Aliases & Classifications for Gigantism

About this section

Aliases & Descriptions for Gigantism:

Name: Gigantism 48 50 68

Classifications:



Summaries for Gigantism

About this section
NIH Rare Diseases:48 Gigantism is abnormally large growth due to an excess of growth hormone (gh) during childhood, before the bone growth plates have closed (epiphyseal fusion). it causes excessive growth in height, muscles, and organs, making the child extremely large for his or her age. other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness. it may begin at any age before epiphyseal fusion. the most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much gh, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including carney complex; mccune-albright syndrome ; multiple endocrine neoplasia type 1 (men-1) and type 4; and neurofibromatosis. in some cases the disease is caused by mutations in the gpr101 gene. treatment typically includes surgery to remove the tumor and can cure many cases. medication or radiation therapy may be used to reduce gh release or block the effect of gh.  if the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly. last updated: 2/10/2017

MalaCards based summary: Gigantism is related to cerebral gigantism jaw cysts and gigantism advanced bone age hoarse cry, and has symptoms including endocrine system signs and symptoms An important gene associated with Gigantism is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways is Growth hormone receptor signaling. Affiliated tissues include pituitary, bone and breast.

Wikipedia:71 Gigantism, also known as giantism (from Greek γίγας gigas, \"giant\", plural... more...

Related Diseases for Gigantism

About this section

Diseases related to Gigantism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral gigantism jaw cysts11.8
2gigantism advanced bone age hoarse cry11.8
3pituitary adenoma, growth hormone-secreting11.7
4perlman syndrome11.7
5beckwith-wiedemann syndrome11.6
6sotos syndrome 111.6
7simpson-golabi-behmel syndrome, type 111.4
8chromosome xq26.3 duplication syndrome11.4
9acromegaly11.4
10x-linked acrogigantism due to a point mutation11.1
11lipodystrophy, congenital generalized, type 210.9
12proteus syndrome, somatic10.9
13simpson-golabi-behmel syndrome10.9
14cowden syndrome 110.7
15mccune-albright syndrome, somatic, mosaic10.7
16simpson-golabi-behmel syndrome, type 210.7
17pituitary adenoma, growth hormone-secreting 210.7
18lipodystrophy, congenital generalized, type 110.7
19macrocephaly mesodermal hamartoma spectrum10.7
20cerebritis10.4
21microtia, hearing impairment, and cleft palate10.1GH1, GHRH
22african histoplasmosis10.1AIP, PRL
237q11.23 duplication syndrome10.1GH1, PRL
24microvascular complications of diabetes 310.1GH1, GHRH
25vertebral artery occlusion10.1AIP, PRL
26ossification of the posterior longitudinal ligament of spine10.1GH1, GHRH
27bowen-conradi syndrome10.1AIP, PRL
28dykes markes harper syndrome10.1GH1, GHRH
29grin2a-related speech disorders and epilepsy10.1GH1, PRL
30cerebral hemisphere lipoma10.1GH1, PRL
31congenital tricuspid stenosis10.1GH1, PRL
32olfactory nerve neoplasm10.1GH1, PRL
33caudal regression syndrome10.1GH1, PRL
34osseous heteroplasia, progressive10.1GH1, PRL
35plasmalogens synthesis deficiency isolated10.1GH1, PRL
36adrenal cortical adenocarcinoma10.1GHRH, PRL
37gynandroblastoma10.1GH1, GHRH
38rheumatic encephalitis10.1GH1, PRL
39axial osteomalacia10.0GH1, PRL
40cone-rod dystrophy 510.0AIP, GPR101
41adult i blood group with or without congenital cataract10.0GH1, PRL
42adenoma10.0
43mucopolysaccharidosis type vi10.0GH1, PRL
44bile acid synthesis defect, congenital, 410.0GH1, PRL
45macroglossia10.0
46endocrine organ benign neoplasm10.0AIP, PRL
47capillary lymphangioma10.0GH1, PRL
48immune system organ benign neoplasm10.0AIP, GHRH, PRL
49intermittent squint10.0GH1, GHRH, PRL
50diencephalic neoplasm10.0GH1, GHRH, PRL

Graphical network of the top 20 diseases related to Gigantism:



Diseases related to gigantism

Symptoms & Phenotypes for Gigantism

About this section

UMLS symptoms related to Gigantism:


endocrine system signs and symptoms

Drugs & Therapeutics for Gigantism

About this section

Drugs for Gigantism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
lanreotideapprovedPhase 486108736-35-2
Synonyms:
Lanreotide
 
Lanreotide acetate
Somatuline Depot
2
SomatostatinapprovedPhase 423738916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
3Liver ExtractsPhase 44067
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 413168
5Hormone AntagonistsPhase 413180
6HormonesPhase 414415
7AngiopeptinPhase 486

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.CompletedNCT01861717Phase 4
2Efficacy and Safety of Pasireotide LAR in Japanese Patients With Acromegaly or Pituitary GigantismCompletedNCT01673646Phase 2
3Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPARecruitingNCT00461188
4Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education ToolsRecruitingNCT01775332

Search NIH Clinical Center for Gigantism

Genetic Tests for Gigantism

About this section

Anatomical Context for Gigantism

About this section

MalaCards organs/tissues related to Gigantism:

36
Pituitary, Bone, Breast, Liver, Hypothalamus, Colon, B cells

Publications for Gigantism

About this section

Articles related to Gigantism:

(show top 50)    (show all 464)
idTitleAuthorsYear
1
Gigantism and Its Implications for the History of Life. (26771527)
2016
2
Bilateral gigantic earlobe keloids. (26833527)
2016
3
Gigantic vascular anomaly in a PHACE syndrome patient managed with photodynamic therapy. (27229363)
2016
4
Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening. (27287035)
2016
5
Pituitary gigantism: a retrospective case series. (26887033)
2016
6
Corrigendum: Gigantism and comparative life-history parameters of tyrannosaurid dinosaurs. (26675726)
2016
7
Convergent evolution of sperm gigantism and the developmental origins of sperm size variability in Caenorhabditis nematodes. (27565121)
2016
8
Giants among larges: how gigantism impacts giant virus entry into amoebae. (27039270)
2016
9
Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome. (26607152)
2016
10
Genetics of gigantism and acromegaly. (27657986)
2016
11
Multiple origins of gigantism in stem baleen whales. (27717969)
2016
12
Benign or Malignant? Two Case Reports of Gigantic Prostatic Cyst. (27500085)
2016
13
Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland. (27650164)
2016
14
Genetic drift and mutational hazard in the evolution of salamander genomic gigantism. (27714793)
2016
15
A rare case of Acro-gigantism. (27728208)
2016
16
Macrodystrophia Lipomatosa: An Unusual Cause of Localized Gigantism. (27293271)
2016
17
Gigantism: X-linked acrogigantism and GPR101 mutations. (27743704)
2016
18
Gigantic Suprapubic Lymphedema: A Case Study. (27574599)
2016
19
Salamanders' slow slither into genomic gigantism(). (27861781)
2016
20
Localised gigantism. (25849020)
2015
21
Ecological explanations to island gigantism: dietary niche divergence, predation, and size in an endemic lizard. (26405734)
2015
22
Retraction notice to a89Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in micea89 [Eur J Cancer 47 (2011) 470a89478]. (25977969)
2015
23
Pituitary gigantism: Causes and clinical characteristics. (26585365)
2015
24
The Oldest Recorded Case of Acromegaly and Gigantism in Iran. (26443258)
2015
25
Gigantism, acromegaly, and GPR101 mutations. (25806921)
2015
26
Gigantism, acromegaly, and GPR101 mutations. (25806920)
2015
27
Gigantism, acromegaly, and GPR101 mutations. (25806919)
2015
28
Localized gigantism. (25987124)
2015
29
Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients. (26187128)
2015
30
Pituitary gigantism: update on molecular biology and management. (26574647)
2015
31
Gigantism Remains a Clinical Challenge. (26621024)
2015
32
A probable case of gigantism/acromegaly in skeletal remains from the Jewish necropolis of "Ronda Sur" (Lucena, CA^rdoba, Spain; VIII-XII centuries CE). (25776010)
2015
33
Pituitary Gigantism - Experience of a Single Centre from Western India. (25716640)
2015
34
A gigantic anogenital lesion: buschke-lowenstein tumor. (25431694)
2014
35
Avian-style respiration allowed gigantism in pterosaurs. (24855669)
2014
36
Gigantic business: titin properties and function through thick and thin. (24625729)
2014
37
Lower limb gigantism, lymphedema, and painful varicosities following a thigh vascular access graft. (24467313)
2014
38
Starvation reveals the cause of infection-induced castration and gigantism. (25143034)
2014
39
Isolated gigantism of digits. (25015571)
2014
40
A novel germline mutation in the aryl hydrocarbon receptor-interacting protein (Aip) gene in an Italian family with gigantism. (24996936)
2014
41
Proteus syndrome: A rare cause of gigantic limb. (24860761)
2014
42
Gigantism caused by growth hormone secreting pituitary adenoma. (25077093)
2014
43
Rare gigantic giant cell tumor of anterior ribs in a young lady. (25767344)
2014
44
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. (25470569)
2014
45
Hereditary Gigantism-the biblical giant Goliath and his brothers. (25075136)
2014
46
Editorial: Gigantism: a new way to prolong neutrophil life. (25271292)
2014
47
Change in the immunophenotype of a somatotroph adenoma resulting in gigantism. (25396071)
2014
48
Gigantic lymphangioma with marked extraluminal progression of the ascending colon: report of a case. (25344823)
2014
49
A Gray-purple Mass on the Floor of the Mouth: Gigantic Mucogingival Pyogenic Granuloma in a Teenage Patient. (24987485)
2014
50
Pituitary gigantism treated successfully with the growth hormone receptor antagonist, pegvisomant. (23441666)
2013

Variations for Gigantism

About this section

Expression for genes affiliated with Gigantism

About this section
Search GEO for disease gene expression data for Gigantism.

Pathways for genes affiliated with Gigantism

About this section

Pathways related to Gigantism according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4GH1, PRL

GO Terms for genes affiliated with Gigantism

About this section

Cellular components related to Gigantism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:00319049.4GH1, PRL

Biological processes related to Gigantism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:004356810.1GH1, GHRH
2positive regulation of multicellular organism growthGO:004001810.0GH1, GHRH
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:006039710.0GH1, PRL
4positive regulation of JAK-STAT cascadeGO:004642710.0GH1, PRL
5response to estradiolGO:00323559.4GH1, PRL

Molecular functions related to Gigantism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00051489.4GH1, PRL
2hormone activityGO:00051799.3GH1, PRL

Sources for Gigantism

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet