MCID: GNG012
MIFTS: 52

Gingival Overgrowth malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Gingival Overgrowth

Aliases & Descriptions for Gingival Overgrowth:

Name: Gingival Overgrowth 12 29 52 42 14
Gingival Enlargement Nos 12
Gingival Enlargement 12
Gingival Hyperplasia 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3086
ICD10 33 K06.1
MeSH 42 D019214
UMLS 69 C0376480

Summaries for Gingival Overgrowth

MalaCards based summary : Gingival Overgrowth, also known as gingival enlargement nos, is related to gingival fibromatosis and amelogenesis imperfecta, type ig. An important gene associated with Gingival Overgrowth is MMP1 (Matrix Metallopeptidase 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cyclosporine and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 71 Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia,... more...

Related Diseases for Gingival Overgrowth

Diseases related to Gingival Overgrowth via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Related Disease Score Top Affiliating Genes
1 gingival fibromatosis 11.4
2 amelogenesis imperfecta, type ig 11.0
3 gingivitis 11.0
4 epulis 10.8
5 periodontitis 10.5
6 miliaria 10.2 CTGF TGFB1
7 amelogenesis imperfecta 1j 10.2 CD36 DCN
8 geleophysic dysplasia 2 10.2 CTGF TGFB1
9 symmastia 10.2 MMP1 MMP3
10 leber congenital amaurosis 10.2 CD36 MMP1 TGFB1
11 chronic diarrhea due to guanylate cyclase 2c overactivity 10.2 DCN MMP1
12 alternating esotropia 10.2 CD36 DCN
13 lymphangiectasia, intestinal 10.2 CD36 CTGF TGFB1
14 speech and communication disorders 10.2 CD36 TGFB1 TIMP1
15 diffuse large b-cell lymphoma 10.2 MMP1 PDGFB TGFB1
16 breast abscess 10.2 IL6 MMP1 TIMP1
17 calcinosis 10.2 CTGF IL6 TGFB1
18 albinism, oculocutaneous, type ia 10.1 CTGF TGFB1 TIMP1
19 hemorrhagic cystitis 10.1 CD36 CTGF TGFB1
20 kleptomania 10.1 MMP1 MMP3
21 aphthous stomatitis 10.1 CTGF TGFB1
22 patent foramen ovale 10.1 CTGF TGFB1 TIMP1
23 upper respiratory tract disease 10.1 CTGF PDGFB TGFB1
24 onychocytic matricoma 10.1 CD36 DCN MMP1
25 central nervous system teratoma 10.1 IL6 MMP1 TIMP1
26 anhidrosis 10.1 CTGF TGFB1
27 pituitary infarct 10.1 IL6 MMP3 TGFB1
28 pasteurellosis 10.1 IL6 MMP1 MMP3
29 carotenemia 10.1 IL6 MMP1 MMP3
30 angiomyoma 10.1 MMP1 MMP3 TIMP1
31 keratoconus 10.1 IL6 MMP3 TIMP1
32 synovium cancer 10.1 IL6 MMP1 MMP3
33 chordoid meningioma 10.1 IL6 MMP3 TIMP1
34 neuroectodermal endocrine syndrome 10.0 CTGF DCN TGFB1 TIMP1
35 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 10.0 IL6 MMP3 TIMP1
36 mental retardation, autosomal recessive 40 10.0 CTGF MMP1 MMP3
37 burns 10.0 IL6 PDGFB TGFB1 TIMP1
38 basilar artery insufficiency 10.0 CD36 IL6 TGFB1
39 renal tubular acidosis 10.0 CTGF PDGFB TGFB1 TIMP1
40 anal paget's disease 10.0 IL1A IL6 TGFB1
41 noonan syndrome 4 10.0 CD36 FAM20A MMP1 TGFB1
42 immunoglobulin g deficiency 10.0 IL1A IL6 TGFB1
43 autosomal recessive type iv ehlers-danlos syndrome 10.0 IL1A IL6 MMP1
44 mixed ductal-endocrine carcinoma 10.0 IL6 MMP1 MMP3 TIMP1
45 baritosis 10.0 IL1A IL6 TGFB1
46 swine influenza 10.0 IL1A IL6
47 hereditary night blindness 10.0 CTGF DCN IL6 MMP1 TGFB1
48 epilepsy 9.9
49 endotheliitis 9.9
50 kashin-beck disease 9.9 DCN MMP1 MMP3 TIMP1

Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to Gingival Overgrowth

Symptoms & Phenotypes for Gingival Overgrowth

MGI Mouse Phenotypes related to Gingival Overgrowth:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 PDGFB TGFB1 TIMP1 CD36 CTGF CTSB
2 growth/size/body region MP:0005378 10.13 CD36 CTGF CTSB DCN FAM20A IL6
3 cardiovascular system MP:0005385 10.11 CD36 CTGF FAM20A IL1A IL6 PDGFB
4 immune system MP:0005387 10.1 CD36 CTSB DCN IL1A IL6 MMP1
5 hematopoietic system MP:0005397 10.06 CD36 DCN IL1A IL6 MMP3 PDGFB
6 digestive/alimentary MP:0005381 9.97 CD36 CTGF CTSB DCN IL6 TGFB1
7 integument MP:0010771 9.91 IL6 PDGFB TGFB1 CTGF CTSB DCN
8 neoplasm MP:0002006 9.87 CTSB DCN IL1A IL6 MMP1 TGFB1
9 renal/urinary system MP:0005367 9.8 CD36 CTSB DCN FAM20A IL6 PDGFB
10 respiratory system MP:0005388 9.7 CTGF DCN FAM20A IL6 PDGFB TGFB1
11 skeleton MP:0005390 9.56 CD36 CTGF DCN FAM20A IL6 MMP3
12 vision/eye MP:0005391 9.17 TGFB1 FAM20A IL6 PDGFB CD36 CTGF

Drugs & Therapeutics for Gingival Overgrowth

Drugs for Gingival Overgrowth (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclosporine Approved, Investigational, Vet_approved Phase 4 79217-60-0, 59865-13-3 5284373 6435893
2
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4 Dermatologic Agents Phase 4,Phase 2
5 Anti-Infective Agents Phase 4,Phase 2
6 Immunosuppressive Agents Phase 4
7 Antifungal Agents Phase 4
8 Antirheumatic Agents Phase 4
9 Calcineurin Inhibitors Phase 4
10
Phenytoin Approved, Vet_approved Phase 3 57-41-0 1775
11
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
13 Sodium Channel Blockers Phase 3
14 Hematinics Phase 3
15 Trace Elements Phase 3
16 Diuretics, Potassium Sparing Phase 3
17 Vitamin B Complex Phase 3
18 Vitamins Phase 3
19 Anticonvulsants Phase 3
20 Micronutrients Phase 3
21 Folate Nutraceutical Phase 3
22 Vitamin B9 Nutraceutical Phase 3
23
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 9552079 2713
24 Chlorhexidine gluconate Phase 2
25 Disinfectants Phase 2
26 Anti-Infective Agents, Local Phase 2
27
Salicylic acid Approved, Vet_approved 69-72-7 338
28 calcium channel blockers
29 Calcium, Dietary

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy and Safety Study of the Switch From Cyclosporin to Tacrolimus in Renal Transplant Recipients Completed NCT02706678 Phase 4
2 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4
3 Folic Acid Supplementation in Phenytoin Induced Gingival Overgrowth Completed NCT00781196 Phase 3
4 Effect of Supragingival Irrigators Containing Chlorhexidine on Oral Health in Blood Dyscrasia Completed NCT01974401 Phase 2
5 Diode Laser in Gingival Enlargement Related to Orthodontics Unknown status NCT01286298
6 Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth Completed NCT00104026
7 Flapless Esthetic Crown Lengthening for the Treatment of Excessive Gingival Display Completed NCT01821157
8 Study of Immunosuppressive Therapy Toxicities in Kidney Transplant Recipients at Regional or Satellite Community Clinics Completed NCT00902980
9 Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease Completed NCT02187185
10 IL29 and IL28B Variants Associated With Periodontal Disease Pathogenesis Recruiting NCT02710903

Search NIH Clinical Center for Gingival Overgrowth

Cochrane evidence based reviews: gingival overgrowth

Genetic Tests for Gingival Overgrowth

Genetic tests related to Gingival Overgrowth:

id Genetic test Affiliating Genes
1 Gingival Overgrowth 29

Anatomical Context for Gingival Overgrowth

MalaCards organs/tissues related to Gingival Overgrowth:

39
Heart, Kidney, Liver, Endothelial, Lung, Bone, Bone Marrow

Publications for Gingival Overgrowth

Articles related to Gingival Overgrowth:

(show top 50) (show all 441)
id Title Authors Year
1
Efficacy of azithromycin and metronidazole combined therapy on rats' gingival overgrowth induced by cyclosporine-A: An experimental animal study. ( 27761387 )
2016
2
Gingival Crevicular Fluid and Plasma Levels of Transglutaminase-2 and Oxidative Stress Markers in Cylosporin A-Induced Gingival Overgrowth. ( 27468796 )
2016
3
Upregulation of Slug expression by cyclosporine A contributes to the pathogenesis of gingival overgrowth. ( 27287534 )
2016
4
An unusual case report of gingival overgrowth associated with the use of leflunomide. ( 27606481 )
2016
5
Amlodipine-Induced Gingival Overgrowth. ( 27731568 )
2016
6
A Clinical Evaluation of Gingival Overgrowth in Children on Antiepileptic Drug Therapy. ( 26894172 )
2016
7
Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18I+-glycyrrhetinic acid inhibits human gingival fibroblast growth. ( 26676684 )
2016
8
Immunohistochemical Localization of Epithelial Mesenchymal Transition Markers in Cyclosporine A Induced Gingival Overgrowth. ( 27656563 )
2016
9
In vivo association of immunophenotyped macrophages expressing CD163 with PDGF-B in gingival overgrowth-induced by three different categories of medications. ( 26937363 )
2016
10
Experimental animal model in a histological study of drug-induced gingival overgrowth. ( 28002516 )
2016
11
Immunoexpression of interleukin-6 in drug-induced gingival overgrowth patients. ( 27307657 )
2016
12
Biological roles of KGF, CTGF and TGF-I^ in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study. ( 26894526 )
2016
13
Loss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowth. ( 27281036 )
2016
14
Amlodipine-induced gingival overgrowth in a child after liver transplant. ( 27818959 )
2016
15
Gingival overgrowth due to amlodipine. ( 27316509 )
2016
16
Local cause of gingival overgrowth. Clinical and histological study. ( 27516015 )
2016
17
Gingival Overgrowth Leading to the Diagnosis of Familial Tuberous Sclerosis Complex. ( 26885413 )
2016
18
An unusual case report of gingival overgrowth associated with the use of leflunomide. ( 27061898 )
2016
19
Cellular crosstalk mechanism of Toll-like receptors in gingival overgrowth (Review). ( 25812632 )
2015
20
Prevention of Phenytoin-Induced Gingival Overgrowth by Lovastatin in Mice. ( 25843680 )
2015
21
Angiotensin II Levels in Gingival Tissues from Healthy Individuals, Patients with Nifedipine Induced Gingival Overgrowth and Non Responders on Nifedipine. ( 26436057 )
2015
22
Case report: drug-induced gingival overgrowth associated with the use of a calcium channel blocker (amlodipine). ( 26665904 )
2015
23
Drug induced gingival overgrowth: a rare case report. ( 25738096 )
2015
24
Prevalence of gingival overgrowth induced by antihypertensive drugs: A hospital-based study. ( 26229273 )
2015
25
Cyclosporine A: Novel concepts in its role in drug-induced gingival overgrowth. ( 26759584 )
2015
26
Elevated Snail expression in human gingival fibroblasts by cyclosporine A as the possible pathogenesis for gingival overgrowth. ( 26691272 )
2015
27
Ca-channel blocker-induced gingival overgrowth that improved with non-surgical therapy during visiting care: a case report. ( 26205140 )
2015
28
Phenytoin-induced gingival overgrowth management with periodontal treatment. ( 25672382 )
2015
29
Interleukin-6 Family of Cytokines in Crevicular Fluid of Renal Transplant Recipients With and Without Cyclosporine A-Induced Gingival Overgrowth. ( 25927423 )
2015
30
Management of Gingival Overgrowth in a Cardiac Transplant Patient Using Laser-Assisted Gingivectomy/Gingivoplasty. ( 26373224 )
2015
31
Molecular and Clinical Aspects of Drug-induced Gingival Overgrowth. ( 25680368 )
2015
32
Severe Antiepileptic Drug-induced Gingival Overgrowth in a Physically Disabled Patient. ( 26907979 )
2015
33
Using Salivary Nitrite and Nitrate Levels as a Biomarker for Drug-Induced Gingival Overgrowth. ( 26649282 )
2015
34
Transglutaminase 2 May Be Associated with Peri-implant Gingival Overgrowth: Preliminary Assessments. ( 26523722 )
2015
35
Impact of three different mouthwashes on the incidence of gingival overgrowth induced by cyclosporine-A: a randomized controlled experimental animal study. ( 26153120 )
2015
36
Management of periodontal disease in patients using calcium channel blockers - gingival overgrowth, prescribed medications, treatment responses and added treatment costs. ( 26076712 )
2015
37
Local Inflammation Alters MMP-2 and MMP-9 Gelatinase Expression Associated with the Severity of Nifedipine-Induced Gingival Overgrowth: a Rat Model Study. ( 25652432 )
2015
38
Are antimicrobial peptides related to cyclosporine A-induced gingival overgrowth? ( 25555253 )
2015
39
Gingival overgrowth as secondary effect of calcium channel blockers administration. A case report. ( 25408733 )
2014
40
Incidence of amlodipine-induced gingival overgrowth in the rural population of Loni. ( 24872633 )
2014
41
Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth. ( 24581850 )
2014
42
Treatment of drug-induced gingival overgrowth by full-mouth disinfection: A non-surgical approach. ( 25024543 )
2014
43
Role of transforming growth factor I^-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth. ( 24969976 )
2014
44
Nonsurgical management of nifedipine induced gingival overgrowth. ( 25165585 )
2014
45
Is periodontal health a predictor of drug-induced gingival overgrowth? A cross-sectional study. ( 25426150 )
2014
46
Conflation of gingival overgrowth and schwannoma. ( 25331149 )
2014
47
Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis. ( 24893951 )
2014
48
Gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection: a case report. ( 25548632 )
2014
49
The effect of nonsurgical periodontal treatment on the severity of drug-induced gingival overgrowth in transplant patients. ( 24389563 )
2014
50
Elevated levels of cyclooxygenase 1 and 2 in human cyclosporine induced gingival overgrowth. ( 25124319 )
2014

Variations for Gingival Overgrowth

ClinVar genetic disease variations for Gingival Overgrowth:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic/Likely pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416

Copy number variations for Gingival Overgrowth from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 116297 17 64200000 70900000 Copy number Gingival hyperplasia

Expression for Gingival Overgrowth

Search GEO for disease gene expression data for Gingival Overgrowth.

Pathways for Gingival Overgrowth

Pathways related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CD36 CTSB CTSL IL1A IL6 MMP1
2
Show member pathways
13.29 CTGF IL1A IL6 PDGFB TGFB1 TIMP1
3
Show member pathways
13.14 CTGF IL1A IL6 PDGFB TGFB1 TIMP1
4
Show member pathways
13.12 CD36 IL1A IL6 MMP1 MMP3 PDGFB
5
Show member pathways
12.93 CTGF IL6 PDGFB TGFB1 TIMP1
6
Show member pathways
12.92 CTGF IL6 PDGFB TGFB1 TIMP1
7
Show member pathways
12.71 CTSB CTSL IL1A IL6 TGFB1
8 12.56 IL6 MMP1 PDGFB TGFB1
9
Show member pathways
12.46 CTGF IL1A IL6 PDGFB TGFB1 TIMP1
10
Show member pathways
12.41 CTSB CTSL DCN MMP1 MMP3 PDGFB
11
Show member pathways
12.07 CTSB CTSL IL6
12 12.06 IL6 MMP1 TGFB1
13 11.98 CTSL IL1A PDGFB
14 11.96 IL6 PDGFB TGFB1
15 11.89 IL1A IL6 TGFB1
16 11.82 IL1A IL6 TGFB1
17 11.79 IL1A IL6 TGFB1
18
Show member pathways
11.78 MMP1 MMP3 TIMP1
19 11.77 CD36 IL1A IL6
20 11.72 DCN IL6 PDGFB TGFB1
21 11.71 MMP3 TGFB1 TIMP1
22 11.61 CD36 IL6 TGFB1
23 11.54 CTGF IL6 PDGFB TGFB1 TIMP1
24 11.53 MMP1 MMP3 TIMP1
25 11.45 CTGF IL6 PDGFB TGFB1 TIMP1
26 11.43 IL6 MMP1 TGFB1
27
Show member pathways
11.42 IL1A IL6 MMP1 MMP3
28 11.4 IL1A IL6 TIMP1
29 11.39 CD36 IL6 TGFB1
30 11.39 CTSL IL1A IL6 MMP1 MMP3 TGFB1
31 11.37 IL6 PDGFB TGFB1
32 11.22 CD36 IL1A IL6 MMP1 MMP3 TGFB1
33 11.2 DCN IL6 MMP1
34 11.13 IL1A IL6 TGFB1
35 10.93 MMP1 TIMP1
36 10.87 MMP1 TGFB1
37 10.8 IL6 TGFB1

GO Terms for Gingival Overgrowth

Cellular components related to Gingival Overgrowth according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.73 CTGF DCN MMP1 MMP3 TGFB1 TIMP1
2 extracellular region GO:0005576 9.73 CTGF CTSB CTSL DCN FAM20A IL1A
3 extracellular matrix GO:0031012 9.63 DCN MMP1 MMP3 PDGFB TGFB1 TIMP1
4 Golgi lumen GO:0005796 9.58 DCN PDGFB TGFB1
5 platelet alpha granule lumen GO:0031093 9.54 PDGFB TGFB1 TIMP1
6 extracellular space GO:0005615 9.4 CD36 CTGF CTSB CTSL DCN FAM20A
7 endolysosome lumen GO:0036021 9.32 CTSB CTSL

Biological processes related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.95 CTGF IL6 PDGFB TGFB1 TIMP1
2 positive regulation of gene expression GO:0010628 9.85 CTGF IL1A IL6 PDGFB TGFB1
3 negative regulation of gene expression GO:0010629 9.81 CD36 CTGF PDGFB TGFB1
4 positive regulation of protein phosphorylation GO:0001934 9.8 CTGF FAM20A TGFB1
5 cytokine-mediated signaling pathway GO:0019221 9.8 DCN IL1A IL6
6 response to organic cyclic compound GO:0014070 9.78 CTGF IL6 TGFB1
7 positive regulation of MAPK cascade GO:0043410 9.73 CD36 IL6 PDGFB
8 platelet degranulation GO:0002576 9.73 CD36 PDGFB TGFB1 TIMP1
9 positive regulation of cell division GO:0051781 9.71 IL1A PDGFB TGFB1
10 wound healing GO:0042060 9.71 DCN IL6 TGFB1 TIMP1
11 toll-like receptor signaling pathway GO:0002224 9.67 CD36 CTSB CTSL
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 CD36 IL6 PDGFB TGFB1
13 positive regulation of interleukin-6 production GO:0032755 9.65 CD36 IL1A IL6
14 positive regulation of vascular endothelial growth factor production GO:0010575 9.64 IL1A TGFB1
15 positive regulation of mitotic nuclear division GO:0045840 9.64 IL1A PDGFB
16 positive regulation of collagen biosynthetic process GO:0032967 9.63 CTGF TGFB1
17 positive regulation of blood vessel endothelial cell migration GO:0043536 9.62 PDGFB TGFB1
18 response to wounding GO:0009611 9.62 CTGF IL6 PDGFB TGFB1
19 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.61 PDGFB TGFB1
20 response to fatty acid GO:0070542 9.6 CD36 CTGF
21 cell activation GO:0001775 9.59 TGFB1 TIMP1
22 cellular response to thyroid hormone stimulus GO:0097067 9.58 CTSB CTSL
23 positive regulation of protein oligomerization GO:0032461 9.58 MMP1 MMP3
24 positive regulation of chemotaxis GO:0050921 9.57 PDGFB TGFB1
25 collagen catabolic process GO:0030574 9.56 CTSB CTSL MMP1 MMP3
26 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.55 CD36 CTGF IL6 PDGFB TGFB1
27 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.52 IL1A TGFB1
28 aging GO:0007568 9.35 CTGF DCN IL6 TGFB1 TIMP1
29 extracellular matrix disassembly GO:0022617 9.02 CTSL DCN MMP1 MMP3 TIMP1

Molecular functions related to Gingival Overgrowth according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 CTSB CTSL MMP1 MMP3
2 cytokine activity GO:0005125 9.46 IL1A IL6 TGFB1 TIMP1
3 fibronectin binding GO:0001968 9.43 CTGF CTSL
4 protein serine/threonine kinase activator activity GO:0043539 9.37 FAM20A TGFB1
5 proteoglycan binding GO:0043394 9.32 CTSB CTSL
6 collagen binding GO:0005518 9.26 CTSB CTSL DCN PDGFB
7 growth factor activity GO:0008083 9.02 CTGF IL6 PDGFB TGFB1 TIMP1
8 protein binding GO:0005515 10.18 CD36 CTGF CTSB CTSL DCN FAM20A

Sources for Gingival Overgrowth

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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