MCID: GLB001
MIFTS: 62

Gilbert Syndrome malady

Metabolic diseases, Liver diseases, Genetic diseases categories

Summaries for Gilbert Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Gilbert syndrome is a relatively mild condition characterized by periods of elevated levels of a toxic substance called bilirubin in the blood (hyperbilirubinemia). Bilirubin, which has an orange-yellow tint, is produced when red blood cells are broken down. This substance is removed from the body only after it undergoes a chemical reaction in the liver, which converts the toxic form of bilirubin (unconjugated bilirubin) to a nontoxic form called conjugated bilirubin. People with Gilbert syndrome have a buildup of unconjugated bilirubin in their blood (unconjugated hyperbilirubinemia). In affected individuals, bilirubin levels fluctuate and very rarely increase to levels that cause jaundice, which is yellowing of the skin and whites of the eyes.

MalaCards: Gilbert Syndrome, also known as gilbert's syndrome, is related to kernicterus and hereditary spherocytosis. An important gene associated with Gilbert Syndrome is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Caffeine Pathway, Pharmacokinetics. The compounds Ezogabine and sn38 glucuronide have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and skin.

Disease Ontology:8 A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity.

NIH Rare Diseases:42 Gilbert syndrome is a common, mild liver disorder in which the liver doesn't properly process bilirubin, a substance produced by the breakdown of red blood cells. gilbert syndrome typically doesn't require treatment or pose serious complications. in fact, gilbert syndrome is usually not considered a disease because of its benign nature. many individuals find out they have the disorder by accident, when they have a blood test that shows elevated bilirubin levels. more males than females have been diagnosed with gilbert syndrome. this condition is caused by mutations in the ugt1a1 gene and is inherited in an autosomal recessive pattern. last updated: 5/2/2011

Wikipedia:63 Gilbert\'s syndrome (/ʒiːlˈbɛər/ zheel-BAIR), often shortened to GS, also called... more...

Description from OMIM:46 143500

Aliases & Classifications for Gilbert Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 46OMIM, 20GeneTests, 22GTR, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases, Genetic diseases
Anatomical: Liver diseases


Aliases & Descriptions:

gilbert syndrome 8 42 21 10 46
gilbert's syndrome 8 20 22 21
gilbert's disease 8 42 21
gilbert disease 21 60
constitutional hyperbilirubinemia 8
unconjugated benign bilirubinemia 21
constitutional liver dysfunction 21
hereditary nonhemolytic jaundice 8
familial nonhemolytic jaundice 21
hyperbilirubinemia arias type 42
gilbert-meulengracht syndrome 8
gilbert-lereboullet syndrome 21
hyperbilirubinemia type 1 42
meulengracht syndrome 21
hyperbilirubinemia 1 21
cholemia, familial 42
gilberts syndrome 44


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Disease Ontology8 DOID:2739
OMIM46 143500
NCIt39 C84729
MeSH34 D005878
ICD1025 E80.4

Related Diseases for Gilbert Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Gilbert Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1kernicterus30.7UGT1A1, UGT1A7, UGT1A6, UGT1A4, UGT1A9, G6PD
2hereditary spherocytosis30.4G6PD, UGT1A1
3cholelithiasis30.2UGT1A1, UGT2B4, UGT1A6
4neonatal jaundice30.2G6PD, UGT1A1
5hepatitis30.0UGT1A1, NAT2
6crigler-najjar syndrome30.0UGT1A1, UGT1A4
7deficiency anemia30.0TPMT, G6PD
8beta thalassemia29.9G6PD, UGT1A1
9breast cancer29.9DPYD, UGT1A9, UGT1A, G6PD, UGT1A1, NAT2
10hypertrophic pyloric stenosis10.2
11pyloric stenosis10.2
12paraplegia - intellectual deficit - hyperkeratosis10.1
13cystic fibrosis10.0
14factor vii deficiency10.0
15hemochromatosis10.0
16choledocholithiasis10.0
17hepatitis b10.0
18ulcerative colitis10.0
19adult syndrome10.0
20kawasaki disease10.0
21n syndrome10.0
22aplastic anemia10.0
23hemolytic anemia10.0
24ischemic heart disease10.0
25thalassemia10.0
26vascular cancer10.0
27familial adenomatous polyposis10.0NAT2
285-fluorouracil toxicity10.0DPYD
29crigler najjar syndrome, type 210.0UGT1A1, UGT1A4
30glucosephosphate dehydrogenase deficiency10.0UGT1A1, G6PD
31diarrhea10.0UGT1A1, UGT1A6, DPYD
32alpha thalassemia10.0UGT1A1, G6PD
33bilirubin metabolic disorder10.0G6PD, UGT1A7, UGT1A, UGT1A1
34autoimmune hepatitis10.0TPMT, UGT1A9, UGT1A1
35neutropenia10.0TPMT, DPYD, UGT1A1, UGT1A6
36pancreatitis10.0UGT1A7, TPMT
37galactosemia10.0G6PD, TPMT, UGT1A1, UGT2B4
38leukopenia10.0UGT1A1, DPYD, TPMT
39colon cancer10.0NAT2, DPYD, UGT1A1, UGT1A
40hepatocellular carcinoma10.0UGT1A9, NAT2, DPYD, UGT1A7, UGT1A, UGT1A1
41colorectal cancer10.0UGT1A7, UGT1A1, UGT1A6, TPMT, UGT1A9, DPYD
42lung cancer10.0UGT1A7, NAT2, UGT1A1, UGT1A, DPYD

Graphical network of the top 20 diseases related to Gilbert Syndrome:



Diseases related to gilbert syndrome

Clinical Features for Gilbert Syndrome

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46OMIM
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Clinical features from OMIM:

143500

Clinical synopsis from OMIM:

143500

Drugs & Therapeutics for Gilbert Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Gilbert Syndrome

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Genetic Tests for Gilbert Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Gilbert Syndrome:

id Genetic test Affiliating Genes
1 Gilbert Syndrome20 UGT1A1
2 Gilbert's Syndrome22

Anatomical Context for Gilbert Syndrome

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32MalaCards
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MalaCards organs/tissues related to Gilbert Syndrome:

32
Liver, Testes, Skin, Eye, Heart, Breast, Endothelial

Animal Models for Gilbert Syndrome or affiliated genes

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Publications for Gilbert Syndrome

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50PubMed
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Articles related to Gilbert Syndrome:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Crigler-Najjar syndrome type I in a Turkish newborn caused by a novel mutation and Gilbert type genetic defect. (24341141)
2013
2
Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects. (22325916)
2012
3
Severe jaundice in two children with Kawasaki disease: a possible association with Gilbert syndrome. (22219623)
2012
4
Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. (22521902)
2012
5
Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. (21412181)
2011
6
Snapback primer genotyping of the Gilbert syndrome UGT1A1 (TA)(n) promoter polymorphism by high-resolution melting. (21771946)
2011
7
Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome). (20955959)
2010
8
Gilbert syndrome in Iran, Fars Province. (20103965)
2010
9
Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome. (20529348)
2010
10
Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population. (19309288)
2009
11
Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin. (18343383)
2008
12
Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates. (18004206)
2007
13
Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes. (17895455)
2007
14
Gilbert syndrome presenting in a young boy, confirmed by the rifampin test. (17877076)
2007
15
Urinary excretion of oxidative metabolites of bilirubin in subjects with Gilbert syndrome. (17565639)
2007
16
Severe hyperbilirubinemia in a 10-year-old girl with a combined disorder of hereditary spherocytosis and Gilbert syndrome. (17587286)
2007
17
Coinheritance of Gilbert syndrome-associated UGT1A1 mutation increases gallstone risk in cystic fibrosis. (16557566)
2006
18
Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia: genetic screening is unnecessary. (16652295)
2006
19
Decreased levels of advanced glycation end-products in patients with Gilbert syndrome. (16309589)
2005
20
The polymorphism c.-3279T>G in the phenobarbital-responsive enhancer module of the bilirubin UDP-glucuronosyltransferase gene is associated with Gilbert syndrome. (16244305)
2005
21
Use of fully denaturing HPLC for UGT1A1 genotyping in Gilbert syndrome. (16244298)
2005
22
Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. (16170755)
2005
23
Gilbert syndrome as differential diagnosis of hyperbilirubinemia in acquired aplastic anemia. (15459961)
2005
24
Increased prevalence of cholelithiasis in Gaucher disease: association with splenectomy but not with gilbert syndrome. (15232362)
2004
25
A new case of (TA)8 allele in the UGT1A1 gene promoter in a Caucasian girl with Gilbert syndrome. (15205079)
2004
26
Two linked polymorphic mutations (A(TA)7TAA and T-3279G) of UGT1A1 as the principal cause of Gilbert syndrome. (15378351)
2004
27
Simultaneous presence of Gilbert syndrome and hereditary spherocytosis: interaction in the pathogenesis of hyperbilirubinemia and gallstone formation. (14631626)
2003
28
TATA-Box polymorphism in the uridine diphosphate glucuronosyl transferase gene in Portuguese patients with clinical diagnosis of Gilbert Syndrome. (11940506)
2002
29
Gilbert disease and type I and II Crigler-Najjar syndrome due to mutations in the same UGT1A1 gene locus]. (12371080)
2002
30
Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. (11849670)
2002
31
Presence of the genetic marker for Gilbert syndrome is associated with increased level and duration of neonatal jaundice. (11883809)
2002
32
Re: unusual early presentation of Gilbert syndrome in pediatric recipients of liver transplantation. (11345189)
2001
33
Gilbert syndrome revealed during chemotherapy. (11241448)
2001
34
Hyperbilirubinaemia, glucose-6-phosphate dehydrogenase deficiency and Gilbert syndrome. (11277384)
2001
35
Unusual early presentation of Gilbert syndrome in pediatric recipients of liver transplantation. (10997365)
2000
36
Melting temperature assay for a UGT1A gene variant in Gilbert syndrome. (10702534)
2000
37
Rapid method for detection of extra (TA) in the promoter of the bilirubin-UDP-glucuronosyl transferase 1 gene associated with Gilbert syndrome. (10620585)
2000
38
Distribution of the A(TA)7TAA genotype associated with Gilbert syndrome in the Spanish population]. (11141380)
2000
39
Coinheritance of Gilbert syndrome increases the risk for developing gallstones in patients with hereditary spherocytosis. (10498597)
1999
40
Jaundice with hypertrophic pyloric stenosis as an early manifestation of Gilbert syndrome. (10490432)
1999
41
Contribution of the TATA-box genotype (Gilbert syndrome) to serum bilirubin concentrations in the Italian population. (10352000)
1999
42
Benign congenital jaundice (hyperbilirubinemia): a case of Gilbert syndrome. (9592443)
1998
43
Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia. (9342374)
1997
44
Kernicterus in an adult who is heterozygous for Crigler-Najjar syndrome and homozygous for Gilbert-type genetic defect. (9178703)
1997
45
Gilbert syndrome. (8716954)
1996
46
The role of reduced calorie intake test in diagnosing Gilbert syndrome--a case report. (8107165)
1993
47
Jaundice with hypertrophic pyloric stenosis: a possible early manifestation of Gilbert syndrome. (2738801)
1989
48
Identifying the gilbert syndrome. (18748488)
1979
49
Marked hyperbilirubinemia with Gilbert syndrome and immunohemolytic anemia. (712491)
1978
50
Gilbert syndrome and factor-VII deficiency. (4194152)
1970

Genetic Variations for Gilbert Syndrome

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Expression for genes affiliated with Gilbert Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gilbert Syndrome

Search GEO for disease gene expression data for Gilbert Syndrome.

Pathways for genes affiliated with Gilbert Syndrome

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG
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Pathways related to Gilbert Syndrome according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3UGT1A1, CYP2C8
210.2NAT2, CYP2C8
310.2UGT1A4, UGT1A9, NAT2
4
Hide members
10.1UGT2B10, UGT1A4, UGT1A9
5
Hide members
10.1UGT1A9, UGT1A1, CYP2C8
6
Hide members
10.1UGT1A6, CYP2C8, UGT1A9
710.0UGT1A6, UGT1A9, UGT1A4, UGT1A3
8
Hide members
10.0UGT1A9, UGT1A3, CYP2C8, UGT1A1
9
Hide members
10.0UGT1A3, UGT1A9, UGT1A4, UGT1A1, UGT1A6
10
Hide members
9.9UGT1A1, CYP2C8, UGT1A6, UGT1A4, UGT1A9
11
Acetaminophen metabolism
Hide members
9.9UGT1A1, UGT1A4, UGT1A6, NAT2, UGT1A3, UGT1A9
12
Hide members
9.7UGT1A9, UGT1A6, UGT1A4, UGT1A1, UGT1A7, UGT1A3
13
Hide members
9.4UGT1A9, UGT1A4, UGT2B4, UGT1A1, UGT2B28, UGT1A3
14
Hide members
8.9UGT2A3, UGT1A7, UGT2B10, UGT1A3, UGT2A1, UGT2B11
15
Hide members
8.8CYP2C8, UGT1A9, UGT2B11, UGT2A1, UGT1A3, UGT2B10
16
Hide members
8.7G6PD, UGT1A1, UGT1A9, UGT1A4, UGT2B4, UGT1A6
17
Hide members
8.7UGT2B11, UGT2A1, UGT1A3, UGT2B10, UGT1A7, UGT2A3

Compounds for genes affiliated with Gilbert Syndrome

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11DrugBank, 44Novoseek, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Gilbert Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1Ezogabine 1110.3UGT1A1, UGT1A3, NAT2, UGT1A4, UGT1A9
2sn38 glucuronide4410.3UGT1A1, UGT1A7, UGT1A, UGT1A9
3lamotrigine44 1111.2UGT1A, UGT1A4, UGT1A6, UGT1A1, UGT1A3
41-naphthol4410.2UGT2B4, UGT1A1, UGT1A9, UGT1A6, UGT1A
5phip4410.2UGT1A1, UGT1A4, UGT1A, UGT1A9, NAT2
6benzidine4410.2UGT1A6, UGT1A, UGT1A9, UGT1A4, UGT1A1, NAT2
74-methylumbelliferone4410.2UGT1A1, UGT1A9, UGT1A, UGT1A6
8n-hydroxy phip4410.2UGT1A7, UGT1A, UGT1A9, UGT1A4, UGT1A6, UGT1A1
9sn 3844 5911.2UGT1A1, UGT1A7, UGT1A, DPYD, UGT1A9
10phenol44 2411.2G6PD, NAT2, UGT1A1, UGT1A6, UGT1A9, UGT1A
11flurbiprofen44 28 49 1113.2UGT1A, UGT1A9, UGT2B4, UGT1A1, UGT1A3
12buprenorphine44 28 1112.1UGT1A9, UGT1A1, UGT1A3, CYP2C8, UGT1A
13ethyl glucuronide44 2411.1UGT1A1, UGT1A7, UGT1A3, UGT1A6, UGT2B4, UGT1A9
14benzo(a)pyrene4410.1UGT1A1, UGT1A6, UGT1A9, UGT1A7, NAT2, UGT1A
15udp glucuronic acid4410.1UGT1A6, UGT2B4, UGT1A1, UGT1A
16imipramine44 49 28 11 2414.1UGT1A9, UGT1A7, UGT1A4, UGT1A6, UGT1A, UGT1A1
17trifluoperazine44 28 1112.1UGT1A1, UGT1A6, UGT1A9, UGT1A4, UGT1A
18propofol44 49 1112.1UGT1A4, UGT1A, UGT1A9, UGT1A3, UGT1A6, UGT1A1
19irinotecan44 49 1112.1DPYD, UGT1A9, UGT1A6, UGT1A1, UGT1A7, TPMT
20p-nitrophenol44 1111.1UGT1A, UGT1A4, UGT2B4, UGT1A9, UGT1A6, UGT1A1
21amine4410.0UGT1A3, UGT1A, UGT1A1, UGT1A7, NAT2, UGT1A4
22diclofenac44 28 49 1113.0CYP2C8, UGT1A3, UGT1A1, UGT1A4, UGT1A9, UGT1A
23sulfamethoxazole44 49 1112.0G6PD, UGT1A9, NAT2, CYP2C8
24cotinine44 2411.0NAT2, UGT1A3, UGT1A7, UGT1A1, UGT1A6, UGT1A4
25glucuronide4410.0UGT1A, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1
26troglitazone44 28 59 1113.0UGT1A9, CYP2C8, UGT1A3, UGT1A1, UGT1A6, UGT1A4
27mycophenolate mofetil44 49 1112.0UGT1A, UGT1A9, TPMT, CYP2C8, UGT1A1
28valproic acid44 49 11 2413.0UGT1A7, UGT1A1, UGT1A6, UGT1A, UGT1A3, UGT1A9
29epoxide449.9UGT1A, NAT2, CYP2C8, UGT1A7, UGT1A1
30morphine44 49 28 1112.9UGT1A3, CYP2C8, UGT1A6, UGT1A4, UGT1A9, UGT1A
31uridine44 11 2411.9UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT1A7
32uridine diphosphate449.9UGT1A1, UGT1A7, UGT1A3, DPYD, NAT2, TPMT
33nicotine44 49 28 1112.8CYP2C8, UGT1A, UGT2B10, UGT1A7, UGT1A1, UGT1A6
34rifampicin44 28 5911.8UGT1A1, NAT2, CYP2C8, UGT1A6, UGT1A
35acetaminophen44 2 49 11 2413.8UGT2B4, NAT2, G6PD, UGT1A, UGT1A9, UGT1A4
36tamoxifen44 49 28 1112.8UGT1A4, UGT2B4, UGT1A6, UGT1A1, CYP2C8, UGT1A3
37ibuprofen44 28 49 11 2413.6CYP2C8, UGT1A3, UGT1A1, UGT2B4, UGT1A9
38etiocholanolone44 2410.5UGT1A7, UGT2B10, UGT1A3, UGT2A1, UGT2B11, UGT1A9
393-alpha-androstanediol glucuronide44 2410.5UGT1A6, UGT1A1, UGT2B28, UGT2A3, UGT1A7, UGT2B10
40estriol28 11 2411.5UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT2B28, UGT2A3
41androsterone glucuronide44 2410.5UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
422-methoxyestradiol44 59 2411.5UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
43(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)249.5UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
44bilirubin diglucuronide44 2410.5UGT2B10, UGT1A3, UGT2A1, UGT2B11, UGT1A7, UGT2A3
45aldosterone 18-glucuronide44 2410.5UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
46codeine44 49 28 11 2413.3UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
47estrone44 28 11 2412.2UGT1A, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1
48estradiol44 11 2411.2UGT1A, UGT2B10, CYP2C8, UGT2B11, UGT1A3, UGT1A9
49retinoic acid44 2410.2UGT1A, UGT2A1, UGT1A3, UGT1A7, UGT2A3, UGT2B28
50testosterone44 59 11 2412.1UGT1A, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1

GO Terms for genes affiliated with Gilbert Syndrome

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16Gene Ontology
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Cellular components related to Gilbert Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:04323110.0UGT1A6, UGT2B4, UGT1A9, G6PD
2endoplasmic reticulum membraneGO:0057899.1CYP2C8, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1
3integral to membraneGO:0160218.5UGT3A2, UGT1A6, UGT2B4, UGT1A4, UGT1A9, UGT2B28

Biological processes related to Gilbert Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1xenobiotic glucuronidationGO:05269710.3UGT1A1, UGT1A3, UGT1A7, UGT1A9
2flavone metabolic processGO:05155210.3UGT1A7, UGT1A1, UGT1A9
3flavonoid glucuronidationGO:05269610.3UGT1A7, UGT1A1, UGT1A9, UGT1A3
4estrogen metabolic processGO:00821010.2UGT1A1, UGT2B11
5retinoic acid metabolic processGO:04257310.2UGT1A9, UGT1A1, UGT1A7, UGT1A3
6drug metabolic processGO:01714410.2UGT1A9, UGT1A1, UGT1A7, CYP2C8
7negative regulation of catalytic activityGO:04308610.1UGT1A1, UGT1A9, UGT1A7
8cellular glucuronidationGO:05269510.0UGT2B4, UGT1A6, UGT1A1, UGT2A3, UGT2A1, UGT1A4
9negative regulation of fatty acid metabolic processGO:04592210.0UGT1A7, UGT1A9
10metabolic processGO:00815210.0UGT1A9, UGT2A1, UGT1A3, UGT2B28, UGT1A6, UGT2B4
11xenobiotic metabolic processGO:0068059.6TPMT, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1
12small molecule metabolic processGO:0442819.5UGT1A4, TPMT, UGT1A1, NAT2, CYP2C8, G6PD

Molecular functions related to Gilbert Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1UDP-glycosyltransferase activityGO:00819410.2UGT1A3, UGT3A2
2enzyme inhibitor activityGO:0048579.9UGT1A7, UGT1A1, UGT1A9
3enzyme bindingGO:0198999.9UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A7, UGT1A3
4retinoic acid bindingGO:0019729.8UGT1A6, UGT1A7, UGT2B4, UGT1A4, UGT1A9, UGT1A3
5protein heterodimerization activityGO:0469829.8UGT1A4, UGT1A6, UGT1A1, UGT1A7, UGT1A3, UGT1A9
6protein homodimerization activityGO:0428039.7UGT1A7, UGT1A3, DPYD, G6PD, UGT1A1, UGT1A6
7glucuronosyltransferase activityGO:0150209.1UGT1A9, UGT1A3, UGT2B10, UGT1A7, UGT2A3, UGT2B28

Products for genes affiliated with Gilbert Syndrome

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Sources for Gilbert Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet