TD
MCID: GLL008
MIFTS: 73

Gilles De La Tourette Syndrome (TD) malady

Neuronal diseases category

Summaries for Gilles De La Tourette Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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NIH Rare Diseases:42 Tourette syndrome is a disorder of the nervous system that causes a person to make repeated and uncontrolled (involuntary) movements and sounds (vocalizations) called tics. tourette syndrome is named for georges gilles de la tourette, who first described this disorder in 1885. there is strong evidence that tourette syndrome is passed down through families, although the gene has not yet been found. the syndrome may be linked to problems in certain areas of the brain, and the chemical substances (dopamine, serotonin, and norepinephrine) that help nerve cells talk to one another. tourette syndrome can be either severe or mild. it is estimated that about 1% of the population has tourette syndrome. many people with very mild tics may not be aware of them and never seek medical help.   tourette syndrome is four times as likely to occur in boys as in girls.  although tourette syndrome can be a chronic condition with symptoms lasting a lifetime, most people with the condition experience their worst symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood. last updated: 7/14/2011

MalaCards: Gilles De La Tourette Syndrome, also known as tourette syndrome, is related to obsessive-compulsive disorder and hypertension. An important gene associated with Gilles De La Tourette Syndrome is SLITRK1 (SLIT and NTRK-like family, member 1), and among its related pathways are Dopamine receptors and Monoamine GPCRs. The drugs clonidine and haloperidol and the compounds (-)-sulpiride and zuclopenthixol have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.

Genetics Home Reference:21 Tourette syndrome is a complex disorder characterized by repetitive, sudden, and involuntary movements or noises called tics. Tics usually appear in childhood, and their severity varies over time. In most cases, tics become milder and less frequent in late adolescence and adulthood.

MedlinePlus:33 If you have tourette syndrome, you make unusual movements or sounds, called tics. you have little or no control over them. common tics are throat-clearing and blinking. you may repeat words, spin, or, rarely, blurt out swear words. tourette syndrome is a disorder of the nervous system. it often occurs with other problems, such as attention deficit hyperactivity disorder (adhd) obsessive-compulsive disorder (ocd) anxiety depression the cause of tourette syndrome is unknown. it is more common in boys than girls. the tics usually start in childhood and may be worst in the early teens. many people eventually outgrow them. no treatment is needed unless the tics interfere with everyday life. excitement or worry can make tics worse. calm, focused activities may make them better. medicines and talk therapy may also help. nih: national institute of neurological disorders and stroke

NINDS:43 Tourette syndrome (TS) is a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. The first symptoms of TS are almost always noticed in childhood. Some of the more common tics include eye blinking and other vision irregularities, facial grimacing, shoulder shrugging, and head or shoulder jerking. Perhaps the most dramatic and disabling tics are those that result in self-harm such as punching oneself in the face, or vocal tics including coprolalia (uttering swear words) or echolalia (repeating the words or phrases of others). Many with TS experience additional neurobehavioral problems including inattention, hyperactivity and impulsivity, and obsessive-compulsive symptoms such as intrusive thoughts/worries and repetitive behaviors.

Wikipedia:63 Tourette syndrome (also called Tourette\'s syndrome, Tourette\'s disorder, Gilles de la Tourette... more...

Description from OMIM:46 137580

GeneReviews summary for tourette

Aliases & Classifications for Gilles De La Tourette Syndrome

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8Disease Ontology, 19GeneReviews, 21Genetics Home Reference, 10DISEASES, 60UMLS, 9diseasecard, 42NIH Rare Diseases, 43NINDS, 46OMIM, 44Novoseek, 33MedlinePlus, 20GeneTests, 22GTR, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

gilles de la tourette syndrome 8 19 21 10 60
tourette syndrome 8 9 19 42 21 43 46 44 33
tourette's syndrome 42 20 22
tourette disorder 19 42 21
gilles de la tourette's syndrome 42 21
chronic motor and vocal tic disorder 21
thanatophoric dysplasia, type i 60
motor-verbal tic disorder 8
tourette's disease 21
psychogenic tics 8
guinon's disease 8
maladie de tics 19
gts 21
td 21
ts 21


External Ids:

Disease Ontology8 DOID:11119
ICD9CM27 307.23
MeSH34 D005879
NCIt39 C35078
OMIM46 137580
ICD1025 F95.1

Related Diseases for Gilles De La Tourette Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Gilles De La Tourette Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 695)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive disorder31.3DRD2, DRD4, TTF2, SGCE
2hypertension30.8DBH
3obesity30.7ADRA2A, TTF2, DRD4, DRD2, ISL1
4attention deficit hyperactivity disorder30.7DRD2, DRD4, DRD5, DBH, TTF2, ADRA2A
5schizophrenia30.6DRD2, DRD4, DRD5, DBH, TTF2, ADRA2A
6substance abuse30.5DRD4, DRD2
7pathological gambling30.3DRD2, DRD4
8migraine30.3DBH, DRD5, DRD4, DRD2
9alcohol dependence30.2DRD2, DRD4
10myoclonus-dystonia29.9DRD2, SGCE
11alcohol abuse29.9DRD2
12bipolar disorder29.9DBH, DRD5, DRD4, DRD2
13conduct disorder29.9DRD2, DRD4, DRD5, DBH, TTF2
14panic disorder29.8DRD4, TTF2
15wilson disease29.8SLITRK1, DRD2
16heroin dependence29.5DRD4, DRD2
17mood disorder29.5DRD2, DRD4, DBH, ADRA2A
18tic disorder10.8
19adult syndrome10.8
20thalassemia10.7
21breast cancer10.7
22colorectal cancer10.6
23coronary artery disease10.6
24chronic tic disorder10.6
25image syndrome10.6
26arthritis10.5
27myocardial infarction10.5
28hepatitis10.5
29lung cancer10.5
30alpha thalassemia10.5
31rheumatoid arthritis10.5
32beta thalassemia10.4
33parkinson's disease10.4
34rett syndrome10.4
35major depressive disorder10.4
36huntington's disease10.4
37cerebritis10.4
38pain disorder10.4
39neuronitis10.4
40echolalia10.4
41cervicitis10.4
42epilepsy syndrome10.4
43familial dystonia10.4
44impulse control disorder10.4
45movement disease10.4
46neuropathy10.4
47smith magenis syndrome10.4
48charge syndrome10.4
49townes-brocks syndrome10.4
50diabetes mellitus10.4

Graphical network of the top 20 diseases related to Gilles De La Tourette Syndrome:



Diseases related to gilles de la tourette syndrome

Clinical Features for Gilles De La Tourette Syndrome

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46OMIM
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Clinical features from OMIM:

137580

Clinical synopsis from OMIM:

137580

Drugs & Therapeutics for Gilles De La Tourette Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Gilles De La Tourette Syndrome

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Search CenterWatch for Gilles De La Tourette Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gilles De La Tourette Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Gilles De La Tourette Syndrome:

id Genetic test Affiliating Genes
1 Tourette Syndrome20 22 SLITRK1

Anatomical Context for Gilles De La Tourette Syndrome

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32MalaCards
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MalaCards organs/tissues related to Gilles De La Tourette Syndrome:

32
Brain, Eye, Cortex, Globus pallidus, Thalamus

Animal Models for Gilles De La Tourette Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gilles De La Tourette Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.3DRD4, IER3, TBXA2R, DBH, ROBO3, ROBO4
2MP:00036319.1TDO2, ISL1, DRD2, DRD4, DRD5, CBLN2
3MP:00053869.1CBLN2, DRD4, DRD2, ISL1, DBH, CNTNAP2
4MP:00053859.1ISL1, DRD2, DRD5, IER3, TBXA2R, DBH

Publications for Gilles De La Tourette Syndrome

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50PubMed
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Articles related to Gilles De La Tourette Syndrome:

(show top 50)    (show all 303)
idTitleAuthorsYear
1
Preface: the metamorphoses of Gilles de la Tourette syndrome. (24295632)
2013
2
Quality of life in adults with Gilles de la Tourette Syndrome. (22888766)
2012
3
Deep brain stimulation of the globus pallidus internus and Gilles de la Tourette syndrome: Toward multiple networks modulation. (22826816)
2012
4
Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome. (21442662)
2011
5
Motor tic of the neck: a probable cause of stroke in a child with Gilles de la Tourette syndrome. (21370260)
2011
6
Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report. (20520294)
2010
7
Aripiprazole in the pharmacotherapy of Gilles de la Tourette syndrome in adult patients. (18843565)
2009
8
Functional magnetic resonance imaging of tics and tic suppression in Gilles de la Tourette syndrome. (18609432)
2009
9
Transcranial magnetic stimulation in Gilles de la Tourette syndrome. (19913663)
2009
10
Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. (18454440)
2009
11
Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette syndrome. (18004766)
2008
12
The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies. (18940377)
2008
13
Contour copying or echoplasia--a new echo phenomenon in a person with Gilles de la Tourette syndrome. (18337631)
2008
14
A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 gene. (17712845)
2007
15
Clinical analysis of Gilles de la Tourette syndrome based on 126 cases. (18033637)
2007
16
Web-based consensus diagnosis for genetics studies of Gilles de la Tourette syndrome. (16536359)
2006
17
Gilles de la Tourette syndrome and voluntary movement: a functional MRI study. (15854795)
2005
18
Motor inhibition in patients with Gilles de la Tourette syndrome: functional activation patterns as revealed by EEG coherence. (15496435)
2005
19
Gilles de la Tourette syndrome treated effectively with Clozapine. (23377368)
2004
20
Gilles de la Tourette syndrome treated effectively with clozapine. (23649120)
2003
21
Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners. (11304830)
2001
22
Ophthalmic manifestations of Gilles de la Tourette syndrome. (11681499)
2001
23
S100B protein, glia and Gilles de la Tourette syndrome. (11277359)
2001
24
Gilles de la Tourette syndrome in a child with congenital deafness. (11794551)
2001
25
Genome scan for linkage to Gilles de la Tourette syndrome. (10402514)
1999
26
The effect of m-CPP on tics and obsessive-compulsive phenomena in Gilles de la Tourette syndrome. (10394994)
1999
27
The use of fluoxetine in Gilles de la Tourette syndrome and obsessive compulsive behaviours: preliminary clinical experience. (8843495)
1996
28
Abnormal topography of EEG microstates in Gilles de la Tourette syndrome. (8908413)
1996
29
Linkage studies on Gilles de la Tourette syndrome: what is the strategy of choice? (7668273)
1995
30
Misdiagnosis of Gilles de la Tourette syndrome. (7777984)
1995
31
Blunted growth hormone response to clonidine in Gilles de la Tourette syndrome. (8047638)
1994
32
Can children with Gilles de la Tourette syndrome edit their intentions? (8208891)
1994
33
Contingent negative variation in Gilles de la Tourette syndrome. (8261641)
1993
34
Gilles de la Tourette syndrome in the Middle East. Report of a cohort and a multiply affected large pedigree. (2036542)
1991
35
The Gilles de la Tourette syndrome and obsessional disorder. (1806636)
1991
36
Management of Gilles de la Tourette syndrome using sulpiride. (2357704)
1990
37
Gilles de la Tourette syndrome is not linked to D2-dopamine receptor. (1978653)
1990
38
Psychopathology and movement disorders: a new perspective on the Gilles de la Tourette syndrome. (2666582)
1989
39
Gilles de la Tourette syndrome: a review. (3522904)
1986
40
Gilles de la Tourette syndrome: an underdiagnosed disorder. (3860208)
1985
41
An atypical case of Gilles de la Tourette syndrome. (6595249)
1984
42
Serum haloperidol levels in Gilles de la Tourette syndrome. (6939449)
1981
43
Familial pattern and transmission of Gilles de la Tourette syndrome and multiple tics. (6945827)
1981
44
Gilles de la Tourette syndrome and compressive neuropathies. (6933884)
1980
45
Sleep in Gilles de la Tourette syndrome. (6932227)
1980
46
Improvement in Gilles de la Tourette syndrome after corticosteroid therapy. (281893)
1978
47
Stereotactic surgery in Gilles de la Tourette syndrome. (335809)
1977
48
HGPRT in the Gilles de la Tourette syndrome. (267247)
1977
49
Gilles de la Tourette syndrome: a case study. (812017)
1975
50
Psychotherapy with paraverbal therapy in a case of Gilles de la Tourette syndrome. (4507503)
1972

Genetic Variations for Gilles De La Tourette Syndrome

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Expression for genes affiliated with Gilles De La Tourette Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gilles De La Tourette Syndrome

Search GEO for disease gene expression data for Gilles De La Tourette Syndrome.

Pathways for genes affiliated with Gilles De La Tourette Syndrome

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1DRD5, DRD4, DRD2
2
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10.0ADRA2A, DRD5, DRD4, DRD2
3
Hide members
10.0DRD5, DRD4, DRD2, HTR3B
4
Hide members
9.9DRD2, DRD4, DRD5, TBXA2R, ADRA2A

Compounds for genes affiliated with Gilles De La Tourette Syndrome

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28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride2810.6DRD4, DRD2
2zuclopenthixol44 49 1112.6DRD5, ADRA2A, DRD2
3Thiethylperazine1110.6DRD2, DRD4
4Carphenazine1110.6DRD2, DRD5
5(+)-sulpiride2810.6DRD2, DRD4
6(+)-butaclamol28 4411.6DRD2, DRD4, DRD5
7melperone4410.5DRD4, DRD2
8cis flupentixol2810.5DRD5, DRD2
9piribedil28 4411.5DRD4, DRD2, ADRA2A
10rotigotine44 28 1112.5DRD2, DRD4, DRD5
11eticlopride28 4411.5DRD2, DRD4
12fluphenazine28 44 1112.5DRD5, DRD2, DRD4
13terguride28 4411.5DRD4, ADRA2A, DRD2
14spiperone28 4411.5DRD4, DRD5, DRD2
15paliperidone44 1111.5ADRA2A, DRD2, DRD4
16asenapine28 1111.5DRD4, DRD2, ADRA2A
17maoa4410.5DBH, DRD2, DRD4
18methylphenidate44 49 1112.5ADRA2A, DRD5, DRD4, DRD2
19ropinirole44 1111.5DRD2, ADRA2A, DRD5, DRD4
20alpha-methyl-p-tyrosine4410.5DBH, DRD2
21lisuride28 44 1112.5DRD4, ADRA2A, DRD2, DRD5
22pergolide28 44 1112.5ADRA2A, DRD4, DRD5, DRD2
23pramipexole44 49 28 1113.5DRD2, DRD4, ADRA2A, DRD5
24Methotrimeprazine1110.5DRD2, DRD5, DRD4, ADRA2A
25cabergoline28 44 1112.5DRD2, DRD4, ADRA2A, DRD5
26aripiprazole28 49 44 11 2414.5DRD4, DRD5, ADRA2A, DRD2
27ziprasidone49 28 44 1113.5ADRA2A, DRD5, DRD2, DRD4
28apomorphine44 28 1112.5DRD4, ADRA2A, DRD2, DRD5
29quetiapine44 49 28 11 2414.4DRD5, DRD2, DRD4, ADRA2A
30bromocriptine28 44 1112.4DRD4, DRD2, DRD5, ADRA2A
31chlorpromazine44 28 49 1113.4ADRA2A, DRD5, DRD4, DRD2
32nemonapride49 44 2812.4DRD4, DRD2
33olanzapine49 44 28 11 2414.4DRD4, ADRA2A, DRD5, DRD2
34risperidone28 44 49 59 11 2415.4DRD2, DRD4, ADRA2A
35catecholamine4410.4ADRA2A, DBH, DRD5, DRD4
36clozapine44 28 49 1113.4DRD5, ADRA2A, DRD2, DRD4
37Lurasidone1110.4ADRA2A, DRD2
38levodopa44 1111.4DRD4, DBH, DRD5, DRD2
39methamphetamine44 49 1112.4DRD2, DRD4, ADRA2A
40sch 233904410.3DRD4, DRD2
416-hydroxydopamine4410.3DRD4, DRD2, DBH
42methyldopa44 1111.3DBH, ADRA2A
43norepinephrine44 11 2412.3DBH, DRD4, DRD5, DRD2, ADRA2A
44nicotine44 49 28 1113.3DRD4, DRD2, DBH, TTF2
45loxapine28 44 1112.2DRD4, DRD2
465-hydroxytryptamine4410.2DRD4, HTR3B, TDO2, DBH, TBXA2R, DRD2
47remoxipride44 1111.1DRD2, DRD4
48dopamine44 28 11 2413.1DRD2, DRD4, DRD5, DBH, ADRA2A
49epinephrine44 11 2412.0DRD2, ADRA2A, DRD4, DBH
50adenylate449.6DBH, TBXA2R, DRD4, ADRA2A, DRD2

GO Terms for genes affiliated with Gilles De La Tourette Syndrome

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16Gene Ontology
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Cellular components related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5ADRA2A, SGCE, TBXA2R, NKG7, DRD5, DRD4

Biological processes related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.5DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.5DRD2, DRD4
3response to histamineGO:03477610.5DRD2, DRD4
4phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.5DRD5, DRD2
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD2, DRD4
6fear responseGO:04259610.5ADRA2A, DBH, DRD4
7synaptic transmission, dopaminergicGO:00196310.4DRD2, DRD4, DRD5
8negative regulation of cAMP biosynthetic processGO:03081810.4DRD4, ADRA2A
9dopamine metabolic processGO:04241710.4DRD2, DRD4
10negative regulation of adenylate cyclase activityGO:00719410.4ADRA2A, DRD4, DRD2
11behavioral response to ethanolGO:04814910.4DBH, DRD4, DRD2
12negative regulation of protein secretionGO:05070910.4DRD2, DRD4
13cellular calcium ion homeostasisGO:00687410.4DRD5, DRD4, DRD2
14behavioral response to cocaineGO:04814810.3DRD2, DRD4
15response to amphetamineGO:00197510.3DRD2, DRD4, DRD5, DBH
16arachidonic acid secretionGO:05048210.3DRD4, DRD2
17associative learningGO:00830610.2DRD5, DRD2
18response to cocaineGO:04222010.2DRD5, DRD2
19positive regulation of vasoconstrictionGO:04590710.1TBXA2R, DBH
20activation of protein kinase activityGO:0321479.9ADRA2A, DRD2

Molecular functions related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.3DRD5, DRD4
2dopamine bindingGO:03524010.0DRD5, DRD4, DRD2
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.9DRD4, DRD2

Products for genes affiliated with Gilles De La Tourette Syndrome

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Sources for Gilles De La Tourette Syndrome

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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
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39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
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