MCID: GLC007
MIFTS: 58

Glaucoma malady

Eye diseases category

Summaries for Glaucoma

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Glaucoma is a group of diseases that can damage the eye's optic nerve. it is a leading cause of blindness in the united states. it usually happens when the fluid pressure inside the eyes slowly rises, damaging the optic nerve. often there are no symptoms at first. without treatment, people with glaucoma will slowly lose their peripheral, or side vision. they seem to be looking through a tunnel. over time, straight-ahead vision may decrease until no vision remains. a comprehensive eye exam can tell if you have glaucoma. people at risk should get eye exams at least every two years. they include african americans over age 40 people over age 60, especially mexican americans people with a family history of glaucoma there is no cure, but glaucoma can usually be controlled. early treatment can help protect your eyes against vision loss. treatments usually include prescription eyedrops and/or surgery. nih: national eye institute

MalaCards: Glaucoma is related to open-angle glaucoma and primary open angle glaucoma. An important gene associated with Glaucoma is OPTN (optineurin). The drugs acetazolamide and carbachol and the compound coumarin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes.

Wikipedia:63 Glaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a... more...

Aliases & Classifications for Glaucoma

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Sources:
8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glaucoma family:

Juvenile Glaucoma Primary Congenital Glaucoma
Glaucoma Type 1c Glaucoma, Congenital
Cyp1b1-Related Primary Congenital Glaucoma Ltbp2-Related Primary Congenital Glaucoma
Early-Onset Glaucoma Glaucoma 3, Primary Congenital, D
Glaucoma 3, Primary Congenital, C

Diseases related to Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 464)
idRelated DiseaseScoreTop Affiliating Genes
1open-angle glaucoma31.9CYP1B1, MYOC, WDR36, OPTN
2primary open angle glaucoma31.7OPTN, MYOC, CYP1B1
3primary angle-closure glaucoma31.4MYOC
4ocular hypertension31.4MYOC, OPTN
5primary congenital glaucoma31.2CYP1B1
6aniridia30.7FOXC1
7primary open angle glaucoma juvenile onset 130.4MYOC, CYP1B1
8eye disease30.2FOXC1, OPTN, MYOC
9glaucoma 3, primary congenital, d30.2FOXC1, OPTN, MYOC, CYP1B1
10peters plus syndrome30.1CYP1B1, FOXC1
11axenfeld-rieger syndrome30.0FOXC1, CYP1B1
12optic nerve disease29.8OPTN, MYOC
13neovascular glaucoma11.0
14hypertension11.0
15retinitis10.8
16low tension glaucoma10.8
17juvenile glaucoma10.8
18cataract10.7
19exfoliation syndrome10.6
20phacolytic glaucoma10.5
21steroid-induced glaucoma - borderline10.5
22steroid-induced glaucoma10.5
23uveitis10.5
24myopia10.5
25neuropathy10.4
26choroiditis10.4
27retinal vein occlusion10.4
28traumatic glaucoma10.4
29central retinal vein occlusion10.4
30diabetic retinopathy10.4
31acute closed-angle glaucoma10.4
32ectropion10.3
33rubeosis iridis10.3
34melanoma10.3
35buphthalmos10.3
36endophthalmitis10.3
37keratitis10.3
38optic atrophy10.3
39scleritis10.3
40lens subluxation10.2
41ischemic neuropathy10.2
42retinal artery occlusion10.2
43retinal detachment10.2
44glaucoma 1, open angle, e10.2
45ischemic optic neuropathy10.2
46keratopathy10.2
47glaucoma 3 primary infantile b10.2
48megalocornea - spherophakia - secondary glaucoma10.2
49neurofibromatosis10.2
50chronic closed-angle glaucoma10.2

Graphical network of the top 20 diseases related to Glaucoma:



Diseases related to glaucoma

Clinical Features for Glaucoma

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Drugs & Therapeutics for Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Glaucoma

Drug clinical trials:

Search ClinicalTrials for Glaucoma

Search NIH Clinical Center for Glaucoma

Search CenterWatch for Glaucoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Glaucoma

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Glaucoma:

id Genetic test Affiliating Genes
1 Glaucoma20 22

Anatomical Context for Glaucoma

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Glaucoma:

32
Eye, Endothelial, Testes, Retina, Brain, Thyroid, Heart, Cortex, Bone marrow, Lung, Kidney, T cells, Bone, Pituitary, Skin, Tonsil

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Glaucoma:
id TissueAnatomical CompartmentCell Relevance
1 EyeGanglion Cell LayerMature Ganglion Cells Affected by disease

Animal Models for Glaucoma or affiliated genes

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Publications for Glaucoma

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Sources:
50PubMed
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Articles related to Glaucoma:

(show top 50)    (show all 3487)
idTitleAuthorsYear
1
Anesthesia considerations in pediatric glaucoma management. (24406813)
2014
2
Effect of ginkgo biloba on visual field and contrast sensitivity in chinese patients with normal tension glaucoma: a randomized, crossover clinical trial. (24282229)
2014
3
The effect of phacoemulsification on intraocular pressure in medically controlled open-angle glaucoma patients. (24182743)
2014
4
Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population. (24073598)
2013
5
Clinic-Based Glaucoma Care in the Era of Surgical Subspecialization. (24321471)
2013
6
Arteriovenous passage times and visual field progression in normal tension glaucoma. (24282387)
2013
7
Performance of optical coherence tomography for distinguishing between normal eyes, glaucoma suspect and glaucomatous eyes. (23951826)
2013
8
Is there a link between open-angle glaucoma and dementia?: The Three-City-Alienor Cohort. (23686609)
2013
9
Glaucoma associated with the management of rhegmatogenous retinal detachment. (23620656)
2013
10
Efficacy and safety of pneumatic trabeculoplasty versus timolol added to latanoprost in primary open angle glaucoma. (24045520)
2013
11
Differences in vision between clinic and home and the effect of lighting in older adults with and without glaucoma. (24263699)
2013
12
Neovascular glaucoma induced by peripheral retinal ischemia in neurofibromatosis type 1: management and imaging features. (23687499)
2013
13
The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables. (22828004)
2013
14
Glaucoma treatment compliance. (24332684)
2013
15
Are preservatives necessary to improve efficacy of some glaucoma drops? (24216677)
2013
16
Recurrent endophthalmitis after trabeculectomy for glaucoma: importance of timely filtering bleb coverage for the conjunctiva. (23185177)
2012
17
Alterations in anterior chamber depth in primary open-angle glaucoma patients during latanoprost therapy. (22289195)
2012
18
Long-term medical management of primary open-angle glaucoma and ocular hypertension in the UK: optimizing cost-effectiveness and clinic resources by minimizing therapy switches. (21677590)
2012
19
Open-angle Glaucoma in Filipino and White Americans: A Comparative Study. (23221903)
2012
20
Comparison of combined phacotrabeculectomy with trabeculectomy only in the treatment of primary angle-closure glaucoma. (22613648)
2012
21
Auditory and visual temporal processing disruption in open angle glaucoma. (22879422)
2012
22
Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. (21436445)
2011
23
Central retinal vein occlusion following trabeculectomy with OloGen in patients with advanced glaucoma: a possible side-effect? (20003111)
2010
24
Single nucleotide polymorphisms of metabolic syndrome-related genes in primary open angle glaucoma. (22553514)
2010
25
The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. (21139981)
2010
26
Serum cytokine alteration is associated with optic neuropathy in human primary open angle glaucoma. (19730118)
2010
27
Laser peripheral iridotomy with and without iridoplasty for primary angle-closure glaucoma: 1-year results of a randomized pilot study. (20472226)
2010
28
In vivo morphometry of corneal endothelial cells in pseudoexfoliation keratopathy with glaucoma and cataract. (19365152)
2009
29
Pneumatic trabeculoplasty vs latanoprost as adjunctive therapy to timolol in primary open-angle glaucoma or ocular hypertension. (19247684)
2009
30
Getting the red out: primary angle-closure glaucoma. (19390391)
2009
31
Intravitreal bevacizumab for the treatment of neovascular glaucoma associated with central retinal artery occlusion. (19794952)
2009
32
Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. (18421092)
2008
33
Treatment of iris melanoma and secondary neovascular glaucoma using bevacizumab and plaque radiotherapy. (18413538)
2008
34
The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma. (17188046)
2007
35
Neuroglobin in normal retina and retina from eyes with advanced glaucoma. (17151062)
2007
36
Long-term results of Ahmed glaucoma valve and Molteno implant in neovascular glaucoma. (16215538)
2007
37
Effects of glaucoma medications on corneal endothelium, keratocytes, and subbasal nerves among participants in the ocular hypertension treatment study. (17133051)
2006
38
Low penetrance of His26Asp mutation in the optineurin gene in a Japanese family with normal-tension glaucoma]. (16972651)
2006
39
Bilateral juvenile glaucoma with iridotrabecular dysgenesis, congenital ectropion uveae, and thickened corneal nerves. (15618973)
2005
40
Utility values in Singapore Chinese adults with primary open-angle and primary angle-closure glaucoma. (16276277)
2005
41
Vitrectomy for phacolytic glaucoma in a patient with ectopia lentis et pupillae. (12640414)
2003
42
Primary congenital glaucoma and erupted teeth (natal teeth) in the newborn: a report of two cases. (11563786)
2001
43
Malignant glaucoma (aqueous misdirection) after pars plana vitrectomy. (10889085)
2000
44
Extracapsular cataract extraction with posterior chamber lens implantation in primary angle-closure glaucoma. (9292680)
1997
45
Incidence of acute primary angle-closure glaucoma in Singapore. An island-wide survey. (9366676)
1997
46
Scleritis after glaucoma filtering surgery with mitomycin C. (9097808)
1995
47
Acute closed-angle glaucoma after arteriovenous fistulas. (2913810)
1989
48
Neovascular glaucoma and the occurrence of twin vessels in congenital arteriovenous communications of the retina. (2456906)
1988
49
Congenital glaucoma associated with cutis marmorata telangiectatica congenita: two case reports. (3343635)
1988
50
Factors involved in the production of low tension glaucoma. (4423185)
1974

Genetic Variations for Glaucoma

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Expression for genes affiliated with Glaucoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glaucoma

Search GEO for disease gene expression data for Glaucoma.

Pathways for genes affiliated with Glaucoma

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Compounds for genes affiliated with Glaucoma

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Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Glaucoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1coumarin44 2 49 2413.7ACHE, CYP1B1

GO Terms for genes affiliated with Glaucoma

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Products for genes affiliated with Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet