Aliases & Classifications for Giardiasis

MalaCards integrated aliases for Giardiasis:

Name: Giardiasis 12 72 51 3 41 14 69
Infection by Giardia Lamblia 12
Beaver Feaver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10718
ICD10 32 A07.1
ICD9CM 34 007.1
MeSH 41 D005873
UMLS 69 C0017536

Summaries for Giardiasis

CDC : 3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards based summary : Giardiasis, also known as infection by giardia lamblia, is related to cryptosporidiosis and strongyloidiasis, and has symptoms including pruritus and fever. An important gene associated with Giardiasis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Apoptosis and Autophagy and Primary immunodeficiency. The drugs Azithromycin and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia : 72 Giardiasis, popularly known as beaver fever, is a parasitic disease caused by Giardia lamblia. About 10%... more...

Related Diseases for Giardiasis

Diseases related to Giardiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 cryptosporidiosis 30.5 CD40LG CD79A
2 strongyloidiasis 30.3 CD79A TGFB1
3 amebiasis 30.2 CD40LG CD79A
4 cryofibrinogenemia 29.6 CD40LG CD79A
5 immunoglobulin a deficiency 1 29.6 CD40LG CD79A
6 celiac disease 1 29.6 CD40LG CD79A GZMB
7 coccidiosis 29.5 CD40LG CD79A
8 gastrointestinal system disease 29.5 CD40LG CD79A SCT
9 granulomatous hepatitis 29.4 CD40LG CD79A
10 b cell deficiency 29.1 CD40LG CD79A
11 clonorchiasis 10.4 CD79A TGFB1
12 rapidly progressive glomerulonephritis 10.4 CD79A TGFB1
13 fibromuscular dysplasia 10.4 MYLK TGFB1
14 gingival disease 10.4 CD79A TGFB1
15 erythema multiforme 10.4 CD79A GZMB
16 orbit lymphoma 10.4 GZMB TIA1
17 lichen sclerosus et atrophicus 10.4 GZMB TIA1
18 lymphomatoid granulomatosis 10.4 GZMB TIA1
19 subcutaneous panniculitis-like t-cell lymphoma 10.3 GZMB TIA1
20 lymphocytic gastritis 10.3 GZMB TIA1
21 primary cutaneous anaplastic large cell lymphoma 10.3 GZMB TIA1
22 natural killer cell leukemia 10.3 GZMB TIA1
23 composite lymphoma 10.3 GZMB TIA1
24 hepatosplenic t-cell lymphoma 10.3 GZMB TIA1
25 paranasal sinus disease 10.3 CD79A TGFB1
26 choriocarcinoma of the testis 10.3 GZMB TIA1
27 lymphomatoid papulosis 10.3 GZMB TIA1
28 ocular cicatricial pemphigoid 10.3 CD79A TGFB1
29 peripheral t-cell lymphoma 10.3 GZMB TIA1
30 infiltrating lipoma 10.3 GZMB TIA1
31 necrotizing sialometaplasia 10.3 GZMB TIA1
32 sialolithiasis 10.3 GZMB TGFB1
33 panniculitis 10.2 GZMB TIA1
34 duodenitis 10.2
35 selective igg deficiency disease 10.2 CD40LG CD79A
36 c1q nephropathy 10.2 CD40LG CD79A
37 meningovascular neurosyphilis 10.2 CD40LG CD79A
38 alpha chain disease 10.2 CD40LG CD79A
39 brill-zinsser disease 10.2 CD40LG CD79A
40 exudative glomerulonephritis 10.2 CD40LG CD79A
41 cork-handlers' disease 10.2 CD40LG CD79A
42 salpingo-oophoritis 10.2 CD40LG CD79A
43 early yaws 10.2 CD40LG CD79A
44 ventilation pneumonitis 10.2 CD40LG CD79A
45 chronic interstitial cystitis 10.1 CD40LG CD79A
46 axillary adenitis 10.1 CD40LG CD79A
47 trichostrongyloidiasis 10.1 CD40LG CD79A
48 subacute bacterial endocarditis 10.1 CD40LG CD79A
49 heterophyiasis 10.1 CD40LG CD79A
50 immunoglobulin g deficiency 10.1 CD40LG CD79A

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to Giardiasis

Symptoms & Phenotypes for Giardiasis

UMLS symptoms related to Giardiasis:


pruritus, fever

Drugs & Therapeutics for Giardiasis

Drugs for Giardiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
2
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
3
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
4 Anti-Bacterial Agents Phase 4,Phase 2
5 Antibiotics, Antitubercular Phase 4,Phase 2
6 Anti-Infective Agents Phase 4,Phase 2,Phase 3
7 Antiparasitic Agents Phase 4,Phase 2,Phase 3
8 Antiprotozoal Agents Phase 4,Phase 2
9 Alkylating Agents Phase 4
10
Lactulose Approved Phase 2, Phase 3 4618-18-2 11333
11
Nitazoxanide Approved, Investigational, Vet_approved Phase 2, Phase 3 55981-09-4 41684
12 Gastrointestinal Agents Phase 2, Phase 3
13
Auranofin Approved, Investigational Phase 2 34031-32-8 6918453 6333901
14
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
15 Antirheumatic Agents Phase 2
16 Liver Extracts Phase 2
17
Albendazole Approved, Vet_approved 54965-21-8 2082
18
Secnidazole Approved 3366-95-8
19
Iron Approved 7439-89-6 23925
20
Methadone Approved 76-99-3 4095
21
Formaldehyde Approved, Vet_approved 50-00-0 712
22 Antibodies
23 Immunoglobulins
24 Anthelmintics
25 Antimitotic Agents
26 Disinfectants
27 Ether
28 Vaccines

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Giardia Induced Fatigue and Functional Gastrointestinal Diseases Completed NCT00860236 Phase 4
2 Mortality Reduction After Oral Azithromycin: Morbidity Study Completed NCT02048007 Phase 4 Azithromycin;Placebo
3 Treatment of Giardia Lamblia Infections in Children Recruiting NCT02942485 Phase 4 Metronidazole;Tinidazole
4 Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy Recruiting NCT02464124 Phase 2, Phase 3 Nitazoxanide;Lactulose
5 Auranofin Trial for GI Protozoa Recruiting NCT02736968 Phase 2 Auranofin
6 Optimising Antibiotic Treatment for Sick Malnourished Children Active, not recruiting NCT02746276 Phase 2 Ceftriaxone;Metronidazole
7 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
8 Impact of Anti-Giardia and Antihelmintic Treatment on Infant Growth in Bangladesh Completed NCT00607074 Anti-Giardia and antihelmintic treatment (secnidazole or albendazole);Anti-Giardia treatment only (secnidazole or albendazole);Control group (placebo)
9 Malabsorption as a Cause of Iron Treatment Failure in Infants Completed NCT00456729 Metronidazole
10 Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison Completed NCT00739258
11 Fecal Transplantation in Patients With IBS Completed NCT03333291
12 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
13 Normative State and Variation in Growth, Hematology, Hydration, Oxidation, Infection, Inflammation, Guatemalan Children Completed NCT02203890
14 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
15 SaniVac Trial - Sanitation and Oral Rotavirus Vaccine Performance Recruiting NCT03313128
16 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Giardiasis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: giardiasis

Genetic Tests for Giardiasis

Anatomical Context for Giardiasis

MalaCards organs/tissues related to Giardiasis:

38
Small Intestine, Testes, Liver, Pancreas, Skin, Colon, Bone

Publications for Giardiasis

Articles related to Giardiasis:

(show top 50) (show all 594)
# Title Authors Year
1
Under-reporting giardiasis; Time to consider the public health implications - ERRATUM. ( 29352816 )
2018
2
Under-reporting giardiasis: time to consider the public health implications. ( 28879824 )
2017
3
The influence of serial fecal sampling on the diagnosis of giardiasis in humans, dogs, and cats. ( 28902297 )
2017
4
Prophylactic Potential of Synbiotic (Lactobacillus casei and Inulin) in Malnourished Murine Giardiasis: an Immunological and Ultrastructural Study. ( 29260483 )
2017
5
The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis. ( 28830665 )
2017
6
Associations between extreme precipitation and acute gastro-intestinal illness due to cryptosporidiosis and giardiasis in an urban Canadian drinking water system (1997-2009). ( 29215354 )
2017
7
Giardiasis Treatment Challenges in a Pediatric International Adoption Clinic. ( 28056536 )
2017
8
Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis. ( 28842650 )
2017
9
Nitroimidazole-refractory giardiasis: a growing problem requiring rational solutions. ( 28624613 )
2017
10
Giardiasis Outbreak Associated with Asymptomatic Food Handlers in New York State, 2015. ( 28402185 )
2017
11
Diffuse Nodular Lymphoid Hyperplasia of the Intestine Caused by Common Variable Immunodeficiency and Refractory Giardiasis. ( 28154271 )
2017
12
Giardiasis Diagnosis and Treatment Practices Among Commercially Insured Persons in the United States. ( 28207070 )
2017
13
Foodborne giardiasis: Is there any relationship between food handlers and transmission of Giardia duodenalis? ( 28079004 )
2017
14
Spontaneous Resolution of Pancreatic Cyst After Treatment for Giardiasis. ( 28085756 )
2017
15
Giardiasis mimicking celiac disease in a patient of common variable immunodeficiency. ( 29114494 )
2017
16
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome. ( 28129747 )
2017
17
Antigiardial Effect of Kramecyne in Experimental Giardiasis. ( 29387130 )
2017
18
Incidental giardiasis diagnosed during transduodenal EUS-FNA. ( 28713065 )
2017
19
Giardiasis as a neglected disease in Brazil: Systematic review of 20 years of publications. ( 29065126 )
2017
20
Significance of Nitric Oxide Level in Giardiasis. ( 28164484 )
2017
21
Could the Fight Against Treatment Failures in Giardiasis Lead to a Second Childhood for Quinacrine? ( 28973255 )
2017
22
Comparative efficacy of drugs for treating giardiasis: a systematic update of the literature and network meta-analysis of randomized clinical trials. ( 29186570 )
2017
23
TLR2<sup>-/-</sup>Mice Display Decreased Severity of Giardiasis<i>via</i>Enhanced Proinflammatory Cytokines Production Dependent on AKT Signal Pathway. ( 28979269 )
2017
24
Stimulated and Unstimulated Saliva Levels of Calcium and Magnesium in Giardiasis. ( 28111708 )
2017
25
Giardiasis and Subsequent Irritable Bowel Syndrome: A Longitudinal Cohort Study Using Health Insurance Data. ( 28329069 )
2017
26
A novel inA vitro image-based assay identifies new drug leads for giardiasis. ( 28171818 )
2017
27
Estimating and mapping the incidence of giardiasis in Colombia, 2009-2013. ( 27312583 )
2016
28
Giardiasis and Nodular Lymphoid Hyperplasia of the Duodenum. ( 27125704 )
2016
29
Giardiasis: an update review on sensitivity and specificity of methods for laboratorial diagnosis. ( 27546714 )
2016
30
Postinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasis. ( 27189227 )
2016
31
Giardiasis in NSW: Identification of Giardia duodenalis assemblages contributing to human and cattle cases, and an epidemiological assessment of sporadic human giardiasis. ( 27370572 )
2016
32
Giardiasis in the United States - an epidemiologic and geospatial analysis of county-level drinking water and sanitation data, 1993-2010. ( 27105412 )
2016
33
Evolution of Socioeconomic Conditions and Its Relation to Spatial-Temporal Changes of Giardiasis and Helminthiasis in Amazonian Children. ( 27638472 )
2016
34
Demonstration of Trophozoites of G. Lamblia in Ileal Mucosal Biopsy Specimens May Reveal Giardiasis in Patients With Significantly Inflamed Parasite-free Duodenal Mucosa. ( 27186850 )
2016
35
An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. ( 27864517 )
2016
36
Chronic Giardiasis in a Case of Common Variable Immunodeficiency (CVID): A Case Report. ( 27630845 )
2016
37
Control of Giardiasis by Interleukin-17 in Humans and Mice--Are the Questions All Answered? ( 26581888 )
2016
38
Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far. ( 27349189 )
2016
39
Adaptive immune response in symptomatic and asymptomatic enteric protozoal infection: evidence for a determining role of parasite genetic heterogeneity in host immunity to human giardiasis. ( 27401766 )
2016
40
Giardiasis outbreaks in the United States, 1971-2011. ( 26750152 )
2016
41
A Prospective Longitudinal Cohort to Investigate the Effects of Early Life Giardiasis on Growth and All Cause Diarrhea. ( 27313261 )
2016
42
Incidence rate and risk factors for giardiasis and strongyloidiasis in returning UK travellers. ( 27432907 )
2016
43
Giardiasis. ( 27789441 )
2016
44
IMMUNOTHERAPEUTIC EFFECT OF SPIRAMYCIN IN EXPERIMENTAL GIARDIASIS. ( 27363037 )
2016
45
Molecular detection of giardiasis among children at Cairo University Pediatrics Hospitals. ( 27876969 )
2016
46
Introducing nitazoxanide as a promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in clinical isolates. ( 27633304 )
2016
47
Sequelae of giardiasis: an emerging public health concern. ( 27312579 )
2016
48
An up-date on Giardia and giardiasis. ( 27501461 )
2016
49
Contribution of environmental media to cryptosporidiosis and giardiasis prevalence in Tehran: a focus on surface waters. ( 27370533 )
2016
50
Perceived food intolerance and irritable bowel syndrome in a population 3A years after a giardiasis-outbreak: a historical cohort study. ( 26585714 )
2015

Variations for Giardiasis

Expression for Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for Giardiasis

Pathways related to Giardiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.07 CD40LG GZMB TIA1
2 10.72 CD40LG CD79A
3
Show member pathways
10.51 GZMB TGFB1

GO Terms for Giardiasis

Biological processes related to Giardiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycolytic process GO:0006096 9.16 ENO1 TPI1
2 B cell proliferation GO:0042100 8.96 CD40LG CD79A
3 canonical glycolysis GO:0061621 8.62 ENO1 TPI1

Sources for Giardiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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