MCID: GNG012
MIFTS: 42

Gingival Overgrowth malady

Gastrointestinal diseases, Oral diseases categories

Aliases & Classifications for Gingival Overgrowth

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 36MeSH, 65UMLS, 59SNOMED-CT, 27ICD10
See all sources

Aliases & Descriptions for Gingival Overgrowth:

Name: Gingival Overgrowth 10 47 12 36
Gingival Hyperplasia 65 47
 
Gingival Enlargement Nos 10
Gingival Enlargement 10


Classifications:



External Ids:

Disease Ontology10 DOID:3086
MeSH36 D019214
ICD1027 K06.1

Summaries for Gingival Overgrowth

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Wikipedia:68 Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia,... more...

MalaCards based summary: Gingival Overgrowth, also known as gingival hyperplasia, is related to periodontitis and fibromatosis, gingival, 1. An important gene associated with Gingival Overgrowth is MMP1 (Matrix Metallopeptidase 1), and among its related pathways are Immune response_Oncostatin M signaling via JAK-Stat in human cells and Matrix Metalloproteinases. Affiliated tissues include heart, bone and kidney, and related mouse phenotypes are respiratory system and skeleton.

Related Diseases for Gingival Overgrowth

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Diseases related to Gingival Overgrowth via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.1IL1A, IL6, MMP1, TIMP1
2fibromatosis, gingival, 130.7CD36, MMP1, TGFB1
3gingivitis29.6CD36, CTGF, CTSB, CTSL, DCN, IL1A
4leukemia10.4
5aggressive periodontitis10.4
6amelogenesis imperfecta, type ig10.4
7hypertrichosis10.4
8periodontal disease10.4
9endotheliitis10.4
10amelogenesis imperfecta-gingival hyperplasia syndrome10.3
11larynx sarcoma10.3IL6, TGFB1
12miliaria rubra10.3CTGF, TGFB1
13hyaline fibromatosis syndrome10.3
14raine syndrome10.3
15robinow syndrome, autosomal recessive10.3
16lathosterolosis10.3
17multicentric osteolysis, nodulosis, and arthropathy10.3
18marshall-smith syndrome10.3
19mannosidosis, alpha-, types i and ii10.3
20gingival disease10.3
21mouth disease10.3
22fibromatosis10.3
23posterior valve urethra10.3IL6, TGFB1
24vesicoureteral reflux10.3CTGF, TGFB1
25thrombocytopenia due to platelet alloimmunization10.3CTGF, TGFB1
26angina pectoris10.2DCN, MMP1
27diabetic neuropathy10.2PDGFB, TGFB1
28interstitial lung disease10.2CD36, DCN
29odontogenic myxoma10.2
30preterm premature rupture of the membranes10.2IL6, MMP1
31hepatic angiomyolipoma10.2IL6, TIMP1
32keratoconus10.2CD36, MMP1, TGFB1
33ocular melanoma10.2CD36, CTGF, TGFB1
34congenital methemoglobinemia10.2MMP1, PDGFB
35extrahepatic biliary papillomatosis10.2CD36, CTGF, TGFB1
36clonorchiasis10.2IL6, TGFB1, TIMP1
37superior semicircular canal dehiscence syndrome10.2MMP1, MMP3
38odontoma10.1CD36, DCN, MMP1
39chronic ulcer of skin10.1CD36, TGFB1, TIMP1
40ectopia lentis, familial10.1CD36, DCN, TGFB1
41juxtacortical chondroma10.1CTGF, TGFB1, TIMP1
42retinal drusen10.1MMP1, MMP3
43vitreoretinopathy, neovascular inflammatory10.1CTGF, TGFB1, TIMP1
44vulva adenocarcinoma10.1CTGF, PDGFB, TGFB1
45familial isolated hypoparathyroidism due to impaired pth secretion10.1NUDT6, PDGFB
46robinow syndrome, autosomal dominant 210.1
47craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome10.1
48zimmermann-laband syndrome 110.1
49pelger-huet anomaly10.1
50ehlers-danlos syndrome, type iv10.1

Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to gingival overgrowth

Symptoms for Gingival Overgrowth

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Drugs & Therapeutics for Gingival Overgrowth

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Drugs for Gingival Overgrowth (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PhenytoinapprovedPhase 37057-41-01775
Synonyms:
125-59-7
2,4-Imidazolidinedione, 5,5-diphenyl- (9CI)
2-hydroxy-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one
5,5-DIPHENYLHYDANTOIN
5,5-Diphenyl-2,4-imidazolidinedione
5,5-Diphenyl-imidazolidine-2,4-dione
5,5-Diphenylhydantoin
5,5-Diphenylhydantoin (IUPAC)
5,5-Diphenylhydantoin (phenytoin)
5,5-Diphenylimidazolidin-2,4-dione
5,5-Diphenyltetrahydro-1H-2,4-imidazoledione
5,5-Dwufenylohydantoina
5,5-Dwufenylohydantoina [Polish]
5,5-diphenylhydantoin
5,5-diphenylimidazolidine-2,4-dione
5,5-diphenyltetrahydro-1H-2,4-imidazoledione
57-41-0
630-93-3
AC-376
AC1L1C7L
AC1Q6G55
AC1Q6G56
AI3-52498
AKOS000416887
AKOS003245432
Aleviatin
Antisacer
Auranile
BAS 00281572
BIDD:GT0625
BIDD:PXR0090
BRD-K55930204-001-02-7
BSPBio_001437
Bio-0370
C07443
CCRIS 515
CHEBI:8107
CHEMBL16
CID1775
CL12003
Causoin
Citrullamon
Citrulliamon
Comital
Comitoina
Convul
D 4007
D00512
D0894
D4007_SIGMA
DB00252
DILANTIN
DILANTIN-30
DPH
DPH (VAN)
Danten
Dantinal
Dantoinal
Dantoinal klinos
Dantoine
Denyl
Di-Hydan
Di-Lan
Di-Lan (VAN)
Di-Phetine
Didan TDC 250
Didan-tdc-250
Difenilhidantoina
Difenilhidantoina [Spanish]
Difenin
Difetoin
Difhydan
Dihycon
Dihydan toin
Dihydantoin
Dilabid
Dilantin
Dilantin (TN)
Dilantin Infatabs
Dilantin acid
Dilantin-125
Dilantine
Dillantin
Dintoin
Dintoina
Diphantoin
Diphedal
Diphedan
Diphenat
Diphenin
Diphenine
Diphentoin
Diphentyn
Diphenylan
Diphenylan Sodium
Diphenylhydantoin
Diphenylhydantoin (VAN)
Diphenylhydantoine
Diphenylhydantoine [French]
Diphenylhydatanoin
Ditoinate
DivK1c_000507
EINECS 200-328-6
EU-0100378
Ekko
Ekko capsules
Elepsindon
Enkelfel
Epamin
Epanutin
Epasmir "5"
Epasmir 5
Epdantoin Simple
Epdantoine simple
Epelin
Epifenyl
Epihydan
Epilan
Epilan D
Epilan-D
Epilantin
Epinat
Epised
Eptal
Eptoin
Extended Phenytoin Sodium
Fenantoin
Fenantoin Mn Pharma
Fenidantoin "s"
Fenidantoin s
Fenitoin
Fenitoina
Fenitoina [INN-Spanish]
Fentoin
Fenylepsin
Fenytoin Dak
Fenytoine
Gerot-epilan-D
HMS1412J16
HMS1694O05
 
HMS1791H19
HMS1989H19
HMS2089E11
Hidan
Hidantal
Hidantilo
Hidantina
Hidantina senosian
Hidantina vitoria
Hidantomin
Hindatal
Hydantal
Hydantin
Hydantoin
Hydantoin, 5,5-diphenyl- (8CI)
Hydantoinal
Hydantol
I14-6452
IDI1_000507
IDI1_008433
IFLab1_000214
Ictalis simple
Idantoil
Idantoin
InChI=1/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19
Iphenylhydantoin
KBio1_000507
KBio2_001585
KBio2_004153
KBio2_006721
KBio3_001780
KBioGR_001387
KBioSS_001585
Kessodanten
LS-34
Labopal
Lehydan
Lepitoin
Lepsin
Lopac-D-4007
Lopac0_000329
Lopac0_000378
MLS000069789
MLS001074087
MLS002454401
Mesantoin
Minetoin
MolPort-001-785-683
MolPort-002-365-712
MolPort-004-876-351
NCGC00015342-01
NCGC00015342-02
NCGC00015342-04
NCGC00021139-01
NCGC00091492-01
NCGC00091492-02
NCGC00091492-03
NCGC00091492-04
NCGC00091492-05
NCGC00093810-01
NCGC00093810-02
NCI-C55765
NINDS_000507
NSC 8722
NSC8722
Neos-Hidantoina
Neosidantoina
Novantoina
Novophenytoin
Om hidantoina simple
Om-Hydantoine
Oprea1_373280
Oxylan
PHENTYTOIN
PHENYTEK
PHENYTOIN (5,5-DIPHENYLHYDANTOIN)
PHENYTOIN SODIUM, EXTENDED
Phanantin
Phanatine
Phenatine
Phenatoine
Phenhydan
Phenhydanin
Phenitoin
Phentoin
Phentytoin
Phenytek
Phenytex
Phenytoin
Phenytoin (JP15/USP/INN)
Phenytoin AWD
Phenytoin Infatabs
Phenytoin Sodium
Phenytoin [USAN:INN:BAN:JAN]
Phenytoin-Gerot
Phenytoine
Phenytoine [INN-French]
Phenytoinum
Phenytoinum [INN-Latin]
Prompt Phenytoin Sodium
Ritmenal
SMR000059026
SPBio_001281
STK058029
STK182871
Saceril
Sanepil
Silantin
Sinergina
Sodanthon
Sodantoin
Sodanton
Sodium Diphenylhydantoinate
Solantin
Solantoin
Solantyl
Spectrum2_001281
Spectrum3_000890
Spectrum4_000984
Spectrum5_001369
Spectrum_001105
Sylantoic
TOIN
Tacosal
Thilophenyl
Toin unicelles
UNII-6158TKW0C5
WLN: T5MVMV EHJ ER& ER
ZINC02510358
ZINC18140189
Zentronal
Zentropil
component of Mebroin
elepsi ndon
epasmir ''5''
fen toin
fenidantoin ''s''
ictalis simp le
phenat ine
phenytoin
phenytoin (PHN)
taco sal
2
Folic Acidapproved, nutraceuticalPhase 3285159-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
3Vitamin B ComplexPhase 32775
4Folinic AcidNutraceuticalPhase 32498
5Vitamin B9NutraceuticalPhase 32851
6FolateNutraceuticalPhase 32851
7
Tacrolimusapproved, investigational992104987-11-3445643, 439492, 445647, 439492, 445647
Synonyms:
(-)-FK 506
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
104987-11-3
109581-93-3 (Hydrate)
15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,
3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
8-DEETHYL-8-[but-3-enyl]-ascomycin
AC-1182
AC1L1K7H
AC1L97GB
AC1L9IBU
AKOS005145901
Advagraf
Ambap104987-11-3
Ambap5429
BCBcMAP01_000194
BRD-K35452788-001-02-1
BSPBio-001279
BSPBio_001279
Bio-0921
Bio2_000470
Bio2_000950
C01375
C44H69NO10
CCRIS 7124
CHEBI:100924
CHEBI:61049
CHEMBL1200738
CID11158639
CID11556866
CID439492
CID445643
CID5372
CID5472317
CID6426916
CID6436007
CID6473866
CID6536850
CID6610362
CID6912836
CID9832283
CID9853905
CID9918805
CID9940643
CID9963169
CPD-10016
CPD000466356
D08556
DB00864
DivK1c_001040
FK 506
FK-506
FK5
FK506
FR 900506
FR-900506
FR900506
 
FT-0082660
Fk-506
Fujimycin
Graceptor
HMS1362O21
HMS1792O21
HMS1990O21
HMS2051C18
HMS2093M19
HMS503O21
Hecoria
IDI1_001040
IDI1_002225
K506
KBio1_001040
KBio2_000619
KBio2_003187
KBio2_005755
KBio3_001097
KBio3_001098
KBioGR_000619
KBioSS_000619
L 679934
L-679934
LCP-Tacro
LMPK04000003
LS-64247
MLS000759471
MLS001424054
Modigraf
MolPort-003-666-518
NCGC00163470-01
NCGC00163470-02
NCGC00163470-03
NCGC00163470-04
NCGC00179232-01
NChemBio.2007.16-comp1
NINDS_001040
NSC717865
Prograf
Prograf (TN)
Protopic
Protopy
S5003_Selleck
SAM001246677
SMR000466356
Tacarolimus
Tacrolimus
Tacrolimus (INN)
Tacrolimus (Prograf?)
Tacrolimus (anhydrous)
Tacrolimus Hydrate
Tacrolimus anhydrous
Tacrolimus hydrate
Tsukubaenolide
UNII-Y5L2157C4J
nchembio.2007.23-comp2
tacrolimus
tacrolimus hydrate
8Calcium, Dietary3529
9Cyclosporins849

Interventional clinical trials:

idNameStatusNCT IDPhase
1Folic Acid Supplementation in Phenytoin Induced Gingival OvergrowthCompletedNCT00781196Phase 3
2Genes Associated With Hereditary and Drug-Induced Gingival OvergrowthCompletedNCT00104026
3Flapless Esthetic Crown Lengthening for the Treatment of Excessive Gingival DisplayCompletedNCT01821157
4Study of Immunosuppressive Therapy Toxicities in Kidney Transplant Recipients at Regional or Satellite Community ClinicsCompletedNCT00902980
5Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio DiseaseCompletedNCT02187185
6Diode Laser in Gingival Enlargement Related to OrthodonticsRecruitingNCT01286298

Search NIH Clinical Center for Gingival Overgrowth


Cochrane evidence based reviews: Gingival Overgrowth

Genetic Tests for Gingival Overgrowth

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Anatomical Context for Gingival Overgrowth

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MalaCards organs/tissues related to Gingival Overgrowth:

33
Heart, Bone, Kidney, Endothelial, Liver, Bone marrow, Lung

Animal Models for Gingival Overgrowth or affiliated genes

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MGI Mouse Phenotypes related to Gingival Overgrowth:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2CTGF, DCN, IL6, PDGFB, TGFB1, TIMP1
2MP:00053908.0CD36, CTGF, CTSL, DCN, IL6, MMP3
3MP:00107717.7CTGF, CTSB, CTSL, DCN, IL6, PDGFB
4MP:00053817.7CD36, CTGF, CTSB, CTSL, DCN, IL6
5MP:00053857.6CD36, CTGF, IL1A, IL6, PDGFB, TGFB1
6MP:00053917.6CD36, CTGF, CTSL, DCN, IL6, PDGFB
7MP:00053677.6CD36, CTSB, CTSL, DCN, IL6, PDGFB
8MP:00020067.5CTSB, DCN, IL1A, IL6, MMP1, TGFB1
9MP:00053797.3CD36, CTSB, CTSL, DCN, IL6, TGFB1
10MP:00107686.9CD36, CTGF, CTSB, CTSL, DCN, IL6
11MP:00053786.9CD36, CTGF, CTSB, CTSL, DCN, IL6
12MP:00053976.1CD36, CTSL, DCN, IL1A, IL6, MMP3
13MP:00053875.7CD36, CTSB, CTSL, DCN, IL1A, IL6
14MP:00053765.5CD36, CTGF, CTSB, CTSL, DCN, IL1A

Publications for Gingival Overgrowth

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Articles related to Gingival Overgrowth:

(show top 50)    (show all 414)
idTitleAuthorsYear
1
Are antimicrobial peptides related to cyclosporine A-induced gingival overgrowth? (25555253)
2015
2
Is periodontal health a predictor of drug-induced gingival overgrowth? A cross-sectional study. (25426150)
2014
3
Gingival overgrowth as secondary effect of calcium channel blockers administration. A case report. (25408733)
2014
4
Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth. (24581850)
2014
5
Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth. (23803025)
2013
6
Can chlorhexidine mouthwash twice daily ameliorate cyclosporine-induced gingival overgrowth? (23473525)
2013
7
Serum cyclophilin A concentrations in renal transplant recipients receiving cyclosporine A: clinical implications for gingival overgrowth. (24035111)
2013
8
Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts. (21883230)
2012
9
Loss of basement membrane integrity in human gingival overgrowth. (21483030)
2011
10
Gingival overgrowth and drug association: a review. (23196317)
2011
11
Surgical management of gingival overgrowth associated with Cowden sydrome: a case report and current understanding. (21519553)
2011
12
Gingival overgrowth secondary to amlodipine. (19749649)
2009
13
Gingival overgrowth in a renal transplant recipient using cyclosporine A. (19040821)
2008
14
Local inflammation exacerbates cyclosporine a-induced gingival overgrowth in rats. (18982435)
2008
15
Expression of fibronectin-binding integrins in gingival epithelium in drug-induced gingival overgrowth. (17305873)
2007
16
Apoptosis and expression of caspase-3 in cyclosporin-induced gingival overgrowth. (18052710)
2007
17
Clinical and pharmacological variables as a risk factor for nifedipine-induced gingival overgrowth. (18265685)
2007
18
The role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowth. (17989122)
2007
19
Apoptosis in gingival overgrowth tissues. (17720861)
2007
20
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (16670920)
2006
21
Elevated levels of gene expression for collagen and decorin in human gingival overgrowth. (16820039)
2006
22
Gingival overgrowth in renal transplant recipients induced by pharmacological treatment. Review of the literature. (16495873)
2006
23
Increased expression of vascular endothelial growth factor in cyclosporin A-induced gingival overgrowth in rats. (16579703)
2006
24
Apoptosis in cyclosporin A-induced gingival overgrowth: a histological study. (15974838)
2005
25
Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. (15732868)
2004
26
Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin A therapy. (15341348)
2004
27
CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects. (14659971)
2004
28
Connective tissue metabolism and gingival overgrowth. (15187034)
2004
29
Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. (12828653)
2003
30
The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients. (12662462)
2003
31
Cytomegalovirus and cyclosporin-induced gingival overgrowth in children with liver grafts. (12121533)
2002
32
Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1. (12378028)
2002
33
Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation. (12452980)
2002
34
Immunohistochemical analysis of epidermal growth factor receptor in cyclosporin A-induced gingival overgrowth. (11831486)
2001
35
Upregulation of keratinocyte growth factor in cyclosporin A-induced gingival overgrowth. (11453236)
2001
36
Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. (10052772)
1999
37
Nifedipine-associated gingival overgrowth: a survey of the literature and report of four cases. (9063228)
1996
38
Iatrogenic gingival overgrowth in cardiac transplantation. (7473018)
1995
39
Gingival overgrowth in paediatric cardiac transplant patients: a study of 19 patients aged between 2 and 16 years. (8957834)
1995
40
Dose-dependent gingival overgrowth induced by cyclosporin in rats. (7562351)
1995
41
Altered collagen metabolism in nifedipine-induced gingival overgrowth. (7877076)
1994
42
Periodontal management of nifedipine-induced gingival overgrowth: a case report and review of the pertinent literature. (8779668)
1994
43
Immunohistochemical study of 30 cases of cyclosporin A-induced gingival overgrowth. (7608852)
1994
44
Effect of periodontal treatment on gingival overgrowth among cyclosporine A-treated renal transplant recipients. (8295099)
1993
45
Gingival overgrowth among renal transplant recipients and uraemic patients. (8302465)
1993
46
The incidence and severity of nifedipine-induced gingival overgrowth. (1517474)
1992
47
Phenytoin-induced gingival overgrowth in rats infected with Streptococcus sobrinus 6715. (2151111)
1990
48
The reduction of phenytoin-induced gingival overgrowth in a severely disabled patient: a case report. (2605605)
1989
49
Cyclosporine-induced gingival overgrowth: an ultrastructural stereologic study. (3422723)
1988
50
Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. (3477745)
1987

Variations for Gingival Overgrowth

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Expression for genes affiliated with Gingival Overgrowth

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Search GEO for disease gene expression data for Gingival Overgrowth.

Pathways for genes affiliated with Gingival Overgrowth

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Pathways related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MMP1, TIMP1
2
Show member pathways
9.5MMP1, MMP3, TIMP1
39.5MMP1, MMP3, TIMP1
4
Angiogenesis (CST)
Show member pathways
9.5MMP1, MMP3, TIMP1
59.4IL6, TGFB1
69.1IL6, MMP1, TGFB1
78.9DCN, IL6, MMP1
88.9IL1A, IL6, TGFB1
98.9IL1A, IL6, TGFB1
108.9IL1A, IL6, TGFB1
118.8IL6, MMP1, PDGFB, TGFB1
128.8CD36, IL6, TGFB1
138.6CTSL, DCN, IL6, TGFB1
148.2CD36, IL1A, IL6, TIMP1
15
Show member pathways
8.1CTSB, CTSL, IL1A, IL6, TGFB1
16
Show member pathways
8.1CD36, IL6, PDGFB, TGFB1, TIMP1
17
Show member pathways
8.0CTGF, IL6, NUDT6, PDGFB, TGFB1, TIMP1
18
Show member pathways
8.0CTGF, IL6, NUDT6, PDGFB, TGFB1, TIMP1
19
Show member pathways
8.0CTGF, IL6, NUDT6, PDGFB, TGFB1, TIMP1
20
Show member pathways
8.0CTGF, IL6, NUDT6, PDGFB, TGFB1, TIMP1
21
Show member pathways
7.9CD36, IL6, MMP1, PDGFB, TGFB1, TIMP1
227.9CTSL, IL1A, IL6, MMP1, MMP3, TGFB1
23
Show member pathways
7.7CTSB, CTSL, DCN, MMP1, MMP3, PDGFB
24
Show member pathways
7.4CTGF, IL1A, IL6, NUDT6, PDGFB, TGFB1
25
Show member pathways
7.4CTGF, IL1A, IL6, NUDT6, PDGFB, TGFB1
26
Show member pathways
7.4CTGF, IL1A, IL6, NUDT6, PDGFB, TGFB1
27
Show member pathways
7.4CTGF, IL1A, IL6, NUDT6, PDGFB, TGFB1
28
Show member pathways
7.3CTGF, IL6, MMP1, MMP3, NUDT6, PDGFB

GO Terms for genes affiliated with Gingival Overgrowth

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Cellular components related to Gingival Overgrowth according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:003602110.2CTSB, CTSL
2platelet alpha granule lumenGO:003109310.2PDGFB, TGFB1, TIMP1
3extracellular matrixGO:00310129.0DCN, MMP1, MMP3, TIMP1
4proteinaceous extracellular matrixGO:00055788.7CTGF, DCN, MMP1, MMP3, TGFB1, TIMP1
5extracellular regionGO:00055765.8CTGF, CTSB, CTSL, DCN, IL1A, IL6
6extracellular spaceGO:00056155.8CD36, CTGF, CTSB, CTSL, DCN, IL1A

Biological processes related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of collagen biosynthetic processGO:003296710.6CTGF, TGFB1
2positive regulation of blood vessel endothelial cell migrationGO:004353610.5PDGFB, TGFB1
3cell activationGO:000177510.5TGFB1, TIMP1
4cellular response to thyroid hormone stimulusGO:009706710.5CTSB, CTSL
5connective tissue replacement involved in inflammatory response wound healingGO:000224810.4IL1A, TGFB1
6positive regulation of protein oligomerizationGO:003246110.4MMP1, MMP3
7positive regulation of chemotaxisGO:005092110.4PDGFB, TGFB1
8positive regulation of vascular endothelial growth factor productionGO:001057510.2IL1A, TGFB1
9response to fatty acidGO:007054210.1CD36, CTGF
10response to glucoseGO:000974910.1CTGF, CTSB, TGFB1
11response to estradiolGO:003235510.0CTGF, PDGFB, TGFB1
12response to peptide hormoneGO:004343410.0CTGF, CTSB, TIMP1
13response to organic substanceGO:00100339.9PDGFB, TGFB1, TIMP1
14cellular response to dexamethasone stimulusGO:00715499.8IL6, TGFB1
15negative regulation of gene expressionGO:00106299.8CD36, CTGF, TGFB1
16positive regulation of mitotic nuclear divisionGO:00458409.6IL1A, PDGFB
17toll-like receptor signaling pathwayGO:00022249.6CD36, CTSB, CTSL
18platelet degranulationGO:00025769.5CD36, PDGFB, TGFB1, TIMP1
19collagen catabolic processGO:00305749.4CTSB, CTSL, MMP1, MMP3
20response to cytokineGO:00340979.3CTSB, IL6, TIMP1
21cell growthGO:00160499.3IL6, PDGFB, TGFB1
22positive regulation of MAPK cascadeGO:00434109.3CD36, IL6, PDGFB
23response to mechanical stimulusGO:00096129.2CTSB, DCN, IL6
24agingGO:00075689.0DCN, IL6, TGFB1, TIMP1
25response to woundingGO:00096119.0CTGF, CTSB, IL6, PDGFB, TGFB1
26positive regulation of cell proliferationGO:00082848.9CTGF, IL6, PDGFB, TGFB1, TIMP1
27positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.9CD36, IL6, PDGFB, TGFB1
28response to organic cyclic compoundGO:00140708.9CTGF, CTSB, IL6, PDGFB, TGFB1
29blood coagulationGO:00075968.7CD36, MMP1, PDGFB, TGFB1, TIMP1
30extracellular matrix disassemblyGO:00226178.7CTSB, CTSL, DCN, MMP1, MMP3, TIMP1
31positive regulation of gene expressionGO:00106288.7CTGF, IL1A, IL6, PDGFB, TGFB1
32wound healingGO:00420608.7DCN, IL6, PDGFB, TGFB1, TIMP1
33positive regulation of ERK1 and ERK2 cascadeGO:00703748.3CD36, CTGF, IL1A, IL6, PDGFB
34platelet activationGO:00301688.0CD36, IL6, PDGFB, TGFB1, TIMP1
35extracellular matrix organizationGO:00301987.4CTSB, CTSL, DCN, MMP1, MMP3, PDGFB

Molecular functions related to Gingival Overgrowth according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:000196810.0CTGF, CTSL
2proteoglycan bindingGO:00433949.9CTSB, CTSL
3endopeptidase activityGO:00041759.4CTSB, MMP1, MMP3
4collagen bindingGO:00055189.0CTSB, CTSL, DCN, PDGFB
5cytokine activityGO:00051258.7IL1A, IL6, TGFB1, TIMP1
6growth factor activityGO:00080837.7CTGF, IL6, NUDT6, PDGFB, TGFB1, TIMP1

Sources for Gingival Overgrowth

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet