MCID: GLS012
MIFTS: 37

Glassy Cell Carcinoma of the Cervix malady

Rare diseases, Cancer diseases categories

Summaries for Glassy Cell Carcinoma of the Cervix

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66Wikipedia, 34MalaCards
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Wikipedia:66 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

MalaCards: Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to glassy cell carcinoma of the cervix uteri and cerebral meningioma. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (progesterone receptor), and among its related pathways are Nuclear signaling by ERBB4 and Cell cycle Regulation of G1 S transition part 2 . The compounds ici 164384 and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include cervix and ovary, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

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44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

glassy cell carcinoma of the cervix 44
glassy cell adenocarcinoma of the uterine cervix 44
gcc of the cervix 44


Related Diseases for Glassy Cell Carcinoma of the Cervix

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to glassy cell carcinoma of the cervix

Symptoms for Glassy Cell Carcinoma of the Cervix

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Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Genetic Tests for Glassy Cell Carcinoma of the Cervix

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Anatomical Context for Glassy Cell Carcinoma of the Cervix

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34MalaCards
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MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

34
Cervix, Ovary

Animal Models for Glassy Cell Carcinoma of the Cervix or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7ERBB2, ESR1, PGR
2MP:00020068.7ERBB2, ESR1, PGR
3MP:00053698.7PGR, ESR1, ERBB2
4MP:00053798.6ERBB2, ESR1, PGR
5MP:00053908.6PGR, ESR1, ERBB2
6MP:00107718.5ERBB2, ESR1, PGR
7MP:00053858.5ERBB2, ESR1, PGR
8MP:00053808.4PGR, ESR1, ERBB2
9MP:00053898.2ERBB2, ESR1, PGR

Publications for Glassy Cell Carcinoma of the Cervix

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53PubMed
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Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 18)
idTitleAuthorsYear
1
Glassy cell carcinoma of the cervix--a case report with review of the literature. (22384631)
2011
2
Conservatively treated glassy cell carcinoma of the cervix. (18755015)
2008
3
Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. (16901007)
2006
4
Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. (14969191)
2004
5
Glassy cell carcinoma of the cervix revisited. (11972387)
2002
6
Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? (12462103)
2002
7
Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. (10791384)
2000
8
Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. (9464737)
1998
9
Glassy cell carcinoma of the cervix: a bimodal treatment strategy. (1541437)
1992
10
Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. (1916516)
1991
11
Glassy cell carcinoma of the cervix redefined. (3368169)
1988
12
Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. (6861073)
1983
13
Glassy cell carcinoma of the cervix: report of three cases. (7120471)
1982
14
Glassy cell carcinoma of the cervix. (6296737)
1982
15
A clinicopathological study on glassy cell carcinoma of the cervix. (7234357)
1981
16
Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. (7233592)
1980
17
Stage i B glassy cell carcinoma of the cervix with ovarian metastases. (858556)
1977
18
Glassy cell carcinoma of the cervix. (1260713)
1976

Variations for Glassy Cell Carcinoma of the Cervix

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Expression for genes affiliated with Glassy Cell Carcinoma of the Cervix

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glassy Cell Carcinoma of the Cervix

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Pathways for genes affiliated with Glassy Cell Carcinoma of the Cervix

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51PathCards, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3ESR1, PGR
2
Show member pathways
Cell cycle ESR1 regulation of G1 S transition61
Immune response MIF JAB1 signaling61
Cell cycle Cell cycle generic schema 61
9.3ESR1, PGR
3
Show member pathways
Nuclear Receptors39
9.3PGR, ESR1
4
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.1ERBB2, ESR1
59.1ERBB2, ESR1
69.1ERBB2, ESR1
7
Show member pathways
Development Ligand independent activation of ESR1 and ESR261
9.1ERBB2, ESR1
8
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.1ESR1, ERBB2
9
Show member pathways
8.5ERBB2, ESR1, PGR
10
Show member pathways
8.5PGR, ESR1, ERBB2

Compounds for genes affiliated with Glassy Cell Carcinoma of the Cervix

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46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1ici 164384469.8PGR, ESR1
2idoxifene469.7ESR1, PGR
3triphenylethylene469.7PGR, ESR1
4norgestimate46 1210.7PGR, ESR1
5medroxyprogesterone46 52 30 25 1213.7ESR1, PGR
6trilostane46 1210.7ESR1, PGR
7droloxifene469.7ESR1, PGR
8estradiol benzoate469.7PGR, ESR1
9nandrolone46 2510.7PGR, ESR1
10desogestrel46 1210.7PGR, ESR1
11onapristone46 3010.7PGR, ESR1
12goserelin46 30 1211.7PGR, ESR1
13nomegestrol acetate469.6PGR, ESR1
14leuprolide acetate469.6PGR, ESR1
15bisphenol a469.6PGR, ESR1
16fadrozole469.5ESR1, ERBB2
17clomiphene citrate469.5ESR1, PGR
18tibolone469.5PGR, ESR1
19danazol46 25 1211.4PGR, ESR1
20levonorgestrel46 62 30 1212.4PGR, ESR1
21everolimus46 52 1211.3ESR1, ERBB2
22steroidal469.3ESR1, PGR
23capecitabine46 52 1211.3ERBB2, PGR
24flutamide46 62 1211.2PGR, ESR1
25megestrol acetate469.0ERBB2, ESR1, PGR
26exemestane46 52 62 1212.0ESR1, PGR, ERBB2
27anastrozole46 52 1211.0ERBB2, PGR, ESR1
28lapatinib46 52 1211.0ESR1, PGR, ERBB2
29toremifene46 1210.0ERBB2, PGR, ESR1
30fulvestrant46 52 30 1211.9ESR1, ERBB2, PGR
31letrozole46 52 62 1211.9ESR1, ERBB2, PGR
32taxane468.9ESR1, ERBB2, PGR
33raloxifene46 52 30 1211.9PGR, ERBB2, ESR1
34trastuzumab46 52 1210.9ERBB2, PGR, ESR1
354-hydroxytamoxifen468.9PGR, ESR1, ERBB2
36progestin468.9ERBB2, PGR, ESR1
37geldanamycin46 52 62 1211.9PGR, ESR1, ERBB2
38resveratrol46 62 25 1211.9PGR, ESR1, ERBB2
39docetaxel46 52 62 1211.9ERBB2, ESR1, PGR
40cyclophosphamide46 52 1210.9PGR, ERBB2, ESR1
41gnrh468.9PGR, ESR1, ERBB2
42methotrexate52 46 1210.9ERBB2, ESR1, PGR
435fluorouracil468.9ERBB2, ESR1, PGR
44tamoxifen46 52 30 1211.9ERBB2, ESR1, PGR
45radicicol46 62 1210.8ERBB2, ESR1
46paclitaxel46 52 1210.8ERBB2, PGR, ESR1
47doxorubicin46 52 1210.8ERBB2, PGR, ESR1
48paraffin468.8ERBB2, ESR1, PGR
49genistein46 30 62 3 25 1213.7ESR1, ERBB2, PGR
50cycloheximide468.5PGR, ERBB2, ESR1

GO Terms for genes affiliated with Glassy Cell Carcinoma of the Cervix

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17Gene Ontology
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Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:0063679.3ESR1, PGR
2negative regulation of gene expressionGO:0106299.2ESR1, PGR
3signal transductionGO:0071658.2ERBB2, ESR1, PGR

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.3ESR1, PGR
2steroid bindingGO:0054969.2ESR1, PGR
3steroid hormone receptor activityGO:0037079.0ESR1, PGR

Products for genes affiliated with Glassy Cell Carcinoma of the Cervix

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Sources for Glassy Cell Carcinoma of the Cervix

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet