MCID: GLN002
MIFTS: 36

Glanders malady

Rare diseases, Infectious diseases, Endocrine diseases categories

Aliases & Classifications for Glanders

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Glanders, Aliases & Descriptions:

Name: Glanders 9 41 11 3 60
Infection Due to Pseudomonas Mallei 9
Burkholderia Mallei Infection 41
 
Burkholderia Mallei 41
Farcy Pipes 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:13444
NCIt38 C34638
ICD9CM27 024
SNOMED-CT55 4639008, 35322000
MeSH33 D005896
ICD1025 A24.0

Summaries for Glanders

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Disease Ontology:9 A primary bacterial infectious disease that results in septicemic infection, has material basis in burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. the infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards based summary: Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and tuberculosis, and has symptoms including fever, chills and sweating. An important gene associated with Glanders is PASK (PAS domain containing serine/threonine kinase). The compounds adp and glucose have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes, and related mouse phenotypes are liver/biliary system and nervous system.

Wikipedia:63 Ned Glanders Glancisidor (from Middle English glaundres or Old French glandres, both meaning glands,... more...

Related Diseases for Glanders

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Diseases related to Glanders via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1melioidosis10.7
2tuberculosis10.2
3pemphigus10.0
4lymphangitis10.0
5actinomycosis10.0
6q fever10.0
7tick-borne relapsing fever10.0
8brucellosis10.0
9relapsing fever10.0
10pemphigus vegetans10.0

Graphical network of diseases related to Glanders:



Diseases related to glanders

Symptoms for Glanders

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Symptoms:

 9 (show all 9)
  • fever
  • chills
  • sweating
  • muscle aches
  • chest pain
  • muscle tightness
  • headache
  • mucopurulent nasal discharge
  • nodular lesions in the lungs

Drugs & Therapeutics for Glanders

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Drug clinical trials:

Search ClinicalTrials for Glanders

Search NIH Clinical Center for Glanders

Genetic Tests for Glanders

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Anatomical Context for Glanders

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MalaCards organs/tissues related to Glanders:

31
Lung, Eye, Testes, Bone, Spleen, Liver

Animal Models for Glanders or affiliated genes

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MGI Mouse Phenotypes related to Glanders:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0PASK, LRP5
2MP:00036318.4STK39, PASK, LRP5
3MP:00053768.2STK39, PASK, LRP5

Publications for Glanders

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Articles related to Glanders:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Efficacy of Postexposure Therapy against Glanders in Mice. (25645854)
2015
2
Pathological findings and diagnostic implications of a rhesus macaque (Macacca mulatta) model of aerosol-exposure to Burkholderia mallei (glanders). (25850696)
2015
3
Assessment of the effectiveness of the PPD-mallein produced in Brazil for diagnosing glanders in mules. (24159303)
2013
4
Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. (23517714)
2013
5
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. (22360070)
2012
6
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. (22912938)
2012
7
Development and validation of a method for purification of mallein for the diagnosis of glanders in equines. (22937975)
2012
8
Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. (22515029)
2012
9
Recent progress in melioidosis and glanders. (22529846)
2012
10
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders. (23205347)
2012
11
Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. (22718333)
2012
12
Protective antigens against glanders identified by expression library immunization. (22125550)
2011
13
Re-emergence of glanders in India - Report of Maharashtra state. (23100851)
2010
14
Molecular epidemiology of glanders, Pakistan. (19961695)
2009
15
Glanders: off to the races with Burkholderia mallei. (18031330)
2007
16
Detection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected mice. (17908615)
2007
17
Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. (17362501)
2007
18
Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. (12734250)
2003
19
Other bacterial diseases as a potential consequence of bioterrorism: Q fever, brucellosis, glanders, and melioidosis. (12833721)
2003
20
Glanders in a military research microbiologist. (11474663)
2001
21
Glanders in a military research microbiologist. (11757519)
2001
22
Laboratory-acquired human glanders--Maryland, May 2000. (10923853)
2000
23
Serodiagnosis of equine piroplasmosis, dourine, and glanders using an arrayed immunoblotting method. (10353365)
1999
24
Equine glanders in Turkey. (10209817)
1999
25
Early methods for the surveillance and control of glanders in Europe. (8038452)
1994
26
History of glanders and early veterinary medicine. (17422155)
1982
27
Pathology of glanders in horses in Iraq. (695232)
1978
28
Glanders. (15431372)
1950
29
Mixed infection of glanders and epizootic lymphangitis in a horse. (20251209)
1947
30
Human glanders; report of six cases. (20278465)
1947
31
Glanders in the ass. (21013331)
1945
32
A CASE OF ACUTE GLANDERS. (20776943)
1932
33
Melioidosis and its Relation to Glanders. (20474845)
1925
34
Serum Treatment of Glanders. (20314657)
1923
35
Notes on Complement Fixation in Glanders. (19972115)
1913
36
Chronic Glanders in a Man aged 24. (19974336)
1910
37
Committee on Standard Methods for the Bacterial Diagnosis of Glanders. (19599343)
1909
38
Observations ON HUMAN GLANDERS: WITH A STUDY OF SIX CASES AND A DISCUSSION OF THE METHODS OF DIAGNOSIS. (20764286)
1909
39
A Case of Human Glanders. (18733530)
1905
40
VII. Pyaemic Glanders in the Human Subject. Report of a Recent Case of Laboratory Origin terminating in Recovery. (17861483)
1904
41
A Case of Septicemic Glanders in the Human Subject. (19971532)
1903
42
Methods of Diagnosis in Glanders. (19601017)
1901
43
Glanders in London. (20753859)
1892
44
II. On the Present State of Knowledge in Bacterial Science in its Surgical Relations (Concluded): Actinomycosis-Anthrax-Glanders. (17856094)
1886
45
CASE OF GLANDERS IN A FEMALE. (20740797)
1853
46
Acute Glanders in the Human Subject. (21380196)
1843
47
Case of Glanders: Produced by the Absorption of Matter from a Horse. (21372993)
1842
48
Observations on Glanders. (21380143)
1841
49
Academy of Sciences. Paris: Communication of glanders from one individual to another. Paris, November 15. (21379803)
1841
50
Additional Facts respecting Glanders in the Human Subject. (20895601)
1833

Variations for Glanders

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Expression for genes affiliated with Glanders

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Search GEO for disease gene expression data for Glanders.

Pathways for genes affiliated with Glanders

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Compounds for genes affiliated with Glanders

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Sources:
43Novoseek, 28IUPHAR, 24HMDB, 12DrugBank
See all sources

Compounds related to Glanders according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1adp43 28 2411.2STK39, PASK
2glucose439.0PASK, LRP5
3Adenosine triphosphate24 1210.0STK39, PASK

GO Terms for genes affiliated with Glanders

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Biological processes related to Glanders according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein phosphorylationGO:00064689.3STK39, PASK

Products for genes affiliated with Glanders

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Glanders

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet