MCID: GNG013
MIFTS: 67

Gingivitis malady

Gastrointestinal diseases category

Summaries for Gingivitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gingivitis (\"inflammation of the gum tissue\") is a non-destructive periodontal disease. The most... more...

MalaCards: Gingivitis, also known as chronic gingivitis, is related to periodontitis and gingival overgrowth. An important gene associated with Gingivitis is SOS1 (son of sevenless homolog 1 (Drosophila)), and among its related pathways are GPCR Pathway and Akt Signaling. The drug carbamide peroxide and the compounds retinoic acid and lactate have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and endothelial, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Gingivitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

gingivitis 8 10 44 60
chronic gingivitis 8 44 60
acute gingivitis 8 60
chronic gingivitis nos 8
gingivitis nos 8


Related Diseases for Gingivitis

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17GeneCards, 18GeneDecks
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Diseases related to Gingivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 423)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.6MMP8, IL1B, IL1A
2gingival overgrowth31.6FGF7, MMP1
3gingival recession31.6DSPP
4periodontal disease31.1ELANE, GUSB, MMP3, MMP1, TIMP1
5aggressive periodontitis30.8MMP1, MMP8, IL1A
6leukemia30.5GUSB, FGF7, IL1A, TGFB1, IL1B
7fibromatosis, gingival30.4TGFB1, MMP1, CD36, SOS1
8rheumatoid arthritis30.4TIMP1, IL1B, IL1A, FGF7, ELANE, GUSB
9arthritis30.4CTSB, TGFB1, MMP1, MMP8, MMP3, IL1B
10squamous cell carcinoma30.4FGF7, TIMP1, CTSB, MMP3, TGFB1, MMP1
11acute leukemia30.3LPO
12diabetes mellitus30.3TGFB1, CD36, MMP3, IL1B
13dental caries30.2LPO, MMP8, DSPP
14sarcoma30.2GUSB, FGF7
15down syndrome30.1DSPP
16cleft palate30.1DSPP
17systemic scleroderma30.0MMP1, TIMP1, CD36, IL1A, MMP3, TGFB1
18osteoporosis30.0CD36, MMP8, TGFB1, MMP3
19obesity30.0MMP3
20pneumonia29.8TGFB1, IL1B, FGF7, CTSB, MMP8, ELANE
21adenocarcinoma29.8FGF7, TGFB1, TIMP1, CTSB, GUSB
22pulpitis29.8DSPP, IL1A, TIMP1, MMP1
23hepatocellular carcinoma29.8TIMP1, ELANE, TGFB1
24oral submucous fibrosis29.8TIMP1, MMP1
25sarcoidosis29.8IL1B, IL1A
26cerebral palsy29.8MMP8
27atherosclerosis29.6IL1A, IL1B, MMP3, MMP8, MMP1, ELANE
28inflammatory bowel disease29.6GUSB, FGF7, IL1B, MMP1, ELANE, MMP3
29colorectal cancer29.6FGF7, GUSB, TGFB1, CTSB, MMP1, TIMP1
30osteosarcoma29.6TGFB1, TIMP1, IL1A, CTSB, MMP1, CD36
31lung cancer29.6FGF7, MMP8, TIMP1, CTSB, GUSB, DSPP
32multiple sclerosis29.6TGFB1, IL1B, TIMP1, MMP8
33arthropathy29.6MMP3, IL1B, TIMP1, MMP1
34myeloma29.6MMP8, IL1B, CD36
35myeloid leukemia29.6TGFB1, ELANE
36neutropenia29.6ELANE
37lung giant cell carcinoma29.6TGFB1, TIMP1
38localized scleroderma29.6MMP1, CD36
39familial mediterranean fever29.6IL1B
40fabry disease29.6GUSB
41amyloidosis29.6CTSB
42gingival disease10.8
43necrotizing ulcerative gingivitis10.8
44gingival hypertrophy10.5
45hypertrichosis10.4
46lichen planus10.3
47gingival fibromatosis with hypertrichosis10.3
48granular cell tumor10.3
49congenital granular cell tumor10.3
50epulis10.3

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to gingivitis

Clinical Features for Gingivitis

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Drugs & Therapeutics for Gingivitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gingivitis

Drug clinical trials:

Search ClinicalTrials for Gingivitis

Search NIH Clinical Center for Gingivitis

Search CenterWatch for Gingivitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gingivitis

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Anatomical Context for Gingivitis

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32MalaCards
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MalaCards organs/tissues related to Gingivitis:

32
Bone, Monocytes, Endothelial, Heart, T cells, Testes, Tongue, Kidney, Myeloid, Salivary gland, Liver, Lung, Skin, Colon, B cells, Testis, Prostate, Ovary, Breast, Thyroid, Smooth muscle, Brain, Whole blood, Bone marrow

Animal Models for Gingivitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gingivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8TGFB1, TIMP1, SOS1, CTSB, CD36, FGF7
2MP:000537611.2ELANE, FGF7, CD36, GUSB, CTSB, SOS1
3MP:000200610.9TIMP1, CTSB, IL1B, MMP8, ELANE, TGFB1

Publications for Gingivitis

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50PubMed
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Articles related to Gingivitis:

(show top 50)    (show all 2679)
idTitleAuthorsYear
1
Impact of interleukin 1 gene polymorphism and smoking on long-term stability following gingival recession treatment. (23342354)
2013
2
Effect of periodontal therapy on serum C-reactive protein levels in patients with gingivitis and chronic periodontitis: a clinicobiochemical study. (23811651)
2013
3
Gingival recession and labial movement of lower incisors. (23579304)
2013
4
Response of pulp sensibility test is strongly influenced by periodontal attachment loss and gingival recession. (22515882)
2012
5
Giant gingival pseudoepitheliomatous hyperplasia in lung squamous cell carcinoma. (22801162)
2012
6
Extranodal non-Hodgkin's lymphoma presenting as gingival mass. (22368372)
2011
7
No difference between 0.12% and 0.2% chlorhexidine mouthrinse on reduction of gingivitis. (21436854)
2011
8
Classification of dental surface defects in areas of gingival recession. (20450362)
2010
9
Evaluation of the effectiveness of Er:YAG laser and conventional periodontal treatment in a patient with acute streptococcal gingivitis: a 2-year follow-up. (21142726)
2010
10
Relationship between gingival angiopoietin-1 concentrations and depth of the adjacent gingival sulcus. (19722795)
2009
11
Transglutaminase-2 regulation by arecoline in gingival fibroblasts. (19278990)
2009
12
Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factors. (19438976)
2009
13
Gingival overgrowth, congenital generalized hypertrichosis, mental retardation and epilepsy: case report and overview. (19625955)
2009
14
Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients. (19718004)
2009
15
Drop in transforming growth factor-alpha and osteoprotegerin level in gingival crevicular fluid from patients with gingivitis. (19591043)
2009
16
Gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy. (18269661)
2008
17
Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis. (18727658)
2008
18
The immunohistochemical analysis of vascular endothelial growth factors A and C and microvessel density in gingival tissues of systemic sclerosis patients: their possible effects on gingival inflammation. (18206400)
2008
19
Subepithelial connective tissue graft in the treatment of multiple gingival recession. (17618142)
2007
20
Apoptosis and expression of caspase-3 in cyclosporin-induced gingival overgrowth. (18052710)
2007
21
Opposite effects of TGF-beta1 and IFN-gamma on transdifferentiation of myofibroblast in human gingival cell cultures. (17403017)
2007
22
Identification of the osteoprotegerin/receptor activator of nuclear factor-kappa B ligand system in gingival crevicular fluid and tissue of patients with chronic periodontitis. (16827732)
2006
23
Gingival tissue and crevicular fluid co-operation in adult periodontitis. (16373682)
2006
24
Connective tissue metabolism and gingival overgrowth. (15187034)
2004
25
Necrotising ulcerative gingivitis/periodontitis as indicators of HIV-infection. (15214212)
2004
26
Aspartate aminotransferase activity in gingival crevicular fluid during orthodontic treatment. A controlled short-term longitudinal study. (12666701)
2003
27
Estimation of interleukin-1beta levels in the gingival crevicular fluid in health and in inflammatory periodontal disease. (12608903)
2003
28
Cytomegalovirus and cyclosporin-induced gingival overgrowth in children with liver grafts. (12121533)
2002
29
The benefits of toothpaste--real or imagined? The effectiveness of toothpaste in the control of plaque, gingivitis, periodontitis, calculus and oral malodour. (11819975)
2001
30
Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia. (10831096)
2000
31
In vitro stimulation of human gingival epithelial cell attachment to dentin by surface conditioning. (10397514)
1999
32
Prostaglandin F2 alpha upregulates intercellular adhesion molecule-1 expression in human gingival fibroblasts. (10567951)
1999
33
Increase of CD26/dipeptidyl peptidase IV expression on human gingival fibroblasts upon stimulation with cytokines and bacterial components. (10569731)
1999
34
Exostosis associated with autogenous gingival grafts: a report of 9 cases. (8794973)
1996
35
Juvenile systemic hyalinosis--a rare cause of gingival hypertrophy: a case report. (8695589)
1996
36
A comparison of cysteine and serine proteinases in human gingival crevicular fluid with tissue, saliva and bacterial enzymes by analytical isoelectric focusing. (8809301)
1996
37
Comparison of a sonic and a manual toothbrush for efficacy in supragingival plaque removal and reduction of gingivitis. (8841896)
1996
38
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects. (7722846)
1995
39
Periodontal management of nifedipine-induced gingival overgrowth: a case report and review of the pertinent literature. (8779668)
1994
40
Congenital marked hypertrichosis and Laband syndrome in a child: overlap between the gingival fibromatosis-hypertrichosis and Laband syndromes. (7811425)
1994
41
A cross-sectional study on osteocalcin levels in gingival crevicular fluid from periodontal patients. (8229623)
1993
42
Neutrophil elastase and its inhibitors in human gingival crevicular fluid during experimental gingivitis. (1372921)
1992
43
Creatine kinase and lactate dehydrogenase isoenzyme patterns in cultured normal and pathological gingival fibroblasts. (1973720)
1990
44
Within-mouth correlations for indicators of the host response in gingival crevicular fluid. (1702287)
1990
45
The role of gingival crevicular fluid and salivary interstitial collagenases in human periodontal diseases. (1965117)
1990
46
Cyclosporine and gingival overgrowth. (3123625)
1987
47
Acute necrotizing ulcerative gingivitis in a case of systemic lupus erythematosus. (3855317)
1985
48
Phenytoin-induced gingival overgrowth resulting in delayed eruption of the primary dentition. A case report. (6582260)
1984
49
Gingival recession in the mandibular central incisor region of Saudi schoolchildren aged 10-15 years. (6576884)
1983
50
Phenytoin-induced gingival overgrowth control in severely retarded children. (6956708)
1982

Genetic Variations for Gingivitis

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Expression for genes affiliated with Gingivitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gingivitis

Search GEO for disease gene expression data for Gingivitis.

Pathways for genes affiliated with Gingivitis

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Sources:
51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 52R&D Systems
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Pathways related to Gingivitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4TIMP1, SOS1, FGF7, MMP3, MMP8, MMP1
2
Hide members
11.2TIMP1, SOS1, FGF7, IL1A, IL1B, TGFB1
3
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11.2SOS1, CTSB, CD36, FGF7, IL1A, IL1B
4
Hide members
11.1SOS1, CD36, MMP3, MMP8, MMP1
5
Hide members
11.1SOS1, FGF7, IL1A, IL1B, TGFB1
6
Hide members
11.1MMP1, MMP8, MMP3, CTSB, TIMP1
7
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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11.0TIMP1, SOS1, MMP3, MMP1
8
Hide members
11.0MMP1, MMP8, MMP3, TIMP1
9
Cell adhesion ECM remodeling
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11.0TIMP1, MMP3, MMP8, MMP1
10
Hide members
11.0TIMP1, CTSB, MMP3, MMP8
1110.9TGFB1, IL1B, IL1A
1210.9CD36, IL1A, IL1B
1310.9CD36, MMP8, ELANE
14
Cell adhesion Cell-matrix glycoconjugates
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10.9MMP3, MMP1, ELANE
15
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10.9IL1B, IL1A, TIMP1
16
Immune response Bacterial infections in normal airways
Hide members
10.9IL1B, IL1A, CTSB
1710.7IL1B, IL1A
1810.7TGFB1, IL1B
19
Hide members
10.7TGFB1, ELANE
20
Hide members
10.7CD36, TIMP1
21
Hide members
10.7FGF7, TIMP1

Compounds for genes affiliated with Gingivitis

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB
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Compounds related to Gingivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.3IL1A, FGF7, IL1B, TGFB1, MMP8, CD36
2lactate4412.2MMP3, DSPP, LPO, GUSB, CTSB, TIMP1
3vegf4412.1IL1A, CTSB, CD36, TGFB1, IL1B, TIMP1
4cysteine4412.1FGF7, MMP3, CTSB, MMP8, ELANE, MMP1
5glycosaminoglycan4412.1TIMP1, GUSB, CD36, FGF7, IL1A, MMP3
6hyaluronic acid44 2413.1CD36, IL1B, TGFB1, ELANE, TIMP1, FGF7
7genistein44 28 59 2 11 2417.0CD36, MMP1, TIMP1, GUSB, FGF7, IL1A
8serine4412.0SOS1, TIMP1, TGFB1, MMP8, MMP1, CTSB
9glutamine4411.9MMP3, ELANE, TGFB1, IL1A, TIMP1, FGF7
10doxycycline44 1112.8MMP8, TIMP1, DSPP, FGF7, MMP3, ELANE
11heparin44 28 11 2414.8MMP3, GUSB, CTSB, TIMP1, IL1A, FGF7
12h2o24411.8CD36, MMP1, MMP8, FGF7, CTSB, LPO
13tgf beta14411.8TIMP1, FGF7, MMP1, TGFB1, MMP3, IL1B
14calcitriol44 59 11 2414.8IL1A, DSPP, TGFB1, MMP1, IL1B, CD36
15ribonucleic acid4411.7FGF7, IL1A, MMP1, MMP3, IL1B, TIMP1
16sb 20358044 5912.7TIMP1, CD36, IL1B, TGFB1, IL1A, MMP1
17alendronate44 49 1113.7DSPP, TIMP1, CD36, MMP3, MMP1, MMP8
18batimastat44 59 1113.7MMP1, TIMP1, CD36, MMP3, ELANE, MMP8
19tetracycline44 1112.6MMP8, TGFB1, MMP1, IL1A, DSPP, GUSB
20paraffin4411.6MMP3, DSPP, CD36, MMP1, CTSB, TGFB1
21cyclosporin a44 28 5913.5MMP8, ELANE, MMP1, CTSB, FGF7
22curcumin4411.5TIMP1, TGFB1, MMP1, MMP3, IL1B, IL1A
23vitamin d4411.5ELANE, DSPP, MMP3, FGF7, CD36
24aspirin44 49 28 2414.5TGFB1, TIMP1, GUSB, IL1B, MMP1, ELANE
25hydroxyproline44 11 2413.4MMP1, TGFB1, TIMP1, CTSB, CD36
26(4-aminophenyl)mercuric acetate4411.4ELANE, MMP8, MMP3, TIMP1
27uva 14411.4IL1A, MMP3, MMP1, TIMP1
28rantes4411.4TGFB1, IL1A, FGF7, IL1B
29matrigel4411.3CTSB, FGF7, MMP3, MMP1
30ascorbic acid44 2412.3MMP3, IL1A, MMP1, LPO, CD36, DSPP
31pirfenidone44 5912.3TGFB1, IL1B, IL1A, CD36
32dexamethasone44 49 28 1114.3TGFB1, DSPP, TIMP1
33clodronate44 49 1113.3MMP8, MMP1, CD36, IL1B
34creatinine4411.3TGFB1, CD36, MMP1, MMP3, IL1A, CTSB
35minocycline44 1112.3IL1B, TIMP1, DSPP, IL1A
3612-o-tetradecanoylphorbol 13-acetate4411.2MMP1, IL1A, FGF7, MMP3, TIMP1, TGFB1
37aprotinin44 1112.2ELANE, MMP1, TIMP1, CTSB
38nimesulide44 1112.2TIMP1, MMP3, MMP1
39hydroxamate4411.2MMP1, MMP8, TIMP1, MMP3
40alginate4411.2ELANE, CD36
41marimastat44 59 1113.2TIMP1, MMP8, MMP3, MMP1
42leflunomide49 44 1113.1MMP1, MMP3, IL1B, TIMP1
43hydrocortisone44 2 59 1114.1ELANE, MMP1
44pge24411.1TGFB1
45procollagen4411.0TGFB1
46cycloheximide4411.0FGF7
47rhein4411.0IL1B, TGFB1, TIMP1
48indomethacin44 59 28 1113.9CTSB
49troglitazone44 28 59 1113.9IL1B, MMP1, CD36
50ns 39844 5911.7IL1A, IL1B, MMP1, TGFB1

GO Terms for genes affiliated with Gingivitis

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16Gene Ontology
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Cellular components related to Gingivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.8TGFB1, TIMP1, FAM20A, CTSB, FGF7, IL1A
2extracellular spaceGO:00561511.4TGFB1, MMP8, MMP3, IL1B, IL1A, LPO
3proteinaceous extracellular matrixGO:00557810.8DSPP, MMP3, MMP8, MMP1, TGFB1

Biological processes related to Gingivitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.6TIMP1, CTSB, MMP3, MMP8, MMP1, ELANE
2extracellular matrix disassemblyGO:02261711.5ELANE, MMP1, MMP8, MMP3, CTSB, TIMP1
3collagen catabolic processGO:03057411.3CTSB, MMP3, MMP8, MMP1, ELANE
4positive regulation of cell divisionGO:05178111.2TGFB1, IL1B, IL1A, FGF7
5blood coagulationGO:00759611.2TIMP1, SOS1, CD36, MMP1, TGFB1
6proteolysisGO:00650811.1CTSB, MMP3, MMP8, MMP1, ELANE
7platelet activationGO:03016811.1TGFB1, CD36, SOS1, TIMP1
8positive regulation vascular endothelial growth factor productionGO:01057511.0IL1A, IL1B, TGFB1
9fever generationGO:00166010.9IL1B, IL1A
10platelet degranulationGO:00257610.8TGFB1, CD36, TIMP1
11positive regulation of interleukin-2 biosynthetic processGO:04508610.7IL1B, IL1A
12hyaluronan catabolic processGO:03021410.4TGFB1, GUSB

Products for genes affiliated with Gingivitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gingivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet