MCID: GNG012
MIFTS: 50

Gingival Overgrowth malady

Gastrointestinal category

Summaries for Gingival Overgrowth

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia or... more...

MalaCards: Gingival Overgrowth, also known as gingival enlargement nos, is related to aggressive periodontitis and fibromatosis, gingival. An important gene associated with Gingival Overgrowth is NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Crosslinking of collagen fibrils. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are integument and respiratory system.

Aliases & Classifications for Gingival Overgrowth

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

gingival overgrowth 8 10 45 61
gingival enlargement nos 8
gingival enlargement 8
gingival hyperplasia 61


External Ids:

Disease Ontology8 DOID:3086
MeSH35 D019214
ICD1025 K06.1

Related Diseases for Gingival Overgrowth

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gingival Overgrowth via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1aggressive periodontitis30.5MMP1, IL1A
2fibromatosis, gingival30.1TGFB1, MMP1, CD36
3keloids30.1TGFB1, MMP1, CD36, DCN, CTGF, LOX
4arthropathy30.1MMP1, MMP3, IL1B, DCN, TIMP1
5acute leukemia10.3
6proteus syndrome10.2
7gingival fibromatosis with hypertrichosis10.2
8juvenile hyaline fibromatosis10.2
9hypertrichosis terminalis, generalized, with or without gingival hyperplasia10.2
10acute myelomonocytic leukemia10.2
11sturge-weber syndrome10.2
12odontogenic myxoma10.2
13bardet-biedl syndrome10.1
14myofibroma10.1
15tuberous sclerosis10.1
16amelogenesis imperfecta10.1
17gingival hypertrophy10.1
18extramedullary plasmacytoma10.1
19behcet's disease10.1
20fibromatosis10.1
21mental retardation epilepsy10.1
22weber syndrome10.1
23mental retardation10.1
24hypertrichosis, congenital generalized10.1
25scalp syndrome10.1
26acute monocytic leukemia10.0
27nocardiosis10.0
28cystinosis10.0
29laband syndrome10.0
30schinzel giedion syndrome10.0
31amelogenesis imperfecta and gingival fibromatosis syndrome10.0
32hypertrichosis universalis congenita10.0
33recombinant 8 syndrome10.0
34neurofibromatosis10.0
35niemann-pick disease10.0
36klippel-trenaunay syndrome10.0
37ossifying fibroma10.0
38acute myeloid leukemia10.0
39myeloid sarcoma10.0
40niemann–pick disease10.0
41cluster headache10.0
42headache10.0
43leukemia, acute myeloid, therapy-related10.0
44moyamoya disease10.0NUDT6
45prostatitis10.0SRD5A1
46hepatitis10.0PDGFB
47retinal detachment10.0PDGFB
48hypertension10.0TGFB1
49hepatitis c10.0CTSB
50coronary heart disease10.0ITGA2

Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to gingival overgrowth

Clinical Features for Gingival Overgrowth

Drugs & Therapeutics for Gingival Overgrowth

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Gingival Overgrowth

Anatomical Context for Gingival Overgrowth

Animal Models for Gingival Overgrowth or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Gingival Overgrowth

Sources:
51PubMed
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Articles related to Gingival Overgrowth:

(show top 50)    (show all 392)
idTitleAuthorsYear
1
Expression of angiotensin II and its receptors in cyclosporine-induced gingival overgrowth. (23106187)
2013
2
Association of CD14-260 polymorphisms, red-complex periodontopathogens and gingival crevicular fluid cytokine levels with cyclosporine A-induced gingival overgrowth in renal transplant patients. (22934794)
2013
3
Laser-Assisted Periodontal Management of Drug-Induced Gingival Overgrowth under General Anesthesia: A Viable Option. (23819068)
2013
4
Interleukin-10 gene promoter polymorphisms are associated with cyclosporin A-induced gingival overgrowth in renal transplant patients. (23643609)
2013
5
Differences in the expression of glycosaminoglycans in human fibroblasts derived from gingival overgrowths is related to TGF-beta up-regulation. (19886734)
2010
6
Klippel-TrAcnaunay syndrome manifesting as gingival overgrowth and teeth agenesis. (20831140)
2010
7
Gingival overgrowth in cyclosporine, tacrolimus, or sirolimus-based immunosuppressive regimens and the single nucleotide IL-6 (-174 G/C) gene polymorphism. (20430366)
2010
8
Full-mouth disinfection as a nonsurgical treatment approach for drug-induced gingival overgrowth: a series of 11 cases. (20224832)
2010
9
Elevation of collagen type I in fibroblast-keratinocyte cocultures emphasizes the decisive role of fibroblasts in the manifestation of the phenotype of cyclosporin A-induced gingival overgrowth. (18973541)
2009
10
Gingival overgrowth in dogs associated with clinically relevant cyclosporine blood levels: observations in a canine renal transplantation model. (18394071)
2008
11
Non-surgical periodontal treatment of cyclosporin A-induced gingival overgrowth: immunohistochemical results. (18266838)
2008
12
Clinical and pharmacological variables as a risk factor for nifedipine-induced gingival overgrowth. (18265685)
2007
13
Endothelin-1 and its receptors ET(A) and ET(B) in drug-induced gingival overgrowth. (17274718)
2007
14
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (16670920)
2006
15
Analysis of proliferative activity in oral gingival epithelium in immunosuppressive medication induced gingival overgrowth. (16712728)
2006
16
Sonic tooth brushing reduces gingival overgrowth in renal transplant recipients. (16937132)
2006
17
Platelet-derived growth factor (PDGF) isoform and PDGF receptor expression in drug-induced gingival overgrowth and hereditary gingival fibrosis. (16700743)
2006
18
Apoptosis in cyclosporin A-induced gingival overgrowth: a histological study. (15974838)
2005
19
Enhancement of nifedipine-induced gingival overgrowth by concomitant ketoconazole in rats. (15677883)
2005
20
Inhibition of cyclosporin A-induced gingival overgrowth by azithromycin through phagocytosis: an in vivo and in vitro study. (15088875)
2004
21
Salivary proteins and cytokines in drug-induced gingival overgrowth. (15044507)
2004
22
Effect of cyclosporin A on human gingival fibroblast collagen turnover in relation to the development of gingival overgrowth: an in vitro study. (15183848)
2004
23
Mechanisms and management of gingival overgrowth in paediatric transplant recipients: a review. (12834381)
2003
24
Immunohistochemical analysis of epidermal growth factor receptor in cyclosporin A-induced gingival overgrowth. (11831486)
2001
25
Oral diagnosis of Behcet disease in an eleven-year old girl and the non-surgical treatment of her gingival overgrowth caused by Cyclosporine. (11688821)
2001
26
Amlodipine-induced gingival overgrowth: periodontal responses to stopping and restarting the drug. (11484582)
2001
27
Tacrolimus is not associated with gingival overgrowth in renal transplant patients. (11493354)
2001
28
Serum phenytoin concentration and IgG antibody titre to periodontal bacteria in patients with phenytoin-induced gingival overgrowth. (12666977)
2001
29
The rA'le of time in reducing gingival overgrowth in heart-transplanted patients following cyclosporin therapy. (10959788)
2000
30
Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results. (10505798)
1999
31
Cyclosporin associated gingival overgrowth in renal transplant recipients. (10218038)
1999
32
Cyclosporine A-induced gingival overgrowth: a comprehensive review. (10765878)
1999
33
Signal recognition particle receptor (SRPR) is downregulated in a rat model of cyclosporin A-induced gingival overgrowth. (10444742)
1999
34
Nifedipine-induced gingival overgrowth in rats: brief review and experimental study. (9706853)
1998
35
Positive correlation between blood cyclosporin A level and severity of gingival overgrowth in rats. (9029445)
1997
36
Nifedipine-associated gingival overgrowth: a survey of the literature and report of four cases. (9063228)
1996
37
Relationship of cyclosporine and gingival overgrowth. (18417769)
1996
38
Case presentation. Initiation of gingival overgrowth by an increased daily dosage of nifedipine. (9569836)
1994
39
The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth. (8421114)
1993
40
Extracellular matrix analysis of nifedipine-induced gingival overgrowth: immunohistochemical distribution of different collagen types as well as the glycoprotein fibronectin. (8426277)
1993
41
Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice. (1424550)
1992
42
Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. (1625155)
1992
43
Regression of phenytoin-induced gingival overgrowth after withdrawal of medication. (1876981)
1991
44
Effect of folic acid on recurrence of phenytoin-induced gingival overgrowth following gingivectomy. (2005227)
1991
45
Diphenylhydantoin-induced gingival overgrowth in man: a clinico-pathological study. (2213467)
1990
46
Gingival overgrowth: hereditary considerations. (2097045)
1990
47
Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. (3477745)
1987
48
Office management of phenytoin-induced gingival overgrowth. (3855742)
1985
49
Phenytoin induced gingival overgrowth in institutionalized epileptics. (6584450)
1984
50
Phenytoin-induced gingival overgrowth control in severely retarded children. (6956708)
1982

Genetic Variations for Gingival Overgrowth

Expression for genes affiliated with Gingival Overgrowth

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gingival Overgrowth

Search GEO for disease gene expression data for Gingival Overgrowth.

Pathways for genes affiliated with Gingival Overgrowth

Sources:
53R&D Systems, 54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore
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Pathways related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL1B
210.4LOX, COL1A1
310.4IL1B, IL1A
4
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10.4CD36, TIMP1
5
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10.3NUDT6, PDGFB, TIMP4
610.3FGF7, DCN, ITGA2
710.3TGFB1, IL1B, IL1A
810.3COL1A1, ITGA2, CD36
9
Immune response Bacterial infections in normal airways
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10.3CTSB, IL1A, IL1B
10
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.3IL1B, IL1A, COL1A1
11
Cell adhesion ECM remodeling
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10.3COL1A1, TIMP1, MMP3, MMP1
12
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10.2COL1A1, TIMP1, CTSB, MMP3
13
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10.2TIMP4, TIMP1, MMP3, MMP1
1410.2ITGA2, CD36, IL1A, IL1B
15
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10.2TIMP1, PDGFB, CTGF, NUDT6, FGF7
1610.2PDGFB, ITGA2, FGF7, MMP1, TGFB1
17
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10.2CD36, DCN, ITGA2, PDGFB, COL1A1
18
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10.2TIMP4, PDGFB, CTGF, NUDT6, FGF7
19
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10.2COL1A1, ITGA2, CD36, MMP3, MMP1
20
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10.2CD36, ITGA2, PDGFB, TIMP1, COL1A1
21
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10.2PDGFB, FGF7, IL1A, IL1B, TGFB1
22
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10.2TIMP1, PDGFB, CTGF, NUDT6, FGF7, TGFB1
23
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10.1IL1B, IL1A, FGF7, CD36, CTSB, PDGFB
24
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10.1COL1A1, TIMP4, PDGFB, CTGF, ITGA2, NUDT6
25
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10.1TIMP4, TIMP1, PDGFB, CTGF, NUDT6, FGF7
26
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10.1IL1B, TIMP4, TIMP1, PDGFB, CTGF, NUDT6
27
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10.0COL1A1, TIMP4, TIMP1, PDGFB, CTGF, ITGA2
28
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10.0LOX, COL1A1, TIMP1, PDGFB, CTSB, ITGA2
29
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10.0TIMP4, TIMP1, PDGFB, CTGF, ITGA2, NUDT6
30
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9.9CTGF, PDGFB, TIMP1, TIMP4, ITGA2, NUDT6
31
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9.9CTGF, PDGFB, TIMP1, TIMP4, ITGA2, NUDT6
32
Hide members
9.9TIMP4, TIMP1, PDGFB, CTGF, ITGA2, NUDT6

Compounds for genes affiliated with Gingival Overgrowth

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1procollagen4510.9TGFB1
2estrogen4510.9SRD5A1
3pge24510.8TGFB1, COL1A1
4cycloheximide4510.8PDGFB, FGF7
5alginate4510.7DCN, CD36
6indomethacin45 60 29 1113.7LOX, CTSB, SRD5A1
7hydrocortisone45 2 60 1113.6HAS3, MMP1
8cyclosporin a45 29 6012.6DCN, CTSB, MMP1, FGF7, PDGFB, CTGF
9uva 14510.6MMP3, MMP1, TIMP1, IL1A
10doxycycline45 1111.6DSPP, NUDT6, MMP1, FGF7, MMP3
11(4-aminophenyl)mercuric acetate4510.6MMP3, TIMP1
12prostaglandin4510.5MMP3, LOX, IL1A, MMP1, IL1B
13matrigel4510.5CTSB, LOX, ITGA2, DCN, NUDT6, MMP1
14minocycline45 1111.5IL1A, SRD5A1, IL1B, TIMP1, DSPP
15rantes4510.5IL1A, IL1B, TGFB1, FGF7
16alendronate45 50 1112.5TIMP1, DSPP, MMP1, MMP3, CD36
17vitamin d4510.5COL1A1, CD36, FGF7, MMP3, SRD5A1, DSPP
18ns 39845 6011.5MMP1, IL1B, IL1A, LOX, TGFB1
19bleomycin45 1111.5LOX, COL1A1, TIMP1, PDGFB, CTGF, TGFB1
20hydroxyproline45 11 2412.5TGFB1, LOX, COL1A1, TIMP1, CTGF, CTSB
21dexamethasone45 50 29 1113.4HAS3, PDGFB, TIMP1, COL1A1, LOX, CTGF
22curcumin4510.4TGFB1, MMP1, MMP3, IL1B, IL1A, TIMP1
23sb 20358045 6011.4TGFB1, TIMP1, CTGF, CD36, IL1A, IL1B
24lactate4510.4MMP1, MMP3, TGFB1, CTGF, TIMP1, LOX
25calcitriol45 60 11 2413.4MMP1, IL1B, IL1A, CD36, TIMP1, TGFB1
26pd 98,0594510.4MMP3, TGFB1, MMP1, IL1B, FGF7, NUDT6
27polyglycolic acid4510.4FGF7, DSPP, PDGFB
28tgf beta14510.4MMP1, FGF7, CD36, DCN, CTGF, PDGFB
29paraffin4510.4PDGFB, CTSB, DCN, DSPP, MMP3, MMP1
30serine4510.4FGF7, TGFB1, MMP3, TIMP1, PDGFB, CTGF
31cytochalasin d45 6011.3CD36, MMP3, MMP1, TGFB1, TIMP1, CTGF
32nitric oxide45 11 2412.3TIMP1, CTGF, IL1A, PDGFB, CTSB, ITGA2
33thymidine45 2411.3LOX, FGF7, TGFB1, IL1B, IL1A, CTGF
34hyaluronic acid45 2411.3TGFB1, MMP1, MMP3, IL1B, IL1A, FGF7
35heparin45 29 11 2413.3CD36, CTGF, DCN, CTSB, ITGA2, FGF7
36genistein45 29 60 2 11 2415.3TIMP1, DCN, CD36, IL1B, MMP3, MMP1
3712-o-tetradecanoylphorbol 13-acetate4510.3MMP3, TIMP1, ITGA2, FGF7, IL1A, MMP1
38aspartate4510.3FGF7, COL1A1, DCN, DSPP, IL1A
39ribonucleic acid4510.3COL1A1, TIMP1, PDGFB, TGFB1, MMP1, MMP3
40glycosaminoglycan4510.3TGFB1, MMP1, MMP3, IL1A, FGF7, CD36
41h2o24510.3CD36, FGF7, IL1A, MMP1, DSPP, CTSB
42creatinine4510.3CD36, IL1A, TGFB1, DCN, CTSB, MMP3
43glutamine4510.3CTSB, TIMP1, TGFB1, SRD5A1, FGF7, CD36
44cysteine4510.2LOX, COL1A1, TIMP1, CTGF, CTSB, ITGA2
45glyceraldehyde 3-phosphate4510.2MMP1, TIMP1, CTGF, CTSB, DCN, MMP3
46carbon4510.2LOX, CTSB, MMP1, DSPP, ITGA2, TIMP1
47pirfenidone45 6011.1IL1B, CD36, IL1A, TGFB1
48vegf4510.0TGFB1, SRD5A1, MMP1, MMP3, IL1B, LOX
49retinoic acid45 2411.0MMP3, MMP1, SRD5A1, IL1B, IL1A, FGF7
50prostacyclin459.9CTGF, IL1A, IL1B, PDGFB, TIMP1, LOX

GO Terms for genes affiliated with Gingival Overgrowth

Sources:
16Gene Ontology
See all sources

Cellular components related to Gingival Overgrowth according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3TGFB1, PDGFB, TIMP1
2proteinaceous extracellular matrixGO:0055789.9CTGF, DSPP, MMP3, MMP1, TGFB1
3extracellular spaceGO:0056159.8LOX, COL1A1, TIMP4, PDGFB, CTGF, CTSB
4extracellular regionGO:0055769.7TGFB1, LOX, COL1A1, TIMP4, TIMP1, PDGFB

Biological processes related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.6IL1B, IL1A
2response to woundingGO:00961110.6PDGFB, CTGF, FGF7, TGFB1
3positive regulation vascular endothelial growth factor productionGO:01057510.6TGFB1, IL1B, IL1A
4positive regulation of mitosisGO:04584010.6PDGFB, IL1A, IL1B
5collagen catabolic processGO:03057410.6MMP1, MMP3, CTSB, COL1A1
6extracellular matrix assemblyGO:08502910.6HAS3, TGFB1
7response to peptide hormone stimulusGO:04343410.6COL1A1, TIMP4, TIMP1, CTGF
8platelet degranulationGO:00257610.6TIMP1, PDGFB, CD36, TGFB1
9extracellular matrix disassemblyGO:02261710.5MMP1, MMP3, CTSB, TIMP1, COL1A1
10positive regulation of cell divisionGO:05178110.5PDGFB, FGF7, IL1A, IL1B, TGFB1
11hyaluronan biosynthetic processGO:03021310.5HAS3, IL1B
12response to estradiol stimulusGO:03235510.5TGFB1, CTGF, PDGFB
13platelet activationGO:03016810.5COL1A1, TIMP1, PDGFB, CD36, TGFB1
14positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5PDGFB, CD36, FGF7
15positive regulation of chemotaxisGO:05092110.4TGFB1, PDGFB
16positive regulation of cell proliferationGO:00828410.4TIMP1, PDGFB, CTGF, FGF7, TGFB1
17blood coagulationGO:00759610.4COL1A1, TIMP1, PDGFB, ITGA2, CD36, MMP1
18positive regulation of protein phosphorylationGO:00193410.3CTGF, IL1B, TGFB1
19extracellular matrix organizationGO:03019810.3TGFB1, LOX, COL1A1, TIMP1, PDGFB, CTSB
20agingGO:00756810.3TGFB1, DCN, TIMP1
21positive regulation of transcription, DNA-dependentGO:04589310.3TGFB1, IL1B, HAS3, PDGFB, COL1A1
22response to drugGO:04249310.2TGFB1, PDGFB, TIMP4, LOX
23branching involved in salivary gland morphogenesisGO:06044510.1PDGFB, FGF7

Molecular functions related to Gingival Overgrowth according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.4PDGFB, COL1A1
2collagen bindingGO:00551810.2DSPP, DCN, ITGA2, PDGFB
3growth factor activityGO:0080839.9PDGFB, CTGF, NUDT6, FGF7, TGFB1

Products for genes affiliated with Gingival Overgrowth

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Sources for Gingival Overgrowth

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet