MCID: GLS012
MIFTS: 23

Glassy Cell Carcinoma of the Cervix malady

Cancer category

Summaries for Glassy Cell Carcinoma of the Cervix

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64Wikipedia, 33MalaCards
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Wikipedia:64 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

MalaCards: Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to glassy cell carcinoma of the cervix uteri and uterine sarcoma. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (progesterone receptor), and among its related pathways are Nuclear Receptor transcription pathway and Cell cycle Cell cycle (generic schema). The compounds Ethynodiol Diacetate and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include cervix, and related mouse phenotypes are muscle and limbs/digits/tail.

Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

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43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

glassy cell carcinoma of the cervix 43
glassy cell adenocarcinoma of the uterine cervix 43
gcc of the cervix 43


Related Diseases for Glassy Cell Carcinoma of the Cervix

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17GeneCards, 18GeneDecks
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Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1glassy cell carcinoma of the cervix uteri10.6
2uterine sarcoma10.0ESR1
3cerebral meningioma10.0PGR
4sertoli-leydig cell tumor10.0PGR
5osteosarcoma10.0ESR1
6uterine carcinosarcoma10.0ERBB2
7pituitary tumors10.0ESR1
8fibromatosis10.0PGR
9prolactinoma10.0ESR1
10bilateral breast cancer10.0ESR1, PGR
11gynecomastia10.0ESR1, PGR
12cervical adenocarcinoma10.0ESR1, PGR
13progesterone resistance10.0PGR, ESR1
14cribriform carcinoma10.0PGR, ESR1
15adenosarcoma10.0ESR1, PGR
16endometrial stromal sarcoma10.0ESR1, PGR
17leiomyoma10.0ESR1, PGR
18leiomyomatosis10.0ESR1, PGR
19myoma10.0ESR1, PGR
20endometriosis10.0PGR, ESR1
21smooth muscle tumor10.0PGR, ESR1
22leiomyosarcoma10.0PGR
23lymphangioleiomyomatosis10.0ESR1, PGR
24meningioma10.0ESR1, PGR
25angiomyolipoma10.0ESR1, PGR
26factor vii deficiency10.0ERBB2, ESR1
27uterine fibroid10.0PGR, ESR1
28malignant mixed mullerian tumor10.0ERBB2, PGR
29retinoblastoma10.0ERBB2, ESR1
30mammary paget's disease10.0PGR, ERBB2, ESR1
31male breast cancer10.0PGR, ERBB2, ESR1
32inflammatory breast carcinoma10.0ESR1, ERBB2, PGR
33breast cancer, invasive ductal10.0PGR, ERBB2, ESR1
34tubular adenocarcinoma10.0ESR1, ERBB2, PGR
35breast fibroadenoma10.0ESR1, ERBB2, PGR
36papillary carcinoma10.0ESR1, ERBB2, PGR
37li-fraumeni syndrome10.0ESR1, ERBB2, PGR
38ductal carcinoma in situ10.0ESR1, ERBB2, PGR
39ovarian cancer10.0PGR, ERBB2, ESR1
40endometrial carcinoma10.0ESR1, ERBB2, PGR
41breast cancer10.0ESR1, ERBB2, PGR

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to glassy cell carcinoma of the cervix

Clinical Features for Glassy Cell Carcinoma of the Cervix

Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glassy Cell Carcinoma of the Cervix

Anatomical Context for Glassy Cell Carcinoma of the Cervix

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33MalaCards
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MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

33
Cervix

Animal Models for Glassy Cell Carcinoma of the Cervix or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0ESR1
2MP:00053718.6ESR1, ERBB2, PGR
3MP:00020068.6ESR1, ERBB2, PGR
4MP:00107718.5ESR1, ERBB2, PGR
5MP:00053798.4PGR, ERBB2, ESR1
6MP:00053908.2ESR1, ERBB2, PGR

Publications for Glassy Cell Carcinoma of the Cervix

Genetic Variations for Glassy Cell Carcinoma of the Cervix

Expression for genes affiliated with Glassy Cell Carcinoma of the Cervix

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glassy Cell Carcinoma of the Cervix

Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.

Pathways for genes affiliated with Glassy Cell Carcinoma of the Cervix

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
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Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3ESR1, PGR
2
Cell cycle Cell cycle (generic schema)
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9.3PGR, ESR1
39.1ESR1, ERBB2
4
Development Prolactin receptor signaling
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9.1ESR1, ERBB2
5
Development Ligand-independent activation of ESR1 and ESR2
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9.1ESR1, ERBB2
6
Hide members
8.5ESR1, ERBB2, PGR

Compounds for genes affiliated with Glassy Cell Carcinoma of the Cervix

Sources:
11DrugBank, 45Novoseek, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1Ethynodiol Diacetate119.8PGR, ESR1
2ici 164384459.8PGR, ESR1
3idoxifene459.7ESR1, PGR
4Etonogestrel119.7ESR1, PGR
5Allylestrenol119.7ESR1, PGR
6triphenylethylene459.7ESR1, PGR
7norgestimate45 1110.7PGR, ESR1
8medroxyprogesterone45 50 29 11 2413.7ESR1, PGR
9trilostane45 1110.7ESR1, PGR
10estradiol benzoate459.7PGR, ESR1
11nandrolone45 2410.7PGR, ESR1
12droloxifene459.7PGR, ESR1
13onapristone45 2910.7PGR, ESR1
14desogestrel45 1110.6PGR, ESR1
15goserelin45 29 1111.6ESR1, PGR
16nomegestrol acetate459.6ESR1, PGR
17leuprolide acetate459.6ESR1, PGR
18bisphenol a459.5ESR1, PGR
19fadrozole459.5ESR1, ERBB2
20clomiphene citrate459.5ESR1, PGR
21tibolone459.4ESR1, PGR
22danazol45 11 2411.3PGR, ESR1
23flutamide45 60 1111.3ESR1, PGR
24capecitabine45 50 1111.3ERBB2, PGR
25levonorgestrel45 60 29 1112.2ESR1, PGR
26megestrol acetate459.0ESR1, ERBB2, PGR
27anastrozole45 1110.0ESR1, ERBB2, PGR
28exemestane50 45 60 1112.0PGR, ERBB2, ESR1
29lapatinib45 50 1111.0ESR1, ERBB2, PGR
30toremifene45 1110.0ESR1, ERBB2, PGR
31fulvestrant45 50 29 1111.9PGR, ERBB2, ESR1
32taxane458.9ESR1, ERBB2, PGR
33letrozole45 50 60 1111.9ESR1, ERBB2, PGR
34raloxifene45 29 50 1111.9PGR, ERBB2, ESR1
35trastuzumab45 50 1110.9ESR1, ERBB2, PGR
364-hydroxytamoxifen458.9ESR1, ERBB2, PGR
37progestin458.9PGR, ERBB2, ESR1
38geldanamycin45 50 60 1111.9PGR, ERBB2, ESR1
39resveratrol45 60 11 2411.9ESR1, ERBB2, PGR
40docetaxel45 50 60 1111.9PGR, ERBB2, ESR1
41cyclophosphamide45 50 1110.9ESR1, ERBB2, PGR
42methotrexate45 50 1110.9ESR1, ERBB2, PGR
43gnrh458.9PGR, ERBB2, ESR1
445fluorouracil458.9ESR1, ERBB2, PGR
45radicicol45 60 1110.8ESR1, ERBB2
46tamoxifen45 50 29 1111.8PGR, ERBB2, ESR1
47paclitaxel45 50 1110.8ESR1, ERBB2, PGR
48doxorubicin45 50 1110.7PGR, ERBB2, ESR1
49paraffin458.7PGR, ERBB2, ESR1
50genistein45 29 60 2 11 2413.6ESR1, ERBB2, PGR

GO Terms for genes affiliated with Glassy Cell Carcinoma of the Cervix

Sources:
16Gene Ontology
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Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:0063679.3ESR1, PGR
2negative regulation of gene expressionGO:0106299.2ESR1, PGR
3signal transductionGO:0071658.2ESR1, ERBB2, PGR

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.3ESR1, PGR
2steroid bindingGO:0054969.0ESR1, PGR

Products for genes affiliated with Glassy Cell Carcinoma of the Cervix

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glassy Cell Carcinoma of the Cervix

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet