MCID: GGN002
MIFTS: 30

Gigantism malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases

Aliases & Classifications for Gigantism

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Aliases & Descriptions for Gigantism:

Name: Gigantism 45 47 65

Classifications:



External Ids:

UMLS65 C0017547

Summaries for Gigantism

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NIH Rare Diseases:45 Gigantism is abnormally large growth due to an excess of growth hormone (gh) during childhood, before the bone growth plates have closed (epiphyseal fusion). it causes excessive growth in height, muscles, and organs, making the child extremely large for age. other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness. it may begin at any age before epiphyseal fusion. the most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much gh, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including carney complex; mccune-albright syndrome (mas); multiple endocrine neoplasia type 1 (men-1); and neurofibromatosis. treatment typically includes surgery to remove the tumor and can cure many cases. medication or radiation therapy may be used to reduce gh release or block the effect of gh. if the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly. last updated: 12/10/2010

MalaCards based summary: Gigantism is related to gigantism advanced bone age hoarse cry and acromegaly. An important gene associated with Gigantism is AIP (Aryl Hydrocarbon Receptor Interacting Protein). Affiliated tissues include pituitary, bone and liver.

Wikipedia:68 Gigantism, also known as giantism (from Greek γίγας gigas, \"giant\", plural γίγαντες... more...

Related Diseases for Gigantism

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Diseases in the Gigantism family:

Familial Infantile Gigantism

Diseases related to Gigantism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 334)
idRelated DiseaseScoreTop Affiliating Genes
1gigantism advanced bone age hoarse cry31.7AIP, GHRH, GPC3, GPR101, PRL
2acromegaly31.2AIP, GHRH, PRL
3pituitary adenoma29.9GHRH, PRL
4functioning pituitary adenoma29.6AIP, PRL
5familial infantile gigantism12.5
6pituitary gigantism12.5
7cerebral gigantism jaw cysts12.3
8sotos syndrome 112.0
9perlman syndrome11.9
10beckwith-wiedemann syndrome11.8
11simpson-golabi-behmel syndrome, type 111.6
12proteus syndrome, somatic11.5
13simpson-golabi-behmel syndrome11.5
14lipodystrophy, congenital generalized, type 211.4
15x-linked acrogigantism due to xq26 microduplication11.4
16ehlers-danlos syndrome, type vi11.2
17lipodystrophy, congenital generalized, type 111.2
18macrocephaly mesodermal hamartoma spectrum11.2
19x-linked acrogigantism due to a point mutation11.2
20pituitary adenoma, growth hormone-secreting10.4
21cerebritis10.3
22cowden syndrome 110.3
23mccune-albright syndrome, somatic, mosaic10.3
24simpson-golabi-behmel syndrome, type 210.3
25pituitary adenoma, growth hormone-secreting 210.3
26lung cancer10.2
27pancreatitis10.2
28thyroiditis10.2
29breast cancer10.2
30leukemia10.2
31neuronitis10.2
32endotheliitis10.2
33hepatitis10.1
34lymphoma10.1
35prostatitis10.1
36ischemia10.1
37retinitis10.1
38tuberculosis10.1
39adrenal gland hyperfunction10.1GHRH, PRL
40schizophrenia10.1
41rheumatoid arthritis10.1
42prostate cancer10.1
43arthritis10.1
44sarcoma10.1
45melanoma10.1
46adenocarcinoma10.1
47adenoma10.1
48neurofibromatosis10.1
49hypoxia10.1
50primary hypertrophic osteoarthropathy10.1GHRH, PRL

Graphical network of the top 20 diseases related to Gigantism:



Diseases related to gigantism

Symptoms for Gigantism

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Drugs & Therapeutics for Gigantism

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Drugs for Gigantism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver ExtractsPhase 43572
2
SomatostatinPhase 415351110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
3lanreotidePhase 474
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
5Hormone AntagonistsPhase 410002
6HormonesPhase 411748
7AngiopeptinPhase 474

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.CompletedNCT01861717Phase 4
2Efficacy and Safety of Pasireotide LAR in Japanese Patients With Acromegaly or Pituitary GigantismActive, not recruitingNCT01673646Phase 2
3Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPARecruitingNCT00461188
4Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education ToolsRecruitingNCT01775332

Search NIH Clinical Center for Gigantism

Genetic Tests for Gigantism

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Anatomical Context for Gigantism

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MalaCards organs/tissues related to Gigantism:

33
Pituitary, Bone, Liver, Breast, T cells, Endothelial, Kidney

Animal Models for Gigantism or affiliated genes

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Publications for Gigantism

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Articles related to Gigantism:

(show top 50)    (show all 443)
idTitleAuthorsYear
1
Steady increase of lymphogranuloma venereum cases, Czech Republic, 2010 to 2015. (27020297)
2016
2
Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. (25936917)
2015
3
Primary gastric choriocarcinoma: A rare case. (26218175)
2015
4
Alternating hemiplegia of childhood: ATP1A3 gene analysis in 16 patients]. (24768197)
2014
5
Three-dimensional echocardiographic reconstruction of double-orifice mitral valve and mitral leaflet prolapse. (25210099)
2014
6
Next-generation sequencing identifies rare variants associated with Noonan syndrome. (25049390)
2014
7
Hand surface landmarks and measurements in the treatment of trigger thumb. (23591023)
2013
8
The association between LRP-1 variants and chylomicron uptake after a high fat meal. (23484911)
2013
9
Dementia with lewy bodies: a comprehensive review for nurses. (24217145)
2013
10
Methemoglobinemia in the setting of chronic transdermal lidocaine patch use. (22568708)
2012
11
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. (22046234)
2011
12
Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis. (19538200)
2010
13
Do children with adenotonsillar hypertrophy have lower IGF-1 and ghrelin levels than the normal children? (20394991)
2010
14
Expression and regulation of tumor necrosis factor (TNF) and TNF-receptor family members in the macaque corpus luteum during the menstrual cycle. (18932199)
2009
15
The T allele of the 677C>T polymorphism of methylenetetrahydrofolate reductase gene is associated with an increased risk of ischemic stroke in Polish children. (19805823)
2009
16
NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. (18323857)
2008
17
Cleft palate cells can regenerate a palatal mucosa in vitro. (18650554)
2008
18
Early gene expression in human lymphocytes after gamma-irradiation-a genetic pattern with potential for biodosimetry. (18464067)
2008
19
Giant Cholesteatoma: Recommendations for Follow-up. (19240835)
2008
20
Human VRK1 is an early response gene and its loss causes a block in cell cycle progression. (18286197)
2008
21
Hemicraniectomy for middle cerebral artery infarction. (18957191)
2008
22
Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients. (17360956)
2007
23
Physiologically high concentrations of 17beta-estradiol enhance NF-kappaB activity in human T cells. (17194723)
2007
24
A preliminary assessment of vitamin K1 intakes and serum undercarboxylated osteocalcin levels in 11-13 year old Irish girls. (17607958)
2006
25
Juvenile hyaline fibromatosis: a case report. (17183860)
2006
26
Molecular basis of the JAHK (RH53) antigen. (16078918)
2005
27
Structural features of GR6 gene and its expression in colorectal neoplasm]. (15067727)
2004
28
Characterization of glutathione conjugates of the remoxipride hydroquinone metabolite NCQ-344 formed in vitro and detection following oxidation by human neutrophils. (15089099)
2004
29
Autoimmune progesterone dermatitis presenting with purpura and petechiae. (15115523)
2004
30
Plagiocephaly: morphometry of skull base asymmetry. (14504821)
2003
31
Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin. (12857907)
2003
32
Acetohydroxyacid synthase from Mycobacterium avium and its inhibition by sulfonylureas and imidazolinones. (12818195)
2003
33
Future directions in the treatment of IgA nephropathy. (12218302)
2002
34
Renal involvement in a patient with idiopathic hypereosinophilic syndrome. (11863130)
2002
35
Altered nucleotide misinsertion fidelity associated with poliota- dependent replication at the end of a DNA template. (11387224)
2001
36
Cauda equina syndrome secondary to idiopathic spinal epidural lipomatosis. (11224868)
2001
37
Possible diagnostic role of telomerase activity evaluation in the differential diagnosis between spitz naevi and cutaneous malignant melanoma. (10809882)
2000
38
IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. (9886425)
1999
39
Simultaneous determination of NK-104 and its lactone in biological samples by column-switching high-performance liquid chromatography with ultraviolet detection. (10202970)
1999
40
Tamoxifen and hypertriglyceridemia. (10474278)
1999
41
CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment. (10363932)
1999
42
Expression of the multidrug resistance protein (MRP) in squamous cell carcinoma of the oesophagus and response to pre-operative chemotherapy. (9624242)
1998
43
Mechanisms and management of acute renal allograft rejection. (9531937)
1998
44
Hemolytic anemias due to erythrocyte enzyme deficiencies. (8813716)
1996
45
Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR. (8732688)
1996
46
Tissue-specific and developmentally regulated expression of human elastin promoter activity in transgenic mice. (8027067)
1994
47
Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes. (2094803)
1990
48
Development of focal glomerulosclerosis after unilateral nephrectomy in infant rats. (3153291)
1987
49
Restrictive cardiomyopathy in scleroderma. (6726049)
1984
50
Cerebral argyria after hibernation. (5692343)
1968

Variations for Gigantism

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Expression for genes affiliated with Gigantism

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Search GEO for disease gene expression data for Gigantism.

Pathways for genes affiliated with Gigantism

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GO Terms for genes affiliated with Gigantism

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Biological processes related to Gigantism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00072679.3GHRH, GPR101

Sources for Gigantism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet