT OF SPIRAMYCIN IN EXPERIMENTAL GIARDIASIS. ( 27363037 )
2016
32
A Prospective Longitudinal Cohort to Investigate the Effects of Early Life Giardiasis on Growth and All Cause Diarrhea. ( 27313261 )
2016
33
Molecular detection of giardiasis among children at Cairo University Pediatrics Hospitals. ( 27876969 )
2016
34
Postinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasis. ( 27189227 )
2016
35
Sequelae of giardiasis: an emerging public health concern. ( 27312579 )
2016
36
Chronic Giardiasis in a Case of Common Variable Immunodeficiency (CVID): A Case Report. ( 27630845 )
2016
37
Evolution of Socioeconomic Conditions and Its Relation to Spatial-Temporal Changes of Giardiasis and Helminthiasis in Amazonian Children. ( 27638472 )
2016
38
Incidence rate and risk factors for giardiasis and strongyloidiasis in returning UK travellers. ( 27432907 )
2016
39
An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. ( 27864517 )
2016
40
Introducing nitazoxanide as a promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in clinical isolates. ( 27633304 )
2016
41
Giardiasis: a malignant mimicker? ( 26055831 )
2015
42
Perceived food intolerance and irritable bowel syndrome in a population 3A years after a giardiasis-outbreak: a historical cohort study. ( 26585714 )
2015
43
Terminalia ferdinandiana extracts as inhibitors of Giardia duodenalis proliferation: a new treatment for giardiasis. ( 25876047 )
2015
44
Immune reconstitution syndrome in a human immunodeficiency virus infected child due to giardiasis leading to shock. ( 26985424 )
2015
45
Investigation of Volatile Organic Compounds Emitted from Faeces for the Diagnosis of Giardiasis. ( 26405699 )
2015
46
Chloroquine: An Old Drug with New Perspective Against Giardiasis. ( 26365362 )
2015
47
Paediatrician and Caregiver Awareness of Cryptosporidiosis and Giardiasis in Children: US Survey Responses. ( 26685056 )
2015
48
Evaluation of ImmunoCard STAT test and ELISA versus light microscopy in diagnosis of giardiasis and cryptosporidiosis. ( 25924795 )
2015
49
A bibliometric study of international scientific productivity in giardiasis covering the period 1971-2010. ( 25596575 )
2015
50
Case-Control Study of Risk Factors for Sporadic Giardiasis and Parasite Assemblages in North West England. ( 26157151 )
2015

Variations for Giardiasis

Expression for Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for Giardiasis

Pathways related to Giardiasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.06 CD40LG GZMB TIA1
2 10.72 CD40LG CD79A
3
Show member pathways
10.56 GZMB TGFB1

GO Terms for Giardiasis

Biological processes related to Giardiasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glycolytic process GO:0006096 9.16 ENO1 TPI1
2 B cell proliferation GO:0042100 8.96 CD40LG CD79A
3 canonical glycolysis GO:0061621 8.62 ENO1 TPI1

Sources for Giardiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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