Aliases & Classifications for Gigantism

Aliases & Descriptions for Gigantism:

Name: Gigantism 50 52 69

Classifications:



Summaries for Gigantism

NIH Rare Diseases : 50 gigantism is abnormally large growth due to an excess of growth hormone (gh) during childhood, before the bone growth plates have closed (epiphyseal fusion). it causes excessive growth in height, muscles, and organs, making the child extremely large for his or her age. other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness. it may begin at any age before epiphyseal fusion. the most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much gh, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including carney complex; mccune-albright syndrome ; multiple endocrine neoplasia type 1 (men-1) and type 4; and neurofibromatosis. in some cases the disease is caused by mutations in the gpr101 gene. treatment typically includes surgery to remove the tumor and can cure many cases. medication or radiation therapy may be used to reduce gh release or block the effect of gh.  if the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly. last updated: 2/10/2017

MalaCards based summary : Gigantism is related to cerebral gigantism jaw cysts and gigantism advanced bone age hoarse cry, and has symptoms including endocrine system signs and symptoms An important gene associated with Gigantism is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways is Growth hormone receptor signaling. The drugs lanreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and breast.

Wikipedia : 71 Gigantism, also known as giantism (from Greek γίγας gigas, \"giant\", plural γίγαντες... more...

Related Diseases for Gigantism

Diseases related to Gigantism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
id Related Disease Score Top Affiliating Genes
1 cerebral gigantism jaw cysts 11.8
2 gigantism advanced bone age hoarse cry 11.8
3 pituitary adenoma, growth hormone-secreting 11.7
4 perlman syndrome 11.7
5 beckwith-wiedemann syndrome 11.6
6 sotos syndrome 1 11.6
7 simpson-golabi-behmel syndrome, type 1 11.4
8 chromosome xq26.3 duplication syndrome 11.4
9 acromegaly 11.4
10 x-linked acrogigantism due to a point mutation 11.1
11 proteus syndrome, somatic 10.9
12 lipodystrophy, congenital generalized, type 2 10.9
13 simpson-golabi-behmel syndrome 10.9
14 mccune-albright syndrome, somatic, mosaic 10.7
15 simpson-golabi-behmel syndrome, type 2 10.7
16 pituitary adenoma, growth hormone-secreting 2 10.7
17 cowden syndrome 1 10.7
18 macrocephaly mesodermal hamartoma spectrum 10.7
19 lipodystrophy, congenital generalized, type 1 10.7
20 cerebritis 10.4
21 microtia, hearing impairment, and cleft palate 10.1 GH1 GHRH
22 african histoplasmosis 10.1 AIP PRL
23 7q11.23 duplication syndrome 10.1 GH1 PRL
24 microvascular complications of diabetes 3 10.1 GH1 GHRH
25 vertebral artery occlusion 10.1 AIP PRL
26 ossification of the posterior longitudinal ligament of spine 10.1 GH1 GHRH
27 bowen-conradi syndrome 10.1 AIP PRL
28 dykes markes harper syndrome 10.1 GH1 GHRH
29 grin2a-related speech disorders and epilepsy 10.1 GH1 PRL
30 cerebral hemisphere lipoma 10.1 GH1 PRL
31 congenital tricuspid stenosis 10.1 GH1 PRL
32 olfactory nerve neoplasm 10.1 GH1 PRL
33 caudal regression syndrome 10.1 GH1 PRL
34 osseous heteroplasia, progressive 10.1 GH1 PRL
35 plasmalogens synthesis deficiency isolated 10.1 GH1 PRL
36 adrenal cortical adenocarcinoma 10.1 GHRH PRL
37 gynandroblastoma 10.1 GH1 GHRH
38 rheumatic encephalitis 10.1 GH1 PRL
39 axial osteomalacia 10.0 GH1 PRL
40 cone-rod dystrophy 5 10.0 AIP GPR101
41 adult i blood group with or without congenital cataract 10.0 GH1 PRL
42 adenoma 10.0
43 mucopolysaccharidosis type vi 10.0 GH1 PRL
44 bile acid synthesis defect, congenital, 4 10.0 GH1 PRL
45 macroglossia 10.0
46 endocrine organ benign neoplasm 10.0 AIP PRL
47 capillary lymphangioma 10.0 GH1 PRL
48 immune system organ benign neoplasm 10.0 AIP GHRH PRL
49 intermittent squint 10.0 GH1 GHRH PRL
50 diencephalic neoplasm 10.0 GH1 GHRH PRL

Graphical network of the top 20 diseases related to Gigantism:



Diseases related to Gigantism

Symptoms & Phenotypes for Gigantism

UMLS symptoms related to Gigantism:


endocrine system signs and symptoms

Drugs & Therapeutics for Gigantism

Drugs for Gigantism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
lanreotide Approved Phase 4 108736-35-2
2
Somatostatin Approved Phase 4 38916-34-6, 51110-01-1 53481605
3 Hormone Antagonists Phase 4
4 Hormones Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
6 Angiopeptin Phase 4
7 Liver Extracts Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Pilot Study of Pre- and Post-operative Use of Somatuline Depot. Completed NCT01861717 Phase 4
2 Efficacy and Safety of Pasireotide LAR in Japanese Patients With Acromegaly or Pituitary Gigantism Completed NCT01673646 Phase 2
3 Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA Recruiting NCT00461188
4 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Recruiting NCT01775332

Search NIH Clinical Center for Gigantism

Genetic Tests for Gigantism

Anatomical Context for Gigantism

MalaCards organs/tissues related to Gigantism:

39
Pituitary, Bone, Breast, Liver, Colon, Hypothalamus, B Cells

Publications for Gigantism

Articles related to Gigantism:

(show top 50) (show all 464)
id Title Authors Year
1
Gigantism and Its Implications for the History of Life. ( 26771527 )
2016
2
Bilateral gigantic earlobe keloids. ( 26833527 )
2016
3
Gigantic vascular anomaly in a PHACE syndrome patient managed with photodynamic therapy. ( 27229363 )
2016
4
Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening. ( 27287035 )
2016
5
Pituitary gigantism: a retrospective case series. ( 26887033 )
2016
6
Corrigendum: Gigantism and comparative life-history parameters of tyrannosaurid dinosaurs. ( 26675726 )
2016
7
Convergent evolution of sperm gigantism and the developmental origins of sperm size variability in Caenorhabditis nematodes. ( 27565121 )
2016
8
Giants among larges: how gigantism impacts giant virus entry into amoebae. ( 27039270 )
2016
9
Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome. ( 26607152 )
2016
10
Genetics of gigantism and acromegaly. ( 27657986 )
2016
11
Multiple origins of gigantism in stem baleen whales. ( 27717969 )
2016
12
Benign or Malignant? Two Case Reports of Gigantic Prostatic Cyst. ( 27500085 )
2016
13
Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland. ( 27650164 )
2016
14
Genetic drift and mutational hazard in the evolution of salamander genomic gigantism. ( 27714793 )
2016
15
A rare case of Acro-gigantism. ( 27728208 )
2016
16
Macrodystrophia Lipomatosa: An Unusual Cause of Localized Gigantism. ( 27293271 )
2016
17
Gigantism: X-linked acrogigantism and GPR101 mutations. ( 27743704 )
2016
18
Gigantic Suprapubic Lymphedema: A Case Study. ( 27574599 )
2016
19
Salamanders' slow slither into genomic gigantism(). ( 27861781 )
2016
20
Localised gigantism. ( 25849020 )
2015
21
Ecological explanations to island gigantism: dietary niche divergence, predation, and size in an endemic lizard. ( 26405734 )
2015
22
Retraction notice to a89Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in micea89 [Eur J Cancer 47 (2011) 470a89478]. ( 25977969 )
2015
23
Pituitary gigantism: Causes and clinical characteristics. ( 26585365 )
2015
24
The Oldest Recorded Case of Acromegaly and Gigantism in Iran. ( 26443258 )
2015
25
Gigantism, acromegaly, and GPR101 mutations. ( 25806921 )
2015
26
Gigantism, acromegaly, and GPR101 mutations. ( 25806920 )
2015
27
Gigantism, acromegaly, and GPR101 mutations. ( 25806919 )
2015
28
Localized gigantism. ( 25987124 )
2015
29
Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients. ( 26187128 )
2015
30
Pituitary gigantism: update on molecular biology and management. ( 26574647 )
2015
31
Gigantism Remains a Clinical Challenge. ( 26621024 )
2015
32
A probable case of gigantism/acromegaly in skeletal remains from the Jewish necropolis of "Ronda Sur" (Lucena, CA^rdoba, Spain; VIII-XII centuries CE). ( 25776010 )
2015
33
Pituitary Gigantism - Experience of a Single Centre from Western India. ( 25716640 )
2015
34
A gigantic anogenital lesion: buschke-lowenstein tumor. ( 25431694 )
2014
35
Avian-style respiration allowed gigantism in pterosaurs. ( 24855669 )
2014
36
Gigantic business: titin properties and function through thick and thin. ( 24625729 )
2014
37
Lower limb gigantism, lymphedema, and painful varicosities following a thigh vascular access graft. ( 24467313 )
2014
38
Starvation reveals the cause of infection-induced castration and gigantism. ( 25143034 )
2014
39
Isolated gigantism of digits. ( 25015571 )
2014
40
A novel germline mutation in the aryl hydrocarbon receptor-interacting protein (Aip) gene in an Italian family with gigantism. ( 24996936 )
2014
41
Proteus syndrome: A rare cause of gigantic limb. ( 24860761 )
2014
42
Gigantism caused by growth hormone secreting pituitary adenoma. ( 25077093 )
2014
43
Rare gigantic giant cell tumor of anterior ribs in a young lady. ( 25767344 )
2014
44
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. ( 25470569 )
2014
45
Hereditary Gigantism-the biblical giant Goliath and his brothers. ( 25075136 )
2014
46
Editorial: Gigantism: a new way to prolong neutrophil life. ( 25271292 )
2014
47
Change in the immunophenotype of a somatotroph adenoma resulting in gigantism. ( 25396071 )
2014
48
Gigantic lymphangioma with marked extraluminal progression of the ascending colon: report of a case. ( 25344823 )
2014
49
A Gray-purple Mass on the Floor of the Mouth: Gigantic Mucogingival Pyogenic Granuloma in a Teenage Patient. ( 24987485 )
2014
50
Pituitary gigantism treated successfully with the growth hormone receptor antagonist, pegvisomant. ( 23441666 )
2013

Variations for Gigantism

Expression for Gigantism

Search GEO for disease gene expression data for Gigantism.

Pathways for Gigantism

Pathways related to Gigantism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.24 GH1 PRL

GO Terms for Gigantism

Cellular components related to Gigantism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Gigantism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to estradiol GO:0032355 9.32 GH1 PRL
2 positive regulation of multicellular organism growth GO:0040018 9.26 GH1 GHRH
3 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 PRL
4 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 PRL
5 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 GH1 GHRH

Molecular functions related to Gigantism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 GH1 PRL
2 prolactin receptor binding GO:0005148 8.62 GH1 PRL

Sources for Gigantism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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