MCID: GNG012
MIFTS: 44

Gingival Overgrowth malady

Gastrointestinal diseases category

Summaries for Gingival Overgrowth

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Wikipedia:63 Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia,... more...

MalaCards based summary: Gingival Overgrowth, also known as gingival enlargement nos, is related to periodontitis and arthropathy. An important gene associated with Gingival Overgrowth is NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6), and among its related pathways are Non-integrin membrane-ECM interactions and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds grgdsp and geranylgeranyl pyrophosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Gingival Overgrowth

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 25ICD10
See all sources

Gingival Overgrowth, Aliases & Descriptions:

Name: Gingival Overgrowth 9 11 43
Gingival Enlargement Nos 9
 
Gingival Enlargement 9
Gingival Hyperplasia 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:3086
MeSH33 D019214
ICD1025 K06.1

Related Diseases for Gingival Overgrowth

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Diseases related to Gingival Overgrowth via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.3CTSB, MMP1
2arthropathy30.3MMP1, DCN
3keloids29.9CTGF, LOX, MMP1, DCN
4gingivitis11.4
5leukemia10.3
6hypertrichosis10.3
7endotheliitis10.3
8vitreoretinopathy, neovascular inflammatory10.3CTGF, NUDT6
9aggressive periodontitis10.3
10chronic ulcer of skin10.3PDGFB, MMP1
11robinow syndrome, autosomal dominant10.3
12zimmermann-laband syndrome10.3
13raine syndrome10.3
14robinow syndrome, autosomal recessive10.3
15lathosterolosis10.3
16multicentric osteolysis, nodulosis, and arthropathy10.3
17marshall-smith syndrome10.3
18amelogenesis imperfecta, type ig10.3
19mannosidosis, alpha-, types i and ii10.3
20juvenile hyaline fibromatosis10.3
21renal fibrosis10.2PDGFB, CTGF
22acute myelomonocytic leukemia10.2
23odontogenic myxoma10.2
24abdominal aortic aneurysm10.2DCN, MMP1
25oral submucous fibrosis10.2MMP1, LOX
26myopia10.2NUDT6, DCN
27connective tissue disease10.1CTGF, LOX
28marfan syndrome10.1LOX, DCN
29nephritis10.1CTGF, PDGFB
30pulmonary fibrosis, idiopathic10.1CTGF, PDGFB, MMP1
31craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome10.1
32pelger-huet anomaly10.1
33ehlers-danlos syndrome, type iii10.1
34gm1-gangliosidosis, type i10.1
35c syndrome10.1
36hyaline fibromatosis syndrome10.1
37aspartylglucosaminuria10.1
38williams-beuren syndrome10.1
39bent bone dysplasia syndrome10.1
40smith-lemli-opitz syndrome10.1
41haim-munk syndrome10.1
42ehlers-danlos syndrome, type viii10.1
43congenital disorder of glycosylation, type iia10.1
44cleft palate, isolated10.1
45hennekam lymphangiectasia-lymphedema syndrome 110.1
46multiple congenital anomalies-hypotonia-seizures syndrome 210.1
47fibromatosis, gingival10.1
48ehlers-danlos syndrome, type iv10.1
49plasminogen deficiency, type i10.1
50mucopolysaccharidosis ih10.1

Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to gingival overgrowth

Symptoms for Gingival Overgrowth

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Drugs & Therapeutics for Gingival Overgrowth

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Drug clinical trials:

Search ClinicalTrials for Gingival Overgrowth

Search NIH Clinical Center for Gingival Overgrowth

Genetic Tests for Gingival Overgrowth

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Anatomical Context for Gingival Overgrowth

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MalaCards organs/tissues related to Gingival Overgrowth:

31
Heart, Kidney, Liver, Endothelial, Bone marrow, Bone, Lung

Animal Models for Gingival Overgrowth or affiliated genes

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MGI Mouse Phenotypes related to Gingival Overgrowth:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5CTGF, PDGFB, LOX, DCN
2MP:00107717.1CTGF, CTSB, PDGFB, ITGA2, LOX, DCN
3MP:00053766.4DCN, MMP1, LOX, ITGA2, PDGFB, CTSB

Publications for Gingival Overgrowth

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Articles related to Gingival Overgrowth:

(show top 50)    (show all 409)
idTitleAuthorsYear
1
Are antimicrobial peptides related to cyclosporine A-induced gingival overgrowth? (25555253)
2015
2
Is periodontal health a predictor of drug-induced gingival overgrowth? A cross-sectional study. (25426150)
2014
3
Gingival overgrowth as secondary effect of calcium channel blockers administration. A case report. (25408733)
2014
4
Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth. (24581850)
2014
5
Comprehensive mutation analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 genes is suggestive of a non- neoplastic nature of phenytoin induced gingival overgrowth. (23803025)
2013
6
Can chlorhexidine mouthwash twice daily ameliorate cyclosporine-induced gingival overgrowth? (23473525)
2013
7
Serum cyclophilin A concentrations in renal transplant recipients receiving cyclosporine A: clinical implications for gingival overgrowth. (24035111)
2013
8
Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts. (21883230)
2012
9
Loss of basement membrane integrity in human gingival overgrowth. (21483030)
2011
10
Gingival overgrowth and drug association: a review. (23196317)
2011
11
Surgical management of gingival overgrowth associated with Cowden sydrome: a case report and current understanding. (21519553)
2011
12
Gingival overgrowth secondary to amlodipine. (19749649)
2009
13
Gingival overgrowth in a renal transplant recipient using cyclosporine A. (19040821)
2008
14
Local inflammation exacerbates cyclosporine a-induced gingival overgrowth in rats. (18982435)
2008
15
Expression of fibronectin-binding integrins in gingival epithelium in drug-induced gingival overgrowth. (17305873)
2007
16
Apoptosis and expression of caspase-3 in cyclosporin-induced gingival overgrowth. (18052710)
2007
17
Clinical and pharmacological variables as a risk factor for nifedipine-induced gingival overgrowth. (18265685)
2007
18
The role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowth. (17989122)
2007
19
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (16670920)
2006
20
Elevated levels of gene expression for collagen and decorin in human gingival overgrowth. (16820039)
2006
21
Gingival overgrowth in renal transplant recipients induced by pharmacological treatment. Review of the literature. (16495873)
2006
22
Increased expression of vascular endothelial growth factor in cyclosporin A-induced gingival overgrowth in rats. (16579703)
2006
23
Apoptosis in cyclosporin A-induced gingival overgrowth: a histological study. (15974838)
2005
24
Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. (15732868)
2004
25
Relationship of subgingival and salivary microbiota to gingival overgrowth in heart transplant patients following cyclosporin A therapy. (15341348)
2004
26
CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects. (14659971)
2004
27
Connective tissue metabolism and gingival overgrowth. (15187034)
2004
28
Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. (12828653)
2003
29
The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients. (12662462)
2003
30
Cytomegalovirus and cyclosporin-induced gingival overgrowth in children with liver grafts. (12121533)
2002
31
Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1. (12378028)
2002
32
Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation. (12452980)
2002
33
Immunohistochemical analysis of epidermal growth factor receptor in cyclosporin A-induced gingival overgrowth. (11831486)
2001
34
Upregulation of keratinocyte growth factor in cyclosporin A-induced gingival overgrowth. (11453236)
2001
35
Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. (10052772)
1999
36
Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy. (9667479)
1998
37
Human papillomavirus in a patient with severe gingival overgrowth associated with cyclosporine therapy. A case report. (8724712)
1996
38
Nifedipine-associated gingival overgrowth: a survey of the literature and report of four cases. (9063228)
1996
39
Iatrogenic gingival overgrowth in cardiac transplantation. (7473018)
1995
40
Gingival overgrowth in paediatric cardiac transplant patients: a study of 19 patients aged between 2 and 16 years. (8957834)
1995
41
Dose-dependent gingival overgrowth induced by cyclosporin in rats. (7562351)
1995
42
Altered collagen metabolism in nifedipine-induced gingival overgrowth. (7877076)
1994
43
Periodontal management of nifedipine-induced gingival overgrowth: a case report and review of the pertinent literature. (8779668)
1994
44
Immunohistochemical study of 30 cases of cyclosporin A-induced gingival overgrowth. (7608852)
1994
45
Effect of periodontal treatment on gingival overgrowth among cyclosporine A-treated renal transplant recipients. (8295099)
1993
46
Gingival overgrowth among renal transplant recipients and uraemic patients. (8302465)
1993
47
The incidence and severity of nifedipine-induced gingival overgrowth. (1517474)
1992
48
The reduction of phenytoin-induced gingival overgrowth in a severely disabled patient: a case report. (2605605)
1989
49
Cyclosporine-induced gingival overgrowth: an ultrastructural stereologic study. (3422723)
1988
50
Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. (3477745)
1987

Variations for Gingival Overgrowth

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Expression for genes affiliated with Gingival Overgrowth

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Search GEO for disease gene expression data for Gingival Overgrowth.

Pathways for genes affiliated with Gingival Overgrowth

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Pathways related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Proteogylcan syndecan-mediated signaling events36
9.5PDGFB, ITGA2
29.5MMP1, DCN
39.4ITGA2, DCN
49.4ITGA2, DCN
5
Show member pathways
9.3NUDT6, PDGFB, CTGF
6
Show member pathways
9.3NUDT6, PDGFB, CTGF
7
Show member pathways
9.3NUDT6, PDGFB, CTGF
8
Show member pathways
9.3NUDT6, PDGFB, CTGF
9
Show member pathways
9.2NUDT6, ITGA2, PDGFB
10
Show member pathways
9.1PDGFB, ITGA2, MMP1
119.1MMP1, ITGA2, PDGFB
12
Show member pathways
8.8NUDT6, ITGA2, PDGFB, CTGF
13
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
14
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
15
Show member pathways
8.8CTGF, PDGFB, ITGA2, NUDT6
16
Show member pathways
8.4NUDT6, MMP1, ITGA2, PDGFB, CTGF
17
Show member pathways
7.1CTSB, PDGFB, ITGA2, LOX, MMP1, DCN

Compounds for genes affiliated with Gingival Overgrowth

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Compounds related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1grgdsp439.8MMP1, ITGA2
2geranylgeranyl pyrophosphate439.7MMP1, CTGF
3agar439.5NUDT6, PDGFB, CTGF
4quinacrine43 1210.4LOX, MMP1
5alpha tocopherol439.4LOX, CTGF, MMP1
6prostacyclin439.4LOX, PDGFB, CTGF
7curcumin439.3MMP1, CTGF, LOX
812-hydroxyeicosatetraenoic acid439.3LOX, CTSB
9sodium dodecylsulfate439.3DCN, MMP1, ITGA2
10nacl439.3DCN, CTGF, ITGA2
11prostaglandin439.3MMP1, CTGF, LOX
12pyridoxal43 24 1211.3LOX, CTSB
13glycosaminoglycan439.2MMP1, DCN, LOX
14aspirin43 49 28 2412.1ITGA2, MMP1, LOX
15tgf beta1439.1MMP1, CTGF, PDGFB, DCN
16n acetylcysteine439.0CTGF, LOX, MMP1
17oligonucleotide439.0MMP1, DCN, CTGF, PDGFB
18bleomycin43 1210.0PDGFB, CTGF, DCN, LOX
19ribonucleic acid438.8NUDT6, DCN, CTGF, PDGFB, MMP1
20pd 98,059438.8CTGF, NUDT6, PDGFB, MMP1, DCN
21polyacrylamide438.8ITGA2, DCN, CTSB
22glyceraldehyde 3-phosphate438.7CTSB, CTGF, MMP1, DCN
23creatinine438.7CTGF, CTSB, MMP1, DCN
24heparin43 28 24 1211.6DCN, CTSB, CTGF, ITGA2
25procollagen438.5CTGF, PDGFB, MMP1, DCN, LOX
26h2o2438.5MMP1, CTSB, CTGF, LOX
27arginine438.5NUDT6, CTSB, ITGA2, DCN
28indomethacin43 28 59 1211.5LOX, CTSB, MMP1
29zinc43 249.5DCN, MMP1, PDGFB, CTSB
30fibrinogen438.5CTGF, ITGA2, CTSB
31carbon438.4CTSB, MMP1, LOX, ITGA2
32glutamate438.4CTSB, ITGA2, NUDT6, DCN
33cyclosporin a43 28 5910.3DCN, MMP1, PDGFB, CTSB, CTGF
34thymidine43 249.3CTGF, CTSB, PDGFB, LOX, NUDT6
35lactate438.3LOX, CTSB, CTGF, MMP1, NUDT6
36hydroxyproline43 24 1210.1LOX, CTSB, DCN, CTGF, MMP1
37pge2438.1DCN, LOX, MMP1, CTGF, CTSB
38paraffin438.1PDGFB, LOX, MMP1, DCN, CTSB
39serine437.9PDGFB, MMP1, CTSB, CTGF, DCN, NUDT6
40nitric oxide43 24 129.9NUDT6, DCN, ITGA2, PDGFB, CTSB, CTGF
41cycloheximide437.7LOX, ITGA2, PDGFB, CTGF, MMP1, CTSB
42dexamethasone43 49 28 1210.7LOX, PDGFB, MMP1, DCN, CTSB, CTGF
43estrogen437.7PDGFB, LOX, CTGF, CTSB, DCN, MMP1
44matrigel437.6CTSB, NUDT6, MMP1, LOX, ITGA2, DCN
45oxygen43 248.6LOX, DCN, ITGA2, PDGFB, CTSB, CTGF
46glucose437.3CTSB, PDGFB, ITGA2, NUDT6, LOX, DCN
47tyrosine437.3DCN, LOX, ITGA2, PDGFB, CTSB, CTGF
48retinoic acid43 248.3LOX, DCN, CTGF, CTSB, ITGA2, MMP1
49cysteine437.3CTGF, CTSB, ITGA2, LOX, MMP1, NUDT6
50vegf436.9PDGFB, NUDT6, DCN, MMP1, LOX, ITGA2

GO Terms for genes affiliated with Gingival Overgrowth

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Cellular components related to Gingival Overgrowth according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:00484718.8CTGF, CTSB, ITGA2
2extracellular spaceGO:00056157.4DCN, LOX, PDGFB, CTSB, CTGF
3extracellular regionGO:00055767.2CTGF, CTSB, PDGFB, LOX, MMP1, DCN

Biological processes related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1reactive oxygen species metabolic processGO:00725939.9CTGF, PDGFB
2response to woundingGO:00096119.9CTGF, PDGFB
3positive regulation of collagen biosynthetic processGO:00329679.8CTGF, ITGA2
4positive regulation of smooth muscle cell migrationGO:00149119.8ITGA2, PDGFB
5positive regulation of smooth muscle cell proliferationGO:00486619.7ITGA2, PDGFB
6integrin-mediated signaling pathwayGO:00072299.6ITGA2, CTGF
7cell-matrix adhesionGO:00071609.6CTGF, ITGA2
8wound healingGO:00420609.5LOX, DCN
9lung developmentGO:00303249.5CTGF, LOX
10response to estradiolGO:00323559.4CTGF, PDGFB
11blood coagulationGO:00075969.2PDGFB, ITGA2, MMP1
12response to drugGO:00424939.1PDGFB, ITGA2, LOX
13collagen catabolic processGO:00305749.1CTSB, MMP1
14extracellular matrix disassemblyGO:00226179.0CTSB, MMP1, DCN
15extracellular matrix organizationGO:00301987.4CTSB, DCN, MMP1, LOX, ITGA2, PDGFB

Molecular functions related to Gingival Overgrowth according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.3CTGF, PDGFB, NUDT6
2collagen bindingGO:00055187.9CTSB, PDGFB, ITGA2, DCN

Products for genes affiliated with Gingival Overgrowth

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Sources for Gingival Overgrowth

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet