MCID: GLS012
MIFTS: 29

Glassy Cell Carcinoma of the Cervix

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

MalaCards integrated aliases for Glassy Cell Carcinoma of the Cervix:

Name: Glassy Cell Carcinoma of the Cervix 49
Glassy Cell Adenocarcinoma of the Uterine Cervix 49
Gcc of the Cervix 49

Classifications:



Summaries for Glassy Cell Carcinoma of the Cervix

MalaCards based summary : Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to glassy cell carcinoma of the cervix uteri and vulvar syringoma. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include cervix and ovary, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 72 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

Related Diseases for Glassy Cell Carcinoma of the Cervix

Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 glassy cell carcinoma of the cervix uteri 12.3
2 vulvar syringoma 10.1 ESR1 PGR
3 vestibular gland benign neoplasm 10.1 ESR1 PGR
4 lung leiomyoma 10.1 ESR1 PGR
5 bartholin's gland adenoma 10.1 ESR1 PGR
6 vulvar benign neoplasm 10.1 ESR1 PGR
7 trigonitis 10.1 ESR1 PGR
8 vulvar leiomyoma 10.1 ESR1 PGR
9 predominantly cortical thymoma 10.1 ESR1 PGR
10 progesterone resistance 10.1 ESR1 PGR
11 cribriform carcinoma 10.1 ESR1 PGR
12 bartholin's gland benign neoplasm 10.1 ESR1 PGR
13 endometrial squamous cell carcinoma 10.1 ESR1 PGR
14 gastric signet ring cell adenocarcinoma 10.1 ESR1 PGR
15 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
16 adenoid basal cell carcinoma 10.1 ESR1 PGR
17 deep angioma 10.1 ESR1 PGR
18 gender identity disorder 10.1 ESR1 PGR
19 cervical carcinosarcoma 10.1 ESR1 PGR
20 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
21 intramuscular hemangioma 10.1 ESR1 PGR
22 estrogen excess 10.1 ESR1 PGR
23 glycogen-rich clear cell breast carcinoma 10.1 ESR1 PGR
24 mammographic density 10.1 ESR1 PGR
25 retinitis pigmentosa 47 10.1 ESR1 PGR
26 adenomyosis 10.0 ESR1 PGR
27 retinitis pigmentosa 20 10.0 ESR1 PGR
28 adenosarcoma 10.0 ESR1 PGR
29 cervical clear cell adenocarcinoma 10.0 ESR1 PGR
30 surfactant metabolism dysfunction, pulmonary, 1 10.0
31 surfactant metabolism dysfunction, pulmonary, 4 10.0
32 surfactant metabolism dysfunction, pulmonary, 3 10.0
33 endometriosis of ovary 10.0 ESR1 PGR
34 reproductive organ benign neoplasm 10.0 ESR1 PGR
35 uterine benign neoplasm 10.0 ESR1 PGR
36 peritoneal mesothelioma 10.0 ESR1 PGR
37 smooth muscle tumor 10.0 ESR1 PGR
38 pancreatic mucinous cystadenoma 10.0 ESR1 PGR
39 endometritis 10.0 ESR1 PGR
40 prostatic hypertrophy 10.0 ESR1 PGR
41 juvenile nasopharyngeal angiofibroma 10.0 ESR1 PGR
42 angiomyolipoma 10.0 ESR1 PGR
43 leiomyomatosis 10.0 ESR1 PGR
44 gynecomastia 10.0 ESR1 PGR
45 leiomyoma, uterine 9.9 ESR1 PGR
46 comedo carcinoma 9.9 ERBB2 ESR1
47 female reproductive system disease 9.9 ESR1 PGR
48 myoma 9.9 ESR1 PGR
49 reproductive system disease 9.9 ESR1 PGR
50 lobular neoplasia 9.9 ERBB2 ESR1

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to Glassy Cell Carcinoma of the Cervix

Symptoms & Phenotypes for Glassy Cell Carcinoma of the Cervix

MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.33 ERBB2 ESR1 PGR
2 muscle MP:0005369 9.13 ERBB2 ESR1 PGR
3 neoplasm MP:0002006 8.8 ERBB2 ESR1 PGR

Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

Search Clinical Trials , NIH Clinical Center for Glassy Cell Carcinoma of the Cervix

Genetic Tests for Glassy Cell Carcinoma of the Cervix

Anatomical Context for Glassy Cell Carcinoma of the Cervix

MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

38
Cervix, Ovary

Publications for Glassy Cell Carcinoma of the Cervix

Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 22)
# Title Authors Year
1
Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. ( 26974246 )
2016
2
Glassy Cell Carcinoma of the Cervix and Metastasis in Episiotomy Scar: A Case Report. ( 25062402 )
2014
3
Glassy cell carcinoma of the cervix: a literature review. ( 24792540 )
2014
4
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis. ( 24503463 )
2014
5
Glassy cell carcinoma of the cervix--a case report with review of the literature. ( 22384631 )
2011
6
Conservatively treated glassy cell carcinoma of the cervix. ( 18755015 )
2008
7
Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. ( 16901007 )
2006
8
Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. ( 14969191 )
2004
9
Glassy cell carcinoma of the cervix revisited. ( 11972387 )
2002
10
Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? ( 12462103 )
2002
11
Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. ( 10791384 )
2000
12
Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. ( 9464737 )
1998
13
Glassy cell carcinoma of the cervix: a bimodal treatment strategy. ( 1541437 )
1992
14
Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. ( 1916516 )
1991
15
Glassy cell carcinoma of the cervix redefined. ( 3368169 )
1988
16
Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. ( 6861073 )
1983
17
Glassy cell carcinoma of the cervix: report of three cases. ( 7120471 )
1982
18
Glassy cell carcinoma of the cervix. ( 6296737 )
1982
19
A clinicopathological study on glassy cell carcinoma of the cervix. ( 7234357 )
1981
20
Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. ( 7233592 )
1980
21
Stage i B glassy cell carcinoma of the cervix with ovarian metastases. ( 858556 )
1977
22
Glassy cell carcinoma of the cervix. ( 1260713 )
1976

Variations for Glassy Cell Carcinoma of the Cervix

Cosmic variations for Glassy Cell Carcinoma of the Cervix:

9 (show all 46)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10656 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 15
2 COSM44399 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 15
3 COSM10725 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 15
4 COSM10662 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 15
5 COSM11333 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 15
6 COSM29468 STK11 cervix,NS,carcinoma,adenocarcinoma c.910C>T p.R304W 15
7 COSM29467 STK11 cervix,NS,carcinoma,adenocarcinoma c.894C>A p.F298L 15
8 COSM88109 PTEN cervix,NS,carcinoma,adenocarcinoma c.724G>T p.E242* 15
9 COSM5154 PTEN cervix,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 15
10 COSM5219 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>G p.R130G 15
11 COSM5056 PTEN cervix,NS,carcinoma,adenocarcinoma c.1093G>A p.V365I 15
12 COSM5152 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>T p.R130* 15
13 COSM775 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 15
14 COSM763 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 15
15 COSM12584 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1357G>A p.E453K 15
16 COSM29313 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3129G>A p.M1043I 15
17 COSM746 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 15
18 COSM27133 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>C p.E545Q 15
19 COSM6147 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1636C>G p.Q546E 15
20 COSM760 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 15
21 COSM24712 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1638G>T p.Q546H 15
22 COSM759 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1616C>G p.P539R 15
23 COSM584 NRAS cervix,NS,carcinoma,adenocarcinoma c.182A>G p.Q61R 15
24 COSM521 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 15
25 COSM517 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 15
26 COSM555 KRAS cervix,NS,carcinoma,adenocarcinoma c.183A>T p.Q61H 15
27 COSM522 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 15
28 COSM518 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>C p.G12R 15
29 COSM532 KRAS cervix,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 15
30 COSM516 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 15
31 COSM520 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 15
32 COSM551 KRAS cervix,NS,carcinoma,adenocarcinoma c.182A>C p.Q61P 15
33 COSM480 HRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 15
34 COSM5945795 GNA11 cervix,NS,carcinoma,adenocarcinoma c.972C>G p.I324M 15
35 COSM22975 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1513C>T p.R505C 15
36 COSM420169 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1436G>C p.R479P 15
37 COSM94225 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>A p.S310Y 15
38 COSM48358 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>T p.S310F 15
39 COSM5662 CTNNB1 cervix,NS,carcinoma,adenocarcinoma c.110C>T p.S37F 15
40 COSM5683 CTNNB1 cervix,NS,carcinoma,adenocarcinoma c.97T>G p.S33A 15
41 COSM451 BRAF cervix,NS,carcinoma,adenocarcinoma c.1397G>T p.G466V 15
42 COSM461 BRAF cervix,NS,carcinoma,adenocarcinoma c.1406G>A p.G469E 15
43 COSM470 BRAF cervix,NS,carcinoma,adenocarcinoma c.1789C>G p.L597V 15
44 COSM26506 BRAF cervix,NS,carcinoma,adenocarcinoma c.1787G>A p.G596D 15
45 COSM5945792 ATM cervix,NS,carcinoma,adenocarcinoma c.7322T>G p.V2441G 15
46 COSM5369888 ALK cervix,NS,carcinoma,adenocarcinoma c.1396G>A p.D466N 15

Expression for Glassy Cell Carcinoma of the Cervix

Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.

Pathways for Glassy Cell Carcinoma of the Cervix

Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 ERBB2 ESR1 PGR
2
Show member pathways
11.73 ERBB2 ESR1
3 11.68 ERBB2 ESR1
4
Show member pathways
11.57 ESR1 PGR
5
Show member pathways
11.23 ERBB2 ESR1
6
Show member pathways
11.11 ESR1 PGR
7
Show member pathways
10.83 ERBB2 ESR1 PGR

GO Terms for Glassy Cell Carcinoma of the Cervix

Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.16 ESR1 PGR
2 transcription initiation from RNA polymerase II promoter GO:0006367 8.96 ESR1 PGR
3 steroid hormone mediated signaling pathway GO:0043401 8.62 ESR1 PGR

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ERBB2 ESR1 PGR
2 ATPase binding GO:0051117 9.26 ESR1 PGR
3 steroid hormone receptor activity GO:0003707 9.16 ESR1 PGR
4 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
5 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Glassy Cell Carcinoma of the Cervix

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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41 MeSH
42 MESH via Orphanet
43 MGI
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50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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