MCID: GNG012
MIFTS: 57

Gingival Overgrowth malady

Gastrointestinal diseases category

Summaries for Gingival Overgrowth

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia or... more...

MalaCards: Gingival Overgrowth, also known as gingival enlargement nos, is related to gingivitis and periodontitis. An important gene associated with Gingival Overgrowth is NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Crosslinking of collagen fibrils. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are integument and respiratory system.

Aliases & Classifications for Gingival Overgrowth

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gingival overgrowth 8 10 44 60
gingival enlargement nos 8
gingival enlargement 8
gingival hyperplasia 60


External Ids:

Disease Ontology8 DOID:3086
MeSH34 D019214
ICD1025 K06.1

Related Diseases for Gingival Overgrowth

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17GeneCards, 18GeneDecks
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Diseases related to Gingival Overgrowth via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1gingivitis32.0MMP1, IL1B, IL1A, DSPP, TIMP1
2periodontitis31.2MMP1, MMP3, IL1B, IL1A, CD36, CTSB
3aggressive periodontitis30.4MMP1, IL1A
4leukemia30.4TGFB1, IL1B, IL1A, FGF7, NUDT6, PDGFB
5hyperglycemia30.1TGFB1, CTGF
6pneumonia30.1TGFB1, IL1B, FGF7, CTSB
7arthropathy30.1MMP1, MMP3, IL1B, DCN, TIMP1
8multiple sclerosis30.1TGFB1, IL1B, TIMP1
9myeloma30.0IL1B, CD36, ITGA2
10sarcoma30.0FGF7, PDGFB, LOX
11fibromatosis, gingival30.0TGFB1, MMP1, CD36
12sarcoidosis30.0IL1B, IL1A, DCN, PDGFB
13gingival disease10.4
14acute leukemia10.2
15hypertrichosis10.2
16proteus syndrome10.2
17gingival fibromatosis with hypertrichosis10.2
18hypertrichosis terminalis, generalized, with or without gingival hyperplasia10.2
19bardet-biedl syndrome10.1
20tuberous sclerosis10.1
21cerebritis10.1
22amelogenesis imperfecta10.1
23gingival hypertrophy10.1
24extramedullary plasmacytoma10.1
25cerebral palsy10.1
26cervicitis10.1
27hemolytic anemia10.1
28hodgkin's lymphoma10.1
29plasmacytoma10.1
30acute monocytic leukemia10.0
31fg syndrome10.0
32nocardiosis10.0
33cystinosis10.0
34monocytic leukemia10.0
35multiple myeloma10.0
36amelogenesis imperfecta and gingival fibromatosis syndrome10.0
37recombinant 8 syndrome10.0
38neurofibromatosis10.0
39niemann-pick disease10.0
40klippel-trenaunay syndrome10.0
41ossifying fibroma10.0
42acute myeloid leukemia10.0
43myeloid sarcoma10.0
44chronic lymphocytic leukemia10.0
45epulis10.0
46myeloid leukemia10.0
47neurofibroma10.0
48t-cell leukemia10.0
49moyamoya disease10.0NUDT6
50prostatitis10.0SRD5A1

Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to gingival overgrowth

Clinical Features for Gingival Overgrowth

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Drugs & Therapeutics for Gingival Overgrowth

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Genetic Tests for Gingival Overgrowth

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Anatomical Context for Gingival Overgrowth

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32MalaCards
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MalaCards organs/tissues related to Gingival Overgrowth:

32
Heart, Kidney, Liver, Endothelial, Bone marrow, Bone, Lung

Animal Models for Gingival Overgrowth or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gingival Overgrowth:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.3LOX, COL1A1, PDGFB, CTGF, ITGA2, DCN
2MP:000538810.3LOX, HAS3, CTGF, DCN, TGFB1
3MP:000537910.2ITGA2, DCN, SRD5A1, TGFB1
4MP:000200610.1COL1A1, TIMP1, CTSB, DCN, IL1B, TGFB1
5MP:000537610.1FGF7, LOX, COL1A1, TIMP4, PDGFB, CTGF
6MP:000538510.1LOX, COL1A1, TIMP4, TIMP1, PDGFB, CTGF
7MP:000538710.0COL1A1, TIMP1, PDGFB, CTSB, DCN, CD36
8MP:00107689.9COL1A1, TIMP4, TIMP1, PDGFB, CTGF, CTSB
9MP:00053979.7COL1A1, TIMP1, PDGFB, ITGA2, DCN, CD36

Publications for Gingival Overgrowth

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50PubMed
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Articles related to Gingival Overgrowth:

(show top 50)    (show all 392)
idTitleAuthorsYear
1
Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth. (23803025)
2013
2
Can chlorhexidine mouthwash twice daily ameliorate cyclosporine-induced gingival overgrowth? (23473525)
2013
3
Amlodipine- induced gingival overgrowth: a case report. (23029817)
2012
4
Drug-induced gingival overgrowth: a case report. (22782043)
2012
5
Prevalence of gingival overgrowth among elderly patients under amlodipine therapy at a large Indian teaching hospital. (22506838)
2012
6
Transglutaminase 2 expression is significantly increased in cyclosporine-induced gingival overgrowth. (21938677)
2011
7
Gingival crevicular fluid osteocalcin, N-terminal telopeptides, and calprotectin levels in cyclosporin A-induced gingival overgrowth. (21342006)
2011
8
DIGO: drug-induced gingival overgrowth. Part II: molecular mechanism. (21319676)
2010
9
Down-regulation of transforming growth factor beta-2 expression is associated with the reduction of cyclosporin induced gingival overgrowth in rats treated with roxithromycin: an experimental study. (19995419)
2009
10
Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients. (19718004)
2009
11
Amlodipine-induced gingival overgrowth. (20379416)
2009
12
Differential gene and protein expression of tissue inhibitors of metalloproteinases (TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth. (19450793)
2009
13
Connective tissue growth factors, CTGF and Cyr61 in drug-induced gingival overgrowth--an animal model]. (20209781)
2008
14
Immunohistochemical evaluation of Ki-67 expression and apoptosis in cyclosporin A-induced gingival overgrowth. (17274717)
2007
15
Correlation between finger-prick and venous ciclosporin levels: association with gingival overgrowth and hypertrichosis. (17899211)
2007
16
Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients. (18021981)
2007
17
Expression of transforming growth factor-beta receptor II mRNA in cyclosporine-induced gingival overgrowth. (17112860)
2006
18
Establishment of rat model of drug-induced gingival overgrowth induced by continuous administration of phenytoin. (16006738)
2005
19
Mast cell subpopulations in gingival overgrowth induced by immunosuppressive and nifedipine medication. (15341350)
2004
20
Plasma TGF-beta1 as a risk factor for gingival overgrowth. (15367190)
2004
21
The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients. (12662462)
2003
22
Antibiotic treatment of incipient drug-induced gingival overgrowth in adult renal transplant patients. (12608908)
2003
23
Decreased expression of alpha2 integrin in fibroblasts isolated from cyclosporin A- induced gingival overgrowth in rats. (12941079)
2003
24
Gingival overgrowth in kidney transplant recipients treated with cyclosporine and its relationship with chronic graft nephropathy. (14529900)
2003
25
Cyclosporin A-induced gingival overgrowth in renal transplant patients. (12593596)
2003
26
Superinfecting microorganisms in patients under treatment with cyclosporin-A and its correlation to gingival overgrowth. (12908057)
2003
27
Upregulation of keratinocyte growth factor in cyclosporin A-induced gingival overgrowth. (11453236)
2001
28
Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. (11288789)
2001
29
Cyclosporin A upregulates phospholipase C beta1 in fibroblasts from gingival overgrowth. (11128920)
2000
30
Effects of combined oral treatments with cyclosporine A and nifedipine or diltiazem on drug-induced gingival overgrowth in rats. (10776932)
2000
31
Risk factors for drug-induced gingival overgrowth. (10783833)
2000
32
Clinical and histopathological description of a new case of vigabatrin-induced gingival overgrowth. (11507549)
2000
33
Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth. (10384402)
1999
34
The role of drugs in the pathogenesis of gingival overgrowth. A collective review of current concepts. (10551182)
1999
35
Role of medullasin in nifedipine-induced gingival overgrowth in rats. (9796781)
1998
36
Case report. Use of an argon laser to treat drug-induced gingival overgrowth. (9448349)
1998
37
Medication influencing the development of gingival overgrowth in renal transplant patients. (9723412)
1998
38
Medication induced gingival overgrowth. (9680902)
1998
39
Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients. (9552815)
1997
40
Iatrogenic gingival overgrowth in cardiac transplantation. (7473018)
1995
41
Periodontal management of nifedipine-induced gingival overgrowth: a case report and review of the pertinent literature. (8779668)
1994
42
Amlodipine-induced gingival overgrowth. (8195445)
1994
43
Age dependency of cyclosporin A-induced gingival overgrowth in rats. (8153004)
1993
44
The incidence and severity of nifedipine-induced gingival overgrowth. (1517474)
1992
45
Increased glucocorticoid receptors in diphenylhydantoin induced human gingival overgrowth. (1799368)
1991
46
Gingival overgrowth induced by cyclosporin A in rats. (2372253)
1990
47
Cyclosporine-induced gingival overgrowth: an ultrastructural stereologic study. (3422723)
1988
48
Gingival overgrowth in a patient treated with nifedipine (Procardia). (3470820)
1986
49
Subpopulations of lymphocytes in connective tissue from phenytoin-induced gingival overgrowth. (3868013)
1985
50
Dental root abnormalities and gingival overgrowth in epileptic patients receiving anticonvulsant therapy. (6931209)
1980

Genetic Variations for Gingival Overgrowth

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Expression for genes affiliated with Gingival Overgrowth

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gingival Overgrowth

Search GEO for disease gene expression data for Gingival Overgrowth.

Pathways for genes affiliated with Gingival Overgrowth

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52R&D Systems, 53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
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Pathways related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL1B
210.4LOX, COL1A1
310.4IL1B, IL1A
4
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10.4CD36, TIMP1
5
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10.3NUDT6, PDGFB, TIMP4
610.3FGF7, DCN, ITGA2
710.3TGFB1, IL1B, IL1A
810.3COL1A1, ITGA2, CD36
9
Immune response Bacterial infections in normal airways
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10.3CTSB, IL1A, IL1B
10
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.3IL1B, IL1A, COL1A1
11
Cell adhesion ECM remodeling
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10.3COL1A1, TIMP1, MMP3, MMP1
12
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10.2COL1A1, TIMP1, CTSB, MMP3
13
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10.2TIMP4, TIMP1, MMP3, MMP1
1410.2ITGA2, CD36, IL1A, IL1B
15
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10.2TIMP1, PDGFB, CTGF, NUDT6, FGF7
1610.2PDGFB, ITGA2, FGF7, MMP1, TGFB1
17
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10.2CD36, DCN, ITGA2, PDGFB, COL1A1
18
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10.2TIMP4, PDGFB, CTGF, NUDT6, FGF7
19
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10.2COL1A1, ITGA2, CD36, MMP3, MMP1
20
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10.2CD36, ITGA2, PDGFB, TIMP1, COL1A1
21
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10.2PDGFB, FGF7, IL1A, IL1B, TGFB1
22
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10.2TIMP1, PDGFB, CTGF, NUDT6, FGF7, TGFB1
23
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10.1IL1B, IL1A, FGF7, CD36, CTSB, PDGFB
24
Hide members
10.1COL1A1, TIMP4, PDGFB, CTGF, ITGA2, NUDT6
25
Hide members
10.1TIMP4, TIMP1, PDGFB, CTGF, NUDT6, FGF7
26
Hide members
10.1IL1B, TIMP4, TIMP1, PDGFB, CTGF, NUDT6
27
Hide members
10.0COL1A1, TIMP4, TIMP1, PDGFB, CTGF, ITGA2
28
Hide members
10.0LOX, COL1A1, TIMP1, PDGFB, CTSB, ITGA2
29
Hide members
10.0TIMP4, TIMP1, PDGFB, CTGF, ITGA2, NUDT6
30
Hide members
9.9CTGF, PDGFB, TIMP1, TIMP4, ITGA2, NUDT6
31
Hide members
9.9CTGF, PDGFB, TIMP1, TIMP4, ITGA2, NUDT6
32
Hide members
9.9TIMP4, TIMP1, PDGFB, CTGF, ITGA2, NUDT6

Compounds for genes affiliated with Gingival Overgrowth

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1procollagen4410.9TGFB1
2estrogen4410.9SRD5A1
3pge24410.8TGFB1, COL1A1
4cycloheximide4410.8PDGFB, FGF7
5alginate4410.7DCN, CD36
6indomethacin44 59 28 1113.7LOX, CTSB, SRD5A1
7hydrocortisone44 2 59 1113.6HAS3, MMP1
8cyclosporin a44 28 5912.6DCN, CTSB, MMP1, FGF7, PDGFB, CTGF
9uva 14410.6MMP3, MMP1, TIMP1, IL1A
10doxycycline44 1111.6DSPP, NUDT6, MMP1, FGF7, MMP3
11(4-aminophenyl)mercuric acetate4410.6MMP3, TIMP1
12prostaglandin4410.5MMP3, LOX, IL1A, MMP1, IL1B
13matrigel4410.5CTSB, LOX, ITGA2, DCN, NUDT6, MMP1
14minocycline44 1111.5IL1A, SRD5A1, IL1B, TIMP1, DSPP
15rantes4410.5IL1A, IL1B, TGFB1, FGF7
16alendronate44 49 1112.5TIMP1, DSPP, MMP1, MMP3, CD36
17vitamin d4410.5COL1A1, CD36, FGF7, MMP3, SRD5A1, DSPP
18ns 39844 5911.5MMP1, IL1B, IL1A, LOX, TGFB1
19bleomycin44 1111.5LOX, COL1A1, TIMP1, PDGFB, CTGF, TGFB1
20hydroxyproline44 11 2412.5TGFB1, LOX, COL1A1, TIMP1, CTGF, CTSB
21dexamethasone44 49 28 1113.4HAS3, PDGFB, TIMP1, COL1A1, LOX, CTGF
22curcumin4410.4TGFB1, MMP1, MMP3, IL1B, IL1A, TIMP1
23sb 20358044 5911.4TGFB1, TIMP1, CTGF, CD36, IL1A, IL1B
24lactate4410.4MMP1, MMP3, TGFB1, CTGF, TIMP1, LOX
25calcitriol44 59 11 2413.4MMP1, IL1B, IL1A, CD36, TIMP1, TGFB1
26pd 98,0594410.4MMP3, TGFB1, MMP1, IL1B, FGF7, NUDT6
27polyglycolic acid4410.4FGF7, DSPP, PDGFB
28tgf beta14410.4MMP1, FGF7, CD36, DCN, CTGF, PDGFB
29paraffin4410.4PDGFB, CTSB, DCN, DSPP, MMP3, MMP1
30serine4410.4FGF7, TGFB1, MMP3, TIMP1, PDGFB, CTGF
31cytochalasin d44 5911.3CD36, MMP3, MMP1, TGFB1, TIMP1, CTGF
32nitric oxide44 11 2412.3TIMP1, CTGF, IL1A, PDGFB, CTSB, ITGA2
33thymidine44 2411.3LOX, FGF7, TGFB1, IL1B, IL1A, CTGF
34hyaluronic acid44 2411.3TGFB1, MMP1, MMP3, IL1B, IL1A, FGF7
35heparin44 28 11 2413.3CD36, CTGF, DCN, CTSB, ITGA2, FGF7
36genistein44 28 59 2 11 2415.3TIMP1, DCN, CD36, IL1B, MMP3, MMP1
3712-o-tetradecanoylphorbol 13-acetate4410.3MMP3, TIMP1, ITGA2, FGF7, IL1A, MMP1
38aspartate4410.3FGF7, COL1A1, DCN, DSPP, IL1A
39ribonucleic acid4410.3COL1A1, TIMP1, PDGFB, TGFB1, MMP1, MMP3
40glycosaminoglycan4410.3TGFB1, MMP1, MMP3, IL1A, FGF7, CD36
41h2o24410.3CD36, FGF7, IL1A, MMP1, DSPP, CTSB
42creatinine4410.3CD36, IL1A, TGFB1, DCN, CTSB, MMP3
43glutamine4410.3CTSB, TIMP1, TGFB1, SRD5A1, FGF7, CD36
44cysteine4410.2LOX, COL1A1, TIMP1, CTGF, CTSB, ITGA2
45glyceraldehyde 3-phosphate4410.2MMP1, TIMP1, CTGF, CTSB, DCN, MMP3
46carbon4410.2LOX, CTSB, MMP1, DSPP, ITGA2, TIMP1
47pirfenidone44 5911.1IL1B, CD36, IL1A, TGFB1
48vegf4410.0TGFB1, SRD5A1, MMP1, MMP3, IL1B, LOX
49retinoic acid44 2411.0MMP3, MMP1, SRD5A1, IL1B, IL1A, FGF7
50prostacyclin449.9CTGF, IL1A, IL1B, PDGFB, TIMP1, LOX

GO Terms for genes affiliated with Gingival Overgrowth

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16Gene Ontology
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Cellular components related to Gingival Overgrowth according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3TGFB1, PDGFB, TIMP1
2proteinaceous extracellular matrixGO:0055789.9CTGF, DSPP, MMP3, MMP1, TGFB1
3extracellular spaceGO:0056159.8LOX, COL1A1, TIMP4, PDGFB, CTGF, CTSB
4extracellular regionGO:0055769.7TGFB1, LOX, COL1A1, TIMP4, TIMP1, PDGFB

Biological processes related to Gingival Overgrowth according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.6IL1B, IL1A
2response to woundingGO:00961110.6PDGFB, CTGF, FGF7, TGFB1
3positive regulation vascular endothelial growth factor productionGO:01057510.6TGFB1, IL1B, IL1A
4positive regulation of mitosisGO:04584010.6PDGFB, IL1A, IL1B
5collagen catabolic processGO:03057410.6MMP1, MMP3, CTSB, COL1A1
6extracellular matrix assemblyGO:08502910.6HAS3, TGFB1
7response to peptide hormone stimulusGO:04343410.6COL1A1, TIMP4, TIMP1, CTGF
8platelet degranulationGO:00257610.6TIMP1, PDGFB, CD36, TGFB1
9extracellular matrix disassemblyGO:02261710.5MMP1, MMP3, CTSB, TIMP1, COL1A1
10positive regulation of cell divisionGO:05178110.5PDGFB, FGF7, IL1A, IL1B, TGFB1
11hyaluronan biosynthetic processGO:03021310.5HAS3, IL1B
12response to estradiol stimulusGO:03235510.5TGFB1, CTGF, PDGFB
13platelet activationGO:03016810.5COL1A1, TIMP1, PDGFB, CD36, TGFB1
14positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5PDGFB, CD36, FGF7
15positive regulation of chemotaxisGO:05092110.4TGFB1, PDGFB
16positive regulation of cell proliferationGO:00828410.4TIMP1, PDGFB, CTGF, FGF7, TGFB1
17blood coagulationGO:00759610.4COL1A1, TIMP1, PDGFB, ITGA2, CD36, MMP1
18positive regulation of protein phosphorylationGO:00193410.3CTGF, IL1B, TGFB1
19extracellular matrix organizationGO:03019810.3TGFB1, LOX, COL1A1, TIMP1, PDGFB, CTSB
20agingGO:00756810.3TGFB1, DCN, TIMP1
21positive regulation of transcription, DNA-dependentGO:04589310.3TGFB1, IL1B, HAS3, PDGFB, COL1A1
22response to drugGO:04249310.2TGFB1, PDGFB, TIMP4, LOX
23branching involved in salivary gland morphogenesisGO:06044510.1PDGFB, FGF7

Molecular functions related to Gingival Overgrowth according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.4PDGFB, COL1A1
2collagen bindingGO:00551810.2DSPP, DCN, ITGA2, PDGFB
3growth factor activityGO:0080839.9PDGFB, CTGF, NUDT6, FGF7, TGFB1

Products for genes affiliated with Gingival Overgrowth

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Sources for Gingival Overgrowth

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet