MCID: GLN002
MIFTS: 35

Glanders

Categories: Rare diseases, Infectious diseases, Endocrine diseases

Aliases & Classifications for Glanders

MalaCards integrated aliases for Glanders:

Name: Glanders 12 50 3 42 14 69
Infection Due to Pseudomonas Mallei 12
Burkholderia Mallei Infection 50
Burkholderia Mallei 50
Farcy Pipes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13444
ICD10 33 A24.0
ICD9CM 35 024
MeSH 42 D005896
NCIt 47 C34638
SNOMED-CT 64 35322000 4639008
UMLS 69 C0017589

Summaries for Glanders

Disease Ontology : 12 A primary bacterial infectious disease that results_in septicemic infection, has material basis in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards based summary : Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and optic nerve hypoplasia. An important gene associated with Glanders is KRT3 (Keratin 3), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Melphalan and Menthol have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes, and related phenotype is liver/biliary system.

CDC : 3 Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, glanders is primarily a disease affecting horses. It also affects donkeys and mules and can be naturally contracted by other mammals such as goats, dogs, and cats.

Wikipedia : 72 Glanders (from Middle English glaundres or Old French glandres, both meaning glands;Latin: malleus,... more...

Related Diseases for Glanders

Diseases related to Glanders via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
id Related Disease Score Top Affiliating Genes
1 melioidosis 10.9
2 optic nerve hypoplasia 9.9 KRT3 TLR4
3 tuberculosis 9.8
4 ethmoid sinus cancer 9.8 HCFC1 TLR4
5 tick-borne relapsing fever 9.7
6 actinomycosis 9.7
7 pemphigus 9.7
8 lymphangitis 9.7
9 pemphigus vegetans 9.7
10 brucellosis 9.7
11 q fever 9.7
12 relapsing fever 9.7
13 brain injury 9.6 LRP5 TLR4
14 osteochondritis dissecans 9.2 PSAP TLR4
15 posterior corneal pigmentation 8.0 HCFC1 KRT3 LRP5 PSAP TLR4

Graphical network of the top 20 diseases related to Glanders:



Diseases related to Glanders

Symptoms & Phenotypes for Glanders

MGI Mouse Phenotypes related to Glanders:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.8 LRP5 PSAP TLR4

Drugs & Therapeutics for Glanders

Drugs for Glanders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 4053 460612
2
Menthol Approved Phase 1 2216-51-5 16666
3 Anesthetics Phase 1
4 Alkylating Agents Phase 1
5 Immunosuppressive Agents Phase 1
6
Chloroprocaine Approved 133-16-4 8612
7
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
8
Imidacloprid Vet_approved 105827-78-9 86418
9 Anesthetics, Local
10 Central Nervous System Depressants
11 Peripheral Nervous System Agents
12 Analgesics
13 Analgesics, Non-Narcotic
14 Anti-Inflammatory Agents
15 Anti-Inflammatory Agents, Non-Steroidal
16 Antirheumatic Agents

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 Glaucoma Treatment by Cyclo-coagulation Using High Intensity Focused Ultrasound (HIFU) Completed NCT01592955 Phase 4
2 Spinal Magnetic Stimulation in Neuropathic Pain Completed NCT00443469 Phase 3
3 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
4 Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases Recruiting NCT03028337 Phase 2
5 Trial for Salvage Re-Irradiation of Metastatic Spine Lesions Using Single-Fraction Stereotactic Radiosurgery Recruiting NCT02278744 Phase 1
6 Intra-arterial Chemotherapy for Spinal Metastases Recruiting NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
7 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056
8 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328
9 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
10 The Effect of Spinal Flexion in the Lateral Decubitus Position on the Unilaterality During Spinal Anesthesia Completed NCT01321684
11 Glaucoma Treatment by Circular Cyclocoagulation Using High Intensity Focused Ultrasound With the EYEOP Medical Device Completed NCT01338467
12 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
13 Implementation of a "Remission" Consultation in the Management of Patients Treated for Localized Breast Cancer Recruiting NCT02740491
14 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Not yet recruiting NCT02806167

Search NIH Clinical Center for Glanders

Cochrane evidence based reviews: glanders

Genetic Tests for Glanders

Anatomical Context for Glanders

MalaCards organs/tissues related to Glanders:

39
Lung, Eye, Testes, Breast, Liver, Bone, Spleen

Publications for Glanders

Articles related to Glanders:

(show top 50) (show all 136)
id Title Authors Year
1
Glanders And Melioidosis ( 28846298 )
2017
2
Seroprevalence and risk factors of glanders in working equines - Findings of a cross-sectional study in Punjab province of Pakistan. ( 28760480 )
2017
3
Identification of a new diagnostic antigen for glanders using immunoproteome analysis. ( 28750864 )
2017
4
Harmonising diagnostic testing for glanders in equids. ( 27313253 )
2016
5
Glanders and history. ( 27339929 )
2016
6
Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders. ( 27271739 )
2016
7
Glanders and the risk for its introduction through the international movement of horses. ( 27288893 )
2016
8
Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches. ( 27010618 )
2016
9
Interlaboratory ring trial to evaluate CFT proficiency of European laboratories for diagnosis of glanders in equines. ( 27122499 )
2016
10
Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice. ( 26955620 )
2016
11
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders. ( 26148026 )
2015
12
Efficacy of Postexposure Therapy against Glanders in Mice. ( 25645854 )
2015
13
From glanders to globulins: A study in comparative medicine. ( 26307410 )
2015
14
Pathological findings and diagnostic implications of a rhesus macaque (Macacca mulatta) model of aerosol-exposure to Burkholderia mallei (glanders). ( 25850696 )
2015
15
Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. ( 25533326 )
2015
16
Surveillance focus: glanders. ( 26183359 )
2015
17
Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus). ( 25477002 )
2014
18
Genotyping of Burkholderia mallei from an outbreak of glanders in Bahrain suggests multiple introduction events. ( 25255232 )
2014
19
Optimization and validation of indirect ELISA using truncated TssB protein for the serodiagnosis of glanders amongst equines. ( 24672321 )
2014
20
Effect of incubation temperature on the diagnostic sensitivity of the glanders complement fixation test. ( 25812210 )
2014
21
Assessment of the effectiveness of the PPD-mallein produced in Brazil for diagnosing glanders in mules. ( 24159303 )
2013
22
From glanders to Hendra virus: 125 years of equine infectious diseases. ( 23997164 )
2013
23
Glanders in animals: a review on epidemiology, clinical presentation, diagnosis and countermeasures. ( 22630609 )
2013
24
Glanders: an overview of infection in humans. ( 24004906 )
2013
25
Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. ( 23517714 )
2013
26
Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. ( 22515029 )
2012
27
Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. ( 22718333 )
2012
28
Glanders outbreak at Tehran Zoo, Iran. ( 22783454 )
2012
29
Recent progress in melioidosis and glanders. ( 22529846 )
2012
30
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. ( 22912938 )
2012
31
Humoral immune responses in a human case of glanders. ( 22398248 )
2012
32
Development and validation of a method for purification of mallein for the diagnosis of glanders in equines. ( 22937975 )
2012
33
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders. ( 23205347 )
2012
34
Evaluation of recombinant proteins of Burkholderia mallei for serodiagnosis of glanders. ( 22695165 )
2012
35
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. ( 22360070 )
2012
36
Effectiveness of an antimicrobial treatment scheme in a confined glanders outbreak. ( 23134717 )
2012
37
Comparative evaluation of three commercially available complement fixation test antigens for the diagnosis of glanders. ( 21896565 )
2011
38
Protective antigens against glanders identified by expression library immunization. ( 22125550 )
2011
39
Use of a recombinant burkholderia intracellular motility a protein for immunodiagnosis of glanders. ( 21752949 )
2011
40
Use of a Western blot technique for the serodiagnosis of glanders. ( 21247488 )
2011
41
Diagnostic assays for glanders. ( 22184353 )
2011
42
Glanders in donkeys (Equus Asinus) in the state of pernambuco, Brazil: A case report. ( 24031474 )
2010
43
Present and future therapeutic strategies for melioidosis and glanders. ( 20192686 )
2010
44
Re-emergence of glanders in India - Report of Maharashtra state. ( 23100851 )
2010
45
Molecular epidemiology of glanders, Pakistan. ( 19961695 )
2009
46
Prevalence-dependent use of serological tests for diagnosing glanders in horses. ( 19723336 )
2009
47
Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. ( 19490962 )
2009
48
Glanders. ( 18710311 )
2008
49
Glanders: off to the races with Burkholderia mallei. ( 18031330 )
2007
50
Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. ( 17362501 )
2007

Variations for Glanders

Expression for Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for Glanders

Pathways related to Glanders according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.17 LRP5 TLR4
2 10.49 LRP5 TLR4

GO Terms for Glanders

Cellular components related to Glanders according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.32 LRP5

Biological processes related to Glanders according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 8.8 HCFC1 LRP5 TLR4

Sources for Glanders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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