MCID: GLC007
MIFTS: 58

Glaucoma malady

Eye diseases category

Summaries for Glaucoma

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Glaucoma is a group of diseases that can damage the eye's optic nerve. it is a leading cause of blindness in the united states. it usually happens when the fluid pressure inside the eyes slowly rises, damaging the optic nerve. often there are no symptoms at first. without treatment, people with glaucoma will slowly lose their peripheral, or side vision. they seem to be looking through a tunnel. over time, straight-ahead vision may decrease until no vision remains. a comprehensive eye exam can tell if you have glaucoma. people at risk should get eye exams at least every two years. they include african americans over age 40 people over age 60, especially mexican americans people with a family history of glaucoma there is no cure, but glaucoma can usually be controlled. early treatment can help protect your eyes against vision loss. treatments usually include prescription eyedrops and/or surgery. nih: national eye institute

MalaCards: Glaucoma is related to open-angle glaucoma and primary open angle glaucoma. An important gene associated with Glaucoma is OPTN (optineurin). The drugs acetazolamide and carbachol and the compound coumarin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes.

Wikipedia:63 Glaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a... more...

Aliases & Classifications for Glaucoma

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Sources:
8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glaucoma family:

Juvenile Glaucoma Primary Congenital Glaucoma
Glaucoma Type 1c Glaucoma, Congenital
Cyp1b1-Related Primary Congenital Glaucoma Ltbp2-Related Primary Congenital Glaucoma
Early-Onset Glaucoma Glaucoma 3, Primary Congenital, D
Glaucoma 3, Primary Congenital, C

Diseases related to Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 464)
idRelated DiseaseScoreTop Affiliating Genes
1open-angle glaucoma31.9CYP1B1, MYOC, WDR36, OPTN
2primary open angle glaucoma31.7OPTN, MYOC, CYP1B1
3primary angle-closure glaucoma31.4MYOC
4ocular hypertension31.4MYOC, OPTN
5primary congenital glaucoma31.2CYP1B1
6aniridia30.7FOXC1
7primary open angle glaucoma juvenile onset 130.4MYOC, CYP1B1
8eye disease30.2FOXC1, OPTN, MYOC
9glaucoma 3, primary congenital, d30.2FOXC1, OPTN, MYOC, CYP1B1
10peters plus syndrome30.1CYP1B1, FOXC1
11axenfeld-rieger syndrome30.0FOXC1, CYP1B1
12optic nerve disease29.8OPTN, MYOC
13neovascular glaucoma11.0
14hypertension11.0
15retinitis10.8
16low tension glaucoma10.8
17juvenile glaucoma10.8
18cataract10.7
19exfoliation syndrome10.6
20phacolytic glaucoma10.5
21steroid-induced glaucoma - borderline10.5
22steroid-induced glaucoma10.5
23uveitis10.5
24myopia10.5
25neuropathy10.4
26choroiditis10.4
27retinal vein occlusion10.4
28traumatic glaucoma10.4
29central retinal vein occlusion10.4
30diabetic retinopathy10.4
31acute closed-angle glaucoma10.4
32ectropion10.3
33rubeosis iridis10.3
34melanoma10.3
35buphthalmos10.3
36endophthalmitis10.3
37keratitis10.3
38optic atrophy10.3
39scleritis10.3
40lens subluxation10.2
41ischemic neuropathy10.2
42retinal artery occlusion10.2
43retinal detachment10.2
44glaucoma 1, open angle, e10.2
45ischemic optic neuropathy10.2
46keratopathy10.2
47glaucoma 3 primary infantile b10.2
48megalocornea - spherophakia - secondary glaucoma10.2
49neurofibromatosis10.2
50chronic closed-angle glaucoma10.2

Graphical network of the top 20 diseases related to Glaucoma:



Diseases related to glaucoma

Clinical Features for Glaucoma

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Drugs & Therapeutics for Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Glaucoma

Drug clinical trials:

Search ClinicalTrials for Glaucoma

Search NIH Clinical Center for Glaucoma

Search CenterWatch for Glaucoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Glaucoma

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Glaucoma:

id Genetic test Affiliating Genes
1 Glaucoma20 22

Anatomical Context for Glaucoma

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Glaucoma:

32
Eye, Endothelial, Testes, Retina, Brain, Heart, Thyroid, Cortex, T cells, Tonsil, Bone marrow, Skin, Lung, Kidney, Bone, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Glaucoma:
id TissueAnatomical CompartmentCell Relevance
1 EyeGanglion Cell LayerMature Ganglion Cells Affected by disease

Animal Models for Glaucoma or affiliated genes

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Publications for Glaucoma

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Sources:
50PubMed
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Articles related to Glaucoma:

(show top 50)    (show all 3487)
idTitleAuthorsYear
1
Purtscher's retinopathy followed by neovascular glaucoma. (24255591)
2013
2
Role of rs1533428 and rs12994401 in patients with Primary Open Angle Glaucoma in an European population. (23136999)
2013
3
Automatic screening of narrow anterior chamber angle and angle-closure glaucoma based on slit-lamp image analysis by using support vector machine. (24111078)
2013
4
Selective laser trabeculoplasty (SLT) vs other treatment modalities for glaucoma: systematic review. (24310236)
2013
5
Intracranial pressure fluctuations: a potential risk factor for glaucoma? (24373540)
2013
6
Increased risk of open-angle glaucoma following chronic rhinosinusitis: a population-based matched-cohort study. (24263380)
2013
7
Evaluation of presumptive biomarkers of oxidative stress, immune response and apoptosis in primary open-angle glaucoma. (23142105)
2013
8
Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma. (23852370)
2013
9
Comparison of dorzolamide/timolol and latanoprost/timolol fixed combinations on diurnal intraocular pressure control in primary open-angle glaucoma. (22320418)
2012
10
CDKN2B polymorphism is associated with primary open-angle glaucoma (POAG) in the Afro-Caribbean population of Barbados, West Indies. (22761751)
2012
11
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. (22922875)
2012
12
Tear film osmolarity in patients treated for glaucoma or ocular hypertension. (22710490)
2012
13
Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma. (22831837)
2012
14
Ocular hypertension and normal-tension glaucoma: time for banishment and burial. (21670346)
2011
15
Tumor necrosis factor-alpha (TNF-I+) levels in aqueous humor of primary open angle glaucoma. (21607023)
2011
16
Effect of intravitreal bevacizumab on iris vessels in neovascular glaucoma patients. (20524132)
2010
17
Evaluation of SPARC as a candidate gene of juvenile-onset primary open-angle glaucoma by mutation and copy number analyses. (21042566)
2010
18
Tag SNPs detect association of the CYP1B1 gene with primary open angle glaucoma. (21139974)
2010
19
Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma. (20516145)
2010
20
Intravitreal bevacizumab and aqueous shunting surgery for neovascular glaucoma: safety and efficacy. (19606170)
2009
21
Management of glaucoma in a case of familial aniridia by trabeculectomy. (21141025)
2009
22
Preventing glaucoma in a high-risk population: impact and observations of the Ocular Hypertension Treatment Study. (19204244)
2009
23
Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort. (18287813)
2008
24
A 5-year, randomized, open-label safety study of latanoprost and usual care in patients with open-angle glaucoma or ocular hypertension. (18465724)
2008
25
Efficacy and safety of bimatoprost/timolol fixed combination in the treatment of glaucoma or ocular hypertension. (18076345)
2008
26
Cost-effectiveness of early detection and treatment of ocular hypertension and primary open-angle glaucoma by the ophthalmologist. (17128205)
2008
27
Viscogonioplasty: an effective procedure for lowering intraocular pressure in primary angle closure glaucoma. (16410808)
2007
28
Investigation of the association between normal-tension glaucoma and single nucleotide polymorphisms in natriuretic peptide gene. (17460430)
2007
29
The effects of external subretinal fluid drainage on secondary glaucoma in Coats' disease. (16678751)
2006
30
Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension. (17154662)
2006
31
The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa. (16754204)
2006
32
Secondary glaucoma associated with advanced acanthamoeba keratitis. (16845263)
2006
33
Matrix metalloproteinases and their tissue inhibitors in aqueous humor of patients with primary open-angle glaucoma, exfoliation syndrome, and exfoliation glaucoma. (15650607)
2005
34
Charles Bonnet syndrome in patients with glaucoma and good acuity. (15923534)
2005
35
What is the direct cost of treatment of acute primary angle closure glaucoma? The Singapore model. (15575827)
2004
36
Low prevalence of MYOC mutations in UK primary open-angle glaucoma patients limits the utility of genetic testing. (15338275)
2004
37
Treatment of rubeosis iridis with photodynamic therapy with verteporfin--A new therapeutic and prophylactic option for patients with the risk of neovascular glaucoma? (12566865)
2003
38
In vivo confocal microscopy in primary congenital glaucoma with megalocornea. (11912354)
2002
39
Gonioscopy in primary angle closure glaucoma. (15513458)
2002
40
The efficacy of brimonidine in preventing intraocular pressure elevation in the provocative test for primary angle-closure glaucoma. (12002673)
2002
41
Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter with the severity of primary open-angle glaucoma. (11595024)
2001
42
Ocular decompression retinopathy after resolution of acute primary angle closure glaucoma. (11021564)
2000
43
Novel trabecular meshwork inducible glucocorticoid response mutation in an eight-generation juvenile-onset primary open-angle glaucoma pedigree. (9754180)
1998
44
Aggressive neovascular glaucoma following carotid endarterectomy: a case report. (9315133)
1997
45
Severe vision loss and neovascular glaucoma complicating superior ophthalmic vein approach to carotid-cavernous sinus fistula. (9402840)
1997
46
Finger blood flow in patients with low tension glaucoma and primary open-angle glaucoma. (1739685)
1992
47
Panretinal photocoagulation in the management of neovascular glaucoma. (3187630)
1988
48
Low tension neovascular glaucoma treated by draining implant. (6195799)
1983
49
Treatment of neovascular glaucoma. (95525)
1979
50
Miscellaneous ophthalmic surgery, including two techniques of keratoplasty, cataract, glaucoma, keratectomies and muscles. (20261921)
1947

Genetic Variations for Glaucoma

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Expression for genes affiliated with Glaucoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glaucoma

Search GEO for disease gene expression data for Glaucoma.

Pathways for genes affiliated with Glaucoma

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Compounds for genes affiliated with Glaucoma

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Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Glaucoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1coumarin44 2 49 2413.7ACHE, CYP1B1

GO Terms for genes affiliated with Glaucoma

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Products for genes affiliated with Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet