MCID: GLC007
MIFTS: 60

Glaucoma malady

Genetic diseases, Eye diseases, Rare diseases, Fetal diseases categories

Summaries for Glaucoma

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Glaucoma is a group of diseases that can damage the eye's optic nerve. it is a leading cause of blindness in the united states. it usually happens when the fluid pressure inside the eyes slowly rises, damaging the optic nerve. often there are no symptoms at first. without treatment, people with glaucoma will slowly lose their peripheral, or side vision. they seem to be looking through a tunnel. over time, straight-ahead vision may decrease until no vision remains. a comprehensive eye exam can tell if you have glaucoma. people at risk should get eye exams at least every two years. they include african americans over age 40 people over age 60, especially mexican americans people with a family history of glaucoma there is no cure, but glaucoma can usually be controlled. early treatment can help protect your eyes against vision loss. treatments usually include prescription eyedrops and/or surgery. nih: national eye institute

MalaCards: Glaucoma is related to open-angle glaucoma and primary open angle glaucoma. An important gene associated with Glaucoma is OPTN (optineurin). The drugs acetazolamide and carbachol and the compounds parathion and coumarin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related mouse phenotype vision/eye.

Wikipedia:66 Glaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a... more...

Aliases & Classifications for Glaucoma

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Sources:
9Disease Ontology, 21GeneTests, 23GTR, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Related Diseases for Glaucoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Glaucoma family:

Juvenile Glaucoma Primary Congenital Glaucoma
Glaucoma Type 1c Glaucoma, Congenital
Glaucoma, Hereditary Glaucoma, Hereditary Adult Type 1a
Glaucoma, Hereditary Juvenile Type 1b Cyp1b1-Related Primary Congenital Glaucoma
Ltbp2-Related Primary Congenital Glaucoma Early-Onset Glaucoma
Glaucoma 3, Primary Congenital, D Glaucoma 3, Primary Congenital, C

Diseases related to Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 509)
idRelated DiseaseScoreTop Affiliating Genes
1open-angle glaucoma32.0WDR36, CYP1B1, MYOC, OPTN
2primary open angle glaucoma31.9CYP1B1, OPTN, ASB10, MYOC
3primary angle-closure glaucoma31.7MYOC
4ocular hypertension31.6OPTN, MYOC
5primary congenital glaucoma31.5CYP1B1
6blindness30.6MYOC, FOXC1, WDR36, OPTN
7primary open angle glaucoma juvenile onset 130.6CYP1B1, MYOC
8glaucoma 3, primary congenital, d30.4FOXC1, CYP1B1, OPTN, MYOC
9eye disease30.2OPTN, MYOC, FOXC1
10axenfeld-rieger syndrome30.1CYP1B1, FOXC1
11peters plus syndrome30.1FOXC1, CYP1B1
12optic nerve disease29.7MYOC, OPTN
13neovascular glaucoma11.0
14hypertension11.0
15retinitis10.9
16low tension glaucoma10.8
17cataract10.8
18juvenile glaucoma10.7
19exfoliation syndrome10.6
20sturge-weber syndrome10.6
21weber syndrome10.6
22phacolytic glaucoma10.6
23steroid-induced glaucoma10.6
24aniridia10.5
25endotheliitis10.5
26uveitis10.5
27myopia10.5
28neuropathy10.4
29pigment-dispersion syndrome10.4
30choroiditis10.4
31retinal vein occlusion10.4
32cataract-glaucoma10.4
33traumatic glaucoma10.4
34diabetic retinopathy10.4
35central retinal vein occlusion10.4
36acute closed-angle glaucoma10.4
37ectropion10.4
38rubeosis iridis10.4
39melanoma10.4
40early-onset glaucoma10.4
41buphthalmos10.3
42endophthalmitis10.3
43keratitis10.3
44scleritis10.3
45retinal detachment10.3
46glaucoma 1, open angle, e10.3
47keratopathy10.2
48glaucoma 3 primary infantile b10.2
49megalocornea - spherophakia - secondary glaucoma10.2
50neurofibromatosis10.2

Graphical network of the top 20 diseases related to Glaucoma:



Diseases related to glaucoma

Symptoms for Glaucoma

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Drugs & Therapeutics for Glaucoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Glaucoma

Drug clinical trials:

Search ClinicalTrials for Glaucoma

Search NIH Clinical Center for Glaucoma

Search CenterWatch for Glaucoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Glaucoma

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Sources:
21GeneTests, 23GTR
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Genetic tests related to Glaucoma:

id Genetic test Affiliating Genes
1 Glaucoma21 23

Anatomical Context for Glaucoma

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Glaucoma:

34
Eye, Endothelial, Testes, Retina, Brain, Heart, Thyroid, Cortex, T cells, Tonsil, Bone marrow, Skin, Lung, Kidney, Bone, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Glaucoma:
id TissueAnatomical CompartmentCell Relevance
1 EyeGanglion Cell LayerMature Ganglion Cells Affected by disease

Animal Models for Glaucoma or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Glaucoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.4TDRD7, ACHE, FOXC1, MYOC, CYP1B1

Publications for Glaucoma

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Sources:
53PubMed
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Articles related to Glaucoma:

(show top 50)    (show all 3453)
idTitleAuthorsYear
1
Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma. (22706338)
2014
2
Long-term Evaluation of Efficacy and Safety of Deep Sclerectomy in Uveitic Glaucoma. (24410348)
2014
3
Anesthesia considerations in pediatric glaucoma management. (24406813)
2014
4
New options for combined cataract and glaucoma surgery. (24389806)
2014
5
Retinal oxygen metabolism in healthy subjects and glaucoma patients. (24403567)
2014
6
Effect of ginkgo biloba on visual field and contrast sensitivity in chinese patients with normal tension glaucoma: a randomized, crossover clinical trial. (24282229)
2014
7
Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. (24215654)
2013
8
Association of open-angle glaucoma with perfusion pressure status in the Thessaloniki Eye Study. (23394905)
2013
9
A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma. (23412091)
2013
10
Selective Laser Trabeculoplasty versus Argon Laser Trabeculoplasty in Patients with Open-Angle Glaucoma: A Systematic Review and Meta-Analysis. (24367649)
2013
11
The efficacy of viscocanalostomy for uncontrollable primary open-angle glaucoma in a developing country. (23412524)
2013
12
Outcome Measures in Glaucoma: A Systematic Review of Cochrane Reviews and Protocols. (24240876)
2013
13
Development in anterior segment imaging for glaucoma. (24370972)
2013
14
Scanning electron microscopy of the trabecular meshwork: understanding the pathogenesis of primary angle closure glaucoma. (22569378)
2012
15
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? (22259235)
2012
16
Confirmation of TBK1 duplication in normal tension glaucoma. (22306015)
2012
17
Clock-hour laminar displacement and age in primary open-angle glaucoma and normal tension glaucoma. (21875431)
2012
18
Comparison between MP-1 and Humphrey visual field defects in glaucoma and retinitis pigmentosa. (22733099)
2012
19
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
20
The relationship between components of metabolic syndrome and open-angle glaucoma. (21481477)
2011
21
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
22
Confirmation and further mapping of the GLC3C locus in primary congenital glaucoma. (21622161)
2011
23
Association of strength of religious adherence with attitudes regarding glaucoma or ocular hypertension. (20714192)
2011
24
Valosin-containing protein is a novel autoantigen in patients with glaucoma. (20935584)
2011
25
Correction of the disease phenotype of myocilin-causing glaucoma by a natural osmolyte. (19234343)
2009
26
Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis. (19684868)
2009
27
A clinical and molecular genetic study of German patients with primary congenital glaucoma. (19195637)
2009
28
Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding data. (19907929)
2009
29
Glaucoma-associated myocilin: a better understanding but much more to learn. (18804106)
2009
30
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (19662433)
2009
31
New developments in glaucoma medical treatment]. (19902393)
2009
32
Variable expressivity and high penetrance of CYP1B1 mutations associated with primary congenital glaucoma. (19744731)
2009
33
Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population. (19471604)
2009
34
Intracameral recombinant tissue plasminogen activator for refractory glaucoma secondary to a fungal corneal abscess. (19888435)
2009
35
Prooxidant-antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. (18607617)
2008
36
Color Doppler imaging of retrobulbar hemodynamics in Sturge-Weber syndrome-associated glaucoma. (18320507)
2008
37
Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension. (19668496)
2007
38
Safety and efficacy of manual small incision cataract surgery for phacolytic glaucoma. (17322465)
2007
39
Non-penetrating deep sclerectomy for glaucoma associated with Sturge-Weber syndrome. (16965497)
2006
40
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension. (16488953)
2006
41
Mutation spectrum of the CYP1B1 gene in Indian primary congenital glaucoma patients. (15475877)
2004
42
Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. (15534471)
2004
43
Cataracts and glaucoma in patients with oculocerebrorenal syndrome. (12963605)
2003
44
Myocilin and glaucoma: facts and ideas. (12150989)
2002
45
Steroid-induced glaucoma after laser in situ keratomileusis associated with interface fluid. (11927421)
2002
46
Detection of gonioscopically occludable angles and primary angle closure glaucoma by estimation of limbal chamber depth in Asians: modified grading scheme. (10655196)
2000
47
Dysgenetic changes of the angle of the anterior chamber in patients with glaucoma or suspected glaucoma acquired before age 40]. (10919117)
2000
48
Alterations of ocular nitric oxide synthase in human glaucoma. (7543463)
1995
49
Genetic spontaneous late subluxation of the lens previously reported as a myopic kinship with primary angle closure glaucoma. (1520099)
1992
50
Factors involved in the production of low tension glaucoma. (4423185)
1974

Variations for Glaucoma

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Expression for genes affiliated with Glaucoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glaucoma

Search GEO for disease gene expression data for Glaucoma.

Pathways for genes affiliated with Glaucoma

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Compounds for genes affiliated with Glaucoma

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Sources:
46Novoseek, 25HMDB, 3BitterDB, 52PharmGKB
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Compounds related to Glaucoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1parathion46 2511.0ACHE, CYP1B1
2coumarin46 3 52 2512.7ACHE, CYP1B1

GO Terms for genes affiliated with Glaucoma

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17Gene Ontology
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Biological processes related to Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:0076019.8WDR36, OCLM, CYP1B1

Products for genes affiliated with Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glaucoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet