MCID: GRD001
MIFTS: 55

Giardiasis malady

Infectious diseases category

Summaries for Giardiasis

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CDC:4 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards based summary: Giardiasis, also known as infection by giardia lamblia, is related to diarrhea and celiac disease. An important gene associated with Giardiasis is TPI1 (triosephosphate isomerase 1), and among its related pathways are Glucose metabolism and MPS VI - Maroteaux-Lamy syndrome. The drugs metronidazole and metronidazole hydrochloride and the compounds 2-phosphoglycerate and 3-phosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:10 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite giardia intestinalis. the symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia:65 Giardiasis (popularly known as beaver fever) is a zoonotic parasitic disease caused by the flagellate... more...

Aliases & Classifications for Giardiasis

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 4CDC, 62UMLS, 57SNOMED-CT, 29ICD9CM, 35MeSH, 27ICD10
See all sources

Giardiasis, Aliases & Descriptions:

Name: Giardiasis 10 12 45 4 62
Infection by Giardia Lamblia 10 62
 
Beaver Feaver 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology10 DOID:10718
ICD9CM29 007.1
MeSH35 D005873
ICD1027 A07.1

Related Diseases for Giardiasis

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Diseases related to Giardiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.4LCT, CD79A
2celiac disease30.3CD79A, GZMB, LCT
3pancreatic cancer30.1SCT, TGFB1, ENO1
4lactose intolerance30.0LCT
5hepatitis29.9TGFB1, GZMB
6inflammatory bowel disease29.9CD79A, TGFB1
7cystic fibrosis29.9DNAH8, SCT
8leukemia29.8TGFB1, DNAH8, GZMB, ENO1, CD79A
9cryptosporidiosis10.5
10duodenitis10.5
11amebiasis10.3
12ascariasis10.2
13deficiency anemia10.2
14common variable immunodeficiency10.2
15trichomoniasis10.2
16iron deficiency anemia10.2
17pancreatitis10.2
18protein-losing enteropathy10.1
19chronic fatigue syndrome10.1
20irritable bowel syndrome10.1
21agammaglobulinemia10.1
22hypothyroidism10.1
23intestinal disease10.1
24urticaria10.1
25exanthem10.1CD79A
26epidermolysis bullosa acquisita10.1CD79A
27exocrine pancreatic insufficiency10.1SCT
28zollinger-ellison syndrome10.1SCT
29pfeiffer syndrome10.0TPI1, CD79A
30measles10.0CD79A, SCT
31glucose intolerance10.0LCT, CD79A
32lupus nephritis10.0TGFB1, CD79A
33glomerulosclerosis10.0CD79A, TGFB1
34iga glomerulonephritis10.0TGFB1, CD79A
35connective tissue disease10.0TGFB1, CD79A
36skin disease10.0TGFB1, GZMB
37sjogren's syndrome10.0CD79A, GZMB
38systemic lupus erythematosus10.0CD79A, ENO1, TPI1
39ulcerative colitis10.0CD79A, ENO1, GZMB
40vasculitis10.0CD79A, ENO1
41intrahepatic cholestasis10.0DNAH8, SCT
42gastroesophageal reflux10.0DNAH8, SCT
43peptic ulcer disease10.0DNAH8, SCT
44pancreatitis, hereditary10.0TGFB1, SCT
45tuberculosis10.0TPI1, GZMB, ENO1, CD79A
46dermatitis10.0CD79A, GZMB
47primary biliary cirrhosis10.0SCT, GZMB, ENO1, CD79A
48gastritis10.0SCT, DNAH8, CD79A
49herpes simplex10.0DNAH8, ENO1, CD79A
50influenza10.0DNAH8, GZMB, CD79A

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to giardiasis

Symptoms for Giardiasis

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Drugs & Therapeutics for Giardiasis

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Drug clinical trials:

Search ClinicalTrials for Giardiasis

Search NIH Clinical Center for Giardiasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Giardiasis

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Anatomical Context for Giardiasis

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MalaCards organs/tissues related to Giardiasis:

33
Small intestine, Testes, Pancreas, Colon, Skin, Bone marrow, Bone, Smooth muscle, Liver, Thyroid, Breast, T cells, B cells

Animal Models for Giardiasis or affiliated genes

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MGI Mouse Phenotypes related to Giardiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.9CD79A, GZMB, MYLK, TGFB1, TPI1
2MP:00053767.2CD79A, SCT, TPI1, TGFB1, MYLK, GZMB

Publications for Giardiasis

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Articles related to Giardiasis:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Resistance to reinfection in mice as a vaccine model for giardiasis. (24805818)
2014
2
Giardiasis in a patient undergoing chemotherapy for retinoblastoma and acute myelogenous leukemia. (23910805)
2013
3
Secnidazole for the treatment of giardiasis in naturally infected cats. (21763779)
2011
4
Mebendazole compared with secnidazole in the treatment of adult giardiasis: a randomised, no-inferiority, open clinical trial. (22174992)
2011
5
Risk factors for endemic giardiasis: highlighting the possible association of contaminated water and food. (18377940)
2008
6
Survey of feline giardiasis by ELISA test in Italy. (17195926)
2007
7
Investigation of potential zooanthroponotic transmission of cryptosporidiosis and giardiasis through agricultural use of reclaimed wastewater. (17164167)
2006
8
Risk of giardiasis associated with water supply in an endemic context. (16990176)
2006
9
Giardiasis surveillance--United States, 1998-2002. (15674189)
2005
10
Determinants of the geographical distribution of endemic giardiasis in Ontario, Canada: a spatial modelling approach. (15473161)
2004
11
Albendazole as an alternative therapeutic agent for childhood giardiasis in Turkey. (15191380)
2004
12
Prevalence of Giardiasis due to wastewater reuse for agriculture in the suburbs of Asmara City, Eritrea. (14660117)
2004
13
Antitransglutaminase antibodies and giardiasis. (15571608)
2004
14
Symptomatic giardiasis without diarrhea: further evidence to support the routine duodenal biopsy? (12838238)
2003
15
Geographical and temporal distribution of human giardiasis in Ontario, Canada. (12946275)
2003
16
Giardiasis treatment in Turkish children with a single dose of ornidazole. (12587625)
2002
17
Risk of giardiasis in Aucklanders: a case-control study. (12718834)
2002
18
Neuroblastoma with concomitant giardiasis: report of a case with diagnosis by fine needle aspiration cytology. (11575653)
2001
19
Giardiasis-associated arthralgia in children. (11471528)
2001
20
Serum vitamin A and beta-carotene levels in children with giardiasis before and after treatment. (9718915)
1998
21
Efficacy of a drug combination of praziquantel, pyrantel pamoate, and febantel against giardiasis in dogs. (9736391)
1998
22
A study on the relation between proton pump inhibitor and gastric giardiasis. (9617051)
1998
23
Efficacy of fenbendazole for treatment of giardiasis in calves. (9099384)
1997
24
Case in point. Small bowel giardiasis. (9307595)
1997
25
Symptoms in patients with giardiasis undergoing upper gastrointestinal endoscopy. (9427489)
1997
26
Intestinal lymphangiectasia due to recurrent giardiasis. (8607534)
1996
27
Single-dose secnidazole versus 10-day metronidazole therapy of giardiasis in Iranian children. (8699592)
1996
28
Giardiasis. (8863037)
1996
29
A comparative clinical trial of albendazole versus metronidazole in giardiasis. (8613282)
1995
30
Secnidazole in the treatment of giardiasis. (8714630)
1995
31
Human giardiasis. A morphometric study of duodenal biopsy specimens in relation to the trophozoite count in the duodenal aspirate. (8080358)
1994
32
Evaluation of the immune response in symptomatic and asymptomatic human giardiasis. (7919807)
1994
33
The relation between ABO blood groups, HLA typing and giardiasis in children. (8077760)
1994
34
Prevalence of giardiasis among primary school children. (7955135)
1994
35
Efficacy of fenbendazole against giardiasis in dogs. (7978640)
1994
36
Peculiar histopathological features of giardiasis in distal duodenal biopsies. (7799507)
1994
37
Treating possible giardiasis. (8304864)
1993
38
Diarrhoea and malabsorption in giardiasis: a multifactorial process? (1568645)
1992
39
Factors associated with acquiring giardiasis in British Columbia residents. (1617559)
1992
40
Gastric giardiasis. (1452790)
1992
41
Lack of an association between endemic giardiasis and a drinking water source. (1473069)
1992
42
Giardiasis--a simple diagnosis that is often delayed. (1950049)
1991
43
Modification of RPMI 1640 for use in vitro immunological studies of host-parasite interactions in giardiasis. (2037682)
1991
44
Giardiasis and amoebiasis infections in three Saudi closed communities. (1995937)
1991
45
Pruritus without urticaria in acute giardiasis. (2382876)
1990
46
Severe giardiasis in two patients undergoing bone marrow transplantation. (2819289)
1989
47
Severe giardiasis in a child during cancer therapy. (2929575)
1989
48
Fever and urticaria in acute giardiasis. (2705846)
1989
49
Retinal arteritis, iridocyclitis, and giardiasis. (6891764)
1982
50
Giardiasis, isosporiasis and balantidiasis. (627102)
1978

Variations for Giardiasis

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Expression for genes affiliated with Giardiasis

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Search GEO for disease gene expression data for Giardiasis.

Pathways for genes affiliated with Giardiasis

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Compounds for genes affiliated with Giardiasis

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Compounds related to Giardiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
12-phosphoglycerate4510.2TPI1, ENO1
23-phosphoglycerate4510.2ENO1, TPI1
3pneumococcal4510.1CD79A, ENO1
4isocitrate4510.0TPI1, ENO1
5aldose459.9TPI1, ENO1
6concanamycin a45 6110.8GZMB, DNAH8
72,3-butanedione monoxime459.7DNAH8, MYLK
8ramipril45 1310.6CD79A, TGFB1
9pmma459.6CD79A, TGFB1
10fluoride459.6CD79A, DNAH8
11actomyosin459.6MYLK, DNAH8
12prednisolone45 30 1311.5DNAH8, GZMB, CD79A
13epinephrine45 26 1311.5CD79A, DNAH8, SCT
14phosphatidylserine45 30 1311.5DNAH8, GZMB, CD79A
15omeprazole45 51 30 26 1313.4DNAH8, SCT
16norepinephrine45 26 1311.4CD79A, DNAH8, SCT
17trifluoperazine45 30 51 1312.3DNAH8, MYLK
18acetylcholine45 51 30 26 1313.3SCT, DNAH8, CD79A
19glutaraldehyde459.2CD79A, DNAH8, TGFB1
20hyaluronic acid45 2610.2TGFB1, GZMB, CD79A
21tacrolimus45 51 1311.2CD79A, GZMB, TGFB1
22glycerol45 26 1311.2TPI1, DNAH8, LCT, CD79A
23theophylline45 30 26 1312.2CD79A, DNAH8, TGFB1
244-hydroxynonenal45 2610.2ENO1, DNAH8, TGFB1
25clonidine45 51 30 1312.1DNAH8, TGFB1, SCT
26rantes459.1SCT, TGFB1, GZMB
27hydrogen45 2610.1SCT, TPI1, DNAH8, LCT
28polysaccharide459.1TGFB1, DNAH8, CD79A
29histamine45 30 2611.0CD79A, TGFB1, SCT
30alginate459.0CD79A, TGFB1
31etoposide45 51 61 1312.0TGFB1, DNAH8, GZMB
32oxygen45 2610.0ENO1, GZMB, MYLK, TPI1
33thyroxine45 269.8CD79A, DNAH8, TGFB1, SCT
34indomethacin45 30 61 1311.8SCT, TGFB1, DNAH8, CD79A
35arginine458.8SCT, DNAH8, GZMB, ENO1, CD79A
36lipid458.8SCT, TPI1, LCT, GZMB, ENO1
37glutamine458.7SCT, TGFB1, DNAH8, ENO1
38lactate458.6TPI1, TGFB1, GZMB, ENO1, CD79A
39creatinine458.5TPI1, TGFB1, DNAH8, ENO1, CD79A
40estrogen458.4TGFB1, MYLK, GZMB, CD79A
41cyclosporin a45 30 6110.4SCT, TGFB1, DNAH8, GZMB, CD79A
42aspartate458.2SCT, TPI1, MYLK, DNAH8, GZMB, ENO1
43atp45 309.2SCT, TPI1, MYLK, DNAH8, GZMB, ENO1
44glucose458.2SCT, TPI1, MYLK, LCT, GZMB, ENO1
45alanine458.1TGFB1, MYLK, DNAH8, GZMB, CD79A
46retinoic acid45 269.0SCT, TGFB1, DNAH8, GZMB, ENO1, CD79A
47cysteine458.0SCT, TPI1, DNAH8, LCT, GZMB, ENO1
48calcium45 51 26 1310.9SCT, MYLK, DNAH8, LCT, GZMB, ENO1
49serine457.9SCT, TPI1, TGFB1, MYLK, GZMB, ENO1
50glutamate457.9CD79A, SCT, TPI1, MYLK, DNAH8, GZMB

GO Terms for genes affiliated with Giardiasis

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Biological processes related to Giardiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycolytic processGO:00060969.8ENO1, TPI1
2gluconeogenesisGO:00060949.5ENO1, TPI1
3carbohydrate metabolic processGO:00059759.2ENO1, LCT, TPI1

Products for genes affiliated with Giardiasis

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Sources for Giardiasis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet