TD
MCID: GLL008
MIFTS: 73

Gilles De La Tourette Syndrome (TD) malady

Neuronal diseases category

Summaries for Gilles De La Tourette Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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NIH Rare Diseases:42 Tourette syndrome is a disorder of the nervous system that causes a person to make repeated and uncontrolled (involuntary) movements and sounds (vocalizations) called tics. tourette syndrome is named for georges gilles de la tourette, who first described this disorder in 1885. there is strong evidence that tourette syndrome is passed down through families, although the gene has not yet been found. the syndrome may be linked to problems in certain areas of the brain, and the chemical substances (dopamine, serotonin, and norepinephrine) that help nerve cells talk to one another. tourette syndrome can be either severe or mild. it is estimated that about 1% of the population has tourette syndrome. many people with very mild tics may not be aware of them and never seek medical help.   tourette syndrome is four times as likely to occur in boys as in girls.  although tourette syndrome can be a chronic condition with symptoms lasting a lifetime, most people with the condition experience their worst symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood. last updated: 7/14/2011

MalaCards: Gilles De La Tourette Syndrome, also known as tourette syndrome, is related to obsessive-compulsive disorder and hypertension. An important gene associated with Gilles De La Tourette Syndrome is SLITRK1 (SLIT and NTRK-like family, member 1), and among its related pathways are Dopamine receptors and Monoamine GPCRs. The drugs clonidine and haloperidol and the compounds Carphenazine and Thiethylperazine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.

Genetics Home Reference:21 Tourette syndrome is a complex disorder characterized by repetitive, sudden, and involuntary movements or noises called tics. Tics usually appear in childhood, and their severity varies over time. In most cases, tics become milder and less frequent in late adolescence and adulthood.

MedlinePlus:33 If you have tourette syndrome, you make unusual movements or sounds, called tics. you have little or no control over them. common tics are throat-clearing and blinking. you may repeat words, spin, or, rarely, blurt out swear words. tourette syndrome is a disorder of the nervous system. it often occurs with other problems, such as attention deficit hyperactivity disorder (adhd) obsessive-compulsive disorder (ocd) anxiety depression the cause of tourette syndrome is unknown. it is more common in boys than girls. the tics usually start in childhood and may be worst in the early teens. many people eventually outgrow them. no treatment is needed unless the tics interfere with everyday life. excitement or worry can make tics worse. calm, focused activities may make them better. medicines and talk therapy may also help. nih: national institute of neurological disorders and stroke

NINDS:43 Tourette syndrome (TS) is a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. The first symptoms of TS are almost always noticed in childhood. Some of the more common tics include eye blinking and other vision irregularities, facial grimacing, shoulder shrugging, and head or shoulder jerking. Perhaps the most dramatic and disabling tics are those that result in self-harm such as punching oneself in the face, or vocal tics including coprolalia (uttering swear words) or echolalia (repeating the words or phrases of others). Many with TS experience additional neurobehavioral problems including inattention, hyperactivity and impulsivity, and obsessive-compulsive symptoms such as intrusive thoughts/worries and repetitive behaviors.

Wikipedia:63 Tourette syndrome (also called Tourette\'s syndrome, Tourette\'s disorder, Gilles de la Tourette... more...

Description from OMIM:46 137580

GeneReviews summary for tourette

Aliases & Classifications for Gilles De La Tourette Syndrome

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8Disease Ontology, 9diseasecard, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

gilles de la tourette syndrome 8 19 21 10 60
tourette syndrome 8 9 19 42 21 43 46 44 33
tourette's syndrome 42 20 22
tourette disorder 19 42 21
gilles de la tourette's syndrome 42 21
chronic motor and vocal tic disorder 21
thanatophoric dysplasia, type i 60
motor-verbal tic disorder 8
tourette's disease 21
guinon's disease 8
psychogenic tics 8
maladie de tics 19
gts 21
ts 21
td 21


External Ids:

Disease Ontology8 DOID:11119
ICD9CM27 307.23
MeSH34 D005879
NCIt39 C35078
OMIM46 137580
ICD1025 F95.1

Related Diseases for Gilles De La Tourette Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Gilles De La Tourette Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 695)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive disorder31.3DRD2, DRD4, TTF2, SGCE
2hypertension30.8DBH
3obesity30.7ADRA2A, TTF2, DRD4, DRD2, ISL1
4attention deficit hyperactivity disorder30.7DRD2, DRD4, DRD5, DBH, TTF2, ADRA2A
5schizophrenia30.6DRD2, DRD4, DRD5, DBH, TTF2, ADRA2A
6substance abuse30.5DRD4, DRD2
7pathological gambling30.3DRD2, DRD4
8migraine30.3DBH, DRD5, DRD4, DRD2
9alcohol dependence30.2DRD2, DRD4
10myoclonus-dystonia29.9DRD2, SGCE
11alcohol abuse29.9DRD2
12bipolar disorder29.9DBH, DRD5, DRD4, DRD2
13conduct disorder29.9DRD2, DRD4, DRD5, DBH, TTF2
14panic disorder29.8DRD4, TTF2
15wilson disease29.8SLITRK1, DRD2
16heroin dependence29.5DRD4, DRD2
17mood disorder29.5DRD2, DRD4, DBH, ADRA2A
18tic disorder10.8
19adult syndrome10.8
20thalassemia10.7
21breast cancer10.7
22colorectal cancer10.6
23coronary artery disease10.6
24chronic tic disorder10.6
25image syndrome10.6
26arthritis10.5
27myocardial infarction10.5
28hepatitis10.5
29lung cancer10.5
30alpha thalassemia10.5
31rheumatoid arthritis10.5
32beta thalassemia10.4
33parkinson's disease10.4
34rett syndrome10.4
35major depressive disorder10.4
36huntington's disease10.4
37cerebritis10.4
38pain disorder10.4
39neuronitis10.4
40echolalia10.4
41cervicitis10.4
42epilepsy syndrome10.4
43familial dystonia10.4
44impulse control disorder10.4
45movement disease10.4
46neuropathy10.4
47smith magenis syndrome10.4
48charge syndrome10.4
49townes-brocks syndrome10.4
50diabetes mellitus10.4

Graphical network of the top 20 diseases related to Gilles De La Tourette Syndrome:



Diseases related to gilles de la tourette syndrome

Clinical Features for Gilles De La Tourette Syndrome

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46OMIM
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Clinical features from OMIM:

137580

Clinical synopsis from OMIM:

137580

Drugs & Therapeutics for Gilles De La Tourette Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gilles De La Tourette Syndrome

Drug clinical trials:

Search ClinicalTrials for Gilles De La Tourette Syndrome

Search NIH Clinical Center for Gilles De La Tourette Syndrome

Search CenterWatch for Gilles De La Tourette Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gilles De La Tourette Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Gilles De La Tourette Syndrome:

id Genetic test Affiliating Genes
1 Tourette Syndrome20 22 SLITRK1

Anatomical Context for Gilles De La Tourette Syndrome

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32MalaCards
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MalaCards organs/tissues related to Gilles De La Tourette Syndrome:

32
Brain, Eye, Cortex, Globus pallidus, Thalamus

Animal Models for Gilles De La Tourette Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gilles De La Tourette Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.3DRD4, IER3, TBXA2R, DBH, ROBO3, ROBO4
2MP:00036319.1TDO2, ISL1, DRD2, DRD4, DRD5, CBLN2
3MP:00053869.1CBLN2, DRD4, DRD2, ISL1, DBH, CNTNAP2
4MP:00053859.1ISL1, DRD2, DRD5, IER3, TBXA2R, DBH

Publications for Gilles De La Tourette Syndrome

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50PubMed
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Articles related to Gilles De La Tourette Syndrome:

(show top 50)    (show all 303)
idTitleAuthorsYear
1
The functional anatomy of Gilles de la Tourette syndrome. (23237884)
2013
2
Echoes from childhood--imitation in Gilles de la Tourette Syndrome. (22278950)
2012
3
The Gilles de la Tourette Syndrome-Quality of Life Scale for children and adolescents (C&A-GTS-QOL): Development and validation of the Italian version. (24036964)
2012
4
Functional immaturity of cortico-basal ganglia networks in Gilles de la Tourette syndrome. (22434213)
2012
5
Are premonitory urges a prerequisite of tic inhibition in Gilles de la Tourette syndrome? (22842713)
2012
6
Delayed experience of volition in Gilles de la Tourette syndrome. (21212106)
2011
7
Gilles de la Tourette syndrome: the complexities of phenotype and treatment. (21378617)
2011
8
"Trousseau's disease:" a description of the Gilles de la Tourette syndrome 12 years before 1885. (20672342)
2010
9
Complementary and alternative medicine use in Gilles de la Tourette syndrome. (19705358)
2009
10
Famous people with Gilles de la Tourette syndrome? (19913652)
2009
11
The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes. (18940378)
2008
12
Catatonic signs in Gilles de la Tourette syndrome. (18327021)
2008
13
Aripiprazole: a treatment for severe coprolalia in "refractory" Gilles de la Tourette syndrome. (18067182)
2008
14
Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome. (18772048)
2008
15
Vagus nerve stimulation in a patient with Gilles de la Tourette syndrome and major depression. (18484555)
2008
16
Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implications. (18359008)
2008
17
Analysis of the dopamine beta hydroxylase gene in Gilles de la Tourette syndrome. (16838359)
2006
18
Perceptual-motor skill learning in Gilles de la Tourette syndrome. Evidence for multiple procedural learning and memory systems. (15989936)
2005
19
Serotonin receptor genes HTR3A and HTR3B are not involved in Gilles de la Tourette syndrome. (16314763)
2005
20
Gilles de la Tourette syndrome: response to electroconvulsive therapy. (16301887)
2005
21
Efficient internal pallidal stimulation in Gilles de la Tourette syndrome: a case report. (16037913)
2005
22
Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility region. (15303240)
2004
23
An update on the genetics of Gilles de la Tourette syndrome. (12842226)
2003
24
Candidate region for Gilles de la Tourette syndrome at 7q31. (11424142)
2001
25
Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus. (10073521)
1999
26
The prevalence of Gilles de la Tourette syndrome in children and adolescents with autism: a large scale study. (10576307)
1999
27
Event-related brain potentials show changed attentional mechanisms in Gilles de la Tourette Syndrome. (24283908)
1997
28
Rates for tic disorders and obsessive compulsive symptomatology in families of children and adolescents with Gilles de la Tourette syndrome. (9368194)
1997
29
Gilles de la Tourette syndrome. (8180905)
1994
30
Elevated frontal cerebral blood flow in Gilles de la Tourette syndrome: a 99Tcm-HMPAO SPECT study. (1484907)
1992
31
Anomalous kinetic visual fields found in family members of patients with a confirmed diagnosis of Gilles de la Tourette syndrome. (1749602)
1991
32
Gilles de la Tourette syndrome: onset in old age. (2005343)
1991
33
Abnormalities of the blink reflex in Gilles de la Tourette syndrome. (2769283)
1989
34
Gilles de la Tourette syndrome: EEG and mapping. (2608809)
1989
35
Pain in Gilles de la Tourette syndrome and related tic disorders. (2804807)
1989
36
Oculomotor control in Gilles de la Tourette syndrome. (3216209)
1988
37
Structural and functional studies of Gilles de la Tourette syndrome. (2881340)
1986
38
Gilles de la Tourette syndrome and the neurological basis of obsessions and compulsions. (3862431)
1985
39
A clinical study of Gilles de la Tourette syndrome in the United Kingdom. (6582230)
1984
40
Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission. (6587775)
1984
41
Treatment approaches in Gilles de la Tourette syndrome. (6578865)
1983
42
Increased body movements during sleep in Gilles de la Tourette syndrome. (6942662)
1981
43
Familial aspects of Gilles de la Tourette syndrome. (6934700)
1981
44
Red-cell choline and Gilles de la Tourette syndrome. (288985)
1979
45
Significance of genetic factors in Gilles de la Tourette syndrome: a review. (281939)
1978
46
Comparison of lithium and haloperidol therapy in Gilles de la Tourette syndrome. (270894)
1977
47
Comparison of pimozide with haloperidol in Gilles de la Tourette syndrome. (63706)
1977
48
Letter: Speech disorder, partial syndrome of Gilles de la Tourette, and drug therapy. (1097015)
1975
49
A behavioral treatment program for the Gilles de la Tourette syndrome. (4529188)
1974
50
Gilles de la Tourette Syndrome. (4527815)
1974

Genetic Variations for Gilles De La Tourette Syndrome

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Expression for genes affiliated with Gilles De La Tourette Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gilles De La Tourette Syndrome

Search GEO for disease gene expression data for Gilles De La Tourette Syndrome.

Pathways for genes affiliated with Gilles De La Tourette Syndrome

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1DRD5, DRD4, DRD2
2
Hide members
10.0ADRA2A, DRD5, DRD4, DRD2
3
Hide members
10.0DRD5, DRD4, DRD2, HTR3B
4
Hide members
9.9DRD2, DRD4, DRD5, TBXA2R, ADRA2A

Compounds for genes affiliated with Gilles De La Tourette Syndrome

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11DrugBank, 44Novoseek, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1Carphenazine1110.6DRD2, DRD5
2Thiethylperazine1110.6DRD2, DRD4
3zuclopenthixol44 49 1112.6DRD2, DRD5, ADRA2A
4(+)-sulpiride2810.6DRD2, DRD4
5(+)-butaclamol28 4411.6DRD2, DRD4, DRD5
6(-)-sulpiride2810.5DRD2, DRD4
7melperone4410.5DRD2, DRD4
8cis flupentixol2810.5DRD2, DRD5
9piribedil28 4411.5DRD2, DRD4, ADRA2A
10rotigotine44 28 1112.5DRD5, DRD4, DRD2
11eticlopride28 4411.5DRD2, DRD4
12fluphenazine28 44 1112.5DRD5, DRD4, DRD2
13terguride28 4411.5ADRA2A, DRD4, DRD2
14spiperone28 4411.5DRD2, DRD4, DRD5
15paliperidone44 1111.5ADRA2A, DRD4, DRD2
16asenapine28 1111.5ADRA2A, DRD4, DRD2
17maoa4410.5DBH, DRD4, DRD2
18methylphenidate44 49 1112.5DRD2, DRD4, DRD5, ADRA2A
19ropinirole44 1111.5DRD2, DRD4, DRD5, ADRA2A
20alpha-methyl-p-tyrosine4410.5DBH, DRD2
21lisuride28 44 1112.5ADRA2A, DRD5, DRD4, DRD2
22pergolide28 44 1112.5DRD2, DRD4, DRD5, ADRA2A
23Methotrimeprazine1110.5DRD2, DRD4, DRD5, ADRA2A
24pramipexole44 49 28 1113.5DRD2, DRD4, DRD5, ADRA2A
25cabergoline28 44 1112.5DRD2, DRD4, DRD5, ADRA2A
26aripiprazole28 49 44 11 2414.5ADRA2A, DRD5, DRD4, DRD2
27ziprasidone49 28 44 1113.5DRD2, DRD4, DRD5, ADRA2A
28apomorphine44 28 1112.5ADRA2A, DRD5, DRD4, DRD2
29quetiapine44 49 28 11 2414.4ADRA2A, DRD5, DRD4, DRD2
30bromocriptine28 44 1112.4DRD2, DRD4, DRD5, ADRA2A
31chlorpromazine44 28 49 1113.4DRD2, DRD4, DRD5, ADRA2A
32nemonapride49 44 2812.4DRD4, DRD2
33olanzapine49 44 28 11 2414.4DRD2, DRD4, DRD5, ADRA2A
34risperidone28 44 49 59 11 2415.4DRD2, DRD4, ADRA2A
35catecholamine4410.4DRD4, DRD5, DBH, ADRA2A
36clozapine44 28 49 1113.4DRD2, DRD4, DRD5, ADRA2A
37levodopa44 1111.4DRD2, DRD4, DRD5, DBH
38sch 233904410.4DRD4, DRD2
39methamphetamine44 49 1112.4DRD2, DRD4, ADRA2A
40Lurasidone1110.4ADRA2A, DRD2
416-hydroxydopamine4410.3DBH, DRD4, DRD2
42remoxipride44 1111.3DRD2, DRD4
43norepinephrine44 11 2412.3DRD2, DRD4, DRD5, DBH, ADRA2A
44nicotine44 49 28 1113.3TTF2, DBH, DRD4, DRD2
45loxapine28 44 1112.2DRD2, DRD4
465-hydroxytryptamine4410.2TDO2, DBH, TBXA2R, DRD4, DRD2, HTR3B
47methyldopa44 1111.2DBH, ADRA2A
48dopamine44 28 11 2413.1DRD2, DRD4, DRD5, DBH, ADRA2A
49epinephrine44 11 2412.0ADRA2A, DBH, DRD4, DRD2
50adenylate449.6DRD2, DRD4, TBXA2R, DBH, ADRA2A

GO Terms for genes affiliated with Gilles De La Tourette Syndrome

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16Gene Ontology
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Cellular components related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5ADRA2A, SGCE, TBXA2R, NKG7, DRD5, DRD4

Biological processes related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.5DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.5DRD2, DRD4
3response to histamineGO:03477610.5DRD2, DRD4
4phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.5DRD5, DRD2
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD2, DRD4
6fear responseGO:04259610.5ADRA2A, DBH, DRD4
7synaptic transmission, dopaminergicGO:00196310.4DRD2, DRD4, DRD5
8negative regulation of cAMP biosynthetic processGO:03081810.4DRD4, ADRA2A
9dopamine metabolic processGO:04241710.4DRD2, DRD4
10negative regulation of adenylate cyclase activityGO:00719410.4ADRA2A, DRD4, DRD2
11behavioral response to ethanolGO:04814910.4DBH, DRD4, DRD2
12negative regulation of protein secretionGO:05070910.4DRD2, DRD4
13cellular calcium ion homeostasisGO:00687410.4DRD5, DRD4, DRD2
14behavioral response to cocaineGO:04814810.3DRD2, DRD4
15response to amphetamineGO:00197510.3DRD2, DRD4, DRD5, DBH
16arachidonic acid secretionGO:05048210.3DRD4, DRD2
17associative learningGO:00830610.2DRD5, DRD2
18response to cocaineGO:04222010.2DRD5, DRD2
19positive regulation of vasoconstrictionGO:04590710.1TBXA2R, DBH
20activation of protein kinase activityGO:0321479.9ADRA2A, DRD2

Molecular functions related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.3DRD5, DRD4
2dopamine bindingGO:03524010.0DRD5, DRD4, DRD2
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.9DRD4, DRD2

Products for genes affiliated with Gilles De La Tourette Syndrome

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Sources for Gilles De La Tourette Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet