MCID: GNG003
MIFTS: 45

Gingival Recession

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Gingival Recession

MalaCards integrated aliases for Gingival Recession:

Name: Gingival Recession 37 12 51 41 14 69
Localized Gingival Recession 12 69
Gingival Recession, Unspecified 12
Gingival Recession, Localized 12
Moderate Gingival Recession 12
Gingival Recession, Minimal 69
Minimal Gingival Recession 12
Gingival Recession, Severe 69
Severe Gingival Recession 12
Gingival Recession Nos 12

Classifications:



Summaries for Gingival Recession

MalaCards based summary : Gingival Recession, also known as localized gingival recession, is related to ehlers-danlos syndrome, periodontal type, 1 and gingivitis. An important gene associated with Gingival Recession is C1R (Complement C1r), and among its related pathways/superpathways are Complement Pathway and Pertussis. The drugs Acetaminophen and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and tongue.

Wikipedia : 72 Gingival recession, also known as receding gums, is the exposure in the roots of the teeth caused by a... more...

Related Diseases for Gingival Recession

Graphical network of the top 20 diseases related to Gingival Recession:



Diseases related to Gingival Recession

Symptoms & Phenotypes for Gingival Recession

Drugs & Therapeutics for Gingival Recession

Drugs for Gingival Recession (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 120)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Epinephrine Approved, Vet_approved Phase 4,Early Phase 1 51-43-4 5816
5
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
6 Racepinephrine Approved Phase 4,Early Phase 1 329-65-7
7
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
8
Menthol Approved Phase 4 2216-51-5 16666
9
Lidocaine Approved, Vet_approved Phase 4,Early Phase 1 137-58-6 3676
10
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
11 Coagulants Phase 4
12 Gelatin Sponge, Absorbable Phase 4
13 Hemostatics Phase 4
14 Analgesics Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Anti-Infective Agents Phase 4,Phase 2
17 Anti-Infective Agents, Local Phase 4
18 Antipyretics Phase 4
19 Chlorhexidine gluconate Phase 4
20 Dermatologic Agents Phase 4
21 Disinfectants Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 2
23 Adrenergic Agents Phase 4
24 Adrenergic Agonists Phase 4
25 Adrenergic alpha-Agonists Phase 4
26 Adrenergic beta-Agonists Phase 4
27 Anesthetics Phase 4,Early Phase 1
28 Anesthetics, Local Phase 4
29 Anti-Asthmatic Agents Phase 4
30 Antiemetics Phase 4
31 Anti-Inflammatory Agents Phase 4
32 Antineoplastic Agents, Hormonal Phase 4
33 Autonomic Agents Phase 4,Phase 2
34 BB 1101 Phase 4
35 Bronchodilator Agents Phase 4
36 Central Nervous System Depressants Phase 4
37 Dexamethasone acetate Phase 4 1177-87-3
38 Epinephryl borate Phase 4,Early Phase 1
39 Gastrointestinal Agents Phase 4
40 glucocorticoids Phase 4
41 HIV Protease Inhibitors Phase 4
42 Hormone Antagonists Phase 4
43 Hormones Phase 4
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
45 Mydriatics Phase 4
46 Neurotransmitter Agents Phase 4,Phase 2
47
protease inhibitors Phase 4
48 Respiratory System Agents Phase 4,Phase 2
49 Vasoconstrictor Agents Phase 4
50 Anti-Bacterial Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 155)

# Name Status NCT ID Phase Drugs
1 Pinhole Surgical Technique With And Without Use Of Buttons For Treatment Of Multiple Gingival Recessions: RCT Unknown status NCT02632968 Phase 4
2 Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects Unknown status NCT01440426 Phase 4
3 Laser De-epithelialization for Epithelial Exclusion in Root Coverage Procedure: a Clinical Study Unknown status NCT02626117 Phase 4
4 Platelet Rich Fibrin in the Treatment of Palatal Wounds Unknown status NCT02438046 Phase 4
5 Semilunar Coronally Positioned Flap With or Without Enamel Matrix Derivative for the Treatment of Gingival Recessions Completed NCT02459704 Phase 4
6 Treatment of Multiple Gingival Recessions Completed NCT02818855 Phase 4 Collagen Matrix
7 Clinical Evaluation of Single-stage Advanced Versus Rotated Flaps in the Treatment of Gingival Recessions Completed NCT02433912 Phase 4 750 mg paracetamol;chlorhexidine gluconate
8 Xenogenous Collagen Matrix Graft With or Without Enamel Matrix Proteins Derivative for Root Coverage Completed NCT02456337 Phase 4
9 Gingival Recession Coverage With and Without Emdogain Completed NCT02230787 Phase 4
10 Coronally Advanced Flap and PRF With or Without Demineralized Freeze-dried Bone Allograft in Gingival Recession Completed NCT02835430 Phase 4
11 Coronally Advanced Flap With or Without Porcine Collagen Matrix for Root Coverage Completed NCT02242500 Phase 4
12 Coronally Advanced Flap in Combination With Acellular Dermal Matrix and Enamel Matrix Derivatives for Root Coverage Completed NCT00720707 Phase 4
13 Effect of Low-level Laser Therapy on Palatal Wound Healing Completed NCT02239042 Phase 4
14 Evaluation of the Inflammatory and Healing Profile After Root Coverage With Emdogain® Completed NCT03059966 Phase 4
15 Tunnel With and Without Intramucosal Vertical Incisions Completed NCT02486991 Phase 4
16 Microsurgical Versus Conventional Semilunar Coronally Advanced Flap Completed NCT02433899 Phase 4 Dexamethasone;Chlorhexidine gluconate;2.0% Mepivacaine + 1:100.000 epinephrine
17 Impact of Soft Tissue Grafts on Tissue Alterations After Immediate Tooth Replacement Completed NCT02922075 Phase 4 Post operative medication
18 Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial. Completed NCT02102360 Phase 4
19 Regenerative Surgical Treatment of Peri-implantitis Completed NCT02500654 Phase 4
20 A Clinical Trial Testing Root Coverage With Acellular Dermal Matrix in Thin and Thick Gingival Biotypes Recruiting NCT03057730 Phase 4
21 Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY Suspended NCT02863744 Phase 4
22 Coronally Advanced Flap With Connective Tissue Graft and PRF for Recession Coverage Completed NCT03023995 Phase 3
23 Effect of Low-Level Laser on Pain and Healing of Donor Site Following Free Gingival Graft Completed NCT02896283 Phase 2, Phase 3
24 Safety and Efficacy of Gintuit(TM)for Oral Soft Tissue Regeneration Completed NCT00587834 Phase 3
25 Efficacy and Safety of PERIOGEN in the Treatment of Periodontal Bone Defect Completed NCT00496847 Phase 3 PERIOGEN;Beta TCP alone
26 Cervical Restorations Placed Under Two Isolation Methods Completed NCT01506830 Phase 2, Phase 3
27 Comparison Between Two Coronally Positioned Flap With Connective Tissue Unknown status NCT01814592 Phase 2
28 Root Coverage in Smokers With Acellular Dermal Matrix Graft and Enamel Matrix Derivative Completed NCT02135471 Phase 2 acellular dermal matrix graft;enamel matrix derivative
29 Regeneration of Human Intrabony Defects With rhFGF-2/HA Completed NCT02337166 Phase 1, Phase 2
30 Comparison Of Clinical Efficacy Of A Herbal And A Non-Herbal Mouthwash On Dentinal Hypersensitivity Completed NCT02008500 Phase 2
31 Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use Completed NCT00218270 Phase 2 Tobacco free snuff
32 A Clinical Trial of YH14642 in Patients With Chronic Periodontal Disease Completed NCT01499225 Phase 2 YH14642 500mg Tab;YH14642 500mg Tab;YH14642 500mg Tab;INSADOL[Zea mays L. extract] 35mg Tab;DENTISTA[Doxycycline hyclate] 20mg Cap;Placebo
33 A Phase II Clinical Trial of YH23537 in Patients With Chronic Periodontal Disease. Active, not recruiting NCT02585596 Phase 2 YH23537 1000mg/day;YH23537 2000mg/day;YH23537 3000mg/day;placebo
34 Comparison of Root Coverage of Gingival Recessions Not yet recruiting NCT02980055 Phase 2
35 A Pilot Study of CelTx(TM) (Apligraf®) in the Treatment of Gingival Recession Requiring Root Coverage Terminated NCT00679081 Phase 1, Phase 2
36 Root Coverage Using a Xenograph for Treatment of Gingival Recession Completed NCT02657395 Phase 1
37 Use of a Collagen Membrane for Soft Tissue Grafting Completed NCT02206009 Phase 1
38 A Modified Tunnel Approach in Treatment of Gingival Recession Unknown status NCT02642887
39 Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Unknown status NCT02581319
40 The Role of Immediate Provisional Restorations on Bone Level Implants Unknown status NCT00906165
41 A Novel Volumetric Analysis Using CAD/CAM Scanners in Gingival Recession Treatment Completed NCT03295604
42 Platelet-Rich Fibrin in the Treatment of Multiple Gingival Recessions Completed NCT02335866 Early Phase 1
43 Non-Pedicled Buccal Fat Pad Graft in the Treatment of Gingival Recessions Completed NCT02393053
44 Treatment of Gingival Recession-type Defects Using Different Restorative Materials Completed NCT02788266
45 Clinical Comparison Between Two Surgical Techniques for the Treatment of Gingival Recessions Completed NCT01175720
46 Cytokine and MMP Levels in Gingival Crevicular Fluid in the Treatment of Localized Gingival Recessions Completed NCT02380872
47 Gingival Recession Treatment With Concentrated Growth Factor(CGF) Completed NCT03020732
48 Titanium Prepared Platelet Rich Fibrin for Multiple Gingival Recessions Completed NCT03121872
49 Effectiveness of Adjunctive Hyaluronic Acid Application in Coronally Advanced Flap in Single Gingival Recession Sites Completed NCT03204565
50 The Use of Mucograft® to Treat Gingival Recession Completed NCT02986191

Search NIH Clinical Center for Gingival Recession

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Gingival Recession cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Gingival Recession:
Adipose-derived vascular fraction cells for gingival gum regeneration
GINTUIT
Embryonic/Adult Cultured Cells Related to Gingival Recession:
Bilayered cell therapy PMIDs: 22678374 18834238

Cochrane evidence based reviews: gingival recession

Genetic Tests for Gingival Recession

Anatomical Context for Gingival Recession

MalaCards organs/tissues related to Gingival Recession:

38
Bone, Testes, Tongue

Publications for Gingival Recession

Articles related to Gingival Recession:

(show top 50) (show all 487)
# Title Authors Year
1
Treatment of gingival recession in 2 surgical stages: free gingival graft plus coronally positioned flap. ( 29303764 )
2018
2
Sub-epithelial connective tissue graft for the management of Miller's class I and class II isolated gingival recession defect: A systematic review of the factors influencing the outcome. ( 29424485 )
2018
3
Quantitative measures of gingival recession and the influence of gender, race, and attrition. ( 29376198 )
2018
4
Effectiveness of laser adjunctive therapy for surgical treatment of gingival recession with flap graft techniques: a systematic review and meta-analysis. ( 29374364 )
2018
5
Xenogenic collagen matrix or autologous connective tissue graft as adjunct to coronally advanced flaps for coverage of multiple adjacent gingival recession: Randomized trial assessing non-inferiority in root coverage and superiority in oral health-related quality of life. ( 29087001 )
2018
6
Definitive abutments probably result in minimal decrease in bone loss and buccal gingival recession compared with traditional implants. ( 29150019 )
2018
7
Platelet-rich fibrin membrane does not improve clinical outcomes compared with otherA treatment modalities in the treatment of gingival recession. ( 28550846 )
2017
8
Connective Tissue Graft and Crown-Resin Composite Restoration for the Treatment of Gingival Recession Associated with Noncarious Cervical Lesions: Case Series. ( 28609509 )
2017
9
Histologic and Clinical Study of Gingival Recession Treated with Subepithelial Connective Tissue Graft: A Case Report. ( 27977823 )
2017
10
Gingival recession and root caries in the ageing population: a critical evaluation of treatments. ( 28266119 )
2017
11
Comparative Evaluation of Platelet Rich Fibrin and Dehydrated Amniotic Membrane for the Treatment of Gingival Recession- A Clinical Study. ( 28969268 )
2017
12
Tackle gingival recession head on. ( 28684804 )
2017
13
Tooth wear and gingival recession in 210 orthodontically treated patients: a retrospective cohort study. ( 29145570 )
2017
14
Use of buccal fat pads to prevent vestibular gingival recession of zygomatic implants. ( 29107123 )
2017
15
Long-term influence of fixed lingual retainers on the development of gingival recession: A retrospective, longitudinal cohort study. ( 28686089 )
2017
16
Staged Approach for Advanced Gingival Recession: Free Gingival Autograft Followed by Coronally Advanced Flap with PRF Membrane. ( 28658928 )
2017
17
A Novel Modification of Semilunar Coronally Advanced Flap for the Treatment of Gingival Recession: Case Series. ( 28196164 )
2017
18
Efficacy of Human Umbilical Stem Cells Cultured on Polylactic/ Polyglycolic Acid Membrane in the Treatment of Multiple Gingival Recession Defects: a Randomized Controlled Clinical Study. ( 28620633 )
2017
19
Lateral Access Pouch Technique to Treat Implants With Gingival Recession. ( 28862465 )
2017
20
Multiple Gingival Recession Coverage Treated with Vestibular Incision Subperiosteal Tunnel Access Approach with or without Platelet-Rich Fibrin - A Case Series. ( 29042736 )
2017
21
Patient-centered Microsurgical Management of Gingival Recession using Coronally Advanced Flap with Either Platelet-rich Fibrin or Connective Tissue Graft: A Comparative Analysis. ( 28839418 )
2017
22
Post-orthodontic position of lower incisors and gingival recession: A retrospective study. ( 29410758 )
2017
23
Gingival recession in mandibular incisors and symphysis morphology-a retrospective cohort study. ( 28637273 )
2017
24
Use of Allograft with Platelet Concentrate in the Treatment of Multiple Miller Class III Gingival Recession Defects: Report of Three Cases. ( 28402343 )
2017
25
Prevalence of gingival recession after orthodontic tooth movements. ( 28457262 )
2017
26
Clinical Comparison of the Subepithelial Connective Tissue versus Platelet-Rich Fibrin for the Multiple Gingival Recession Coverage on Anterior Teeth Using the Tunneling Technique. ( 28695021 )
2017
27
Two-Year Clinical Evaluation of Pedicled Buccal Fat Pad Alone and with Emdogain for Root Coverage of Severe Gingival Recession Defects: A Case Series. ( 29023624 )
2017
28
Xenogeneic Collagen Matrix Versus Connective Tissue Graft: Case Series of Various Gingival Recession Treatments. ( 27977826 )
2017
29
Coronally Advanced Flap Technique to Treat Class I and II Gingival Recession in Combination with Connective Tissue Graft or Equine Collagen Matrix: A Retrospective Study. ( 28609501 )
2017
30
Comparison of enamel matrix derivative (Emdogain) and subepithelial connective tissue graft for root coverage in patients with multiple gingival recession defects: A randomized controlled clinical study. ( 28396887 )
2017
31
A Comparison of Acellular Dermal Matrix Allograft and Periosteal Pedicle Graft Covered by Coronally Advanced Flap in the Treatment of Gingival Recession: 1-Year Follow-Up Study. ( 27333020 )
2016
32
Periosteal pedicle graft for the treatment of gingival recession defects current status and future prospects: What the evidence suggests? ( 27143840 )
2016
33
Patient-centered evaluation of microsurgical management of gingival recession using coronally advanced flap with platelet-rich fibrin or amnion membrane: A comparative analysis. ( 27011751 )
2016
34
A combined approach to non-carious cervical lesions associated with gingival recession. ( 27508164 )
2016
35
Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft. ( 26696115 )
2016
36
Gingival Unit Graft Versus Free Gingival Graft for Treatment of Gingival Recession: A Randomized Controlled Clinical Trial. ( 28392815 )
2016
37
Interdisciplinary Treatment of Gingival Recession. ( 27017259 )
2016
38
Effect of combination of ethylenediaminetetraacetic acid + tetracycline with coronally positioned flap in the treatment of gingival recession: A clinical study. ( 27041839 )
2016
39
Xenogeneic Collagen Matrix Versus Connective Tissue Graft: Case Series of Various Gingival Recession Treatments. ( 27560505 )
2016
40
Resin composite plus connective tissue graft to treat single maxillary gingival recession associated with non-carious cervical lesion: randomized clinical trial. ( 26847486 )
2016
41
Bristle splaying and its effect on pre-existing gingival recession-a 12-month randomized controlled trial. ( 27796575 )
2016
42
Esthetic dentistry for multiple gingival recession cases: Coronally advanced flap with bracket application. ( 27143837 )
2016
43
Multiple Gingival Recession Defects Treated with Coronally Advanced Flap and Either the VISTA Technique Enhanced with GEM 21S or Periosteal Pedicle Graft: A 9-Month Clinical Study. ( 26901301 )
2016
44
Management and prevention of gingival recession. ( 27045439 )
2016
45
Estimating Effects of Craniofacial Morphology on gingival recession and clinical attachment loss. ( 27930822 )
2016
46
Innovative Method of Conservative Aesthetic Treatment for Gingival Recession. ( 27135024 )
2016
47
Use of Double Layer of Acellular Dermal Matrix and Modified Tunnel Technique to Treat Multiple Adjacent Gingival Recession Defects. ( 27606567 )
2016
48
Clinical Comparison of Full and Partial Double Pedicle Flaps with Connective Tissue Grafts for Treatment of Gingival Recession. ( 27602394 )
2016
49
Gingival recession and oral health-related quality of life: a population-based cross-sectional study in Brazil. ( 26957046 )
2016
50
Pedicled buccal fat pad graft for root coverage in severe gingival recession defect. ( 27143839 )
2016

Variations for Gingival Recession

Expression for Gingival Recession

Search GEO for disease gene expression data for Gingival Recession.

Pathways for Gingival Recession

Pathways related to Gingival Recession according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 C1R C1S
2 11.04 C1R C1S
3 10.94 C1R C1S SERPINF2
4 10.7 C1R C1S

GO Terms for Gingival Recession

Cellular components related to Gingival Recession according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 C1R C1S SERPINF2

Biological processes related to Gingival Recession according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of complement activation GO:0030449 8.96 C1R C1S
2 complement activation GO:0006956 8.62 C1R C1S

Molecular functions related to Gingival Recession according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.92 BCL2A1 IMPA1 LRRFIP1 SERPINF2

Sources for Gingival Recession

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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