Gilbert Syndrome malady

Genetics Home Reference: Gilbert syndrome is a relatively mild condition characterized by periods of elevated levels of a toxic substance called bilirubin in the blood (hyperbilirubinemia). Bilirubin, which has an orange-yellow tint, is produced when red blood cells are broken down. This substance is removed from the body only after it undergoes a chemical reaction in the liver, which converts the toxic form of bilirubin (unconjugated bilirubin) to a nontoxic form called conjugated bilirubin. People with Gilbert syndrome have a buildup of unconjugated bilirubin in their blood (unconjugated hyperbilirubinemia). In affected individuals, bilirubin levels fluctuate and very rarely increase to levels that cause jaundice, which is yellowing of the skin and whites of the eyes.¹⁷

MalaCards: Gilbert Syndrome, also known as gilbert's syndrome, is related to crigler-najjar syndrome and kernicterus. An important gene associated with Gilbert Syndrome is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are Glucuronidation and Valproic Acid Pathway, Pharmacokinetics. The drugs phenobarbital and phenobarbital sodium and the compounds cyclophosphamide and n-hydroxy phip have been mentioned in the context of this disorder. Affiliated tissues include liver and skin, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Disease Ontology: A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity.⁶

Wikipedia: Gilbert\'s syndrome (/ʒiːlˈbɛər/zheel-BAIR), often shortened to GS, also called...⁴⁴ more...

OMIM: 143500

Aliases & Descriptions:

gilbert syndrome 6 17 33 8 gilbert's syndrome 6 16 unconjugated benign bilirubinemia 17 constitutional hyperbilirubinemia 6 hereditary nonhemolytic jaundice 6 constitutional liver dysfunction 17 familial nonhemolytic jaundice 17 gilbert-meulengracht syndrome 6

gilbert disease (disorder) 43 hyperbilirubinemia type i 16 meulengracht syndrome 17 hyperbilirubinemia 1 17 hyperbilirubinemia 43 gilbert's disease 6 gilberts syndrome 32 rotor syndrome 43

Diseases related to gilbert syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 289)

id	Related Disease	Score	Top Affiliating Genes
1	crigler-najjar syndrome	31.9	CNDP2, UGT1A, UGT1A1, UGT1A4, UGT1A6, UGT1A9
2	kernicterus	30.9	UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9
3	bilirubin metabolic disorder	29.7	SELP, IGF1, G6PD, DPYD, NEU1
4	carcinoid syndrome	29.2	VEGFA, UGT1A1, IGF1
5	jaundice	28.9	UGT1A, UGT1A1, UGT1A4, IGF1, HMOX1, G6PD
6	neonatal jaundice	28.6	UGT1A1, HMOX1, G6PD, SLCO1B1
7	hemolytic anemia	28.1	UGT1A1, CD40LG, HMOX1, G6PD
8	cholelithiasis	28.0	UGT1A1, UGT1A6, UGT2B4, CD40LG, HMOX1, G6PD
9	hepatitis a	27.4	SERPINC1, CD40LG, CYP3A4, G6PD, NEU1
10	viral hepatitis	27.4	SERPINC1, UGT1A, CD40LG, CYP3A4, G6PD, DPYD
11	beta thalassemia	26.5	SERPINC1, UGT1A, UGT1A1, IGF1, CYP1A2, CYP3A4
12	sickle cell anemia	26.3	SELP, UGT1A1, CD40LG, IGF1, G6PD
13	thalassemia	25.9	SERPINC1, UGT1A, UGT1A1, IGF1, HMOX1, CYP1A2
14	thrombocytopenia	25.4	SELP, SERPINC1, CD40LG, TPMT, DPYD, NEU1
15	esophageal cancer	24.7	NAT2, VEGFA, KDR, IGF1, CYP1A2, ABCB1
16	hearing loss	23.9	SERPINC1, UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7
17	purpura	23.5	SELP, SERPINC1, VEGFA, CD40LG, IGF1, HMOX1
18	hepatitis c	23.3	SELP, SERPINC1, VEGFA, KDR, UGT1A1, UGT1A7
19	atherosclerosis	23.3	SELP, SERPINC1, NAT2, VEGFA, KDR, UGT1A1
20	cholestasis	23.1	SERPINC1, VEGFA, UGT1A3, IGF1, CYP3A4, CYP3A5
21	anemia	22.5	SELP, SERPINC1, VEGFA, KDR, UGT1A1, CD40LG
22	cystic fibrosis	22.2	SELP, SERPINC1, NAT2, VEGFA, UGT1A1, CD40LG
23	hepatitis b	22.1	SERPINC1, NAT2, VEGFA, UGT1A7, CD40LG, IGF1
24	fibrosis	21.2	SELP, SERPINC1, NAT2, VEGFA, KDR, UGT1A1
25	esophagitis	20.9	SERPINC1, NAT2, VEGFA, KDR, UGT1A4, UGT1A6
26	hepatitis	20.4	SELP, SERPINC1, NAT2, VEGFA, KDR, UGT1A
27	crigler najjar syndrome, type 2	13.7	UGT1A, UGT1A1
28	glucosephosphate dehydrogenase deficiency	13.5	UGT1A1, G6PD, SLCO1B1
29	5-fluorouracil toxicity	13.5	UGT1A1, ABCB1, DPYD
30	kawasaki disease	13.4	UGT1A9, HMOX1
31	drug-induced hepatitis	13.3	NAT2, UGT1A1, UGT1A3, UGT1A6, B3GAT2
32	hyperlipoproteinemia type iii	13.2	CD40LG, G6PD, NEU1
33	warfarin sensitivity	13.1	TMBIM4, CYP1A2, CYP3A5, ABCB1
34	pulmonary arteriovenous malformation	13.1	HMOX1, HIF1A
35	fascioliasis	13.1	UGT2B11, CYP3A4, CYP3A5
36	antley-bixler syndrome	13.1	CYP1A2, CYP3A4, CYP3A5
37	autoimmune hepatitis	13.0	UGT1A1, UGT1A9, CD40LG, TPMT, CYP1A2
38	testicular germ cell cancer	12.9	CYP1A2, CYP3A4, CYP3A5, ABCB1
39	tardive dyskinesia	12.8	CYP1A2, CYP3A4, CYP3A5, ABCB1
40	li-fraumeni syndrome	12.8	NAT2, IGF1, G6PD, HIF1A
41	prolymphocytic leukemia	12.8	VEGFA, CD40LG, ABCB1
42	monoclonal gammopathy of undetermined significance	12.8	CD40LG, IGF1, NEU1
43	estrogen-receptor positive breast cancer	12.8	VEGFA, UGT1A, UGT2B15, CYP3A4
44	intrahepatic cholestasis	12.7	CYP3A4, ABCB1, HIF1A, SLCO1B1
45	pandas	12.7	UGT1A7, CD40LG, HMOX1, CYP1A2, G6PD
46	retinal vascular disease	12.7	VEGFA, KDR, NEU1
47	brain glioma	12.7	IGF1, ABCB1, HIF1A
48	growth hormone deficiency	12.7	NAT2, CD40LG, IGF1, CYP1A2
49	variegate porphyria	12.7	HMOX1, CYP1A2, CYP3A4, CYP3A5
50	gallbladder carcinoma	12.7	NAT2, VEGFA, ABCB1, DPYD

Clinical features from OMIM: 143500

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 phenobarbital, phenobarbital sodium

Genetic tests related to gilbert syndrome:

id	Genetic test	Affiliating Genes
1	Gilbert Syndrome clinical/research	UGT1A, UGT1A1

MalaCards organs/tissues related to gilbert syndrome:

²²

MGI Mouse Phenotypes related to gilbert syndrome:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.3	TPMT
2	liver/biliary system phenotype	MP:0005370	8.0	SERPINC1, VEGFA, CYP1A2, ABCB1, HIF1A
3	cardiovascular system phenotype	MP:0005385	5.7	HIF1A, G6PD, ABCB1, CYP1A2, HMOX1, IGF1
4	homeostasis/metabolism phenotype	MP:0005376	4.5	CYP1A2, ABCB1, ABCG2, G6PD, HIF1A, NEU1

Articles related to gilbert syndrome:

(show top 50)    (show all 72)

id	Title	Authors	Year	Affiliating Genes
1	Rapid UGT1A1 (TA)(n) genotyping by high resolution me lting curve analysis for Gilbert's syndrome diagnosis. (19932091)	Minucci A.... Capoluongo E.	2010	UGT1A1
2	Pegvisomant-induced liver injury is related to the UG T1A1*28 polymorphism of Gilbert's syndrome. (20207827)	Bernabeu I.... Casanueva F.F.	2010	UGT1A1
3	Pazopanib-induced hyperbilirubinemia is associated wi th Gilbert's syndrome UGT1A1 polymorphism. (20389299)	Xu C.F.... Pandite L.	2010	KDR, VEGFA, ABCG2
4	Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment. (19303655)	Lankisch T.O.... Strassburg C.P.	2009	UGT1A1, UGT1A3, UGT1A7
5	Gilbert's syndrome and antiviral therapy of hepatitis C. (19841506)	Deterding K.... Strassburg C.P.	2009	UGT1A1
6	Pegvisomant-induced cholestatic hepatitis with jaundice in a patient with Gilbert's syndrome. (19258431)	Bernabeu I.... Marazuela M.	2009	IGF1
7	Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. (18349289)	Lankisch T.O.... Strassburg C.P.	2008	UGT1A1, UGT1A7
8	Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin. (18343383)	Schwertner H.A.... Vitek L.	2008	HMOX1, UGT1A1
9	Dual polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: a novel mechanism for hyperserotoninaemia in Gilbert's syndrome mimicking carcinoid syndrome? (17353700)	Lee P.... Seibel M.J.	2007	UGT1A1
10	Combined UGT1A1 and UGT1A7 variant alleles are associated with increased risk of Gilbert's syndrome in Taiwanese adults. (17850628)	Teng H.C.... Huang C.S.	2007	UGT1A1, UGT1A7, UGT1A
11	Molecular pathogenesis of Gilbert's syndrome: decreased TATA-binding protein binding affinity of UGT1A1 gene promoter. (17496722)	Hsieh T.Y.... Chao Y.C.	2007	UGT1A1
12	Coinheritance of Gilbert syndrome-associated UGT1A1 mutation increases gallstone risk in cystic fibrosis. (16557566)	Wasmuth H.E.... Lammert F.	2006	UGT1A1
13	Gilbert's syndrome: High frequency of the (TA)7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene. (16610035)	Farheen S.... Chowdhury A.	2006	UGT1A1
14	Linkage between A(TA)7TAA and -3279T>G mutations in UGT1A1 is not essential for pathogenesis of Gilbert syndrome. (17105600)	Jirsa M.... Vitek L.	2006	UGT1A1
15	Combined test for UGT1A1 -3279T-->G and A(TA)nTAA polymorphisms best predicts Gilbert's syndrome in Italian pediatric patients. (16792515)	Ferraris A.... Dallapiccola B.	2006	UGT1A1
16	Glucose-6-phosphate dehydrogenase deficiency and Gilbert syndrome: a gene interaction underlies severe jaundice without severe hemolysis. (16166048)	Nicolaidou P.... Stamoulakatou A.	2005	G6PD
17	What is Gilbert's syndrome? Lesson from genetic polymorphisms of UGT1A1 in Gilbert's syndrome from Asia. (15304109)	Kamisako T.	2004	UGT1A1
18	A new case of (TA)8 allele in the UGT1A1 gene promoter in a Caucasian girl with Gilbert syndrome. (15205079)	Coelho H.... Barbot J.	2004	UGT1A1
19	Two linked polymorphic mutations (A(TA)7TAA and T-3279G) of UGT1A1 as the principal cause of Gilbert syndrome. (15378351)	Maruo Y.... Takeuchi Y.	2004	UGT1A1
20	Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects. (15304120)	Takeuchi K.... Adachi Y.	2004	UGT1A1
21	Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. (12732365)	Kohle C.... Bock K.W.	2003	UGT1A1, UGT1A6, UGT1A7
22	Glucose-6-phosphate dehydrogenase deficiency, neonatal hyperbilirubinemia and Gilbert syndrome (12680285)	Costa E.... Barbot J.	2002	G6PD, UGT1A1
23	A study of polymorphism in UDP-glucuronosyltransferase 1 (UGT-1A1) promoter gene in Korean patients with Gilbert's syndrome (12499798)	Kim Y.H.... Lee C.H.	2002	UGT1A1
24	Novel missense mutation of the UGT1A1 gene in Thai siblings with Gilbert's syndrome. (12139570)	Sutomo R.... Nishio H.	2002	UGT1A1, UGT1A9
25	Neonatal hyperbilirubinemia and Gilbert's syndrome. (12012638)	Laforgia N.... Iolascon A.	2002	UGT1A4
26	From gene to disease; unconjugated hyperbilirubinemia: Gilbert's syndrome and Crigler-Najjar types I and II (12198827)	Drenth J.P.... Jansen J.B.	2002	UGT1A1
27	A case of congenital dyserythropoietic anemia type II, Gilbert's syndrome and malleolar trophic ulcers. (12243985)	Bordi B.... Tirelli A.	2002	SERPINC1
28	Predicting the risk of sporadic elevated bilirubin levels and diagnosing Gilbert's syndrome by genotyping UGT1A1*28 promoter polymorphism. (12078936)	Rauchschwalbe S.K.... Kuhlmann J.	2002	UGT1A1
29	Chronic hemolytic anemia associated with glucose 6-phosphate dehydrogenase (Guadalajara)1 159 C --> T (387 Arg --> Cys) deficiency associated with Gilbert syndrome in a Turkish patient. (11787865)	Oner R.... Altay C.	2002	G6PD
30	Correlation of mutational analysis to clinical features in Taiwanese patients with Gilbert's syndrome. (11316168)	Hsieh S.Y.... Liaw Y.F.	2001	UGT1A1
31	Genetic interactions in the pathogenesis of neonatal hyperbilirubinemia: Gilbert's Syndrome and glucose-6-phosphate dehydrogenase deficiency. (11803413)	Kaplan M.	2001	G6PD, UGT1A
32	Hyperbilirubinaemia, glucose-6-phosphate dehydrogenase deficiency and Gilbert syndrome. (11277384)	Kaplan M.... Beutler E.	2001	G6PD
33	Gilbert syndrome associated with beta-thalassemia. (11764096)	Tzetis M.... Kitsiou-Tzeli S.	2001	UGT1A1
34	Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects. (11003624)	Borlak J.... Hermann R.	2000	UGT1A1
35	Gilbert's syndrome and jaundice in glucose-6-phosphate dehydrogenase deficient neonates. (11114816)	Kaplan M.	2000	G6PD
36	Distribution of the A(TA)7TAA genotype associated with Gilbert syndrome in the Spanish population (11141380)	Fernandez Salazar J.M.... Baiget Bastus M.	2000	UGT1A1
37	Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype. (11013440)	Kadakol A.... Chowdhury N.R.	2000	UGT1A1, UGT1A9, UGT1A
38	Disposition of propafenone in a poor metabolizer of CYP2D6 with Gilbert's syndrome. (10850406)	Dilger K.... Eichelbaum M.	2000	UGT1A1
39	Coinheritance of Gilbert syndrome increases the risk for developing gallstones in patients with hereditary spherocytosis. (10498597)	del Giudice E.M.... Iolascon A.	1999	UGT1A1
40	Bilirubin levels in the acute hemolytic crisis of G6PD deficiency are related to Gilbert's syndrome. (10359058)	Iolascon A.... del Giudice E.M.	1999	G6PD, UGT1A1
41	Gilbert's syndrome and jaundice in glucose-6-phosphate dehydrogenase deficient neonates. (10091404)	Iolascon A.... del Giudice E.M.	1999	G6PD
42	Use of double gradient denaturing gradient gel electrophoresis to detect (AT)n polymorphisms in the UDP-glucuronosyltransferase 1 gene promoter associated with Gilbert's syndrome. (10546817)	GA1rtler V.... Mayall B.C.	1999	UGT1A1
43	The interaction between Gilbert's syndrome and G6PD d eficiency influences bilirubin levels. (10192462)	Cappellini M.D.... FIORELLI G.	1999	G6PD
44	Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn. (10190918)	Monaghan G.... Burchell B.	1999	UGT1A1
45	(TA)8 allele in the UGT1A1 gene promoter of a Caucasian with Gilbert's syndrome. (10091406)	Iolascon A.... Savoia A.	1999	UGT1A1
46	Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler-Najjar syndrome type II. (9630669)	Yamamoto K.... Bamba T.	1998	UGT1A1
47	Gilbert syndrome caused by a homozygous missense mutation (Tyr486Asp) of bilirubin UDP-glucuronosyltransferase gene. (9627603)	Maruo Y.... Shimada M.	1998	UGT1A1, UGT1A9
48	Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia. (9342374)	Kaplan M.... Beutler E.	1997	G6PD
49	Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome. (7715297)	Aono S.... Sato H.	1995	UGT1A1, UGT1A9, UGT1A
50	Familial increased serum intestinal alkaline phosphatase: a new variant associated with Gilbert's syndrome. (2318988)	Lieverse A.G.... Weits J.	1990	NEU1

Genes related to gilbert syndrome according to GeneCards:

(show all 34)

id	Symbol	Description	Score	GeneCards Section Context
1	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	11.1	Summaries, Publications
2	UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	11.0	Publications
3	UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	11.0	Publications
4	UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A complex locus	11.0	Publications
5	TPMT	thiopurine S-methyltransferase	11.0
6	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
7	DPYD	dihydropyrimidine dehydrogenase	11.0
8	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
9	UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	11.0	Publications
10	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	11.0	Publications
11	UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	11.0	Publications
12	UGT2B10	UDP glucuronosyltransferase 2 family, polypeptide B10	11.0
13	UGT2B11	UDP glucuronosyltransferase 2 family, polypeptide B11	11.0
14	TMBIM4	transmembrane BAX inhibitor motif containing 4	11.0
15	CNDP2	CNDP dipeptidase 2 (metallopeptidase M20 family)	11.0
16	B3GAT2	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)	11.0
17	UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	11.0
18	UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	11.0
19	CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	11.0	Publications
20	SLCO1B1	solute carrier organic anion transporter family, member 1B1	11.0	Publications
21	CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	11.0	Publications
22	NEU1	sialidase 1 (lysosomal sialidase)	11.0	Publications
23	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0	Publications
24	CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	11.0	Publications
25	CD40LG	CD40 ligand	11.0	Publications
26	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	11.0	Publications
27	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
28	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
29	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
30	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
31	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0	Publications
32	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
33	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
34	VEGFA	vascular endothelial growth factor A	11.0	Publications

Pathways related to gilbert syndrome according to GeneDecks:

(show top 50)    (show all 71)

id	Pathway	Score	Top Affiliating Genes
1	Glucuronidation38	10.1	UGT1A6, UGT1A4, UGT1A1
2	Valproic Acid Pathway, Pharmacokinetics34	10.0	UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B15
3	Sorafenib Pharmacokinetics34	10.0	CYP2C8, CYP3A4, UGT1A9, UGT1A1
4	Estrogen Metabolism Pathway34	10.0	CYP1A2, UGT1A9, UGT1A4, UGT1A3, UGT1A1
5	Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics34	9.9	SLCO1B1, CYP2C8, CYP3A4
6	Caffeine Pathway, Pharmacokinetics34	9.8	NAT2, CYP1A2, CYP3A4, CYP2C8
7	Codeine and Morphine Pathway, Pharmacokinetics34	9.8	SLCO1B1, ABCB1, CYP3A4, UGT1A1
8	Ifosfamide Pathway, Pharmacokinetics34	9.7	CYP3A5, CYP2C8, CYP3A4
9	Cyclophosphamide Pathway, Pharmacokinetics34	9.7	CYP3A4, CYP2C8, CYP3A5
10	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics34	9.7	ABCG2, CYP3A5, CYP3A4, CYP1A2
11	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	9.7	ABCB1, CYP3A5, CYP3A4, UGT1A1
12	Artemisinin and Derivatives Pathway, Pharmacokinetics34	9.7	CYP3A5, CYP3A4, UGT1A9
13	Benzo[a]pyrene metabolism41	9.7	CYP2C8, CYP3A4, CYP1A2, UGT1A9, UGT1A6
14	Benzo[a]pyrene metabolism10	9.7	CYP2C8, CYP3A4, CYP1A2, UGT1A9, UGT1A6
15	Warfarin Pathway, Pharmacokinetics34	9.6	ABCB1, CYP2C8, CYP3A4, CYP1A2
16	Carbamazepine Pathway, Pharmacokinetics34	9.6	CYP1A2, CYP3A4, CYP2C8, CYP3A5
17	Clopidogrel Pathway, Pharmacokinetics34	9.6	ABCB1, CYP3A5, CYP3A4, CYP1A2
18	Fluvastatin Pathway, Pharmacokinetics34	9.6	SLCO1B1, CYP3A5, CYP2C8, CYP3A4, UGT1A3, UGT1A1
19	Gefitinib Pathway, Pharmacokinetics34	9.6	ABCG2, ABCB1, CYP3A5, CYP3A4
20	2-Naphthylamine and 2-Nitronaphtalene metabolism10	9.6	CYP3A4, CYP1A2, UGT1A9, UGT1A6, UGT1A4, UGT1A3
21	Tamoxifen Pathway, Pharmacokinetics34	9.6	CYP3A5, CYP3A4, CYP1A2, UGT2B15, UGT1A4, UGT1A3
22	2-Naphthylamine and 2-Nitronaphtalene metabolism41	9.6	CYP3A4, CYP1A2, UGT1A9, UGT1A6, UGT1A4, UGT1A3
23	Retinol metabolism10	9.6	CYP3A5, CYP2C8, CYP3A4, CYP1A2, UGT1A3
24	Estradiol metabolism41	9.5	CYP3A5, CYP2C8, CYP3A4, CYP1A2, UGT2B11, UGT1A1
25	Acetaminophen metabolism41	9.5	UGT1A3, UGT1A6, UGT1A9, UGT2B15, CYP1A2, CYP3A4
26	Estradiol metabolism10	9.5	CYP3A5, CYP2C8, CYP3A4, CYP1A2, UGT2B11, UGT1A1
27	Acetaminophen metabolism10	9.5	CYP3A4, UGT1A1, UGT1A3, UGT1A6, UGT1A9, UGT2B15
28	Retinol metabolism41	9.5	CYP3A5, CYP2C8, CYP3A4, CYP1A2, UGT1A3
29	Irinotecan Pathway, Pharmacodynamics34	9.5	ABCG2, UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9
30	Taxane Pathway, Pharmacokinetics34	9.4	ABCG2, ABCB1, CYP3A5, CYP2C8, CYP3A4
31	Ascorbate and aldarate metabolism20	9.3	UGT1A4, UGT1A3, UGT1A1, UGT1A6, UGT1A7, UGT2B4
32	Other types of O-glycan biosynthesis20	9.3	UGT2B4, UGT2B15, UGT2B11, UGT2B10, UGT1A9, UGT1A7
33	Starch and sucrose metabolism20	9.3	UGT1A3, UGT1A1, UGT1A4, UGT1A6, UGT2B4, UGT2B15
34	Pentose and glucuronate interconversions20	9.3	UGT2B4, UGT2B15, UGT2B11, UGT2B10, UGT1A9, UGT1A7
35	Phenytoin Pathway, Pharmacokinetics34	9.3	CYP3A4, CYP1A2, UGT1A9, UGT1A6, UGT1A4, UGT1A1
36	Benzodiazepine Pathway, Pharmacokinetics34	9.3	UGT2B15, UGT1A9, UGT1A4, NAT2, UGT2B4, CYP3A5
37	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics34	9.3	UGT1A3, CYP3A4, CYP2C8, CYP3A5, ABCB1, SLCO1B1
38	Irinotecan Pathway, Pharmacokinetics34	9.3	CYP3A4, UGT1A9, UGT1A1, CYP3A5, ABCB1, SLCO1B1
39	Bile secretion20	9.2	UGT2B4, CYP3A4, ABCB1, ABCG2, SLCO1B1
40	Linoleic acid metabolism20	9.2	CYP3A5, CYP2C8, CYP3A4, CYP1A2
41	Erlotinib Pathway, Pharmacokinetics34	9.1	ABCG2, ABCB1, CYP3A5, CYP2C8, CYP3A4, CYP1A2
42	Statin Pathway - Generalized, Pharmacokinetics34	9.0	SLCO1B1, ABCG2, ABCB1, CYP3A5, CYP2C8, CYP3A4
43	Mycophenolic acid Pathway, Pharmacokinetics34	9.0	SLCO1B1, ABCG2, ABCB1, CYP3A5, CYP2C8, CYP3A4
44	Steroid hormone biosynthesis20	8.8	CYP3A5, CYP3A4, UGT2B4, UGT2B15, UGT2B11, UGT2B10
45	Porphyrin and chlorophyll metabolism20	8.7	UGT1A4, UGT1A3, UGT1A1, UGT1A6, UGT1A7, HMOX1
46	Drug metabolism - other enzymes20	8.4	UGT2B11, UGT2B10, UGT1A9, UGT1A7, UGT1A6, UGT1A4
47	Metabolism of xenobiotics by cytochrome P45020	8.3	CYP3A4, UGT1A1, UGT1A3, UGT1A4, CYP1A2, UGT2B4
48	Retinol metabolism20	8.3	CYP3A5, CYP2C8, CYP3A4, CYP1A2, UGT2B4, UGT2B15
49	Drug metabolism - cytochrome P45020	8.3	UGT2B10, UGT1A9, UGT1A7, UGT1A6, UGT1A4, UGT1A3
50	Metabolic pathways20	7.7	UGT2B4, B3GAT2, CYP1A2, CYP3A4, CYP2C8, CYP3A5

Compounds related to gilbert syndrome according to GeneDecks:

(show top 50)    (show all 443)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.0	TPMT, CYP2C8
2	n-hydroxy phip32	10.0	NAT2, UGT1A, UGT1A1, UGT1A4, UGT1A6, UGT1A7
3	sn-3834	9.8	UGT1A3, UGT1A4, UGT1A1, UGT1A6, UGT1A7, UGT1A9
4	ethyl glucuronide32 18	10.6	UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9
5	cotinine32 18	10.6	UGT1A9, UGT2B15, UGT1A7, UGT1A6, UGT1A4, NAT2
6	glucuronide32	9.5	UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9, UGT2B15
7	bilirubin diglucuronide32 18	10.3	UGT2B10, UGT2B11, UGT2B15, UGT2B4, UGT1A9, UGT1A1
8	androsterone glucuronide32 18	10.3	UGT1A6, UGT1A7, UGT1A9, UGT2B10, UGT2B11, UGT2B15
9	etiocholanolone32 18	10.3	UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9
10	3-alpha-androstanediol glucuronide32 18	10.3	UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9
11	(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)18	9.3	UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9
12	uridine32 9 18 9	12.3	UGT2B15, UGT1A9, UGT1A7, UGT1A6, UGT1A4, UGT1A1
13	phip32	9.3	UGT1A1, UGT1A9, UGT1A, NAT2, ABCG2, UGT1A4
14	sn 3832 42	10.3	DPYD, UGT1A, UGT1A1, UGT1A7, UGT1A9, CYP3A4
15	aldosterone 18-glucuronide32 18	10.2	UGT1A3, UGT1A1, UGT1A4, UGT1A6, UGT2B4, UGT2B15
16	nicotine32 34 9 9	12.1	CYP2C8, UGT1A1, UGT1A4, UGT1A6, UGT1A9, UGT2B15
17	rifampin34 9 9	11.1	NAT2, UGT1A1, CYP1A2, CYP3A4, CYP2C8, CYP3A5
18	Estriol9 18 9	11.0	UGT2B11, UGT2B15, UGT2B4, ABCB1, UGT2B10, UGT1A9
19	p-nitrophenol32 9 9	10.9	UGT1A, UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9
20	imipramine32 34 9 18 9	12.9	UGT1A, UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7
21	troglitazone32 42 9 9	11.9	UGT1A3, UGT1A4, UGT1A6, UGT1A9, CYP3A4, CYP2C8
22	morphine32 9 9	10.8	CYP2C8, UGT1A, UGT1A1, UGT1A3, UGT1A4, UGT1A6
23	saquinavir32 9 9	10.8	SLCO1B1, UGT1A, UGT1A1, CYP3A4, CYP2C8, CYP3A5
24	indinavir32 9 9	10.7	UGT1A, UGT1A1, UGT1A3, IGF1, CYP3A4, CYP3A5
25	rifampicin32	8.7	NAT2, UGT1A, UGT1A1, UGT1A6, CYP1A2, CYP3A4
26	androstane32	8.6	SLCO1B1, ABCG2, CYP2C8, CYP3A5, ABCB1, CYP3A4
27	buprenorphine32 9 9	10.6	UGT1A, UGT1A1, UGT1A3, UGT1A9, CYP1A2, CYP3A4
28	phenytoin32 34 9 9	11.6	ABCB1, CYP3A5, CYP2C8, CYP3A4, CD40LG, UGT1A1
29	uridine diphosphate32	8.6	UGT1A9, UGT2B15, TPMT, CYP1A2, CYP3A4, DPYD
30	2-methoxyestradiol32 18	9.5	HIF1A, UGT2B4, UGT1A1, UGT1A3, UGT1A4, UGT1A6
31	acetaminophen32 34 9 18 9	12.5	NAT2, UGT1A, UGT1A1, UGT1A4, UGT1A6, UGT1A7
32	ritonavir32 34 9 9	11.5	CYP3A4, SLCO1B1, UGT1A1, ABCG2, CYP1A2, CYP3A5
33	codeine32 34 9 18 9	12.3	UGT1A9, UGT2B10, UGT2B11, UGT2B15, UGT2B4, CYP1A2
34	clopidogrel32 34 9 18 9	12.3	CD40LG, ABCB1, CYP3A5, SELP, SERPINC1, CYP3A4
35	propofol32 9 9	10.2	SELP, UGT1A, UGT1A1, UGT1A3, UGT1A9, HMOX1
36	losartan32 34 9 9	11.2	CYP2C8, CYP3A5, CYP3A4, CYP1A2, IGF1, UGT1A3
37	diclofenac32 34 9 9	11.1	UGT1A6, UGT1A9, UGT2B15, CYP1A2, CYP3A4, CYP2C8
38	phenobarbital32 9 9	10.0	UGT1A1, HMOX1, CYP1A2, CYP3A4, CYP2C8, CYP3A5
39	sorafenib32 9 9	9.9	CYP3A4, CYP1A2, UGT1A9, CYP2C8, ABCG2, ABCB1
40	estradiol32 9 18 9	10.8	UGT1A, UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7
41	erlotinib32 34 9 9	10.6	VEGFA, KDR, IGF1, CYP1A2, CYP3A4, CYP2C8
42	quercetin32 42 9 18 9	11.3	ABCG2, UGT1A9, CYP2C8, CYP3A4, CYP1A2, UGT1A3
43	irinotecan32 34 9 9	10.2	UGT1A7, UGT1A9, TPMT, CYP3A4, CYP3A5, ABCB1
44	sunitinib32 9 9	9.2	KDR, CYP3A4, CYP3A5, HIF1A, VEGFA, ABCB1
45	estrone32 9 18 9	9.9	UGT2B15, UGT2B4, IGF1, CYP1A2, CYP3A4, CYP2C8
46	testosterone32 9 18 9	8.3	UGT2B10, UGT2B11, UGT2B15, UGT2B4, CD40LG, IGF1
47	tamoxifen32 34 9 9	8.0	ABCB1, ABCG2, G6PD, HIF1A, CYP3A5, CYP2C8
48	retinoic acid32 42 18	6.7	SELP, KDR, UGT1A, UGT1A1, UGT1A3, UGT1A4
49	dexamethasone32 42 34 9 9	8.7	KDR, UGT1A, UGT1A1, CD40LG, IGF1, HMOX1
50	estrogen32	4.5	SELP, SERPINC1, DPYD, NEU1, HIF1A, G6PD

Cellular components related to gilbert syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intracellular membrane-bounded organelle	GO:043231	8.8	G6PD, CYP3A5, CYP3A4, CYP1A2, UGT2B4, UGT1A9
2	endoplasmic reticulum membrane	GO:005789	7.0	UGT1A1, CYP3A5, CYP2C8, CYP3A4, CYP1A2, HMOX1

Biological processes related to gilbert syndrome according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	flavone metabolic process	GO:051552	10.4	UGT1A9, UGT1A7, UGT1A1
2	negative regulation of catalytic activity	GO:043086	10.3	UGT1A1, UGT1A7, UGT1A9
3	xenobiotic glucuronidation	GO:052697	10.3	UGT1A9, UGT1A7, UGT1A3, UGT1A1
4	flavonoid glucuronidation	GO:052696	10.3	UGT1A9, UGT1A7, UGT1A3, UGT1A1
5	retinoic acid metabolic process	GO:042573	10.3	UGT1A9, UGT1A7, UGT1A3, UGT1A1
6	negative regulation of fatty acid metabolic process	GO:045922	10.2	UGT1A7, UGT1A9
7	alkaloid catabolic process	GO:009822	10.1	CYP3A5, CYP3A4
8	metabolic process	GO:008152	10.1	UGT1A3, UGT1A6, UGT1A9, UGT2B4
9	heterocycle metabolic process	GO:046483	10.1	CYP3A4, CYP1A2, UGT1A1
10	drug catabolic process	GO:042737	10.0	CYP3A5, CYP3A4, CYP1A2
11	steroid catabolic process	GO:006706	10.0	CYP1A2, CYP3A4
12	exogenous drug catabolic process	GO:042738	10.0	CYP1A2, CYP3A4, CYP2C8
13	steroid metabolic process	GO:008202	9.9	UGT1A1, UGT2B15, CYP3A4, CYP3A5
14	oxidative demethylation	GO:070989	9.8	CYP3A5, CYP2C8, CYP3A4, CYP1A2
15	porphyrin-containing compound metabolic process	GO:006778	9.7	CYP1A2, HMOX1, UGT1A1
16	oxidation-reduction process	GO:055114	9.7	G6PD, CYP2C8, CYP3A4, CYP1A2
17	drug metabolic process	GO:017144	9.6	CYP2C8, CYP3A4, CYP1A2, UGT1A9, UGT1A7, UGT1A1
18	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061419	9.3	HIF1A, VEGFA
19	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.1	SELP, KDR, IGF1
20	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO:043619	8.7	HMOX1, HIF1A
21	positive regulation of smooth muscle cell proliferation	GO:048661	8.5	HIF1A, HMOX1, IGF1
22	xenobiotic metabolic process	GO:006805	8.2	CNDP2, CYP3A5, CYP2C8, CYP3A4, CYP1A2, TPMT
23	positive regulation of angiogenesis	GO:045766	8.2	HIF1A, HMOX1, KDR, VEGFA
24	small molecule metabolic process	GO:044281	6.6	CYP2C8, CYP3A5, ABCB1, ABCG2, G6PD, DPYD

Molecular functions related to gilbert syndrome according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	xenobiotic-transporting ATPase activity	GO:008559	9.8	ABCB1, ABCG2
2	caffeine oxidase activity	GO:034875	9.8	CYP1A2, CYP3A4, CYP2C8
3	enzyme inhibitor activity	GO:004857	9.8	UGT1A1, UGT1A7, UGT1A9
4	aromatase activity	GO:070330	9.6	CYP3A5, CYP2C8, CYP1A2
5	monooxygenase activity	GO:004497	9.5	CYP3A5, CYP2C8, CYP3A4, CYP1A2
6	retinoic acid binding	GO:001972	9.5	UGT2B4, UGT2B15, UGT1A9, UGT1A7, UGT1A6, UGT1A4
7	glucuronosyltransferase activity	GO:015020	9.1	UGT1A1, UGT2B4, UGT2B15, UGT1A3, UGT1A4, UGT1A6
8	heme binding	GO:020037	8.8	HMOX1, CYP1A2, CYP3A4, CYP2C8, CYP3A5
9	protein heterodimerization activity	GO:046982	8.5	HIF1A, UGT1A9, UGT1A7, UGT1A6, UGT1A4, UGT1A3
10	protein homodimerization activity	GO:042803	8.1	HMOX1, ABCG2, G6PD, DPYD, UGT1A9, UGT1A7
11	enzyme binding	GO:019899	7.9	HIF1A, CYP3A4, CYP1A2, HMOX1, UGT1A9, UGT1A7