MCID: GRD001
MIFTS: 55

Giardiasis malady

Infectious diseases category
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Summaries for Giardiasis

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Sources:
8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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CDC:4 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards: Giardiasis, also known as infection by giardia lamblia, is related to diarrhea and celiac disease. An important gene associated with Giardiasis is TPI1 (triosephosphate isomerase 1), and among its related pathways are Glucose metabolism and MPS VI - Maroteaux-Lamy syndrome. The drugs albendazole and metronidazole and the compounds 2-phosphoglycerate and 3-phosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite giardia intestinalis. the symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia:65 Giardiasis (popularly known as beaver fever) is a zoonotic parasitic disease caused by the flagellate... more...

Aliases & Classifications for Giardiasis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

giardiasis 8 10 45 62
infection by giardia lamblia 8
beaver feaver 8


External Ids:

Disease Ontology8 DOID:10718
ICD9CM27 007.1
MeSH35 D005873
ICD1025 A07.1

Related Diseases for Giardiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Giardiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.4LCT, CD79A
2celiac disease30.2CD79A, LCT, GZMB
3pancreatic cancer30.1ENO1, TGFB1, SCT
4lactose intolerance30.0LCT
5hepatitis29.9GZMB, TGFB1
6inflammatory bowel disease29.9CD79A, TGFB1
7cystic fibrosis29.9DNAH8, SCT
8leukemia29.7TGFB1, CD79A, DNAH8, GZMB, ENO1
9cryptosporidiosis10.5
10duodenitis10.5
11amebiasis10.3
12ascariasis10.2
13helminthiasis10.2
14deficiency anemia10.1
15trichomoniasis10.1
16iron deficiency anemia10.1
17protein-losing enteropathy10.1
18pancreatitis10.1
19exanthem10.1CD79A
20epidermolysis bullosa acquisita10.1CD79A
21exocrine pancreatic insufficiency10.1SCT
22zollinger-ellison syndrome10.1SCT
23infectious mononucleosis10.1TPI1, CD79A
24measles10.1CD79A, SCT
25chronic fatigue syndrome10.1
26irritable bowel syndrome10.1
27common variable immunodeficiency10.1
28agammaglobulinemia10.1
29intestinal disease10.1
30urticaria10.1
31glucose intolerance10.1CD79A, LCT
32lupus nephritis10.0CD79A, TGFB1
33glomerulosclerosis10.0TGFB1, CD79A
34connective tissue disease10.0CD79A, TGFB1
35iga glomerulonephritis10.0CD79A, TGFB1
36skin disease10.0TGFB1, GZMB
37sjogren's syndrome10.0CD79A, GZMB
38systemic lupus erythematosus10.0TPI1, CD79A, ENO1
39ulcerative colitis10.0GZMB, ENO1, CD79A
40vasculitis10.0ENO1, CD79A
41intrahepatic cholestasis10.0SCT, DNAH8
42gastroesophageal reflux disease10.0SCT, DNAH8
43peptic ulcer disease10.0SCT, DNAH8
44pancreatitis, chronic10.0SCT, TGFB1
45tuberculosis10.0ENO1, TPI1, CD79A, GZMB
46dermatitis10.0CD79A, GZMB
47primary biliary cirrhosis10.0SCT, GZMB, ENO1, CD79A
48gastritis10.0SCT, CD79A, DNAH8
49herpes simplex10.0ENO1, CD79A, DNAH8
50influenza10.0GZMB, DNAH8, CD79A

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to giardiasis

Symptoms for Giardiasis

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Drugs & Therapeutics for Giardiasis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Giardiasis

Search NIH Clinical Center for Giardiasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Giardiasis

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Anatomical Context for Giardiasis

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33MalaCards
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MalaCards organs/tissues related to Giardiasis:

33
Small intestine, Testes, Pancreas, Skin, Colon, Smooth muscle, T cells, B cells, Liver, Breast

Animal Models for Giardiasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Giardiasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.9CD79A, GZMB, MYLK, TGFB1, TPI1
2MP:00053767.2CD79A, SCT, TPI1, TGFB1, MYLK, GZMB

Publications for Giardiasis

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52PubMed
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Articles related to Giardiasis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Giardiasis in a patient undergoing chemotherapy for retinoblastoma and acute myelogenous leukemia. (23910805)
2013
2
Secnidazole for the treatment of giardiasis in naturally infected cats. (21763779)
2011
3
Mebendazole compared with secnidazole in the treatment of adult giardiasis: a randomised, no-inferiority, open clinical trial. (22174992)
2011
4
Caregiver perspectives for the prevention, diagnosis and treatment of childhood giardiasis in Havana City, Cuba. A qualitative study. (21565150)
2011
5
Risk factors for endemic giardiasis: highlighting the possible association of contaminated water and food. (18377940)
2008
6
Survey of feline giardiasis by ELISA test in Italy. (17195926)
2007
7
Investigation of potential zooanthroponotic transmission of cryptosporidiosis and giardiasis through agricultural use of reclaimed wastewater. (17164167)
2006
8
Risk of giardiasis associated with water supply in an endemic context. (16990176)
2006
9
Giardiasis surveillance--United States, 1998-2002. (15674189)
2005
10
Determinants of the geographical distribution of endemic giardiasis in Ontario, Canada: a spatial modelling approach. (15473161)
2004
11
Albendazole as an alternative therapeutic agent for childhood giardiasis in Turkey. (15191380)
2004
12
Prevalence of Giardiasis due to wastewater reuse for agriculture in the suburbs of Asmara City, Eritrea. (14660117)
2004
13
Antitransglutaminase antibodies and giardiasis. (15571608)
2004
14
Symptomatic giardiasis without diarrhea: further evidence to support the routine duodenal biopsy? (12838238)
2003
15
Geographical and temporal distribution of human giardiasis in Ontario, Canada. (12946275)
2003
16
Whipple disease associated with giardiasis. (12964113)
2003
17
Giardiasis treatment in Turkish children with a single dose of ornidazole. (12587625)
2002
18
Risk of giardiasis in Aucklanders: a case-control study. (12718834)
2002
19
Neuroblastoma with concomitant giardiasis: report of a case with diagnosis by fine needle aspiration cytology. (11575653)
2001
20
Giardiasis-associated arthralgia in children. (11471528)
2001
21
Serum vitamin A and beta-carotene levels in children with giardiasis before and after treatment. (9718915)
1998
22
Efficacy of a drug combination of praziquantel, pyrantel pamoate, and febantel against giardiasis in dogs. (9736391)
1998
23
A study on the relation between proton pump inhibitor and gastric giardiasis. (9617051)
1998
24
Efficacy of fenbendazole for treatment of giardiasis in calves. (9099384)
1997
25
Case in point. Small bowel giardiasis. (9307595)
1997
26
Symptoms in patients with giardiasis undergoing upper gastrointestinal endoscopy. (9427489)
1997
27
Intestinal lymphangiectasia due to recurrent giardiasis. (8607534)
1996
28
Single-dose secnidazole versus 10-day metronidazole therapy of giardiasis in Iranian children. (8699592)
1996
29
Giardiasis. (8863037)
1996
30
A comparative clinical trial of albendazole versus metronidazole in giardiasis. (8613282)
1995
31
Secnidazole in the treatment of giardiasis. (8714630)
1995
32
Human giardiasis. A morphometric study of duodenal biopsy specimens in relation to the trophozoite count in the duodenal aspirate. (8080358)
1994
33
Evaluation of the immune response in symptomatic and asymptomatic human giardiasis. (7919807)
1994
34
The relation between ABO blood groups, HLA typing and giardiasis in children. (8077760)
1994
35
Prevalence of giardiasis among primary school children. (7955135)
1994
36
Efficacy of fenbendazole against giardiasis in dogs. (7978640)
1994
37
Peculiar histopathological features of giardiasis in distal duodenal biopsies. (7799507)
1994
38
Treating possible giardiasis. (8304864)
1993
39
Diarrhoea and malabsorption in giardiasis: a multifactorial process? (1568645)
1992
40
Factors associated with acquiring giardiasis in British Columbia residents. (1617559)
1992
41
Gastric giardiasis. (1452790)
1992
42
Lack of an association between endemic giardiasis and a drinking water source. (1473069)
1992
43
Giardiasis--a simple diagnosis that is often delayed. (1950049)
1991
44
Modification of RPMI 1640 for use in vitro immunological studies of host-parasite interactions in giardiasis. (2037682)
1991
45
Giardiasis and amoebiasis infections in three Saudi closed communities. (1995937)
1991
46
Pruritus without urticaria in acute giardiasis. (2382876)
1990
47
Severe giardiasis in a child during cancer therapy. (2929575)
1989
48
Fever and urticaria in acute giardiasis. (2705846)
1989
49
Retinal arteritis, iridocyclitis, and giardiasis. (6891764)
1982
50
Giardiasis, isosporiasis and balantidiasis. (627102)
1978

Variations for Giardiasis

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Expression for genes affiliated with Giardiasis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for genes affiliated with Giardiasis

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems
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Compounds for genes affiliated with Giardiasis

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Sources:
45Novoseek, 61Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 51PharmGKB
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Compounds related to Giardiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
12-phosphoglycerate4510.2TPI1, ENO1
23-phosphoglycerate4510.2ENO1, TPI1
3pneumococcal4510.1CD79A, ENO1
4isocitrate4510.0TPI1, ENO1
5aldose459.9TPI1, ENO1
6concanamycin a45 6110.8GZMB, DNAH8
72,3-butanedione monoxime459.7DNAH8, MYLK
8ramipril45 1110.6CD79A, TGFB1
9pmma459.6TGFB1, CD79A
10fluoride459.6DNAH8, CD79A
11actomyosin459.6DNAH8, MYLK
12prednisolone45 29 1111.5CD79A, GZMB, DNAH8
13epinephrine45 24 1111.5DNAH8, SCT, CD79A
14phosphatidylserine45 29 1111.5GZMB, DNAH8, CD79A
15omeprazole45 51 29 24 1113.4DNAH8, SCT
16norepinephrine45 24 1111.4SCT, DNAH8, CD79A
17trifluoperazine45 29 51 1112.3DNAH8, MYLK
18acetylcholine45 51 29 24 1113.3SCT, DNAH8, CD79A
19glutaraldehyde459.2TGFB1, CD79A, DNAH8
20hyaluronic acid45 2410.2CD79A, GZMB, TGFB1
21tacrolimus45 51 1111.2CD79A, GZMB, TGFB1
22glycerol45 24 1111.2LCT, DNAH8, TPI1, CD79A
23theophylline45 29 24 1112.2DNAH8, CD79A, TGFB1
244-hydroxynonenal45 2410.2ENO1, TGFB1, DNAH8
25clonidine45 51 29 1112.1TGFB1, SCT, DNAH8
26rantes459.1GZMB, TGFB1, SCT
27hydrogen45 2410.1SCT, TPI1, DNAH8, LCT
28polysaccharide459.1TGFB1, CD79A, DNAH8
29histamine45 29 2411.0CD79A, SCT, TGFB1
30alginate459.0CD79A, TGFB1
31etoposide45 51 61 1112.0TGFB1, GZMB, DNAH8
32oxygen45 2410.0MYLK, ENO1, GZMB, TPI1
33thyroxine45 249.8CD79A, DNAH8, TGFB1, SCT
34indomethacin45 29 61 1111.8TGFB1, DNAH8, CD79A, SCT
35arginine458.8DNAH8, GZMB, ENO1, SCT, CD79A
36lipid458.8SCT, TPI1, LCT, GZMB, ENO1
37glutamine458.7SCT, ENO1, DNAH8, TGFB1
38lactate458.6GZMB, TGFB1, ENO1, CD79A, TPI1
39creatinine458.5DNAH8, TPI1, ENO1, TGFB1, CD79A
40estrogen458.4GZMB, MYLK, CD79A, TGFB1
41cyclosporin a45 29 6110.4GZMB, DNAH8, TGFB1, SCT, CD79A
42aspartate458.2GZMB, SCT, TPI1, MYLK, DNAH8, ENO1
43atp45 299.2GZMB, DNAH8, MYLK, SCT, TPI1, ENO1
44glucose458.2LCT, MYLK, SCT, TPI1, GZMB, ENO1
45alanine458.1TGFB1, GZMB, DNAH8, MYLK, CD79A
46retinoic acid45 249.0DNAH8, CD79A, ENO1, TGFB1, GZMB, SCT
47cysteine458.0SCT, TPI1, DNAH8, GZMB, LCT, ENO1
48calcium45 51 24 1110.9SCT, ENO1, MYLK, DNAH8, LCT, GZMB
49serine457.9TPI1, GZMB, MYLK, TGFB1, SCT, ENO1
50glutamate457.9DNAH8, MYLK, TPI1, SCT, ENO1, CD79A

GO Terms for genes affiliated with Giardiasis

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16Gene Ontology
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Biological processes related to Giardiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycolytic processGO:0060969.8ENO1, TPI1
2gluconeogenesisGO:0060949.5ENO1, TPI1
3carbohydrate metabolic processGO:0059759.2ENO1, LCT, TPI1

Products for genes affiliated with Giardiasis

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Sources for Giardiasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet