MCID: GNG013
MIFTS: 67

Gingivitis malady

Gastrointestinal diseases category

Summaries for Gingivitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gingivitis (\"inflammation of the gum tissue\") is a non-destructive periodontal disease. The most... more...

MalaCards: Gingivitis, also known as chronic gingivitis, is related to periodontitis and gingival overgrowth. An important gene associated with Gingivitis is SOS1 (son of sevenless homolog 1 (Drosophila)), and among its related pathways are GPCR Pathway and Akt Signaling. The drug carbamide peroxide and the compounds retinoic acid and lactate have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and endothelial, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Gingivitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gingivitis 8 10 44 60
chronic gingivitis 8 44 60
acute gingivitis 8 60
chronic gingivitis nos 8
gingivitis nos 8


Related Diseases for Gingivitis

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17GeneCards, 18GeneDecks
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Diseases related to Gingivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 423)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.6MMP8, IL1B, IL1A
2gingival overgrowth31.6FGF7, MMP1
3gingival recession31.6DSPP
4periodontal disease31.1ELANE, GUSB, MMP3, MMP1, TIMP1
5aggressive periodontitis30.8MMP1, MMP8, IL1A
6leukemia30.5GUSB, FGF7, IL1A, TGFB1, IL1B
7fibromatosis, gingival30.4TGFB1, MMP1, CD36, SOS1
8rheumatoid arthritis30.4TIMP1, IL1B, IL1A, FGF7, ELANE, GUSB
9arthritis30.4CTSB, TGFB1, MMP1, MMP8, MMP3, IL1B
10squamous cell carcinoma30.4FGF7, TIMP1, CTSB, MMP3, TGFB1, MMP1
11acute leukemia30.3LPO
12diabetes mellitus30.3TGFB1, CD36, MMP3, IL1B
13dental caries30.2LPO, MMP8, DSPP
14sarcoma30.2GUSB, FGF7
15down syndrome30.1DSPP
16cleft palate30.1DSPP
17systemic scleroderma30.0MMP1, TIMP1, CD36, IL1A, MMP3, TGFB1
18osteoporosis30.0CD36, MMP8, TGFB1, MMP3
19obesity30.0MMP3
20pneumonia29.8TGFB1, IL1B, FGF7, CTSB, MMP8, ELANE
21adenocarcinoma29.8FGF7, TGFB1, TIMP1, CTSB, GUSB
22pulpitis29.8DSPP, IL1A, TIMP1, MMP1
23hepatocellular carcinoma29.8TIMP1, ELANE, TGFB1
24oral submucous fibrosis29.8TIMP1, MMP1
25sarcoidosis29.8IL1B, IL1A
26cerebral palsy29.8MMP8
27atherosclerosis29.6IL1A, IL1B, MMP3, MMP8, MMP1, ELANE
28inflammatory bowel disease29.6GUSB, FGF7, IL1B, MMP1, ELANE, MMP3
29colorectal cancer29.6FGF7, GUSB, TGFB1, CTSB, MMP1, TIMP1
30osteosarcoma29.6TGFB1, TIMP1, IL1A, CTSB, MMP1, CD36
31lung cancer29.6FGF7, MMP8, TIMP1, CTSB, GUSB, DSPP
32multiple sclerosis29.6TGFB1, IL1B, TIMP1, MMP8
33arthropathy29.6MMP3, IL1B, TIMP1, MMP1
34myeloma29.6MMP8, IL1B, CD36
35myeloid leukemia29.6TGFB1, ELANE
36neutropenia29.6ELANE
37lung giant cell carcinoma29.6TGFB1, TIMP1
38localized scleroderma29.6MMP1, CD36
39familial mediterranean fever29.6IL1B
40fabry disease29.6GUSB
41amyloidosis29.6CTSB
42gingival disease10.8
43necrotizing ulcerative gingivitis10.8
44gingival hypertrophy10.5
45hypertrichosis10.4
46lichen planus10.3
47gingival fibromatosis with hypertrichosis10.3
48granular cell tumor10.3
49congenital granular cell tumor10.3
50epulis10.3

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to gingivitis

Clinical Features for Gingivitis

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Drugs & Therapeutics for Gingivitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gingivitis

Drug clinical trials:

Search ClinicalTrials for Gingivitis

Search NIH Clinical Center for Gingivitis

Search CenterWatch for Gingivitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gingivitis

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Anatomical Context for Gingivitis

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32MalaCards
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MalaCards organs/tissues related to Gingivitis:

32
Bone, Monocytes, Endothelial, Heart, T cells, Testes, Tongue, Kidney, Myeloid, Salivary gland, Liver, Lung, Skin, Colon, B cells, Testis, Prostate, Ovary, Breast, Thyroid, Smooth muscle, Brain, Whole blood, Bone marrow

Animal Models for Gingivitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gingivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8TGFB1, TIMP1, SOS1, CTSB, CD36, FGF7
2MP:000537611.2ELANE, FGF7, CD36, GUSB, CTSB, SOS1
3MP:000200610.9TIMP1, CTSB, IL1B, MMP8, ELANE, TGFB1

Publications for Gingivitis

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50PubMed
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Articles related to Gingivitis:

(show top 50)    (show all 2679)
idTitleAuthorsYear
1
Gingival myeloid sarcoma in myelodysplastic syndrome. (23288397)
2013
2
Expression of angiotensin II and its receptors in cyclosporine-induced gingival overgrowth. (23106187)
2013
3
Gingival squamous cell carcinoma masquerading as an aphthous ulcer. (24174737)
2013
4
Effect of periodontal therapy on the course of cyclosporin-induced gingival overgrowth: role of ABCB1 and PAI-1 gene polymorphisms. (23444206)
2013
5
Comparison of two power interdental cleaning devices on the reduction of gingivitis. (22435321)
2012
6
Is gingival recession a consequence of an orthodontic tooth size and/or tooth position discrepancy? "A paradigm shift". (23738895)
2011
7
Preliminary characterization of the oral microbiota of Chinese adults with and without gingivitis. (22152152)
2011
8
Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study. (21584253)
2011
9
Letter to the editor: re: "treatment of multiple areas of gingival recession using a simple harvesting technique for autogenous connective tissue graft". (20225939)
2010
10
Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism. (19473524)
2009
11
Cytokines differentially regulate CXCL10 production by interferon-gamma-stimulated or tumor necrosis factor-alpha-stimulated human gingival fibroblasts. (18973545)
2009
12
Clinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosis. (18061489)
2008
13
Double laterally rotated bilayer flap operation for treatment of gingival recession: A report of two cases. (20142945)
2008
14
Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells. (18565136)
2008
15
Effect of three different dental health preventive programmes on young adult individuals: a randomized, blinded, parallel group, controlled evaluation of oral hygiene behaviour on plaque and gingivitis. (17448044)
2007
16
Juvenile spongiotic gingivitis. (17608578)
2007
17
Effectiveness of a triclosan/copolymer dentifrice on dental plaque and gingivitis in Brazilian individuals with cerebral palsy. (17972445)
2007
18
A review of the effects of stannous fluoride on gingivitis. (16367849)
2006
19
Gingival recession treatment with connective tissue grafts in smokers and non-smokers. (16805676)
2006
20
Enhancement of nifedipine-induced gingival overgrowth by concomitant ketoconazole in rats. (15677883)
2005
21
New oral rinse helps treat gingivitis. (16255070)
2005
22
Treatment of gingival recession using a collagen membrane with or without the use of demineralized freeze-dried bone allograft for space maintenance. (15068108)
2004
23
Streptococcal gingivitis: a report of case with a description of a unique gingival prosthesis. (15318266)
2004
24
Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma. (15319251)
2004
25
Human gingival mucosal keratinocytes exhibiting anchorage-independent growth express increased inducible nitric oxide synthase: regulation by MAP kinases. (15566970)
2004
26
A clinical comparison of the gingivitis reduction and plaque-removal efficacy of a new manual toothbrush. (15789981)
2004
27
Double laterally-rotated bilayer flap operation for treatment of gingival recession. (15318281)
2004
28
Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. (12828653)
2003
29
Gingival disease associated with a decorative crown. (11874059)
2002
30
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice. (12466121)
2002
31
Binary regulation of interleukin (IL)-6 production by EP1 and EP2/EP4 subtypes of PGE2 receptors in IL-1beta-stimulated human gingival fibroblasts. (11842936)
2002
32
Gingival crevicular fluid matrix metalloproteinase-8 levels following adjunctive use of meloxicam and initial phase of periodontal therapy. (11846190)
2002
33
Treatment of gingival recession with collagen membranes. (12004684)
2001
34
Microassay for the detection of elastase activity in the gingival crevice. (11142664)
2001
35
Chronic gingival erythema and tenderness. Foreign body gingivitis. (12024744)
2001
36
Effects of a chewable sodium bicarbonate oral composition on plaque and gingivitis. (12167942)
2001
37
Evaluation of osteocalcin and pyridinium crosslinks of bone collagen as markers of bone turnover in gingival crevicular fluid during different stages of orthodontic treatment. (9667483)
1998
38
Role of medullasin in nifedipine-induced gingival overgrowth in rats. (9796781)
1998
39
Hyporesponsiveness of inflamed human gingival fibroblasts from patients with chronic periodontal diseases against cell surface components of Porphyromonas gingivalis. (9215583)
1997
40
Dose-dependent gingival overgrowth induced by cyclosporin in rats. (7562351)
1995
41
Serum fructosamine correlates with gingival index in children with insulin-dependent diabetes mellitus (IDDM). (7989622)
1994
42
Increased interleukin-1 beta levels in gingival crevicular fluid of Chinese periodontal patients. (7912593)
1994
43
Hypertrichosis universalis congenita: a separate entity, or the same disease as gingival fibromatosis? (8415305)
1993
44
Prostaglandin E2 antagonizes gingival fibroblast proliferation stimulated by interleukin-1 beta. (8302918)
1993
45
Inhibition of elastase activity in human gingival extracts by elastin peptides]. (1296160)
1992
46
Five parameters of gingival crevicular fluid from eight surfaces in periodontal health and disease. (1328590)
1992
47
Characterization of human gingival keratinocytes cultured in a serum-free medium. (2076062)
1990
48
Gingival overgrowth: hereditary considerations. (2097045)
1990
49
An analysis of localized gingival recession in 766 Winnipeg High School students. (5218030)
1966
50
DISEASES OF THE MOUTH; DIFFERENTIAL DIAGNOSIS. II. GINGIVITIS, STOMATITIS, GINGIVOSTOMATITIS AND CHEILITIS. (14133077)
1964

Genetic Variations for Gingivitis

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Expression for genes affiliated with Gingivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gingivitis

Search GEO for disease gene expression data for Gingivitis.

Pathways for genes affiliated with Gingivitis

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 52R&D Systems
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Pathways related to Gingivitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4TIMP1, SOS1, FGF7, MMP3, MMP8, MMP1
2
Hide members
11.2TIMP1, SOS1, FGF7, IL1A, IL1B, TGFB1
3
Hide members
11.2SOS1, CTSB, CD36, FGF7, IL1A, IL1B
4
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11.1SOS1, CD36, MMP3, MMP8, MMP1
5
Hide members
11.1SOS1, FGF7, IL1A, IL1B, TGFB1
6
Hide members
11.1MMP1, MMP8, MMP3, CTSB, TIMP1
7
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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11.0TIMP1, SOS1, MMP3, MMP1
8
Hide members
11.0MMP1, MMP8, MMP3, TIMP1
9
Cell adhesion ECM remodeling
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11.0TIMP1, MMP3, MMP8, MMP1
10
Hide members
11.0TIMP1, CTSB, MMP3, MMP8
1110.9TGFB1, IL1B, IL1A
1210.9CD36, IL1A, IL1B
1310.9CD36, MMP8, ELANE
14
Cell adhesion Cell-matrix glycoconjugates
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10.9MMP3, MMP1, ELANE
15
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10.9IL1B, IL1A, TIMP1
16
Immune response Bacterial infections in normal airways
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10.9IL1B, IL1A, CTSB
1710.7IL1B, IL1A
1810.7TGFB1, IL1B
19
Hide members
10.7TGFB1, ELANE
20
Hide members
10.7CD36, TIMP1
21
Hide members
10.7FGF7, TIMP1

Compounds for genes affiliated with Gingivitis

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB
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Compounds related to Gingivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.3IL1A, FGF7, IL1B, TGFB1, MMP8, CD36
2lactate4412.2MMP3, DSPP, LPO, GUSB, CTSB, TIMP1
3vegf4412.1IL1A, CTSB, CD36, TGFB1, IL1B, TIMP1
4cysteine4412.1FGF7, MMP3, CTSB, MMP8, ELANE, MMP1
5glycosaminoglycan4412.1TIMP1, GUSB, CD36, FGF7, IL1A, MMP3
6hyaluronic acid44 2413.1CD36, IL1B, TGFB1, ELANE, TIMP1, FGF7
7genistein44 28 59 2 11 2417.0CD36, MMP1, TIMP1, GUSB, FGF7, IL1A
8serine4412.0SOS1, TIMP1, TGFB1, MMP8, MMP1, CTSB
9glutamine4411.9MMP3, ELANE, TGFB1, IL1A, TIMP1, FGF7
10doxycycline44 1112.8MMP8, TIMP1, DSPP, FGF7, MMP3, ELANE
11heparin44 28 11 2414.8MMP3, GUSB, CTSB, TIMP1, IL1A, FGF7
12h2o24411.8CD36, MMP1, MMP8, FGF7, CTSB, LPO
13tgf beta14411.8TIMP1, FGF7, MMP1, TGFB1, MMP3, IL1B
14calcitriol44 59 11 2414.8IL1A, DSPP, TGFB1, MMP1, IL1B, CD36
15ribonucleic acid4411.7FGF7, IL1A, MMP1, MMP3, IL1B, TIMP1
16sb 20358044 5912.7TIMP1, CD36, IL1B, TGFB1, IL1A, MMP1
17alendronate44 49 1113.7DSPP, TIMP1, CD36, MMP3, MMP1, MMP8
18batimastat44 59 1113.7MMP1, TIMP1, CD36, MMP3, ELANE, MMP8
19tetracycline44 1112.6MMP8, TGFB1, MMP1, IL1A, DSPP, GUSB
20paraffin4411.6MMP3, DSPP, CD36, MMP1, CTSB, TGFB1
21cyclosporin a44 28 5913.5MMP8, ELANE, MMP1, CTSB, FGF7
22curcumin4411.5TIMP1, TGFB1, MMP1, MMP3, IL1B, IL1A
23vitamin d4411.5ELANE, DSPP, MMP3, FGF7, CD36
24aspirin44 49 28 2414.5TGFB1, TIMP1, GUSB, IL1B, MMP1, ELANE
25hydroxyproline44 11 2413.4MMP1, TGFB1, TIMP1, CTSB, CD36
26(4-aminophenyl)mercuric acetate4411.4ELANE, MMP8, MMP3, TIMP1
27uva 14411.4IL1A, MMP3, MMP1, TIMP1
28rantes4411.4TGFB1, IL1A, FGF7, IL1B
29matrigel4411.3CTSB, FGF7, MMP3, MMP1
30ascorbic acid44 2412.3MMP3, IL1A, MMP1, LPO, CD36, DSPP
31pirfenidone44 5912.3TGFB1, IL1B, IL1A, CD36
32dexamethasone44 49 28 1114.3TGFB1, DSPP, TIMP1
33clodronate44 49 1113.3MMP8, MMP1, CD36, IL1B
34creatinine4411.3TGFB1, CD36, MMP1, MMP3, IL1A, CTSB
35minocycline44 1112.3IL1B, TIMP1, DSPP, IL1A
3612-o-tetradecanoylphorbol 13-acetate4411.2MMP1, IL1A, FGF7, MMP3, TIMP1, TGFB1
37aprotinin44 1112.2ELANE, MMP1, TIMP1, CTSB
38nimesulide44 1112.2TIMP1, MMP3, MMP1
39hydroxamate4411.2MMP1, MMP8, TIMP1, MMP3
40alginate4411.2ELANE, CD36
41marimastat44 59 1113.2TIMP1, MMP8, MMP3, MMP1
42leflunomide49 44 1113.1MMP1, MMP3, IL1B, TIMP1
43hydrocortisone44 2 59 1114.1ELANE, MMP1
44pge24411.1TGFB1
45procollagen4411.0TGFB1
46cycloheximide4411.0FGF7
47rhein4411.0IL1B, TGFB1, TIMP1
48indomethacin44 59 28 1113.9CTSB
49troglitazone44 28 59 1113.9IL1B, MMP1, CD36
50ns 39844 5911.7IL1A, IL1B, MMP1, TGFB1

GO Terms for genes affiliated with Gingivitis

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16Gene Ontology
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Cellular components related to Gingivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.8TGFB1, TIMP1, FAM20A, CTSB, FGF7, IL1A
2extracellular spaceGO:00561511.4TGFB1, MMP8, MMP3, IL1B, IL1A, LPO
3proteinaceous extracellular matrixGO:00557810.8DSPP, MMP3, MMP8, MMP1, TGFB1

Biological processes related to Gingivitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.6TIMP1, CTSB, MMP3, MMP8, MMP1, ELANE
2extracellular matrix disassemblyGO:02261711.5ELANE, MMP1, MMP8, MMP3, CTSB, TIMP1
3collagen catabolic processGO:03057411.3CTSB, MMP3, MMP8, MMP1, ELANE
4positive regulation of cell divisionGO:05178111.2TGFB1, IL1B, IL1A, FGF7
5blood coagulationGO:00759611.2TIMP1, SOS1, CD36, MMP1, TGFB1
6proteolysisGO:00650811.1CTSB, MMP3, MMP8, MMP1, ELANE
7platelet activationGO:03016811.1TGFB1, CD36, SOS1, TIMP1
8positive regulation vascular endothelial growth factor productionGO:01057511.0IL1A, IL1B, TGFB1
9fever generationGO:00166010.9IL1B, IL1A
10platelet degranulationGO:00257610.8TGFB1, CD36, TIMP1
11positive regulation of interleukin-2 biosynthetic processGO:04508610.7IL1B, IL1A
12hyaluronan catabolic processGO:03021410.4TGFB1, GUSB

Products for genes affiliated with Gingivitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gingivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet