Aliases & Classifications for Gigantism

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Aliases & Descriptions for Gigantism:

Name: Gigantism 48 50 68

Classifications:



Summaries for Gigantism

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NIH Rare Diseases:48 Gigantism is abnormally large growth due to an excess of growth hormone (GH) during childhood, before the bone growth plates have closed (epiphyseal fusion). It causes excessive growth in height, muscles, and organs, making the child extremely large for age. Other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness. It may begin at any age before epiphyseal fusion. The most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much GH, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including Carney complex; McCune-Albright syndrome (MAS); Multiple endocrine neoplasia type 1 (MEN-1); and Neurofibromatosis. Treatment typically includes surgery to remove the tumor and can cure many cases. Medication or radiation therapy may be used to reduce GH release or block the effect of GH. If the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly. Last updated: 12/10/2010

MalaCards based summary: Gigantism is related to cerebral gigantism jaw cysts and gigantism advanced bone age hoarse cry, and has symptoms including endocrine system signs and symptoms An important gene associated with Gigantism is AIP (Aryl Hydrocarbon Receptor Interacting Protein). Affiliated tissues include pituitary, liver and bone.

Wikipedia:71 Gigantism, also known as giantism (from Greek γίγας gigas, \"giant\", plural γίγαντες... more...

Related Diseases for Gigantism

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Diseases related to Gigantism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral gigantism jaw cysts11.8
2gigantism advanced bone age hoarse cry11.8
3pituitary adenoma, growth hormone-secreting11.7
4perlman syndrome11.7
5beckwith-wiedemann syndrome11.7
6sotos syndrome 111.6
7simpson-golabi-behmel syndrome, type 111.5
8chromosome xq26.3 duplication syndrome11.4
9x-linked acrogigantism due to a point mutation11.1
10proteus syndrome, somatic10.9
11cowden syndrome 110.9
12lipodystrophy, congenital generalized, type 210.9
13mccune-albright syndrome, somatic, mosaic10.7
14simpson-golabi-behmel syndrome, type 210.7
15pituitary adenoma, growth hormone-secreting 210.7
16lipodystrophy, congenital generalized, type 110.7
17macrocephaly mesodermal hamartoma spectrum10.7
18acromegaly10.7
19cerebritis10.4
20adenoma10.0
21macroglossia10.0
22pituitary adenoma9.9
23bardet-biedl syndrome9.9GHRH, PRL
24fibrous dysplasia9.8
25mobitz type ii atrioventricular block9.8AIP, PRL
26hyperprolactinemia9.8
27retinal microaneurysm9.8AIP, PRL
28fallopian tube clear cell adenocarcinoma9.8GHRH, PRL
29ehlers-danlos syndrome, type viii9.8AIP, PRL
30osseous heteroplasia, progressive9.8AIP, PRL
31craniopharyngioma9.8GHRH, PRL
32cold-induced sweating syndrome 29.8AIP, PRL
33adrenal carcinoma9.8GHRH, PRL
34lipoadenoma9.8AIP, PRL
35lymphoma9.8
36lipomatosis9.8
37hypopituitarism9.8
38dwarfism9.8
39renal dysplasia9.8
40diabetes insipidus9.7GHRH, PRL
41insulin-like growth factor i9.7
42hemangioma9.7
43hypothyroidism9.7
44keratosis9.7
45slipped capital femoral epiphysis9.7
46aneurysm9.7
47vestibular gland benign neoplasm9.6AIP, PRL
48glaucoma iridogoniodysgenesia9.6AIP, GHRH, GPR101
49prolactin producing pituitary tumor9.6AIP, PRL
50systemic lupus erythematosus9.6

Graphical network of the top 20 diseases related to Gigantism:



Diseases related to gigantism

Symptoms & Phenotypes for Gigantism

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UMLS symptoms related to Gigantism:


endocrine system signs and symptoms

Drugs & Therapeutics for Gigantism

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Drugs for Gigantism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
lanreotideapprovedPhase 482108736-35-2
Synonyms:
Lanreotide
 
Lanreotide acetate
Somatuline Depot
2
SomatostatinapprovedPhase 422938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
3Liver ExtractsPhase 43868
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
5Hormone AntagonistsPhase 412778
6HormonesPhase 413979
7AngiopeptinPhase 482

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.CompletedNCT01861717Phase 4
2Efficacy and Safety of Pasireotide LAR in Japanese Patients With Acromegaly or Pituitary GigantismActive, not recruitingNCT01673646Phase 2
3Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPARecruitingNCT00461188
4Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education ToolsRecruitingNCT01775332

Search NIH Clinical Center for Gigantism

Genetic Tests for Gigantism

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Anatomical Context for Gigantism

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MalaCards organs/tissues related to Gigantism:

36
Pituitary, Liver, Bone, Hypothalamus, Breast, Colon, B cells

Publications for Gigantism

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Articles related to Gigantism:

(show top 50)    (show all 464)
idTitleAuthorsYear
1
Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome. (26607152)
2016
2
Giants among larges: how gigantism impacts giant virus entry into amoebae. (27039270)
2016
3
Benign or Malignant? Two Case Reports of Gigantic Prostatic Cyst. (27500085)
2016
4
Gigantism and Its Implications for the History of Life. (26771527)
2016
5
Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening. (27287035)
2016
6
Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland. (27650164)
2016
7
Salamanders' slow slither into genomic gigantism(). (27861781)
2016
8
Gigantic vascular anomaly in a PHACE syndrome patient managed with photodynamic therapy. (27229363)
2016
9
Bilateral gigantic earlobe keloids. (26833527)
2016
10
Macrodystrophia Lipomatosa: An Unusual Cause of Localized Gigantism. (27293271)
2016
11
Gigantism: X-linked acrogigantism and GPR101 mutations. (27743704)
2016
12
A rare case of Acro-gigantism. (27728208)
2016
13
Pituitary gigantism: a retrospective case series. (26887033)
2016
14
Multiple origins of gigantism in stem baleen whales. (27717969)
2016
15
Convergent evolution of sperm gigantism and the developmental origins of sperm size variability in Caenorhabditis nematodes. (27565121)
2016
16
Corrigendum: Gigantism and comparative life-history parameters of tyrannosaurid dinosaurs. (26675726)
2016
17
Gigantic Suprapubic Lymphedema: A Case Study. (27574599)
2016
18
Genetics of gigantism and acromegaly. (27657986)
2016
19
Genetic drift and mutational hazard in the evolution of salamander genomic gigantism. (27714793)
2016
20
Pituitary gigantism: update on molecular biology and management. (26574647)
2015
21
Ecological explanations to island gigantism: dietary niche divergence, predation, and size in an endemic lizard. (26405734)
2015
22
Localised gigantism. (25849020)
2015
23
Gigantism, acromegaly, and GPR101 mutations. (25806920)
2015
24
Retraction notice to a89Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in micea89 [Eur J Cancer 47 (2011) 470a89478]. (25977969)
2015
25
Gigantism, acromegaly, and GPR101 mutations. (25806921)
2015
26
Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients. (26187128)
2015
27
Pituitary gigantism: Causes and clinical characteristics. (26585365)
2015
28
Gigantism, acromegaly, and GPR101 mutations. (25806919)
2015
29
Pituitary Gigantism - Experience of a Single Centre from Western India. (25716640)
2015
30
Localized gigantism. (25987124)
2015
31
Gigantism Remains a Clinical Challenge. (26621024)
2015
32
The Oldest Recorded Case of Acromegaly and Gigantism in Iran. (26443258)
2015
33
A probable case of gigantism/acromegaly in skeletal remains from the Jewish necropolis of "Ronda Sur" (Lucena, CA^rdoba, Spain; VIII-XII centuries CE). (25776010)
2015
34
Rare gigantic giant cell tumor of anterior ribs in a young lady. (25767344)
2014
35
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. (25470569)
2014
36
Gigantism caused by growth hormone secreting pituitary adenoma. (25077093)
2014
37
Gigantic lymphangioma with marked extraluminal progression of the ascending colon: report of a case. (25344823)
2014
38
A Gray-purple Mass on the Floor of the Mouth: Gigantic Mucogingival Pyogenic Granuloma in a Teenage Patient. (24987485)
2014
39
Gigantic business: titin properties and function through thick and thin. (24625729)
2014
40
Lower limb gigantism, lymphedema, and painful varicosities following a thigh vascular access graft. (24467313)
2014
41
Editorial: Gigantism: a new way to prolong neutrophil life. (25271292)
2014
42
Change in the immunophenotype of a somatotroph adenoma resulting in gigantism. (25396071)
2014
43
Avian-style respiration allowed gigantism in pterosaurs. (24855669)
2014
44
Starvation reveals the cause of infection-induced castration and gigantism. (25143034)
2014
45
A gigantic anogenital lesion: buschke-lowenstein tumor. (25431694)
2014
46
Proteus syndrome: A rare cause of gigantic limb. (24860761)
2014
47
A novel germline mutation in the aryl hydrocarbon receptor-interacting protein (Aip) gene in an Italian family with gigantism. (24996936)
2014
48
Isolated gigantism of digits. (25015571)
2014
49
Hereditary Gigantism-the biblical giant Goliath and his brothers. (25075136)
2014
50
Herbivory and body size: allometries of diet quality and gastrointestinal physiology, and implications for herbivore ecology and dinosaur gigantism. (24204552)
2013

Variations for Gigantism

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Expression for genes affiliated with Gigantism

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Search GEO for disease gene expression data for Gigantism.

Pathways for genes affiliated with Gigantism

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GO Terms for genes affiliated with Gigantism

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Sources for Gigantism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet