MCID: GNG013
MIFTS: 61

Gingivitis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Gingivitis

Summaries for Gingivitis

MalaCards based summary : Gingivitis, also known as chronic gingivitis, is related to amelogenesis imperfecta and myiasis, and has symptoms including signs and symptoms, digestive, tenderness of gums and denture irritation. An important gene associated with Gingivitis is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Toll-Like receptor Signaling Pathways. The drugs Chlorhexidine and Hexetidine have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Gingivitis (\"inflammation of the gum tissue\") is a non-destructive disease that occurs around the... more...

Related Diseases for Gingivitis

Diseases related to Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 474)
id Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta 30.2 CXCL8 IL6 TNF
2 myiasis 29.9 CXCL8 IL6 TNF
3 rheumatoid arthritis 29.6 CD79A CXCL8 IL1A IL1B IL6 TNF
4 neuropathy 29.4 CXCL8 IL1B IL6 TNF
5 gingival recession 12.4
6 gingival overgrowth 12.4
7 gingival fibromatosis 12.4
8 necrotizing ulcerative gingivitis 12.3
9 hypertrichosis terminalis, generalized, with or without gingival hyperplasia 12.2
10 fibromatosis, gingival, 1 12.1
11 gingival disease 12.1
12 fibromatosis, gingival, with progressive deafness 12.0
13 focal palmoplantar and gingival keratoderma 12.0
14 gingival hypertrophy 11.9
15 vulvovaginal gingival syndrome 11.9
16 fibromatosis, gingival, 3 11.8
17 fibromatosis, gingival, 4 11.8
18 fibromatosis, gingival, 2 11.8
19 fibromatosis, gingival, with distinctive facies 11.8
20 keratosis, focal palmoplantar and gingival 11.7
21 amelogenesis imperfecta-gingival hyperplasia syndrome 11.7
22 amelogenesis imperfecta, type ig 11.6
23 epulis 11.6
24 zimmermann-laband syndrome 1 11.5
25 periodontal disease 11.4
26 congenital epulis 11.2
27 ramon syndrome 11.2
28 periodontitis 11.1
29 zimmermann-laband syndrome 11.0
30 ossifying fibroma 11.0
31 rutherfurd syndrome 10.8
32 periodontitis 1, juvenile 10.8
33 ehlers-danlos syndrome, type viii 10.8
34 hyaline fibromatosis syndrome 10.8
35 gum cancer 10.7
36 aggressive periodontitis 10.7
37 tumoral calcinosis, familial, normophosphatemic 10.7
38 kindler syndrome 10.7
39 ehlers-danlos syndrome, periodontal type 2 10.7
40 zimmermann-laband syndrome 2 10.7
41 hypertrichosis universalis congenita, ambras type 10.7
42 recombinant 8 syndrome 10.7
43 amelogenesis imperfecta, type iii 10.7
44 mental retardation, truncal obesity, retinal dystrophy, and micropenis 10.7
45 robinow syndrome, autosomal dominant 2 10.7
46 orofacial granulomatosis 10.7
47 bernard-soulier syndrome, type a2 10.7
48 craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome 10.7
49 frank-ter haar syndrome 10.7
50 oculocerebral syndrome with hypopigmentation 10.7

Comorbidity relations with Gingivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to Gingivitis

Symptoms & Phenotypes for Gingivitis

UMLS symptoms related to Gingivitis:


signs and symptoms, digestive, tenderness of gums, denture irritation

MGI Mouse Phenotypes related to Gingivitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 LTF CD79A MMP9 CTSG PLAT ELANE
2 homeostasis/metabolism MP:0005376 9.93 LTF MMP8 CD79A MMP9 PLAT ELANE
3 immune system MP:0005387 9.73 LTF MMP8 CD79A MMP9 CTSG PLAT
4 neoplasm MP:0002006 9.32 LTF CD79A MMP8 MMP9 CTSG ELANE

Drugs & Therapeutics for Gingivitis

Drugs for Gingivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 55-56-1 9552079 2713
2
Hexetidine Approved Phase 4 141-94-6
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4 sodium fluoride Approved Phase 4,Phase 3,Phase 1,Phase 2 7681-49-4
5
Triclosan Approved Phase 4,Phase 3,Phase 1,Phase 2 3380-34-5 5564
6
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
7
Menthol Approved Phase 4,Early Phase 1 2216-51-5 16666
8
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
9
Thymol Approved Phase 4 89-83-8 6989
10
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
11
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
12 Antifungal Agents Phase 4
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Cariostatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Early Phase 1
17 Dermatologic Agents Phase 4,Phase 3,Phase 2
18 Disinfectants Phase 4,Phase 3,Phase 2
19 Fluorides Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
20 Listerine Phase 4,Phase 3,Phase 1,Phase 2
21 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Anesthetics Phase 4
24 Antimetabolites Phase 4,Phase 3,Phase 2
25 Hypolipidemic Agents Phase 4,Phase 3,Phase 2
26 Lipid Regulating Agents Phase 4,Phase 3,Phase 2
27 Calcium, Dietary Phase 4
28 Caseins Phase 4
29 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1
30 Central Nervous System Depressants Phase 4
31 Cetylpyridinium Phase 4,Phase 3,Phase 2,Phase 1
32 Antioxidants Phase 4,Phase 3
33 Antiparasitic Agents Phase 4,Phase 3
34 Antiprotozoal Agents Phase 4,Phase 3
35 Vitamins Phase 4,Phase 3
36
Tin Phase 4,Phase 3 7440-31-5
37 Tin Fluorides Phase 4,Phase 3
38 Fluorophosphate Phase 4
39 Chelating Agents Phase 4
40 Salicylates Phase 4
41 Tea Tree Oil Phase 4
42 Acidophilus Nutraceutical Phase 4,Phase 3,Phase 2
43 Anthocyanidin Nutraceutical Phase 4
44 Proanthocyanidin Nutraceutical Phase 4
45
Procyanidin Nutraceutical Phase 4 4852-22-6 147299
46
Catechin Nutraceutical Phase 4 154-23-4 9064
47
Epicatechin Nutraceutical Phase 4 490-46-0 72276
48
Eucalyptol Nutraceutical Phase 4 470-82-6 2758
49 Tea Tree Nutraceutical Phase 4
50
Aminocaproic Acid Approved, Investigational Phase 3 60-32-2 564

Interventional clinical trials:

(show top 50) (show all 221)
id Name Status NCT ID Phase
1 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
2 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4
3 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
4 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
5 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Unknown status NCT02030470 Phase 4
6 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
7 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
8 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4
9 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed NCT02080273 Phase 4
10 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed NCT02366689 Phase 4
11 Essential Oil+ELA, Plaque and Gingivitis Completed NCT02884817 Phase 4
12 Evaluate Inflammation Caused by Gingivitis in Adults Completed NCT00941668 Phase 4
13 Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables Completed NCT01578603 Phase 4
14 A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease Completed NCT02065414 Phase 4
15 Effect of Mouthrinsing on Inflammation of the Gums. Completed NCT01317446 Phase 4
16 Compare Anti-inflammatory Dentifrices Completed NCT00762528 Phase 4
17 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
18 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4
19 "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. Completed NCT02154594 Phase 4
20 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4
21 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
22 Clinical Examination of Metal Free Interdental Brushes Completed NCT01593540 Phase 4
23 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
24 Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study Completed NCT01213550 Phase 4
25 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. Completed NCT02124655 Phase 4
26 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
27 Interaction Between Chlorhexidine and Fluoride Completed NCT02935322 Phase 4
28 Periodontal Treatment Response in Type II Diabetic Patients Completed NCT01881074 Phase 4
29 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Active, not recruiting NCT03099551 Phase 4
30 Treatment of Peri-implantitis Lesions by Using Biomaterial Active, not recruiting NCT02375750 Phase 4
31 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4
32 Efficacy of Different Chlorhexidine Concentrations Not yet recruiting NCT02911766 Phase 4
33 Evaluation and Comparison of Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Mouth Rinse Not yet recruiting NCT02987634 Phase 4
34 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth Not yet recruiting NCT02946801 Phase 4
35 Effect of Different Mouthrinses in Plaque Formation Not yet recruiting NCT02695901 Phase 4
36 Efficacy of a Mouthwash Containing Propolis Unknown status NCT01750801 Phase 3
37 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis Completed NCT00926328 Phase 3
38 Effects of Antioxidant Dentifrice on Gingivitis Completed NCT02102295 Phase 3
39 The Effect of Mouthrinses Containing Bamboo Salt, Magnolia Bark and Centella Asiatica on Reducing Plaque and Gingivitis Completed NCT03047798 Phase 3
40 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00964860 Phase 3
41 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis Completed NCT02193165 Phase 3
42 Flossing With Chlorhexidine Completed NCT00471783 Phase 3
43 The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis Completed NCT02616042 Phase 3
44 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes Completed NCT00762515 Phase 3
45 Effect of Probiotic Lozenge on Gingivitis and Periodontitis Completed NCT02203812 Phase 3
46 Effectiveness of Black Tea Mouthwash on Plaque Formation Completed NCT02545244 Phase 3
47 Comparing the Inter-dental Brush to Dental Floss Completed NCT00743548 Phase 3
48 Development of Inflammatory Disease Model Protein, Genetic and Microbial Biomarkers Completed NCT00980525 Phase 2, Phase 3
49 Compare the Clinical Efficacy of Prototype Toothpastes Completed NCT00926029 Phase 3
50 Compare the Clinical Efficacy of Prototype Toothpastes. Completed NCT00761930 Phase 3

Search NIH Clinical Center for Gingivitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: gingivitis

Genetic Tests for Gingivitis

Genetic tests related to Gingivitis:

id Genetic test Affiliating Genes
1 Gingivitis 29

Anatomical Context for Gingivitis

MalaCards organs/tissues related to Gingivitis:

39
Bone, Neutrophil, Monocytes, Endothelial, Heart, T Cells, Testes

Publications for Gingivitis

Articles related to Gingivitis:

(show top 50) (show all 3098)
id Title Authors Year
1
Xenogeneic Collagen Matrix Versus Connective Tissue Graft: Case Series of Various Gingival Recession Treatments. ( 27977826 )
2017
2
Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients. ( 28341818 )
2017
3
Galectin-1 expression is associated with tumour immunity and prognosis in gingival squamous cell carcinoma. ( 28108653 )
2017
4
Histologic and Clinical Study of Gingival Recession Treated with Subepithelial Connective Tissue Graft: A Case Report. ( 27977823 )
2017
5
Letter to the Editor: Re: Reducing Dental Plaque and Gingivitis With 0.6% Cortex Ilicis Rotundae Toothpaste: A Randomized, Double-Masked Clinical Trial. ( 27809632 )
2017
6
Clinical, Immune, and Microbiome Traits of Gingivitis and Peri-implant Mucositis. ( 28033066 )
2017
7
Efficacy of azithromycin and metronidazole combined therapy on rats' gingival overgrowth induced by cyclosporine-A: An experimental animal study. ( 27761387 )
2016
8
Detection of Porphyromonas gingivalis fimA Type I Genotype in Gingivitis by Real-Time PCR-A Pilot Study. ( 27504406 )
2016
9
Effectiveness of Azadirachta indica (neem) mouthrinse in plaque and gingivitis control: a systematic review. ( 26876277 )
2016
10
Treatment of Moderate to Severe Buccal Gingival Recession Defects with Placental Allografts. ( 26901295 )
2016
11
Vulvovaginal gingival lichen planus: report of two cases and review of literature. ( 28042431 )
2016
12
Isolated mucosal fenestration with localized gingival recession: Closure with an acellular dermal graft. A rare case report with two years' follow-up. ( 26824083 )
2016
13
Periosteal pedicle graft for the treatment of gingival recession defects current status and future prospects: What the evidence suggests? ( 27143840 )
2016
14
Diode Laser Versus Scalpel in the Treatment of Hereditary Gingival Fibromatosis in a 6-Year Old Boy. ( 27994842 )
2016
15
Three-year randomized study of manual and power toothbrush effects on pre-existing gingival recession. ( 26810391 )
2016
16
Resin composite plus connective tissue graft to treat single maxillary gingival recession associated with non-carious cervical lesion: randomized clinical trial. ( 26847486 )
2016
17
Comparative Evaluation of Triphala and Ela Decoction With 0.2% Chlorhexidine as Mouthwash in the Treatment of Plaque-Induced Gingivitis and Halitosis: A Randomized Controlled Clinical Trial. ( 27932522 )
2016
18
Clinical effects of probiotics containing Bacillus species on gingivitis: a pilot randomized controlled trial. ( 27859252 )
2016
19
Bristle splaying and its effect on pre-existing gingival recession-a 12-month randomized controlled trial. ( 27796575 )
2016
20
Candidal Infection of the Gingiva Mimicking Desquamative Gingivitis: A Case Report. ( 27135011 )
2016
21
Desquamative gingivitis as only presenting sign of mucous membrane pemphigoid. ( 27563211 )
2016
22
Esthetic dentistry for multiple gingival recession cases: Coronally advanced flap with bracket application. ( 27143837 )
2016
23
Gingivitis from the Viewpoint of Traditional Persian Medicine. ( 27516668 )
2016
24
2-Year Assessment of Tissue Bioestimulation With Low-Level Laser on the Outcomes of Connective Tissue Graft in the Treatment of Single Gingival Recession. Randomized Clinical Trial. ( 27834120 )
2016
25
Eugenia uniflora Dentifrice for Treating Gingivitis in Children: Antibacterial Assay and Randomized Clinical Trial. ( 27652698 )
2016
26
Coughing up - Small cell carcinoma lung with gingival metastasis. ( 27769796 )
2016
27
Dynamics of red fluorescent dental plaque during experimental gingivitis-A cohort study. ( 26921667 )
2016
28
Gingival Crevicular Fluid and Saliva Stress Hormone Levels in Patients with Chronic and Aggressive Periodontitis. ( 27513682 )
2016
29
Combined Regenerative and Mucogingival Treatment of Deep Intrabony Defects Associated with Buccal Gingival Recession: Two Case Reports. ( 27740647 )
2016
30
Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1I^ and the danger signals ASC and HMGB1. ( 26687842 )
2016
31
Gingival Crevicular Fluid and Plasma Levels of Transglutaminase-2 and Oxidative Stress Markers in Cylosporin A-Induced Gingival Overgrowth. ( 27468796 )
2016
32
Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells. ( 27744428 )
2016
33
Comparative evaluation of management of gingival recession using subepithelial connective tissue graft and collagen membrane by periodontal microsurgical technique: A clinical study of 40 cases. ( 27143833 )
2016
34
Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. ( 27599778 )
2016
35
Evaluation of melatonin levels in saliva in gingivitis and periodontitis cases: A pilot study. ( 27994421 )
2016
36
Prevalence and treatment of necrotizing ulcerative gingivitis (NUG) in the British Armed Forces: a case-control study. ( 27830369 )
2016
37
"Triphala" - A New Herbal Mouthwash in Gingivitis: A Randomized Controlled Clinical Trial. ( 27442086 )
2016
38
Epidemiology of gingivitis in schoolchildren in Bucharest, Romania: a cross-sectional study. ( 27093564 )
2016
39
Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft. ( 26696115 )
2016
40
Assessment of non-carious root surface defects in areas of gingival recession: A descriptive study. ( 27703607 )
2016
41
Idiopathic Gingival Fibromatosis: Case Report and Review of the Literature. ( 27043333 )
2016
42
The effect of a triclosan/copolymer/fluoride a8"toothpaste on plaque formation, gingivitis, and a8"dentin hypersensitivity: A single-blinded a8"randomized clinical study. ( 27981268 )
2016
43
Upregulation of Slug expression by cyclosporine A contributes to the pathogenesis of gingival overgrowth. ( 27287534 )
2016
44
Effect of Sleep and Salivary Glucose on Gingivitis in Children. ( 27470068 )
2016
45
Cimetidine Reduces Interleukin-6, Matrix Metalloproteinases-1 and -9 Immunoexpression in the Gingival Mucosa of Rat Molars With Induced Periodontal Disease. ( 27587368 )
2016
46
Efficacy of fluoride varnish for preventing white spot lesions and gingivitis during orthodontic treatment with fixed appliances-a prospective randomized controlled trial. ( 26832780 )
2016
47
Coronally Advanced Flap with Different Designs in the Treatment of Gingival Recession: A Comparative Controlled Randomized Clinical Trial. ( 27100801 )
2016
48
Gingival recession coverage: a8"Do we still need autogenous grafts? ( 27660847 )
2016
49
Clinical efficacy of a 1% Matricaria chamomile L. mouthwash and 0.12% chlorhexidine for gingivitis control in patients undergoing orthodontic treatment with fixed appliances. ( 28025442 )
2016
50
Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis. ( 27129587 )
2016

Variations for Gingivitis

Expression for Gingivitis

Search GEO for disease gene expression data for Gingivitis.

Pathways for Gingivitis

Pathways related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CD79A CTSG CXCL8 DEFB4A ELANE GUSB
2
Show member pathways
12.95 CXCL8 IL1A IL1B IL6 TNF
3
Show member pathways
12.88 CXCL8 IL1B IL6 MMP9 TNF
4
Show member pathways
12.84 CXCL8 IL1A IL1B IL6 TNF
5
Show member pathways
12.78 CXCL8 IL1A IL1B IL6 TNF
6
Show member pathways
12.56 IL1A IL1B IL6 TNF
7
Show member pathways
12.42 IL1A IL1B IL6 TNF
8
Show member pathways
12.36 CTSG DEFB4A ELANE LTF
9
Show member pathways
12.32 IL1B IL6 PLAT TNF
10
Show member pathways
12.31 CXCL8 IL1A IL1B IL6 TNF
11
Show member pathways
12.29 CXCL8 DEFB4A IL1B IL6 MMP9 TNF
12 12.28 CXCL8 ELANE IL6 MMP9 PLAT
13
Show member pathways
12.26 CXCL8 IL1A IL6 TNF
14 12.23 IL1A IL1B IL6 TNF
15
Show member pathways
12.23 CXCL8 DEFB4A IL1B IL6 TNF
16 12.22 CXCL8 IL1A IL1B IL6 TNF
17
Show member pathways
12.17 CXCL8 IL1A IL1B IL6 TNF
18 12.12 IL1A IL1B MMP9 PLAT TNF
19 11.98 IL1B IL6 MMP9 TNF
20 11.96 CD79A IL6 TNF
21 11.93 IL1A IL1B IL6 TNF
22 11.93 CXCL8 IL1A IL1B IL6 TNF
23
Show member pathways
11.92 IL1B IL6 TNF
24
Show member pathways
11.92 CTSG ELANE MMP8 MMP9 TNF
25 11.87 CXCL8 IL1A IL1B IL6
26 11.87 CTSG CXCL8 IL1B IL6 TNF
27 11.86 CXCL8 IL1B TNF
28 11.81 CXCL8 IL1A IL1B IL6 TNF
29 11.81 CXCL8 IL1A IL1B IL6 MMP9 TNF
30 11.76 IL1B IL6 TNF
31 11.71 CXCL8 IL1A IL1B IL6 TNF
32 11.69 CXCL8 IL1A IL1B IL6 MMP9 TNF
33 11.68 CXCL8 IL6 MMP9
34 11.64 CXCL8 MMP9 PLAT
35 11.64 CXCL8 IL1B IL6 TNF
36 11.6 CXCL8 IL1B IL6 MMP9 TNF
37 11.58 CXCL8 IL1B IL6 TNF
38 11.53 IL1B SERPINB2 TNF
39 11.53 IL1A IL1B IL6
40 11.53 IL1A IL1B IL6 TNF
41 11.46 CXCL8 IL1A IL1B IL6 TNF
42 11.46 CXCL8 IL1A IL1B IL6 PLAT SERPINB2
43 11.4 ELANE IL6 MMP9 PLAT TNF
44 11.39 IL1B IL6 TNF
45 11.39 IL1A IL1B IL6 TNF
46 11.38 IL1A IL1B IL6
47 11.37 CXCL8 IL6 MMP9
48 11.34 IL1B IL6 TNF
49 11.32 IL1B IL6 TNF
50 11.29 IL1A IL1B IL6 TNF

GO Terms for Gingivitis

Cellular components related to Gingivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CTSG CXCL8 DEFB4A ELANE GUSB IL1A
2 cell surface GO:0009986 9.77 CTSG ELANE LTF PLAT TNF
3 extracellular matrix GO:0031012 9.73 CTSG MMP8 MMP9 PLAT
4 azurophil granule lumen GO:0035578 9.58 CTSG ELANE GUSB
5 secretory granule GO:0030141 9.55 CTSG ELANE IL1B LTF PLAT
6 specific granule lumen GO:0035580 9.5 ELANE LTF MMP8
7 extracellular space GO:0005615 9.47 CTSG CXCL8 DEFB4A ELANE GUSB IL1A
8 tertiary granule lumen GO:1904724 9.43 LTF MMP8 MMP9

Biological processes related to Gingivitis according to GeneCards Suite gene sharing:

(show all 43)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 IL1A IL1B IL6 TNF
2 inflammatory response GO:0006954 9.97 CXCL8 IL1A IL1B IL6 TNF
3 neutrophil degranulation GO:0043312 9.93 CTSG ELANE GUSB LTF MMP8 MMP9
4 leukocyte migration GO:0050900 9.92 ELANE IL1B MMP9 TNF
5 response to lipopolysaccharide GO:0032496 9.9 CTSG ELANE IL1B IL6
6 positive regulation of angiogenesis GO:0045766 9.85 CXCL8 IL1A IL1B
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL1B IL6 TNF
8 defense response to bacterium GO:0042742 9.83 CTSG DEFB4A ELANE LTF TNF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B IL6 LTF TNF
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 ELANE IL6 TNF
11 humoral immune response GO:0006959 9.78 IL6 LTF TNF
12 cellular response to lipopolysaccharide GO:0071222 9.78 CTSG CXCL8 IL6 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IL1B IL6 TNF
14 extracellular matrix disassembly GO:0022617 9.71 CTSG ELANE MMP8 MMP9
15 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.69 IL1A IL1B TNF
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.68 MMP9 TNF
18 positive regulation of chemokine production GO:0032722 9.68 IL6 TNF
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 IL1B TNF
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
22 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.66 IL1A IL1B
23 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
24 positive regulation of immune response GO:0050778 9.65 CTSG ELANE
25 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
26 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.65 ELANE TNF
27 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.64 IL1A IL1B
28 ectopic germ cell programmed cell death GO:0035234 9.64 IL1A IL1B
29 response to yeast GO:0001878 9.63 ELANE IL6
30 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
31 defense response to Gram-positive bacterium GO:0050830 9.62 CTSG DEFB4A IL6 TNF
32 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.61 IL6 TNF
33 positive regulation of fever generation GO:0031622 9.59 IL1B TNF
34 sequestering of triglyceride GO:0030730 9.57 IL1B TNF
35 antimicrobial humoral response GO:0019730 9.56 CTSG DEFB4A ELANE LTF
36 negative regulation of chemokine biosynthetic process GO:0045079 9.55 ELANE IL6
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IL1B TNF
38 negative regulation of growth of symbiont in host GO:0044130 9.54 CTSG ELANE TNF
39 fever generation GO:0001660 9.52 IL1A IL1B
40 defense response to Gram-negative bacterium GO:0050829 9.46 CTSG DEFB4A IL6 LTF
41 positive regulation of interleukin-6 production GO:0032755 9.26 IL1A IL1B IL6 TNF
42 immune response GO:0006955 9.17 CTSG CXCL8 DEFB4A IL1A IL1B IL6
43 proteolysis GO:0006508 10.06 CTSG ELANE LTF MMP8 MMP9 PLAT

Molecular functions related to Gingivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.87 CTSG ELANE GUSB LTF MMP8 MMP9
2 peptidase activity GO:0008233 9.63 CTSG ELANE LTF MMP8 MMP9 PLAT
3 serine-type peptidase activity GO:0008236 9.56 CTSG ELANE LTF PLAT
4 interleukin-1 receptor binding GO:0005149 9.37 IL1A IL1B
5 cytokine activity GO:0005125 9.35 CXCL8 IL1A IL1B IL6 TNF
6 serine-type endopeptidase activity GO:0004252 9.1 CTSG ELANE LTF MMP8 MMP9 PLAT

Sources for Gingivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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