Gingivitis malady

Wikipedia: Gingivitis (\"inflammation of the gum tissue\") is a non-destructive periodontal disease. The most...⁴⁴ more...

MalaCards: Gingivitis, also known as chronic gingivitis, is related to carcinoma and gingival overgrowth. An important gene associated with Gingivitis is SOS1 (son of sevenless homolog 1 (Drosophila)), and among its related pathways are Transendothelial Migration of Leukocytes and PAK Pathway. The drug carbamide peroxide and the compounds vegf and estrogen have been mentioned in the context of this disorder. Affiliated tissues include whole blood, small intestine and colon, and related mouse phenotypes are mortality/aging and immune system.

Aliases & Descriptions:

gingivitis 6 8 32 43 chronic gingivitis 6 32 43 acute gingivitis 6 43 chronic gingivitis nos (disorder) 6

chronic gingivitis (disorder) 6 acute gingivitis (disorder) 6 gingivitis (disorder) 6 gingivitis nos 6

Diseases related to gingivitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 896)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	48.7	PIK3CG, CNR1, CNR2, PCNA, BTK, SELE
2	gingival overgrowth	47.2	PIGO, PCNA, BSG, MS4A1, CD36, ITGA2
3	periodontitis	43.9	BSG, LBP, MPO, CD209, CD36, CD14
4	periodontal disease	43.7	SERPINB2, BSG, BGLAP, LAMC2, S100A8, S100A9
5	rheumatoid arthritis	41.2	PIK3CG, CNR1, CNR2, PCNA, BTK, SELE
6	fibromatosis	36.3	PCNA, SERPINH1, SERPINE1, VIM, BSG, MYC
7	aggressive periodontitis	35.0	SELE, SERPINE1, VEGFA, VCAM1, S100A8, MPO
8	squamous cell carcinoma	34.8	PCNA, SELL, SETD2, SERPINH1, SERPINF1, SERPINB2
9	atherosclerosis	34.5	PIK3CG, CNR1, CNR2, PCNA, SELE, SELL
10	pneumonia	33.8	BTK, SELE, SELL, SETD2, SERPINF2, SERPINH1
11	diabetes mellitus	33.4	PIK3CG, CNR1, CNR2, SELE, SELL, SERPINF2
12	arthritis	33.2	SELL, VIP, MMP3, IL17A, IL1A, IL1B
13	periostitis	32.1	VEGFA, BMP2, BGLAP, KDR, MUC1, CD36
14	cervicitis	31.5	PIK3CG, CNR1, PCNA, SELE, SETD2, SERPINH1
15	immunodeficiency	31.5	BTK, SELL, VIP, MYD88, BMP6, PARP1
16	esophagitis	31.4	PIK3CG, CNR1, PCNA, SELE, SELL, SETD2
17	fibromatosis, gingival	31.3	SERPINH1, CD36, MMP1, MMP2, GINGF2, GINGF3
18	hepatocellular carcinoma	31.0	PIK3CG, CNR1, CNR2, PCNA, SELE, SETD2
19	down syndrome	30.5	CNR1, CNR2, SERPINE1, SERPINA3, VIP, VEGFA
20	ovarian carcinoma	30.5	PIK3CG, PCNA, SELL, SETD2, SERPINB2, SERPINE1
21	sarcoma	29.8	PIK3CG, PCNA, SELE, SETD2, SERPINH1, SERPINB2
22	osteosarcoma	29.4	PIK3CG, CNR1, PCNA, SETD2, SERPINF1, SERPINE1
23	hypoxia	29.0	PIK3CG, PCNA, SELE, SELL, SETD2, SERPINF1
24	pemphigus vulgaris	28.9	VCL, CD79A, CDH3, CDH1, IVL, MMP9
25	lichen planus	28.8	PCNA, VEGFA, VCAM1, BCL2, SDC1, LAMC2
26	vulvovaginitis	28.8	CD79A, IL10, IL13, IL4, HSPD1, HLA-DQB1
27	cholesterol	28.5	PIK3CG, CNR1, CNR2, SELE, SELL, SERPINF2
28	type 2 diabetes mellitus	27.8	CNR1, SELE, SELL, SERPINF2, SERPINE1, VCAM1
29	thalassemia	27.7	SELE, VCAM1, BGLAP, B2M, CD151, ITGB1
30	pemphigus	27.4	VCL, MS4A1, JUN, CD79A, CD40LG, CDH3
31	beta thalassemia	27.4	BGLAP, B2M, CD151, ITGB1, INS, GSN
32	osteoporosis	27.3	CNR1, CNR2, SELE, VEGFA, BMP2, BMP6
33	merkel cell carcinoma	26.4	PCNA, VIM, KDR, BCL2, MUC1, CEACAM3
34	gonococcal synovitis	23.7	PIK3CG, CNR1, CNR2, BTK, SELE, SELL
35	prostatitis	21.1	PIK3CG, CNR1, CNR2, PCNA, SELE, SETD2
36	leukemia	20.2	PIK3CG, CNR1, CNR2, PCNA, BTK, SELE
37	fibrosis	19.0	PIK3CG, CNR1, CNR2, PCNA, SELE, SELL
38	melanoma	18.4	PIK3CG, PCNA, SELE, SETD2, SERPINF1, SERPINB2
39	adenocarcinoma	18.3	PIK3CG, CNR1, PCNA, SELE, SELL, SETD2
40	pancreatitis	17.9	PIK3CG, CNR1, CNR2, PCNA, SELE, SETD2
41	osteoarthritis	17.4	PIK3CG, CNR1, CNR2, SERPINB2, SERPINE1, SERPINA3
42	colorectal cancer	17.2	PIGO, PIK3CG, CNR1, CNR2, PCNA, SELE
43	factor v leiden thrombophilia	17.1	SELL, SETD2, SERPINF2, SERPINE1, SERPINA3, BMP2
44	dermatitis	17.0	CNR1, BTK, SELE, SELL, VIM, VIP
45	cystic fibrosis	17.0	PIK3CG, PCNA, SELL, SERPINA3, VIP, VEGFA
46	keratoconus	16.9	SERPINF1, VIM, BSG, BMP2, S100A1, ITGA6
47	viral infectious disease	16.7	PIK3CG, BTK, BSG, MYD88, LIF, PARP1
48	gastric cancer	16.7	PIK3CG, PCNA, SELE, SELL, SETD2, SERPINF2
49	inflammatory bowel disease	16.7	SELE, SELL, SERPINA3, VIP, VCAM1, BGLAP
50	aortic aneurysm	16.7	SELE, SELL, SERPINF2, SERPINE1, VEGFA, MYLK

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carbamide peroxide

MalaCards organs/tissues related to gingivitis:

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MGI Mouse Phenotypes related to gingivitis:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	16.7	CNR1, BTK, SELE, SETD2, SERPINH1, SERPINB2
2	immune system phenotype	MP:0005387	15.8	CNR2, BTK, SELL, SERPINB2, VIM, BSG
3	hematopoietic system phenotype	MP:0005397	14.6	PCNA, BTK, SERPINB2, MYD88, BMPR1A, CLNK
4	homeostasis/metabolism phenotype	MP:0005376	12.8	PIK3CG, CNR1, BTK, SELE, SELL, SETD2
5	nervous system phenotype	MP:0003631	12.5	CNR1, SERPINH1, SERPINF1, VDAC1, VCL, VCP
6	behavior/neurological phenotype	MP:0005386	12.4	CNR1, SELE, SERPINI1, VIM, VIP, VDAC1
7	cellular phenotype	MP:0005384	12.1	PIK3CG, CNR1, PCNA, BTK, SELE, SELL
8	respiratory system phenotype	MP:0005388	11.6	SELL, BMPR1A, LIF, S1PR3, CD14, ITGB3
9	limbs/digits/tail phenotype	MP:0005371	11.6	BTK, VEGFA, VCL, BMP2, BMPR1A, RAC1
10	endocrine/exocrine gland phenotype	MP:0005379	11.5	SELL, BMPR1A, BDKRB2, BCL2L2, LDHC, CDC42
11	craniofacial phenotype	MP:0005382	11.5	BMPR1A, LAMA5, GUSB, INPP5E, IL12B, IL17A
12	cardiovascular system phenotype	MP:0005385	11.4	PIK3CG, SELE, SELL, SETD2, SERPINF1, SERPINE1
13	growth/size phenotype	MP:0005378	11.4	PIK3CG, CNR1, BTK, SELE, SETD2, SERPINB2
14	integument phenotype	MP:0010771	11.3	PIK3CG, CNR1, CNR2, BTK, MYC, RAC1
15	reproductive system phenotype	MP:0005389	11.2	SERPINF1, VIP, VEGFA, BMP2, BMPR1A, LIF
16	renal/urinary system phenotype	MP:0005367	11.2	MYD88, MYLK, BDKRB2, BCAM, BCL2, CHUK
17	tumorigenesis	MP:0002006	11.1	BTK, SELL, SERPINE1, MYC, MYD88, BMPR1A
18	normal phenotype	MP:0002873	11.0	SELE, VIP, VEGFA, MYC, MYLK, BMP2
19	embryogenesis phenotype	MP:0005380	10.7	SETD2, VIM, VCL, MYC, RAC1, PARP1
20	other phenotype	MP:0005395	10.7	CNR1, SERPINH1, KDR, LAMA5, LAMC2, CDKN2A
21	digestive/alimentary phenotype	MP:0005381	10.5	BTK, SERPINF1, VEGFA, VCL, MYC, MYLK
22	liver/biliary system phenotype	MP:0005370	10.5	VEGFA, LIF, LBP, SAT1, CD36, CD19
23	hearing/vestibular/ear phenotype	MP:0005377	10.5	MYC, MYD88, BMP2, BMPR1A, PARP1, BCL2
24	skeleton phenotype	MP:0005390	10.3	PIK3CG, CNR1, VEGFA, VCP, MYC, MYD88
25	vision/eye phenotype	MP:0005391	10.3	SELE, SERPINF1, VIM, VEGFA, MYD88, BMPR1A
26	no phenotypic analysis	MP:0003012	9.9	CNR1, PCNA, VEGFA, VCAM1, MYC, MYD88
27	muscle phenotype	MP:0005369	9.6	PIK3CG, SERPINB2, VIM, VEGFA, VCL, VCP
28	adipose tissue phenotype	MP:0005375	9.0	CNR1, SERPINE1, MYC, MYD88, LIF, BDKRB2

Articles related to gingivitis:

(show top 50)    (show all 844)

id	Title	Authors	Year	Affiliating Genes
1	Changes in gingival crevicular fluid inflammatory med iator levels during the induction and resolution of experimental gingivitis in humans. (20447255)	Offenbacher S.... Aspiras M.	2010	IL1B
2	Gingival crevicular fluid levels of oncostatin M in p eriodontal conditions. (20189410)	Thorat Manojkumar S.... Raju A.	2010	OSM
3	Application of label-free absolute quantitative prote omics in human gingival crevicular fluid by LC/MS E (gingival exudatome). (20205380)	Bostanci N.... Donos N.	2010	LCP1
4	Interleukin-1 beta levels in gingival crevicular flui d and serum under naturally occurring and experimentally induced gingivitis. (20528961)	Trombelli L.... Farina R.	2010	IL1B
5	Correlations between the gingival crevicular fluid MM P8 levels and gingival overgrowth in patients with fixed orthodontic devices. (20809029)	Surlin P.... Pirici D.	2010	MMP8
6	Prostaglandin E2 inhibits the proliferation of human gingival fibroblasts via the EP2 receptor and Epac. (19582788)	Weinberg E.... Weinreb M.	2009	PTGER2, RAPGEF3, ADCY10
7	Relationship between gingival angiopoietin-1 concentr ations and depth of the adjacent gingival sulcus. (19722795)	Lester S.R.... Johnson R.B.	2009	TNF, IL1B, ANGPT1
8	Expression profile of human gingival fibroblasts induced by interleukin-1beta reveals central role of nuclear factor-kappa B in stabilizing human gingival fibroblasts during inflammation. (19405838)	Vardar-Sengul S.... Mercola D.	2009	PARP1, NFKBIE
9	Differential gene and protein expression of tissue in hibitors of metalloproteinases (TIMP)-3 and TIMP-4 in gingival tissues from dru g induced gingival overgrowth. (19450793)	Nakasone N.... Yoshie H.	2009	TIMP3, TIMP4
10	Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans. (19961380)	Offenbacher S.... Ho B.	2009	IL1B, IL8, IL1A
11	Lactoferrin in Gingival Crevicular Fluid and Peripheral Blood during Experimental Gingivitis. (19262727)	Ozdemir B.... Us D.	2009	LTF
12	Drop in transforming growth factor-alpha and osteopro tegerin level in gingival crevicular fluid from patients with gingivitis. (19591043)	Otogoto J.... Mogi M.	2009	TNFRSF11B
13	Tumor necrosis factor-alpha stimulates gingival epithelial cells to release high mobility-group box 1. (18067550)	Morimoto Y.... Maruyama I.	2008	TNF
14	Gingival crevicular fluid transforming growth factor-beta1 in cyclosporine and tacrolimus treated renal transplant patients without gingival overgrowth. (18342291)	GA1rkan A.... Atilla G.	2008	TGFB1
15	Do MMP-1 levels of gingival fibroblasts have a role in the gingival overgrowth of cyclosporine-treated patients? (18261580)	Sonmez S.... Camsari T.	2008	MMP1
16	Levels of metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-1 in gingival crevicular fluid of patients with periodontitis, gingivitis, and healthy gingiva. (17334003)	Maeso G.... Bascones A.	2007	MMP1, TIMP1
17	A combination of alleles 2 of interleukin (IL)-1A(-889) and IL-1B(+3954) is associated with lower gingival bleeding tendency in plaque-induced gingivitis in young adults of Arabic heritage. (17492470)	Muller H.P.... Barrieshi-Nusair K.M.	2007	IL1B, IL1A
18	Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines. (17956473)	Sukkar T.Z.... Seymour R.A.	2007	MMP1
19	Levels of matrix metalloproteinases-8 and -9 with simultaneous presence of periodontal pathogens in gingival crevicular fluid as well as matrix metalloproteinase-9 and cholesterol in blood. (16953818)	Soder B.... Meurman J.	2006	MMP8, MMP9
20	Cell interactions between human gingival fibroblasts and monocytes stimulate the production of matrix metalloproteinase-1 in gingival fibroblasts. (16499713)	Domeij H.... Modeer T.	2006	MMP1
21	Analysis of proliferative activity in oral gingival e pithelium in immunosuppressive medication induced gingival overgrowth. (16712728)	Bulut S.... Bulut O.E.	2006	PCNA
22	Interleukin-1beta, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. (16842511)	Orozco A.... Seymour G.J.	2006	IL1B, IL18
23	Matrix metalloproteinase-1 and -8 in gingival crevicular fluid during orthodontic tooth movement: a pilot study during 1 month of follow-up after fixed appliance activation. (15817630)	Ingman T.... Sorsa T.	2005	MMP8
24	Expression of human beta-defensin-3 in gingival epithelia. (16302926)	Lu Q.... Jin L.	2005	DEFB103B
25	Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis. (15811056)	Vernal R.... Gamonal J.	2005	IL17A
26	Human gingival mucosal keratinocytes exhibiting anchorage-independent growth express increased inducible nitric oxide synthase: regulation by MAP kinases. (15566970)	Chunglok W.... Chamulitrat W.	2004	NOS2
27	Proliferative response to phenytoin and nifedipine in gingival fibroblasts cultured from humans with gingival fibromatosis. (15312153)	Sano M.... Murakami H.	2004	EDN1
28	Effect of cyclosporin A on human gingival fibroblast collagen turnover in relation to the development of gingival overgrowth: an in vitro study. (15183848)	Gagliano N.... Gioia M.	2004	MMP1
29	Levels of TGFbeta1 in gingival crevicular fluid during a 21-day experimental model of gingivitis. (12657035)	Wright H.J.... Matthews J.B.	2003	TGFB1, SLPI
30	Effect of smoking on gingival crevicular fluid cytokine profile during experimental gingivitis. (14761123)	Giannopoulou C.... Mombelli A.	2003	IL1B
31	Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue. (11940142)	Kiili M.... Chen H.W.	2002	MMP8, MMP13
32	Hepatocyte growth factor in gingival crevicular fluid and the distribution of hepatocyte growth factor-activator in gingival tissue from adult periodontitis. (12243969)	Kakimoto K.... Daikuhara Y.	2002	HGF, HGFAC
33	Concentration of interleukin-1beta and neutrophil elastase activity in gingival crevicular fluid during experimental gingivitis. (11350521)	GonzA!les J.R.... Meyle J.	2001	ELANE
34	Detection of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2(PAI-2) in gingival crevicular fluid from healthy, gingivitis and periodontitis patients. (10743860)	Yin X.... Bartold P.M.	2000	PLAT, SERPINB2
35	Relationship of surface epithelium concentrations of IL-1 alpha and IL-1 beta to clinical inflammation during experimental gingivitis. (10949833)	Biesbrock A.... Yeh C.H.	2000	IL1B, IL1A
36	Analysis of human gingival tissue and gingival crevicular fluid beta-glucuronidase activity in specific periodontal diseases. (10807127)	Layik M.... Eratalay K.	2000	GUSB
37	The association of calprotectin level in gingival crevicular fluid with gingival index and the activities of collagenase and aspartate aminotransferase in adult periodontitis patients. (10776922)	Nakamura T.... Nagata T.	2000	SLC17A5
38	Effect of cysteine protease of Porphyromonas gingival is on adhesion molecules in gingival epithelial cells. (10446759)	Wang P.L.... Ohura K.	1999	VCAM1
39	Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. (9712771)	Krisanaprakornkit S.... Dale B.A.	1998	DEFB1
40	IgG and IgA subclass mRNA-bearing plasma cells in periodontitis gingival tissue and immunoglobulin levels in the gingival crevicular fluid. (9010271)	Takahashi K.... Kinane D.F.	1997	CD79A
41	PDGF-B producing cells and PDGF-B gene expression in normal gingival and cyclosporine A-induced gingival overgrowth. (8708959)	Plemons J.M.... Iacopino A.M.	1996	PDGFB
42	Chemiluminescent assay of alkaline phosphatase in human gingival crevicular fluid: investigations with an experimental gingivitis model and studies on the source of the enzyme within crevicular fluid. (8811480)	Chapple I.L.... Matthews J.B.	1996	SLPI
43	Aggravation of gingival inflammatory symptoms during pregnancy associated with the concentration of plasminogen activator inhibitor type 2 (PAI-2) in gingival fluid. (8814598)	Kinnby B.... Astedt B.	1996	PLAU, PLAT, SERPINE1
44	Gingival metastasis of large-cell lung cancer that produced G-CSF (8583722)	Miyatake K.... Moritani Y.	1995	CSF3
45	Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects. (7722846)	Kunimatsu K.... Yamamoto K.	1995	CTSG
46	Site-specific alkaline phosphatase levels in gingival crevicular fluid in health and gingivitis: cross-sectional studies. (8089243)	Chapple I.L.... Lumley P.J.	1994	ALPP
47	Acute-phase proteins in gingival crevicular fluid during experimentally induced gingivitis. (7515961)	Adonogianaki E.... Kinane D.F.	1994	A2M
48	Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis. (1610303)	Beighton D.... Naylor M.N.	1992	HEXA
49	Neutrophil elastase and its inhibitors in human gingival crevicular fluid during experimental gingivitis. (1372921)	Giannopoulou C.... Cimasoni G.	1992	ELANE
50	Granulocyte medullasin levels in gingival crevicular fluid from chronic adult periodontitis patients and experimental gingivitis subjects. (2148948)	Kunimatsu K.... Yamamoto K.	1990	ELANE

Genes related to gingivitis according to GeneCards:

(show top 50)    (show all 438)

id	Symbol	Description	Score	GeneCards Section Context
1	SOS1	son of sevenless homolog 1 (Drosophila)	11.1	Publications, Aliases & Descriptions, Summaries, Expressions
2	FAM20A	family with sequence similarity 20, member A	11.0	Publications, Summaries
3	HTGH	Hypertrichosis terminalis, generalized, with or without gingival hyperplasia	11.0	Aliases & Descriptions
4	GINGF3	Fibromatosis, gingival, 3	11.0	Aliases & Descriptions
5	GINGF4	gingival fibromatosis, hereditary, 4	11.0	Publications, Aliases & Descriptions
6	GINGF2	gingival fibromatosis, hereditary, 2	11.0	Aliases & Descriptions, Publications
7	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
8	DSPP	dentin sialophosphoprotein	11.0	Publications
9	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
10	IL1A	interleukin 1, alpha	11.0	Publications
11	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
12	TGFB1	transforming growth factor, beta 1	11.0	Publications
13	IL1B	interleukin 1, beta	11.0	Publications
14	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
15	CTSB	cathepsin B	11.0	Publications
16	FGF7	fibroblast growth factor 7	11.0	Publications
17	ELANE	elastase, neutrophil expressed	11.0	Publications
18	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
19	LPO	lactoperoxidase	11.0	Publications
20	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.0	Publications
21	GUSB	glucuronidase, beta	11.0	Publications
22	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
23	DCN	decorin	11.0	Publications
24	CTSL1	cathepsin L1	11.0	Publications
25	ANTXR2	anthrax toxin receptor 2	11.0
26	CTGF	connective tissue growth factor	11.0	Publications
27	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0	Publications
28	LOX	lysyl oxidase	11.0	Publications
29	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	11.0	Publications
30	COL1A1	collagen, type I, alpha 1	11.0	Publications
31	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	11.0	Publications
32	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
33	TIMP4	TIMP metallopeptidase inhibitor 4	11.0	Publications
34	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	11.0	Publications
35	PIGO	phosphatidylinositol glycan anchor biosynthesis, class O	11.0
36	DEFB1	defensin, beta 1	11.0	Publications
37	HAS3	hyaluronan synthase 3	11.0	Publications
38	HYAL1	hyaluronoglucosaminidase 1	11.0	Publications
39	GIN1	gypsy retrotransposon integrase 1	11.0
40	CTSG	cathepsin G	10.9	Publications
41	TBPL1	TBP-like 1	10.9
42	MMP13	matrix metallopeptidase 13 (collagenase 3)	10.9	Publications
43	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	10.9	Publications
44	MMP10	matrix metallopeptidase 10 (stromelysin 2)	10.9	Publications
45	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	10.9	Publications
46	TIMP3	TIMP metallopeptidase inhibitor 3	10.9	Publications
47	LTF	lactotransferrin	10.9	Publications
48	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	10.9	Publications
49	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	10.9	Publications
50	MCM8	minichromosome maintenance complex component 8	10.9

Pathways related to gingivitis according to GeneDecks:

(show top 50)    (show all 253)

id	Pathway	Score	Top Affiliating Genes
1	Transendothelial Migration of Leukocytes36	13.4	BTK, VCAM1, MYLK, RAC1, SDC1, LAMA5
2	PAK Pathway36	12.7	BTK, MYLK, BMP2, BMP6, RAC1, LIF
3	Inhibition of Matrix Metalloproteinases36	12.6	MMP1, MMP10, MMP11, MMP13, MMP14, MMP2
4	Cell adhesion ECM remodeling10	12.5	SERPINE1, LAMC2, ITGA1, ITGA5, ITGB1, MMP1
5	Cell adhesion_ECM remodeling41	12.5	SERPINE1, LAMC2, ITGA1, ITGA5, ITGB1, MMP1
6	p38 Signaling36	12.2	BTK, BMP2, BMP6, BMPR1A, RAC1, LIF
7	Metalloproteases in connective tissue degradation10	12.2	LAMC2, CDH1, MMP1, MMP10, MMP13, MMP14
8	Molecular Mechanisms of Cancer36	12.0	PIK3CG, BTK, MYC, BMP2, BMP6, BMPR1A
9	Rap1 Pathway36	11.7	BMP2, BMP6, ITGA1, ITGA2, ITGA3, ITGA5
10	Activation of Matrix Metalloproteinases38	11.7	MMP1, MMP10, MMP11, MMP13, MMP14, MMP2
11	Bacterial infections in CF airways41	11.7	MYD88, CHUK, MUC1, LBP, IRAK1, CTSB
12	RAR-Gamma-RXR-Alpha Degradation36	11.6	BTK, BMP2, LIF, IL11, IL15, IL16
13	Cytokine production by Th17 cells in CF (Mouse model)41	11.6	MYD88, CHUK, LBP, CD14, IL12B, IL17A
14	PEDF Induced Signaling36	11.5	BTK, SERPINF1, BMP2, BMP6, LIF, BCL2
15	Th17 Differentiation37	11.5	IL12B, IL17A, IL1B, IL22, IL6, IL6R
16	Angiogenesis3	11.4	KDR, ITGA5, ITGA6, ITGAV, ITGB1, ITGB3
17	Immune response_Bacterial infections in normal airways41	11.4	MYD88, CHUK, LBP, CD14, IRAK1, IL1B
18	TRAF Pathway36	11.4	MYD88, CHUK, JUN, FOS, IRAK1, IRAK3
19	Regulation of actin cytoskeleton20	11.3	VCL, MYLK, CDC42, ITGA1, ITGA2, ITGA3
20	Toll-Like Receptor Signaling Pathways37	11.3	MYD88, CHUK, JUN, CD36, CD14, FOS
21	Toll-Like Receptors Pathway36	11.2	BTK, MYD88, RAC1, CHUK, LBP, JUN
22	Paxillin Interactions36	11.1	VCL, BMP2, RAC1, KDR, CDC42, ITGA1
23	Pertussis20	11.1	MYD88, JUN, CD14, ITGA5, ITGAM, ITGB1
24	TREM1 Pathway36	11.0	MYD88, CHUK, JUN, FOS, IRAK1, IRAK3
25	cAMP Pathway36	11.0	BMP2, BMP6, KDR, FGF14, FGF2, FGF4
26	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	11.0	BGLAP, JUN, FOS, IL1A, IL1B, IL6
27	Immune response MIF-mediated glucocorticoid regulation10	11.0	VCAM1, CHUK, JUN, MMP1, FOS, MIF
28	GSK3 Signaling36	10.9	BMP2, BMP6, KDR, CDH3, CDH1, FGF14
29	Inflammasome Activation Pathways37	10.9	MYD88, CHUK, JUN, FOS, IL18, IL1B
30	p53 Mediated Apoptosis36	10.9	BMP2, BMP6, KDR, BCL2, CHEK2, FGF14
31	Cellular Apoptosis Pathway36	10.8	VDAC1, BMP2, BMP6, KDR, BCL2, CHEK2
32	Chemokine signaling pathway20	10.8	PIK3CG, RAC1, CHUK, CDC42, IL8, MAPK3
33	p70S6K Signaling36	10.7	BMP2, BMP6, RAC1, KDR, CD19, INS
34	HGF Pathway36	10.7	RAC1, JUN, CDC42, ITGA1, ITGA2, ITGA3
35	TNF Superfamily Pathway36	10.7	CHUK, JUN, FOS, MAPK8, MAPK14, MAPK10
36	Breast Cancer Regulation by Stathmin136	10.7	BMP2, RAC1, CDC42, FGF14, FGF2, FGF4
37	Pancreatic Adenocarcinoma36	10.7	BMP2, BMP6, RAC1, KDR, BCL2, CDKN1A
38	Colorectal cancer20	10.6	PIK3CG, RAC1, FOS, MAPK8, MAPK9, MAP2K1
39	Mucin expression in CF via TLRs, EGFR signaling pathways41	10.6	MYD88, CHUK, JUN, FOS, IRAK1, IL6
40	GPCR Pathway36	10.5	BMP2, BMP6, RAC1, KDR, CHUK, JUN
41	NFAT Signaling and Lymphocyte Interactions36	10.5	BTK, BMP2, BMP6, BCL2, FCER2, IL11
42	Chemokine Signaling36	10.5	JUN, FOS, IL8, MAPK8, MAPK3, MAPK14
43	Th1 Differentiation37	10.5	JUN, FOS, IL10, IL12B, IL18, IL2
44	Osteoclast differentiation20	10.4	PIK3CG, BTK, RAC1, CHUK, JUN, ITGB3
45	Tuberculosis20	10.3	MYD88, BCL2, LBP, CEBPB, CD209, CD14
46	Activation of PKA through GPCR36	10.3	BMP2, BMP6, KDR, CHUK, FGF14, FGF2
47	HMGB1 Pathway36	10.3	RAC1, JUN, CDC42, FOS, IL1A, IL1B
48	Development_EGFR signaling pathway41	10.2	MYC, RAC1, CHUK, JUN, MMP2, MMP9
49	Development_HGF signaling pathway41	10.2	RAC1, SDC1, JUN, CDH1, FOS, FAS
50	Pathways in cancer20	8.2	PIK3CG, VEGFA, MYC, BMP2, RAC1, BCL2

Compounds related to gingivitis according to GeneDecks:

(show top 50)    (show all 485)

id	Compound	Score	Top Affiliating Genes
1	vegf32	14.0	PIK3CG, PCNA, SELE, SETD2, SERPINF2, SERPINH1
2	estrogen32	13.7	PCNA, SETD2, SERPINB2, SERPINE1, SERPINA3, VIP
3	hydrogen32 18	14.5	CNR2, BTK, SERPINB2, LPO, RAC1, S100A1
4	chondroitin sulfate32 18	14.1	VIM, BMP6, CD36, IVL, MMP13, MMP3
5	indomethacin32 9 9	14.8	CNR1, PCNA, SELL, VIM, VIP, MYC
6	hydroxyproline32 18	13.8	BMP6, BGLAP, CD36, ITGB1, MMP1, MMP13
7	glyceraldehyde 3-phosphate32	12.7	SETD2, VDAC1, SAT1, S100A9, B2M, MMP1
8	nacl32	12.4	SERPINA3, VDAC1, LIF, CHUK, S100A1, ITGA2
9	progesterone32 42 9 18 9	16.1	PCNA, SETD2, SERPINB2, SERPINA3, BSG, VCL
10	ns 39832 42	12.9	PIK3CG, PCNA, BGLAP, PARP1, MMP1, FGF2
11	polysaccharide32	11.8	SELE, SELL, SERPINF2, SERPINA3, VDAC1, VCAM1
12	polymyxin b32	11.7	SELE, SERPINE1, VDAC1, VCAM1, LBP, CD14
13	hyaluronic acid32 18	12.7	VIM, MYC, BMP6, RAC1, MUC1, B2M
14	vitamin d32	11.6	SERPINE1, VIM, BMP2, BMP6, BGLAP, B2M
15	xanthine32 18	12.6	LPO, MYLK, MPO, CD14, MMP8, IGKV2D-29
16	genistein32 9 18 9	14.3	PIK3CG, PCNA, BTK, SELE, SELL, SETD2
17	cyclophosphamide32 34 9 9	14.3	MS4A1, ITGAL, LTF, TAC1
18	methylcellulose32	11.2	VCL, BMP2, LIF, CD14, CDH1, IVL
19	budesonide32 42 9 9	14.1	BGLAP, CD36, F2RL1, PTGS1, LTF
20	nicotine32 34 9 9	14.1	SELL, BMP2, IVL, GPT, PTHLH, CYP2C19
21	carbachol32 9 9	13.1	IL11, MAPK10, F2RL1, HSPG2, TRPC4, CTSB
22	bromodeoxyuridine32	11.0	PCNA, BTK, VIM, MYC, BMP6, CDKN1A
23	vitamin b1232	10.9	PCNA, SERPINA3, B2M, MPO, CD79A, CD40LG
24	threonine32	10.8	BTK, MYLK, BMP2, BMPR1A, BDKRB2, CDC42
25	ccl332	10.8	MMP9, IL10, IL11, IL13, IL15, IL18
26	gp 13032	10.8	BTK, VIP, BMP6, LIF, CEBPB, IL13
27	anandamide32 18	11.7	CNR1, CNR2, IL4, CCL3, F2R, ALOX5
28	u012632 42	11.7	PIK3CG, JUN, MMP1, IL6, IL8, MAPK8
29	prednisolone32 9 9	12.7	SELL, VIP, VCAM1, MYC, BMP6, BGLAP
30	gf 109203x32 42	11.7	PIK3CG, BTK, VEGFA, VCL, JUN, CDKN1A
31	sp 60012532 42	11.6	PIK3CG, VCAM1, CDKN1A, CD40, MMP1, MMP13
32	fatty acid32	10.6	LPO, MYD88, CHUK, S100A8, S100A9, CDKN2A
33	mycophenolate mofetil32 9 9	12.4	SELE, SERPINE1, CD79A, CD36, CD40LG, CD40
34	quercetin32 42 9 18 9	14.3	PIK3CG, SELE, LPO, VCAM1, PARP1, BCL2
35	troglitazone32 42 9 9	13.1	PIK3CG, SELE, SERPINE1, VCAM1, BMP6, BCL2
36	4-hydroxynonenal32 18	10.9	MYC, PARP1, CHAT, CHUK, MPO, JUN
37	ciglitazone32	9.9	SERPINE1, PARP1, JUN, CDKN1A, MMP2, MMP9
38	staurosporin32	9.9	PIK3CG, BCL2, JUN, ITGAL, IL8, MAPK14
39	morphine32 9 9	11.9	CNR1, VIP, MIF, GUSB, IL1RN, MAPK10
40	rotenone32	9.9	PIK3CG, PARP1, BCL2, IL1A, IL1RAPL2, ANGPT1
41	adpribose32	9.4	PIK3CG, PCNA, PARP1, CDKN1A, GSN, FASLG
42	wortmannin32 42	10.3	PIK3CG, BTK, SETD2, VIM, VCAM1, VCL
43	butyrate32	9.3	PCNA, SETD2, VIM, MYC, BMP6, BCL2
44	camptothecin32 42 9 9	12.2	PIK3CG, PCNA, SETD2, MYC, PARP1, KDR
45	cd 43732	8.5	MYC, PARP1, BCL2, JUN, CDKN1A, FOS
46	imatinib32 34 9 9	11.5	PIK3CG, SELL, VIP, VEGFA, MYC, BMP6
47	paclitaxel32 34 9 9	11.1	PIK3CG, PCNA, SETD2, VIM, VEGFA, MYC
48	docetaxel32 34 9 9	10.8	SETD2, VEGFA, MYC, PARP1, KDR, BCL2
49	resveratrol32 9 18 9	10.6	PIK3CG, PCNA, BSG, VEGFA, BMP2, PARP1
50	suberoylanilide hydroxamic acid32	7.0	MYC, PARP1, BCL2, CDKN1A, CDH1, FASLG

Cellular components related to gingivitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	17.0	MMP1, BGLAP, BMP2, VCL, VEGFA, VIP
2	plasma membrane	GO:005886	15.5	TGFBR1, ACE, ABCB1, EGFR, EGF, EDNRB
3	extracellular space	GO:005615	15.4	CTSG, TNC, HMOX1, HMGB1, CALCA, HSPD1
4	integral to plasma membrane	GO:005887	13.3	F2RL3, FCER2, FCAR, MMP14, ITGB3, ITGAV
5	cell surface	GO:009986	12.4	CCR5, BMP2, VCAM1, VEGFA, BCAM, CD36
6	proteinaceous extracellular matrix	GO:005578	12.2	FMOD, FBN2, TNC, TNFRSF11B, SPARC, CTGF
7	platelet alpha granule lumen	GO:031093	11.2	HGF, TMSB4X, ALB, FN1, VEGFA, SERPINE1
8	external side of plasma membrane	GO:009897	11.1	CXCR3, CXCL12, CXCL10, TGFBR3, TGFBR2, THBS1
9	membrane raft	GO:045121	10.9	CASP8, CAV1, TRPC1, TNF, PTPRC, EGFR
10	cytoplasm	GO:005737	10.7	NOS2, NOD2, NOD1, PLCG1, PLAT, PLA2G6
11	cytosol	GO:005829	10.1	IDO1, MAPK8, ANPEP, FAS, FASN, IL1B

Biological processes related to gingivitis according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:006954	13.1	PIK3CG, CNR2, SELE, SERPINA3, MYD88, BMP2
2	immune response	GO:006955	12.9	CNR2, BMP6, BMPR1A, LIF, CLNK, CHUK
3	response to lipopolysaccharide	GO:032496	12.5	CNR1, CNR2, SELE, LBP, S100A8, S100A9
4	blood coagulation	GO:007596	12.3	PIK3CG, SELL, SERPINF2, SERPINB2, SERPINE1, BSG
5	response to wounding	GO:009611	12.1	RAC1, FN1, FGF7, CCR2, F2R, F2RL2
6	leukocyte migration	GO:050900	12.1	SELL, BSG, ITGA3, ITGA5, ITGA6, ITGAL
7	signal transduction	GO:007165	12.1	MYD88, RAPGEF3, BCAM, LGALS9, S100A9, ITGAL
8	positive regulation of cell proliferation	GO:008284	12.0	VIP, VEGFA, MYC, LIF, KDR, SCXA
9	extracellular matrix disassembly	GO:022617	12.0	MMP1, MMP10, MMP11, MMP13, MMP14, MMP2
10	positive regulation of interleukin-6 production	GO:032755	12.0	MYD88, LBP, CD36, IL1A, IL1B, IL6
11	platelet activation	GO:030168	11.9	PIK3CG, SERPINF2, SERPINE1, VEGFA, VCL, RAPGEF3
12	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.7	SERPINF2, BMP2, KDR, MIF, FGF2, FGF4
13	platelet degranulation	GO:002576	11.7	SERPINF2, SERPINE1, VEGFA, VCL, CD36, CD9
14	aging	GO:007568	11.6	CNR1, SERPINF1, VCAM1, JUN, GSN, IL15
15	chemotaxis	GO:006935	11.6	S100A8, S100A9, FGF2, IL4, MAPK14, MAPK1
16	positive regulation of smooth muscle cell proliferation	GO:048661	11.5	SERPINF2, MYD88, S1PR1, JUN, IL13, IL6
17	lipopolysaccharide-mediated signaling pathway	GO:031663	11.5	MYD88, LBP, IRAK1, IL18, IL1B, MAPK3
18	angiogenesis	GO:001525	11.4	PIK3CG, SETD2, SERPINE1, VEGFA, RAPGEF3, KDR
19	defense response to bacterium	GO:042742	11.3	IL10, CCL20, IFNB1, IFNG, HTN3, CAMP
20	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	11.3	MYD88, LGALS9, CHUK, CD36, CD40, IRAK1
21	response to glucocorticoid stimulus	GO:051384	11.3	SERPINF1, SERPINE1, BGLAP, IL10, IL1B, IL1RN
22	response to mechanical stimulus	GO:009612	11.2	BMP2, BGLAP, JUN, MMP9, ANGPT2, CCL2
23	negative regulation of growth of symbiont in host	GO:044130	11.2	MYD88, LBP, CD36, IL10, IL12B, IFNG
24	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.2	BTK, MYD88, CHUK, CD40, IRAK1, IRAK3
25	positive regulation of inflammatory response	GO:050729	11.1	SERPINE1, IL12B, IL15, IL18, IL2, CCR2
26	positive regulation of cell division	GO:051781	11.1	VEGFA, FGF2, FGF4, FGF7, IL1A, IL1B
27	innate immune response	GO:045087	11.1	PIK3CG, BTK, MYD88, BCL2, CHUK, LBP
28	positive regulation of tumor necrosis factor production	GO:032760	11.0	MYD88, LBP, CD36, CD14, IL12B, IL18
29	cell-cell signaling	GO:007267	10.9	BMP2, S100A9, INS, FGF14, FGF4, IL10
30	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.8	BTK, MYD88, CHUK, JUN, FOS, IRAK1
31	positive regulation of cell migration	GO:030335	10.7	VEGFA, MYLK, BMP2, KDR, S1PR1, ITGAV
32	Toll signaling pathway	GO:008063	10.7	BTK, MYD88, CHUK, LBP, JUN, CD14
33	response to drug	GO:042493	10.6	MYC, BGLAP, BDKRB2, BCL2, CHAT, B2M
34	cellular response to mechanical stimulus	GO:071260	10.6	MYD88, CD40, ITGB1, IL13, IL18, IL1B
35	toll-like receptor signaling pathway	GO:002224	10.6	BTK, MYD88, CHUK, JUN, FOS, IRAK1
36	apoptotic process	GO:006915	10.6	BTK, VIM, VDAC1, RAC1, BCL2, BCL2L2
37	negative regulation of cell proliferation	GO:008285	10.6	BMP2, LIF, BDKRB2, JUN, CDKN1A, CDKN2A
38	toll-like receptor 4 signaling pathway	GO:034142	10.6	BTK, MYD88, CHUK, JUN, CD14, FOS
39	anti-apoptosis	GO:006916	10.5	SERPINB2, MYD88, BCL2, BCL2L10, BCL2L2, MUC1
40	toll-like receptor 1 signaling pathway	GO:034130	10.5	BTK, MYD88, CHUK, JUN, FOS, IRAK1
41	toll-like receptor 2 signaling pathway	GO:034134	10.5	BTK, MYD88, CHUK, JUN, FOS, IRAK1
42	response to hypoxia	GO:001666	10.4	VEGFA, VCAM1, BMP2, BCL2, CHAT, MMP9
43	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.3	SERPINF2, SERPINE1, VEGFA, MYC, MYD88, BMP2
44	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.3	VEGFA, LIF, CD36, ITGA5, ITGB1, ITGB3
45	positive regulation of apoptotic process	GO:043065	10.3	CNR1, BMP2, ITGA6, ITGB1, MMP9, IL1B
46	TRIF-dependent toll-like receptor signaling pathway	GO:035666	10.2	CHUK, JUN, CD14, FOS, IRAK1, MAPK8
47	response to ethanol	GO:045471	10.2	CNR1, BGLAP, BCL2, CHAT, S100A8, S100A9
48	toll-like receptor 3 signaling pathway	GO:034138	10.1	CHUK, JUN, CD14, FOS, IRAK1, MAPK8
49	wound healing	GO:042060	9.8	S100A8, ITGB3, FMOD, INS, FGF2, FGF7
50	negative regulation of apoptotic process	GO:043066	8.3	PIK3CG, SERPINE1, VEGFA, MYC, BDKRB2, KDR

Molecular functions related to gingivitis according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	heparin binding	GO:008201	12.0	CTGF, CTSG, LTF, ELANE, HBEGF, THBS1
2	growth factor activity	GO:008083	11.7	GDNF, GPI, IL7, IL6, IL4, IL2
3	cytokine activity	GO:005125	11.5	VEGFA, CSF3, OSM, IL2, IL1B, IL1A
4	protein binding	GO:005515	11.3	GGT1, STAT3, DPP4, TGM2, TGFBR3, TGFBR2
5	collagen binding	GO:005518	11.3	PDGFA, PDGFB, ACHE, DSPP, DPP4, DCN
6	chemokine activity	GO:008009	11.2	CXCL1, CXCL10, CXCL11, CXCL12, CXCL16, CXCL5
7	receptor binding	GO:005102	11.1	TGFB2, LTA, NOS2, TNFSF14, TNC, CAV1
8	protein heterodimerization activity	GO:046982	9.8	SMC3, PDGFA, PDGFB, EGFR, HEXA, TYR
9	protein homodimerization activity	GO:042803	9.4	PDGFA, NFKB1, NOS2, NOD1, CRP, SMAD3
10	protease binding	GO:002020	8.9	TP53, TNF, ELANE, DPP4, CST3, CSTA