MCID: GRD001
MIFTS: 54

Giardiasis malady

Infectious diseases category

Summaries for Giardiasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards: Giardiasis, also known as infection by giardia lamblia, is related to diarrhea and deficiency anemia. An important gene associated with Giardiasis is TPI1 (triosephosphate isomerase 1), and among its related pathways are Fructose catabolism and Glucose metabolism. The drugs albendazole and metronidazole and the compounds 2-phosphoglycerate and 3-phosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite giardia intestinalis. the symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia:63 Giardiasis (popularly known as beaver fever) is a parasitic disease caused by the flagellate protozoan... more...

Aliases & Classifications for Giardiasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

giardiasis 8 10 44 60
infection by giardia lamblia 8
beaver feaver 8


External Ids:

Disease Ontology8 DOID:10718
ICD9CM27 007.1
MeSH34 D005873
ICD1025 A07.1

Related Diseases for Giardiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Giardiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.3CD79A, LCT, SI
2deficiency anemia30.1CD79A, TPI1
3pancreatitis30.1TGFB1, SCT
4celiac disease30.1GZMB, LCT, CD79A
5lactose intolerance30.0LCT
6irritable bowel syndrome30.0LCT
7urticaria30.0GZMB
8hypothyroidism30.0DNAH8
9pancreatic cancer30.0TGFB1, SCT, ENO1
10thyroiditis29.8CD79A
11inflammatory bowel disease29.8CD79A, TGFB1
12hepatitis29.8GZMB, OTC, TPI1
13myopathy29.8TPI1, DNAH8
14cystic fibrosis29.7OTC, SI, DNAH8, TREH, SCT
15leukemia29.7GZMB, BAG3, DNAH8, OTC, TGFB1, ENO1
16cryptosporidiosis10.5
17duodenitis10.4
18amebiasis10.3
19ascariasis10.2
20trichomoniasis10.1
21iron deficiency anemia10.1
22protein-losing enteropathy10.1
23chronic fatigue syndrome10.1
24intestinal disease10.1
25common variable immunodeficiency10.0
26agammaglobulinemia10.0
27thrombocytopenia10.0CD79A
28duodenal ulcer10.0SCT
29prostatitis10.0CD79A
30interstitial lung disease10.0CD79A
31sarcoidosis10.0GZMB
32alopecia areata10.0GZMB
33schistosomiasis10.0CD79A
34zollinger-ellison syndrome10.0SCT
35epidermolysis bullosa acquisita10.0CD79A
36exanthem10.0CD79A
37lung cancer10.0TGFB1
38infectious mononucleosis10.0CD79A, TPI1
39exocrine pancreatic insufficiency10.0SCT
40pulmonary disease, chronic obstructive10.0TGFB1
41pneumonia10.0CD79A, TGFB1
42glomerulonephritis10.0TGFB1, CD79A
43eye disease10.0TGFB1
44skin disease10.0TGFB1, GZMB
45gingivitis10.0SI
46tuberculosis10.0TPI1, ENO1, CD79A, GZMB
47primary biliary cirrhosis10.0ENO1, CD79A, GZMB, SCT
48glucose intolerance10.0CD79A, LCT, SI
49peptic ulcer10.0DNAH8, SCT
50hepatitis c10.0ENO1, DNAH8

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to giardiasis

Clinical Features for Giardiasis

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Drugs & Therapeutics for Giardiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Giardiasis

Drug clinical trials:

Search ClinicalTrials for Giardiasis

Search NIH Clinical Center for Giardiasis

Search CenterWatch for Giardiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Giardiasis

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Anatomical Context for Giardiasis

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32MalaCards
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MalaCards organs/tissues related to Giardiasis:

32
Small intestine, Testes, Pancreas, Colon, Skin, T cells, Breast, Thyroid, Bone marrow, Liver, Smooth muscle, Bone, B cells

Animal Models for Giardiasis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Giardiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3TGFB1, TPI1, OTC, CD79A, MYLK, TREH

Publications for Giardiasis

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Sources:
50PubMed
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Articles related to Giardiasis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Giardiasis in a patient undergoing chemotherapy for retinoblastoma and acute myelogenous leukemia. (23910805)
2013
2
Severe bilateral anterior uveitis secondary to giardiasis, initially misdiagnosed as a side effect of metronidazole. (23827978)
2013
3
Quantitative microbial risk assessment of cryptosporidiosis and giardiasis from very small private water supplies. (20880218)
2011
4
Lactobacillus rhamnosus GG as an Effective Probiotic for Murine Giardiasis. (21760784)
2011
5
Giardiasis in the pancreas accompanied by pancreatic cancer. (21160381)
2011
6
Study of nonoutbreak giardiasis: novel findings and implications for research. (22014792)
2011
7
Short course combination therapy for giardiasis after nitroimidazole failure. (20595497)
2010
8
Giardiasis, drug resistance, and new target discovery. (20429862)
2010
9
Evaluation of a real-time polymerase chain reaction assay for the laboratory diagnosis of giardiasis. (19903583)
2010
10
High-frequency ultrasound imaging of the duodenum and colon in patients with symptomatic giardiasis in comparison to amebiasis and healthy subjects. (17645477)
2008
11
Sensitivity of a Giardia antigen test in persistent giardiasis following an extensive outbreak. (18808422)
2008
12
Diagnosis of giardiasis by common bile duct brushing cytology. (18702378)
2008
13
The treatment of giardiasis in children: single-dose tinidazole compared with 3 days of nitazoxanide. (18348774)
2008
14
Duodenal appearance of giardiasis in a child with selective immunoglobulin A deficiency. (17532848)
2007
15
Effect of oral chronic intoxication with sodium arsenite on murine giardiasis. (16416670)
2005
16
Incidental giardiasis diagnosed by fine-needle aspiration of a phantom cecal "mass". (16138373)
2005
17
Giardiasis aggravates malabsorption in cystic fibrosis. (15223689)
2004
18
Identification of immunoreactive proteins during acute human giardiasis. (12792861)
2003
19
Giardiasis. (12776040)
2003
20
Giardiasis-associated arthralgia in children. (11471528)
2001
21
Biliary giardiasis in a patient with human immunodeficiency virus. (11468450)
2001
22
Effect of a broad spectrum antiparasitic drug "ivermectin" in acute and chronic experimental giardiasis using different dose regimens. (11478442)
2001
23
Antigiardial and immunostimulatory effect of Piper longum on giardiasis due to Giardia lamblia. (10548746)
1999
24
Outbreak of giardiasis among English tourists in Crete. (9433445)
1998
25
Synovitis secondary to giardiasis in children. (9652890)
1998
26
Efficacy of fenbendazole for treatment of giardiasis in calves. (9099384)
1997
27
Symptoms in patients with giardiasis undergoing upper gastrointestinal endoscopy. (9427489)
1997
28
Giardiasis in native marsupials of Tasmania. (9131575)
1997
29
Efficacy of a combined diloxanide furoate-metronidazole preparation in the treatment of amoebiasis and giardiasis. (9178149)
1997
30
A case of successfully treated giardiasis in pancreas. (9364099)
1997
31
Intestinal lymphangiectasia due to recurrent giardiasis. (8607534)
1996
32
Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis. (8623906)
1996
33
Effect of ivermectin on combined intestinal protozoal infection (giardiasis and cryptosporidiosis). (8918027)
1996
34
Proton-pump inhibition and gastric giardiasis: a causal or casual association? (8963397)
1995
35
Aminosidine sulphate in experimental giardiasis. (7602172)
1995
36
The relation between ABO blood groups, HLA typing and giardiasis in children. (8077760)
1994
37
A randomised multicentre study to compare the safety and efficacy of albendazole and metronidazole in the treatment of giardiasis in children. (7721374)
1994
38
Giardiasis amongst in-and out-patients in Salmaniya Medical Centre in state of Bahrain. (7927584)
1994
39
Diagnosis of giardiasis. (8133633)
1993
40
Efficacy of albendazole against giardiasis in dogs. (8323064)
1993
41
Dermatologic manifestations of giardiasis. (1496900)
1992
42
Giardiasis and municipal water supply. (1876346)
1991
43
Infradian variation in the incidence of giardiasis assessed by linear-nonlinear rhythmometry. (2217313)
1990
44
Lactose-intolerance and hypolactasia in children with giardiasis. (2246732)
1990
45
Serum antibodies to giardial surface antigens: lower titres in persistent than in non-persistent giardiasis. (2585473)
1989
46
Detection of specific anti-giardia serum antibody by an immunofluorescence test in children with clinical giardiasis. (2658636)
1989
47
Diagnosis of giardiasis in infants and children by endoscopic brush cytology. (2651633)
1989
48
Dietary fiber and giardiasis: dietary fiber reduces rate of intestinal infection by Giardia lamblia in the gerbil. (2554737)
1989
49
An outbreak of giardiasis in a nursing home with evidence for multiple modes of transmission. (2760485)
1989
50
Apparent protein-losing enteropathy associated with giardiasis. (7416119)
1980

Genetic Variations for Giardiasis

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Expression for genes affiliated with Giardiasis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for genes affiliated with Giardiasis

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Giardiasis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3ALDOC, SI
2
Hide members
9.2ENO1, ALDOC, TPI1
39.1LCT, SI, TREH
4
Hide members
8.8ENO1, OTC, ALDOC, TPI1
5
Hide members
8.5OTC, SI, ENO1, ALDOC, TPI1
6
Hide members
7.8ALDOC, LCT, TREH, SI, ENO1, TPI1

Compounds for genes affiliated with Giardiasis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 11DrugBank
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Compounds related to Giardiasis according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
12-phosphoglycerate4410.4TPI1, ENO1
23-phosphoglycerate4410.3TPI1, ENO1
3pneumococcal4410.2ENO1, CD79A
4lactulose4410.1SI, CD79A
5butyrate4410.1OTC, SI
6phlorizin44 28 5912.0LCT, SI
7oxygen44 2411.0SI
8gliadin4410.0SI, CD79A
9ramipril44 1110.9CD79A, TGFB1
102,3-butanedione monoxime449.9MYLK, DNAH8
11phosphoenolpyruvate44 1110.9SI, OTC, ENO1
12malate449.8OTC, DNAH8, TPI1
13scopolamine44 28 11 2412.7SI, DNAH8
14pmma449.7TGFB1, CD79A
15carnitine449.7CD79A, OTC, DNAH8
16pyruvate449.7TPI1, ENO1, OTC, SI
17prednisolone44 28 1111.6CD79A, DNAH8, GZMB
18glutaraldehyde449.6TGFB1, DNAH8, CD79A
19estrogen449.6SI, CD79A
20clonidine44 28 1111.5SCT, DNAH8, TGFB1
21theophylline44 28 11 2412.5TGFB1, CD79A, DNAH8
224-hydroxynonenal44 2410.5ENO1, TGFB1, DNAH8
23hyaluronic acid44 2410.5CD79A, TGFB1, GZMB
24fatty acid449.5TPI1, ENO1, SI, OTC
25thyroxine44 2410.3SCT, DNAH8, TGFB1, CD79A
26paraffin449.3TGFB1, GZMB, SI, CD79A
27indomethacin44 59 28 1112.3SCT, TGFB1, CD79A, DNAH8
28carbon449.3TREH, SI, TPI1
29glycerol44 11 2411.2LCT, DNAH8, CD79A, OTC, TPI1
30polysaccharide449.1TGFB1, CD79A, DNAH8, SI
31cyclosporin a44 28 5911.0SCT, CD79A, TGFB1, GZMB, DNAH8
32creatinine448.8OTC, CD79A, DNAH8, ENO1, TGFB1, TPI1
33aspartate448.8SCT, SI, DNAH8, MYLK, OTC, TPI1
34lipid448.8TPI1, ENO1, OTC, SI, SCT, LCT
35retinoic acid44 249.7ENO1, DNAH8, SCT, GZMB, TGFB1, CD79A
36lactate448.7GZMB, TGFB1, TPI1, ENO1, OTC, CD79A
37glutamine448.6TGFB1, ENO1, OTC, SCT, DNAH8, SI
38arginine448.6OTC, DNAH8, CD79A, SI, GZMB, SCT
39atp44 289.6SCT, GZMB, MYLK, DNAH8, OTC, ENO1
40hydrogen44 249.5TPI1, SI, DNAH8, TREH, SCT, LCT
41cysteine448.4DNAH8, LCT, TPI1, GZMB, SI, CD79A
42glutamate448.4GZMB, DNAH8, TPI1, MYLK, ENO1, OTC
43alanine447.9GZMB, MYLK, CD79A, DNAH8, SI, TGFB1
44glucose447.8ENO1, SCT, LCT, GZMB, TREH, TPI1

GO Terms for genes affiliated with Giardiasis

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16Gene Ontology
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Biological processes related to Giardiasis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1polysaccharide digestionGO:0442459.3LCT, SI, TREH
2gluconeogenesisGO:0060949.2TPI1, ALDOC, ENO1
3glycolysisGO:0060969.2ENO1, ALDOC, TPI1
4positive regulation of cell migrationGO:0303359.1SYNE2, MYLK, TGFB1
5glucose metabolic processGO:0060068.9TPI1, ALDOC, ENO1
6carbohydrate metabolic processGO:0059757.9TPI1, LCT, TREH, SI, ENO1, ALDOC
7small molecule metabolic processGO:0442817.4TREH, SI, OTC, ENO1, ALDOC, TPI1

Products for genes affiliated with Giardiasis

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Sources for Giardiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet