MCID: GNG013
MIFTS: 60

Gingivitis malady

Gastrointestinal diseases category

Summaries for Gingivitis

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Wikipedia:65 Gingivitis (\"inflammation of the gum tissue\") is a non-destructive periodontal disease. The most... more...

MalaCards based summary: Gingivitis, also known as chronic gingivitis, is related to periodontitis and periodontal disease. An important gene associated with Gingivitis is GUSB (glucuronidase, beta), and among its related pathways are Selected targets of C EBPalpha and RNA Polymerase I Promoter Opening. The drug carbamide peroxide and the compounds 4-nitroanilide and elastatinal have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Gingivitis

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 40NCIt, 29ICD9CM, 27ICD10
See all sources

Gingivitis, Aliases & Descriptions:

Name: Gingivitis 10 12 45 62
Chronic Gingivitis 10 45 62
 
Acute Gingivitis 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Related Diseases for Gingivitis

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Diseases related to Gingivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 420)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.8IL1A, MMP8
2periodontal disease31.1GUSB, ELANE
3aggressive periodontitis30.9IL1A, MMP8
4leukemia30.5GUSB, SERPINB2, IL1A, CTSG
5arthritis30.5IL1A, CTSG
6rheumatoid arthritis30.2GUSB, SERPINB2, MMP13, MMP8, ELANE, IL1A
7chediak-higashi syndrome30.1CTSG, GUSB
8keloids29.9MMP13, MMP8
9pneumonia29.9CTSG, ELANE, MMP8
10wegener granulomatosis29.7CTSG, ELANE
11colorectal cancer29.7MMP13, SERPINB2, GUSB
12inflammatory bowel disease29.7GUSB, MMP13, ELANE, CTSG
13tongue squamous cell carcinoma29.6SERPINB2, MMP13, CST3, CTSG
14lung cancer29.6CST3, MMP8, MMP13, SERPINB2, GUSB
15atherosclerosis29.5SERPINB2, MMP13, MMP8, ELANE, IL1A, CST3
16gingival overgrowth11.1
17gingival recession11.1
18necrotizing ulcerative gingivitis10.9
19fibromatosis10.8
20gingival disease10.6
21gingival hypertrophy10.5
22hypertrichosis terminalis, generalized, with or without gingival hyperplasia10.5
23hypertrichosis10.5
24fibromatosis, gingival10.5
25blindness10.4
26endotheliitis10.4
27lichen planus10.4
28granular cell tumor10.4
29epulis10.4
30jones syndrome10.3
31oral lichen planus10.3
32cervicitis10.3
33zimmermann-laband syndrome10.3
34vulvovaginal gingival syndrome10.3
35amelogenesis imperfecta10.3
36cicatricial pemphigoid10.3
37mental retardation10.3
38vulvovaginitis10.3
39congenital epulis10.2
40ramon syndrome10.2
41fibromatosis, gingival, 310.2
42fibromatosis, gingival, 210.2
43fibromatosis, gingival, 410.2
44periostitis10.2
45stomatitis10.2
46juvenile hyaline fibromatosis10.2
47keratosis focal palmoplantar gingival10.2
48kindler syndrome10.2
49pemphigus vulgaris10.2
50fibroma10.2

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to gingivitis

Symptoms for Gingivitis

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Drugs & Therapeutics for Gingivitis

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Drug clinical trials:

Search ClinicalTrials for Gingivitis

Search NIH Clinical Center for Gingivitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Gingivitis

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Anatomical Context for Gingivitis

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MalaCards organs/tissues related to Gingivitis:

33
Bone, Neutrophil, Monocytes, Endothelial, Heart, T cells, Testes, Tongue, Kidney, Salivary gland, Myeloid, Liver, Lung, Skin, Smooth muscle, Colon, B cells, Bone marrow, Whole blood, Brain, Thyroid, Breast, Ovary, Prostate, Testis

Animal Models for Gingivitis or affiliated genes

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MGI Mouse Phenotypes related to Gingivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1CTSG, IL1A, ELANE, MMP8, SERPINB2
2MP:00053977.9GUSB, SERPINB2, ELANE, IL1A, CTSG
3MP:00020067.7CTSG, CST3, IL1A, ELANE, MMP8
4MP:00053767.1GUSB, SERPINB2, MMP13, ELANE, IL1A, CST3

Publications for Gingivitis

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Articles related to Gingivitis:

(show top 50)    (show all 2794)
idTitleAuthorsYear
1
The Effectiveness of Propolis on Gingivitis: A Randomized Controlled Trial. (25380344)
2014
2
Immediate implant placement, reconstruction of compromised sockets, and repair of gingival recession with a triple graft from the maxillary tuberosity: a variation of the immediate dentoalveolar restoration technique. (24939252)
2014
3
Shallow localized gingival recession defects treated with modified coronally repositioned flap technique: A case series. (24926219)
2013
4
Acute myelomonocytic leukemia presenting with gingival enlargement as the only clinical manifestation. (23493961)
2012
5
Loss of basement membrane integrity in human gingival overgrowth. (21483030)
2011
6
Gingival overgrowth and drug association: a review. (23196317)
2011
7
Smad7 blocks transforming growth factor-I^1-induced gingival fibroblast-myofibroblast transition via inhibitory regulation of Smad2 and connective tissue growth factor. (21054221)
2011
8
A two-stage approach using an autogenous masticatory mucosal graft and an autogenous connective tissue graft to treat gingival recession: a case report. (20465031)
2010
9
Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans. (20096665)
2010
10
Gingival disease and secretory immunoglobulin a in non-stimulated saliva in children. (21462892)
2010
11
Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases]. (19594076)
2009
12
Prostaglandin E2 inhibits the proliferation of human gingival fibroblasts via the EP2 receptor and Epac. (19582788)
2009
13
Immortalization of normal human gingival keratinocytes and cytological and cytogenetic characterization of the cells. (19184294)
2009
14
Effect of transforming growth factor-beta1 on expression of the connective tissue growth factor (CCN2/CTGF) gene in normal human gingival fibroblasts and periodontal ligament cells. (19210343)
2009
15
Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo. (19186973)
2009
16
Clinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosis. (18061489)
2008
17
Gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy. (18269661)
2008
18
Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis. (18727658)
2008
19
Increased interleukin-18 in gingival crevicular fluid from periodontitis patients. (18279187)
2008
20
Subepithelial connective tissue graft in the treatment of multiple gingival recession. (17618142)
2007
21
Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate. (17199549)
2007
22
Pure choriocarcinoma of testis with rare gingival and skin metastases. (17342276)
2007
23
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (16670920)
2006
24
Molecular changes in the gingival epithelium associated with necrotizing ulcerative periodontitis: a case report. (16642908)
2006
25
Profiling the cytokines in gingival crevicular fluid using a cytokine antibody array. (16671879)
2006
26
Clinical effect of a triclosan containing dentifrice on gingivitis during pregnancy and post-partum. (17121312)
2006
27
Apoptosis in cyclosporin A-induced gingival overgrowth: a histological study. (15974838)
2005
28
Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts. (15324353)
2004
29
Effects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cells]. (15196384)
2004
30
The immunosuppressant and hyperplasia-inducing drug cyclosporin A regulates the cell cycle and cyclin B1 gene expression in gingival fibroblasts in vitro. (15221438)
2004
31
Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. (15732868)
2004
32
The epidemiology, etiology, and pathophysiology of acute necrotizing ulcerative gingivitis associated with malnutrition. (15318254)
2004
33
An experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice. (16296255)
2004
34
Interleukin-1beta, clinical parameters and matched cellular-histopathologic changes of biopsied gingival tissue from periodontitis patients. (12753361)
2003
35
Expression of endothelin-1 in gingival epithelial cells. (12828660)
2003
36
Reduced gingival fluid flow: a peripheral marker of the pharmacological effect of roquinimex. (15035809)
2003
37
Localized gingival recession caused by a C-PAP mask: a case report. (12451912)
2002
38
IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. (12237122)
2002
39
Comparative 6-month clinical study of a subepithelial connective tissue graft and acellular dermal matrix graft for the treatment of gingival recession. (11759858)
2001
40
Human gingival crevicular fluid contains MRP8 (S100A8) and MRP14 (S100A9), two calcium-binding proteins of the S100 family. (10728975)
2000
41
Analysis of gingival crevicular fluid intracytoplasmic enzyme activity in patients with adult periodontitis and rapidly progressive periodontitis. A longitudinal study model with periodontal treatment. (9802716)
1998
42
Evaluation of osteocalcin and pyridinium crosslinks of bone collagen as markers of bone turnover in gingival crevicular fluid during different stages of orthodontic treatment. (9667483)
1998
43
Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases. (9010272)
1997
44
Human papillomavirus in a patient with severe gingival overgrowth associated with cyclosporine therapy. A case report. (8724712)
1996
45
Bacterial proteases in gingival crevicular fluid before and after periodontal treatment. (7893545)
1995
46
Altered collagen metabolism in nifedipine-induced gingival overgrowth. (7877076)
1994
47
Gingival fluid IL-1 beta and IL-6 levels in menopause. (8126239)
1994
48
Hypertrichosis universalis congenita: a separate entity, or the same disease as gingival fibromatosis? (8415305)
1993
49
Interleukin-1 beta in the gingival tissues of patients with periodontitis: immunohistochemical data]. (8510615)
1993
50
Spirochetes in early lesions of necrotizing ulcerative gingivitis experimentally induced in beagles. (2087354)
1990

Variations for Gingivitis

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Expression for genes affiliated with Gingivitis

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Search GEO for disease gene expression data for Gingivitis.

Pathways for genes affiliated with Gingivitis

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Compounds for genes affiliated with Gingivitis

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Compounds related to Gingivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
14-nitroanilide4510.0CTSG, ELANE
2elastatinal4510.0ELANE, CTSG
3saccharin45 310.9ELANE, CTSG
4barbiturate459.9MMP13, MMP8
5scca1459.8CTSG, SERPINB2
6ulinastatin459.6ELANE, GUSB
7cytochalasin b459.6ELANE, GUSB, CTSG
8hocl459.6MMP8, ELANE, CTSG
9tenidap45 3010.5IL1A, ELANE
10hydroxamate459.5MMP13, SERPINB2, MMP8
11thermolysin459.5MMP13, CTSG, ELANE
12benzphetamine45 1310.4IL1A, GUSB
13batimastat45 61 1311.4MMP13, ELANE, MMP8
14doxycycline45 1310.4MMP8, ELANE, MMP13
15vancomycin45 1310.3ELANE, CST3
16sodium dodecylsulfate459.3CTSG, ELANE, IL1A
17kininogen459.1CTSG, CST3, ELANE
18(4-aminophenyl)mercuric acetate459.1CTSG, ELANE, MMP8, MMP13
19urea45 26 1311.1CTSG, CST3, MMP8
20n-formylmethionyl-leucylphenylalanine459.1GUSB, ELANE, IL1A, CTSG
21leukotriene b445 61 2611.0IL1A, GUSB, ELANE, CTSG
22fmlp459.0GUSB, CTSG, IL1A, ELANE
23egcg459.0ELANE, MMP13, IL1A
24tetracycline45 1310.0MMP8, MMP13, GUSB, IL1A
25glycosaminoglycan459.0MMP8, IL1A, MMP13, GUSB
26p002459.0MMP13, MMP8, CST3
27endotoxin458.9IL1A, ELANE, CTSG, SERPINB2
28genistein45 30 61 3 26 1313.9MMP8, MMP13, IL1A, GUSB
29captopril45 61 51 30 1312.9IL1A, CST3, ELANE
30hyaluronic acid45 269.9MMP13, ELANE, IL1A
31cycloheximide458.7CTSG, IL1A, SERPINB2, MMP13
32hydrogen45 269.7CTSG, CST3, SERPINB2, MMP8
33prostacyclin458.7CTSG, IL1A, ELANE
34creatinine458.6GUSB, IL1A, CST3, CTSG
35aspartate458.6CTSG, CST3, IL1A, GUSB
36h2o2458.5IL1A, SERPINB2, CTSG, ELANE, MMP8
37nitric oxide45 26 1310.5MMP13, MMP8, SERPINB2, IL1A, CTSG
38lactate458.4CTSG, GUSB, CST3, MMP8, ELANE
39cysteine458.2ELANE, MMP8, MMP13, CST3, CTSG
40heparin45 30 26 1311.1SERPINB2, MMP13, ELANE, GUSB, IL1A, CTSG
41cyclosporin a45 30 6110.1CST3, IL1A, MMP8, ELANE, SERPINB2
42dexamethasone45 51 30 1311.1SERPINB2, MMP13, CST3, IL1A
43pge2458.0SERPINB2, GUSB, MMP13, IL1A, MMP8, ELANE
44vegf458.0MMP13, SERPINB2, IL1A, CST3, MMP8
45retinoic acid45 269.0IL1A, ELANE, SERPINB2, MMP13, MMP8, CTSG
46superoxide45 269.0CTSG, GUSB, CST3, ELANE, MMP8, SERPINB2
47calcium45 51 26 1310.8CTSG, MMP8, MMP13, SERPINB2, GUSB, CST3
48fibrinogen457.8ELANE, CST3, MMP8, MMP13, SERPINB2, CTSG
49aprotinin45 138.6CST3, CTSG, IL1A, SERPINB2, MMP13, ELANE
50serine457.2CST3, ELANE, MMP8, MMP13, SERPINB2, IL1A

GO Terms for genes affiliated with Gingivitis

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Cellular components related to Gingivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.3CTSG, ELANE
2extracellular vesicular exosomeGO:00700628.4CTSG, CST3, ELANE, GUSB
3extracellular spaceGO:00056157.2SERPINB2, MMP13, MMP8, IL1A, CST3, CTSG
4extracellular regionGO:00055766.7CTSG, SERPINB2, MMP13, MMP8, ELANE, IL1A

Biological processes related to Gingivitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immune responseGO:00507789.5ELANE, CTSG
2negative regulation of growth of symbiont in hostGO:00441309.3CTSG, ELANE
3negative regulation of endopeptidase activityGO:00109519.2CST3, SERPINB2
4collagen catabolic processGO:00305749.0ELANE, MMP8, MMP13
5extracellular matrix disassemblyGO:00226178.8CTSG, ELANE, MMP8, MMP13
6proteolysisGO:00065088.8MMP13, MMP8, ELANE, CTSG
7extracellular matrix organizationGO:00301988.7MMP13, MMP8, ELANE, CTSG

Molecular functions related to Gingivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:00082339.6CTSG, ELANE
2serine-type endopeptidase activityGO:00042529.1CTSG, ELANE, MMP8
3protease bindingGO:00020208.8CST3, ELANE

Products for genes affiliated with Gingivitis

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Sources for Gingivitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet