MCID: GLS012
MIFTS: 29

Glassy Cell Carcinoma of the Cervix malady

Cancer diseases category

Summaries for Glassy Cell Carcinoma of the Cervix

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63Wikipedia, 32MalaCards
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Wikipedia:63 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

MalaCards: Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to glassy cell carcinoma of the cervix uteri and uterine sarcoma. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (progesterone receptor), and among its related pathways are Nuclear Receptor transcription pathway and Cell cycle Cell cycle (generic schema). The compounds ici 164384 and Ethynodiol Diacetate have been mentioned in the context of this disorder. Affiliated tissues include cervix, and related mouse phenotypes are muscle and limbs/digits/tail.

Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

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42NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

glassy cell carcinoma of the cervix 42
glassy cell adenocarcinoma of the uterine cervix 42
gcc of the cervix 42


Related Diseases for Glassy Cell Carcinoma of the Cervix

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17GeneCards, 18GeneDecks
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Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1glassy cell carcinoma of the cervix uteri10.5
2uterine sarcoma10.0ESR1
3cerebral meningioma10.0PGR
4sertoli-leydig cell tumor10.0PGR
5osteosarcoma10.0ESR1
6uterine carcinosarcoma10.0ERBB2
7pituitary tumors10.0ESR1
8fibromatosis10.0PGR
9prolactinoma10.0ESR1
10bilateral breast cancer10.0ESR1, PGR
11gynecomastia10.0ESR1, PGR
12cervical adenocarcinoma10.0ESR1, PGR
13progesterone resistance10.0PGR, ESR1
14cribriform carcinoma10.0PGR, ESR1
15adenosarcoma10.0ESR1, PGR
16endometrial stromal sarcoma10.0ESR1, PGR
17leiomyoma10.0ESR1, PGR
18leiomyomatosis10.0ESR1, PGR
19myoma10.0ESR1, PGR
20endometriosis10.0PGR, ESR1
21smooth muscle tumor10.0PGR, ESR1
22leiomyosarcoma10.0PGR
23lymphangioleiomyomatosis10.0ESR1, PGR
24meningioma10.0ESR1, PGR
25angiomyolipoma10.0ESR1, PGR
26factor vii deficiency10.0ERBB2, ESR1
27uterine fibroid10.0PGR, ESR1
28malignant mixed mullerian tumor10.0ERBB2, PGR
29retinoblastoma10.0ERBB2, ESR1
30mammary paget's disease10.0PGR, ERBB2, ESR1
31male breast cancer10.0PGR, ERBB2, ESR1
32inflammatory breast carcinoma10.0ESR1, ERBB2, PGR
33breast cancer, invasive ductal10.0PGR, ERBB2, ESR1
34tubular adenocarcinoma10.0ESR1, ERBB2, PGR
35breast fibroadenoma10.0ESR1, ERBB2, PGR
36papillary carcinoma10.0ESR1, ERBB2, PGR
37li-fraumeni syndrome10.0ESR1, ERBB2, PGR
38ductal carcinoma in situ10.0ESR1, ERBB2, PGR
39ovarian cancer10.0PGR, ERBB2, ESR1
40endometrial carcinoma10.0ESR1, ERBB2, PGR
41breast cancer10.0ESR1, ERBB2, PGR

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to glassy cell carcinoma of the cervix

Clinical Features for Glassy Cell Carcinoma of the Cervix

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Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glassy Cell Carcinoma of the Cervix

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Anatomical Context for Glassy Cell Carcinoma of the Cervix

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32MalaCards
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MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

32
Cervix

Animal Models for Glassy Cell Carcinoma of the Cervix or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0ESR1
2MP:00053718.6ESR1, ERBB2, PGR
3MP:00020068.6ESR1, ERBB2, PGR
4MP:00107718.5ESR1, ERBB2, PGR
5MP:00053798.4PGR, ERBB2, ESR1
6MP:00053908.2ESR1, ERBB2, PGR

Publications for Glassy Cell Carcinoma of the Cervix

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Genetic Variations for Glassy Cell Carcinoma of the Cervix

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Expression for genes affiliated with Glassy Cell Carcinoma of the Cervix

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glassy Cell Carcinoma of the Cervix

Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.

Pathways for genes affiliated with Glassy Cell Carcinoma of the Cervix

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.3ESR1, PGR
2
Cell cycle Cell cycle (generic schema)
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9.3PGR, ESR1
39.1ESR1, ERBB2
4
Development Prolactin receptor signaling
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9.1ESR1, ERBB2
5
Development Ligand-independent activation of ESR1 and ESR2
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9.1ESR1, ERBB2
6
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8.5ESR1, ERBB2, PGR

Compounds for genes affiliated with Glassy Cell Carcinoma of the Cervix

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1ici 164384449.8ESR1, PGR
2Ethynodiol Diacetate119.8PGR, ESR1
3Etonogestrel119.7ESR1, PGR
4Allylestrenol119.7PGR, ESR1
5idoxifene449.7PGR, ESR1
6triphenylethylene449.7ESR1, PGR
7norgestimate44 1110.7ESR1, PGR
8medroxyprogesterone44 49 28 11 2413.7PGR, ESR1
9trilostane44 1110.7PGR, ESR1
10droloxifene449.7PGR, ESR1
11estradiol benzoate449.7PGR, ESR1
12nandrolone44 2410.7PGR, ESR1
13onapristone44 2810.7ESR1, PGR
14desogestrel44 1110.6PGR, ESR1
15goserelin44 28 1111.6PGR, ESR1
16nomegestrol acetate449.6ESR1, PGR
17leuprolide acetate449.6ESR1, PGR
18bisphenol a449.5PGR, ESR1
19fadrozole449.5ESR1, ERBB2
20clomiphene citrate449.5PGR, ESR1
21tibolone449.4PGR, ESR1
22danazol44 11 2411.3PGR, ESR1
23flutamide44 59 1111.3PGR, ESR1
24capecitabine44 49 1111.3ERBB2, PGR
25levonorgestrel44 59 28 1112.2ESR1, PGR
26megestrol acetate449.0ERBB2, PGR, ESR1
27anastrozole44 1110.0ESR1, ERBB2, PGR
28exemestane49 44 59 1112.0PGR, ERBB2, ESR1
29lapatinib44 49 1111.0PGR, ERBB2, ESR1
30toremifene44 1110.0ESR1, ERBB2, PGR
31fulvestrant44 49 28 1111.9ERBB2, PGR, ESR1
32taxane448.9ESR1, ERBB2, PGR
33letrozole44 49 59 1111.9ESR1, ERBB2, PGR
34raloxifene44 28 49 1111.9ERBB2, PGR, ESR1
35trastuzumab44 49 1110.9ESR1, ERBB2, PGR
364-hydroxytamoxifen448.9ESR1, PGR, ERBB2
37progestin448.9ESR1, ERBB2, PGR
38geldanamycin44 49 59 1111.9ESR1, PGR, ERBB2
39resveratrol44 59 11 2411.9ESR1, ERBB2, PGR
40docetaxel44 49 59 1111.9ERBB2, PGR, ESR1
41cyclophosphamide44 49 1110.9PGR, ESR1, ERBB2
42methotrexate44 49 1110.9ERBB2, ESR1, PGR
43gnrh448.9PGR, ERBB2, ESR1
445fluorouracil448.9ESR1, PGR, ERBB2
45radicicol44 59 1110.8ESR1, ERBB2
46tamoxifen44 49 28 1111.8ERBB2, ESR1, PGR
47paclitaxel44 49 1110.8ERBB2, ESR1, PGR
48doxorubicin44 49 1110.7PGR, ERBB2, ESR1
49paraffin448.7ESR1, PGR, ERBB2
50genistein44 28 59 2 11 2413.6PGR, ERBB2, ESR1

GO Terms for genes affiliated with Glassy Cell Carcinoma of the Cervix

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16Gene Ontology
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Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:0063679.3ESR1, PGR
2negative regulation of gene expressionGO:0106299.2ESR1, PGR
3signal transductionGO:0071658.2ESR1, ERBB2, PGR

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.3ESR1, PGR
2steroid bindingGO:0054969.0ESR1, PGR

Products for genes affiliated with Glassy Cell Carcinoma of the Cervix

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  • Antibodies
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Sources for Glassy Cell Carcinoma of the Cervix

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet