MCID: GRD001
MIFTS: 51

Giardiasis malady

Infectious category

Summaries for Giardiasis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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CDC:3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards: Giardiasis, also known as infection by giardia lamblia, is related to deficiency anemia and celiac disease. An important gene associated with Giardiasis is TPI1 (triosephosphate isomerase 1), and among its related pathways are Fructose catabolism and Glucose metabolism. The drugs albendazole and metronidazole and the compounds 2-phosphoglycerate and 3-phosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone marrow, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite giardia intestinalis. the symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia:64 Giardiasis (popularly known as beaver fever) is a parasitic disease caused by the flagellate protozoan... more...

Aliases & Classifications for Giardiasis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

giardiasis 8 10 45 61
infection by giardia lamblia 8
beaver feaver 8


External Ids:

Disease Ontology8 DOID:10718
ICD9CM27 007.1
MeSH35 D005873
ICD1025 A07.1

Related Diseases for Giardiasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Giardiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1deficiency anemia30.2CD79A, TPI1
2celiac disease30.2GZMB, LCT, CD79A
3lactose intolerance30.0LCT
4irritable bowel syndrome30.0LCT
5urticaria30.0GZMB
6hepatitis c29.8ENO1, DNAH8
7cystic fibrosis29.8OTC, SI, DNAH8, TREH, SCT
8cryptosporidiosis10.5
9amebiasis10.3
10ascariasis10.2
11helminthiasis10.2
12h. pylori infection10.2
13trichomoniasis10.1
14iron deficiency anemia10.1
15protein-losing enteropathy10.1
16chronic fatigue syndrome10.1
17common variable immunodeficiency10.1
18duodenitis10.1
19n syndrome10.1
20agammaglobulinemia10.1
21immunoglobulin g deficiency10.1
22thrombocytopenia10.0CD79A
23duodenal ulcer10.0SCT
24prostatitis10.0CD79A
25interstitial lung disease10.0CD79A
26thyroiditis10.0CD79A
27sarcoidosis10.0GZMB
28alopecia areata10.0GZMB
29schistosomiasis10.0CD79A
30zollinger-ellison syndrome10.0SCT
31epidermolysis bullosa acquisita10.0CD79A
32exanthem10.0CD79A
33lung cancer10.0TGFB1
34infectious mononucleosis10.0CD79A, TPI1
35exocrine pancreatic insufficiency10.0SCT
36pulmonary disease, chronic obstructive10.0TGFB1
37inflammatory bowel disease10.0CD79A, TGFB1
38pneumonia10.0CD79A, TGFB1
39glomerulonephritis10.0TGFB1, CD79A
40pancreatitis10.0TGFB1, SCT
41eye disease10.0TGFB1
42hypothyroidism10.0DNAH8
43skin disease10.0TGFB1, GZMB
44hepatitis10.0GZMB, OTC, TPI1
45gingivitis10.0SI
46myopathy10.0TPI1, DNAH8
47tuberculosis10.0TPI1, ENO1, CD79A, GZMB
48primary biliary cirrhosis10.0ENO1, CD79A, GZMB, SCT
49glucose intolerance10.0CD79A, LCT, SI
50peptic ulcer10.0DNAH8, SCT

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to giardiasis

Clinical Features for Giardiasis

Drugs & Therapeutics for Giardiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Giardiasis

Drug clinical trials:

Search ClinicalTrials for Giardiasis

Search NIH Clinical Center for Giardiasis

Search CenterWatch for Giardiasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Giardiasis

Anatomical Context for Giardiasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Giardiasis:

33
Skin, Liver, Bone marrow, Smooth muscle, Small intestine, Colon, Pancreas, Thyroid, Breast, T cells, B cells

Animal Models for Giardiasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Giardiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3TGFB1, TPI1, OTC, CD79A, MYLK, TREH

Publications for Giardiasis

Sources:
51PubMed
See all sources

Articles related to Giardiasis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
An adolescent with chronic giardiasis mimicking anorexia nervosa. (23893673)
2013
2
Bullous eosinophilic cellulitis associated with giardiasis. (23879549)
2013
3
Infection: Modelling persistent giardiasis and malnutrition. (23752824)
2013
4
Giardiasis revisited: an underappreciated reemerging zoonotic disease. (23055462)
2012
5
Albendazole versus metronidazole in the treatment of adult giardiasis: a randomized, double-blind, clinical trial. (22114904)
2012
6
Occurrence of bovine giardiasis and endemic genetic characterization of Giardia duodenalis isolates in Heilongjiang Province, in the Northeast of China. (22398834)
2012
7
Secnidazole for the treatment of giardiasis in naturally infected cats. (21763779)
2011
8
Giardiasis as zoonosis: between proof of principle and paradigm in the Northwestern region of SALo Paulo State, Brazil. (21861011)
2011
9
Cryptosporidiosis and giardiasis in dogs and cats: veterinary and public health importance. (19545532)
2010
10
Giardiasis--why do the symptoms sometimes never stop? (20056486)
2010
11
Gene polymorphism in transforming growth factor-beta codon 10 is associated with susceptibility to Giardiasis. (19703231)
2009
12
Use of a non-mercury containing fixative for diagnosis of giardiasis. (19143121)
2008
13
Prevalence and risk factors for giardiasis among primary school children in Damascus, Syria. (18246233)
2008
14
Cholangiopathy associated with giardiasis in a patient with human immunodeficiency virus infection. (18223486)
2008
15
Characterization of the local immune response to cyst antigens during the acute and elimination phases of primary murine giardiasis. (18037419)
2008
16
Relationship between the rate of giardiasis and knowledge and practice of prevention in primary school children in south of Tehran. (18773223)
2008
17
Influence of the antioxidant drug (Antox) on experimental giardiasis and microsporidiosis. (17580577)
2007
18
Prolonged outbreak of giardiasis with two modes of transmission. (16569269)
2006
19
Determinants of the geographical distribution of endemic giardiasis in Ontario, Canada: a spatial modelling approach. (15473161)
2004
20
Albendazole versus metronidazole treatment of adult giardiasis: An open randomized clinical study. (15069729)
2004
21
Investigation of clusters of giardiasis using GIS and a spatial scan statistic. (15176979)
2004
22
Genotyping of human giardiasis in relation to anti-Giardia secretory IgA and mucosal histopathology. (15287171)
2004
23
Whipple disease associated with giardiasis. (12964113)
2003
24
Incidence of giardiasis among siblings in Turkey. (12828587)
2003
25
The histo-pathology of human giardiasis. (14708859)
2003
26
Duodenal nodular lymphoid hyperplasia caused by giardiasis infection in a patient who is immunodeficient. (11923787)
2002
27
Establishment of a C57BL/6N mouse model of giardiasis. (12490085)
2002
28
Comparative study on ELISA, IFA and direct methods in diagnosis of giardiasis. (12214916)
2002
29
Neuroblastoma with concomitant giardiasis: report of a case with diagnosis by fine needle aspiration cytology. (11575653)
2001
30
Diagnostic advantages and therapeutic options for giardiasis. (11772266)
2001
31
Comparative clinical trial of mebendazole and metronidazole in giardiasis of children. (11419683)
2001
32
Drugs for treating giardiasis. (10796511)
2000
33
Giardiasis in pinnipeds from eastern Canada. (10574540)
1999
34
A study on the relation between proton pump inhibitor and gastric giardiasis. (9617051)
1998
35
Effect of salinomycin on giardiasis and coccidiosis in growing lambs. (8994902)
1996
36
Prevalence of giardiasis among Malaysian primary school children. (10968037)
1996
37
Comparison of mebendazole with metronidazole and furazolidone in the treatment of Giardiasis in children. (17589007)
1995
38
Giardiasis as a threat to backpackers in the United States: a survey of state health departments. (11995903)
1995
39
Treating possible giardiasis. (8304864)
1993
40
Serodiagnosis of giardiasis by counterimmunoelectrophoresis and indirect immunofluorescence tests. (8308334)
1993
41
Suburban dogs--a reservoir of human giardiasis? (1630360)
1992
42
Giardiasis and amoebiasis infections in three Saudi closed communities. (1995937)
1991
43
Giardiasis, cryofibrinogenemia, and cold sensitivity: a response to metronidazole. (1938062)
1991
44
Enzyme-linked immunosorbent assay for copro-diagnosis of giardiasis and characterisation of a specific Giardia lamblia antigen in stools. (2030502)
1991
45
Endemic giardiasis and municipal water supply. (2029049)
1991
46
Copper deficiency in an infant with giardiasis fed with cow's milk. (2380028)
1990
47
The diagnosis of childhood giardiasis. (2303985)
1990
48
Canine giardiasis in Sweden: no evidence of infectivity to man. (2389317)
1990
49
Is giardiasis a zoonosis? (2076071)
1990
50
Nitro-imidazole in protozoal infections (amoebiasis, giardiasis and trichomoniasis). (5357261)
1969

Genetic Variations for Giardiasis

Expression for genes affiliated with Giardiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for genes affiliated with Giardiasis

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Giardiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3SI, ALDOC
2
Hide members
9.2TPI1, ALDOC, ENO1
39.1SI, TREH, LCT
4
Hide members
8.8OTC, ENO1, ALDOC, TPI1
5
Hide members
8.5TPI1, ALDOC, ENO1, OTC, SI
6
Hide members
7.8TPI1, LCT, TREH, SI, ENO1, ALDOC

Compounds for genes affiliated with Giardiasis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 11DrugBank
See all sources

Compounds related to Giardiasis according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
12-phosphoglycerate4510.4TPI1, ENO1
23-phosphoglycerate4510.3TPI1, ENO1
3pneumococcal4510.2ENO1, CD79A
4lactulose4510.1CD79A, SI
5butyrate4510.1OTC, SI
6phlorizin45 29 6012.0SI, LCT
7oxygen45 2411.0SI
8gliadin4510.0SI, CD79A
9ramipril45 1110.9TGFB1, CD79A
102,3-butanedione monoxime459.9DNAH8, MYLK
11phosphoenolpyruvate45 1110.9SI, OTC, ENO1
12malate459.8TPI1, OTC, DNAH8
13scopolamine45 29 11 2412.7SI, DNAH8
14pmma459.7TGFB1, CD79A
15carnitine459.7OTC, CD79A, DNAH8
16pyruvate459.7SI, OTC, ENO1, TPI1
17prednisolone45 29 1111.6GZMB, DNAH8, CD79A
18glutaraldehyde459.6TGFB1, CD79A, DNAH8
19estrogen459.6SI, CD79A
20clonidine45 29 1111.5SCT, DNAH8, TGFB1
21theophylline45 29 11 2412.5TGFB1, CD79A, DNAH8
224-hydroxynonenal45 2410.5DNAH8, ENO1, TGFB1
23hyaluronic acid45 2410.5GZMB, CD79A, TGFB1
24fatty acid459.5SI, OTC, ENO1, TPI1
25thyroxine45 2410.3SCT, DNAH8, CD79A, TGFB1
26paraffin459.3GZMB, CD79A, SI, TGFB1
27indomethacin45 60 29 1112.3SCT, DNAH8, CD79A, TGFB1
28carbon459.3TPI1, SI, TREH
29glycerol45 11 2411.2LCT, DNAH8, CD79A, OTC, TPI1
30polysaccharide459.1DNAH8, CD79A, SI, TGFB1
31cyclosporin a45 29 6011.0GZMB, SCT, DNAH8, CD79A, TGFB1
32creatinine458.8DNAH8, CD79A, OTC, ENO1, TPI1, TGFB1
33aspartate458.8TPI1, SCT, MYLK, DNAH8, SI, OTC
34lipid458.8LCT, GZMB, SCT, SI, OTC, ENO1
35retinoic acid45 249.7GZMB, SCT, DNAH8, CD79A, ENO1, TGFB1
36lactate458.7GZMB, CD79A, SI, OTC, ENO1, TPI1
37glutamine458.6SCT, DNAH8, SI, OTC, ENO1, TGFB1
38arginine458.6GZMB, SCT, DNAH8, CD79A, SI, OTC
39atp45 299.6GZMB, SCT, MYLK, DNAH8, OTC, ENO1
40hydrogen45 249.5LCT, SCT, TREH, DNAH8, SI, TPI1
41cysteine458.4LCT, GZMB, SCT, DNAH8, CD79A, SI
42glutamate458.4GZMB, SCT, MYLK, DNAH8, CD79A, OTC
43alanine457.9GZMB, TREH, MYLK, DNAH8, CD79A, SI
44glucose457.8LCT, GZMB, SCT, TREH, MYLK, SI

GO Terms for genes affiliated with Giardiasis

Sources:
16Gene Ontology
See all sources

Biological processes related to Giardiasis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1polysaccharide digestionGO:0442459.3SI, TREH, LCT
2gluconeogenesisGO:0060949.2TPI1, ALDOC, ENO1
3glycolysisGO:0060969.2ENO1, ALDOC, TPI1
4positive regulation of cell migrationGO:0303359.1TGFB1, MYLK, SYNE2
5glucose metabolic processGO:0060068.9TPI1, ALDOC, ENO1
6carbohydrate metabolic processGO:0059757.9LCT, TREH, SI, ENO1, ALDOC, TPI1
7small molecule metabolic processGO:0442817.4LCT, TREH, SI, OTC, ENO1, ALDOC

Products for genes affiliated with Giardiasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Giardiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet