MCID: GLN002
MIFTS: 35

Glanders malady

Categories: Rare diseases, Infectious diseases, Endocrine diseases

Aliases & Classifications for Glanders

Aliases & Descriptions for Glanders:

Name: Glanders 12 50 3 42 14 69
Infection Due to Pseudomonas Mallei 12
Burkholderia Mallei Infection 50
Burkholderia Mallei 50
Farcy Pipes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13444
ICD10 33 A24.0
ICD9CM 35 024
MeSH 42 D005896
NCIt 47 C34638
SNOMED-CT 64 35322000 4639008
UMLS 69 C0017589

Summaries for Glanders

Disease Ontology : 12 A primary bacterial infectious disease that results_in septicemic infection, has material basis in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards based summary : Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and tuberculosis, and has symptoms including fever, chills and sweating. An important gene associated with Glanders is KRT3 (Keratin 3). The drugs Melphalan and Menthol have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes.

CDC : 3 Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, glanders is primarily a disease affecting horses. It also affects donkeys and mules and can be naturally contracted by other mammals such as goats, dogs, and cats.

Wikipedia : 71 Glanders (from Middle English glaundres or Old French glandres, both meaning glands;Latin: malleus,... more...

Related Diseases for Glanders

Diseases related to Glanders via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
id Related Disease Score Top Affiliating Genes
1 melioidosis 10.9
2 tuberculosis 9.8
3 idiopathic progressive polyneuropathy 9.8 HSPD1 PSAP
4 q fever 9.7
5 relapsing fever 9.7
6 tick-borne relapsing fever 9.7
7 actinomycosis 9.7
8 pemphigus 9.7
9 lymphangitis 9.7
10 pemphigus vegetans 9.7
11 brucellosis 9.7
12 posterior corneal pigmentation 9.1 HCFC1 HSPD1 KRT3 LRP5 PSAP

Graphical network of the top 20 diseases related to Glanders:



Diseases related to Glanders

Symptoms & Phenotypes for Glanders

Symptoms:

12
  • fever
  • chills
  • sweating
  • muscle aches
  • chest pain
  • muscle tightness
  • headache
  • mucopurulent nasal discharge
  • nodular lesions in the lungs

Drugs & Therapeutics for Glanders

Drugs for Glanders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 4053 460612
2
Menthol Approved Phase 1 2216-51-5 16666
3 Anesthetics Phase 1
4 Alkylating Agents Phase 1
5 Antineoplastic Agents, Alkylating Phase 1
6 Immunosuppressive Agents Phase 1
7
Chloroprocaine Approved 133-16-4 8612
8
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
9 Anesthetics, Local
10 Central Nervous System Depressants
11 Peripheral Nervous System Agents
12 Analgesics
13 Analgesics, Non-Narcotic
14 Anti-Inflammatory Agents
15 Anti-Inflammatory Agents, Non-Steroidal
16 Antirheumatic Agents
17
Imidacloprid 105827-78-9 86418

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Glaucoma Treatment by Cyclo-coagulation Using High Intensity Focused Ultrasound (HIFU) Completed NCT01592955 Phase 4
2 Spinal Magnetic Stimulation in Neuropathic Pain Completed NCT00443469 Phase 3
3 Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases Recruiting NCT03028337 Phase 2
4 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Not yet recruiting NCT02591901 Phase 2
5 Trial for Salvage Re-Irradiation of Metastatic Spine Lesions Using Single-Fraction Stereotactic Radiosurgery Recruiting NCT02278744 Phase 1
6 Intra-arterial Chemotherapy for Spinal Metastases Recruiting NCT01637766 Phase 1
7 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056
8 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328
9 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806
10 The Effect of Spinal Flexion in the Lateral Decubitus Position on the Unilaterality During Spinal Anesthesia Completed NCT01321684
11 Glaucoma Treatment by Circular Cyclocoagulation Using High Intensity Focused Ultrasound With the EYEOP Medical Device Completed NCT01338467
12 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
13 Implementation of a "Remission" Consultation in the Management of Patients Treated for Localized Breast Cancer Recruiting NCT02740491
14 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Not yet recruiting NCT02806167

Search NIH Clinical Center for Glanders

Cochrane evidence based reviews: glanders

Genetic Tests for Glanders

Anatomical Context for Glanders

MalaCards organs/tissues related to Glanders:

39
Lung, Eye, Testes, Bone, Liver, Spleen

Publications for Glanders

Articles related to Glanders:

(show top 50) (show all 133)
id Title Authors Year
1
Glanders and history. ( 27339929 )
2016
2
Harmonising diagnostic testing for glanders in equids. ( 27313253 )
2016
3
Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches. ( 27010618 )
2016
4
Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders. ( 27271739 )
2016
5
Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice. ( 26955620 )
2016
6
Glanders and the risk for its introduction through the international movement of horses. ( 27288893 )
2016
7
Interlaboratory ring trial to evaluate CFT proficiency of European laboratories for diagnosis of glanders in equines. ( 27122499 )
2016
8
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders. ( 26148026 )
2015
9
Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. ( 25533326 )
2015
10
From glanders to globulins: A study in comparative medicine. ( 26307410 )
2015
11
Surveillance focus: glanders. ( 26183359 )
2015
12
Efficacy of Postexposure Therapy against Glanders in Mice. ( 25645854 )
2015
13
Pathological findings and diagnostic implications of a rhesus macaque (Macacca mulatta) model of aerosol-exposure to Burkholderia mallei (glanders). ( 25850696 )
2015
14
Genotyping of Burkholderia mallei from an outbreak of glanders in Bahrain suggests multiple introduction events. ( 25255232 )
2014
15
Optimization and validation of indirect ELISA using truncated TssB protein for the serodiagnosis of glanders amongst equines. ( 24672321 )
2014
16
Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus). ( 25477002 )
2014
17
Effect of incubation temperature on the diagnostic sensitivity of the glanders complement fixation test. ( 25812210 )
2014
18
Glanders in animals: a review on epidemiology, clinical presentation, diagnosis and countermeasures. ( 22630609 )
2013
19
Assessment of the effectiveness of the PPD-mallein produced in Brazil for diagnosing glanders in mules. ( 24159303 )
2013
20
Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. ( 23517714 )
2013
21
From glanders to Hendra virus: 125 years of equine infectious diseases. ( 23997164 )
2013
22
Glanders: an overview of infection in humans. ( 24004906 )
2013
23
Humoral immune responses in a human case of glanders. ( 22398248 )
2012
24
Development and validation of a method for purification of mallein for the diagnosis of glanders in equines. ( 22937975 )
2012
25
Evaluation of recombinant proteins of Burkholderia mallei for serodiagnosis of glanders. ( 22695165 )
2012
26
Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. ( 22718333 )
2012
27
Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. ( 22515029 )
2012
28
Recent progress in melioidosis and glanders. ( 22529846 )
2012
29
Glanders outbreak at Tehran Zoo, Iran. ( 22783454 )
2012
30
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders. ( 23205347 )
2012
31
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. ( 22912938 )
2012
32
Effectiveness of an antimicrobial treatment scheme in a confined glanders outbreak. ( 23134717 )
2012
33
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. ( 22360070 )
2012
34
Use of a recombinant burkholderia intracellular motility a protein for immunodiagnosis of glanders. ( 21752949 )
2011
35
Comparative evaluation of three commercially available complement fixation test antigens for the diagnosis of glanders. ( 21896565 )
2011
36
Diagnostic assays for glanders. ( 22184353 )
2011
37
Use of a Western blot technique for the serodiagnosis of glanders. ( 21247488 )
2011
38
Protective antigens against glanders identified by expression library immunization. ( 22125550 )
2011
39
Glanders in donkeys (Equus Asinus) in the state of pernambuco, Brazil: A case report. ( 24031474 )
2010
40
Re-emergence of glanders in India - Report of Maharashtra state. ( 23100851 )
2010
41
Present and future therapeutic strategies for melioidosis and glanders. ( 20192686 )
2010
42
Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. ( 19490962 )
2009
43
Molecular epidemiology of glanders, Pakistan. ( 19961695 )
2009
44
Prevalence-dependent use of serological tests for diagnosing glanders in horses. ( 19723336 )
2009
45
Glanders. ( 18710311 )
2008
46
Glanders: off to the races with Burkholderia mallei. ( 18031330 )
2007
47
Detection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected mice. ( 17908615 )
2007
48
Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. ( 17362501 )
2007
49
Comparative evaluation of Rose Bengal plate agglutination test, mallein test, and some conventional serological tests for diagnosis of equine glanders. ( 17609344 )
2007
50
Burkholderia mallei and Burkholderia pseudomallei: the causative micro-organisms of glanders and melioidosis. ( 18221181 )
2007

Variations for Glanders

Expression for Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for Glanders

GO Terms for Glanders

Biological processes related to Glanders according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 8.62 HCFC1 HSPD1

Sources for Glanders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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