MCID: GGN002
MIFTS: 28

Gigantism malady

Genetic diseases, Rare diseases, Endocrine diseases categories

Aliases & Classifications for Gigantism

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Sources:
45NIH Rare Diseases, 47Novoseek, 65UMLS
See all sources

Aliases & Descriptions for Gigantism:

Name: Gigantism 45 47 65


Classifications:



Summaries for Gigantism

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NIH Rare Diseases:45 Gigantism is abnormally large growth due to an excess of growth hormone (gh) during childhood, before the bone growth plates have closed (epiphyseal fusion). it causes excessive growth in height, muscles, and organs, making the child extremely large for age. other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness. it may begin at any age before epiphyseal fusion. the most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much gh, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including carney complex; mccune-albright syndrome (mas); multiple endocrine neoplasia type 1 (men-1); and neurofibromatosis. treatment typically includes surgery to remove the tumor and can cure many cases. medication or radiation therapy may be used to reduce gh release or block the effect of gh. if the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly. last updated: 12/10/2010

MalaCards based summary: Gigantism is related to hyperprolactinemia and hypothyroidism. An important gene associated with Gigantism is AIP (Aryl Hydrocarbon Receptor Interacting Protein). Affiliated tissues include pituitary, bone and breast, and related mouse phenotype liver/biliary system.

Related Diseases for Gigantism

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Diseases in the Gigantism family:

Familial Infantile Gigantism

Diseases related to Gigantism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1hyperprolactinemia30.3GHRH, PRL
2hypothyroidism30.2GHRH, PRL
3pituitary adenoma, growth hormone-secreting29.3AIP, GHRH, GPR101, PRL
4gigantism advanced bone age hoarse cry29.2AIP, GHRH, GPC3, GPR101, PRL
5cerebritis10.8
6pituitary gigantism10.7
7acromegaly10.7
8adenoma10.5
9perlman syndrome10.4
10macroglossia10.4
11sotos syndrome 110.4
12beckwith-wiedemann syndrome10.4
13neurofibromatosis10.4
14pituitary adenoma10.4
15cerebral gigantism jaw cysts10.3
16fibrous dysplasia10.3
17familial infantile gigantism10.3
18proteus syndrome, somatic10.2
19insulin-like growth factor i10.2
20tuberous sclerosis10.2
21simpson-golabi-behmel syndrome10.2
22hypopituitarism10.2
23lipomatosis10.2
24dwarfism10.2
25renal dysplasia10.2
26hemangioma10.1
27diabetic ketoacidosis10.1
28keratosis10.1
29slipped capital femoral epiphysis10.1
30aneurysm10.1
31pituitary tumors10.1
32systemic lupus erythematosus10.0
33lipodystrophy, congenital generalized, type 210.0
34marfan syndrome10.0
35mccune-albright syndrome, somatic, mosaic10.0
36simpson-golabi-behmel syndrome, type 110.0
37b-cell lymphomas10.0
38burn scar10.0
39burns10.0
40hepatitis10.0
41rhinosporidiosis10.0
42neuronitis10.0
43arthropathy10.0
44hypogonadism10.0
45lupus erythematosus10.0
46neuropathy10.0
47peripheral neuropathy10.0
48diencephalic syndrome10.0
49pyogenic granuloma10.0
50multiple endocrine neoplasia10.0

Graphical network of the top 20 diseases related to Gigantism:



Diseases related to gigantism

Symptoms for Gigantism

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Drugs & Therapeutics for Gigantism

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Drugs for Gigantism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinPhase 414151110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2lanreotidePhase 466
3AngiopeptinPhase 466

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.RecruitingNCT01861717Phase 4
2Efficacy and Safety of Pasireotide LAR in Japanese Patients With Acromegaly or Pituitary GigantismActive, not recruitingNCT01673646Phase 2
3Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPARecruitingNCT00461188
4Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education ToolsRecruitingNCT01775332

Search NIH Clinical Center for Gigantism

Genetic Tests for Gigantism

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Anatomical Context for Gigantism

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MalaCards organs/tissues related to Gigantism:

33
Pituitary, Bone, Breast, Cortex, Hypothalamus, Liver, Colon

Animal Models for Gigantism or affiliated genes

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MGI Mouse Phenotypes related to Gigantism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0AIP, GHRH, PRL

Publications for Gigantism

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Articles related to Gigantism:

(show top 50)    (show all 440)
idTitleAuthorsYear
1
Pituitary gigantism: update on molecular biology and management. (26574647)
2015
2
Starvation reveals the cause of infection-induced castration and gigantism. (25143034)
2014
3
Rare gigantic giant cell tumor of anterior ribs in a young lady. (25767344)
2014
4
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent. (23729615)
2013
5
Peripheral gigant cell granuloma (giant cell epulis) associated with metabolic diseases: case report and literature review. (24353822)
2013
6
Gigantic splenomegaly in a 27-year-old male of South-East Asian descent with concurrent diagnosis of myeloproliferative neoplasm and hemoglobin H disease. (23672282)
2013
7
Why might they be giants? Towards an understanding of polar gigantism. (22623187)
2012
8
Gigantic intrapericardial bronchogenic cyst. (21625867)
2011
9
The evolution of island gigantism and body size variation in tortoises and turtles. (21270022)
2011
10
Acromegaly and gigantism in the medical literature. Case descriptions in the era before and the early years after the initial publication of Pierre Marie (1886). (18683056)
2009
11
Macrodactyly, syndactyly, and localized gigantism of the forefoot. A case report. (16878777)
2005
12
Pegvisomant therapy in pituitary gigantism: successful treatment in a 12-year-old girl. (16061823)
2005
13
Clinical report of congenital lymphatic malformations and partial gigantism of the hands associated with a heterogeneous karyotype. (15472995)
2005
14
Parasite alteration of host shape: a quantitative approach to gigantism helps elucidate evolutionary advantages. (15002898)
2004
15
Gigantism associated with slipped capital femoral epiphysis. (14651152)
2003
16
Platelet gigantism associated with cholestyramine therapy. (11718596)
2001
17
Neurofibromatosis, gigantism, elephantiasis neuromatosa and recurrent massive subperiosteal hematoma: a new case report and review of 7 case reports from the literature. (11383296)
2001
18
Genomic gigantism: DNA loss is slow in mountain grasshoppers. (11158383)
2001
19
A gigantic squamous cell carcinoma with hypercalcemia arising in an old burn scar. (11562052)
2001
20
Gigantism (25905378)
2000
21
Effects of octreotide infusion, surgery and estrogen on suppression of height increase and 20K growth hormone ratio in a girl with gigantism due to a growth hormone-secreting macroadenoma. (11044798)
2000
22
Gigantism. (10599691)
1999
23
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. (10519386)
1999
24
Serial neuroimaging studies in Sotos syndrome (cerebral gigantism syndrome). (9522351)
1998
25
Pyodermia chronica glutealis complicated by acromegalic gigantism. (9609982)
1998
26
Breast gigantism due to D-penicillamine. (8149272)
1994
27
Pathological and experimental investigations in a case of gigantism. (8382895)
1993
28
Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. (8421089)
1993
29
Expression of metallothionein-human growth hormone fusion genes in transgenic mice results in disproportionate skeletal gigantism. (1938045)
1991
30
Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene. (1848356)
1991
31
McCune-Albright syndrome with gigantism and hyperprolactinemia. (3680873)
1987
32
Perlman syndrome: familial renal dysplasia with Wilms tumor, fetal gigantism, and multiple congenital anomalies. (3024486)
1986
33
Gigantism associated with McCune-Albright's syndrome. (3934058)
1985
34
Tubular gigantism of the kidney in a 41-mm, Streeter's 23rd horizon, human fetus with a comparative study of renal structures in normal human fetuses at a similar stage of development. (6519136)
1984
35
A new X-linked dysplasia gigantism syndrome: identical with the Simpson dysplasia syndrome? (6490008)
1984
36
Cognition in cerebral gigantism: are the estimates of mental retardation too high? (6662920)
1983
37
Pituitary gigantism: a disabling condition. (7165969)
1982
38
The parasitic castration and gigantism of Lymnaea truncatula infected with the larval stages of Fasciola hepatica. (6892863)
1980
39
Unilateral delayed opercularization in a case of Sotos' syndrome (Cerebral Gigantism). (7422120)
1980
40
Cerebral gigantism. (1227563)
1975
41
Localised gigantism of the extremities. (4270789)
1973
42
Exomphalos-macroglossia-gigantism (visceromegaly) syndrome. (The Beckwith-Wiedemann syndrome). (5058514)
1972
43
Exomphalos-macroglossia-gigantism syndrome in Jamaican infants. (5434588)
1970
44
Atypical cerebral gigantism. A case report. (5763313)
1969
45
Cerebral gigantism in childhood. Report of two cases. (5678413)
1968
46
Cerebral gigantism in childhood. A report of two cases and a review of the literature. (5298529)
1967
47
An unusual form of gigantism. A case report. (5981706)
1966
48
Thyrotoxicosis and gigantism associated with "Klinefelter's syndrome". (5850468)
1965
49
Congenital gigantism of peroxidase granules; the first case ever reported of qualitative abnormity of peroxidase. (13169161)
1954
50
Gigantism produced in normal female rats by chronic treatment with pure pituitary growth hormone; skeletal changes; tibia, costochondral junction, and caudal vertebrae. (18897304)
1947

Variations for Gigantism

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Expression for genes affiliated with Gigantism

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Search GEO for disease gene expression data for Gigantism.

Pathways for genes affiliated with Gigantism

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GO Terms for genes affiliated with Gigantism

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Molecular functions related to Gigantism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.4GHRH, PRL

Sources for Gigantism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet