MCID: GRD001
MIFTS: 54

Giardiasis malady

Infectious diseases category

Summaries for Giardiasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards: Giardiasis, also known as infection by giardia lamblia, is related to diarrhea and deficiency anemia. An important gene associated with Giardiasis is TPI1 (triosephosphate isomerase 1), and among its related pathways are Fructose catabolism and Glucose metabolism. The drugs albendazole and metronidazole and the compounds 2-phosphoglycerate and 3-phosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite giardia intestinalis. the symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia:63 Giardiasis (popularly known as beaver fever) is a parasitic disease caused by the flagellate protozoan... more...

Aliases & Classifications for Giardiasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

giardiasis 8 10 44 60
infection by giardia lamblia 8
beaver feaver 8


External Ids:

Disease Ontology8 DOID:10718
ICD9CM27 007.1
MeSH34 D005873
ICD1025 A07.1

Related Diseases for Giardiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Giardiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.3CD79A, LCT, SI
2deficiency anemia30.1CD79A, TPI1
3pancreatitis30.1TGFB1, SCT
4celiac disease30.1GZMB, LCT, CD79A
5lactose intolerance30.0LCT
6irritable bowel syndrome30.0LCT
7urticaria30.0GZMB
8hypothyroidism30.0DNAH8
9pancreatic cancer30.0TGFB1, SCT, ENO1
10thyroiditis29.8CD79A
11inflammatory bowel disease29.8CD79A, TGFB1
12hepatitis29.8GZMB, OTC, TPI1
13myopathy29.8TPI1, DNAH8
14cystic fibrosis29.7OTC, SI, DNAH8, TREH, SCT
15leukemia29.7GZMB, BAG3, DNAH8, OTC, TGFB1, ENO1
16cryptosporidiosis10.5
17duodenitis10.4
18amebiasis10.3
19ascariasis10.2
20trichomoniasis10.1
21iron deficiency anemia10.1
22protein-losing enteropathy10.1
23chronic fatigue syndrome10.1
24intestinal disease10.1
25common variable immunodeficiency10.0
26agammaglobulinemia10.0
27thrombocytopenia10.0CD79A
28duodenal ulcer10.0SCT
29prostatitis10.0CD79A
30interstitial lung disease10.0CD79A
31sarcoidosis10.0GZMB
32alopecia areata10.0GZMB
33schistosomiasis10.0CD79A
34zollinger-ellison syndrome10.0SCT
35epidermolysis bullosa acquisita10.0CD79A
36exanthem10.0CD79A
37lung cancer10.0TGFB1
38infectious mononucleosis10.0CD79A, TPI1
39exocrine pancreatic insufficiency10.0SCT
40pulmonary disease, chronic obstructive10.0TGFB1
41pneumonia10.0CD79A, TGFB1
42glomerulonephritis10.0TGFB1, CD79A
43eye disease10.0TGFB1
44skin disease10.0TGFB1, GZMB
45gingivitis10.0SI
46tuberculosis10.0TPI1, ENO1, CD79A, GZMB
47primary biliary cirrhosis10.0ENO1, CD79A, GZMB, SCT
48glucose intolerance10.0CD79A, LCT, SI
49peptic ulcer10.0DNAH8, SCT
50hepatitis c10.0ENO1, DNAH8

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to giardiasis

Clinical Features for Giardiasis

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Drugs & Therapeutics for Giardiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Giardiasis

Drug clinical trials:

Search ClinicalTrials for Giardiasis

Search NIH Clinical Center for Giardiasis

Search CenterWatch for Giardiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Giardiasis

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Anatomical Context for Giardiasis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Giardiasis:

32
Small intestine, Testes, Pancreas, Colon, Skin, T cells, Breast, Thyroid, Bone marrow, Liver, Smooth muscle, Bone, B cells

Animal Models for Giardiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Giardiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3TGFB1, TPI1, OTC, CD79A, MYLK, TREH

Publications for Giardiasis

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50PubMed
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Articles related to Giardiasis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Changes in serum zinc levels associated with giardiasis and dietary zinc intake in mice. (21952867)
2012
2
Mebendazole compared with secnidazole in the treatment of adult giardiasis: a randomised, no-inferiority, open clinical trial. (22174992)
2011
3
Severe eosinophilia in a case of giardiasis. (21625313)
2011
4
Human cellular immune response against Giardia lamblia 5 years after acute giardiasis. (21990423)
2011
5
Giardiasis: the ever-present threat of a neglected disease. (20701575)
2010
6
Influence of Enterococcus faecium SF68 probiotic on giardiasis in dogs. (19298607)
2009
7
Treatment of giardiasis in common marmosets (Callithrix jacchus) with tinidazole. (19389310)
2009
8
Surveillance of giardiasis in Northwest England 1996-2006: impact of an enzyme immunoassay test. (18801316)
2008
9
WITHDRAWN: Drugs for treating giardiasis. (17636622)
2007
10
Effect of propolis versus metronidazole and their combined use in treatment of acute experimental giardiasis. (17926808)
2007
11
Giardiasis and cryptosporidiosis in ruminants. (17071357)
2006
12
Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children. (17072963)
2006
13
Giardiasis as a predictor of childhood malnutrition in Orang Asli children in Malaysia. (15992838)
2005
14
Cutaneous manifestation of giardiasis - case report. (16457489)
2005
15
Common variable immunodeficiency (CVID) presenting with malabsorption due to giardiasis. (16252205)
2005
16
Nitazoxanide treatment for giardiasis and cryptosporidiosis in children. (14990779)
2004
17
Human giardiasis as an etiology of skin allergy: the role of adhesion molecules and interleukin-6. (15587302)
2004
18
Geographical and temporal distribution of human giardiasis in Ontario, Canada. (12946275)
2003
19
Comparison of chloroquine, albendazole and tinidazole in the treatment of children with giardiasis. (12831522)
2003
20
Single-dose therapy for giardiasis in school-age children. (12757214)
2002
21
Nappy handling and risk of giardiasis. (11293600)
2001
22
Treatment of giardiasis reverses "active" coeliac disease to "latent" coeliac disease. (11564963)
2001
23
Diagnosis of giardiasis using an enzyme-linked immunosorbent assay (ELISA) on formalin preserved stools. (17216923)
2000
24
Giardiasis surveillance--United States, 1992-1997. (10955980)
2000
25
Giardiasis in ringed seals from the western arctic. (9249716)
1997
26
Mast cell hyperplasia and increased macromolecular uptake in an animal model of giardiasis. (9379297)
1997
27
Secondary impairment of pancreatic function as a cause of severe malabsorption in intestinal giardiasis: a case report. (9230786)
1997
28
A systematic review on the treatment of giardiasis. (9018304)
1997
29
Giardiasis as a cause of hypokalemic myopathy in congenital immunodeficiency. (8856367)
1996
30
Giardiasis and amebiasis in southern Iran. (8979598)
1996
31
Determinants of symptomatic giardiasis in childhood. (8783980)
1996
32
Evaluation of the immune response in symptomatic and asymptomatic human giardiasis. (7919807)
1994
33
Giardiasis. (8036778)
1994
34
Diarrhoea and malabsorption in giardiasis: a multifactorial process? (1568645)
1992
35
Factors associated with acquiring giardiasis in British Columbia residents. (1617559)
1992
36
Restaurant-associated outbreak of giardiasis. (1500757)
1992
37
Giardiasis mimicking inflammatory bowel disease. (1538290)
1992
38
Giardiasis causing chronic diarrhoea in suburban Copenhagen: incidence, physical growth, clinical symptoms and small intestinal abnormality. (1467610)
1992
39
Single-dose ornidazole versus seven-day metronidazole therapy of giardiasis in Kibbutzim children in Israel. (1794369)
1991
40
Prevalence and treatment of giardiasis in chronic diarrhoea and malnutrition. (2025005)
1991
41
Pruritus without urticaria in acute giardiasis. (2382876)
1990
42
Intestinal giardiasis associated with ophthalmologic changes. (2395058)
1990
43
Propranolol and metronidazole for the treatment of metronidazole-resistant giardiasis. (2230010)
1990
44
Fever and urticaria in acute giardiasis. (2705846)
1989
45
Efficacy of tinidazole (Fasigyn) in giardiasis by parasitologic, biochemical, and gut transit studies. (2707840)
1989
46
Back-country water treatment to prevent giardiasis. (2817191)
1989
47
Giardiasis in Iowa. (2722462)
1989
48
Zoonotic aspects of giardiasis: a review. (2672545)
1989
49
Misdiagnosis of sarcocystosis as giardiasis. (3094171)
1986
50
Giardiasis with malabsorption in X-linked agammaglobulinemia. (5041703)
1972

Genetic Variations for Giardiasis

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Expression for genes affiliated with Giardiasis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for genes affiliated with Giardiasis

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Giardiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3SI, ALDOC
2
Hide members
9.2TPI1, ALDOC, ENO1
39.1SI, TREH, LCT
4
Hide members
8.8OTC, ENO1, ALDOC, TPI1
5
Hide members
8.5TPI1, ALDOC, ENO1, OTC, SI
6
Hide members
7.8TPI1, LCT, TREH, SI, ENO1, ALDOC

Compounds for genes affiliated with Giardiasis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 11DrugBank
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Compounds related to Giardiasis according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
12-phosphoglycerate4410.4TPI1, ENO1
23-phosphoglycerate4410.3TPI1, ENO1
3pneumococcal4410.2ENO1, CD79A
4lactulose4410.1CD79A, SI
5butyrate4410.1OTC, SI
6phlorizin44 28 5912.0SI, LCT
7oxygen44 2411.0SI
8gliadin4410.0SI, CD79A
9ramipril44 1110.9TGFB1, CD79A
102,3-butanedione monoxime449.9DNAH8, MYLK
11phosphoenolpyruvate44 1110.9SI, OTC, ENO1
12malate449.8TPI1, OTC, DNAH8
13scopolamine44 28 11 2412.7SI, DNAH8
14pmma449.7TGFB1, CD79A
15carnitine449.7OTC, CD79A, DNAH8
16pyruvate449.7SI, OTC, ENO1, TPI1
17prednisolone44 28 1111.6GZMB, DNAH8, CD79A
18glutaraldehyde449.6TGFB1, CD79A, DNAH8
19estrogen449.6SI, CD79A
20clonidine44 28 1111.5SCT, DNAH8, TGFB1
21theophylline44 28 11 2412.5TGFB1, CD79A, DNAH8
224-hydroxynonenal44 2410.5DNAH8, ENO1, TGFB1
23hyaluronic acid44 2410.5GZMB, CD79A, TGFB1
24fatty acid449.5SI, OTC, ENO1, TPI1
25thyroxine44 2410.3SCT, DNAH8, CD79A, TGFB1
26paraffin449.3GZMB, CD79A, SI, TGFB1
27indomethacin44 59 28 1112.3SCT, DNAH8, CD79A, TGFB1
28carbon449.3TPI1, SI, TREH
29glycerol44 11 2411.2LCT, DNAH8, CD79A, OTC, TPI1
30polysaccharide449.1DNAH8, CD79A, SI, TGFB1
31cyclosporin a44 28 5911.0GZMB, SCT, DNAH8, CD79A, TGFB1
32creatinine448.8DNAH8, CD79A, OTC, ENO1, TPI1, TGFB1
33aspartate448.8TPI1, SCT, MYLK, DNAH8, SI, OTC
34lipid448.8LCT, GZMB, SCT, SI, OTC, ENO1
35retinoic acid44 249.7GZMB, SCT, DNAH8, CD79A, ENO1, TGFB1
36lactate448.7GZMB, CD79A, SI, OTC, ENO1, TPI1
37glutamine448.6SCT, DNAH8, SI, OTC, ENO1, TGFB1
38arginine448.6GZMB, SCT, DNAH8, CD79A, SI, OTC
39atp44 289.6GZMB, SCT, MYLK, DNAH8, OTC, ENO1
40hydrogen44 249.5LCT, SCT, TREH, DNAH8, SI, TPI1
41cysteine448.4LCT, GZMB, SCT, DNAH8, CD79A, SI
42glutamate448.4GZMB, SCT, MYLK, DNAH8, CD79A, OTC
43alanine447.9GZMB, TREH, MYLK, DNAH8, CD79A, SI
44glucose447.8LCT, GZMB, SCT, TREH, MYLK, SI

GO Terms for genes affiliated with Giardiasis

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16Gene Ontology
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Biological processes related to Giardiasis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1polysaccharide digestionGO:0442459.3SI, TREH, LCT
2gluconeogenesisGO:0060949.2TPI1, ALDOC, ENO1
3glycolysisGO:0060969.2ENO1, ALDOC, TPI1
4positive regulation of cell migrationGO:0303359.1TGFB1, MYLK, SYNE2
5glucose metabolic processGO:0060068.9TPI1, ALDOC, ENO1
6carbohydrate metabolic processGO:0059757.9LCT, TREH, SI, ENO1, ALDOC, TPI1
7small molecule metabolic processGO:0442817.4LCT, TREH, SI, OTC, ENO1, ALDOC

Products for genes affiliated with Giardiasis

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  • Antibodies
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Sources for Giardiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet