Aliases & Classifications for Gigantism

MalaCards integrated aliases for Gigantism:

Name: Gigantism 50 52 69

Classifications:



Summaries for Gigantism

NIH Rare Diseases : 50 gigantism is abnormally large growth due to an excess of growth hormone (gh) during childhood, before the bone growth plates have closed (epiphyseal fusion). it causes excessive growth in height, muscles, and organs, making the child extremely large for his or her age. other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness. it may begin at any age before epiphyseal fusion. the most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much gh, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including carney complex; mccune-albright syndrome ; multiple endocrine neoplasia type 1 (men-1) and type 4; and neurofibromatosis. in some cases the disease is caused by mutations in the gpr101 gene. treatment typically includes surgery to remove the tumor and can cure many cases. medication or radiation therapy may be used to reduce gh release or block the effect of gh.  if the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly. last updated: 2/10/2017

MalaCards based summary : Gigantism is related to cerebral gigantism jaw cysts and gigantism advanced bone age hoarse cry, and has symptoms including endocrine system signs and symptoms An important gene associated with Gigantism is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways is Growth hormone receptor signaling. The drugs lanreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and breast.

Wikipedia : 72 Gigantism, also known as giantism (from Greek γίγας gigas, \"giant\", plural γίγαντες gigantes), is a... more...

Related Diseases for Gigantism

Diseases related to Gigantism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
id Related Disease Score Top Affiliating Genes
1 cerebral gigantism jaw cysts 12.1
2 gigantism advanced bone age hoarse cry 11.8
3 perlman syndrome 11.7
4 pituitary adenoma, growth hormone-secreting 11.7
5 beckwith-wiedemann syndrome 11.6
6 sotos syndrome 1 11.6
7 simpson-golabi-behmel syndrome, type 1 11.4
8 chromosome xq26.3 duplication syndrome 11.4
9 acromegaly 11.4
10 x-linked acrogigantism due to a point mutation 11.1
11 lipodystrophy, congenital generalized, type 2 10.9
12 proteus syndrome, somatic 10.9
13 simpson-golabi-behmel syndrome 10.9
14 cowden syndrome 1 10.7
15 mccune-albright syndrome, somatic, mosaic 10.7
16 simpson-golabi-behmel syndrome, type 2 10.7
17 pituitary adenoma, growth hormone-secreting 2 10.7
18 lipodystrophy, congenital generalized, type 1 10.7
19 macrocephaly mesodermal hamartoma spectrum 10.7
20 cerebritis 10.4
21 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 10.2 GH1 GHRH
22 ataxia-oculomotor apraxia 3 10.2 AIP GPR101
23 kowarski syndrome 10.2 GH1 GHRH
24 dwarfism familial with muscle spasms 10.1 GH1 GHRH
25 primary hypomagnesemia 10.1 GH1 GHRH
26 adenoma 10.0
27 macroglossia 10.0
28 vertebral artery occlusion 10.0 AIP PRL
29 sifrim-hitz-weiss syndrome 10.0 AIP PRL
30 olfactory nerve neoplasm 9.9 GHRH PRL
31 grubben de cock borghgraef syndrome 9.9 GH1 GHRH
32 osteoclast-like giant cell neoplasm of the pancreas 9.9 GHRH PRL
33 pituitary adenoma 9.9
34 g6pc3 deficiency 9.9 GH1 PRL
35 combined t cell and b cell immunodeficiency 9.9 GH1 PRL
36 aortic valve atresia 9.9 GH1 PRL
37 lactic acidosis 9.9 GH1 PRL
38 acute myocarditis 9.8 GHRH PRL
39 fibrous dysplasia 9.8
40 hypothyroidism, congenital, nongoitrous 4 9.8 GH1 PRL
41 pityriasis rotunda 9.8 GH1 PRL
42 osseous heteroplasia, progressive 9.8 GH1 PRL
43 47,xyy syndrome 9.8 GH1 PRL
44 hyperprolactinemia 9.8
45 lymphoma 9.8
46 tuberous sclerosis 9.8
47 lipomatosis 9.8
48 hypopituitarism 9.8
49 dwarfism 9.8
50 renal dysplasia 9.8

Graphical network of the top 20 diseases related to Gigantism:



Diseases related to Gigantism

Symptoms & Phenotypes for Gigantism

UMLS symptoms related to Gigantism:


endocrine system signs and symptoms

Drugs & Therapeutics for Gigantism

Drugs for Gigantism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 lanreotide Approved Phase 4 108736-35-2
2
Somatostatin Approved Phase 4 38916-34-6, 51110-01-1 53481605
3 Angiopeptin Phase 4
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
7 Liver Extracts Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Pilot Study of Pre- and Post-operative Use of Somatuline Depot. Terminated NCT01861717 Phase 4 lanreotide
2 Efficacy and Safety of Pasireotide LAR in Japanese Patients With Acromegaly or Pituitary Gigantism Completed NCT01673646 Phase 2 SOM230LAR
3 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332
4 Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA Recruiting NCT00461188

Search NIH Clinical Center for Gigantism

Genetic Tests for Gigantism

Anatomical Context for Gigantism

MalaCards organs/tissues related to Gigantism:

39
Pituitary, Bone, Breast, Liver, Hypothalamus, Colon, B Cells

Publications for Gigantism

Articles related to Gigantism:

(show top 50) (show all 474)
id Title Authors Year
1
Regional endothermy as a trigger for gigantism in some extinct macropredatory sharks. ( 28938002 )
2017
2
AIP mutations and gigantism. ( 28483363 )
2017
3
Independent evolution of baleen whale gigantism linked to Plio-Pleistocene ocean dynamics. ( 28539520 )
2017
4
Oldest case of gigantism? Assessment of the alleged remains of Sa-Nakht, king of ancient Egypt. ( 28732663 )
2017
5
Tyrannosauroid integument reveals conflicting patterns of gigantism and feather evolution. ( 28592520 )
2017
6
In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism. ( 28634279 )
2017
7
Submucosal tunneling endoscopic resection of a gigantic esophageal leiomyoma. ( 28946172 )
2017
8
Multiple organ gigantism caused by mutation in VmPPD gene in blackgram (Vigna mungo). ( 28588392 )
2017
9
Earth's oldest 'Bobbit worm' - gigantism in a Devonian eunicidan polychaete. ( 28220886 )
2017
10
Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study. ( 28592706 )
2017
11
Gigantic vascular anomaly in a PHACE syndrome patient managed with photodynamic therapy. ( 27229363 )
2016
12
Corrigendum: Gigantism and comparative life-history parameters of tyrannosaurid dinosaurs. ( 26675726 )
2016
13
Convergent evolution of sperm gigantism and the developmental origins of sperm size variability in Caenorhabditis nematodes. ( 27565121 )
2016
14
Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening. ( 27287035 )
2016
15
A rare case of Acro-gigantism. ( 27728208 )
2016
16
Pituitary gigantism: a retrospective case series. ( 26887033 )
2016
17
Benign or Malignant? Two Case Reports of Gigantic Prostatic Cyst. ( 27500085 )
2016
18
Macrodystrophia Lipomatosa: An Unusual Cause of Localized Gigantism. ( 27293271 )
2016
19
Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome. ( 26607152 )
2016
20
Giants among larges: how gigantism impacts giant virus entry into amoebae. ( 27039270 )
2016
21
Gigantic Suprapubic Lymphedema: A Case Study. ( 27574599 )
2016
22
Genetic drift and mutational hazard in the evolution of salamander genomic gigantism. ( 27714793 )
2016
23
Genetics of gigantism and acromegaly. ( 27657986 )
2016
24
Multiple origins of gigantism in stem baleen whales. ( 27717969 )
2016
25
Gigantism and Its Implications for the History of Life. ( 26771527 )
2016
26
Salamanders' slow slither into genomic gigantism(). ( 27861781 )
2016
27
Bilateral gigantic earlobe keloids. ( 26833527 )
2016
28
Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland. ( 27650164 )
2016
29
Gigantism: X-linked acrogigantism and GPR101 mutations. ( 27743704 )
2016
30
Ecological explanations to island gigantism: dietary niche divergence, predation, and size in an endemic lizard. ( 26405734 )
2015
31
Pituitary Gigantism - Experience of a Single Centre from Western India. ( 25716640 )
2015
32
Localised gigantism. ( 25849020 )
2015
33
Pituitary gigantism: Causes and clinical characteristics. ( 26585365 )
2015
34
Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients. ( 26187128 )
2015
35
A probable case of gigantism/acromegaly in skeletal remains from the Jewish necropolis of "Ronda Sur" (Lucena, CA^rdoba, Spain; VIII-XII centuries CE). ( 25776010 )
2015
36
Gigantism, acromegaly, and GPR101 mutations. ( 25806920 )
2015
37
Gigantism Remains a Clinical Challenge. ( 26621024 )
2015
38
Gigantism, acromegaly, and GPR101 mutations. ( 25806919 )
2015
39
Retraction notice to a89Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in micea89 [Eur J Cancer 47 (2011) 470a89478]. ( 25977969 )
2015
40
Localized gigantism. ( 25987124 )
2015
41
Gigantism, acromegaly, and GPR101 mutations. ( 25806921 )
2015
42
Pituitary gigantism: update on molecular biology and management. ( 26574647 )
2015
43
The Oldest Recorded Case of Acromegaly and Gigantism in Iran. ( 26443258 )
2015
44
Lower limb gigantism, lymphedema, and painful varicosities following a thigh vascular access graft. ( 24467313 )
2014
45
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. ( 25470569 )
2014
46
A gigantic anogenital lesion: buschke-lowenstein tumor. ( 25431694 )
2014
47
Change in the immunophenotype of a somatotroph adenoma resulting in gigantism. ( 25396071 )
2014
48
Isolated gigantism of digits. ( 25015571 )
2014
49
A Gray-purple Mass on the Floor of the Mouth: Gigantic Mucogingival Pyogenic Granuloma in a Teenage Patient. ( 24987485 )
2014
50
Avian-style respiration allowed gigantism in pterosaurs. ( 24855669 )
2014

Variations for Gigantism

Expression for Gigantism

Search GEO for disease gene expression data for Gigantism.

Pathways for Gigantism

Pathways related to Gigantism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.24 GH1 PRL

GO Terms for Gigantism

Cellular components related to Gigantism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Gigantism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of multicellular organism growth GO:0040018 9.26 GH1 GHRH
2 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 PRL
3 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 PRL
4 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 GH1 GHRH

Molecular functions related to Gigantism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 GH1 PRL
2 prolactin receptor binding GO:0005148 8.62 GH1 PRL

Sources for Gigantism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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