MCID: GNG012
MIFTS: 51

Gingival Overgrowth malady

Gastrointestinal diseases, Oral diseases categories
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Summaries for Gingival Overgrowth

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65Wikipedia, 33MalaCards
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Wikipedia:65 Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia or... more...

MalaCards: Gingival Overgrowth, also known as gingival enlargement nos, is related to periodontitis and arthropathy. An important gene associated with Gingival Overgrowth is NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6), and among its related pathways are Non-integrin membrane-ECM interactions and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds grgdsp and geranylgeranyl pyrophosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Gingival Overgrowth

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

gingival overgrowth 8 10 45 62
gingival enlargement nos 8
gingival enlargement 8
gingival hyperplasia 62


External Ids:

Disease Ontology8 DOID:3086
MeSH35 D019214
ICD1025 K06.1

Related Diseases for Gingival Overgrowth

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to gingival overgrowth

Symptoms for Gingival Overgrowth

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Drugs & Therapeutics for Gingival Overgrowth

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Gingival Overgrowth

Genetic Tests for Gingival Overgrowth

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Anatomical Context for Gingival Overgrowth

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33MalaCards
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MalaCards organs/tissues related to Gingival Overgrowth:

33
Heart, Kidney, Liver, Endothelial, Bone marrow, Bone, Lung

Animal Models for Gingival Overgrowth or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Gingival Overgrowth:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5CTGF, PDGFB, LOX, DCN
2MP:00107717.1CTGF, CTSB, PDGFB, ITGA2, LOX, DCN
3MP:00053766.4DCN, MMP1, LOX, ITGA2, PDGFB, CTSB

Publications for Gingival Overgrowth

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52PubMed
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Articles related to Gingival Overgrowth:

(show top 50)    (show all 388)
idTitleAuthorsYear
1
Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth. (23803025)
2013
2
Can chlorhexidine mouthwash twice daily ameliorate cyclosporine-induced gingival overgrowth? (23473525)
2013
3
Serum cyclophilin A concentrations in renal transplant recipients receiving cyclosporine A: clinical implications for gingival overgrowth. (24035111)
2013
4
Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts. (21883230)
2012
5
Loss of basement membrane integrity in human gingival overgrowth. (21483030)
2011
6
Gingival overgrowth and drug association: a review. (23196317)
2011
7
Surgical management of gingival overgrowth associated with Cowden sydrome: a case report and current understanding. (21519553)
2011
8
Gingival overgrowth secondary to amlodipine. (19749649)
2009
9
Gingival overgrowth in a renal transplant recipient using cyclosporine A. (19040821)
2008
10
Local inflammation exacerbates cyclosporine a-induced gingival overgrowth in rats. (18982435)
2008
11
Expression of fibronectin-binding integrins in gingival epithelium in drug-induced gingival overgrowth. (17305873)
2007
12
Apoptosis and expression of caspase-3 in cyclosporin-induced gingival overgrowth. (18052710)
2007
13
Clinical and pharmacological variables as a risk factor for nifedipine-induced gingival overgrowth. (18265685)
2007
14
The role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowth. (17989122)
2007
15
Apoptosis in gingival overgrowth tissues. (17720861)
2007
16
Demographic, pharmacologic, and periodontal variables for gingival overgrowth in subjects medicated with cyclosporin in the absence of calcium channel blockers. (17274714)
2007
17
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (16670920)
2006
18
Elevated levels of gene expression for collagen and decorin in human gingival overgrowth. (16820039)
2006
19
Gingival overgrowth in renal transplant recipients induced by pharmacological treatment. Review of the literature. (16495873)
2006
20
Increased expression of vascular endothelial growth factor in cyclosporin A-induced gingival overgrowth in rats. (16579703)
2006
21
Apoptosis in cyclosporin A-induced gingival overgrowth: a histological study. (15974838)
2005
22
Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. (15732868)
2004
23
Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin A therapy. (15341348)
2004
24
CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects. (14659971)
2004
25
Connective tissue metabolism and gingival overgrowth. (15187034)
2004
26
Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. (12828653)
2003
27
The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients. (12662462)
2003
28
Cytomegalovirus and cyclosporin-induced gingival overgrowth in children with liver grafts. (12121533)
2002
29
Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1. (12378028)
2002
30
Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation. (12452980)
2002
31
Incidence of phenytoin induced gingival overgrowth in epileptic children: a six month evaluation. (12435021)
2002
32
Immunohistochemical analysis of epidermal growth factor receptor in cyclosporin A-induced gingival overgrowth. (11831486)
2001
33
Upregulation of keratinocyte growth factor in cyclosporin A-induced gingival overgrowth. (11453236)
2001
34
Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. (10052772)
1999
35
Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy. (9667479)
1998
36
Human papillomavirus in a patient with severe gingival overgrowth associated with cyclosporine therapy. A case report. (8724712)
1996
37
Nifedipine-associated gingival overgrowth: a survey of the literature and report of four cases. (9063228)
1996
38
Iatrogenic gingival overgrowth in cardiac transplantation. (7473018)
1995
39
Gingival overgrowth in paediatric cardiac transplant patients: a study of 19 patients aged between 2 and 16 years. (8957834)
1995
40
Dose-dependent gingival overgrowth induced by cyclosporin in rats. (7562351)
1995
41
Altered collagen metabolism in nifedipine-induced gingival overgrowth. (7877076)
1994
42
Periodontal management of nifedipine-induced gingival overgrowth: a case report and review of the pertinent literature. (8779668)
1994
43
Immunohistochemical study of 30 cases of cyclosporin A-induced gingival overgrowth. (7608852)
1994
44
Effect of periodontal treatment on gingival overgrowth among cyclosporine A-treated renal transplant recipients. (8295099)
1993
45
Gingival overgrowth among renal transplant recipients and uraemic patients. (8302465)
1993
46
The incidence and severity of nifedipine-induced gingival overgrowth. (1517474)
1992
47
Phenytoin-induced gingival overgrowth in rats infected with Streptococcus sobrinus 6715. (2151111)
1990
48
The reduction of phenytoin-induced gingival overgrowth in a severely disabled patient: a case report. (2605605)
1989
49
Cyclosporine-induced gingival overgrowth: an ultrastructural stereologic study. (3422723)
1988
50
Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. (3477745)
1987

Variations for Gingival Overgrowth

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Expression for genes affiliated with Gingival Overgrowth

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gingival Overgrowth

Search GEO for disease gene expression data for Gingival Overgrowth.

Pathways for genes affiliated with Gingival Overgrowth

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 30KEGG
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Pathways related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Proteogylcan syndecan-mediated signaling events38
9.5PDGFB, ITGA2
29.5MMP1, DCN
39.4ITGA2, DCN
49.4ITGA2, DCN
5
Show member pathways
9.3NUDT6, PDGFB, CTGF
6
Show member pathways
9.3NUDT6, PDGFB, CTGF
7
Show member pathways
9.3NUDT6, PDGFB, CTGF
8
Show member pathways
9.3NUDT6, PDGFB, CTGF
9
Show member pathways
9.2NUDT6, ITGA2, PDGFB
10
Show member pathways
9.1PDGFB, ITGA2, MMP1
119.1MMP1, ITGA2, PDGFB
12
Show member pathways
8.8NUDT6, ITGA2, PDGFB, CTGF
13
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
14
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
15
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
16
Show member pathways
8.4NUDT6, MMP1, ITGA2, PDGFB, CTGF
17
Show member pathways
7.1CTSB, PDGFB, ITGA2, LOX, MMP1, DCN

Compounds for genes affiliated with Gingival Overgrowth

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1grgdsp459.8ITGA2, MMP1
2geranylgeranyl pyrophosphate459.7MMP1, CTGF
3agar459.5NUDT6, PDGFB, CTGF
4quinacrine45 1110.4LOX, MMP1
5alpha tocopherol459.4CTGF, LOX, MMP1
6prostacyclin459.4CTGF, PDGFB, LOX
7curcumin459.3MMP1, LOX, CTGF
812-hydroxyeicosatetraenoic acid459.3LOX, CTSB
9sodium dodecylsulfate459.3ITGA2, MMP1, DCN
10nacl459.3DCN, ITGA2, CTGF
11prostaglandin459.3MMP1, LOX, CTGF
12pyridoxal45 24 1111.3CTSB, LOX
13glycosaminoglycan459.2DCN, MMP1, LOX
14aspirin45 51 29 2412.1ITGA2, LOX, MMP1
15tgf beta1459.1DCN, MMP1, PDGFB, CTGF
16n acetylcysteine459.0CTGF, LOX, MMP1
17oligonucleotide459.0CTGF, PDGFB, MMP1, DCN
18bleomycin45 1110.0CTGF, PDGFB, LOX, DCN
19ribonucleic acid458.8NUDT6, DCN, MMP1, PDGFB, CTGF
20pd 98,059458.8NUDT6, DCN, MMP1, PDGFB, CTGF
21polyacrylamide458.8DCN, ITGA2, CTSB
22glyceraldehyde 3-phosphate458.7DCN, MMP1, CTSB, CTGF
23creatinine458.7DCN, MMP1, CTSB, CTGF
24heparin45 29 24 1111.6CTGF, CTSB, ITGA2, DCN
25procollagen458.5DCN, MMP1, LOX, PDGFB, CTGF
26h2o2458.5MMP1, LOX, CTSB, CTGF
27arginine458.5NUDT6, DCN, ITGA2, CTSB
28indomethacin45 29 61 1111.5MMP1, LOX, CTSB
29zinc45 249.5DCN, MMP1, PDGFB, CTSB
30fibrinogen458.5CTGF, CTSB, ITGA2
31carbon458.4CTSB, ITGA2, LOX, MMP1
32glutamate458.4CTSB, ITGA2, DCN, NUDT6
33cyclosporin a45 29 6110.3DCN, MMP1, PDGFB, CTSB, CTGF
34thymidine45 249.3NUDT6, LOX, PDGFB, CTSB, CTGF
35lactate458.3CTGF, CTSB, LOX, MMP1, NUDT6
36hydroxyproline45 24 1110.1DCN, MMP1, LOX, CTSB, CTGF
37pge2458.1DCN, MMP1, LOX, CTSB, CTGF
38paraffin458.1DCN, MMP1, LOX, PDGFB, CTSB
39serine457.9NUDT6, DCN, MMP1, PDGFB, CTSB, CTGF
40nitric oxide45 24 119.9NUDT6, DCN, ITGA2, PDGFB, CTSB, CTGF
41cycloheximide457.7MMP1, LOX, ITGA2, PDGFB, CTSB, CTGF
42dexamethasone45 51 29 1110.7DCN, MMP1, LOX, PDGFB, CTSB, CTGF
43estrogen457.7DCN, MMP1, LOX, PDGFB, CTSB, CTGF
44matrigel457.6NUDT6, DCN, MMP1, LOX, ITGA2, CTSB
45oxygen45 248.6DCN, LOX, ITGA2, PDGFB, CTSB, CTGF
46glucose457.3NUDT6, DCN, LOX, ITGA2, PDGFB, CTSB
47tyrosine457.3NUDT6, DCN, LOX, ITGA2, PDGFB, CTSB
48retinoic acid45 248.3NUDT6, DCN, MMP1, LOX, ITGA2, CTSB
49cysteine457.3NUDT6, DCN, MMP1, LOX, ITGA2, CTSB
50vegf456.9CTGF, NUDT6, DCN, MMP1, LOX, ITGA2

GO Terms for genes affiliated with Gingival Overgrowth

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16Gene Ontology
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Cellular components related to Gingival Overgrowth according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484718.8CTGF, CTSB, ITGA2
2extracellular spaceGO:0056157.4DCN, LOX, PDGFB, CTSB, CTGF
3extracellular regionGO:0055767.2CTGF, CTSB, PDGFB, LOX, MMP1, DCN

Biological processes related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1reactive oxygen species metabolic processGO:0725939.9CTGF, PDGFB
2response to woundingGO:0096119.9CTGF, PDGFB
3positive regulation of collagen biosynthetic processGO:0329679.8CTGF, ITGA2
4positive regulation of smooth muscle cell migrationGO:0149119.8ITGA2, PDGFB
5positive regulation of smooth muscle cell proliferationGO:0486619.7ITGA2, PDGFB
6integrin-mediated signaling pathwayGO:0072299.6ITGA2, CTGF
7cell-matrix adhesionGO:0071609.6CTGF, ITGA2
8wound healingGO:0420609.5LOX, DCN
9lung developmentGO:0303249.5CTGF, LOX
10response to estradiolGO:0323559.4CTGF, PDGFB
11blood coagulationGO:0075969.2PDGFB, ITGA2, MMP1
12response to drugGO:0424939.1PDGFB, ITGA2, LOX
13collagen catabolic processGO:0305749.1CTSB, MMP1
14extracellular matrix disassemblyGO:0226179.0CTSB, MMP1, DCN
15extracellular matrix organizationGO:0301987.4CTSB, DCN, MMP1, LOX, ITGA2, PDGFB

Molecular functions related to Gingival Overgrowth according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3CTGF, PDGFB, NUDT6
2collagen bindingGO:0055187.9CTSB, PDGFB, ITGA2, DCN

Products for genes affiliated with Gingival Overgrowth

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Sources for Gingival Overgrowth

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet