TD
MCID: GLL008
MIFTS: 60

Gilles De La Tourette Syndrome (TD) malady

Neuronal category

Summaries for Gilles De La Tourette Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Tourette syndrome is a disorder of the nervous system that causes a person to make repeated and uncontrolled (involuntary) movements and sounds (vocalizations) called tics. tourette syndrome is named for georges gilles de la tourette, who first described this disorder in 1885. there is strong evidence that tourette syndrome is passed down through families, although the gene has not yet been found. the syndrome may be linked to problems in certain areas of the brain, and the chemical substances (dopamine, serotonin, and norepinephrine) that help nerve cells talk to one another. tourette syndrome can be either severe or mild. it is estimated that about 1% of the population has tourette syndrome. many people with very mild tics may not be aware of them and never seek medical help.   tourette syndrome is four times as likely to occur in boys as in girls.  although tourette syndrome can be a chronic condition with symptoms lasting a lifetime, most people with the condition experience their worst symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood. last updated: 7/14/2011

MalaCards: Gilles De La Tourette Syndrome, also known as tourette syndrome, is related to obsessive-compulsive disorder and attention deficit hyperactivity disorder. An important gene associated with Gilles De La Tourette Syndrome is SLITRK1 (SLIT and NTRK-like family, member 1), and among its related pathways are Dopamine receptors and Monoamine GPCRs. The drugs clonidine and haloperidol and the compounds Carphenazine and Thiethylperazine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.

MedlinePlus:34 If you have tourette syndrome, you make unusual movements or sounds, called tics. you have little or no control over them. common tics are throat-clearing and blinking. you may repeat words, spin, or, rarely, blurt out swear words. tourette syndrome is a disorder of the nervous system. it often occurs with other problems, such as attention deficit hyperactivity disorder (adhd) obsessive-compulsive disorder (ocd) anxiety depression the cause of tourette syndrome is unknown. it is more common in boys than girls. the tics usually start in childhood and may be worst in the early teens. many people eventually outgrow them. no treatment is needed unless the tics interfere with everyday life. excitement or worry can make tics worse. calm, focused activities may make them better. medicines and talk therapy may also help. nih: national institute of neurological disorders and stroke

NINDS:44 Tourette syndrome (TS) is a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. The first symptoms of TS are almost always noticed in childhood. Some of the more common tics include eye blinking and other vision irregularities, facial grimacing, shoulder shrugging, and head or shoulder jerking. Perhaps the most dramatic and disabling tics are those that result in self-harm such as punching oneself in the face, or vocal tics including coprolalia (uttering swear words) or echolalia (repeating the words or phrases of others). Many with TS experience additional neurobehavioral problems including inattention, hyperactivity and impulsivity, and obsessive-compulsive symptoms such as intrusive thoughts/worries and repetitive behaviors.

Genetics Home Reference:21 Tourette syndrome is a complex disorder characterized by repetitive, sudden, and involuntary movements or noises called tics. Tics usually appear in childhood, and their severity varies over time. In most cases, tics become milder and less frequent in late adolescence and adulthood.

Wikipedia:64 Tourette syndrome (also called Tourette\'s syndrome, Tourette\'s disorder, Gilles de la Tourette... more...

Description from OMIM:47 137580

GeneReviews summary for tourette

Aliases & Classifications for Gilles De La Tourette Syndrome

Sources:
8Disease Ontology, 19GeneReviews, 21Genetics Home Reference, 10DISEASES, 61UMLS, 9diseasecard, 43NIH Rare Diseases, 44NINDS, 47OMIM, 45Novoseek, 34MedlinePlus, 20GeneTests, 22GTR, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

gilles de la tourette syndrome 8 19 21 10 61
tourette syndrome 8 9 19 43 21 44 47 45 34
tourette's syndrome 43 20 22
tourette disorder 19 43 21
gilles de la tourette's syndrome 43 21
chronic motor and vocal tic disorder 21
thanatophoric dysplasia, type i 61
motor-verbal tic disorder 8
tourette's disease 21
psychogenic tics 8
guinon's disease 8
maladie de tics 19
gts 21
td 21
ts 21


External Ids:

Disease Ontology8 DOID:11119
ICD9CM27 307.23
MeSH35 D005879
NCIt40 C35078
OMIM47 137580
ICD1025 F95.1

Related Diseases for Gilles De La Tourette Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Gilles De La Tourette Syndrome:



Diseases related to gilles de la tourette syndrome

Clinical Features for Gilles De La Tourette Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

137580

Clinical synopsis from OMIM:

137580

Drugs & Therapeutics for Gilles De La Tourette Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gilles De La Tourette Syndrome

Drug clinical trials:

Search ClinicalTrials for Gilles De La Tourette Syndrome

Search NIH Clinical Center for Gilles De La Tourette Syndrome

Search CenterWatch for Gilles De La Tourette Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Gilles De La Tourette Syndrome

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Gilles De La Tourette Syndrome:

id Genetic test Affiliating Genes
1 Tourette Syndrome20 22 SLITRK1

Anatomical Context for Gilles De La Tourette Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gilles De La Tourette Syndrome:

33
Brain

Animal Models for Gilles De La Tourette Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gilles De La Tourette Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.3DRD4, IER3, TBXA2R, DBH, ROBO3, ROBO4
2MP:00036319.1SGCE, ROBO3, TDO2, CNTNAP2, SLITRK1, CBLN2
3MP:00053869.1ISL1, DRD2, DRD4, DBH, CNTNAP2, ROBO3
4MP:00053859.1IER3, SGCE, ROBO4, DBH, TBXA2R, DRD5

Publications for Gilles De La Tourette Syndrome

Genetic Variations for Gilles De La Tourette Syndrome

Expression for genes affiliated with Gilles De La Tourette Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gilles De La Tourette Syndrome

Search GEO for disease gene expression data for Gilles De La Tourette Syndrome.

Pathways for genes affiliated with Gilles De La Tourette Syndrome

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1DRD5, DRD4, DRD2
2
Hide members
10.0ADRA2A, DRD5, DRD4, DRD2
3
Hide members
10.0DRD5, DRD4, DRD2, HTR3B
4
Hide members
9.9DRD2, DRD4, DRD5, TBXA2R, ADRA2A

Compounds for genes affiliated with Gilles De La Tourette Syndrome

Sources:
11DrugBank, 45Novoseek, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1Carphenazine1110.6DRD2, DRD5
2Thiethylperazine1110.6DRD2, DRD4
3zuclopenthixol45 50 1112.6DRD2, DRD5, ADRA2A
4(+)-sulpiride2910.6DRD2, DRD4
5(+)-butaclamol29 4511.6DRD2, DRD4, DRD5
6(-)-sulpiride2910.5DRD2, DRD4
7melperone4510.5DRD2, DRD4
8cis flupentixol2910.5DRD2, DRD5
9piribedil29 4511.5DRD2, DRD4, ADRA2A
10rotigotine45 29 1112.5DRD5, DRD4, DRD2
11eticlopride29 4511.5DRD2, DRD4
12fluphenazine29 45 1112.5DRD5, DRD4, DRD2
13terguride29 4511.5ADRA2A, DRD4, DRD2
14spiperone29 4511.5DRD2, DRD4, DRD5
15paliperidone45 1111.5ADRA2A, DRD4, DRD2
16asenapine29 1111.5ADRA2A, DRD4, DRD2
17maoa4510.5DBH, DRD4, DRD2
18methylphenidate45 50 1112.5DRD2, DRD4, DRD5, ADRA2A
19ropinirole45 1111.5DRD2, DRD4, DRD5, ADRA2A
20alpha-methyl-p-tyrosine4510.5DBH, DRD2
21lisuride29 45 1112.5ADRA2A, DRD5, DRD4, DRD2
22pergolide29 45 1112.5DRD2, DRD4, DRD5, ADRA2A
23Methotrimeprazine1110.5DRD2, DRD4, DRD5, ADRA2A
24pramipexole45 50 29 1113.5DRD2, DRD4, DRD5, ADRA2A
25cabergoline29 45 1112.5DRD2, DRD4, DRD5, ADRA2A
26aripiprazole29 50 45 11 2414.5ADRA2A, DRD5, DRD4, DRD2
27ziprasidone50 29 45 1113.5DRD2, DRD4, DRD5, ADRA2A
28apomorphine45 29 1112.5ADRA2A, DRD5, DRD4, DRD2
29quetiapine45 50 29 11 2414.4ADRA2A, DRD5, DRD4, DRD2
30bromocriptine29 45 1112.4DRD2, DRD4, DRD5, ADRA2A
31chlorpromazine45 29 50 1113.4DRD2, DRD4, DRD5, ADRA2A
32nemonapride50 45 2912.4DRD4, DRD2
33olanzapine50 45 29 11 2414.4DRD2, DRD4, DRD5, ADRA2A
34risperidone29 45 50 60 11 2415.4DRD2, DRD4, ADRA2A
35catecholamine4510.4DRD4, DRD5, DBH, ADRA2A
36clozapine45 29 50 1113.4DRD2, DRD4, DRD5, ADRA2A
37levodopa45 1111.4DRD2, DRD4, DRD5, DBH
38sch 233904510.4DRD4, DRD2
39methamphetamine45 50 1112.4DRD2, DRD4, ADRA2A
40Lurasidone1110.4ADRA2A, DRD2
416-hydroxydopamine4510.3DBH, DRD4, DRD2
42remoxipride45 1111.3DRD2, DRD4
43norepinephrine45 11 2412.3DRD2, DRD4, DRD5, DBH, ADRA2A
44nicotine45 50 29 1113.3TTF2, DBH, DRD4, DRD2
45loxapine29 45 1112.2DRD2, DRD4
465-hydroxytryptamine4510.2TDO2, DBH, TBXA2R, DRD4, DRD2, HTR3B
47methyldopa45 1111.2DBH, ADRA2A
48dopamine45 29 11 2413.1DRD2, DRD4, DRD5, DBH, ADRA2A
49epinephrine45 11 2412.0ADRA2A, DBH, DRD4, DRD2
50adenylate459.6DRD2, DRD4, TBXA2R, DBH, ADRA2A

GO Terms for genes affiliated with Gilles De La Tourette Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5ADRA2A, SGCE, TBXA2R, NKG7, DRD5, DRD4

Biological processes related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.5DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.5DRD2, DRD4
3response to histamineGO:03477610.5DRD2, DRD4
4phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.5DRD5, DRD2
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD2, DRD4
6fear responseGO:04259610.5ADRA2A, DBH, DRD4
7synaptic transmission, dopaminergicGO:00196310.4DRD2, DRD4, DRD5
8negative regulation of cAMP biosynthetic processGO:03081810.4DRD4, ADRA2A
9dopamine metabolic processGO:04241710.4DRD2, DRD4
10negative regulation of adenylate cyclase activityGO:00719410.4ADRA2A, DRD4, DRD2
11behavioral response to ethanolGO:04814910.4DBH, DRD4, DRD2
12negative regulation of protein secretionGO:05070910.4DRD2, DRD4
13cellular calcium ion homeostasisGO:00687410.4DRD5, DRD4, DRD2
14behavioral response to cocaineGO:04814810.3DRD2, DRD4
15response to amphetamineGO:00197510.3DRD2, DRD4, DRD5, DBH
16arachidonic acid secretionGO:05048210.3DRD4, DRD2
17associative learningGO:00830610.2DRD5, DRD2
18response to cocaineGO:04222010.2DRD5, DRD2
19positive regulation of vasoconstrictionGO:04590710.1TBXA2R, DBH
20activation of protein kinase activityGO:0321479.9ADRA2A, DRD2

Molecular functions related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.3DRD5, DRD4
2dopamine bindingGO:03524010.0DRD5, DRD4, DRD2
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.9DRD4, DRD2

Products for genes affiliated with Gilles De La Tourette Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gilles De La Tourette Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet