MCID: GLN002
MIFTS: 43

Glanders malady

Rare diseases, Infectious diseases, Endocrine diseases categories
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Summaries for Glanders

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Sources:
8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in septicemic infection, has material basis in burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. the infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards: Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and melioidosis, susceptibilty to, and has symptoms including nodular lesions in the lungs, mucopurulent nasal discharge and headache. An important gene associated with Glanders is PASK (PAS domain containing serine/threonine kinase). The compounds adp and glucose have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes, and related mouse phenotypes are liver/biliary system and nervous system.

CDC:4 Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, glanders is primarily a disease affecting horses. It also affects donkeys and mules and can be naturally contracted by other mammals such as goats, dogs, and cats.

Wikipedia:65 Glanders (from Middle English glaundres or Old French glandres, both meaning glands) (Latin: Malleus... more...

Aliases & Classifications for Glanders

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

glanders 8 43 10 62
infection due to pseudomonas mallei 8
burkholderia mallei infection 43
burkholderia mallei 43
farcy pipes 8


External Ids:

Disease Ontology8 DOID:13444
ICD9CM27 024
MeSH35 D005896
SNOMED-CT58 4639008, 35322000
NCIt40 C34638
ICD1025 A24.0

Related Diseases for Glanders

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Glanders via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1melioidosis10.7
2melioidosis, susceptibilty to10.3
3tuberculosis10.2
4pemphigus10.0
5lymphangitis10.0
6actinomycosis10.0
7q fever10.0
8tick-borne relapsing fever10.0
9brucellosis10.0
10relapsing fever10.0
11pemphigus vegetans10.0

Graphical network of diseases related to Glanders:



Diseases related to glanders

Symptoms for Glanders

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8Disease Ontology
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Symptoms:

8 (show all 9)
  • nodular lesions in the lungs
  • mucopurulent nasal discharge
  • headache
  • muscle tightness
  • chest pain
  • muscle aches
  • sweating
  • chills
  • fever

Drugs & Therapeutics for Glanders

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Glanders

Search NIH Clinical Center for Glanders

Genetic Tests for Glanders

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Anatomical Context for Glanders

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33MalaCards
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MalaCards organs/tissues related to Glanders:

33
Lung, Eye, Testes, Liver, Spleen, Bone

Animal Models for Glanders or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Glanders:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0PASK, LRP5
2MP:00036318.4STK39, PASK, LRP5
3MP:00053768.2STK39, PASK, LRP5

Publications for Glanders

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52PubMed
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Articles related to Glanders:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Assessment of the effectiveness of the PPD-mallein produced in Brazil for diagnosing glanders in mules. (24159303)
2013
2
Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. (23517714)
2013
3
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. (22360070)
2012
4
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. (22912938)
2012
5
Development and validation of a method for purification of mallein for the diagnosis of glanders in equines. (22937975)
2012
6
Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. (22515029)
2012
7
Recent progress in melioidosis and glanders. (22529846)
2012
8
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders. (23205347)
2012
9
Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. (22718333)
2012
10
Protective antigens against glanders identified by expression library immunization. (22125550)
2011
11
Re-emergence of glanders in India - Report of Maharashtra state. (23100851)
2010
12
Molecular epidemiology of glanders, Pakistan. (19961695)
2009
13
Glanders: off to the races with Burkholderia mallei. (18031330)
2007
14
Detection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected mice. (17908615)
2007
15
Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. (17362501)
2007
16
Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. (12734250)
2003
17
Other bacterial diseases as a potential consequence of bioterrorism: Q fever, brucellosis, glanders, and melioidosis. (12833721)
2003
18
Glanders in a military research microbiologist. (11474663)
2001
19
Glanders in a military research microbiologist. (11757519)
2001
20
Laboratory-acquired human glanders--Maryland, May 2000. (10923853)
2000
21
Serodiagnosis of equine piroplasmosis, dourine, and glanders using an arrayed immunoblotting method. (10353365)
1999
22
Equine glanders in Turkey. (10209817)
1999
23
Early methods for the surveillance and control of glanders in Europe. (8038452)
1994
24
History of glanders and early veterinary medicine. (17422155)
1982
25
Pathology of glanders in horses in Iraq. (695232)
1978
26
Serological diagnosis of glanders by haemagglutination test. (5949908)
1966
27
Glanders. (15431372)
1950
28
Mixed infection of glanders and epizootic lymphangitis in a horse. (20251209)
1947
29
Human glanders; report of six cases. (20278465)
1947
30
Glanders in the ass. (21013331)
1945
31
A CASE OF ACUTE GLANDERS. (20776943)
1932
32
Melioidosis and its Relation to Glanders. (20474845)
1925
33
Serum Treatment of Glanders. (20314657)
1923
34
Notes on Complement Fixation in Glanders. (19972115)
1913
35
An Account of a Glanders-like Disease occurring in Rangoon. (20474526)
1913
36
Chronic Glanders in a Man aged 24. (19974336)
1910
37
Committee on Standard Methods for the Bacterial Diagnosis of Glanders. (19599343)
1909
38
Observations ON HUMAN GLANDERS: WITH A STUDY OF SIX CASES AND A DISCUSSION OF THE METHODS OF DIAGNOSIS. (20764286)
1909
39
A Case of Human Glanders. (18733530)
1905
40
VII. Pyaemic Glanders in the Human Subject. Report of a Recent Case of Laboratory Origin terminating in Recovery. (17861483)
1904
41
A Case of Septicemic Glanders in the Human Subject. (19971532)
1903
42
Methods of Diagnosis in Glanders. (19601017)
1901
43
Glanders in London. (20753859)
1892
44
II. On the Present State of Knowledge in Bacterial Science in its Surgical Relations (Concluded): Actinomycosis-Anthrax-Glanders. (17856094)
1886
45
CASE OF GLANDERS IN A FEMALE. (20740797)
1853
46
A Case of Glanders in the Human Subject. (21379272)
1843
47
Case of Glanders: Produced by the Absorption of Matter from a Horse. (21372993)
1842
48
Observations on Glanders. (21380143)
1841
49
Academy of Sciences. Paris: Communication of glanders from one individual to another. Paris, November 15. (21379803)
1841
50
Additional Facts respecting Glanders in the Human Subject. (20895601)
1833

Variations for Glanders

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Expression for genes affiliated with Glanders

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for genes affiliated with Glanders

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Compounds for genes affiliated with Glanders

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Glanders according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1adp45 29 2411.2STK39, PASK
2glucose459.0PASK, LRP5
3Adenosine triphosphate24 1110.0STK39, PASK

GO Terms for genes affiliated with Glanders

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16Gene Ontology
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Biological processes related to Glanders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphorylationGO:0064689.3STK39, PASK

Products for genes affiliated with Glanders

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glanders

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet