MCID: GLN002
MIFTS: 48

Glanders malady

Infectious diseases, Endocrine diseases categories

Summaries for Glanders

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in septicemic infection, has material basis in burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. the infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards: Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and melioidosis, susceptibilty to, and has symptoms including nodular lesions in the lungs, mucopurulent nasal discharge and muscle tightness. An important gene associated with Glanders is KLF1 (Kruppel-like factor 1 (erythroid)), and among its related pathways are PI Metabolism and Inositol phosphate metabolism. The compounds aclacinomycin and inositol 1,3,4,5-tetrakisphosphate have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes.

CDC:3 Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, glanders is primarily a disease affecting horses. It also affects donkeys and mules and can be naturally contracted by other mammals such as goats, dogs, and cats.

Wikipedia:63 Glanders (from Middle English glaundres or Old French glandres, both meaning glands) (Latin: Malleus... more...

Aliases & Classifications for Glanders

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

glanders 8 42 10 60
infection due to pseudomonas mallei 8
burkholderia mallei infection 42
burkholderia mallei 42
farcy pipes 8


External Ids:

Disease Ontology8 DOID:13444
NCIt39 C34638
MeSH34 D005896
SNOMED-CT56 4639008, 35322000
ICD9CM27 024
ICD1025 A24.0

Related Diseases for Glanders

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Glanders:



Diseases related to glanders

Clinical Features for Glanders

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8Disease Ontology
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Symptoms:

8 (show all 9)
  • nodular lesions in the lungs
  • mucopurulent nasal discharge
  • muscle tightness
  • sweating
  • muscle aches
  • chills
  • chest pain
  • headache
  • fever

Drugs & Therapeutics for Glanders

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glanders

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Anatomical Context for Glanders

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32MalaCards
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MalaCards organs/tissues related to Glanders:

32
Lung, Eye, Testes, Spleen, Liver, Bone

Animal Models for Glanders or affiliated genes

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Publications for Glanders

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50PubMed
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Articles related to Glanders:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
From glanders to Hendra virus: 125 years of equine infectious diseases. (23997164)
2013
2
Development and validation of a method for purification of mallein for the diagnosis of glanders in equines. (22937975)
2012
3
Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. (22515029)
2012
4
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders. (23205347)
2012
5
Glanders outbreak at Tehran Zoo, Iran. (22783454)
2012
6
Evaluation of recombinant proteins of Burkholderia mallei for serodiagnosis of glanders. (22695165)
2012
7
Protective antigens against glanders identified by expression library immunization. (22125550)
2011
8
Use of a recombinant burkholderia intracellular motility a protein for immunodiagnosis of glanders. (21752949)
2011
9
Use of a Western blot technique for the serodiagnosis of glanders. (21247488)
2011
10
Re-emergence of glanders in India - Report of Maharashtra state. (23100851)
2010
11
Present and future therapeutic strategies for melioidosis and glanders. (20192686)
2010
12
Molecular epidemiology of glanders, Pakistan. (19961695)
2009
13
Prevalence-dependent use of serological tests for diagnosing glanders in horses. (19723336)
2009
14
Glanders. (18710311)
2008
15
Glanders: off to the races with Burkholderia mallei. (18031330)
2007
16
Burkholderia mallei and Burkholderia pseudomallei: the causative micro-organisms of glanders and melioidosis. (18221181)
2007
17
Detection of the reemerging agent Burkholderia mallei in a recent outbreak of glanders in the United Arab Emirates by a newly developed fliP-based polymerase chain reaction assay. (16466896)
2006
18
Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse. (14614070)
2003
19
Glanders in a military research microbiologist. (11474663)
2001
20
In vitro antibiotic susceptibilities of Burkholderia mallei (causative agent of glanders) determined by broth microdilution and E-test. (11408233)
2001
21
Clinical image. Glanders disease of the liver and spleen: CT evaluation. (11176300)
2001
22
Laboratory-acquired human glanders--Maryland, May 2000. (10923853)
2000
23
Mouse model of sublethal and lethal intraperitoneal glanders (Burkholderia mallei). (11105952)
2000
24
Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders. (10837435)
2000
25
Serodiagnosis of equine piroplasmosis, dourine, and glanders using an arrayed immunoblotting method. (10353365)
1999
26
Potency of partially purified malleo-proteins for mallein test in the diagnosis of glanders in equines. (7801539)
1994
27
Serologic responses to the mallein test for glanders in solipeds. (8466990)
1993
28
Comparative efficacy of serological tests in the diagnosis of glanders. (4970533)
1968
29
Glanders. (15431372)
1950
30
The Glanders Organism with Reference to Its Cell Inclusions. (16560902)
1945
31
A CASE OF ACUTE GLANDERS. (20776943)
1932
32
Serum Treatment of Glanders. (20314657)
1923
33
THE LABORATORY DIAGNOSIS OF GLANDERS. (19599682)
1911
34
Committee on Standard Methods for the Bacterial Diagnosis of Glanders. (19599343)
1909
35
Observations ON HUMAN GLANDERS: WITH A STUDY OF SIX CASES AND A DISCUSSION OF THE METHODS OF DIAGNOSIS. (20764286)
1909
36
A Case of Septicemic Glanders in the Human Subject. (19971532)
1903
37
Methods of Diagnosis in Glanders. (19601017)
1901
38
The Diagnosis of Glanders by the Strauss Method. (19971435)
1901
39
The Report of the Departmental Committee on Glanders. (20758654)
1899
40
THE HISTOLOGIGAL LESIONS OF ACUTE GLANDERS IN MAN AND OF EXPERIMENTAL GLANDERS IN THE GUINEA-PIG. (19866814)
1896
41
The Morbid Anatomy of the Bones in Chronic Glanders in the Human Subject. (17232152)
1895
42
Glanders in London. (20753859)
1892
43
Glanders in Man, with the Report of a Case. (19600424)
1891
44
Acute Glanders in the Human Subject. (21380196)
1843
45
Case of Glanders: Produced by the Absorption of Matter from a Horse. (21372993)
1842
46
Propagation of Glanders by Infection. (21379464)
1842
47
Observations on Glanders. (21380143)
1841
48
Academy of Sciences. Paris: Communication of glanders from one individual to another. Paris, November 15. (21379803)
1841
49
Observations on Glanders. (21379587)
1841
50
On the Glanders in the Human Subject. (20895563)
1831

Genetic Variations for Glanders

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Expression for genes affiliated with Glanders

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for genes affiliated with Glanders

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Glanders

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Glanders according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aclacinomycin4410.4NFE2, GATA1
2inositol 1,3,4,5-tetrakisphosphate44 1111.3INPP5J, OCRL
3gestodene44 1111.3PAEP, CYP3A5
4porphobilinogen44 11 2412.2GATA1, NFE2
5aspartate4410.0CASP14, GATA1, DPP7, RETN, ENPEP
6lipid449.9OCRL, CD58, CYP3A5, RETN, INPP5J, GPX4
7retinoic acid44 2410.9CASP14, GATA1, ITGA3, CD58, CYP3A5, PAEP
8inositol449.9INPP5E, INPP5J, OCRL

GO Terms for genes affiliated with Glanders

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16Gene Ontology
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Biological processes related to Glanders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:03516210.3GATA1, KLF1
2phosphatidylinositol dephosphorylationGO:04685610.3OCRL, INPP5J, INPP5E
3phosphatidylinositol biosynthetic processGO:00666110.2INPP5E, INPP5J, OCRL
4phospholipid metabolic processGO:00664410.1PLA2G2D, GPX4, INPP5E, INPP5J, OCRL
5negative regulation of bone mineralizationGO:03050210.0NFE2, GATA1
6small molecule metabolic processGO:0442819.7OCRL, IMPDH2, CYP3A5, INPP5J, INPP5E, GPX4

Molecular functions related to Glanders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol-polyphosphate 5-phosphatase activityGO:00444510.3INPP5E, INPP5J
2phosphatidylinositol-4,5-bisphosphate 5-phosphatase activityGO:00443910.0INPP5E, OCRL

Products for genes affiliated with Glanders

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glanders

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet