MCID: GLC007
MIFTS: 49

Glaucoma malady

Eye category

Summaries for Glaucoma

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Glaucoma is a group of diseases that can damage the eye's optic nerve. it is a leading cause of blindness in the united states. it usually happens when the fluid pressure inside the eyes slowly rises, damaging the optic nerve. often there are no symptoms at first. without treatment, people with glaucoma will slowly lose their peripheral, or side vision. they seem to be looking through a tunnel. over time, straight-ahead vision may decrease until no vision remains. a comprehensive eye exam can tell if you have glaucoma. people at risk should get eye exams at least every two years. they include african americans over age 40 people over age 60, especially mexican americans people with a family history of glaucoma there is no cure, but glaucoma can usually be controlled. early treatment can help protect your eyes against vision loss. treatments usually include prescription eyedrops and/or surgery. nih: national eye institute

MalaCards: Glaucoma is related to primary open angle glaucoma and ocular hypertension. An important gene associated with Glaucoma is OPTN (optineurin). The drugs acetazolamide and carbachol and the compound coumarin have been mentioned in the context of this disorder.

Wikipedia:64 Glaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a... more...

Aliases & Classifications for Glaucoma

Sources:
8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

glaucoma 8 20 22 10 45 34 61


External Ids:

Disease Ontology8 DOID:1686
NCIt40 C26782
ICD9CM27 365.9, 365
MeSH35 D005901

Related Diseases for Glaucoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Glaucoma family:

juvenile glaucoma primary congenital glaucoma
glaucoma type 1c glaucoma, congenital
early-onset glaucoma glaucoma 3, primary congenital, d
glaucoma 3, primary congenital, c

Diseases related to Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 456)
idRelated DiseaseScoreTop Affiliating Genes
1primary open angle glaucoma31.8OPTN, MYOC, CYP1B1
2ocular hypertension31.4MYOC, OPTN
3primary congenital glaucoma31.3CYP1B1
4aniridia30.8FOXC1
5primary open angle glaucoma juvenile onset 130.4MYOC, CYP1B1
6blindness30.4FOXC1, OPTN, WDR36, MYOC
7glaucoma 3, primary congenital, d30.1FOXC1, OPTN, MYOC, CYP1B1
8peters plus syndrome30.0CYP1B1, FOXC1
9axenfeld-rieger syndrome30.0FOXC1, CYP1B1
10neovascular glaucoma11.0
11glaucoma, congenital11.0
12juvenile glaucoma10.8
13cataract-glaucoma10.8
14exfoliation syndrome10.6
15sturge-weber syndrome10.6
16phacolytic glaucoma10.6
17weber syndrome10.6
18steroid-induced glaucoma10.5
19n syndrome10.5
20uveitis10.5
21pigment-dispersion syndrome10.4
22early-onset glaucoma10.4
23traumatic glaucoma10.4
24central retinal vein occlusion10.4
25acute closed-angle glaucoma10.4
26glaucoma 1, open angle, g10.4
27rubeosis iridis10.3
28glaucoma 1, open angle, e10.3
29glaucoma 1, open angle, p10.3
30buphthalmos10.3
31low tension glaucoma10.3
32ischemic neuropathy10.3
33megalocornea - spherophakia - secondary glaucoma10.3
34ischemic optic neuropathy10.2
35glaucoma 3 primary infantile b10.2
36neurofibromatosis10.2
37lens subluxation10.2
38chronic closed-angle glaucoma10.2
39anterior uveitis10.2
40glaucoma, hereditary10.2
41congenital ectropion uveae10.2
42central retinal artery occlusion10.2
43proliferative diabetic retinopathy10.2
44rubinstein-taybi syndrome10.2
45microcornea, glaucoma, and absent frontal sinuses10.2
46retinal degeneration with nanophthalmos, cystic macular degeneration, and angle closure glaucoma10.2
47glaucoma 1, open angle, m10.2
48corneal disease10.2
49interval angle-closure glaucoma10.2
50weill-marchesani syndrome10.2

Graphical network of the top 20 diseases related to Glaucoma:



Diseases related to glaucoma

Clinical Features for Glaucoma

Drugs & Therapeutics for Glaucoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Glaucoma

Drug clinical trials:

Search ClinicalTrials for Glaucoma

Search NIH Clinical Center for Glaucoma

Search CenterWatch for Glaucoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Glaucoma

Sources:
20GeneTests, 22GTR
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Genetic tests related to Glaucoma:

id Genetic test Affiliating Genes
1 Glaucoma20 22

Anatomical Context for Glaucoma

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Glaucoma:
id TissueAnatomical CompartmentCell Relevance
1 EyeGanglion Cell LayerMature Ganglion Cells Affected by disease

Animal Models for Glaucoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Glaucoma

Sources:
51PubMed
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Articles related to Glaucoma:

(show top 50)    (show all 3588)
idTitleAuthorsYear
1
Randomized, Prospective, Comparative Trial of EX-PRESS Glaucoma Filtration Device versus Trabeculectomy (XVTA Study). (24210765)
2014
2
Corneal viscoelastic differences between pseudoexfoliative glaucoma and primary open-angle glaucoma. (24299728)
2013
3
Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma. (23867241)
2013
4
Electrophysiological tests in evaluation of glaucoma and ocular hypertension treatment--up to date knowledge. A review. (24059033)
2013
5
Infantile bilateral glaucoma in a child with ectodermal dysplasia. (22428923)
2013
6
A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response. (23876925)
2013
7
Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors. (23433313)
2013
8
Managing a patient with open-angle glaucoma: a case study. (23520424)
2012
9
Randomized crossover study of latanoprost and travoprost in eyes with open-angle glaucoma. (21858678)
2012
10
Infantile glaucoma in Rubinstein-Taybi syndrome. (22722488)
2012
11
A clinical and molecular genetics study of primary congenital glaucoma in South Korea. (22942166)
2012
12
Delayed sterile endophthalmitis after glaucoma drainage implantation. (21958177)
2011
13
Mortality in primary open-angle glaucoma: 'two cupped discs and a funeral'. (19247389)
2010
14
Intravitreal bevacizumab injection and carotid artery stent replacement for neovascular glaucoma in internal carotid artery occlusion. (21060668)
2010
15
Randomised controlled trial of screening and prophylactic treatment to prevent primary angle closure glaucoma. (20530662)
2010
16
Comparative study of three prostaglandin analogues in the treatment of newly diagnosed cases of ocular hypertension, open-angle and normal tension glaucoma. (20456437)
2010
17
Port-wine vascular malformations and glaucoma risk in Sturge-Weber syndrome. (20227634)
2010
18
Primary open-angle glaucoma. (19537321)
2009
19
Bevacizumab (Avastin) for the management of anterior chamber neovascularization and neovascular glaucoma. (20054417)
2009
20
Network analysis of human glaucomatous optic nerve head astrocytes. (19426536)
2009
21
Potential diagnostic value of fluorescein angiography and color Doppler imaging in primary open angle glaucoma. (19882582)
2009
22
Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of juvenile glaucoma with goniodysgenesis. (19668597)
2009
23
From epidemiology to lysyl oxidase like one (LOXL1) polymorphisms discovery: phenotyping and genotyping exfoliation syndrome and exfoliation glaucoma in Iceland. (19664108)
2009
24
Plateau iris in Asian subjects with primary angle closure glaucoma. (19822841)
2009
25
Utility assessment among patients of primary angle closure/glaucoma in China: a preliminary study. (19208679)
2009
26
Plasminogen activator inhibitor-1 4G/5G gene polymorphism and primary open-angle glaucoma. (18615155)
2008
27
Management of angle-closure glaucoma in East Asian eyes: a response to argon laser iridotomy-induced bullous keratopathy, a growing problem in Japan. (18723753)
2008
28
Serotonin levels in aqueous humor of patients with primary open-angle glaucoma. (19052654)
2008
29
Potential role for angiotensin-converting enzyme inhibitors in the treatment of glaucoma. (19668475)
2007
30
Travoprost in the management of open-angle glaucoma and ocular hypertension. (19668462)
2007
31
Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension. (17095090)
2007
32
Intraocular pressure-lowering efficacy of bimatoprost 0.03% and travoprost 0.004% in patients with glaucoma or ocular hypertension. (16825272)
2006
33
Trabeculectomy with mitomycin C combined with direct cauterization of peripheral iris in the management of neovascular glaucoma. (16988612)
2006
34
Cochlin and glaucoma: a mini-review. (16332271)
2005
35
Role of oxidative stress enzymes in open-angle glaucoma. (15332106)
2005
36
Mesomelic form of chondrodysplasia and congenital glaucoma associated with de novo translocation (13;18)(q14;q23). (15287419)
2004
37
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro. (15500824)
2004
38
Novel mutations in the MYOC/GLC1A gene in a large group of glaucoma patients. (12442283)
2002
39
Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma. (12073024)
2002
40
Rapid mutation detection by the transgenomic wave analyser DHPLC identifies MYOC mutations in patients with ocular hypertension and/or open angle glaucoma. (11815346)
2002
41
Cystoid macular edema associated with topical latanoprost in glaucomatous eyes with a normally functioning blood-ocular barrier. (11442189)
2001
42
Linkage of autosomal recessive primary congenital glaucoma to the GLC3A locus in Roms (Gypsies) from Slovakia. (9463798)
1998
43
Cataract extraction and intraocular lens implantation in eyes with phacomorphic or phacolytic glaucoma. (8784641)
1996
44
Use of scheimpflug photography to study iris configuration in patients with pigment dispersion syndrome and pigmentary glaucoma. (19920706)
1995
45
Distribution and morphology of peripheral anterior synechiae in primary angle-closure glaucoma. (19920514)
1993
46
The vascular factor in low tension glaucoma: alchemists' gold? (1739682)
1992
47
Neovascular glaucoma after intracapsular and extracapsular cataract extraction in diabetic patients. (2420182)
1986
48
Aniridia, congenital glaucoma, and hydrocephalus in a male infant with ring chromosome 6. (3777023)
1986
49
Iridectomy in primary angle-closure glaucoma. Classification and differential diagnosis of glaucoma associated with narrowness of the angle. (4810644)
1974
50
Primary angle-closure glaucoma. Prevention and early treatment. (4265110)
1972

Genetic Variations for Glaucoma

Expression for genes affiliated with Glaucoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Glaucoma

Search GEO for disease gene expression data for Glaucoma.

Pathways for genes affiliated with Glaucoma

Compounds for genes affiliated with Glaucoma

Sources:
45Novoseek, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Glaucoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1coumarin45 2 50 2413.7ACHE, CYP1B1

GO Terms for genes affiliated with Glaucoma

Products for genes affiliated with Glaucoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glaucoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet