MCID: GNG012
MIFTS: 52

Gingival Overgrowth malady

Gastrointestinal diseases, Oral diseases categories
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Summaries for Gingival Overgrowth

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Wikipedia:65 Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia or... more...

MalaCards based summary: Gingival Overgrowth, also known as gingival enlargement nos, is related to periodontitis and arthropathy. An important gene associated with Gingival Overgrowth is NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6), and among its related pathways are Non-integrin membrane-ECM interactions and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds grgdsp and geranylgeranyl pyrophosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Gingival Overgrowth

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 25ICD10
See all sources

Gingival Overgrowth, Aliases & Descriptions:

Name: Gingival Overgrowth 8 10 44 62
Gingival Enlargement Nos 8
 
Gingival Enlargement 8
Gingival Hyperplasia 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


External Ids:

Disease Ontology8 DOID:3086
MeSH34 D019214
ICD1025 K06.1

Related Diseases for Gingival Overgrowth

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Diseases related to Gingival Overgrowth via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.3CTSB, MMP1
2arthropathy30.3DCN, MMP1
3keloids29.9DCN, CTGF, LOX, MMP1
4gingivitis11.4
5aggressive periodontitis10.4
6endotheliitis10.4
7proliferative vitreoretinopathy10.3CTGF, NUDT6
8leukemia10.3
9hypertrichosis10.3
10renal fibrosis10.3CTGF, PDGFB
11sturge-weber syndrome10.2
12abdominal aortic aneurysm10.2MMP1, DCN
13myopia 610.2NUDT6, DCN
14oral submucous fibrosis10.2LOX, MMP1
15connective tissue disease10.1LOX, CTGF
16marfan syndrome10.1DCN, LOX
17nephritis10.1PDGFB, CTGF
18idiopathic pulmonary fibrosis10.1PDGFB, MMP1, CTGF
19amelogenesis imperfecta10.1
20cerebral palsy10.1
21hemolytic anemia10.1
22hodgkin's lymphoma10.1
23bardet-biedl syndrome10.1
24tuberous sclerosis10.1
25fibroma10.1
26gingival hypertrophy10.1
27cerebritis10.1
28extramedullary plasmacytoma10.1
29cervicitis10.1
30hyperglycemia10.1
31plasmacytoma10.1
32pneumonia10.1
33fibromatosis10.1
34weber syndrome10.1
35mental retardation10.1
36fibromatosis, gingival10.1
37amelogenesis imperfecta, type ig10.1
38glomerulosclerosis10.1DCN, CTGF
39cutaneous fibrous histiocytoma10.1PDGFB, CTSB
40bladder carcinoma10.1NUDT6, ITGA2, PDGFB
41diabetic retinopathy10.1PDGFB, CTGF, ITGA2
42glomerulonephritis10.1CTGF, PDGFB, DCN
43rhabdomyosarcoma10.1PDGFB, CTGF, ITGA2
44diabetic nephropathy10.1DCN, CTGF, PDGFB
45brain cancer10.1DCN, PDGFB, NUDT6
46chondrosarcoma10.1CTGF, MMP1, ITGA2
47berger disease10.1PDGFB, DCN
48acute myeloid leukemia10.1
49chronic lymphocytic leukemia10.1
50niemann-pick disease10.1

Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to gingival overgrowth

Symptoms for Gingival Overgrowth

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Drugs & Therapeutics for Gingival Overgrowth

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Drug clinical trials:

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Search NIH Clinical Center for Gingival Overgrowth

Genetic Tests for Gingival Overgrowth

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Anatomical Context for Gingival Overgrowth

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MalaCards organs/tissues related to Gingival Overgrowth:

32
Heart, Kidney, Liver, Endothelial, Bone marrow, Bone, Lung

Animal Models for Gingival Overgrowth or affiliated genes

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MGI Mouse Phenotypes related to Gingival Overgrowth:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5CTGF, PDGFB, LOX, DCN
2MP:00107717.1CTGF, CTSB, PDGFB, ITGA2, LOX, DCN
3MP:00053766.4DCN, MMP1, LOX, ITGA2, PDGFB, CTSB

Publications for Gingival Overgrowth

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Articles related to Gingival Overgrowth:

(show top 50)    (show all 394)
idTitleAuthorsYear
1
Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth. (24581850)
2014
2
Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth. (23803025)
2013
3
Can chlorhexidine mouthwash twice daily ameliorate cyclosporine-induced gingival overgrowth? (23473525)
2013
4
Serum cyclophilin A concentrations in renal transplant recipients receiving cyclosporine A: clinical implications for gingival overgrowth. (24035111)
2013
5
Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts. (21883230)
2012
6
Loss of basement membrane integrity in human gingival overgrowth. (21483030)
2011
7
Gingival overgrowth and drug association: a review. (23196317)
2011
8
Surgical management of gingival overgrowth associated with Cowden sydrome: a case report and current understanding. (21519553)
2011
9
Gingival overgrowth secondary to amlodipine. (19749649)
2009
10
Gingival overgrowth in a renal transplant recipient using cyclosporine A. (19040821)
2008
11
Local inflammation exacerbates cyclosporine a-induced gingival overgrowth in rats. (18982435)
2008
12
Expression of fibronectin-binding integrins in gingival epithelium in drug-induced gingival overgrowth. (17305873)
2007
13
Apoptosis and expression of caspase-3 in cyclosporin-induced gingival overgrowth. (18052710)
2007
14
Clinical and pharmacological variables as a risk factor for nifedipine-induced gingival overgrowth. (18265685)
2007
15
The role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowth. (17989122)
2007
16
Apoptosis in gingival overgrowth tissues. (17720861)
2007
17
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (16670920)
2006
18
Elevated levels of gene expression for collagen and decorin in human gingival overgrowth. (16820039)
2006
19
Gingival overgrowth in renal transplant recipients induced by pharmacological treatment. Review of the literature. (16495873)
2006
20
Increased expression of vascular endothelial growth factor in cyclosporin A-induced gingival overgrowth in rats. (16579703)
2006
21
Apoptosis in cyclosporin A-induced gingival overgrowth: a histological study. (15974838)
2005
22
Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. (15732868)
2004
23
Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin A therapy. (15341348)
2004
24
CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects. (14659971)
2004
25
Connective tissue metabolism and gingival overgrowth. (15187034)
2004
26
Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. (12828653)
2003
27
The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients. (12662462)
2003
28
Cytomegalovirus and cyclosporin-induced gingival overgrowth in children with liver grafts. (12121533)
2002
29
Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1. (12378028)
2002
30
Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation. (12452980)
2002
31
Incidence of phenytoin induced gingival overgrowth in epileptic children: a six month evaluation. (12435021)
2002
32
Immunohistochemical analysis of epidermal growth factor receptor in cyclosporin A-induced gingival overgrowth. (11831486)
2001
33
Upregulation of keratinocyte growth factor in cyclosporin A-induced gingival overgrowth. (11453236)
2001
34
Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. (10052772)
1999
35
Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy. (9667479)
1998
36
Human papillomavirus in a patient with severe gingival overgrowth associated with cyclosporine therapy. A case report. (8724712)
1996
37
Nifedipine-associated gingival overgrowth: a survey of the literature and report of four cases. (9063228)
1996
38
Iatrogenic gingival overgrowth in cardiac transplantation. (7473018)
1995
39
Gingival overgrowth in paediatric cardiac transplant patients: a study of 19 patients aged between 2 and 16 years. (8957834)
1995
40
Dose-dependent gingival overgrowth induced by cyclosporin in rats. (7562351)
1995
41
Altered collagen metabolism in nifedipine-induced gingival overgrowth. (7877076)
1994
42
Periodontal management of nifedipine-induced gingival overgrowth: a case report and review of the pertinent literature. (8779668)
1994
43
Immunohistochemical study of 30 cases of cyclosporin A-induced gingival overgrowth. (7608852)
1994
44
Effect of periodontal treatment on gingival overgrowth among cyclosporine A-treated renal transplant recipients. (8295099)
1993
45
Gingival overgrowth among renal transplant recipients and uraemic patients. (8302465)
1993
46
The incidence and severity of nifedipine-induced gingival overgrowth. (1517474)
1992
47
Phenytoin-induced gingival overgrowth in rats infected with Streptococcus sobrinus 6715. (2151111)
1990
48
The reduction of phenytoin-induced gingival overgrowth in a severely disabled patient: a case report. (2605605)
1989
49
Cyclosporine-induced gingival overgrowth: an ultrastructural stereologic study. (3422723)
1988
50
Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. (3477745)
1987

Variations for Gingival Overgrowth

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Expression for genes affiliated with Gingival Overgrowth

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Expression patterns in normal tissues for genes affiliated with Gingival Overgrowth

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Pathways for genes affiliated with Gingival Overgrowth

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Pathways related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Proteogylcan syndecan-mediated signaling events37
9.5PDGFB, ITGA2
29.5MMP1, DCN
39.4ITGA2, DCN
49.4ITGA2, DCN
5
Show member pathways
9.3NUDT6, PDGFB, CTGF
6
Show member pathways
9.3NUDT6, PDGFB, CTGF
7
Show member pathways
9.3NUDT6, PDGFB, CTGF
8
Show member pathways
9.3NUDT6, PDGFB, CTGF
9
Show member pathways
9.2NUDT6, ITGA2, PDGFB
10
Show member pathways
9.1PDGFB, ITGA2, MMP1
119.1MMP1, ITGA2, PDGFB
12
Show member pathways
8.8NUDT6, ITGA2, PDGFB, CTGF
13
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
14
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
15
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
16
Show member pathways
8.4NUDT6, MMP1, ITGA2, PDGFB, CTGF
17
Show member pathways
7.1CTSB, PDGFB, ITGA2, LOX, MMP1, DCN

Compounds for genes affiliated with Gingival Overgrowth

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Compounds related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1grgdsp449.8ITGA2, MMP1
2geranylgeranyl pyrophosphate449.7MMP1, CTGF
3agar449.5NUDT6, PDGFB, CTGF
4quinacrine44 1110.4LOX, MMP1
5alpha tocopherol449.4CTGF, LOX, MMP1
6prostacyclin449.4CTGF, PDGFB, LOX
7curcumin449.3MMP1, LOX, CTGF
812-hydroxyeicosatetraenoic acid449.3LOX, CTSB
9sodium dodecylsulfate449.3ITGA2, MMP1, DCN
10nacl449.3DCN, ITGA2, CTGF
11prostaglandin449.3MMP1, LOX, CTGF
12pyridoxal44 24 1111.3CTSB, LOX
13glycosaminoglycan449.2DCN, MMP1, LOX
14aspirin44 50 28 2412.1ITGA2, LOX, MMP1
15tgf beta1449.1DCN, MMP1, PDGFB, CTGF
16n acetylcysteine449.0CTGF, LOX, MMP1
17oligonucleotide449.0CTGF, PDGFB, MMP1, DCN
18bleomycin44 1110.0CTGF, PDGFB, LOX, DCN
19ribonucleic acid448.8NUDT6, DCN, MMP1, PDGFB, CTGF
20pd 98,059448.8NUDT6, DCN, MMP1, PDGFB, CTGF
21polyacrylamide448.8DCN, ITGA2, CTSB
22glyceraldehyde 3-phosphate448.7DCN, MMP1, CTSB, CTGF
23creatinine448.7DCN, MMP1, CTSB, CTGF
24heparin44 28 24 1111.6CTGF, CTSB, ITGA2, DCN
25procollagen448.5DCN, MMP1, LOX, PDGFB, CTGF
26h2o2448.5MMP1, LOX, CTSB, CTGF
27arginine448.5NUDT6, DCN, ITGA2, CTSB
28indomethacin44 28 61 1111.5MMP1, LOX, CTSB
29zinc44 249.5DCN, MMP1, PDGFB, CTSB
30fibrinogen448.5CTGF, CTSB, ITGA2
31carbon448.4CTSB, ITGA2, LOX, MMP1
32glutamate448.4CTSB, ITGA2, DCN, NUDT6
33cyclosporin a44 28 6110.3DCN, MMP1, PDGFB, CTSB, CTGF
34thymidine44 249.3NUDT6, LOX, PDGFB, CTSB, CTGF
35lactate448.3CTGF, CTSB, LOX, MMP1, NUDT6
36hydroxyproline44 24 1110.1DCN, MMP1, LOX, CTSB, CTGF
37pge2448.1DCN, MMP1, LOX, CTSB, CTGF
38paraffin448.1DCN, MMP1, LOX, PDGFB, CTSB
39serine447.9NUDT6, DCN, MMP1, PDGFB, CTSB, CTGF
40nitric oxide44 24 119.9NUDT6, DCN, ITGA2, PDGFB, CTSB, CTGF
41cycloheximide447.7MMP1, LOX, ITGA2, PDGFB, CTSB, CTGF
42dexamethasone44 50 28 1110.7DCN, MMP1, LOX, PDGFB, CTSB, CTGF
43estrogen447.7DCN, MMP1, LOX, PDGFB, CTSB, CTGF
44matrigel447.6NUDT6, DCN, MMP1, LOX, ITGA2, CTSB
45oxygen44 248.6DCN, LOX, ITGA2, PDGFB, CTSB, CTGF
46glucose447.3NUDT6, DCN, LOX, ITGA2, PDGFB, CTSB
47tyrosine447.3NUDT6, DCN, LOX, ITGA2, PDGFB, CTSB
48retinoic acid44 248.3NUDT6, DCN, MMP1, LOX, ITGA2, CTSB
49cysteine447.3NUDT6, DCN, MMP1, LOX, ITGA2, CTSB
50vegf446.9CTGF, NUDT6, DCN, MMP1, LOX, ITGA2

GO Terms for genes affiliated with Gingival Overgrowth

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Cellular components related to Gingival Overgrowth according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484718.8CTGF, CTSB, ITGA2
2extracellular spaceGO:0056157.4DCN, LOX, PDGFB, CTSB, CTGF
3extracellular regionGO:0055767.2CTGF, CTSB, PDGFB, LOX, MMP1, DCN

Biological processes related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1reactive oxygen species metabolic processGO:0725939.9CTGF, PDGFB
2response to woundingGO:0096119.9CTGF, PDGFB
3positive regulation of collagen biosynthetic processGO:0329679.8CTGF, ITGA2
4positive regulation of smooth muscle cell migrationGO:0149119.8ITGA2, PDGFB
5positive regulation of smooth muscle cell proliferationGO:0486619.7ITGA2, PDGFB
6integrin-mediated signaling pathwayGO:0072299.6ITGA2, CTGF
7cell-matrix adhesionGO:0071609.6CTGF, ITGA2
8wound healingGO:0420609.5LOX, DCN
9lung developmentGO:0303249.5CTGF, LOX
10response to estradiolGO:0323559.4CTGF, PDGFB
11blood coagulationGO:0075969.2PDGFB, ITGA2, MMP1
12response to drugGO:0424939.1PDGFB, ITGA2, LOX
13collagen catabolic processGO:0305749.1CTSB, MMP1
14extracellular matrix disassemblyGO:0226179.0CTSB, MMP1, DCN
15extracellular matrix organizationGO:0301987.4CTSB, DCN, MMP1, LOX, ITGA2, PDGFB

Molecular functions related to Gingival Overgrowth according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3CTGF, PDGFB, NUDT6
2collagen bindingGO:0055187.9CTSB, PDGFB, ITGA2, DCN

Products for genes affiliated with Gingival Overgrowth

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Sources for Gingival Overgrowth

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet