Aliases & Classifications for Gigantism

About this section

Aliases & Descriptions for Gigantism:

Name: Gigantism 46 48 66

Classifications:



Summaries for Gigantism

About this section
NIH Rare Diseases:46 Gigantism is abnormally large growth due to an excess of growth hormone (gh) during childhood, before the bone growth plates have closed (epiphyseal fusion). it causes excessive growth in height, muscles, and organs, making the child extremely large for age. other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness. it may begin at any age before epiphyseal fusion. the most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much gh, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including carney complex; mccune-albright syndrome (mas); multiple endocrine neoplasia type 1 (men-1); and neurofibromatosis. treatment typically includes surgery to remove the tumor and can cure many cases. medication or radiation therapy may be used to reduce gh release or block the effect of gh. if the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly. last updated: 12/10/2010

MalaCards based summary: Gigantism is related to lymphedema and cerebral gigantism jaw cysts, and has symptoms including endocrine system signs and symptoms An important gene associated with Gigantism is AIP (Aryl Hydrocarbon Receptor Interacting Protein). Affiliated tissues include pituitary, bone and breast.

Wikipedia:69 Gigantism, also known as giantism (from Greek γίγας gigas, \"giant\", plural γίγαντες... more...

Related Diseases for Gigantism

About this section

Diseases related to Gigantism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1lymphedema29.6IGF1, SST
2cerebral gigantism jaw cysts11.9
3gigantism advanced bone age hoarse cry11.9
4perlman syndrome11.7
5pituitary adenoma, growth hormone-secreting11.6
6beckwith-wiedemann syndrome11.6
7sotos syndrome 111.6
8chromosome xq26.3 duplication syndrome11.5
9simpson-golabi-behmel syndrome, type 111.3
10acromegaly11.1
11proteus syndrome, somatic11.1
12lipodystrophy, congenital generalized, type 211.0
13simpson-golabi-behmel syndrome11.0
14ehlers-danlos syndrome, type vi10.8
15lipodystrophy, congenital generalized, type 110.8
16macrocephaly mesodermal hamartoma spectrum10.8
17x-linked acrogigantism due to a point mutation10.8
18cerebritis10.5
19prolactinoma10.3IGF1, SST
20osseous heteroplasia, progressive10.2AIP, IGF1
21postural hypotension10.2IGF1, SST
22tropical sprue10.2IGF1, SST
23sost-related sclerosing bone dysplasia10.2IGF1, SST
24mobitz type ii atrioventricular block10.2AIP, SST
25cold-induced sweating syndrome 210.2AIP, SST
26laryngeal carcinoma10.2IGF1, SST
27adenoma10.2
28neuropathy, hereditary sensory and autonomic, type vi10.2IGF1, SST
29lipoadenoma10.2AIP, SST
30alpha-methylacyl-coa racemase deficiency10.1IGF1, SST
31gestational choriocarcinoma10.1IGF1, SST
32short bowel syndrome10.1IGF1, SST
33macroglossia10.1
34alveoli adenoma10.1IGF1, SST
35diabetes insipidus10.1GHRH, IGF1
36renal pelvis adenocarcinoma10.1GHRH, SST
37growth retardation hydrocephaly lung hypoplasia10.1GHRH, IGF1
38peripheral epithelioid sarcoma10.1GHRH, SST
39glucosidase acid-1,4-alpha deficiency10.1GHRH, SST
40pituitary adenoma10.1
41neurofibromatosis10.1
42femoral neuropathy10.0IGF1, SST
43adrenal carcinoma10.0GHRH, SST
44survival motor neuron spinal muscular atrophy10.0IGF1, SST
45fibrous dysplasia10.0
46hyperprolactinemia9.9
47immunodeficiency, common variable, 59.9GHRH, SST
48hypertrichosis9.9IGF1, SST
49third cranial nerve disease9.9IGF1, SST
50lymphoma9.9

Graphical network of the top 20 diseases related to Gigantism:



Diseases related to gigantism

Symptoms for Gigantism

About this section

UMLS symptoms related to Gigantism:


endocrine system signs and symptoms

Drugs & Therapeutics for Gigantism

About this section

Drugs for Gigantism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinPhase 421238916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2
lanreotidePhase 479108736-35-2
Synonyms:
Lanreotide
 
Lanreotide acetate
Somatuline Depot

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.CompletedNCT01861717Phase 4
2Efficacy and Safety of Pasireotide LAR in Japanese Patients With Acromegaly or Pituitary GigantismActive, not recruitingNCT01673646Phase 2
3Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPARecruitingNCT00461188
4Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education ToolsRecruitingNCT01775332

Search NIH Clinical Center for Gigantism

Genetic Tests for Gigantism

About this section

Anatomical Context for Gigantism

About this section

MalaCards organs/tissues related to Gigantism:

34
Pituitary, Bone, Breast, Liver, Hypothalamus, Colon, B cells

Animal Models for Gigantism or affiliated genes

About this section

Publications for Gigantism

About this section

Articles related to Gigantism:

(show top 50)    (show all 459)
idTitleAuthorsYear
1
Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome. (26607152)
2016
2
Giants among larges: how gigantism impacts giant virus entry into amoebae. (27039270)
2016
3
Benign or Malignant? Two Case Reports of Gigantic Prostatic Cyst. (27500085)
2016
4
Pituitary gigantism: update on molecular biology and management. (26574647)
2015
5
Ecological explanations to island gigantism: dietary niche divergence, predation, and size in an endemic lizard. (26405734)
2015
6
Localised gigantism. (25849020)
2015
7
Rare gigantic giant cell tumor of anterior ribs in a young lady. (25767344)
2014
8
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. (25470569)
2014
9
Herbivory and body size: allometries of diet quality and gastrointestinal physiology, and implications for herbivore ecology and dinosaur gigantism. (24204552)
2013
10
The Perlman syndrome: familial renal dysplasia with Wilms tumor, fetal gigantism and multiple congenital anomalies. (24166810)
2013
11
Pituitary gigantism: a case report. (23565401)
2012
12
Unusual bone scan finding: gigantic hepatic hemangioma visualized on bone scintigraphy. (23293797)
2012
13
Gigantic intrapericardial bronchogenic cyst. (21625867)
2011
14
Can oxygen set thermal limits in an insect and drive gigantism? (21818347)
2011
15
Reduced predator species richness drives the body gigantism of a frog species on the Zhoushan Archipelago in China. (20840555)
2011
16
Acromegaly and gigantism in the medical literature. Case descriptions in the era before and the early years after the initial publication of Pierre Marie (1886). (18683056)
2009
17
Convergent evolution of gigantism in damselflies of Africa and South America? Evidence from nuclear and mitochondrial sequence data. (16945555)
2007
18
Cyclin-dependent kinase inhibitor gene polymorphisms in pituitary gigantism. (16622299)
2006
19
Macrodactyly, syndactyly, and localized gigantism of the forefoot. A case report. (16878777)
2005
20
Pegvisomant therapy in pituitary gigantism: successful treatment in a 12-year-old girl. (16061823)
2005
21
Clinical report of congenital lymphatic malformations and partial gigantism of the hands associated with a heterogeneous karyotype. (15472995)
2005
22
Gigantism and comparative life-history parameters of tyrannosaurid dinosaurs. (15306807)
2004
23
Genomic gigantism: DNA loss is slow in mountain grasshoppers. (11158383)
2001
24
Gigantism. (10599691)
1999
25
Pyodermia chronica glutealis complicated by acromegalic gigantism. (9609982)
1998
26
Optic pathway glioma infiltrating into somatostatinergic pathways in a young boy with gigantism. Case report. (7931594)
1994
27
Pathological and experimental investigations in a case of gigantism. (8382895)
1993
28
Pituitary gigantism caused by growth hormone excess from infancy. (1593354)
1992
29
Expression of metallothionein-human growth hormone fusion genes in transgenic mice results in disproportionate skeletal gigantism. (1938045)
1991
30
Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene. (1848356)
1991
31
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
32
Perlman syndrome: familial renal dysplasia with Wilms tumor, fetal gigantism, and multiple congenital anomalies. (3024486)
1986
33
A new X-linked dysplasia gigantism syndrome: identical with the Simpson dysplasia syndrome? (6490008)
1984
34
The dynamic of impaired glucose tolerance in women with fetal gigantism. (6369499)
1984
35
Cognition in cerebral gigantism: are the estimates of mental retardation too high? (6662920)
1983
36
The acromegaly--gigantism syndrome. Report of four cases treated surgically. (6648790)
1983
37
Cerebral gigantism, intestinal polyposis, and pigmentary spotting of the genitalia. (6859117)
1983
38
Unilateral delayed opercularization in a case of Sotos' syndrome (Cerebral Gigantism). (7422120)
1980
39
Acromegalic gigantism and tuberous sclerosis. (211218)
1978
40
Breast gigantism with penicillamine therapy. (623688)
1978
41
Fractionation studies on plasma of normals and patients with Laron dwarfism and hypopituitary gigantism. (4762432)
1973
42
Hypothalamic gigantism. (4199040)
1973
43
Induction and Ecological Significance of Gigantism in the Rotifer Asplanchna sieboldi. (17769827)
1973
44
Exomphalos-macroglossia-gigantism syndrome in Jamaican infants. (5434588)
1970
45
Chediak-Higashi syndrome: hereditary gigantism of cytoplasmic organelles. (5908967)
1966
46
Cerebral gigantism. (5832155)
1965
47
Acromegalic gigantism. The Buffalo giant. (14488703)
1961
48
The gigantism produced in normal rats by injection of the pituitary growth hormone; main chemical components of the body. (18871178)
1948
49
Interrelationship between pituitary growth factor and growth-promoting androgens in acromegaly and gigantism; quantitative evaluation of bone and soft tissue growth in acromegaly and gigantism. (18109112)
1948
50
The gigantism produced in normal rats by injection of the pituitary growth hormone; body growth and organ changes. (18871176)
1948

Variations for Gigantism

About this section

Expression for genes affiliated with Gigantism

About this section
Search GEO for disease gene expression data for Gigantism.

Pathways for genes affiliated with Gigantism

About this section

GO Terms for genes affiliated with Gigantism

About this section

Biological processes related to Gigantism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.6GHRH, IGF1
2response to nutrientGO:00075849.3IGF1, SST
3response to heatGO:00094089.1IGF1, SST
4cell-cell signalingGO:00072678.9GHRH, GPR101, SST

Molecular functions related to Gigantism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.1IGF1, SST

Sources for Gigantism

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet