MCID: GRD001
MIFTS: 57

Giardiasis malady

Infectious diseases category
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Summaries for Giardiasis

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CDC:3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards based summary: Giardiasis, also known as infection by giardia lamblia, is related to diarrhea and lactose intolerance. An important gene associated with Giardiasis is TPI1 (triosephosphate isomerase 1), and among its related pathways are Glucose metabolism and MPS VI - Maroteaux-Lamy syndrome. The drugs metronidazole and metronidazole hydrochloride and the compounds 2-phosphoglycerate and 3-phosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite giardia intestinalis. the symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia:65 Giardiasis (popularly known as beaver fever) is a zoonotic parasitic disease caused by the flagellate... more...

Aliases & Classifications for Giardiasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Giardiasis, Aliases & Descriptions:

Name: Giardiasis 8 10 44 62
Infection by Giardia Lamblia 8 62
 
Beaver Feaver 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:10718
MeSH34 D005873
ICD9CM27 007.1
ICD1025 A07.1

Related Diseases for Giardiasis

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Diseases related to Giardiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.5LCT, CD79A
2lactose intolerance30.5LCT
3celiac disease30.4CD79A, GZMB, LCT
4hepatitis30.1TGFB1, GZMB
5inflammatory bowel disease30.1CD79A, TGFB1
6pancreatic cancer30.1SCT, TGFB1, ENO1
7cystic fibrosis30.0DNAH8, SCT
8leukemia29.2TGFB1, DNAH8, GZMB, ENO1, CD79A
9cryptosporidiosis10.5
10exanthem10.5CD79A
11epidermolysis bullosa acquisita10.5CD79A
12duodenitis10.5
13exocrine pancreatic insufficiency10.5SCT
14zollinger-ellison syndrome10.5SCT
15infectious mononucleosis10.4TPI1, CD79A
16amebiasis10.3
17measles10.3CD79A, SCT
18glucose intolerance10.2LCT, CD79A
19ascariasis10.2
20helminthiasis10.2
21lupus nephritis10.2TGFB1, CD79A
22glomerulosclerosis10.2CD79A, TGFB1
23berger disease10.2TGFB1, CD79A
24connective tissue disease10.2TGFB1, CD79A
25skin disease10.2TGFB1, GZMB
26sjogren's syndrome10.2CD79A, GZMB
27deficiency anemia10.2
28common variable immunodeficiency10.2
29trichomoniasis10.2
30iron deficiency anemia10.2
31protein-losing enteropathy10.2
32pancreatitis10.2
33systemic lupus erythematosus10.2CD79A, ENO1, TPI1
34ulcerative colitis10.1CD79A, ENO1, GZMB
35vasculitis10.1CD79A, ENO1
36intrahepatic cholestasis10.1DNAH8, SCT
37gastroesophageal reflux disease10.1DNAH8, SCT
38peptic ulcer disease10.1DNAH8, SCT
39irritable bowel syndrome10.1
40chronic fatigue syndrome10.1
41agammaglobulinemia10.1
42hypothyroidism10.1
43intestinal disease10.1
44urticaria10.1
45pancreatitis, chronic10.1TGFB1, SCT
46tuberculosis10.0TPI1, GZMB, ENO1, CD79A
47dermatitis10.0CD79A, GZMB
48primary biliary cirrhosis10.0SCT, GZMB, ENO1, CD79A
49gastritis10.0SCT, DNAH8, CD79A
50herpes simplex10.0DNAH8, ENO1, CD79A

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to giardiasis

Symptoms for Giardiasis

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Drugs & Therapeutics for Giardiasis

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Drug clinical trials:

Search ClinicalTrials for Giardiasis

Search NIH Clinical Center for Giardiasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Giardiasis

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Anatomical Context for Giardiasis

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MalaCards organs/tissues related to Giardiasis:

32
Small intestine, Testes, Pancreas, Colon, Skin, Bone marrow, Bone, Smooth muscle, Liver, Thyroid, Breast, T cells, B cells

Animal Models for Giardiasis or affiliated genes

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MGI Mouse Phenotypes related to Giardiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.9CD79A, GZMB, MYLK, TGFB1, TPI1
2MP:00053767.2CD79A, SCT, TPI1, TGFB1, MYLK, GZMB

Publications for Giardiasis

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Articles related to Giardiasis:

(show top 50)    (show all 521)
idTitleAuthorsYear
1
Resistance to reinfection in mice as a vaccine model for giardiasis. (24805818)
2014
2
Giardiasis in a patient undergoing chemotherapy for retinoblastoma and acute myelogenous leukemia. (23910805)
2013
3
Secnidazole for the treatment of giardiasis in naturally infected cats. (21763779)
2011
4
Mebendazole compared with secnidazole in the treatment of adult giardiasis: a randomised, no-inferiority, open clinical trial. (22174992)
2011
5
Risk factors for endemic giardiasis: highlighting the possible association of contaminated water and food. (18377940)
2008
6
Survey of feline giardiasis by ELISA test in Italy. (17195926)
2007
7
Investigation of potential zooanthroponotic transmission of cryptosporidiosis and giardiasis through agricultural use of reclaimed wastewater. (17164167)
2006
8
Risk of giardiasis associated with water supply in an endemic context. (16990176)
2006
9
Giardiasis surveillance--United States, 1998-2002. (15674189)
2005
10
Determinants of the geographical distribution of endemic giardiasis in Ontario, Canada: a spatial modelling approach. (15473161)
2004
11
Albendazole as an alternative therapeutic agent for childhood giardiasis in Turkey. (15191380)
2004
12
Prevalence of Giardiasis due to wastewater reuse for agriculture in the suburbs of Asmara City, Eritrea. (14660117)
2004
13
Antitransglutaminase antibodies and giardiasis. (15571608)
2004
14
Symptomatic giardiasis without diarrhea: further evidence to support the routine duodenal biopsy? (12838238)
2003
15
Geographical and temporal distribution of human giardiasis in Ontario, Canada. (12946275)
2003
16
Giardiasis treatment in Turkish children with a single dose of ornidazole. (12587625)
2002
17
Risk of giardiasis in Aucklanders: a case-control study. (12718834)
2002
18
Neuroblastoma with concomitant giardiasis: report of a case with diagnosis by fine needle aspiration cytology. (11575653)
2001
19
Giardiasis-associated arthralgia in children. (11471528)
2001
20
Serum vitamin A and beta-carotene levels in children with giardiasis before and after treatment. (9718915)
1998
21
Efficacy of a drug combination of praziquantel, pyrantel pamoate, and febantel against giardiasis in dogs. (9736391)
1998
22
A study on the relation between proton pump inhibitor and gastric giardiasis. (9617051)
1998
23
Efficacy of fenbendazole for treatment of giardiasis in calves. (9099384)
1997
24
Case in point. Small bowel giardiasis. (9307595)
1997
25
Symptoms in patients with giardiasis undergoing upper gastrointestinal endoscopy. (9427489)
1997
26
Intestinal lymphangiectasia due to recurrent giardiasis. (8607534)
1996
27
Single-dose secnidazole versus 10-day metronidazole therapy of giardiasis in Iranian children. (8699592)
1996
28
Giardiasis. (8863037)
1996
29
A comparative clinical trial of albendazole versus metronidazole in giardiasis. (8613282)
1995
30
Secnidazole in the treatment of giardiasis. (8714630)
1995
31
Human giardiasis. A morphometric study of duodenal biopsy specimens in relation to the trophozoite count in the duodenal aspirate. (8080358)
1994
32
Evaluation of the immune response in symptomatic and asymptomatic human giardiasis. (7919807)
1994
33
The relation between ABO blood groups, HLA typing and giardiasis in children. (8077760)
1994
34
Prevalence of giardiasis among primary school children. (7955135)
1994
35
Efficacy of fenbendazole against giardiasis in dogs. (7978640)
1994
36
Peculiar histopathological features of giardiasis in distal duodenal biopsies. (7799507)
1994
37
Treating possible giardiasis. (8304864)
1993
38
Diarrhoea and malabsorption in giardiasis: a multifactorial process? (1568645)
1992
39
Factors associated with acquiring giardiasis in British Columbia residents. (1617559)
1992
40
Gastric giardiasis. (1452790)
1992
41
Lack of an association between endemic giardiasis and a drinking water source. (1473069)
1992
42
Giardiasis--a simple diagnosis that is often delayed. (1950049)
1991
43
Modification of RPMI 1640 for use in vitro immunological studies of host-parasite interactions in giardiasis. (2037682)
1991
44
Giardiasis and amoebiasis infections in three Saudi closed communities. (1995937)
1991
45
Pruritus without urticaria in acute giardiasis. (2382876)
1990
46
Severe giardiasis in two patients undergoing bone marrow transplantation. (2819289)
1989
47
Severe giardiasis in a child during cancer therapy. (2929575)
1989
48
Fever and urticaria in acute giardiasis. (2705846)
1989
49
Retinal arteritis, iridocyclitis, and giardiasis. (6891764)
1982
50
Giardiasis, isosporiasis and balantidiasis. (627102)
1978

Variations for Giardiasis

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Expression for genes affiliated with Giardiasis

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Expression patterns in normal tissues for genes affiliated with Giardiasis

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Pathways for genes affiliated with Giardiasis

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Compounds for genes affiliated with Giardiasis

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Compounds related to Giardiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
12-phosphoglycerate4410.2TPI1, ENO1
23-phosphoglycerate4410.2ENO1, TPI1
3pneumococcal4410.1CD79A, ENO1
4isocitrate4410.0TPI1, ENO1
5aldose449.9TPI1, ENO1
6concanamycin a44 6110.8GZMB, DNAH8
72,3-butanedione monoxime449.7DNAH8, MYLK
8ramipril44 1110.6CD79A, TGFB1
9pmma449.6CD79A, TGFB1
10fluoride449.6CD79A, DNAH8
11actomyosin449.6MYLK, DNAH8
12prednisolone44 28 1111.5DNAH8, GZMB, CD79A
13epinephrine44 24 1111.5CD79A, DNAH8, SCT
14phosphatidylserine44 28 1111.5DNAH8, GZMB, CD79A
15omeprazole44 50 28 24 1113.4DNAH8, SCT
16norepinephrine44 24 1111.4CD79A, DNAH8, SCT
17trifluoperazine44 28 50 1112.3DNAH8, MYLK
18acetylcholine44 50 28 24 1113.3SCT, DNAH8, CD79A
19glutaraldehyde449.2CD79A, DNAH8, TGFB1
20hyaluronic acid44 2410.2TGFB1, GZMB, CD79A
21tacrolimus44 50 1111.2CD79A, GZMB, TGFB1
22glycerol44 24 1111.2TPI1, DNAH8, LCT, CD79A
23theophylline44 28 24 1112.2CD79A, DNAH8, TGFB1
244-hydroxynonenal44 2410.2ENO1, DNAH8, TGFB1
25clonidine44 50 28 1112.1DNAH8, TGFB1, SCT
26rantes449.1SCT, TGFB1, GZMB
27hydrogen44 2410.1SCT, TPI1, DNAH8, LCT
28polysaccharide449.1TGFB1, DNAH8, CD79A
29histamine44 28 2411.0CD79A, TGFB1, SCT
30alginate449.0CD79A, TGFB1
31etoposide44 50 61 1112.0TGFB1, DNAH8, GZMB
32oxygen44 2410.0ENO1, GZMB, MYLK, TPI1
33thyroxine44 249.8CD79A, DNAH8, TGFB1, SCT
34indomethacin44 28 61 1111.8SCT, TGFB1, DNAH8, CD79A
35arginine448.8SCT, DNAH8, GZMB, ENO1, CD79A
36lipid448.8SCT, TPI1, LCT, GZMB, ENO1
37glutamine448.7SCT, TGFB1, DNAH8, ENO1
38lactate448.6TPI1, TGFB1, GZMB, ENO1, CD79A
39creatinine448.5TPI1, TGFB1, DNAH8, ENO1, CD79A
40estrogen448.4TGFB1, MYLK, GZMB, CD79A
41cyclosporin a44 28 6110.4SCT, TGFB1, DNAH8, GZMB, CD79A
42aspartate448.2SCT, TPI1, MYLK, DNAH8, GZMB, ENO1
43atp44 289.2SCT, TPI1, MYLK, DNAH8, GZMB, ENO1
44glucose448.2SCT, TPI1, MYLK, LCT, GZMB, ENO1
45alanine448.1TGFB1, MYLK, DNAH8, GZMB, CD79A
46retinoic acid44 249.0SCT, TGFB1, DNAH8, GZMB, ENO1, CD79A
47cysteine448.0SCT, TPI1, DNAH8, LCT, GZMB, ENO1
48calcium44 50 24 1110.9SCT, MYLK, DNAH8, LCT, GZMB, ENO1
49serine447.9SCT, TPI1, TGFB1, MYLK, GZMB, ENO1
50glutamate447.9CD79A, SCT, TPI1, MYLK, DNAH8, GZMB

GO Terms for genes affiliated with Giardiasis

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Biological processes related to Giardiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycolytic processGO:0060969.8ENO1, TPI1
2gluconeogenesisGO:0060949.5ENO1, TPI1
3carbohydrate metabolic processGO:0059759.2ENO1, LCT, TPI1

Products for genes affiliated with Giardiasis

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Sources for Giardiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet