TD
MCID: GLL008
MIFTS: 73

Gilles De La Tourette Syndrome (TD) malady

Neuronal diseases category

Summaries for Gilles De La Tourette Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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NIH Rare Diseases:42 Tourette syndrome is a disorder of the nervous system that causes a person to make repeated and uncontrolled (involuntary) movements and sounds (vocalizations) called tics. tourette syndrome is named for georges gilles de la tourette, who first described this disorder in 1885. there is strong evidence that tourette syndrome is passed down through families, although the gene has not yet been found. the syndrome may be linked to problems in certain areas of the brain, and the chemical substances (dopamine, serotonin, and norepinephrine) that help nerve cells talk to one another. tourette syndrome can be either severe or mild. it is estimated that about 1% of the population has tourette syndrome. many people with very mild tics may not be aware of them and never seek medical help.   tourette syndrome is four times as likely to occur in boys as in girls.  although tourette syndrome can be a chronic condition with symptoms lasting a lifetime, most people with the condition experience their worst symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood. last updated: 7/14/2011

MalaCards: Gilles De La Tourette Syndrome, also known as tourette syndrome, is related to obsessive-compulsive disorder and hypertension. An important gene associated with Gilles De La Tourette Syndrome is SLITRK1 (SLIT and NTRK-like family, member 1), and among its related pathways are Dopamine receptors and Monoamine GPCRs. The drugs clonidine and haloperidol and the compounds (-)-sulpiride and zuclopenthixol have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.

Genetics Home Reference:21 Tourette syndrome is a complex disorder characterized by repetitive, sudden, and involuntary movements or noises called tics. Tics usually appear in childhood, and their severity varies over time. In most cases, tics become milder and less frequent in late adolescence and adulthood.

MedlinePlus:33 If you have tourette syndrome, you make unusual movements or sounds, called tics. you have little or no control over them. common tics are throat-clearing and blinking. you may repeat words, spin, or, rarely, blurt out swear words. tourette syndrome is a disorder of the nervous system. it often occurs with other problems, such as attention deficit hyperactivity disorder (adhd) obsessive-compulsive disorder (ocd) anxiety depression the cause of tourette syndrome is unknown. it is more common in boys than girls. the tics usually start in childhood and may be worst in the early teens. many people eventually outgrow them. no treatment is needed unless the tics interfere with everyday life. excitement or worry can make tics worse. calm, focused activities may make them better. medicines and talk therapy may also help. nih: national institute of neurological disorders and stroke

NINDS:43 Tourette syndrome (TS) is a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. The first symptoms of TS are almost always noticed in childhood. Some of the more common tics include eye blinking and other vision irregularities, facial grimacing, shoulder shrugging, and head or shoulder jerking. Perhaps the most dramatic and disabling tics are those that result in self-harm such as punching oneself in the face, or vocal tics including coprolalia (uttering swear words) or echolalia (repeating the words or phrases of others). Many with TS experience additional neurobehavioral problems including inattention, hyperactivity and impulsivity, and obsessive-compulsive symptoms such as intrusive thoughts/worries and repetitive behaviors.

Wikipedia:63 Tourette syndrome (also called Tourette\'s syndrome, Tourette\'s disorder, Gilles de la Tourette... more...

Description from OMIM:46 137580

GeneReviews summary for tourette

Aliases & Classifications for Gilles De La Tourette Syndrome

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8Disease Ontology, 19GeneReviews, 21Genetics Home Reference, 10DISEASES, 60UMLS, 9diseasecard, 42NIH Rare Diseases, 43NINDS, 46OMIM, 44Novoseek, 33MedlinePlus, 20GeneTests, 22GTR, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

gilles de la tourette syndrome 8 19 21 10 60
tourette syndrome 8 9 19 42 21 43 46 44 33
tourette's syndrome 42 20 22
tourette disorder 19 42 21
gilles de la tourette's syndrome 42 21
chronic motor and vocal tic disorder 21
thanatophoric dysplasia, type i 60
motor-verbal tic disorder 8
tourette's disease 21
psychogenic tics 8
guinon's disease 8
maladie de tics 19
gts 21
td 21
ts 21


External Ids:

Disease Ontology8 DOID:11119
ICD9CM27 307.23
MeSH34 D005879
NCIt39 C35078
OMIM46 137580
ICD1025 F95.1

Related Diseases for Gilles De La Tourette Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Gilles De La Tourette Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 695)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive disorder31.3DRD2, DRD4, TTF2, SGCE
2hypertension30.8DBH
3obesity30.7ADRA2A, TTF2, DRD4, DRD2, ISL1
4attention deficit hyperactivity disorder30.7DRD2, DRD4, DRD5, DBH, TTF2, ADRA2A
5schizophrenia30.6DRD2, DRD4, DRD5, DBH, TTF2, ADRA2A
6substance abuse30.5DRD4, DRD2
7pathological gambling30.3DRD2, DRD4
8migraine30.3DBH, DRD5, DRD4, DRD2
9alcohol dependence30.2DRD2, DRD4
10myoclonus-dystonia29.9DRD2, SGCE
11alcohol abuse29.9DRD2
12bipolar disorder29.9DBH, DRD5, DRD4, DRD2
13conduct disorder29.9DRD2, DRD4, DRD5, DBH, TTF2
14panic disorder29.8DRD4, TTF2
15wilson disease29.8SLITRK1, DRD2
16heroin dependence29.5DRD4, DRD2
17mood disorder29.5DRD2, DRD4, DBH, ADRA2A
18tic disorder10.8
19adult syndrome10.8
20thalassemia10.7
21breast cancer10.7
22colorectal cancer10.6
23coronary artery disease10.6
24chronic tic disorder10.6
25image syndrome10.6
26arthritis10.5
27myocardial infarction10.5
28hepatitis10.5
29lung cancer10.5
30alpha thalassemia10.5
31rheumatoid arthritis10.5
32beta thalassemia10.4
33parkinson's disease10.4
34rett syndrome10.4
35major depressive disorder10.4
36huntington's disease10.4
37cerebritis10.4
38pain disorder10.4
39neuronitis10.4
40echolalia10.4
41cervicitis10.4
42epilepsy syndrome10.4
43familial dystonia10.4
44impulse control disorder10.4
45movement disease10.4
46neuropathy10.4
47smith magenis syndrome10.4
48charge syndrome10.4
49townes-brocks syndrome10.4
50diabetes mellitus10.4

Graphical network of the top 20 diseases related to Gilles De La Tourette Syndrome:



Diseases related to gilles de la tourette syndrome

Clinical Features for Gilles De La Tourette Syndrome

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46OMIM
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Clinical features from OMIM:

137580

Clinical synopsis from OMIM:

137580

Drugs & Therapeutics for Gilles De La Tourette Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gilles De La Tourette Syndrome

Drug clinical trials:

Search ClinicalTrials for Gilles De La Tourette Syndrome

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Search CenterWatch for Gilles De La Tourette Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gilles De La Tourette Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Gilles De La Tourette Syndrome:

id Genetic test Affiliating Genes
1 Tourette Syndrome20 22 SLITRK1

Anatomical Context for Gilles De La Tourette Syndrome

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32MalaCards
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MalaCards organs/tissues related to Gilles De La Tourette Syndrome:

32
Brain, Eye, Cortex, Globus pallidus, Thalamus

Animal Models for Gilles De La Tourette Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gilles De La Tourette Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.3DRD4, IER3, TBXA2R, DBH, ROBO3, ROBO4
2MP:00036319.1TDO2, ISL1, DRD2, DRD4, DRD5, CBLN2
3MP:00053869.1CBLN2, DRD4, DRD2, ISL1, DBH, CNTNAP2
4MP:00053859.1ISL1, DRD2, DRD5, IER3, TBXA2R, DBH

Publications for Gilles De La Tourette Syndrome

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50PubMed
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Articles related to Gilles De La Tourette Syndrome:

(show top 50)    (show all 303)
idTitleAuthorsYear
1
The psychopathological spectrum of Gilles de la Tourette syndrome. (23131314)
2013
2
Health-related quality of life in Gilles de la Tourette syndrome: a decade of research. (23187148)
2013
3
What patients with gilles de la tourette syndrome should be treated with deep brain stimulation and what is the best target? (22407075)
2012
4
Motor-cortical interaction in Gilles de la Tourette syndrome. (22238571)
2012
5
The Gilles de la Tourette syndrome: the current status. (22440810)
2012
6
Increasing histamine neurotransmission in Gilles de la Tourette syndrome. (21779959)
2012
7
Prevalence and phenomenology of eye tics in Gilles de la Tourette syndrome. (22434162)
2012
8
Reinforcement learning and Gilles de la Tourette syndrome: dissociation of clinical phenotypes and pharmacological treatments. (22147843)
2011
9
Imitation in patients with Gilles de la Tourette syndrome--a behavioral study. (20535824)
2010
10
The many faces of Gilles de la Tourette syndrome. (19913649)
2009
11
Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome. (19136548)
2009
12
Motor cortex excitability and comorbidity in Gilles de la Tourette syndrome. (18931001)
2009
13
Psychopathological features of obsessive-compulsive disorder in an Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. (18722020)
2008
14
Hassler and Dieckmann's seminal paper on stereotactic thalamotomy for Gilles de la Tourette syndrome: translation and critical reappraisal. (18792123)
2008
15
Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder. (17453897)
2007
16
Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndrome. (16500943)
2006
17
Ropinirole in Gilles de la Tourette syndrome. (15136698)
2004
18
Screening for mutations in the MECP2 (Rett syndrome) gene in Gilles de la Tourette syndrome. (12707062)
2003
19
Evaluation of the genes for the adrenergic receptors alpha 2A and alpha 1C and Gilles de la Tourette Syndrome. (12707939)
2003
20
Uncomplicated Gilles de la Tourette syndrome and probable Ganser syndrome. A case report and review of the literature. (12469241)
2002
21
History of tic disorders and Gilles de la Tourette syndrome: part 5 of the MDS-sponsored history of movement disorders exhibit, Barcelona, June 2000. (11295792)
2001
22
Color vision deficiencies in Gilles de la Tourette syndrome. (11412879)
2001
23
Dopamine transporter binding in Gilles de la Tourette syndrome. (10993492)
2000
24
Breakpoint sequences of an 1;8 translocation in a family with Gilles de la Tourette syndrome. (11093278)
2000
25
Gilles de la Tourette syndrome: symptomatic treatment based on evidence. (11140781)
2000
26
Gilles de la Tourette syndrome with schizophrenia and obsessive-compulsive disorder: a case report. (10570769)
1999
27
The temporal dynamics of tics in Gilles de la Tourette syndrome. (9861477)
1998
28
Hyperkinetic movement disorders misdiagnosed as tics in Gilles de la Tourette syndrome. (9613740)
1998
29
Directed attention in Gilles de la Tourette syndrome. (11568405)
1998
30
Autonomic regulation during rest and mental load in Gilles de la Tourette syndrome. (9819927)
1998
31
Gilles de la Tourette syndrome. (9488798)
1997
32
Postprandial changes in superoxide dismutase activity in subjects with Gilles de la Tourette syndrome and controls. (9168842)
1997
33
Risperidone in Gilles de la Tourette syndrome. (7542376)
1995
34
Coprolalia in younger patients with Gilles de la Tourette syndrome. (7845402)
1994
35
Altered attentional processing of background stimuli in Gilles de la Tourette syndrome: a study in auditory event-related potentials evoked in an oddball paradigm. (7801737)
1994
36
Samuel Johnson: victim of Gilles de la Tourette syndrome. (8270933)
1993
37
Non-invasive assessment of autonomic nervous function in Gilles de la Tourette syndrome. (1324814)
1992
38
Auditory evoked potentials in Gilles de la Tourette syndrome. (1733618)
1992
39
Reflex tics in two patients with Gilles de la Tourette syndrome. (1790463)
1991
40
Gilles de la Tourette syndrome. (3165566)
1988
41
Contingent negative variation in adults with Gilles de la Tourette syndrome. (3165440)
1988
42
Treatment of Gilles de la Tourette syndrome with depot neuroleptics. (6591768)
1984
43
Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research. (6324164)
1983
44
Gilles de la Tourette syndrome. (6959482)
1982
45
Sensory experiences of Gilles de la Tourette syndrome. (6934713)
1980
46
Deleterious effects of drugs used for hyperactivity on patients with Gilles de la Tourette syndrome. (6929749)
1980
47
Noradrenergic and dopaminergic mechanisms in Gilles de la Tourette syndrome. (76814)
1978
48
Gilles de la Tourette syndrome: a 20-month study of the effects of stressful life events and haloperidol on symptom frequency. (281456)
1978
49
Familial occurrence of Gilles de la Tourette syndrome. Report of the syndrome occurring in a father and son. (4510886)
1973
50
The Gilles de la Tourette syndrome. (4224886)
1966

Genetic Variations for Gilles De La Tourette Syndrome

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Expression for genes affiliated with Gilles De La Tourette Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gilles De La Tourette Syndrome

Search GEO for disease gene expression data for Gilles De La Tourette Syndrome.

Pathways for genes affiliated with Gilles De La Tourette Syndrome

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1DRD5, DRD4, DRD2
2
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10.0ADRA2A, DRD5, DRD4, DRD2
3
Hide members
10.0DRD5, DRD4, DRD2, HTR3B
4
Hide members
9.9DRD2, DRD4, DRD5, TBXA2R, ADRA2A

Compounds for genes affiliated with Gilles De La Tourette Syndrome

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28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride2810.6DRD4, DRD2
2zuclopenthixol44 49 1112.6DRD5, ADRA2A, DRD2
3Thiethylperazine1110.6DRD2, DRD4
4Carphenazine1110.6DRD2, DRD5
5(+)-sulpiride2810.6DRD2, DRD4
6(+)-butaclamol28 4411.6DRD2, DRD4, DRD5
7melperone4410.5DRD4, DRD2
8cis flupentixol2810.5DRD5, DRD2
9piribedil28 4411.5DRD4, DRD2, ADRA2A
10rotigotine44 28 1112.5DRD2, DRD4, DRD5
11eticlopride28 4411.5DRD2, DRD4
12fluphenazine28 44 1112.5DRD5, DRD2, DRD4
13terguride28 4411.5DRD4, ADRA2A, DRD2
14spiperone28 4411.5DRD4, DRD5, DRD2
15paliperidone44 1111.5ADRA2A, DRD2, DRD4
16asenapine28 1111.5DRD4, DRD2, ADRA2A
17maoa4410.5DBH, DRD2, DRD4
18methylphenidate44 49 1112.5ADRA2A, DRD5, DRD4, DRD2
19ropinirole44 1111.5DRD2, ADRA2A, DRD5, DRD4
20alpha-methyl-p-tyrosine4410.5DBH, DRD2
21lisuride28 44 1112.5DRD4, ADRA2A, DRD2, DRD5
22pergolide28 44 1112.5ADRA2A, DRD4, DRD5, DRD2
23pramipexole44 49 28 1113.5DRD2, DRD4, ADRA2A, DRD5
24Methotrimeprazine1110.5DRD2, DRD5, DRD4, ADRA2A
25cabergoline28 44 1112.5DRD2, DRD4, ADRA2A, DRD5
26aripiprazole28 49 44 11 2414.5DRD4, DRD5, ADRA2A, DRD2
27ziprasidone49 28 44 1113.5ADRA2A, DRD5, DRD2, DRD4
28apomorphine44 28 1112.5DRD4, ADRA2A, DRD2, DRD5
29quetiapine44 49 28 11 2414.4DRD5, DRD2, DRD4, ADRA2A
30bromocriptine28 44 1112.4DRD4, DRD2, DRD5, ADRA2A
31chlorpromazine44 28 49 1113.4ADRA2A, DRD5, DRD4, DRD2
32nemonapride49 44 2812.4DRD4, DRD2
33olanzapine49 44 28 11 2414.4DRD4, ADRA2A, DRD5, DRD2
34risperidone28 44 49 59 11 2415.4DRD2, DRD4, ADRA2A
35catecholamine4410.4ADRA2A, DBH, DRD5, DRD4
36clozapine44 28 49 1113.4DRD5, ADRA2A, DRD2, DRD4
37Lurasidone1110.4ADRA2A, DRD2
38levodopa44 1111.4DRD4, DBH, DRD5, DRD2
39methamphetamine44 49 1112.4DRD2, DRD4, ADRA2A
40sch 233904410.3DRD4, DRD2
416-hydroxydopamine4410.3DRD4, DRD2, DBH
42methyldopa44 1111.3DBH, ADRA2A
43norepinephrine44 11 2412.3DBH, DRD4, DRD5, DRD2, ADRA2A
44nicotine44 49 28 1113.3DRD4, DRD2, DBH, TTF2
45loxapine28 44 1112.2DRD4, DRD2
465-hydroxytryptamine4410.2DRD4, HTR3B, TDO2, DBH, TBXA2R, DRD2
47remoxipride44 1111.1DRD2, DRD4
48dopamine44 28 11 2413.1DRD2, DRD4, DRD5, DBH, ADRA2A
49epinephrine44 11 2412.0DRD2, ADRA2A, DRD4, DBH
50adenylate449.6DBH, TBXA2R, DRD4, ADRA2A, DRD2

GO Terms for genes affiliated with Gilles De La Tourette Syndrome

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16Gene Ontology
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Cellular components related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5ADRA2A, SGCE, TBXA2R, NKG7, DRD5, DRD4

Biological processes related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.5DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.5DRD2, DRD4
3response to histamineGO:03477610.5DRD2, DRD4
4phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.5DRD5, DRD2
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD2, DRD4
6fear responseGO:04259610.5ADRA2A, DBH, DRD4
7synaptic transmission, dopaminergicGO:00196310.4DRD2, DRD4, DRD5
8negative regulation of cAMP biosynthetic processGO:03081810.4DRD4, ADRA2A
9dopamine metabolic processGO:04241710.4DRD2, DRD4
10negative regulation of adenylate cyclase activityGO:00719410.4ADRA2A, DRD4, DRD2
11behavioral response to ethanolGO:04814910.4DBH, DRD4, DRD2
12negative regulation of protein secretionGO:05070910.4DRD2, DRD4
13cellular calcium ion homeostasisGO:00687410.4DRD5, DRD4, DRD2
14behavioral response to cocaineGO:04814810.3DRD2, DRD4
15response to amphetamineGO:00197510.3DRD2, DRD4, DRD5, DBH
16arachidonic acid secretionGO:05048210.3DRD4, DRD2
17associative learningGO:00830610.2DRD5, DRD2
18response to cocaineGO:04222010.2DRD5, DRD2
19positive regulation of vasoconstrictionGO:04590710.1TBXA2R, DBH
20activation of protein kinase activityGO:0321479.9ADRA2A, DRD2

Molecular functions related to Gilles De La Tourette Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.3DRD5, DRD4
2dopamine bindingGO:03524010.0DRD5, DRD4, DRD2
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.9DRD4, DRD2

Products for genes affiliated with Gilles De La Tourette Syndrome

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Sources for Gilles De La Tourette Syndrome

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3CDC
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22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet