MCID: GLN002
MIFTS: 48

Glanders malady

Infectious diseases, Endocrine diseases categories

Summaries for Glanders

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in septicemic infection, has material basis in burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. the infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards: Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and melioidosis, susceptibilty to, and has symptoms including nodular lesions in the lungs, mucopurulent nasal discharge and headache. An important gene associated with Glanders is KLF1 (Kruppel-like factor 1 (erythroid)), and among its related pathways are PI Metabolism and Inositol phosphate metabolism. The compounds aclacinomycin and inositol 1,3,4,5-tetrakisphosphate have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes.

CDC:3 Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, glanders is primarily a disease affecting horses. It also affects donkeys and mules and can be naturally contracted by other mammals such as goats, dogs, and cats.

Wikipedia:63 Glanders (from Middle English glaundres or Old French glandres, both meaning glands) (Latin: Malleus... more...

Aliases & Classifications for Glanders

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

glanders 8 42 10 60
infection due to pseudomonas mallei 8
burkholderia mallei infection 42
burkholderia mallei 42
farcy pipes 8


External Ids:

Disease Ontology8 DOID:13444
NCIt39 C34638
MeSH34 D005896
SNOMED-CT56 4639008, 35322000
ICD9CM27 024
ICD1025 A24.0

Related Diseases for Glanders

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Glanders:



Diseases related to glanders

Clinical Features for Glanders

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • nodular lesions in the lungs
  • mucopurulent nasal discharge
  • headache
  • muscle tightness
  • chest pain
  • muscle aches
  • sweating
  • chills
  • fever

Drugs & Therapeutics for Glanders

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glanders

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Anatomical Context for Glanders

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32MalaCards
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MalaCards organs/tissues related to Glanders:

32
Lung, Eye, Testes, Liver, Spleen, Bone

Animal Models for Glanders or affiliated genes

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Publications for Glanders

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50PubMed
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Articles related to Glanders:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Assessment of the effectiveness of the PPD-mallein produced in Brazil for diagnosing glanders in mules. (24159303)
2013
2
Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. (23517714)
2013
3
Glanders: an overview of infection in humans. (24004906)
2013
4
Glanders in animals: a review on epidemiology, clinical presentation, diagnosis and countermeasures. (22630609)
2013
5
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. (22360070)
2012
6
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. (22912938)
2012
7
Recent progress in melioidosis and glanders. (22529846)
2012
8
Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. (22718333)
2012
9
Effectiveness of an antimicrobial treatment scheme in a confined glanders outbreak. (23134717)
2012
10
Humoral immune responses in a human case of glanders. (22398248)
2012
11
Diagnostic assays for glanders. (22184353)
2011
12
Glanders in donkeys (Equus Asinus) in the state of pernambuco, Brazil: A case report. (24031474)
2010
13
Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. (17362501)
2007
14
Burkholderia mallei and Burkholderia pseudomallei: the causative micro-organisms of glanders and melioidosis. (18221181)
2007
15
Comparative evaluation of Rose Bengal plate agglutination test, mallein test, and some conventional serological tests for diagnosis of equine glanders. (17609344)
2007
16
Killed in action: microbiologists and clinicians as victims of their occupation. Part 4: Tick-borne Relapsing Fever, Malta Fever, Glanders, SARS. (16423683)
2006
17
Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice. (15734072)
2005
18
Bioterrorism, Glanders and melioidosis. (15827368)
2005
19
Bichat guidelines for the clinical management of glanders and melioidosis and bioterrorism-related glanders and melioidosis. (15677841)
2004
20
Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. (12734250)
2003
21
Other bacterial diseases as a potential consequence of bioterrorism: Q fever, brucellosis, glanders, and melioidosis. (12833721)
2003
22
The eradication of glanders in Canada. (12240535)
2002
23
Serodiagnosis of equine piroplasmosis, dourine, and glanders using an arrayed immunoblotting method. (10353365)
1999
24
The great glanders epizootic, 1861-1866: a Civil War legacy. (11639801)
1995
25
Early methods for the surveillance and control of glanders in Europe. (8038452)
1994
26
History of glanders and early veterinary medicine. (17422155)
1982
27
Glanders: medicine and veterinary medicine in common pursuit of a contagious disease. (7038356)
1981
28
Pathology of glanders in horses in Iraq. (695232)
1978
29
Serological diagnosis of glanders by haemagglutination test. (5949908)
1966
30
Chronic glanders, allergic granulomatosis, or pemphigus vegetans. (14420981)
1959
31
Co-existent chronic glanders and multiple cystic osseous tuberculosis treated with streptomycin. (18110739)
1949
32
Experimental chemotherapy in glanders and melioidosis. (18908915)
1948
33
Mixed infection of glanders and epizootic lymphangitis in a horse. (20251209)
1947
34
The conglutination phenomenon; the conglutinating complement absorption test in experimental glanders. (18910337)
1947
35
Glanders in the ass. (21013331)
1945
36
Chronic Glanders. (20320183)
1936
37
DISCUSSION ON GLANDERS AND KINDRED DISEASES. (19987033)
1929
38
An Account of a Glanders-like Disease occurring in Rangoon. (20474526)
1913
39
Chronic Glanders in a Man aged 24. (19974336)
1910
40
GLANDERS IN THE HUMAN SUBJECT: CLINICAL REPORT OF TWO CASES OBSERVED IN THE FOURTH MEDICAL DIVISION OF BELLEVUE HOSPITAL OF NEW YORK. (17861945)
1907
41
The Agglutination Method of Diagnosis in the Control of Glanders. (19601345)
1906
42
VII. Pyaemic Glanders in the Human Subject. Report of a Recent Case of Laboratory Origin terminating in Recovery. (17861483)
1904
43
A Case of Septicemic Glanders in the Human Subject. (19971532)
1903
44
Methods of Diagnosis in Glanders. (19601017)
1901
45
Glanders. (19599772)
1901
46
THE USE OF TUBERCULIN AND MALLEIN FOR THE DIAGNOSIS OF TUBERCULOSIS AND GLANDERS IN ANIMALS. (17730459)
1893
47
The Glanders or Farcy Order of 1892. (20753876)
1892
48
II. On the Present State of Knowledge in Bacterial Science in its Surgical Relations (Concluded): Actinomycosis-Anthrax-Glanders. (17856094)
1886
49
A Case of Glanders in the Human Subject. (21379272)
1843
50
Additional Facts respecting Glanders in the Human Subject. (20895601)
1833

Genetic Variations for Glanders

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Expression for genes affiliated with Glanders

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glanders

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Pathways for genes affiliated with Glanders

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Glanders

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Glanders according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aclacinomycin4410.4NFE2, GATA1
2inositol 1,3,4,5-tetrakisphosphate44 1111.3INPP5J, OCRL
3gestodene44 1111.3PAEP, CYP3A5
4porphobilinogen44 11 2412.2GATA1, NFE2
5aspartate4410.0CASP14, GATA1, DPP7, RETN, ENPEP
6lipid449.9OCRL, CD58, CYP3A5, RETN, INPP5J, GPX4
7retinoic acid44 2410.9CASP14, GATA1, ITGA3, CD58, CYP3A5, PAEP
8inositol449.9INPP5E, INPP5J, OCRL

GO Terms for genes affiliated with Glanders

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16Gene Ontology
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Biological processes related to Glanders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:03516210.3GATA1, KLF1
2phosphatidylinositol dephosphorylationGO:04685610.3OCRL, INPP5J, INPP5E
3phosphatidylinositol biosynthetic processGO:00666110.2INPP5E, INPP5J, OCRL
4phospholipid metabolic processGO:00664410.1PLA2G2D, GPX4, INPP5E, INPP5J, OCRL
5negative regulation of bone mineralizationGO:03050210.0NFE2, GATA1
6small molecule metabolic processGO:0442819.7OCRL, IMPDH2, CYP3A5, INPP5J, INPP5E, GPX4

Molecular functions related to Glanders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol-polyphosphate 5-phosphatase activityGO:00444510.3INPP5E, INPP5J
2phosphatidylinositol-4,5-bisphosphate 5-phosphatase activityGO:00443910.0INPP5E, OCRL

Products for genes affiliated with Glanders

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glanders

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet