MCID: GNG013
MIFTS: 64

Gingivitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Gingivitis

Summaries for Gingivitis

MalaCards based summary : Gingivitis, also known as chronic gingivitis, is related to gingival disease and periodontitis, aggressive, 1, and has symptoms including denture irritation, tenderness of gums and signs and symptoms, digestive. An important gene associated with Gingivitis is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Chlorhexidine and Hexetidine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Gingivitis is a non-destructive disease that occurs around the teeth. The most common form of... more...

Related Diseases for Gingivitis

Diseases related to Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 570)
# Related Disease Score Top Affiliating Genes
1 gingival disease 32.8 CD79A ELANE IL1B IL6 MMP8
2 periodontitis, aggressive, 1 32.2 IL1A LTF MMP8
3 periapical periodontitis 31.7 IL1B MMP8 MMP9
4 orofacial granulomatosis 31.2 CD79A IL4 TNF
5 periodontitis, chronic 30.6 IL1B IL6 MMP8
6 periodontosis 30.5 CD79A CXCL8 ELANE MMP9
7 aggressive periodontitis 30.5 CXCL8 IL1A IL1B IL4 IL6 MMP8
8 lichen planus 30.3 DEFB4A IL4 TNF
9 periodontitis 30.3 CXCL8 ELANE IL1A IL1B IL4 IL6
10 cytomegalovirus infection 30.1 CXCL8 IL6 TNF
11 esophagitis 30.1 CXCL8 IL1B IL6
12 cerebral palsy 30.0 IL1B IL6 TNF
13 conjunctivitis 30.0 CXCL8 IL4 IL6
14 vaginitis 29.9 CXCL8 IL1B IL6
15 laryngitis 29.9 IL1B IL6 TNF
16 pulpitis 29.9 CXCL8 IL1B IL6 TNF
17 monocytic leukemia 29.9 CXCL8 IL1B IL6 TNF
18 dengue hemorrhagic fever 29.8 CXCL8 IL6 TNF
19 juvenile rheumatoid arthritis 29.8 IL1B IL6 TNF
20 arthritis 29.8 CXCL8 IL1A IL1B IL6 MMP9 TNF
21 paracoccidioidomycosis 29.7 IL4 IL6 TNF
22 prostatitis 29.7 CXCL8 IL1B IL6 TNF
23 leptospirosis 29.7 CXCL8 IL1B IL6 TNF
24 peritonitis 29.6 CXCL8 IL1B IL6 TNF
25 synovitis 29.6 CXCL8 IL1B IL6 TNF
26 graft-versus-host disease 29.6 IL1A IL1B IL6 TNF
27 periodontal disease 29.6 CD79A CXCL8 DEFB4A ELANE GUSB IL1A
28 acquired immunodeficiency syndrome 29.6 CD79A IL1B IL6 TNF
29 pneumonia 29.4 CXCL8 ELANE IL1B IL6 TNF
30 end stage renal failure 29.4 CD79A IL6 TNF
31 osteomyelitis 29.4 CXCL8 IL1A IL1B IL6 TNF
32 aphthous stomatitis 29.4 IL1B IL4 IL6 TNF
33 brucellosis 29.3 CXCL8 IL4 IL6 TNF
34 chlamydia 29.3 CD79A CXCL8 IL1B IL6 TNF
35 myeloma, multiple 29.3 CD79A CXCL8 IL6
36 arteries, anomalies of 29.2 IL1B IL6 MMP9 PLAT TNF
37 rheumatoid arthritis 29.0 CD79A CXCL8 IL1A IL1B IL4 IL6
38 wegener granulomatosis 28.9 CTSG CXCL8 ELANE IL6 TNF
39 multiple sclerosis 28.9 IL1B IL4 IL6 MMP9 TNF
40 tonsillitis 28.2 CD79A CXCL8 IL1A IL1B IL4 IL6
41 bone inflammation disease 28.2 CD79A CXCL8 IL1A IL1B IL4 IL6
42 systemic lupus erythematosus 27.4 CD79A CTSG ELANE IL1B IL4 IL6
43 inflammatory bowel disease 26.0 CD79A CTSG CXCL8 DEFB4A ELANE IL1A
44 gingival recession 12.5
45 gingival overgrowth 12.5
46 gingival fibromatosis 12.4
47 fibromatosis, gingival, 1 12.4
48 necrotizing ulcerative gingivitis 12.4
49 hypertrichosis, congenital generalized, with or without gingival hyperplasia 12.4
50 fibromatosis, gingival, 2 12.3

Comorbidity relations with Gingivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to Gingivitis

Symptoms & Phenotypes for Gingivitis

UMLS symptoms related to Gingivitis:


denture irritation, tenderness of gums, signs and symptoms, digestive

MGI Mouse Phenotypes related to Gingivitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 SERPINB2 IL4 TNF IL6 CD79A CTSG
2 homeostasis/metabolism MP:0005376 10.07 TNF IL1B SERPINB2 IL4 IL6 CD79A
3 immune system MP:0005387 9.97 SERPINB2 IL4 TNF IL6 CD79A CTSG
4 integument MP:0010771 9.56 TNF IL1B IL4 IL6 GUSB MMP9
5 neoplasm MP:0002006 9.36 TNF IL6 CD79A CTSG LTF ELANE

Drugs & Therapeutics for Gingivitis

Drugs for Gingivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 174)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 55-56-1 2713 9552079
2
Hexetidine Approved, Investigational Phase 4 141-94-6
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4 sodium fluoride Approved Phase 4,Phase 3,Phase 1,Phase 2 7681-49-4
5
Tea tree oil Approved Phase 4
6
Triclosan Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 3380-34-5 5564
7
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
8 Cetylpyridinium Approved Phase 4,Phase 3,Phase 2,Phase 1 7773-52-6
9
Menthol Approved Phase 4 2216-51-5 16666
10
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
11
Thymol Approved Phase 4 89-83-8 6989
12
Zinc Approved, Investigational Phase 4,Phase 2 7440-66-6 32051 23994
13
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 54670067 5785
14
Eucalyptol Approved, Nutraceutical Phase 4 470-82-6 2758
15 Antifungal Agents Phase 4
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Cariostatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2
20 Dermatologic Agents Phase 4,Phase 3,Phase 2
21 Disinfectants Phase 4,Phase 3,Phase 2
22 Fluorides Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
23 Listerine Phase 4,Phase 3,Phase 1,Phase 2
24 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Anesthetics Phase 4
27 Vitamins Phase 4,Phase 3,Phase 2,Early Phase 1
28 Antimetabolites Phase 4,Phase 3,Phase 2
29 Hypolipidemic Agents Phase 4,Phase 3,Phase 2
30 Lipid Regulating Agents Phase 4,Phase 3,Phase 2
31 Calcium, Dietary Phase 4
32 Caseins Phase 4
33 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1,Early Phase 1
34 Central Nervous System Depressants Phase 4
35 Antioxidants Phase 4,Phase 3
36 Antiparasitic Agents Phase 4,Phase 3
37 Antiprotozoal Agents Phase 4,Phase 3
38
Tin Phase 4,Phase 3 7440-31-5
39 Tin Fluorides Phase 4,Phase 3
40 Fluorophosphate Phase 4
41 Chelating Agents Phase 4
42 Salicylates Phase 4
43 Acidophilus Nutraceutical Phase 4,Phase 3,Phase 2
44 Tea Tree Nutraceutical Phase 4
45 Anthocyanidin Nutraceutical Phase 4
46 Proanthocyanidin Nutraceutical Phase 4
47
Procyanidin Nutraceutical Phase 4 4852-22-6 147299
48
Catechin Nutraceutical Phase 4 154-23-4 9064
49
Epicatechin Investigational, Nutraceutical Phase 4 490-46-0 72276
50
Aminocaproic Acid Approved, Investigational Phase 3 60-32-2 564

Interventional clinical trials:

(show top 50) (show all 251)

# Name Status NCT ID Phase Drugs
1 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
2 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
3 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
4 Effect of Different Mouthrinses in Plaque Formation Unknown status NCT02695901 Phase 4 Chlorhexidine gluconate 0.12% (PerioGard®);Nanoparticle solution of M. alternifolia oil (0.3%).
5 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
6 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
7 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
8 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
9 Essential Oil+ELA, Plaque and Gingivitis Completed NCT02884817 Phase 4 Experimental: essential oils and ELA
10 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
11 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed NCT02080273 Phase 4 Colgate Cavitity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
12 Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables Completed NCT01578603 Phase 4
13 Evaluate Inflammation Caused by Gingivitis in Adults Completed NCT00941668 Phase 4 Triclosan/Copolymer/fluoride toothpaste;sodium monofluorophosphate toothpaste
14 A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease Completed NCT02065414 Phase 4
15 Effect of Mouthrinsing on Inflammation of the Gums. Completed NCT01317446 Phase 4 amine fluoride/stannous fluoride
16 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
17 Compare Anti-inflammatory Dentifrices Completed NCT00762528 Phase 4 Triclosan/Copolymer/fluoride toothpaste;Sodium monofluorophosphate toothpaste
18 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
19 "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. Completed NCT02154594 Phase 4 Acacia catechu;Chlorhexidine gluconate
20 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
21 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
22 Clinical Examination of Metal Free Interdental Brushes Completed NCT01593540 Phase 4
23 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
24 Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study Completed NCT01213550 Phase 4 Chlorhexidine gluconate;Placebo mouthrinse
25 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. Completed NCT02124655 Phase 4 Essential oils;0.2% chlorhexidine;Sterile water
26 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
27 Interaction Between Chlorhexidine and Fluoride Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
28 Periodontal Treatment Response in Type II Diabetic Patients Completed NCT01881074 Phase 4 Triclosan containing toothpaste;Non-triclosan containing toothpaste
29 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis Recruiting NCT03219840 Phase 4 CPC;Placebo
30 Impact of Oral Hygiene Gels on Peri-implant Mucositis Recruiting NCT03243591 Phase 4
31 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Recruiting NCT02030470 Phase 4
32 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Active, not recruiting NCT03099551 Phase 4
33 Treatment of Peri-implantitis Lesions by Using Biomaterial Active, not recruiting NCT02375750 Phase 4
34 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
35 Efficacy of Different Chlorhexidine Concentrations Not yet recruiting NCT02911766 Phase 4 Chlorhexidine 0.2% Mouthrinse;Chlorhexidine 0.12% mouthrinse;Chlorhexidine 0.06% mouthrinse
36 Evaluation and Comparison of Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Mouth Rinse Not yet recruiting NCT02987634 Phase 4
37 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth Not yet recruiting NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
38 Efficacy of a Mouthwash Containing Propolis Unknown status NCT01750801 Phase 3 Propolis;chlorhexidine
39 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis Completed NCT00926328 Phase 3 Triclosan, fluoride;Fluoride
40 Effects of Antioxidant Dentifrice on Gingivitis Completed NCT02102295 Phase 3 Experimental toothpaste;Control toothpaste
41 The Effect of Mouthrinses Containing Bamboo Salt, Magnolia Bark and Centella Asiatica on Reducing Plaque and Gingivitis Completed NCT03047798 Phase 3 Mouthrinse
42 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis Completed NCT02193165 Phase 3 triclosan/fluoride toothpaste + cetylpyridinium chloride Mouthwash;stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash;fluoride toothpaste + fluoride Mouthwash
43 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00964860 Phase 3
44 The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis Completed NCT02616042 Phase 3
45 Flossing With Chlorhexidine Completed NCT00471783 Phase 3
46 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes Completed NCT00762515 Phase 3 Fluoride;Triclosan;Fluoride
47 Effectiveness of Black Tea Mouthwash on Plaque Formation Completed NCT02545244 Phase 3 0.12% Chlorhexidine Mouthwash.
48 Effect of Probiotic Lozenge on Gingivitis and Periodontitis Completed NCT02203812 Phase 3 Probiotic Arm;Placebo Arm
49 Comparing the Inter-dental Brush to Dental Floss Completed NCT00743548 Phase 3
50 Development of Inflammatory Disease Model Protein, Genetic and Microbial Biomarkers Completed NCT00980525 Phase 2, Phase 3

Search NIH Clinical Center for Gingivitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: gingivitis

Genetic Tests for Gingivitis

Genetic tests related to Gingivitis:

# Genetic test Affiliating Genes
1 Gingivitis 28

Anatomical Context for Gingivitis

MalaCards organs/tissues related to Gingivitis:

38
Bone, Testes, Monocytes, Endothelial, Neutrophil, Heart, Kidney

Publications for Gingivitis

Articles related to Gingivitis:

(show top 50) (show all 3236)
# Title Authors Year
1
Molecular basis for immunohistochemical and inflammatory changes during progression of gingivitis to periodontitis. ( 29194785 )
2018
2
Adjunct Use of Low-Level Laser Therapy on the Treatment of Necrotizing Ulcerative Gingivitis: A Case Report. ( 29399316 )
2018
3
Treatment of gingival recession in 2 surgical stages: free gingival graft plus coronally positioned flap. ( 29303764 )
2018
4
Reversal of drug-induced gingival overgrowth by UV-mediated apoptosis of gingival fibroblasts - an in vitro study. ( 29427738 )
2018
5
Sub-epithelial connective tissue graft for the management of Miller's class I and class II isolated gingival recession defect: A systematic review of the factors influencing the outcome. ( 29424485 )
2018
6
Expression of CD163 in hereditary gingival fibromatosis: A possible association with TGF-I^1. ( 29325232 )
2018
7
The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study. ( 29321067 )
2018
8
High-power diode laser on management of drug-induced gingival overgrowth: Report of two cases and long-term follow-up. ( 29351498 )
2018
9
Quantitative measures of gingival recession and the influence of gender, race, and attrition. ( 29376198 )
2018
10
Effectiveness of two different herbal toothpaste formulations in the reduction of plaque and gingival inflammation in patients with established gingivitis - A randomized controlled trial. ( 29321998 )
2018
11
Impact of gingivitis treatment for diabetic patients on quality of life related to periodontal objective parameters: A randomized controlled clinical trial. ( 29197785 )
2018
12
Effect of scaling and root planing on gingival crevicular fluid cytokine/chemokine levels in smokers with chronic periodontitis: A systematic review. ( 29450974 )
2018
13
Effectiveness of laser adjunctive therapy for surgical treatment of gingival recession with flap graft techniques: a systematic review and meta-analysis. ( 29374364 )
2018
14
Gene expression profiling and bioinformatics analysis of hereditary gingival fibromatosis. ( 29435271 )
2018
15
Prevalence of gingivitis and calculus in 12-year-old Puerto Ricans: a cross-sectional study. ( 29351752 )
2018
16
Necrotizing fungal gingivitis in a patient with Acute Myelogenous Leukemia: visible yet obscure. ( 29404266 )
2018
17
Xenogenic collagen matrix or autologous connective tissue graft as adjunct to coronally advanced flaps for coverage of multiple adjacent gingival recession: Randomized trial assessing non-inferiority in root coverage and superiority in oral health-related quality of life. ( 29087001 )
2018
18
Definitive abutments probably result in minimal decrease in bone loss and buccal gingival recession compared with traditional implants. ( 29150019 )
2018
19
Topical application of glycyrrhetinic acid in the gingival sulcus inhibits attachment loss in lipopolysaccharide-induced experimental periodontitis in rats. ( 29446076 )
2018
20
Antioxidants and NOX1/NOX4 inhibition blocks TGFI^1-induced CCN2 and I+-SMA expression in dermal and gingival fibroblasts. ( 29049376 )
2017
21
Platelet-rich fibrin membrane does not improve clinical outcomes compared with otherA treatment modalities in the treatment of gingival recession. ( 28550846 )
2017
22
Gingival fibromatosis with hypertrichosis syndrome: Case series of rare syndrome. ( 28836540 )
2017
23
Connective Tissue Graft and Crown-Resin Composite Restoration for the Treatment of Gingival Recession Associated with Noncarious Cervical Lesions: Case Series. ( 28609509 )
2017
24
Treatment of Plaque-induced Gingivitis, Chronic Periodontitis, and Other Clinical Conditions. ( 29179388 )
2017
25
Assessment of Vitamin B12 and Its Correlation with Dental Caries and Gingival Diseases in 10- to 14-year-old Children: A Cross-sectional Study. ( 28890613 )
2017
26
Two cases of granulomatosis polyangiitis presenting with Strawberry gingivitis and a review of the literature. ( 28689619 )
2017
27
The use of hyaluronic acid as an adjuvant in the management of gingivitis. ( 29202569 )
2017
28
Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts. ( 28641076 )
2017
29
Cytology and molecular mechanisms of drug-induced gingival hypertrophy: a rewiew. ( 29285323 )
2017
30
Histologic and Clinical Study of Gingival Recession Treated with Subepithelial Connective Tissue Graft: A Case Report. ( 27977823 )
2017
31
Clinical and microbiological effects of the adjunctive use of probiotics in the treatment of gingivitis: A randomized controlled clinical trial. ( 28556062 )
2017
32
Gingival recession and root caries in the ageing population: a critical evaluation of treatments. ( 28266119 )
2017
33
Gingival overgrowth: Part 2: management strategies. ( 28184072 )
2017
34
Development of a self-report questionnaire designed for population-based surveillance of gingivitis in adolescents: assessment of content validity and reliability. ( 28877279 )
2017
35
Comparative Evaluation of Platelet Rich Fibrin and Dehydrated Amniotic Membrane for the Treatment of Gingival Recession- A Clinical Study. ( 28969268 )
2017
36
Epulis-Like Presentation of Gingival Renal Cancer Metastasis. ( 28878662 )
2017
37
Distribution of dental plaque and gingivitis within the dental arches. ( 28795618 )
2017
38
Assessment of the Effects of a Novel Stabilized Stannous Fluoride Dentifrice on Gingivitis in a Two-Month Positive-Controlled Clinical Study. ( 29334436 )
2017
39
Tackle gingival recession head on. ( 28684804 )
2017
40
Gingival bleeding in a patient with autism spectrum disorder: A key finding leading to a diagnosis of scurvy. ( 28396889 )
2017
41
Congenital Gingival Granular Cell Tumor: A Case Report. ( 28293667 )
2017
42
Lack of Association Between TGF-I^1 and MDR1 Genetic Polymorphisms and Cyclosporine-Induced Gingival Overgrowth in Kidney Transplant Recipients: A Meta-analysis. ( 28736004 )
2017
43
Hereditary gingival fibromatosis: Characteristics and treatment approach. ( 28469831 )
2017
44
REST Final-Exon-Truncating Mutations Cause Hereditary Gingival Fibromatosis. ( 28686854 )
2017
45
Early diagnosis of an isolated primary peripheral T-cell lymphoma masquerading as massive gingival enlargement in a pediatric patient. ( 29391718 )
2017
46
Comparing the effect of 0.06% -, 0.12% and 0.2% Chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: a parallel group, double masked randomized clinical trial. ( 28821290 )
2017
47
Epithelial to mesenchymal transition in Cyclosporine A-induced rat gingival overgrowth. ( 28472720 )
2017
48
Transcriptome of Healthy Gingival Tissue from Edentulous Sites in Patients with a History of Aggressive Periodontitis. ( 28844188 )
2017
49
Development of chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis. ( 28832260 )
2017
50
Caveolin-1 serves as a negative effector in senescent human gingival fibroblasts during Fusobacterium nucleatum infection. ( 27315395 )
2017

Variations for Gingivitis

Expression for Gingivitis

Search GEO for disease gene expression data for Gingivitis.

Pathways for Gingivitis

Pathways related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 CD79A CTSG CXCL8 DEFB4A ELANE GUSB
2
Show member pathways
13.36 CXCL8 IL1A IL1B IL4 IL6 MMP9
3
Show member pathways
12.88 CXCL8 IL1A IL1B IL4 IL6 TNF
4
Show member pathways
12.83 CXCL8 IL1A IL1B IL4 IL6 TNF
5
Show member pathways
12.63 IL1A IL1B IL4 IL6 TNF
6 12.55 CD79A IL1B IL4 TNF
7
Show member pathways
12.52 CXCL8 IL1B IL6 TNF
8
Show member pathways
12.47 IL1A IL1B IL4 IL6 TNF
9
Show member pathways
12.38 CTSG DEFB4A ELANE LTF
10
Show member pathways
12.38 IL1B IL4 IL6 PLAT TNF
11
Show member pathways
12.33 CXCL8 IL1A IL1B IL6 TNF
12 12.31 CXCL8 ELANE IL6 MMP9 PLAT
13
Show member pathways
12.28 CXCL8 IL1A IL6 TNF
14
Show member pathways
12.28 CXCL8 DEFB4A IL1B IL4 IL6 MMP9
15
Show member pathways
12.27 IL1A IL1B IL4 TNF
16 12.25 IL1A IL1B IL6 TNF
17 12.24 CXCL8 IL1A IL1B IL6 TNF
18
Show member pathways
12.19 CXCL8 DEFB4A IL1B IL4 IL6 TNF
19
Show member pathways
12.16 CXCL8 IL1A IL1B IL4 IL6 TNF
20 12.15 IL1A IL1B MMP9 PLAT TNF
21 12.04 CD79A IL4 IL6 TNF
22 12 IL1B IL6 MMP9 TNF
23 11.98 CXCL8 IL1A IL1B IL6 TNF
24
Show member pathways
11.97 CTSG ELANE MMP8 MMP9 TNF
25 11.95 IL1A IL1B IL4 IL6 TNF
26 11.94 CTSG CXCL8 IL1B IL6 TNF
27 11.94 CXCL8 IL1A IL1B IL6 PLAT SERPINB2
28
Show member pathways
11.92 IL1B IL6 TNF
29 11.9 CXCL8 IL1A IL1B IL6 TNF
30 11.89 CXCL8 IL1A IL1B IL6
31 11.88 CXCL8 IL1B TNF
32
Show member pathways
11.86 IL1B IL4 IL6
33 11.81 CXCL8 IL4 IL6
34 11.8 IL1B IL4 TNF
35 11.8 CXCL8 IL1A IL1B IL6 TNF
36
Show member pathways
11.78 CXCL8 IL4 TNF
37 11.78 CXCL8 IL1A IL1B IL4 IL6 MMP9
38 11.76 IL1B IL6 TNF
39 11.71 IL4 IL6 TNF
40 11.7 CXCL8 IL6 MMP9
41 11.67 CXCL8 MMP9 PLAT
42 11.66 CXCL8 IL1B IL6 TNF
43 11.61 CXCL8 IL1B IL6 TNF
44 11.6 CXCL8 IL1B IL4 IL6 MMP9 TNF
45 11.56 IL1A IL1B IL6 TNF
46 11.56 CXCL8 IL1A IL1B IL4 IL6 MMP9
47 11.55 IL1B SERPINB2 TNF
48 11.55 IL1A IL1B IL6
49 11.54 ELANE IL6 MMP9 PLAT TNF
50
Show member pathways
11.53 CXCL8 IL1A IL1B IL6 MMP9 TNF

GO Terms for Gingivitis

Cellular components related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 CTSG CXCL8 DEFB4A ELANE GUSB IL1A
2 cell surface GO:0009986 9.77 CTSG ELANE LTF PLAT TNF
3 azurophil granule lumen GO:0035578 9.58 CTSG ELANE GUSB
4 secretory granule GO:0030141 9.55 CTSG ELANE IL1B LTF PLAT
5 specific granule lumen GO:0035580 9.5 ELANE LTF MMP8
6 extracellular space GO:0005615 9.5 CTSG CXCL8 DEFB4A ELANE GUSB IL1A
7 tertiary granule lumen GO:1904724 9.43 LTF MMP8 MMP9

Biological processes related to Gingivitis according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 CXCL8 IL1A IL1B IL6 TNF
2 leukocyte migration GO:0050900 9.93 ELANE IL1B MMP9 TNF
3 neutrophil degranulation GO:0043312 9.93 CTSG ELANE GUSB LTF MMP8 MMP9
4 regulation of receptor activity GO:0010469 9.91 CXCL8 IL1A IL1B IL4 IL6 TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.85 IL1B IL6 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 LTF TNF
7 cellular response to lipopolysaccharide GO:0071222 9.8 CTSG CXCL8 IL6 TNF
8 positive regulation of T cell proliferation GO:0042102 9.79 IL1B IL4 IL6
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 ELANE IL6 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.78 CTSG DEFB4A IL6 TNF
11 humoral immune response GO:0006959 9.77 IL6 LTF TNF
12 defense response to bacterium GO:0042742 9.77 CTSG DEFB4A ELANE LTF TNF
13 defense response to Gram-negative bacterium GO:0050829 9.71 CTSG DEFB4A IL6 LTF
14 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.69 IL1A IL1B TNF
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 IL1B TNF
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 IL1B TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.66 IL1B TNF
18 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.66 IL1A IL1B
19 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.65 IL1A IL1B
20 positive regulation of immune response GO:0050778 9.65 CTSG ELANE
21 negative regulation of lipid storage GO:0010888 9.64 IL6 TNF
22 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
23 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.63 ELANE TNF
24 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
25 ectopic germ cell programmed cell death GO:0035234 9.62 IL1A IL1B
26 extracellular matrix disassembly GO:0022617 9.62 CTSG ELANE MMP8 MMP9
27 fever generation GO:0001660 9.59 IL1A IL1B
28 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
29 sequestering of triglyceride GO:0030730 9.56 IL1B TNF
30 negative regulation of chemokine biosynthetic process GO:0045079 9.54 ELANE IL6
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 IL1B TNF
32 antimicrobial humoral response GO:0019730 9.46 CTSG DEFB4A ELANE LTF
33 negative regulation of growth of symbiont in host GO:0044130 9.43 CTSG ELANE TNF
34 positive regulation of interleukin-6 production GO:0032755 9.26 IL1A IL1B IL6 TNF
35 immune response GO:0006955 9.23 CTSG CXCL8 DEFB4A IL1A IL1B IL4
36 proteolysis GO:0006508 10.05 CTSG ELANE LTF MMP8 MMP9 PLAT
37 negative regulation of apoptotic process GO:0043066 10.04 IL4 IL6 LTF MMP9 SERPINB2

Molecular functions related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.87 CTSG ELANE GUSB LTF MMP8 MMP9
2 peptidase activity GO:0008233 9.63 CTSG ELANE LTF MMP8 MMP9 PLAT
3 serine-type peptidase activity GO:0008236 9.56 CTSG ELANE LTF PLAT
4 serine-type endopeptidase activity GO:0004252 9.43 CTSG ELANE LTF MMP8 MMP9 PLAT
5 cytokine activity GO:0005125 9.1 CXCL8 IL1A IL1B IL4 IL6 TNF

Sources for Gingivitis

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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