Gingival Overgrowth malady

Wikipedia: Gingival enlargement, the currently accepted terminology for an increase in the size of the gingiva, is...⁴⁴ more...

MalaCards: Gingival Overgrowth, also known as gingival enlargement nos (disorder), is related to periodontitis and gingivitis. An important gene associated with Gingival Overgrowth is DCN (decorin), and among its related pathways are Glioma Invasiveness and Inhibition of Matrix Metalloproteinases. The compounds egcg and hydroxyproline have been mentioned in the context of this disorder. Affiliated tissues include kidney and b cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

gingival overgrowth 6 8 32 43 gingival enlargement nos (disorder) 6 gingival enlargement (disorder) 6

gingival enlargement nos 6 gingival hyperplasia 43

Diseases related to gingival overgrowth by text searches and GeneDecks gene sharing:

(show top 50)    (show all 769)

id	Related Disease	Score	Top Affiliating Genes
1	periodontitis	28.5	BSG, CD36, MMP1, MMP3, MMP8, IL1A
2	gingivitis	22.2	PIGO, PCNA, BSG, MS4A1, CD36, ITGA2
3	localized scleroderma	13.8	CD36, MMP1, LOX, DCN
4	osteogenesis imperfecta type 4	13.8	CD36, COL1A1, DSPP
5	epidermolysis bullosa dystrophica	13.8	CD36, MMP1, MMP3
6	nephrogenic systemic fibrosis	13.8	CTGF, TIMP1, TGFB1, DCN
7	aggressive periodontitis	13.8	MMP1, MMP8, IL1A
8	sorsby fundus dystrophy	13.8	MMP3, TIMP1, TIMP3
9	osteoarthritis susceptibility 6	13.8	MMP1, MMP3, TIMP1
10	bullous keratopathy	13.7	IL1A, PDGFB, TIMP1, TGFB1, DCN
11	alport syndrome	13.7	ITGA2, MMP3, COL1A1, TGFB1
12	conduction disease	13.7	CD36, MMP1, TIMP1, TGFB1
13	ossification of posterior longitudinal ligament of spine	13.7	CD36, IL1A, IL1B, TGFB1
14	odontogenic myxoma	13.7	CD36, MMP1, DCN
15	keratopathy	13.7	IL1A, PDGFB, TIMP1, TGFB1, DCN
16	collagenous colitis	13.7	MMP1, CTGF, TIMP1
17	spinal stenosis	13.7	MMP3, SPARC, TIMP1, TGFB1
18	caffey disease	13.7	CD36, COL1A1
19	dermatofibrosarcoma protuberans	13.6	MMP1, MMP3, COL1A1, PDGFB, TGFBR2
20	pseudoachondroplasia	13.6	CD36, THBS1, DCN
21	osteogenesis imperfecta	13.6	CD36, LOX, SPARC, COL1A1, DSPP, DCN
22	dermatofibrosarcoma	13.6	MMP1, MMP3, COL1A1, PDGFB, TGFBR2
23	superior limbic keratoconjunctivitis	13.6	MMP1, MMP3
24	ehlers-danlos syndrome	13.6	CD36, LOX, COL1A1, THBS2, DSPP, DCN
25	chorioangioma	13.6	ANGPT2, ANGPT1, SPARC
26	fibromatosis, gingival	13.6	CD36, MMP1, TGFB1, SOS1
27	basal cell carcinoma	13.6	ITGA2, MMP1, MMP3, TGFBR2, DCN
28	corneal disease	13.5	GSN, IL1A, NGF
29	cutis laxa	13.5	GSN, LOX, ELANE, TGFB1
30	abdominal aortic aneurysm	13.5	MMP1, MMP3, MMP8, CTSL1, ELANE, TIMP1
31	marfan syndrome	13.5	CD36, LOX, ELANE, TGFB1, TGFBR2, DCN
32	corneal edema	13.5	MMP1, MMP3, IL1B
33	keratoconjunctivitis sicca	13.5	IL1A, HSPG2, NGF
34	refractive error	13.5	MMP1, MMP10, MMP3, MMP8, TIMP1, TIMP3
35	oral lichen planus	13.4	MMP1, IL1A, CASP3
36	malignant histiocytosis	13.4	IL1A, IL1B, TFRC
37	diabetic foot ulcers	13.4	FGF2, PDGFB, TGFB1, TGFBR2
38	corneal neovascularization	13.4	CD36, FGF2, TIMP4, THBS1
39	aneurysm disease	13.4	MMP1, IL1B, ACE, TIMP1
40	ureteral obstruction	13.4	CD36, PTPRC, TIMP1, TGFB1, HGF
41	angiofibroma	13.4	PCNA, SPARC, PDGFB, DCN, NUDT6
42	lipodermatosclerosis	13.3	PCNA, ANGPT2, ANGPT1, COL1A1
43	coronary heart disease	13.3	CD36, MMP3, TNF
44	recessive dystrophic epidermolysis bullosa	13.3	MMP1, MMP3, FGF2
45	keloids	13.3	CD36, MMP1, MMP8, FGF2, LOX, CTGF
46	benign tumors	13.3	PCNA, BSG, CTSB, CTSL1, PDGFB, NUDT6
47	nephrosclerosis	13.3	CTGF, ACE, THBS1, TGFB1
48	chronic ulcer of skin	13.3	CD36, MMP1, MMP8, FGF2, PDGFB, ELANE
49	cicatricial pemphigoid	13.3	IL1A, IL1B, TNF, CTGF, TGFB1
50	posterior uveal melanoma	13.2	PCNA, THBS1, THBS2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to gingival overgrowth:

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MGI Mouse Phenotypes related to gingival overgrowth:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	GSN, PTPRC, PDGFB, THBS2
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	CTLA4, IL2, GSN
3	craniofacial phenotype	MP:0005382	9.5	SOS1, DSPP, EDNRB, EDN1, HSPG2
4	embryogenesis phenotype	MP:0005380	9.3	SOS1, EGFR, EDNRB, COL1A1
5	renal/urinary system phenotype	MP:0005367	9.2	DCN, THBS1, EGFR, EDNRB, PDGFB, CTSL1
6	pigmentation phenotype	MP:0001186	9.1	EGFR, EDNRB, PDGFB, COL1A1, CTLA4, CASP3
7	no phenotypic analysis	MP:0003012	8.9	SOS1, EGFR, EDNRB, PDGFB, COL1A1, ANTXR2
8	hematopoietic system phenotype	MP:0005397	8.9	PCNA, ITGA2, GSN, FGF2, FGF7, PTPRC
9	integument phenotype	MP:0010771	8.8	GSN, ITGA2, FGF7, ANGPT2, SOS1, THBS2
10	reproductive system phenotype	MP:0005389	8.5	TGFB1, THBS1, TIMP3, TIMP1, PDGFB, CTSL1
11	hearing/vestibular/ear phenotype	MP:0005377	8.1	ABCB1, EGFR, EDNRB, EDN1, COL1A1, CTSL1
12	nervous system phenotype	MP:0003631	8.0	COL1A1, NGF, EDN1, EDNRB, EGFR, TGFB1
13	liver/biliary system phenotype	MP:0005370	8.0	CTLA4, CTSL1, EGFR, ABCB1, PTPRC, HSPG2
14	skeleton phenotype	MP:0005390	7.9	CTLA4, CTSL1, EDNRB, EGFR, THBS1, TGFBR2
15	digestive/alimentary phenotype	MP:0005381	7.5	EDNRB, EGFR, THBS1, TGFB1, TGFBR2, TFRC
16	behavior/neurological phenotype	MP:0005386	7.1	EDNRB, ABCB1, ACE, TIMP3, THBS2, TGFBR2
17	muscle phenotype	MP:0005369	7.0	EGFR, TIMP3, THBS1, THBS2, TGFB1, TGFBR2
18	vision/eye phenotype	MP:0005391	6.9	PDGFB, EDNRB, EGFR, TIMP3, THBS1, TGFB1
19	immune system phenotype	MP:0005387	6.3	BSG, TFRC, DCN, THBS1, ELANE, EGFR
20	tumorigenesis	MP:0002006	5.9	IL1B, IL2, IL6, TNF, PTPRC, SPARC
21	growth/size phenotype	MP:0005378	5.7	EDNRB, EGFR, ACE, TIMP3, THBS1, TGFBR2
22	homeostasis/metabolism phenotype	MP:0005376	5.5	THBS2, TGFB1, TGFBR2, TFRC, DCN, SOS1
23	mortality/aging	MP:0010768	5.5	BSG, CD36, GSN, IL1B, IL6, ANGPT2
24	cellular phenotype	MP:0005384	3.7	HGF, SOS1, DCN, TFRC, TGFBR2, TGFB1
25	cardiovascular system phenotype	MP:0005385	3.6	CTLA4, COL1A1, PDGFB, EDN1, EDNRB, EGFR

Articles related to gingival overgrowth:

(show all 49)

id	Title	Authors	Year	Affiliating Genes
1	TGF-I^1 gene polymorphism in renal transplant patients with and without gingival overgrowth. (21306480)	Kozak M.... Drozdzik M.	2011	TGFB1
2	Differences in the expression of glycosaminoglycans i n human fibroblasts derived from gingival overgrowths is related to TGF-beta up -regulation. (19886734)	Dreyfuss J.L.... Nader H.B.	2010	TGFBR2, TGFB1, HYAL1
3	Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth. (19778329)	Drozdzik A.... Drozdzik M.	2010	MMP3
4	Gingival overgrowth in cyclosporine, tacrolimus, or s irolimus-based immunosuppressive regimens and the single nucleotide IL-6 (-174 G/C) gene polymorphism. (20430366)	Cota L.O.... Costa F.O.	2010	IL6
5	Correlations between the gingival crevicular fluid MM P8 levels and gingival overgrowth in patients with fixed orthodontic devices. (20809029)	Surlin P.... Pirici D.	2010	MMP8
6	Differential gene and protein expression of tissue in hibitors of metalloproteinases (TIMP)-3 and TIMP-4 in gingival tissues from dru g induced gingival overgrowth. (19450793)	Nakasone N.... Yoshie H.	2009	TIMP3, TIMP4
7	Gingival crevicular fluid transforming growth factor-beta1 in cyclosporine and tacrolimus treated renal transplant patients without gingival overgrowth. (18342291)	GA1rkan A.... Atilla G.	2008	TGFB1
8	Do MMP-1 levels of gingival fibroblasts have a role in the gingival overgrowth of cyclosporine-treated patients? (18261580)	Sonmez S.... Camsari T.	2008	MMP1
9	Non-surgical periodontal treatment of cyclosporin A-induced gingival overgrowth: immunohistochemical results. (18266838)	Aimetti M.... Navone R.	2008	MS4A1
10	Role of MDR1 gene polymorphisms in gingival overgrowth induced by cyclosporine in transplant patients. (18702631)	De Iudicibus S.... Bartoli F.	2008	ABCB1
11	Transforming growth factor-beta1 gene expression and cyclosporine A-induced gingival overgrowth: a pilot study. (18355347)	Radwan-Oczko M.... Dobosz T.	2008	TGFB1
12	Connective tissue growth factors, CTGF and Cyr61 in drug-induced gingival overgrowth--an animal model (20209781)	CiobanicA8 M.... Cianga P.	2008	CTGF
13	Apoptosis and expression of caspase-3 in cyclosporin- induced gingival overgrowth. (18052710)	Bulut S.... Ozdemir B.H.	2007	CASP3
14	Stimulation of cells derived from nifedipine-induced gingival overgrowth with Porphyromonas gingivalis, lipopolysaccharide, and interleukin-1beta. (17959904)	Lu H.K.... Wang L.F.	2007	IL1B, CTGF
15	Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients. (18021981)	Kusztal M.... Klinger M.	2007	TNF, IL2, CTLA4
16	Apoptosis in gingival overgrowth tissues. (17720861)	Kantarci A.... Trackman P.C.	2007	CASP3
17	Endothelin-1 and its receptors ET(A) and ET(B) in drug-induced gingival overgrowth. (17274718)	Tamilselvan S.... Suresh R.	2007	EDNRB, EDN1
18	SPARC gene polymorphism in renal transplant patients with gingival overgrowth. (17970686)	Drozdzik A.... Drozdzik M.	2007	SPARC
19	Elevated levels of gene expression for collagen and decorin in human gingival overgrowth. (16820039)	Dannewitz B.... Steinberg T.	2006	DCN
20	The relationship of transforming growth factor-beta1 gene polymorphism, its plasma level, and gingival overgrowth in renal transplant recipients receiving different immunosuppressive regimens. (16671880)	Radwan-Oczko M.... Jonkisz A.	2006	TGFB1
21	Relationship between IL-1A polymorphisms and gingival overgrowth in renal transplant recipients receiving Cyclosporin A. (16965524)	Bostanci N.... McKay I.J.	2006	IL6, IL1B, IL8
22	Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (16670920)	Dannewitz B.... Steinberg T.	2006	MMP1, MMP10
23	Analysis of proliferative activity in oral gingival e pithelium in immunosuppressive medication induced gingival overgrowth. (16712728)	Bulut S.... Bulut O.E.	2006	PCNA
24	Expression of transforming growth factor-beta receptor II mRNA in cyclosporine-induced gingival overgrowth. (17112860)	Stefanidou V.... Stefanidis I.	2006	TGFBR2
25	Drug-induced gingival overgrowth--a review. (16204928)	Kataoka M.... Nagata T.	2005	GSN
26	Interleukin-6 gene polymorphism in renal transplant patients with and without gingival overgrowth. (16104959)	Drozdzik M.... Pawlik A.	2005	IL6
27	Alpha 2 integrin +807 polymorphism in drug-induced gingival overgrowth. (16304451)	Ogino M.... Kataoka M.	2005	CD36, ITGA2
28	CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects. (14659971)	Soga Y.... Oka E.	2004	CYP2C19, CYP2C9
29	Plasma TGF-beta1 as a risk factor for gingival overgrowth. (15367190)	Ellis J.S.... Thomason J.M.	2004	TGFB1
30	Crevicular fluid levels of TGFbeta1 in drug-induced gingival overgrowth. (15041490)	Wright H.J.... Matthews J.B.	2004	TGFB1
31	Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. (15732868)	Bulut O.E.... Muftuoglu S.	2004	PTPRC, TFRC, ITGAL
32	P-glycoprotein drug transporter MDR1 gene polymorphism in renal transplant patients with and without gingival overgrowth. (15312098)	Drozdzik M.... Grabarek J.	2004	ABCB1
33	Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. (15250830)	Hyland P.L.... Irwin C.R.	2004	HGF, FGF7
34	Salivary proteins and cytokines in drug-induced gingival overgrowth. (15044507)	Ruhl S.... Thomason J.M.	2004	NGF
35	Decreased expressions of thrombospondin 2 in cyclosporin A-induced gingival overgrowth. (15009516)	Koh J.T.... Kim K.K.	2004	FGF2, ANGPT1, THBS1
36	Effect of cyclosporin A on human gingival fibroblast collagen turnover in relation to the development of gingival overgrowth: an in vitro study. (15183848)	Gagliano N.... Gioia M.	2004	MMP1
37	Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth. (14974815)	Gnoatto N.... Marquezini M.V.	2003	HSPG2, DCN
38	Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice. (12466121)	Nishimura F.... Murayama Y.	2002	CTSB, CTSL1
39	Amlodipine-induced gingival overgrowth: periodontal r esponses to stopping and restarting the drug. (11484582)	Morisaki I.... Mihara J.	2001	ACE
40	Immunohistochemical analysis of epidermal growth factor receptor in cyclosporin A-induced gingival overgrowth. (11831486)	Buduneli N.... Holmstrup P.	2001	EGFR
41	Upregulation of keratinocyte growth factor in cyclosporin A-induced gingival overgrowth. (11453236)	Das S.J.... Olsen I.	2001	FGF7
42	TGF-beta isoforms and TGF-beta receptors in drug-induced and hereditary gingival overgrowth. (11334464)	Wright H.J.... Matthews J.B.	2001	TGFB1
43	The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker. (11453244)	Linden G.J.... James J.A.	2001	TGFB1
44	Connective tissue growth factor in drug-induced gingival overgrowth. (11495141)	Uzel M.I.... Trackman P.C.	2001	CTGF
45	Cyclosporin A regulates interleukin-1beta and interle ukin-6 expression in gingiva: implications for gingival overgrowth. (10225546)	Myrillas T.T.... Irwin C.R.	1999	IL6
46	Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. (9477019)	Sasaki T.... Maita E.	1998	NUDT6
47	Possible roles of medullasin in nifedipine-induced human gingival overgrowth. (8833599)	Kunimatsu K.... Kato I.	1996	ELANE
48	PDGF-B producing cells and PDGF-B gene expression in normal gingival and cyclosporine A-induced gingival overgrowth. (8708959)	Plemons J.M.... Iacopino A.M.	1996	PDGFB
49	Cyclosporine A upregulates interleukin-6 gene express ion in human gingiva: possible mechanism for gingival overgrowth. (7823269)	Williamson M.S.... Iacopino A.M.	1994	IL6

Genes related to gingival overgrowth according to GeneCards:

(show top 50)    (show all 61)

id	Symbol	Description	Score	GeneCards Section Context
1	DCN	decorin	11.0	Publications
2	FGF7	fibroblast growth factor 7	11.0	Publications
3	CTSL1	cathepsin L1	11.0	Publications
4	CTGF	connective tissue growth factor	11.0	Publications
5	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	11.0	Publications
6	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
7	LOX	lysyl oxidase	11.0
8	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
9	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0
10	CTSB	cathepsin B	11.0	Publications
11	COL1A1	collagen, type I, alpha 1	11.0
12	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	11.0	Publications
13	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
14	TGFB1	transforming growth factor, beta 1	11.0	Publications
15	DSPP	dentin sialophosphoprotein	11.0
16	TIMP1	TIMP metallopeptidase inhibitor 1	11.0
17	IL1A	interleukin 1, alpha	11.0	Publications
18	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
19	IL1B	interleukin 1, beta	11.0	Publications
20	TIMP4	TIMP metallopeptidase inhibitor 4	11.0	Publications
21	HAS3	hyaluronan synthase 3	11.0	Publications
22	PIGO	phosphatidylinositol glycan anchor biosynthesis, class O	11.0
23	GIN1	gypsy retrotransposon integrase 1	11.0
24	HYAL1	hyaluronoglucosaminidase 1	11.0	Publications
25	MMP10	matrix metallopeptidase 10 (stromelysin 2)	11.0	Publications
26	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0	Publications
27	THBS2	thrombospondin 2	11.0	Publications
28	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
29	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	11.0	Publications
30	ANGPT2	angiopoietin 2	11.0	Publications
31	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
32	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
33	ANTXR2	anthrax toxin receptor 2	11.0
34	EDNRB	endothelin receptor type B	11.0	Publications
35	GSN	gelsolin	11.0	Publications
36	BSG	basigin (Ok blood group)	11.0	Publications
37	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
38	THBS1	thrombospondin 1	11.0	Publications
39	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
40	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
41	TFRC	transferrin receptor (p90, CD71)	11.0	Publications
42	ANGPT1	angiopoietin 1	11.0	Publications
43	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
44	SOS1	son of sevenless homolog 1 (Drosophila)	11.0
45	CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	11.0	Publications
46	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
47	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
48	CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	11.0	Publications
49	ELANE	elastase, neutrophil expressed	11.0	Publications
50	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications

Pathways related to gingival overgrowth according to GeneDecks:

(show top 50)    (show all 138)

id	Pathway	Score	Top Affiliating Genes
1	Glioma Invasiveness36	9.8	ITGAL, FGF2, FGF7, PDGFB, TIMP1, TIMP3
2	Inhibition of Matrix Metalloproteinases36	9.8	TIMP3, TIMP1, TIMP4, THBS2, MMP8, MMP3
3	Actin-Based Motility by Rho Family GTPases36	9.5	TIMP4, CTGF, FGF7, IL2, ITGAL, GSN
4	Ras Pathway36	9.3	ITGA2, FGF2, FGF7, CTGF, PDGFB, EGFR
5	ILK Signaling36	9.2	TIMP1, EGFR, PDGFB, COL1A1, CTGF, HSPG2
6	14-3-3 Induced Intracellular Signaling36	9.2	TNF, FGF2, CTGF, PDGFB, NUDT6, TIMP1
7	Paxillin Interactions36	9.2	ITGA2, ITGAL, FGF2, FGF7, CTGF, PDGFB
8	CREB Pathway36	9.2	IL2, SOS1, NUDT6, TIMP3, FGF7, TIMP4
9	JNK Pathway36	8.7	IL2, FGF7, FGF2, TIMP4, NUDT6, TGFB1
10	Malaria20	8.5	THBS2, ITGAL, IL1B, IL6, IL8, TNF
11	Rheumatoid arthritis20	8.5	ITGAL, MMP1, MMP3, IL1A, IL1B, IL6
12	Telomerase Components in Cell Signaling36	8.4	NUDT6, HGF, TIMP4, FGF2, FGF7, IL2
13	ERK5 Signaling36	8.4	TIMP4, NUDT6, HGF, TGFB1, IL6, TIMP3
14	eNOS Signaling36	8.4	IL2, CASP3, PDGFB, EGFR, TIMP1, TIMP4
15	IP3 Pathway36	8.2	IL2, FGF7, FGF2, HGF, SOS1, NUDT6
16	Akt Signaling36	8.1	IL2, FGF7, ITGAL, ITGA2, IL6, ANGPT1
17	Epithelial Adherens Junctions36	8.0	TGFBR2, NUDT6, TIMP4, HGF, CTGF, TIMP3
18	eIF2 Pathway36	7.9	HGF, SOS1, TIMP3, NUDT6, TIMP4, TIMP1
19	p53 Mediated Apoptosis36	7.9	FGF7, IL2, IL6, CASP3, CTGF, PDGFB
20	PTEN Pathway36	7.9	HSPG2, CTGF, COL1A1, PDGFB, EGFR, TIMP3
21	Mitochondrial Apoptosis36	7.9	FGF7, IL2, IL6, CASP3, CTGF, PDGFB
22	Nanog in Mammalian ESC Pluripotency36	7.9	FGF2, CTGF, IL2, IL6, FGF7, PDGFB
23	Rac1 Pathway36	7.9	ITGA2, ITGAL, FGF2, HGF, NUDT6, TGFB1
24	ERK Signaling36	7.9	SOS1, TGFB1, TIMP4, ITGAL, FGF7, IL1A
25	DHA Signaling36	7.8	TIMP3, TIMP4, TGFB1, NUDT6, HGF, CASP3
26	p70S6K Signaling36	7.8	TIMP3, TIMP4, TIMP1, EGFR, PDGFB, CTGF
27	Nuclear Receptor Activation by Vitamin-A36	7.8	TGFB1, NUDT6, IL6, PDGFB, TIMP4, TIMP3
28	Activation of PKC through GPCR36	7.8	PDGFB, CTGF, IL6, IL2, FGF7, EGFR
29	Rap1 Pathway36	7.8	TIMP4, TGFB1, NUDT6, SOS1, HGF, TIMP3
30	PPAR Pathway36	7.7	ITGA2, ITGAL, FGF2, FGF7, IL2, IL6
31	Endothelin-1 Signaling Pathway36	7.7	IL2, EDN1, CASP3, IL1B, IL6, IL1A
32	Apoptotic Pathways in Synovial Fibroblasts36	7.6	TIMP3, TIMP4, TGFB1, NUDT6, HGF, TIMP1
33	NF-KappaB (p50-p65) Pathway36	7.5	IL2, IL6, TNF, CTGF, PDGFB, EGFR
34	NF-KappaB Family Pathway36	7.5	CTGF, PDGFB, EGFR, TIMP1, TIMP3, TIMP4
35	Pancreatic Adenocarcinoma36	7.5	TIMP4, TGFB1, TGFBR2, NUDT6, SOS1, HGF
36	Phospholipase-C Pathway36	7.5	ITGA2, ITGAL, FGF2, FGF7, IL2, IL6
37	NFAT in Immune Response36	7.5	NUDT6, TGFB1, TIMP4, TIMP3, SOS1, EGFR
38	Rho Family GTPases36	7.4	IL1B, IL2, IL8, ANGPT2, ANGPT1, HSPG2
39	Renin-Angiotensin Pathway36	7.3	HGF, SOS1, NUDT6, TGFB1, FGF2, FGF7
40	Cellular Apoptosis Pathway36	7.3	FGF2, FGF7, IL2, IL6, CASP3, TNF
41	Estrogen Pathway36	7.3	PDGFB, EGFR, IL6, IL2, CTGF, FGF2
42	JAK-STAT Pathway36	7.0	IL8, ANGPT2, ANGPT1, CTGF, PDGFB, EGFR
43	Molecular Mechanisms of Cancer36	6.9	TGFB1, TGFBR2, NUDT6, SOS1, HGF, ITGA2
44	TGF-Beta Pathway36	6.8	TIMP4, TGFB1, TGFBR2, NUDT6, SOS1, HGF
45	MAPK Signaling36	6.7	TIMP1, TIMP4, EGFR, COL1A1, IL6, HGF
46	Antioxidant Action of Vitamin-C36	6.6	ANGPT1, TNF, CTGF, PDGFB, EGFR, TIMP1
47	Tec Kinases Signaling36	6.4	TIMP3, TIMP4, TGFB1, NUDT6, HGF, TIMP1
48	PAK Pathway36	6.3	FGF2, FGF7, IL1A, IL1B, IL2, IL6
49	MAPK Family Pathway36	6.3	FGF2, FGF7, IL1A, IL1B, HGF, SOS1
50	p38 Signaling36	6.1	TIMP1, TIMP3, TIMP4, TGFB1, NUDT6, SOS1

Compounds related to gingival overgrowth according to GeneDecks:

(show top 50)    (show all 369)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.2	TIMP1, ELANE, SRD5A1, HSPG2, IL1A
2	hydroxyproline32 18	10.8	DCN, TGFB1, TIMP1, COL1A1, CTSL1, CTSB
3	glycosaminoglycan32	9.7	HAS3, DCN, THBS1, TIMP3, COL1A1, LOX
4	hyaluronic acid32 18	10.6	MMP1, ITGAL, CD36, MMP3, FGF2, HAS3
5	procollagen32	9.3	DCN, PCNA, TGFB1, THBS2, THBS1, TIMP1
6	h2o232	9.3	LOX, MMP8, ITGAL, TFRC, DSPP, ELANE
7	glucose32	9.3	SLC7A5, NUDT6, PDGFB, CTSL1, CTGF, SPARC
8	doxycycline32 9 9	11.3	NUDT6, TFRC, DSPP, THBS1, TIMP1, ELANE
9	ribonucleic acid32	9.3	MMP3, MMP1, FGF7, IL1A, NUDT6, DCN
10	heparin32 9 18 9	11.9	HGF, DCN, THBS2, TIMP3, TIMP1, ELANE
11	tetracycline32 9 9	10.8	MMP1, TFRC, TGFBR2, TGFB1, DSPP, THBS1
12	oxygen32 18	9.4	CTGF, CYP2C9, CYP2C19, CASP3, LOX, ANGPT1
13	glutamate32	8.4	ITGAL, ITGA2, BSG, PCNA, MMP3, GSN
14	calcitriol32 42 9 18 9	12.4	TFRC, DSPP, THBS1, TIMP1, NGF, SPARC
15	tgf beta132	8.4	DCN, TGFBR2, THBS2, THBS1, TIMP3, TIMP1
16	pge232	8.2	EGFR, EDNRB, EDN1, CTSB, SPARC, HSPG2
17	progesterone32 42 9 18 9	12.2	SPARC, SRD5A1, CYP2C9, CYP2C19, PTPRC, MMP8
18	histamine32 18	9.2	PCNA, FGF7, HGF, TFRC, TIMP1, EDN1
19	sb 20358032 42	8.9	BSG, CD36, MMP1, HGF, THBS1, TIMP1
20	simvastatin32 34 42 9 18 9	12.8	MMP3, ITGAL, ABCB1, COL1A1, CTGF, CYP2C9
21	curcumin32	7.8	TGFB1, TIMP1, ABCB1, EGFR, CTGF, TNF
22	matrigel32	7.8	HGF, NUDT6, DCN, THBS1, ITGA2, CD36
23	losartan32 34 9 9	10.8	TGFB1, ACE, ABCB1, EDNRB, EDN1, CTGF
24	thalidomide32 42 9 9	10.6	HGF, THBS1, CTLA4, CYP2C9, CYP2C19, TNF
25	cysteine32	7.6	ELANE, EDNRB, COL1A1, CTSL1, CTSB, CTGF
26	testosterone32 9 18 9	10.5	HGF, NUDT6, TFRC, THBS1, TIMP3, ELANE
27	estrogen32	7.4	CTSL1, CTSB, CTGF, SPARC, SRD5A1, CYP2C19
28	ly29400232	7.4	TGFB1, THBS1, TIMP3, TIMP1, CTSB, CTLA4
29	tacrolimus32 34 9 9	10.4	HGF, TFRC, TGFB1, TIMP1, ABCB1, PDGFB
30	paraffin32	7.3	HGF, DCN, TFRC, TGFB1, DSPP, THBS1
31	paclitaxel32 34 9 9	10.2	HGF, TFRC, TGFB1, THBS1, TIMP1, ABCB1
32	hydrocortisone32 9 9	9.1	CD36, HGF, HAS3, ELANE, ABCB1, TNF
33	prostacyclin32	6.9	IL1B, IL1A, FGF2, ANGPT1, LOX, HGF
34	alanine32	6.9	FGF2, GSN, MMP8, MMP3, ITGAL, PCNA
35	calcium32 9 18 9	9.8	SPARC, CYP2C9, PTPRC, HSPG2, ANGPT1, ANTXR2
36	vegf32	6.5	HGF, SLC7A5, NUDT6, DCN, TGFBR2, TGFB1
37	phosphatidylinositol32	6.5	HGF, SOS1, NUDT6, TFRC, THBS1, GSN
38	pd 98,05932	6.3	HGF, NUDT6, DCN, TGFB1, THBS1, TIMP3
39	nitric oxide32 9 18 9	9.1	ANGPT2, IL8, IL6, IL1B, IL1A, FGF7
40	herbimycin a32 42	7.1	TIMP1, EGFR, EDN1, NGF, PTPRC, TNF
41	indomethacin32 9 9	8.0	NGF, CTSB, SRD5A1, CYP2C9, CYP2C19, TNF
42	retinoic acid32 42 18	8.0	MMP3, MMP1, ITGAL, ITGA2, CD36, SRD5A1
43	actinomycin d32	6.0	IL6, IL2, IL1B, IL1A, FGF7, FGF2
44	thymidine32 18	6.7	HGF, NUDT6, TFRC, TGFB1, THBS2, THBS1
45	cyclosporin a32 42	5.9	FGF7, FGF2, MMP3, MMP1, ITGAL, BSG
46	cycloheximide32	4.7	HSPG2, LOX, IL8, IL6, IL2, IL1B
47	tyrosine32	4.6	TIMP1, ANGPT2, IL6, IL2, FGF7, FGF2
48	genistein32 9 18 9	7.3	IL2, IL1B, IL1A, FGF7, FGF2, MMP8
49	dexamethasone32 42 34 9 9	7.8	SRD5A1, MMP1, ITGAL, CD36, PCNA, MMP3
50	serine32	3.6	TGFBR2, TGFB1, DSPP, THBS2, THBS1, TIMP1

Cellular components related to gingival overgrowth according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hyaluranon cable	GO:036117	10.3	HYAL1, HAS3
2	proteinaceous extracellular matrix	GO:005578	9.9	TGFB1, DSPP, CTGF, SPARC, MMP8, MMP3
3	platelet alpha granule lumen	GO:031093	9.9	HGF, TGFB1, THBS1, TIMP1, PDGFB, SPARC
4	basement membrane	GO:005604	9.9	THBS2, TIMP3, TIMP1, SPARC, HSPG2
5	cell surface	GO:009986	9.0	TGFB1, ELANE, ABCB1, PDGFB, TNF, IL1A
6	membrane raft	GO:045121	8.8	EGFR, PTPRC, TNF, ANGPT1, CD36, BSG
7	external side of plasma membrane	GO:009897	8.4	TGFBR2, THBS1, ACE, CTSB, CTLA4, PTPRC
8	plasma membrane	GO:005886	5.3	CTLA4, EDNRB, EGFR, ABCB1, ACE, TGFBR2
9	extracellular region	GO:005576	5.1	HGF, DCN, ANTXR2, ANGPT2, IL8, IL6
10	extracellular space	GO:005615	4.3	HGF, ANGPT1, ANGPT2, IL8, IL6, IL2

Biological processes related to gingival overgrowth according to GeneDecks:

(show top 50)    (show all 56)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to L-ascorbic acid	GO:033591	10.5	SPARC, IL1B, IL1A
2	hyaluronan biosynthetic process	GO:030213	10.5	HAS3, HYAL1, IL1B
3	collagen catabolic process	GO:030574	10.4	MMP1, MMP10, MMP3, MMP8
4	positive regulation of chemotaxis	GO:050921	10.4	TGFB1, THBS1, PDGFB
5	response to organic cyclic compound	GO:014070	10.3	TIMP3, PDGFB, CTSB, CTGF, ANGPT2, IL1A
6	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.3	CD36, PDGFB, THBS1, TGFBR2
7	response to wounding	GO:009611	10.3	TGFB1, PDGFB, CTSB, CTGF, CASP3, FGF7
8	response to glucose stimulus	GO:009749	10.3	TGFB1, THBS1, CTSB, CTGF, ANGPT2
9	aging	GO:007568	10.3	DCN, TGFB1, TIMP3, TIMP1, IL1B, GSN
10	wound healing	GO:042060	10.2	DCN, LOX, IL1B, IL1A, FGF7, FGF2
11	extracellular matrix disassembly	GO:022617	10.2	TIMP1, ELANE, MMP8, MMP3, MMP10, MMP1
12	positive regulation of cell division	GO:051781	10.2	TGFB1, PDGFB, IL1B, IL1A, FGF7, FGF2
13	negative regulation of blood vessel endothelial cell migration	GO:043537	10.2	FGF2, ANGPT2, THBS1, TGFB1
14	positive regulation of blood vessel endothelial cell migration	GO:043536	10.1	TGFB1, THBS1, PDGFB, ANGPT1, FGF2
15	response to peptide hormone stimulus	GO:043434	10.1	TIMP4, TIMP1, NGF, COL1A1, CTSB, CTGF
16	platelet degranulation	GO:002576	10.1	HGF, TGFB1, THBS1, TIMP1, PDGFB, SPARC
17	cellular response to growth factor stimulus	GO:071363	10.0	SRD5A1, SPARC, COL1A1, TGFB1
18	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.0	HGF, PDGFB, ANGPT1, IL6, FGF7, CD36
19	positive regulation of angiogenesis	GO:045766	10.0	THBS1, HYAL1, ANGPT2, IL1B, IL1A, FGF2
20	cellular response to organic cyclic compound	GO:071407	9.9	TGFB1, SRD5A1, TNF, IL1B
21	ossification	GO:001503	9.9	MMP8, SPARC, CTGF, EGFR, DSPP
22	positive regulation of T cell proliferation	GO:042102	9.8	ITGAL, IL1B, IL6, PTPRC
23	response to mechanical stimulus	GO:009612	9.8	DCN, TIMP3, NGF, CTSB, TNF, ANGPT2
24	positive regulation of interleukin-6 production	GO:032755	9.8	TNF, IL6, IL1B, IL1A, CD36
25	positive regulation of JNK cascade	GO:046330	9.7	IL1A, IL1B, TNF, CTGF
26	positive regulation of mitosis	GO:045840	9.7	EDN1, PDGFB, TNF, IL1B, IL1A
27	response to lipopolysaccharide	GO:032496	9.7	DCN, TIMP4, ELANE, EDN1, NGF, SPARC
28	extracellular matrix organization	GO:030198	9.6	TIMP1, ELANE, COL1A1, TNF, MMP8, MMP3
29	leukocyte migration	GO:050900	9.6	SLC7A5, SOS1, ELANE, COL1A1, ANGPT1, ANGPT2
30	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.6	PDGFB, CTGF, TNF, ANGPT1, IL1B, IL1A
31	positive regulation of cell migration	GO:030335	9.6	TGFB1, THBS1, EGFR, EDN1, PDGFB, COL1A1
32	platelet activation	GO:030168	9.5	THBS1, TGFB1, SOS1, HGF, TIMP1, PDGFB
33	response to glucocorticoid stimulus	GO:051384	9.5	IL1B, IL6, TNF, SPARC, NGF
34	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.4	TGFB1, TNF, ANGPT1, IL6
35	positive regulation of protein kinase B signaling cascade	GO:051897	9.4	TGFB1, THBS1, EGFR, TNF, ANGPT1
36	activation of MAPK activity	GO:000187	9.3	HGF, THBS1, PTPRC, TNF, IL1B, FGF2
37	positive regulation of smooth muscle cell proliferation	GO:048661	9.3	ELANE, EDN1, PDGFB, TNF, IL6
38	heart development	GO:007507	9.3	TGFBR2, EDN1, PDGFB, SPARC, CASP3, PCNA
39	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	EGFR, EDN1, TNF, IL1B
40	response to hypoxia	GO:001666	9.2	TGFB1, THBS1, EDN1, PDGFB, TNF, ANGPT1
41	cell surface receptor signaling pathway	GO:007166	9.2	EGFR, EDNRB, EDN1, PTPRC, CD36, BSG
42	positive regulation of MAP kinase activity	GO:043406	9.1	TGFB1, ELANE, EGFR, EDN1, PDGFB, TNF
43	blood coagulation	GO:007596	9.0	BSG, HGF, SLC7A5, SOS1, TGFB1, THBS1
44	inflammatory response	GO:006954	8.8	TGFB1, NGF, TNF, HYAL1, IL8, IL6
45	proteolysis	GO:006508	8.8	HGF, TFRC, ELANE, ACE, CTSL1, CTSB
46	response to drug	GO:042493	8.8	TGFBR2, TGFB1, THBS1, TIMP4, ABCB1, EDN1
47	negative regulation of cell proliferation	GO:008285	8.6	TGFB1, TNF, HYAL1, IL8, IL6, IL1B
48	anti-apoptosis	GO:006916	8.6	HGF, THBS1, NGF, TNF, ANGPT1, IL2
49	negative regulation of apoptotic process	GO:043066	8.2	THBS1, TIMP1, EGFR, TNF, CASP3, ANGPT1
50	positive regulation of cell proliferation	GO:008284	7.9	EDN1, EGFR, TIMP1, TGFB1, TGFBR2, PDGFB

Molecular functions related to gingival overgrowth according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen binding	GO:005518	10.2	DCN, DSPP, PDGFB, SPARC, ITGA2
2	metalloendopeptidase inhibitor activity	GO:008191	10.2	TIMP4, TIMP3, TIMP1
3	transforming growth factor beta binding	GO:050431	10.1	TGFBR2, THBS1, CD36
4	(R)-limonene 6-monooxygenase activity	GO:052741	10.0	CYP2C19, CYP2C9
5	(S)-limonene 6-monooxygenase activity	GO:018675	9.9	CYP2C19, CYP2C9
6	(S)-limonene 7-monooxygenase activity	GO:018676	9.7	CYP2C19, CYP2C9
7	heparin binding	GO:008201	9.5	THBS2, THBS1, ELANE, CTGF, PTPRC, FGF7
8	growth factor activity	GO:008083	8.5	FGF2, HGF, NUDT6, TGFB1, PDGFB, NGF
9	cytokine activity	GO:005125	8.1	EDN1, TNF, IL6, IL2, IL1B, IL1A
10	protein binding	GO:005515	4.0	ACE, ABCB1, EGFR, PDGFB, COL1A1, CTSL1