MCID: GNG013
MIFTS: 56

Gingivitis malady

Gastrointestinal category

Summaries for Gingivitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Gingivitis (\"inflammation of the gum tissue\") is a non-destructive periodontal disease. The most... more...

MalaCards: Gingivitis, also known as chronic gingivitis, is related to gingival recession and fibromatosis, gingival. An important gene associated with Gingivitis is SOS1 (son of sevenless homolog 1 (Drosophila)), and among its related pathways are GPCR Pathway and Akt Signaling. The drug carbamide peroxide and the compounds retinoic acid and lactate have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Gingivitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

gingivitis 8 10 45 61
chronic gingivitis 8 45 61
acute gingivitis 8 61
chronic gingivitis nos 8
gingivitis nos 8


Related Diseases for Gingivitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gingivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 414)
idRelated DiseaseScoreTop Affiliating Genes
1gingival recession31.6DSPP
2fibromatosis, gingival31.2SOS1, CD36, MMP1, TGFB1
3aggressive periodontitis30.8IL1A, MMP8, MMP1
4arthritis30.4TIMP1, CTSB, GUSB, IL1A, IL1B, MMP3
5squamous cell carcinoma30.4TIMP1, CTSB, FGF7, MMP3, MMP1, TGFB1
6acute leukemia30.4LPO
7pemphigus vulgaris30.2IL1A
8cleft palate30.2DSPP
9systemic scleroderma30.0TIMP1, CD36, IL1A, MMP3, MMP1, TGFB1
10osteoporosis30.0CD36, MMP3, MMP8, TGFB1
11adenocarcinoma29.9TIMP1, CTSB, GUSB, FGF7, TGFB1
12pulpitis29.9TIMP1, DSPP, IL1A, MMP1
13keloids29.9CD36, MMP8, MMP1, TGFB1
14oral submucous fibrosis29.9MMP1, TIMP1
15down syndrome29.9DSPP
16leukopenia29.9GUSB
17atherosclerosis29.7TIMP1, CD36, IL1A, IL1B, MMP3, MMP8
18colorectal cancer29.6TGFB1, MMP1, FGF7, GUSB, CTSB, TIMP1
19arthropathy29.6TIMP1, IL1B, MMP3, MMP1
20localized scleroderma29.6CD36, MMP1
21lung giant cell carcinoma29.6TIMP1, TGFB1
22familial mediterranean fever29.6IL1B
23fabry disease29.6GUSB
24amyloidosis29.6CTSB
25necrotizing ulcerative gingivitis10.8
26fibromatosis10.8
27gingival hypertrophy10.6
28lichen planus10.4
29gingival fibromatosis with hypertrichosis10.4
30granular cell tumor10.4
31congenital granular cell tumor10.3
32oral lichen planus10.3
33vulvovaginal gingival syndrome10.3
34congenital epulis10.3
35gingival fibromatosis, 210.3
36mental retardation10.3
37amelogenesis imperfecta10.2
38mucous membrane pemphigoid10.2
39cicatricial pemphigoid10.2
40stomatitis10.2
41laband syndrome10.2
42gingival fibromatosis, 110.2
43gingival fibromatosis, 310.2
44gingival fibromatosis, 410.2
45keratosis focal palmoplantar gingival10.2
46amelogenesis imperfecta and gingival fibromatosis syndrome10.2
47wegener's granulomatosis10.2
48pemphigus10.2
49jones syndrome10.2
50choristoma10.2

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to gingivitis

Clinical Features for Gingivitis

Drugs & Therapeutics for Gingivitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gingivitis

Drug clinical trials:

Search ClinicalTrials for Gingivitis

Search NIH Clinical Center for Gingivitis

Search CenterWatch for Gingivitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Gingivitis

Anatomical Context for Gingivitis

Animal Models for Gingivitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gingivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8TGFB1, TIMP1, SOS1, CTSB, CD36, FGF7
2MP:000537611.2ELANE, FGF7, CD36, GUSB, CTSB, SOS1
3MP:000200610.9TIMP1, CTSB, IL1B, MMP8, ELANE, TGFB1

Publications for Gingivitis

Sources:
51PubMed
See all sources

Articles related to Gingivitis:

(show top 50)    (show all 626)
idTitleAuthorsYear
1
Unexpected resilience to experimental gingivitis of subepithelial connective tissue grafts in gingival recession defects: a clinical-molecular evaluation. (24117898)
2013
2
Effect of periodontal therapy on serum C-reactive protein levels in patients with gingivitis and chronic periodontitis: a clinicobiochemical study. (23811651)
2013
3
A review of factors influencing the incidence and severity of plaque-induced gingivitis. (23828258)
2013
4
A 12-week clinical comparison of an oscillating-rotating power brush versus a marketed sonic brush with self-adjusting technology in reducing plaque and gingivitis. (24282870)
2013
5
A case of juvenile spongiotic gingivitis. (24353815)
2013
6
Metagenomic analysis of the peri-implant and periodontal microflora in patients with clinical signs of gingivitis or mucositis. (21538072)
2012
7
Efficacy of a herbal extract gel in the treatment of gingivitis: A clinical study. (22707865)
2012
8
White-spot lesions and gingivitis microbiotas in orthodontic patients. (22837552)
2012
9
The phylum Synergistetes in gingivitis and necrotizing ulcerative gingivitis. (22878253)
2012
10
The addition of a water flosser to power tooth brushing: effect on bleeding, gingivitis, and plaque. (22779218)
2012
11
Multiple Hypothesis Testing for Experimental Gingivitis Based on Wilcoxon Signed Rank Statistics. (21984957)
2011
12
Comparison between the Efficacy of Herbal and Conventional Dentifrices on Established Gingivitis. (22013464)
2011
13
Poor oral hygiene and gingivitis are associated with obesity and overweight status in paediatric subjects. (21793868)
2011
14
Toll like receptor 4 and membrane-bound CD14 expressions in gingivitis, periodontitis and CsA-induced gingival overgrowth. (21146153)
2011
15
Desquamative gingivitis as a manifestation of chronic mucocutaneous disease. (21050381)
2011
16
Professional oral hygiene as a therapeutic option for pediatric patients with plasma cell gingivitis: preliminary results of a prospective case series. (21563944)
2011
17
Gingival tissue transcriptomes in experimental gingivitis. (21501207)
2011
18
The arginine-deiminase enzymatic system on gingivitis: preliminary pediatric study. (22238699)
2010
19
Limited benefit of copaifera oil on gingivitis progression in humans. (20098967)
2010
20
Application of the gingival contour plaque index: six-month plaque and gingivitis study. (19476084)
2009
21
Prevalence of gingivitis among school attendees in Qazvin, Iran. (20000025)
2009
22
Effect of various mouthwashes on the levels of interleukin-2 and interferon-gamma in chronic gingivitis. (18389675)
2008
23
Risk indicators of gingivitis in 5-year-old Brazilian children. (18637390)
2008
24
Effect of three different dental health preventive programmes on young adult individuals: a randomized, blinded, parallel group, controlled evaluation of oral hygiene behaviour on plaque and gingivitis. (17448044)
2007
25
Juvenile spongiotic gingivitis. (17608578)
2007
26
Clinical effect of a triclosan containing dentifrice on gingivitis during pregnancy and post-partum. (17121312)
2006
27
Inhibition of experimental gingivitis in beagle dogs with topical mercaptoalkylguanidines. (16512752)
2006
28
Gingivitis susceptibility and its relation to periodontitis in men. (17122168)
2006
29
Distribution of plaque and gingivitis and associated factors in 3- to 5-year-old Brazilian children. (16734306)
2006
30
Efficacy of a herbal toothpaste on patients with established gingivitis--a randomized controlled trial. (16878213)
2006
31
A 6-month clinical trial to study the effects of a cetylpyridinium chloride mouthrinse on gingivitis and plaque. (16178130)
2005
32
The clinical application of hyaluronic acid in gingivitis therapy. (15999421)
2005
33
An experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice. (16296255)
2004
34
Use of anti-inflammatory medications in managing atypical gingivitis associated with hypermobile Ehlers-Danlos syndrome: a case report. (15633333)
2004
35
Modulation of clinical expression of plaque-induced gingivitis. III. Response of "high responders" and "low responders" to therapy. (15016252)
2004
36
Prevalence of gingivitis in 6- to 11-year-old Croatian children. (12911869)
2003
37
A method to compare four mouthrinses: time to gingivitis level as the primary outcome variable. (12296779)
2002
38
Oral pemphigoid masquerading as necrotizing ulcerative gingivitis in a child. (12083540)
2002
39
Plasma cell gingivitis. (11829177)
2002
40
Changes in crevicular fluid levels of interleukin-1 beta, leukotriene B4, prostaglandin E2, thromboxane B2 and tumour necrosis factor alpha in experimental gingivitis in humans. (8101565)
1993
41
Linear IgA disease manifesting as recalcitrant desquamative gingivitis. (1508525)
1992
42
Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis. (1610303)
1992
43
Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis. (1713299)
1991
44
Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. (3477745)
1987
45
Acute necrotizing ulcerative gingivitis in a case of systemic lupus erythematosus. (3855317)
1985
46
The bacteriology of acute necrotizing ulcerative gingivitis. (6122728)
1982
47
Treatment of acute necrotizing ulcerative gingivitis by chlorhexidine and cetrimide a clinical report--I. (1073673)
1975
48
A possible relationship between acute necrotizing ulcerative gingivitis and infectious mononucleosis. (5288705)
1971
49
Topical antibiotic treatment of acute necrotizing ulcerative gingivitis. (5264868)
1967
50
Necrotizing ulcerative gingivitis. (15430197)
1950

Genetic Variations for Gingivitis

Expression for genes affiliated with Gingivitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gingivitis

Search GEO for disease gene expression data for Gingivitis.

Pathways for genes affiliated with Gingivitis

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Gingivitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4TIMP1, SOS1, FGF7, MMP3, MMP8, MMP1
2
Hide members
11.2TIMP1, SOS1, FGF7, IL1A, IL1B, TGFB1
3
Hide members
11.2SOS1, CTSB, CD36, FGF7, IL1A, IL1B
4
Hide members
11.1SOS1, CD36, MMP3, MMP8, MMP1
5
Hide members
11.1SOS1, FGF7, IL1A, IL1B, TGFB1
6
Hide members
11.1MMP1, MMP8, MMP3, CTSB, TIMP1
7
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.0TIMP1, SOS1, MMP3, MMP1
8
Hide members
11.0MMP1, MMP8, MMP3, TIMP1
9
Cell adhesion ECM remodeling
Hide members
11.0TIMP1, MMP3, MMP8, MMP1
10
Hide members
11.0TIMP1, CTSB, MMP3, MMP8
1110.9TGFB1, IL1B, IL1A
1210.9CD36, IL1A, IL1B
1310.9CD36, MMP8, ELANE
14
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.9MMP3, MMP1, ELANE
15
Hide members
10.9IL1B, IL1A, TIMP1
16
Immune response Bacterial infections in normal airways
Hide members
10.9IL1B, IL1A, CTSB
1710.7IL1B, IL1A
1810.7TGFB1, IL1B
19
Hide members
10.7TGFB1, ELANE
20
Hide members
10.7CD36, TIMP1
21
Hide members
10.7FGF7, TIMP1

Compounds for genes affiliated with Gingivitis

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Gingivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2413.3IL1A, FGF7, IL1B, TGFB1, MMP8, CD36
2lactate4512.2MMP3, DSPP, LPO, GUSB, CTSB, TIMP1
3vegf4512.1IL1A, CTSB, CD36, TGFB1, IL1B, TIMP1
4cysteine4512.1FGF7, MMP3, CTSB, MMP8, ELANE, MMP1
5glycosaminoglycan4512.1TIMP1, GUSB, CD36, FGF7, IL1A, MMP3
6hyaluronic acid45 2413.1CD36, IL1B, TGFB1, ELANE, TIMP1, FGF7
7genistein45 29 60 2 11 2417.0CD36, MMP1, TIMP1, GUSB, FGF7, IL1A
8serine4512.0SOS1, TIMP1, TGFB1, MMP8, MMP1, CTSB
9glutamine4511.9MMP3, ELANE, TGFB1, IL1A, TIMP1, FGF7
10doxycycline45 1112.8MMP8, TIMP1, DSPP, FGF7, MMP3, ELANE
11heparin45 29 11 2414.8MMP3, GUSB, CTSB, TIMP1, IL1A, FGF7
12h2o24511.8CD36, MMP1, MMP8, FGF7, CTSB, LPO
13tgf beta14511.8TIMP1, FGF7, MMP1, TGFB1, MMP3, IL1B
14calcitriol45 60 11 2414.8IL1A, DSPP, TGFB1, MMP1, IL1B, CD36
15ribonucleic acid4511.7FGF7, IL1A, MMP1, MMP3, IL1B, TIMP1
16sb 20358045 6012.7TIMP1, CD36, IL1B, TGFB1, IL1A, MMP1
17alendronate45 50 1113.7DSPP, TIMP1, CD36, MMP3, MMP1, MMP8
18batimastat45 60 1113.7MMP1, TIMP1, CD36, MMP3, ELANE, MMP8
19tetracycline45 1112.6MMP8, TGFB1, MMP1, IL1A, DSPP, GUSB
20paraffin4511.6MMP3, DSPP, CD36, MMP1, CTSB, TGFB1
21cyclosporin a45 29 6013.5MMP8, ELANE, MMP1, CTSB, FGF7
22curcumin4511.5TIMP1, TGFB1, MMP1, MMP3, IL1B, IL1A
23vitamin d4511.5ELANE, DSPP, MMP3, FGF7, CD36
24aspirin45 50 29 2414.5TGFB1, TIMP1, GUSB, IL1B, MMP1, ELANE
25hydroxyproline45 11 2413.4MMP1, TGFB1, TIMP1, CTSB, CD36
26(4-aminophenyl)mercuric acetate4511.4ELANE, MMP8, MMP3, TIMP1
27uva 14511.4IL1A, MMP3, MMP1, TIMP1
28rantes4511.4TGFB1, IL1A, FGF7, IL1B
29matrigel4511.3CTSB, FGF7, MMP3, MMP1
30ascorbic acid45 2412.3MMP3, IL1A, MMP1, LPO, CD36, DSPP
31pirfenidone45 6012.3TGFB1, IL1B, IL1A, CD36
32dexamethasone45 50 29 1114.3TGFB1, DSPP, TIMP1
33clodronate45 50 1113.3MMP8, MMP1, CD36, IL1B
34creatinine4511.3TGFB1, CD36, MMP1, MMP3, IL1A, CTSB
35minocycline45 1112.3IL1B, TIMP1, DSPP, IL1A
3612-o-tetradecanoylphorbol 13-acetate4511.2MMP1, IL1A, FGF7, MMP3, TIMP1, TGFB1
37aprotinin45 1112.2ELANE, MMP1, TIMP1, CTSB
38nimesulide45 1112.2TIMP1, MMP3, MMP1
39hydroxamate4511.2MMP1, MMP8, TIMP1, MMP3
40alginate4511.2ELANE, CD36
41marimastat45 60 1113.2TIMP1, MMP8, MMP3, MMP1
42leflunomide50 45 1113.1MMP1, MMP3, IL1B, TIMP1
43hydrocortisone45 2 60 1114.1ELANE, MMP1
44pge24511.1TGFB1
45procollagen4511.0TGFB1
46cycloheximide4511.0FGF7
47rhein4511.0IL1B, TGFB1, TIMP1
48indomethacin45 60 29 1113.9CTSB
49troglitazone45 29 60 1113.9IL1B, MMP1, CD36
50ns 39845 6011.7IL1A, IL1B, MMP1, TGFB1

GO Terms for genes affiliated with Gingivitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Gingivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.8TGFB1, TIMP1, FAM20A, CTSB, FGF7, IL1A
2extracellular spaceGO:00561511.4TGFB1, MMP8, MMP3, IL1B, IL1A, LPO
3proteinaceous extracellular matrixGO:00557810.8DSPP, MMP3, MMP8, MMP1, TGFB1

Biological processes related to Gingivitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.6TGFB1, ELANE, MMP8, MMP3, CTSB, TIMP1
2extracellular matrix disassemblyGO:02261711.5MMP3, TIMP1, CTSB, ELANE, MMP1, MMP8
3collagen catabolic processGO:03057411.3MMP3, MMP8, MMP1, ELANE, CTSB
4positive regulation of cell divisionGO:05178111.2FGF7, TGFB1, IL1B, IL1A
5blood coagulationGO:00759611.2CD36, TGFB1, MMP1, SOS1, TIMP1
6proteolysisGO:00650811.1ELANE, MMP8, MMP3, MMP1, CTSB
7platelet activationGO:03016811.1TGFB1, TIMP1, SOS1, CD36
8positive regulation vascular endothelial growth factor productionGO:01057511.0IL1A, IL1B, TGFB1
9fever generationGO:00166010.9IL1B, IL1A
10platelet degranulationGO:00257610.8TIMP1, CD36, TGFB1
11positive regulation of interleukin-2 biosynthetic processGO:04508610.7IL1A, IL1B
12hyaluronan catabolic processGO:03021410.4GUSB, TGFB1

Products for genes affiliated with Gingivitis

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  • Antibodies

Sources for Gingivitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet