MCID: GLB001
MIFTS: 59

Gilbert Syndrome malady

Metabolic, Liver, Genetic categories

Summaries for Gilbert Syndrome

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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Genetics Home Reference:21 Gilbert syndrome is a relatively mild condition characterized by periods of elevated levels of a toxic substance called bilirubin in the blood (hyperbilirubinemia). Bilirubin, which has an orange-yellow tint, is produced when red blood cells are broken down. This substance is removed from the body only after it undergoes a chemical reaction in the liver, which converts the toxic form of bilirubin (unconjugated bilirubin) to a nontoxic form called conjugated bilirubin. People with Gilbert syndrome have a buildup of unconjugated bilirubin in their blood (unconjugated hyperbilirubinemia). In affected individuals, bilirubin levels fluctuate and very rarely increase to levels that cause jaundice, which is yellowing of the skin and whites of the eyes.

MalaCards: Gilbert Syndrome, also known as gilbert's syndrome, is related to kernicterus and hereditary spherocytosis. An important gene associated with Gilbert Syndrome is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Caffeine Pathway, Pharmacokinetics. The compounds Ezogabine and sn38 glucuronide have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and breast.

Disease Ontology:8 A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity.

NIH Rare Diseases:43 Gilbert syndrome is a common, mild liver disorder in which the liver doesn't properly process bilirubin, a substance produced by the breakdown of red blood cells. gilbert syndrome typically doesn't require treatment or pose serious complications. in fact, gilbert syndrome is usually not considered a disease because of its benign nature. many individuals find out they have the disorder by accident, when they have a blood test that shows elevated bilirubin levels. more males than females have been diagnosed with gilbert syndrome. this condition is caused by mutations in the ugt1a1 gene and is inherited in an autosomal recessive pattern. last updated: 5/2/2011

Wikipedia:64 Gilbert\'s syndrome (/ʒiːlˈbɛər/ zheel-BAIR), often shortened to GS, also called... more...

Description from OMIM:47 143500

Aliases & Classifications for Gilbert Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 47OMIM, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Metabolic, Liver


Aliases & Descriptions:

gilbert syndrome 8 43 21 10 47
gilbert's syndrome 8 20 22 21
gilbert's disease 8 43 21
gilbert disease 21 61
constitutional hyperbilirubinemia 8
unconjugated benign bilirubinemia 21
constitutional liver dysfunction 21
hereditary nonhemolytic jaundice 8
familial nonhemolytic jaundice 21
hyperbilirubinemia arias type 43
gilbert-meulengracht syndrome 8
gilbert-lereboullet syndrome 21
hyperbilirubinemia type 1 43
meulengracht syndrome 21
hyperbilirubinemia 1 21
cholemia, familial 43
gilberts syndrome 45


External Ids:

Disease Ontology8 DOID:2739
OMIM47 143500
NCIt40 C84729
MeSH35 D005878
ICD1025 E80.4

Related Diseases for Gilbert Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gilbert Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1kernicterus30.7UGT1A1, UGT1A7, UGT1A6, UGT1A4, UGT1A9, G6PD
2hereditary spherocytosis30.4G6PD, UGT1A1
3cholelithiasis30.2UGT1A1, UGT2B4, UGT1A6
4crigler-najjar syndrome30.0UGT1A1, UGT1A4
5deficiency anemia30.0TPMT, G6PD
6beta thalassemia30.0G6PD, UGT1A1
7congenital nonhemolytic jaundice10.4
8n syndrome10.4
9hypertrophic pyloric stenosis10.2
103-m syndrome10.2
11paraplegia - intellectual deficit - hyperkeratosis10.2
12cystic fibrosis10.0
13hepatitis c10.0
14gaucher's disease10.0
15hemochromatosis10.0
16choledocholithiasis10.0
17hepatitis d10.0
18ulcerative colitis10.0
19adult syndrome10.0
20kawasaki disease10.0
21aplastic anemia10.0
22thalassemia10.0
23vascular cancer10.0
24young syndrome10.0
25familial adenomatous polyposis10.0NAT2
26hepatitis10.0UGT1A1, NAT2
275-fluorouracil toxicity10.0DPYD
28crigler najjar syndrome, type 210.0UGT1A1, UGT1A4
29glucosephosphate dehydrogenase deficiency10.0UGT1A1, G6PD
30diarrhea10.0UGT1A1, UGT1A6, DPYD
31alpha thalassemia10.0UGT1A1, G6PD
32bilirubin metabolic disorder10.0G6PD, UGT1A7, UGT1A, UGT1A1
33neonatal jaundice10.0G6PD, UGT1A1
34autoimmune hepatitis10.0TPMT, UGT1A9, UGT1A1
35neutropenia10.0TPMT, DPYD, UGT1A1, UGT1A6
36pancreatitis10.0UGT1A7, TPMT
37galactosemia10.0G6PD, TPMT, UGT1A1, UGT2B4
38leukopenia10.0UGT1A1, DPYD, TPMT
39colon cancer10.0NAT2, DPYD, UGT1A1, UGT1A
40breast cancer10.0DPYD, UGT1A9, UGT1A, G6PD, UGT1A1, NAT2
41hepatocellular carcinoma10.0UGT1A9, NAT2, DPYD, UGT1A7, UGT1A, UGT1A1
42colorectal cancer10.0UGT1A7, UGT1A1, UGT1A6, TPMT, UGT1A9, DPYD
43lung cancer10.0UGT1A7, NAT2, UGT1A1, UGT1A, DPYD

Graphical network of the top 20 diseases related to Gilbert Syndrome:



Diseases related to gilbert syndrome

Clinical Features for Gilbert Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

143500

Clinical synopsis from OMIM:

143500

Drugs & Therapeutics for Gilbert Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gilbert Syndrome

Drug clinical trials:

Search ClinicalTrials for Gilbert Syndrome

Search NIH Clinical Center for Gilbert Syndrome

Search CenterWatch for Gilbert Syndrome

Genetic Tests for Gilbert Syndrome

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Gilbert Syndrome:

id Genetic test Affiliating Genes
1 Gilbert Syndrome20 UGT1A1
2 Gilbert's Syndrome22

Anatomical Context for Gilbert Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gilbert Syndrome:

33
Heart, Liver, Breast, Skin, T cells, B cells, Endothelial

Animal Models for Gilbert Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Gilbert Syndrome

Sources:
51PubMed
See all sources

Articles related to Gilbert Syndrome:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
A Case of hereditary spherocytosis coexisting with Gilbert's syndrome. (23575236)
2013
2
Coexistence of Gilbert syndrome with hereditary haemolytic anaemias. (22554963)
2012
3
Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects. (22325916)
2012
4
Gilbert syndrome: the UGT1A1*28 promoter polymorphism as a biomarker of multifactorial diseases and drug metabolism. (22448797)
2012
5
Diagnosis and treatment difficulties in 18-year-old male patient with hereditary hemochromatosis, chronic hepatitis B, Gilbert syndrome and ulcerative colitis. (21633730)
2011
6
Is Gilbert syndrome a new risk factor for breast cancer? (21636218)
2011
7
Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert's syndrome. (21388537)
2011
8
A case of concomitant Gilbert's syndrome and hereditary spherocytosis. (20924216)
2010
9
Pegvisomant-induced liver injury is related to the UGT1A1*28 polymorphism of Gilbert's syndrome. (20207827)
2010
10
Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome). (20955959)
2010
11
Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome. (20529348)
2010
12
Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population. (19309288)
2009
13
Gilbert's syndrome and antiviral therapy of hepatitis C. (19841506)
2009
14
Pegvisomant-induced cholestatic hepatitis with jaundice in a patient with Gilbert's syndrome. (19258431)
2009
15
Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin. (18343383)
2008
16
''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. (17825497)
2007
17
Molecular pathogenesis of Gilbert's syndrome: decreased TATA-binding protein binding affinity of UGT1A1 gene promoter. (17496722)
2007
18
Gilbert syndrome in the newborn. (17990369)
2007
19
Gilbert's syndrome: High frequency of the (TA)7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene. (16610035)
2006
20
Linkage between A(TA)7TAA and -3279T>G mutations in UGT1A1 is not essential for pathogenesis of Gilbert syndrome. (17105600)
2006
21
Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia: genetic screening is unnecessary. (16652295)
2006
22
The polymorphism c.-3279T>G in the phenobarbital-responsive enhancer module of the bilirubin UDP-glucuronosyltransferase gene is associated with Gilbert syndrome. (16244305)
2005
23
Dual hereditary jaundice: simultaneous occurrence of mutations causing Gilbert's and Dubin-Johnson syndrome. (16012956)
2005
24
What is Gilbert's syndrome? Lesson from genetic polymorphisms of UGT1A1 in Gilbert's syndrome from Asia. (15304109)
2004
25
Two linked polymorphic mutations (A(TA)7TAA and T-3279G) of UGT1A1 as the principal cause of Gilbert syndrome. (15378351)
2004
26
Co-occurrence of three different mutations in the bilirubin UDP-glucuronosyltransferase gene in a Chinese family with Crigler-Najjar syndrome type I and Gilbert's syndrome. (14616765)
2003
27
Predicting the risk of sporadic elevated bilirubin levels and diagnosing Gilbert's syndrome by genotyping UGT1A1*28 promoter polymorphism. (12078936)
2002
28
Chronic hemolytic anemia associated with glucose 6-phosphate dehydrogenase (Guadalajara)1 159 C --> T (387 Arg --> Cys) deficiency associated with Gilbert syndrome in a Turkish patient. (11787865)
2002
29
Cholelithiasis and Gilbert's syndrome in homozygous beta-thalassaemia. (11843828)
2001
30
Gilbert's syndrome is not associated with HELLP syndrome. (11563452)
2001
31
Variation in UGT1A1 activity in Gilbert's syndrome. (11394668)
2001
32
Correlation of mutational analysis to clinical features in Taiwanese patients with Gilbert's syndrome. (11316168)
2001
33
Hyperbilirubinaemia, glucose-6-phosphate dehydrogenase deficiency and Gilbert syndrome. (11277384)
2001
34
Genetic interactions in the pathogenesis of neonatal hyperbilirubinemia: Gilbert's Syndrome and glucose-6-phosphate dehydrogenase deficiency. (11803413)
2001
35
Unusual early presentation of Gilbert syndrome in pediatric recipients of liver transplantation. (10997365)
2000
36
Gilbert's syndrome and jaundice in glucose-6-phosphate dehydrogenase deficient neonates. (11114816)
2000
37
Gilbert syndrome: analysis of the promoter region of the uridine diphosphate-glucuronosyltransferase 1 gene in the Greek population. (11079211)
2000
38
Melting temperature assay for a UGT1A gene variant in Gilbert syndrome. (10702534)
2000
39
Distribution of the A(TA)7TAA genotype associated with Gilbert syndrome in the Spanish population]. (11141380)
2000
40
Hyperbilirubinemia, glucose-6-phosphate-dehydrogenase deficiency and Gilbert's syndrome. (10541948)
1999
41
Contribution of the TATA-box genotype (Gilbert syndrome) to serum bilirubin concentrations in the Italian population. (10352000)
1999
42
Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler-Najjar syndrome type II. (9630669)
1998
43
Gilbert syndrome caused by a homozygous missense mutation (Tyr486Asp) of bilirubin UDP-glucuronosyltransferase gene. (9627603)
1998
44
Benign congenital jaundice (hyperbilirubinemia): a case of Gilbert syndrome. (9592443)
1998
45
Hyperbilirubinaemia in heterozygous beta-thalassaemia is related to co-inherited Gilbert's syndrome. (9375768)
1997
46
Gilbert's syndrome co-existing with and masking hereditary spherocytosis. (9236515)
1997
47
Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia. (9342374)
1997
48
Kernicterus in an adult who is heterozygous for Crigler-Najjar syndrome and homozygous for Gilbert-type genetic defect. (9178703)
1997
49
Gilbert syndrome. (8716954)
1996
50
Gilbert syndrome and factor-VII deficiency. (4194152)
1970

Genetic Variations for Gilbert Syndrome

Expression for genes affiliated with Gilbert Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gilbert Syndrome

Search GEO for disease gene expression data for Gilbert Syndrome.

Pathways for genes affiliated with Gilbert Syndrome

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Gilbert Syndrome according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3UGT1A1, CYP2C8
210.2NAT2, CYP2C8
310.2UGT1A4, UGT1A9, NAT2
4
Hide members
10.1UGT2B10, UGT1A4, UGT1A9
5
Hide members
10.1UGT1A9, UGT1A1, CYP2C8
6
Hide members
10.1UGT1A6, CYP2C8, UGT1A9
710.0UGT1A6, UGT1A9, UGT1A4, UGT1A3
8
Hide members
10.0UGT1A9, UGT1A3, CYP2C8, UGT1A1
9
Hide members
10.0UGT1A3, UGT1A9, UGT1A4, UGT1A1, UGT1A6
10
Hide members
9.9UGT1A1, CYP2C8, UGT1A6, UGT1A4, UGT1A9
11
Acetaminophen metabolism
Hide members
9.9UGT1A1, UGT1A4, UGT1A6, NAT2, UGT1A3, UGT1A9
12
Hide members
9.7UGT1A9, UGT1A6, UGT1A4, UGT1A1, UGT1A7, UGT1A3
13
Hide members
9.4UGT1A9, UGT1A4, UGT2B4, UGT1A1, UGT2B28, UGT1A3
14
Hide members
8.9UGT2A3, UGT1A7, UGT2B10, UGT1A3, UGT2A1, UGT2B11
15
Hide members
8.8CYP2C8, UGT1A9, UGT2B11, UGT2A1, UGT1A3, UGT2B10
16
Hide members
8.7G6PD, UGT1A1, UGT1A9, UGT1A4, UGT2B4, UGT1A6
17
Hide members
8.7UGT2B11, UGT2A1, UGT1A3, UGT2B10, UGT1A7, UGT2A3

Compounds for genes affiliated with Gilbert Syndrome

Sources:
11DrugBank, 45Novoseek, 60Tocris Bioscience, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Gilbert Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1Ezogabine 1110.3UGT1A1, UGT1A3, NAT2, UGT1A4, UGT1A9
2sn38 glucuronide4510.3UGT1A1, UGT1A7, UGT1A, UGT1A9
3lamotrigine45 1111.2UGT1A, UGT1A4, UGT1A6, UGT1A1, UGT1A3
41-naphthol4510.2UGT2B4, UGT1A1, UGT1A9, UGT1A6, UGT1A
5phip4510.2UGT1A1, UGT1A4, UGT1A, UGT1A9, NAT2
6benzidine4510.2UGT1A6, UGT1A, UGT1A9, UGT1A4, UGT1A1, NAT2
74-methylumbelliferone4510.2UGT1A1, UGT1A9, UGT1A, UGT1A6
8n-hydroxy phip4510.2UGT1A7, UGT1A, UGT1A9, UGT1A4, UGT1A6, UGT1A1
9sn 3845 6011.2UGT1A1, UGT1A7, UGT1A, DPYD, UGT1A9
10phenol45 2411.2G6PD, NAT2, UGT1A1, UGT1A6, UGT1A9, UGT1A
11flurbiprofen45 29 50 1113.2UGT1A, UGT1A9, UGT2B4, UGT1A1, UGT1A3
12buprenorphine45 29 1112.1UGT1A9, UGT1A1, UGT1A3, CYP2C8, UGT1A
13ethyl glucuronide45 2411.1UGT1A1, UGT1A7, UGT1A3, UGT1A6, UGT2B4, UGT1A9
14benzo(a)pyrene4510.1UGT1A1, UGT1A6, UGT1A9, UGT1A7, NAT2, UGT1A
15udp glucuronic acid4510.1UGT1A6, UGT2B4, UGT1A1, UGT1A
16imipramine45 50 29 11 2414.1UGT1A9, UGT1A7, UGT1A4, UGT1A6, UGT1A, UGT1A1
17trifluoperazine45 29 1112.1UGT1A1, UGT1A6, UGT1A9, UGT1A4, UGT1A
18propofol45 50 1112.1UGT1A4, UGT1A, UGT1A9, UGT1A3, UGT1A6, UGT1A1
19irinotecan45 50 1112.1DPYD, UGT1A9, UGT1A6, UGT1A1, UGT1A7, TPMT
20p-nitrophenol45 1111.1UGT1A, UGT1A4, UGT2B4, UGT1A9, UGT1A6, UGT1A1
21amine4510.0UGT1A3, UGT1A, UGT1A1, UGT1A7, NAT2, UGT1A4
22diclofenac45 29 50 1113.0CYP2C8, UGT1A3, UGT1A1, UGT1A4, UGT1A9, UGT1A
23sulfamethoxazole45 50 1112.0G6PD, UGT1A9, NAT2, CYP2C8
24cotinine45 2411.0NAT2, UGT1A3, UGT1A7, UGT1A1, UGT1A6, UGT1A4
25glucuronide4510.0UGT1A, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1
26troglitazone45 29 60 1113.0UGT1A9, CYP2C8, UGT1A3, UGT1A1, UGT1A6, UGT1A4
27mycophenolate mofetil45 50 1112.0UGT1A, UGT1A9, TPMT, CYP2C8, UGT1A1
28valproic acid45 50 11 2413.0UGT1A7, UGT1A1, UGT1A6, UGT1A, UGT1A3, UGT1A9
29epoxide459.9UGT1A, NAT2, CYP2C8, UGT1A7, UGT1A1
30morphine45 50 29 1112.9UGT1A3, CYP2C8, UGT1A6, UGT1A4, UGT1A9, UGT1A
31uridine45 11 2411.9UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT1A7
32uridine diphosphate459.9UGT1A1, UGT1A7, UGT1A3, DPYD, NAT2, TPMT
33nicotine45 50 29 1112.8CYP2C8, UGT1A, UGT2B10, UGT1A7, UGT1A1, UGT1A6
34rifampicin45 29 6011.8UGT1A1, NAT2, CYP2C8, UGT1A6, UGT1A
35acetaminophen45 2 50 11 2413.8UGT2B4, NAT2, G6PD, UGT1A, UGT1A9, UGT1A4
36tamoxifen45 50 29 1112.8UGT1A4, UGT2B4, UGT1A6, UGT1A1, CYP2C8, UGT1A3
37ibuprofen45 29 50 11 2413.6CYP2C8, UGT1A3, UGT1A1, UGT2B4, UGT1A9
38etiocholanolone45 2410.5UGT1A7, UGT2B10, UGT1A3, UGT2A1, UGT2B11, UGT1A9
393-alpha-androstanediol glucuronide45 2410.5UGT1A6, UGT1A1, UGT2B28, UGT2A3, UGT1A7, UGT2B10
40estriol29 11 2411.5UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT2B28, UGT2A3
41androsterone glucuronide45 2410.5UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
422-methoxyestradiol45 60 2411.5UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
43(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)249.5UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
44bilirubin diglucuronide45 2410.5UGT2B10, UGT1A3, UGT2A1, UGT2B11, UGT1A7, UGT2A3
45aldosterone 18-glucuronide45 2410.5UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
46codeine45 50 29 11 2413.3UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2B28
47estrone45 29 11 2412.2UGT1A, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1
48estradiol45 11 2411.2UGT1A, UGT2B10, CYP2C8, UGT2B11, UGT1A3, UGT1A9
49retinoic acid45 2410.2UGT1A, UGT2A1, UGT1A3, UGT1A7, UGT2A3, UGT2B28
50testosterone45 60 11 2412.1UGT1A, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1

GO Terms for genes affiliated with Gilbert Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Gilbert Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:04323110.0UGT1A6, UGT2B4, UGT1A9, G6PD
2endoplasmic reticulum membraneGO:0057899.1CYP2C8, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1
3integral to membraneGO:0160218.5UGT3A2, UGT1A6, UGT2B4, UGT1A4, UGT1A9, UGT2B28

Biological processes related to Gilbert Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1xenobiotic glucuronidationGO:05269710.3UGT1A9, UGT1A1, UGT1A7, UGT1A3
2flavone metabolic processGO:05155210.3UGT1A7, UGT1A1, UGT1A9
3flavonoid glucuronidationGO:05269610.3UGT1A9, UGT1A1, UGT1A7, UGT1A3
4estrogen metabolic processGO:00821010.2UGT2B11, UGT1A1
5retinoic acid metabolic processGO:04257310.2UGT1A9, UGT1A1, UGT1A7, UGT1A3
6drug metabolic processGO:01714410.2UGT1A9, UGT1A1, UGT1A7, CYP2C8
7negative regulation of catalytic activityGO:04308610.1UGT1A9, UGT1A1, UGT1A7
8cellular glucuronidationGO:05269510.0UGT1A4, UGT2B4, UGT1A6, UGT1A1, UGT2A3, UGT2A1
9negative regulation of fatty acid metabolic processGO:04592210.0UGT1A7, UGT1A9
10metabolic processGO:00815210.0UGT1A9, UGT2B4, UGT1A6, UGT2B28, UGT1A3, UGT2A1
11xenobiotic metabolic processGO:0068059.6TPMT, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT1A1
12small molecule metabolic processGO:0442819.5G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A1, DPYD

Molecular functions related to Gilbert Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1UDP-glycosyltransferase activityGO:00819410.2UGT1A3, UGT3A2
2enzyme inhibitor activityGO:0048579.9UGT1A7, UGT1A1, UGT1A9
3enzyme bindingGO:0198999.9UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A7, UGT1A3
4retinoic acid bindingGO:0019729.8UGT1A3, UGT1A7, UGT1A1, UGT1A6, UGT2B4, UGT1A4
5protein heterodimerization activityGO:0469829.8UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A7, UGT1A3
6protein homodimerization activityGO:0428039.7G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A7
7glucuronosyltransferase activityGO:0150209.1UGT2B11, UGT1A9, UGT1A4, UGT2B4, UGT1A6, UGT2A1

Products for genes affiliated with Gilbert Syndrome

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  • Lysates
  • Antibodies

Sources for Gilbert Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet