MCID: GNG013
MIFTS: 62

Gingivitis malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Gingivitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Gingivitis (\"inflammation of the gum tissue\") is a non-destructive periodontal disease. The most... more...

MalaCards: Gingivitis, also known as chronic gingivitis, is related to periodontitis and periodontal disease. An important gene associated with Gingivitis is GUSB (glucuronidase, beta), and among its related pathways are Selected targets of C EBPalpha and RNA Polymerase I Promoter Opening. The drug carbamide peroxide and the compounds 4-nitroanilide and elastatinal have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and endothelial, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Gingivitis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

gingivitis 9 11 46 63
chronic gingivitis 9 46 63
acute gingivitis 9 63
chronic gingivitis nos 9
gingivitis nos 9


Related Diseases for Gingivitis

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18GeneCards, 19GeneDecks
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Diseases related to Gingivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 383)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.8IL1A, MMP8
2periodontal disease31.2GUSB, ELANE
3aggressive periodontitis30.9IL1A, MMP8
4leukemia30.5GUSB, SERPINB2, IL1A, CTSG
5arthritis30.5IL1A, CTSG
6wegener's granulomatosis30.3CTSG, ELANE
7rheumatoid arthritis30.0GUSB, SERPINB2, MMP13, MMP8, ELANE, IL1A
8keloids30.0MMP13, MMP8
9pneumonia29.9CTSG, ELANE, MMP8
10chediak-higashi syndrome29.8CTSG, GUSB
11colorectal cancer29.7MMP13, SERPINB2, GUSB
12inflammatory bowel disease29.6GUSB, MMP13, ELANE, CTSG
13lung cancer29.5CST3, MMP8, MMP13, SERPINB2, GUSB
14atherosclerosis29.4SERPINB2, MMP13, MMP8, ELANE, IL1A, CST3
15gingival overgrowth11.1
16gingival recession11.1
17necrotizing ulcerative gingivitis10.8
18fibromatosis10.8
19gingival hypertrophy10.6
20gingival disease10.6
21hypertrichosis10.5
22blindness10.4
23endotheliitis10.4
24gingival fibromatosis with hypertrichosis10.4
25lichen planus10.4
26fibromatosis, gingival10.4
27granular cell tumor10.4
28epulis10.3
29oral lichen planus10.3
30vulvovaginal gingival syndrome10.3
31cervicitis10.3
32mental retardation10.3
33vulvovaginitis10.3
34mucous membrane pemphigoid10.3
35congenital epulis10.2
36amelogenesis imperfecta10.2
37cicatricial pemphigoid10.2
38diabetes mellitus10.2
39periostitis10.2
40stomatitis10.2
41gingival fibromatosis, 210.2
42gingival fibromatosis, 310.2
43gingival fibromatosis, 410.2
44laband syndrome10.2
45pemphigus10.2
46dental caries10.2
47sarcoma10.2
48gingival fibromatosis, 110.2
49jones syndrome10.2
50keratosis focal palmoplantar gingival10.2

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to gingivitis

Symptoms for Gingivitis

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Drugs & Therapeutics for Gingivitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Gingivitis

Drug clinical trials:

Search ClinicalTrials for Gingivitis

Search NIH Clinical Center for Gingivitis

Search CenterWatch for Gingivitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Gingivitis

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Anatomical Context for Gingivitis

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34MalaCards
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MalaCards organs/tissues related to Gingivitis:

34
Bone, Monocytes, Endothelial, Heart, T cells, Testes, Tongue, Kidney, Myeloid, Salivary gland, Liver, Lung, Skin, Colon, B cells, Testis, Prostate, Ovary, Breast, Thyroid, Smooth muscle, Brain, Whole blood, Bone marrow

Animal Models for Gingivitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Gingivitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1CTSG, IL1A, ELANE, MMP8, SERPINB2
2MP:00053977.9GUSB, SERPINB2, ELANE, IL1A, CTSG
3MP:00020067.7CTSG, CST3, IL1A, ELANE, MMP8
4MP:00053767.1GUSB, SERPINB2, MMP13, ELANE, IL1A, CST3

Publications for Gingivitis

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53PubMed
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Articles related to Gingivitis:

(show top 50)    (show all 2661)
idTitleAuthorsYear
1
Acute myelomonocytic leukemia presenting with gingival enlargement as the only clinical manifestation. (23493961)
2012
2
Plaque formation and marginal gingivitis associated with restorative materials. (23268568)
2012
3
Loss of basement membrane integrity in human gingival overgrowth. (21483030)
2011
4
Gingival overgrowth and drug association: a review. (23196317)
2011
5
Smad7 blocks transforming growth factor-I^1-induced gingival fibroblast-myofibroblast transition via inhibitory regulation of Smad2 and connective tissue growth factor. (21054221)
2011
6
A two-stage approach using an autogenous masticatory mucosal graft and an autogenous connective tissue graft to treat gingival recession: a case report. (20465031)
2010
7
Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans. (20096665)
2010
8
Gingival disease and secretory immunoglobulin a in non-stimulated saliva in children. (21462892)
2010
9
Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases]. (19594076)
2009
10
Prostaglandin E2 inhibits the proliferation of human gingival fibroblasts via the EP2 receptor and Epac. (19582788)
2009
11
Immortalization of normal human gingival keratinocytes and cytological and cytogenetic characterization of the cells. (19184294)
2009
12
Effect of transforming growth factor-beta1 on expression of the connective tissue growth factor (CCN2/CTGF) gene in normal human gingival fibroblasts and periodontal ligament cells. (19210343)
2009
13
Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo. (19186973)
2009
14
Clinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosis. (18061489)
2008
15
Gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy. (18269661)
2008
16
Raised chondroitin sulphate WF6 epitope levels in gingival crevicular fluid in chronic periodontitis. (18727658)
2008
17
Increased interleukin-18 in gingival crevicular fluid from periodontitis patients. (18279187)
2008
18
Subepithelial connective tissue graft in the treatment of multiple gingival recession. (17618142)
2007
19
Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate. (17199549)
2007
20
Pure choriocarcinoma of testis with rare gingival and skin metastases. (17342276)
2007
21
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. (16670920)
2006
22
Molecular changes in the gingival epithelium associated with necrotizing ulcerative periodontitis: a case report. (16642908)
2006
23
Profiling the cytokines in gingival crevicular fluid using a cytokine antibody array. (16671879)
2006
24
Clinical effect of a triclosan containing dentifrice on gingivitis during pregnancy and post-partum. (17121312)
2006
25
Current trends in gingival recession coverage--part I: the tunnel connective tissue graft. (17001834)
2006
26
Apoptosis in cyclosporin A-induced gingival overgrowth: a histological study. (15974838)
2005
27
Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts. (15324353)
2004
28
Effects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cells]. (15196384)
2004
29
The immunosuppressant and hyperplasia-inducing drug cyclosporin A regulates the cell cycle and cyclin B1 gene expression in gingival fibroblasts in vitro. (15221438)
2004
30
Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients. (15732868)
2004
31
The epidemiology, etiology, and pathophysiology of acute necrotizing ulcerative gingivitis associated with malnutrition. (15318254)
2004
32
An experimental gingivitis study to evaluate the clinical effects of a stannous fluoride dentifrice. (16296255)
2004
33
Interleukin-1beta, clinical parameters and matched cellular-histopathologic changes of biopsied gingival tissue from periodontitis patients. (12753361)
2003
34
Expression of endothelin-1 in gingival epithelial cells. (12828660)
2003
35
Reduced gingival fluid flow: a peripheral marker of the pharmacological effect of roquinimex. (15035809)
2003
36
Effects of interleukin-4 on proteoglycan accumulation in human gingival fibroblasts. (11842937)
2002
37
Localized gingival recession caused by a C-PAP mask: a case report. (12451912)
2002
38
IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. (12237122)
2002
39
Comparative 6-month clinical study of a subepithelial connective tissue graft and acellular dermal matrix graft for the treatment of gingival recession. (11759858)
2001
40
Human gingival crevicular fluid contains MRP8 (S100A8) and MRP14 (S100A9), two calcium-binding proteins of the S100 family. (10728975)
2000
41
Analysis of gingival crevicular fluid intracytoplasmic enzyme activity in patients with adult periodontitis and rapidly progressive periodontitis. A longitudinal study model with periodontal treatment. (9802716)
1998
42
Evaluation of osteocalcin and pyridinium crosslinks of bone collagen as markers of bone turnover in gingival crevicular fluid during different stages of orthodontic treatment. (9667483)
1998
43
Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases. (9010272)
1997
44
Human papillomavirus in a patient with severe gingival overgrowth associated with cyclosporine therapy. A case report. (8724712)
1996
45
Bacterial proteases in gingival crevicular fluid before and after periodontal treatment. (7893545)
1995
46
Altered collagen metabolism in nifedipine-induced gingival overgrowth. (7877076)
1994
47
Gingival fluid IL-1 beta and IL-6 levels in menopause. (8126239)
1994
48
Hypertrichosis universalis congenita: a separate entity, or the same disease as gingival fibromatosis? (8415305)
1993
49
Interleukin-1 beta in the gingival tissues of patients with periodontitis: immunohistochemical data]. (8510615)
1993
50
Spirochetes in early lesions of necrotizing ulcerative gingivitis experimentally induced in beagles. (2087354)
1990

Variations for Gingivitis

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Expression for genes affiliated with Gingivitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gingivitis

Search GEO for disease gene expression data for Gingivitis.

Pathways for genes affiliated with Gingivitis

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51PathCards, 13EMD Millipore, 56Reactome, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN
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Compounds for genes affiliated with Gingivitis

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Sources:
46Novoseek, 3BitterDB, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 25HMDB, 52PharmGKB
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Compounds related to Gingivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
14-nitroanilide4610.0CTSG, ELANE
2elastatinal4610.0ELANE, CTSG
3saccharin46 310.9ELANE, CTSG
4barbiturate469.9MMP13, MMP8
5scca1469.8CTSG, SERPINB2
6ulinastatin469.6ELANE, GUSB
7cytochalasin b469.6ELANE, GUSB, CTSG
8hocl469.6MMP8, ELANE, CTSG
9tenidap46 3010.5IL1A, ELANE
10hydroxamate469.5MMP13, SERPINB2, MMP8
11thermolysin469.5MMP13, CTSG, ELANE
12benzphetamine46 1210.4IL1A, GUSB
13batimastat46 62 1211.4MMP13, ELANE, MMP8
14doxycycline46 1210.4MMP8, ELANE, MMP13
15vancomycin46 1210.3ELANE, CST3
16sodium dodecylsulfate469.3CTSG, ELANE, IL1A
17kininogen469.1CTSG, CST3, ELANE
18(4-aminophenyl)mercuric acetate469.1CTSG, ELANE, MMP8, MMP13
19urea46 25 1211.1CTSG, CST3, MMP8
20n-formylmethionyl-leucylphenylalanine469.1GUSB, ELANE, IL1A, CTSG
21leukotriene b446 62 2511.0IL1A, GUSB, ELANE, CTSG
22fmlp469.0GUSB, CTSG, IL1A, ELANE
23egcg469.0ELANE, MMP13, IL1A
24tetracycline46 1210.0MMP8, MMP13, GUSB, IL1A
25glycosaminoglycan469.0MMP8, IL1A, MMP13, GUSB
26p002469.0MMP13, MMP8, CST3
27endotoxin468.9IL1A, ELANE, CTSG, SERPINB2
28genistein46 30 62 3 25 1213.9MMP8, MMP13, IL1A, GUSB
29captopril46 62 52 30 1212.9IL1A, CST3, ELANE
30hyaluronic acid46 259.9MMP13, ELANE, IL1A
31cycloheximide468.7CTSG, IL1A, SERPINB2, MMP13
32hydrogen46 259.7CTSG, CST3, SERPINB2, MMP8
33prostacyclin468.7CTSG, IL1A, ELANE
34creatinine468.6GUSB, IL1A, CST3, CTSG
35aspartate468.6CTSG, CST3, IL1A, GUSB
36h2o2468.5IL1A, SERPINB2, CTSG, ELANE, MMP8
37nitric oxide46 25 1210.5MMP13, MMP8, SERPINB2, IL1A, CTSG
38lactate468.4CTSG, GUSB, CST3, MMP8, ELANE
39cysteine468.2ELANE, MMP8, MMP13, CST3, CTSG
40heparin46 30 25 1211.1SERPINB2, MMP13, ELANE, GUSB, IL1A, CTSG
41cyclosporin a46 30 6210.1CST3, IL1A, MMP8, ELANE, SERPINB2
42dexamethasone46 52 30 1211.1SERPINB2, MMP13, CST3, IL1A
43pge2468.0SERPINB2, GUSB, MMP13, IL1A, MMP8, ELANE
44vegf468.0MMP13, SERPINB2, IL1A, CST3, MMP8
45retinoic acid46 259.0IL1A, ELANE, SERPINB2, MMP13, MMP8, CTSG
46superoxide46 259.0CTSG, GUSB, CST3, ELANE, MMP8, SERPINB2
47calcium46 52 25 1210.8CTSG, MMP8, MMP13, SERPINB2, GUSB, CST3
48fibrinogen467.8ELANE, CST3, MMP8, MMP13, SERPINB2, CTSG
49aprotinin46 128.6CST3, CTSG, IL1A, SERPINB2, MMP13, ELANE
50serine467.2CST3, ELANE, MMP8, MMP13, SERPINB2, IL1A

GO Terms for genes affiliated with Gingivitis

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17Gene Ontology
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Cellular components related to Gingivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.3CTSG, ELANE
2extracellular vesicular exosomeGO:0700628.4CTSG, CST3, ELANE, GUSB
3extracellular spaceGO:0056157.2SERPINB2, MMP13, MMP8, IL1A, CST3, CTSG
4extracellular regionGO:0055766.7CTSG, SERPINB2, MMP13, MMP8, ELANE, IL1A

Biological processes related to Gingivitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immune responseGO:0507789.5ELANE, CTSG
2negative regulation of growth of symbiont in hostGO:0441309.3CTSG, ELANE
3negative regulation of endopeptidase activityGO:0109519.2CST3, SERPINB2
4collagen catabolic processGO:0305749.0ELANE, MMP8, MMP13
5extracellular matrix disassemblyGO:0226178.8CTSG, ELANE, MMP8, MMP13
6proteolysisGO:0065088.8MMP13, MMP8, ELANE, CTSG
7extracellular matrix organizationGO:0301988.7MMP13, MMP8, ELANE, CTSG

Molecular functions related to Gingivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.6CTSG, ELANE
2serine-type endopeptidase activityGO:0042529.1CTSG, ELANE, MMP8
3protease bindingGO:0020208.8CST3, ELANE

Products for genes affiliated with Gingivitis

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  • Antibodies
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Sources for Gingivitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet