MCID: GLN002
MIFTS: 41

Glanders

Categories: Rare diseases, Infectious diseases, Endocrine diseases

Aliases & Classifications for Glanders

MalaCards integrated aliases for Glanders:

Name: Glanders 12 49 3 41 14 69
Infection Due to Pseudomonas Mallei 12
Burkholderia Mallei Infection 49
Burkholderia Mallei 49
Farcy Pipes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13444
ICD10 32 A24.0
ICD9CM 34 024
MeSH 41 D005896
NCIt 46 C34638
SNOMED-CT 64 35322000 4639008
UMLS 69 C0017589

Summaries for Glanders

Disease Ontology : 12 A primary bacterial infectious disease that results_in septicemic infection, has material basis in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards based summary : Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and aging, and has symptoms including fever, chills and sweating. An important gene associated with Glanders is KRT3 (Keratin 3), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Melphalan and Menthol have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes, and related phenotype is liver/biliary system.

CDC : 3 LocationLearn where glanders is found around the world.

Wikipedia : 72 Glanders (from Middle English glaundres or Old French glandres, both meaning glands;Latin: malleus,... more...

Related Diseases for Glanders

Diseases related to Glanders via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 melioidosis 11.0
2 aging 10.0
3 mycobacterium tuberculosis 1 10.0
4 campylobacteriosis 9.8 HCFC1 TLR4
5 blood group, i system 9.8
6 brucellosis 9.8
7 q fever 9.8
8 relapsing fever 9.8
9 tick-borne relapsing fever 9.8
10 actinomycosis 9.8
11 pemphigus 9.8
12 lymphangitis 9.8
13 pemphigus vegetans 9.8
14 bone fracture 9.7 LRP5 TLR4
15 niemann-pick disease 9.4 PSAP TLR4

Graphical network of the top 20 diseases related to Glanders:



Diseases related to Glanders

Symptoms & Phenotypes for Glanders

Symptoms:

12
  • fever
  • chills
  • sweating
  • muscle aches
  • chest pain
  • muscle tightness
  • headache
  • mucopurulent nasal discharge
  • nodular lesions in the lungs

MGI Mouse Phenotypes related to Glanders:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 HCFC1 LRP5 PSAP TLR4

Drugs & Therapeutics for Glanders

Drugs for Glanders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 460612 4053
2
Menthol Approved Phase 1 2216-51-5 16666
3 Anesthetics Phase 1
4 Alkylating Agents Phase 1
5 Immunosuppressive Agents Phase 1
6
Chloroprocaine Approved 133-16-4 8612
7
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
8
Imidacloprid Vet_approved 105827-78-9 86418
9 Anesthetics, Local
10 Central Nervous System Depressants
11 Peripheral Nervous System Agents
12 Analgesics
13 Analgesics, Non-Narcotic
14 Anti-Inflammatory Agents
15 Anti-Inflammatory Agents, Non-Steroidal
16 Antirheumatic Agents

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Glaucoma Treatment by Cyclo-coagulation Using High Intensity Focused Ultrasound (HIFU) Completed NCT01592955 Phase 4
2 Spinal Magnetic Stimulation in Neuropathic Pain Completed NCT00443469 Phase 3
3 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
4 Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases Recruiting NCT03028337 Phase 2
5 Trial for Salvage Re-Irradiation of Metastatic Spine Lesions Using Single-Fraction Stereotactic Radiosurgery Recruiting NCT02278744 Phase 1
6 Intra-arterial Chemotherapy for Spinal Metastases Recruiting NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
7 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056
8 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328
9 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
10 The Effect of Spinal Flexion in the Lateral Decubitus Position on the Unilaterality During Spinal Anesthesia Completed NCT01321684
11 Glaucoma Treatment by Circular Cyclocoagulation Using High Intensity Focused Ultrasound With the EYEOP Medical Device Completed NCT01338467
12 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
13 Characteristics of Back Pain Callers Completed NCT03474068
14 BLB Study Back or Leg Pain and Bladder Symptoms Study Recruiting NCT03325374
15 Implementation of a "Remission" Consultation in the Management of Patients Treated for Localized Breast Cancer Recruiting NCT02740491
16 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Not yet recruiting NCT02806167

Search NIH Clinical Center for Glanders

Cochrane evidence based reviews: glanders

Genetic Tests for Glanders

Anatomical Context for Glanders

MalaCards organs/tissues related to Glanders:

38
Lung, Eye, Testes, Spleen, Bone, Liver

Publications for Glanders

Articles related to Glanders:

(show top 50) (show all 141)
# Title Authors Year
1
Use of Immunohistochemistry to Demonstrate In Vivo Expression of the Burkholderia mallei Virulence Factor BpaB During Experimental Glanders. ( 29145795 )
2018
2
Outer Membrane Vesicle Vaccines from Biosafe Surrogates Prevent Acute Lethal Glanders in Mice. ( 29320408 )
2018
3
A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates. ( 29232837 )
2017
4
Identification of a new diagnostic antigen for glanders using immunoproteome analysis. ( 28750864 )
2017
5
Vaccines for the Prevention of Melioidosis and Glanders. ( 29242769 )
2017
6
Glanders And Melioidosis ( 28846298 )
2017
7
Seroprevalence and risk factors of glanders in working equines - Findings of a cross-sectional study in Punjab province of Pakistan. ( 28760480 )
2017
8
Glanders and history. ( 27339929 )
2016
9
Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches. ( 27010618 )
2016
10
Glanders and the risk for its introduction through the international movement of horses. ( 27288893 )
2016
11
Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders. ( 27271739 )
2016
12
Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice. ( 26955620 )
2016
13
Harmonising diagnostic testing for glanders in equids. ( 27313253 )
2016
14
Interlaboratory ring trial to evaluate CFT proficiency of European laboratories for diagnosis of glanders in equines. ( 27122499 )
2016
15
Surveillance focus: glanders. ( 26183359 )
2015
16
From glanders to globulins: A study in comparative medicine. ( 26307410 )
2015
17
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders. ( 26148026 )
2015
18
Pathological findings and diagnostic implications of a rhesus macaque (Macacca mulatta) model of aerosol-exposure to Burkholderia mallei (glanders). ( 25850696 )
2015
19
Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. ( 25533326 )
2015
20
Efficacy of Postexposure Therapy against Glanders in Mice. ( 25645854 )
2015
21
Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus). ( 25477002 )
2014
22
Effect of incubation temperature on the diagnostic sensitivity of the glanders complement fixation test. ( 25812210 )
2014
23
Genotyping of Burkholderia mallei from an outbreak of glanders in Bahrain suggests multiple introduction events. ( 25255232 )
2014
24
Optimization and validation of indirect ELISA using truncated TssB protein for the serodiagnosis of glanders amongst equines. ( 24672321 )
2014
25
Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. ( 23517714 )
2013
26
Assessment of the effectiveness of the PPD-mallein produced in Brazil for diagnosing glanders in mules. ( 24159303 )
2013
27
Glanders in animals: a review on epidemiology, clinical presentation, diagnosis and countermeasures. ( 22630609 )
2013
28
Glanders: an overview of infection in humans. ( 24004906 )
2013
29
From glanders to Hendra virus: 125 years of equine infectious diseases. ( 23997164 )
2013
30
Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. ( 22515029 )
2012
31
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. ( 22360070 )
2012
32
Recent progress in melioidosis and glanders. ( 22529846 )
2012
33
Humoral immune responses in a human case of glanders. ( 22398248 )
2012
34
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders. ( 23205347 )
2012
35
Development and validation of a method for purification of mallein for the diagnosis of glanders in equines. ( 22937975 )
2012
36
Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. ( 22718333 )
2012
37
Glanders outbreak at Tehran Zoo, Iran. ( 22783454 )
2012
38
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. ( 22912938 )
2012
39
Evaluation of recombinant proteins of Burkholderia mallei for serodiagnosis of glanders. ( 22695165 )
2012
40
Effectiveness of an antimicrobial treatment scheme in a confined glanders outbreak. ( 23134717 )
2012
41
Protective antigens against glanders identified by expression library immunization. ( 22125550 )
2011
42
Diagnostic assays for glanders. ( 22184353 )
2011
43
Use of a Western blot technique for the serodiagnosis of glanders. ( 21247488 )
2011
44
Comparative evaluation of three commercially available complement fixation test antigens for the diagnosis of glanders. ( 21896565 )
2011
45
Use of a recombinant burkholderia intracellular motility a protein for immunodiagnosis of glanders. ( 21752949 )
2011
46
Present and future therapeutic strategies for melioidosis and glanders. ( 20192686 )
2010
47
Glanders in donkeys (Equus Asinus) in the state of pernambuco, Brazil: A case report. ( 24031474 )
2010
48
Re-emergence of glanders in India - Report of Maharashtra state. ( 23100851 )
2010
49
Molecular epidemiology of glanders, Pakistan. ( 19961695 )
2009
50
Prevalence-dependent use of serological tests for diagnosing glanders in horses. ( 19723336 )
2009

Variations for Glanders

Expression for Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for Glanders

Pathways related to Glanders according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.17 LRP5 TLR4
2 10.49 LRP5 TLR4

GO Terms for Glanders

Cellular components related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.62 LRP5 TLR4

Biological processes related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 8.8 HCFC1 LRP5 TLR4

Sources for Glanders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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