Glaucoma malady

MedlinePlus: Glaucoma damages the eye's optic nerve. it is a leading cause of blindness in the united states. it usually happens when the fluid pressure inside the eyes slowly rises, damaging the optic nerve. often there are no symptoms at first, but a comprehensive eye exam can detect it. people at risk should get eye exams at least every two years. they include african americans over age 40 people over age 60, especially mexican americans people with a family history of glaucoma early treatment can help protect your eyes against vision loss. treatments usually include prescription eyedrops and/or surgery. nih: national eye institute²³

MalaCards: Glaucoma is related to primary open angle glaucoma and open-angle glaucoma. An important gene associated with Glaucoma is OPTN (optineurin), and among its related pathways are Pathways in cancer and eNOS Signaling. The drugs mitomycin and clonidine and the compounds lipid and estrogen have been mentioned in the context of this disorder. Affiliated tissues include retina, t cells and b cells, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Wikipedia: Glaucoma is an eye disease in which the optic nerve is damaged in a characteristic pattern. This can...⁴⁴ more...

Aliases & Descriptions:

glaucoma 6 7 16 17 8 32 23 43

Disease types for glaucoma family:

glaucoma type 1c	glaucoma 1f

Diseases related to glaucoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1102)

id	Related Disease	Score	Top Affiliating Genes
1	primary open angle glaucoma	54.2	COCH, SERPINE1, LMX1B, VAMP5, VAMP8, MYOC
2	open-angle glaucoma	41.9	LMX1B, MYOC, BMP4, BMP7, BMPR2, MMP1
3	primary congenital glaucoma	37.3	MYOC, FOXC1, GLC3B, GLC3C, CYP1B1, LTBP2
4	retinitis	37.1	COCH, CNR1, CNTF, VWF, VSX1, VSX2
5	primary angle-closure glaucoma	36.1	VSX2, VAV2, VAV3, MYOC, LDLR, MMP9
6	interval angle-closure glaucoma	35.7	VSX2, VAV2, VAV3, MYOC, RAMP2, CLU
7	cataract	35.6	VSX2, GCNT2, SERPINF1, VEGFA, MYOC, BMP6
8	exfoliation syndrome	34.9	CLU, MMP1, FBN1, LOXL1, EDNRA, EDNRB
9	blindness	34.8	ZNF469, REN, CNR1, CNTF, VWF, SELE
10	neuronitis	34.6	NCK2, REN, RET, CNR1, CNTF, VWF
11	pancreatitis	34.4	REN, RET, CNR1, VWF, RDX, SFRP1
12	low tension glaucoma	34.3	NCK2, RASSF3, XPOT, SRBD1, SNX16, RHO
13	neuropathy	34.1	REN, CNR1, CNTF, VWF, SELE, SERPINF1
14	homocysteine	33.6	REN, VWF, SELE, SERPINE1, SERPINA3, VEGFA
15	alzheimer's disease	33.2	REN, RET, CNR1, CNTF, SERPINF1, SERPINE1
16	early-onset glaucoma	33.2	MYOC, MTMR2, MTM1, SBF1, SBF2, CYP1B1
17	cholesterol	33.0	REN, CNR1, CNTNAP4, VWF, SELE, SERPINE1
18	atherosclerosis	32.7	REN, CNR1, VWF, SELE, SERPINF1, SERPINE1
19	ocular hypertension	32.6	MYOC, HTR1A, HSD11B2, HSD11B1, NR3C1, PDIA5
20	hypertension	32.6	REN, CYP11B2, NOS2, NOS3, ACE, AGT
21	cataract-glaucoma	32.5	PAX6, FOXC1, GSR, AKR1B1, GJA1, OTX2
22	glaucoma, congenital	32.1	MYOC, PAX6, FOXC1, CYP1B1, TYR, OPTN
23	diabetic retinopathy	31.7	CNR1, VWF, SELE, SERPINF1, SERPINE1, VEGFA
24	aniridia	30.9	PAX6, BDNF, FOXC1, FOXE3, CAT, HRAS
25	axenfeld-rieger syndrome	30.7	FOXC1, FOXP2, GJA1, CYP1B1, PITX2, SH3PXD2B
26	buphthalmos	30.5	MYOC, MFAP2, GLC3B, CYP1B1, LTBP2
27	vascular disease	30.4	VWF, SELE, SERPINE1, VEGFA, BMP6, BMPR2
28	short stature	30.2	REN, LMX1B, BMP5, MRXSA, MMP9, FBN1
29	seizures	30.2	CNR1, CNTF, VEGFA, PAFAH1B1, PARP1, PAX6
30	cleft palate	29.8	BMP4, BMP6, BCOR, MTRR, MTHFR, MTR
31	retinal degeneration	29.5	CNTF, SERPINF1, BMP6, RAB8A, CLU, BEST1
32	age related macular degeneration	29.5	SELE, SERPINF1, SERPINE1, SERPINA3, VEGFA, BMP4
33	primary open anle glaucoma	29.4	CNTNAP4, PCOLCE2, VAMP5, UFSP2, ASB10, CAV2
34	peters anomaly	29.3	MYOC, PAX6, FOXC1, FOXE3, FOXP2, CYP1B1
35	thrombosis	29.1	REN, VWF, GCNT2, SELE, SERPINF1, SERPINE1
36	microphthalmia	29.1	VSX2, GCNT2, BMP4, BEST1, PAX6, BCOR
37	tooth disease	29.0	CNTF, MTMR2, MTM1, SBF1, SBF2, GSTP1
38	charcot-marie-tooth disease	29.0	CNTF, MTMR2, MTM1, SBF1, SBF2, GSTP1
39	mental retardation syndrome	28.9	RDX, PAX6, BDNF, BCOR, MTR, FOXC1
40	macular degeneration	28.9	CNTF, VWF, VSX1, SELE, SERPINF1, SERPINE1
41	anemia	28.5	REN, VWF, SELE, VEGFA, BMP6, BMP7
42	leber hereditary optic neuropathy	28.4	MYOC, MT-ND4, MT-CO3, MT-ND1, MT-ND6, OPA1
43	retinal vein occlusion	28.4	VWF, SERPINF1, SERPINE1, VEGFA, MTHFR, IL10
44	sickle cell anemia	28.3	VWF, SELE, BMP6, CLU, LDLR, MTHFR
45	weill-marchesani syndrome	28.0	FBN1, TNF, LTBP1, LTBP2, LTBP3, ADAMTS10
46	central retinal vein occlusion	27.8	VWF, SERPINE1, VEGFA, MTHFR, IL6, PLAT
47	hydrocephalus	27.5	VSX1, BDNF, UBC, MTHFR, FOXC1, FOXL1
48	carcinoma	19.3	REN, RET, CNR1, CNTF, VWF, RDX
49	prostatitis	19.0	RET, CNR1, CNTF, VWF, RDX, SFRP1
50	esophagitis	18.2	RET, CNR1, SFRP1, SELE, SERPINE1, SERPINA3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetazolamide, acetazolamide sodium, carbachol, clonidine, clonidine hcl pwdr [va product], clonidine hydrochloride, dichlorphenamide, isoflurophate, mitomycin, physostigmine, physostigmine salicylate, physostigmine sulfate

Genetic tests related to glaucoma:

id	Genetic test	Affiliating Genes
1	Glaucoma clinical/research

MalaCards organs/tissues related to glaucoma:

²²

MGI Mouse Phenotypes related to glaucoma:

²⁵ (show all 30)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	15.4	NCK2, REN, RET, CNR1, CNTF, VWF
2	nervous system phenotype	MP:0003631	15.0	NCK2, REN, CNR1, CNTF, VWF, VSX1
3	cardiovascular system phenotype	MP:0005385	14.3	REN, RET, VWF, SFRP1, SELE, SERPINF1
4	mortality/aging	MP:0010768	14.1	NCK2, REN, RET, CNR1, VWF, VSX2
5	reproductive system phenotype	MP:0005389	13.5	REN, RET, VSX2, SERPINF1, VEGFA, BMP7
6	vision/eye phenotype	MP:0005391	13.5	VSX1, VSX2, SELE, SERPINF1, VEGFA, LMX1B
7	renal/urinary system phenotype	MP:0005367	13.3	NCK2, REN, RET, GCNT2, LMX1B, VAMP8
8	muscle phenotype	MP:0005369	13.1	REN, RET, CNTF, VEGFA, VCP, LMX1B
9	cellular phenotype	MP:0005384	13.1	NCK2, RET, CNR1, CNTF, VWF, SELE
10	behavior/neurological phenotype	MP:0005386	13.1	NCK2, REN, CNR1, CNTF, VSX1, RDX
11	no phenotypic analysis	MP:0003012	13.0	RET, CNR1, VSX2, SFRP1, VEGFA, LMX1B
12	skeleton phenotype	MP:0005390	12.7	CNR1, SFRP1, VEGFA, VCP, LMX1B, BMP4
13	pigmentation phenotype	MP:0001186	12.5	VSX2, SERPINF1, BMP7, BEST1, PAX6, BCL2
14	growth/size phenotype	MP:0005378	12.4	NCK2, REN, RET, CNR1, SFRP1, SELE
15	adipose tissue phenotype	MP:0005375	12.0	CNR1, SFRP1, SERPINE1, BCL2, ZEB1, LDLR
16	normal phenotype	MP:0002873	11.9	COCH, NCK2, REN, RET, PCOLCE2, SELE
17	endocrine/exocrine gland phenotype	MP:0005379	11.9	RET, VSX2, VAMP8, VAV2, BMP5, PAFAH1B1
18	integument phenotype	MP:0010771	11.8	CNR1, GCNT2, LMX1B, RAMP2, PARP1, PAX6
19	hearing/vestibular/ear phenotype	MP:0005377	11.7	COCH, RDX, BMP4, BMP5, BMP7, PARP1
20	liver/biliary system phenotype	MP:0005370	11.7	RDX, VEGFA, BMP4, BMP5, RAMP2, MTM1
21	embryogenesis phenotype	MP:0005380	11.5	NCK2, RET, SFRP1, BMP5, BMPR2, RAMP2
22	tumorigenesis	MP:0002006	11.4	RET, SERPINE1, PAX6, BCL2, BCL2L1, ZEB1
23	digestive/alimentary phenotype	MP:0005381	11.4	RET, VWF, SERPINF1, VEGFA, VAMP8, VAV2
24	respiratory system phenotype	MP:0005388	11.4	RET, BMP5, BMPR2, PAX6, PARL, BDNF
25	limbs/digits/tail phenotype	MP:0005371	11.3	RET, SFRP1, VEGFA, LMX1B, BMP4, BMP5
26	hematopoietic system phenotype	MP:0005397	11.1	CNTF, SFRP1, GCNT2, VAMP8, VAV2, VAV3
27	craniofacial phenotype	MP:0005382	11.0	LMX1B, BMP4, BMP5, PAX6, BDNF, BCOR
28	immune system phenotype	MP:0005387	10.6	REN, CNTF, VWF, SFRP1, PCOLCE2, GCNT2
29	other phenotype	MP:0005395	10.2	CNR1, CLU, LDLR, FOXC1, FN1, IL13
30	taste/olfaction phenotype	MP:0005394	10.0	CNR1, LMX1B, PAX6, BDNF, ZEB1, ENO2

Articles related to glaucoma:

(show top 50)    (show all 705)

id	Title	Authors	Year	Affiliating Genes
1	Distribution of COL8A2 and COL8A1 gene variants in Ca ucasian primary open angle glaucoma patients with thin central corneal thicknes s. (21139683)	Desronvil T.... Wiggs J.L.	2010	COL8A1, COL8A2
2	Evaluation of SPARC as a candidate gene of juvenile-o nset primary open-angle glaucoma by mutation and copy number analyses. (21042566)	Chen L.J.... Pang C.P.	2010	SPARC
3	Regulation of endocytic trafficking of transferrin re ceptor by optineurin and its impairment by a glaucoma-associated mutant. (20085643)	Nagabhushana A.... Swarup G.	2010	TFRC, UBC, RAB8A
4	Little evidence for association of the glaucoma gene MYOC with open-angle glaucoma. (20447966)	Sohn S.... Kee C.	2010	MYOC
5	Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Pe tersburg (20198978)	Motushchuk A.E.... Vasil'ev V.B.	2009	CYP1B1, MYOC, WDR36
6	Level of vascular endothelial growth factor in aqueou s humor and surgical results of ahmed glaucoma valve implantation in patients w ith neovascular glaucoma. (19680051)	Kim Y.G.... Kim C.Y.	2009	VEGFA, TGFB2
7	Lysyl Oxidase-like 1 Gene Polymorphisms in German Patients With Normal Tension Glaucoma, Pigmentary Glaucoma and Exfoliation Glaucoma. (19373106)	Wolf C.... Weisschuh N.	2009	LOXL1
8	LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. (18958304)	Tanito M.... Iwata T.	2008	LOXL1
9	Exfoliation syndrome and exfoliation glaucoma-associated LOXL1 variations are not involved in pigment dispersion syndrome and pigmentary glaucoma. (18618003)	Rao K.N.... Chakrabarti S.	2008	LOXL1
10	Myocilin mutations among primary open angle glaucoma patients of Kanyakumari district, South India. (17417611)	Rose R.... Jayaraman G.	2007	MYOC
11	What increases outflow resistance in primary open-angle glaucoma? (17998032)	Tamm E.R.... Fuchshofer R.	2007	BMP7, TGFB2
12	Normal tension glaucoma is not associated with the interleukin -1alpha (-889) genetic polymorphism. (17473736)	Wang C.Y.... Fan S.S.	2007	IL1A
13	A study on the association of apolipoprotein E genotypes with primary open-angle glaucoma and primary angle-closure glaucoma in northeast of China (17706090)	Yuan H.P.... Yang B.B.	2007	LDLR, APOE
14	Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma. (17417602)	RAPnkkAP S.... Uusitalo H.	2007	PLA2G2A, PLA2G6
15	Glaucoma with aniridia and isolated congenital glaucoma in siblings: contribution and limits of genetics (17287671)	Lise-Schneider B.... Costet-Fighiera C.	2007	PAX6, PITX2, FOXC1
16	IgG antibody patterns in aqueous humor of patients with primary open angle glaucoma and pseudoexfoliation glaucoma. (17893658)	Joachim S.C.... Grus F.H.	2007	GAPDH, ENO1
17	Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery? (16809382)	Souchier M.... Creuzot-Garcher C.	2006	MUC5AC
18	OPTN gene: profile of patients with glaucoma from India. (16885925)	Sripriya S.... Kumaramanickavel G.	2006	OPTN
19	Of mice and men: tyrosinase modification of congenital glaucoma in mice but not in humans. (16565383)	Bidinost C.... Bejjani B.A.	2006	CYP1B1, TYR
20	Genotype and phenotype correlations in congenital glaucoma. (17471339)	Hollander D.A.... Alvarado J.A.	2006	CYP1B1
21	A myocilin Gln368STOP homozygote does not exhibit a more severe glaucoma phenotype than heterozygous cases. (16458712)	Hewitt A.W.... Mackey D.A.	2006	MYOC
22	Analysis of MYOC gene mutation in a Chinese glaucoma family with primary open-angle glaucoma and primary congenital glaucoma. (16863615)	Zhuo Y.H.... Ge J.	2006	MYOC
23	The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa. (16754204)	Fingert J.H.... Stone E.M.	2006	MTHFR
24	Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population. (15914614)	Hashizume K.... Miyaki K.	2005	ACE, AGTR2, AGTR1
25	Analysis of rare variants and common haplotypes in th e optineurin gene in Swedish glaucoma cases. (16020311)	Jansson M.... Sarfarazi M.	2005	OPTN
26	Matrix metalloproteinases and their tissue inhibitors in aqueous humor of patients with primary open-angle glaucoma, exfoliation syndrome, and exfoliation glaucoma. (15650607)	MAoAottAo M.... Sorsa T.	2005	TIMP2
27	Mutations in the optineurin gene in Japanese patients with primary open-angle glaucoma and normal tension glaucoma. (14755458)	Toda Y.... Yamagata Z.	2004	OPTN
28	Pharmacologic neuroprotection with an inhibitor of ni tric oxide synthase for the treatment of glaucoma. (15036557)	Neufeld A.H.	2004	NOS2
29	A genomewide scan identifies novel early-onset primary open-angle glaucoma loci on 9q22 and 20p12. (15108121)	Wiggs J.L.... Haines J.L.	2004	GLC1K, GLC1J
30	Low frequency of myocilin mutations in Indian primary open-angle glaucoma patients. (15025728)	Sripriya S.... Kumaramanickavel G.	2004	MYOC
31	Adult-onset primary glaucoma and molecular genetics: a review. (15206647)	Frezzotti R.... Frezzotti P.	2004	OPTN
32	A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. (15471865)	Dinour D.... Romero M.F.	2004	SLC4A4
33	Allelic variants in the MYOC/TIGR gene in patients with primary open-angle, exfoliative glaucoma and unaffected controls. (12789574)	Jansson M.... Wadelius C.	2003	MYOC
34	Mutations in the myocilin gene in families with primary open-angle glaucoma and juvenile open-angle glaucoma. (12860809)	Bruttini M.... Renieri A.	2003	MYOC
35	The association between Japanese primary open-angle glaucoma and normal tension glaucoma patients and the optineurin gene. (12811537)	Tang S.... Yamagata Z.	2003	OPTN
36	Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma. (12073024)	Aung T.... Bhattacharya S.S.	2002	OPA1
37	Rapid mutation detection by the transgenomic wave analyser DHPLC identifies MYOC mutations in patients with ocular hypertension and/or open angle glaucoma. (11815346)	Cobb C.J.... McLean W.H.	2002	MYOC
38	Primary congenital glaucoma: three case reports on novel mutations and combinations of mutations in the GLC3A (CYP1B1) gene. (11558822)	Michels-Rautenstrauss K.G.... Rautenstrauss B.W.	2001	CYP1B1
39	Analysis of myocilin gene mutations in Japanese patients with normal tension glaucoma and primary open-angle glaucoma. (11298682)	Mabuchi F.... Tsukahara S.	2001	MYOC
40	The role of myocilin/TIGR in glaucoma: results of the Glaucoma Research Foundation catalyst meeting in Berkeley, California, March 2000. (11558819)	Tamm E.R.... Russell P.	2001	MYOC
41	Dysgenetic changes of the angle of the anterior chamber in patients with glaucoma or suspected glaucoma acquired before age 40 (10919117)	Kniestedt C.... Gloor B.P.	2000	MYOC
42	Novel mutation in the MYOC gene in primary open glaucoma patients. (10819638)	Vasconcellos J.P.C.... Costa F.F.	2000	MYOC
43	Molecular characterisation of congenital glaucoma in a consanguineous Canadian community: a step towards preventing glaucoma related blindness. (10851252)	Martin S.N.... HAcon E.	2000	CYP1B1
44	Increased ocular pressure in two patients with narrow angle glaucoma treated with venlafaxine. (9579301)	Aragona M.... Inghilleri M.	1998	SLC18A2
45	TIGR gene in primary open-angle glaucoma and steroid-induced glaucoma. (9510647)	Kee C.... Ahn B.H.	1997	MYOC
46	Familial glaucoma iridogoniodysplasia maps to a 6p25 region implicated in primary congenital glaucoma and iridogoniodysgenesis anomaly. (9382099)	Jordan T.... Bhattacharya S.	1997	FOXC1
47	Probable exclusion of GLC1A as a candidate glaucoma gene in a family with middle-age-onset primary open-angle glaucoma. (8684791)	Richards J.E.... Boehnke M.	1996	MYOC
48	Association of endothelin-1 with normal tension glaucoma: clinical and fundamental studies. (7660312)	Sugiyama T.... Azuma I.	1995	EDN1
49	Spectrometric investigations in ocular hypertension a nd early stages of primary open angle glaucoma and of low tension glaucoma--mul tisubstance analysis. (1428553)	Schweitzer D.... Hammer M.	1992	RHO
50	Primary open angle glaucoma and low tension glaucoma--pathogenesis and mechanism of optic nerve damage (1485570)	Iwata K.	1992	ELN

Genes related to glaucoma according to GeneCards:

(show top 50)    (show all 385)

id	Symbol	Description	Score	GeneCards Section Context
1	OPTN	optineurin	11.1	Publications, Summaries, Aliases & Descriptions
2	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	11.1	Summaries, Aliases & Descriptions, Publications
3	WDR36	WD repeat domain 36	11.1	Publications, Summaries, Orthologs, Aliases & Descriptions
4	MYOC	myocilin, trabecular meshwork inducible glucocorticoid response	11.1	Publications, Expressions, Summaries
5	FOXC1	forkhead box C1	11.1	Summaries, Publications
6	GLC1J	glaucoma 1, open angle, J (juvenile-onset)	11.0	Aliases & Descriptions, Publications
7	OCLM	oculomedin	11.0	Publications, Summaries
8	GLC1M	glaucoma 1, open angle, M (juvenile-onset)	11.0	Aliases & Descriptions, Publications
9	TMCO1	transmembrane and coiled-coil domains 1	11.0	Publications, Summaries
10	TDRD7	tudor domain containing 7	11.0	Summaries, Publications
11	CDKN2B-AS1	CDKN2B antisense RNA 1	11.0	Summaries, Publications
12	ACHE	acetylcholinesterase	11.0	Publications, Summaries
13	GLC3C	glaucoma 3, primary congenital, C	11.0	Aliases & Descriptions, Publications
14	GLC3B	glaucoma 3, primary infantile, B	11.0	Aliases & Descriptions, Publications
15	GLC1K	glaucoma 1, open angle, K (juvenile-onset)	11.0	Publications, Aliases & Descriptions
16	GLC1B	glaucoma 1, open angle, B (adult-onset)	11.0	Publications, Aliases & Descriptions
17	GLC1C	glaucoma 1, open angle, C	11.0	Publications, Aliases & Descriptions
18	PADI2	peptidyl arginine deiminase, type II	11.0	Publications, Summaries
19	BMP5	bone morphogenetic protein 5	11.0	Summaries
20	GLC1N	glaucoma 1, open angle, N (juvenile-onset)	11.0	Publications, Aliases & Descriptions
21	GLC1L	glaucoma 1, open angle, L (adult-onset)	11.0	Aliases & Descriptions, Publications
22	GLC1H	glaucoma 1, open angle, H (adult-onset)	11.0	Publications, Aliases & Descriptions
23	GLC1I	glaucoma 1, open angle, I	11.0	Aliases & Descriptions
24	IHG1	iris hypoplasia with glaucoma 1	11.0	Aliases & Descriptions
25	GLC1D	glaucoma 1, open angle, D (adult-onset)	11.0	Aliases & Descriptions
26	GLC1F	glaucoma 1, open angle, F (adult-onset)	11.0	Publications, Aliases & Descriptions
27	GLC2A	glaucoma 2, angle closure	11.0	Aliases & Descriptions
28	GLC1P	glaucoma 1, open angle, P	11.0	Aliases & Descriptions, Publications
29	GPDS1	glaucoma-related pigment dispersion syndrome 1	11.0	Aliases & Descriptions, Publications
30	TGFB2	transforming growth factor, beta 2	11.0	Publications
31	OPA1	optic atrophy 1 (autosomal dominant)	11.0	Publications
32	ELN	elastin	11.0	Publications
33	LOXL1	lysyl oxidase-like 1	11.0	Publications
34	NTF4	neurotrophin 4	11.0	Publications
35	PAX6	paired box 6	11.0	Publications
36	EDN1	endothelin 1	11.0	Publications
37	COCH	coagulation factor C homolog, cochlin (Limulus polyphemus)	11.0	Publications
38	LTBP2	latent transforming growth factor beta binding protein 2	11.0	Publications
39	LMX1B	LIM homeobox transcription factor 1, beta	11.0	Publications
40	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
41	RHO	rhodopsin	11.0	Publications
42	APOE	apolipoprotein E	11.0	Publications
43	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
44	GSTM1	glutathione S-transferase mu 1	11.0	Publications
45	LDLR	low density lipoprotein receptor	11.0	Publications
46	VAMP5	vesicle-associated membrane protein 5 (myobrevin)	11.0	Publications
47	OPTC	opticin	11.0	Publications
48	CTSA	cathepsin A	11.0	Publications
49	CAV2	caveolin 2	11.0	Publications
50	ELOVL5	ELOVL fatty acid elongase 5	11.0	Publications

Pathways related to glaucoma according to GeneDecks:

(show top 50)    (show all 124)

id	Pathway	Score	Top Affiliating Genes
1	Pathways in cancer20	11.6	RET, VEGFA, BMP4, BCL2, BCL2L1, BAX
2	eNOS Signaling36	11.6	BMP5, BMP6, BMP7, BDNF, IL2, AQP1
3	Molecular Mechanisms of Cancer36	11.3	BMP4, BMP5, BMP6, BMP7, BMPR2, BDNF
4	Endothelin-1 Signaling Pathway36	11.2	BMP4, BMP5, BMP6, BMP7, IL10, IL13
5	DHA Signaling36	11.1	SERPINF1, BMP4, BMP5, BMP6, BMP7, BDNF
6	Pancreatic Adenocarcinoma36	11.0	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
7	Cellular Apoptosis Pathway36	11.0	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
8	NF-KappaB Family Pathway36	11.0	VAV2, VAV3, BMP4, BMP5, BMP6, BMP7
9	Mitochondrial Apoptosis36	10.9	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
10	PPAR Pathway36	10.9	BMP4, BMP5, IL2, IL6, IGF1R, IGF2
11	Apoptotic Pathways in Synovial Fibroblasts36	10.9	BMP4, BMP5, BMP6, BMP7, BDNF, IL2
12	Renin-Angiotensin Pathway36	10.9	REN, BMP4, BMP5, BMP6, BMP7, BDNF
13	p53 Mediated Apoptosis36	10.8	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
14	MAPK Signaling36	10.8	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
15	all-trans-Retinoic Acid Signaling in Brain36	10.8	BMP4, BMP5, BMP6, BMP7, BCL2, BAX
16	Nanog in Mammalian ESC Pluripotency36	10.8	BMP4, BMP5, BMP6, BMP7, BDNF, IL2
17	MIF Mediated Glucocorticoid Regulation36	10.7	BMP4, BMP5, BMP6, BMP7, BCL2, BAX
18	STAT3 Pathway36	10.7	BMP4, BMP5, BMP6, BMP7, BMPR2, BCL2
19	MIF Regulation of Innate Immune Cells36	10.7	BMP4, BMP5, BMP6, BMP7, BCL2, BAX
20	Phospholipase-C Pathway36	10.7	BMP4, BMP5, BMP6, BMP7, BDNF, LAMA3
21	14-3-3 Induced Intracellular Signaling36	10.7	BMP4, BMP5, BMP7, BDNF, MAPT, IGF1R
22	ILK Signaling36	10.7	NCK2, BMP4, BMP5, BMP7, BDNF, LAMA3
23	ERK Signaling36	10.7	BMP4, BMP5, BMP6, BMP7, PAX6, LAMA3
24	Glucocorticoid Receptor Signaling36	10.6	BMP4, BMP5, BMP6, BMP7, BCL2, BAX
25	JNK Pathway36	10.6	BMP4, BMP5, BMP6, BMP7, BCL2, BAX
26	Telomerase Components in Cell Signaling36	10.6	BMP4, BMP5, BMP6, BMP7, BDNF, IL2
27	p38 Signaling36	10.6	BMP4, BMP5, BMP6, BMP7, BMPR2, BDNF
28	Antioxidant Action of Vitamin-C36	10.6	BMP4, BMP5, BMP6, BMP7, BMPR2, BDNF
29	Toxoplasmosis20	10.6	BCL2, BCL2L1, LDLR, LAMA3, LAMB2, IL10
30	Cytokine-cytokine receptor interaction20	10.6	CNTF, VEGFA, BMP7, BMPR2, IL10, IL13
31	Glioma Invasiveness36	10.5	BMP4, BMP5, BMP6, BMP7, BDNF, PTK2
32	Estrogen Pathway36	10.5	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
33	ERK5 Signaling36	10.5	BMP4, BMP5, BMP6, BMP7, BDNF, IL2
34	Akt Signaling36	10.5	BMP4, BMP5, BMP7, BMPR2, IL10, IL18
35	IL-6 Pathway36	10.4	BMP4, BMP5, BMP6, BMP7, BAX, IL10
36	eIF2 Pathway36	10.4	BMP4, BMP5, BMP6, BMP7, BDNF, IL2
37	PAK Pathway36	10.4	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
38	Paxillin Interactions36	10.4	BMP4, BDNF, CTGF, NTRK1, LTBP2, LTBP3
39	MAPK Family Pathway36	10.4	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
40	Tec Kinases Signaling36	10.3	VAV2, VAV3, BMP4, BMP5, BMP6, BMP7
41	Rac1 Pathway36	10.3	BMP4, BMP5, BMP6, BMP7, BDNF, IL2
42	NF-KappaB (p50-p65) Pathway36	10.3	BMP4, BMP5, BMP6, BMP7, BDNF, UBC
43	TGF-Beta Pathway36	10.3	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
44	RAR-Gamma-RXR-Alpha Degradation36	10.2	BMP4, BMP5, BMP7, UBC, IL2, IL7
45	PEDF Induced Signaling36	10.2	SERPINF1, BMP4, BMP5, BMP6, BMP7, BDNF
46	PTEN Pathway36	10.2	BMP4, BMP5, BMP7, BDNF, LAMA3, LAMB2
47	Rheumatoid arthritis20	10.1	VEGFA, MMP1, MMP3, IL18, IL1A, IL1B
48	p70S6K Signaling36	10.0	BMP4, BMP5, BMP6, BMP7, BDNF, IL2
49	JAK-STAT Pathway36	10.0	BMP4, BMP5, BMP6, BMP7, BDNF, BCL2
50	Rho Family GTPases36	9.9	RDX, BMP4, BMP5, BMP6, BMP7, BDNF

Compounds related to glaucoma according to GeneDecks:

(show top 50)    (show all 502)

id	Compound	Score	Top Affiliating Genes
1	lipid32	14.1	RET, CNR1, CNTF, RDX, SELE, SERPINE1
2	estrogen32	13.8	VWF, RDX, SERPINE1, SERPINA3, BMP4, BMP7
3	retinoic acid32 42 18	15.0	RET, CNTF, VWF, GCNT2, SERPINF1, SERPINE1
4	oxygen32 18	13.8	SERPINF1, SERPINA3, CLU, PARP1, PAX6, BDNF
5	adenylate32	12.5	CNR1, CNTF, VWF, SELE, SERPINE1, BMP4
6	nitric oxide32 9 18 9	15.4	REN, CNTF, SELE, SERPINF1, BMP4, BMP6
7	sb 20358032 42	13.3	SELE, VEGFA, BMP4, BMP6, PARP1, BCL2
8	glucose32	12.2	CNTF, SERPINF1, BMP7, PAX6, BAK1, MT-ND4
9	pge232	12.1	REN, CNTF, SELE, BMP4, BMP7, LDLR
10	superoxide32 18	13.0	CNTF, SERPINA3, VCP, CLU, BAK1, MTR
11	norepinephrine32 9 18 9	14.9	REN, CNR1, CNTF, VWF, SELE, BMP6
12	aspirin32 34 18	13.8	CNR1, VWF, SELE, SERPINE1, BMP6, LDLR
13	cholesterol32 9 18 9	14.7	REN, VWF, SELE, SERPINE1, SERPINA3, CMA1
14	5fluorouracil32	11.7	SELE, VEGFA, BCL2, BCL2L1, MVP, MUC5AC
15	creatinine32	11.6	REN, VWF, SELE, SERPINA3, BMP6, BMP7
16	genistein32 9 18 9	14.6	RET, CNTF, SELE, SERPINE1, VEGFA, PARP1
17	homocysteine32 18	12.6	VWF, SELE, SERPINE1, MTRR, MTR, MTHFD1
18	curcumin32	11.4	VEGFA, PARP1, BCL2, BCL2L1, LDLR, BAK1
19	agar32	11.4	RET, CDH1, FN1, MIP, IL7, IGF1R
20	fluvastatin32 34 9 9	14.4	VWF, SERPINE1, LDLR, MMP1, MMP9, IL1A
21	agarose32	11.4	VWF, BMP7, CLU, PARP1, BCL2, BCL2L1
22	lactate32	11.3	VWF, SELE, BMP6, CLU, BDNF, MT-ND4
23	candesartan32 9 9	13.3	REN, SERPINE1, VEGFA, MMP1, MMP2, CCL2
24	ascorbic acid32 18	12.3	CNTF, MYOC, BMP4, BMP7, BDNF, LDLR
25	4-hydroxynonenal32 18	12.3	PARP1, BAX, MPO, MMP1, GSR, GSTM1
26	pravastatin32 34 9 18 9	15.3	SELE, SERPINE1, LDLR, GTF3A, IL18, IL6
27	simvastatin32 34 42 9 18 9	16.2	VWF, SELE, SERPINE1, VEGFA, BMP6, LDLR
28	estradiol32 9 18 9	14.2	REN, SERPINE1, SERPINA3, BDNF, BAK1, SAA1
29	quercetin32 42 9 18 9	15.1	SELE, PARP1, BCL2, BCL2L1, BAK1, BAX
30	c2ceramide32	11.1	PARP1, BCL2L1, BAX, IL1B, HSPB1, HSPA4
31	thymidylate32	11.0	VEGFA, BCL2, BCL2L1, MVP, BAX, MTRR
32	actinomycin d32	11.0	CNTF, SELE, SERPINE1, VEGFA, BMP4, CLU
33	tgf beta132	11.0	SERPINE1, BMP6, BMP7, CDKN1A, CDH1, MMP1
34	atenolol32 9 18 9	14.0	SERPINE1, CYP11B2, CYP2D6, ABCB1, ADRB2, ADRB1
35	bleomycin32 9 9	13.0	MVP, XRCC1, GSTM1, GSTP1, IL13, IL4
36	hyaluronic acid32 18	12.0	RDX, MYOC, BMP6, CDH1, MMP1, MMP3
37	calcitriol32 42 9 18 9	14.9	REN, BMP6, BMP7, CLU, BAK1, XPOT
38	paraffin32	10.9	RET, VWF, SERPINA3, VEGFA, CMA1, CLU
39	nmda32 42	11.9	CNR1, BDNF, BCL2L1, LDLR, GSR, IL1A
40	15-deoxy-delta-12,14-prostaglandin j232	10.8	SERPINE1, VEGFA, BMP6, BCL2L1, CDKN1A, IL10
41	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	10.7	PARP1, BCL2, BCL2L1, BAK1, BAX, MMP2
42	matrigel32	10.7	VWF, SELE, SERPINF1, SERPINE1, VEGFA, BMP6
43	melphalan32 9 9	12.7	BCL2L1, MVP, MMP2, GSTP1, IL4, IGF1R
44	acetylcholine32 9 18 9	13.6	CNR1, CNTF, VWF, SERPINA3, BMP6, BDNF
45	dopamine32 9 18 9	13.5	REN, RET, CNTF, SELE, SERPINA3, LMX1B
46	butyrate32	10.5	RET, BMP6, CLU, BCL2, BCL2L1, MVP
47	rantes32	10.3	SELE, BMP6, MMP1, MMP3, MMP9, IL10
48	infliximab32 9 9	12.2	SELE, VEGFA, BAK1, MMP1, MMP3, IL10
49	wortmannin32 42	10.9	RET, CNTF, BDNF, BCL2, BCL2L1, BAX
50	il 1032	9.8	BMP6, IL10, IL13, IL18, IL1A, IL1B

Cellular components related to glaucoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	12.2	IL1A, IL18, IL13, IL10, GREM1, MGP
2	plasma membrane	GO:005886	12.0	NOS3, RHO, RHOD, EDNRA, EDNRB, ABCA4
3	proteinaceous extracellular matrix	GO:005578	11.5	LTBP2, LTBP1, COL8A2, CTGF, SPARC, ELN
4	integral to plasma membrane	GO:005887	11.5	AGTR2, AGTR1, AGER, ABCC1, ABCA4, EDNRB
5	cell surface	GO:009986	11.4	CRYAB, NTRK2, NTRK1, DMD, TNFRSF1A, TNF
6	extracellular matrix	GO:031012	11.3	PLAT, COL8A1, COL8A2, LTBP1, LTBP2, TINAGL1
7	platelet alpha granule lumen	GO:031093	11.0	A2M, TIMP1, TGFB1, TGFB2, HGF, SPARC
8	basement membrane	GO:005604	10.8	TIMP2, TIMP1, COL8A2, COL8A1, SPARC, LOXL2
9	external side of plasma membrane	GO:009897	10.1	HLA-DRB1, TNF, ACE, TLR2, TLR4, THY1
10	membrane	GO:016020	9.4	ACHE, ABCC1, ABCB1, ABCA4, EDNRA, PLA2G6
11	extracellular region	GO:005576	INF	PGF, GDNF, EPO, HGF, HAMP, VWF
12	cytosol	GO:005829	INF	GJA1, TP53, DOCK11, PTK2, TBK1, DMD

Biological processes related to glaucoma according to GeneDecks:

(show top 50)    (show all 56)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	INF	AKR1B1, CYP11B2, CYP1B1, CYP26A1, CYP39A1, CA7
2	negative regulation of apoptotic process	GO:043066	12.0	SFRP1, ALB, HSPB1, HSPD1, CASP3, CAT
3	positive regulation of apoptotic process	GO:043065	12.0	TP53, TNF, NOS3, AGT, AGTR2, TLR4
4	negative regulation of cell proliferation	GO:008285	12.0	NOS3, SMAD2, NTRK1, TNF, TP53, AGT
5	aging	GO:007568	11.9	LOXL2, ERCC2, NR3C1, CRYAB, NOS3, EDNRA
6	response to hypoxia	GO:001666	11.8	EDN1, EDNRA, TLR4, TGFB1, TGFB2, PGF
7	heart development	GO:007507	11.7	GJA1, SPARC, SH3PXD2B, EDN1, EDNRA, TGFB2
8	blood coagulation	GO:007596	11.6	NOS2, PLAT, SPARC, PTK2, DOCK11, NOS3
9	negative regulation of cell growth	GO:030308	11.5	AGT, AGTR2, TGFB1, TGFB2, NPPA, NPR1
10	extracellular matrix organization	GO:030198	11.5	COL8A2, ELN, AGT, GFAP, TIMP1, TIMP2
11	blood vessel remodeling	GO:001974	11.5	TGM2, TGFB2, AGTR2, AGT, ELN, NOS3
12	positive regulation of cell proliferation	GO:008284	11.5	HRAS, PTK2, CTGF, NTRK2, EDN1, EDNRA
13	positive regulation of transcription from RNA polymerase II promoter	GO:045944	11.4	GDNF, ADRB2, SIX1, POMC, POU4F1, POU4F2
14	response to lipopolysaccharide	GO:032496	11.3	PTGER4, PTGFR, SPARC, EDN1, EDNRA, TLR4
15	response to estradiol stimulus	GO:032355	11.3	SLC6A1, BMP4, MMP9, ASS1, IL1B, ENO2
16	platelet degranulation	GO:002576	11.3	HGF, SOD1, TGFB2, TGFB1, TIMP1, A2M
17	regulation of blood pressure	GO:008217	11.3	SOD2, POMC, NPPA, NPR1, SOD1, AGTR2
18	kidney development	GO:001822	11.3	ACE, AGT, AGTR1, TGFB2, SIX1, CA2
19	platelet activation	GO:030168	11.3	PTK2, SPARC, A2M, TIMP1, TGFB1, TGFB2
20	angiogenesis	GO:001525	11.2	PTK2, CYP1B1, CTGF, NOS3, COL8A1, COL8A2
21	negative regulation of gene expression	GO:010629	11.2	TBK1, CRYAA, CRYAB, NOS2, HEY2, TNFRSF1A
22	response to drug	GO:042493	11.1	CDH1, MMP9, ASS1, IL10, IL1RN, IL4
23	positive regulation of protein phosphorylation	GO:001934	11.1	TGFB1, EDNRA, CRYAA, CTGF, PTK2, TNF
24	response to hyperoxia	GO:055093	11.1	EPO, NOS3, CAT, IL18, MMP9, CDKN1A
25	response to glucocorticoid stimulus	GO:051384	11.1	IL6, IL1RN, IL1B, IL10, SERPINE1, FAS
26	visual perception	GO:007601	11.1	RPGRIP1, WDR36, ABCA4, TYR, OPA1, OPN4
27	positive regulation of transcription, DNA-dependent	GO:045893	11.1	SMAD2, OTX2, TNF, TP53, ERCC2, PITX3
28	extracellular matrix disassembly	GO:022617	11.0	MMP1, MMP2, MMP3, MMP9, SH3PXD2B, TIMP1
29	cellular response to mechanical stimulus	GO:071260	11.0	TLR4, AGT, EDNRA, PTGER4, TNFRSF1A, FAS
30	positive regulation of inflammatory response	GO:050729	11.0	AGT, AGTR1, TLR2, TLR4, TGM2, EDNRA
31	release of cytochrome c from mitochondria	GO:001836	11.0	SOD2, TP53, CASP3, BAX, BAK1, BCL2L1
32	response to wounding	GO:009611	10.9	GFAP, TGFB1, TGFB2, SOX2, SLC1A3, ADORA3
33	response to ethanol	GO:045471	10.9	TNFRSF1A, SPARC, NOS3, TLR4, SOD1, CCL2
34	anti-apoptosis	GO:006916	10.8	BCL2, BCL2L1, UBC, MPO, GSTP1, IL10
35	positive regulation of branching involved in ureteric bud morphogenesis	GO:090190	10.8	GDNF, SIX1, TGFB1, AGTR2, AGT, GREM1
36	lipopolysaccharide-mediated signaling pathway	GO:031663	10.8	TGFB1, TLR4, TLR2, NOS3, TNF, CCL2
37	response to toxin	GO:009636	10.8	SLC6A1, PON1, TLR4, CYP1B1, CCL4, MBP
38	response to gamma radiation	GO:010332	10.8	TP53, BCL2, BAK1, BAX, IL1A, IL1B
39	negative regulation of neuron apoptotic process	GO:043524	10.7	SNCB, AGT, SOD1, SOD2, POU4F1, SIX1
40	regulation of mitochondrial membrane potential	GO:051881	10.7	HTT, BAX, BAK1, BCL2L1, BCL2, SOD1
41	cell-cell signaling	GO:007267	10.6	GJA1, ESR2, EDN1, AGT, TGFB2, POMC
42	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.5	EDNRB, EDN1, PITX2, SMAD2, HEY2, TGFB1
43	positive regulation of B cell proliferation	GO:030890	10.5	TLR4, IL7, IL5, IL4, IL2, IL13
44	immune response	GO:006955	10.4	CCR5, IGF1R, HLA-DQB1, HLA-DRB1, PTGER4, TLR2
45	inflammatory response	GO:006954	10.4	SPP1, TBK1, TNFRSF1A, TNF, IFNA2, CRP
46	ureteric bud development	GO:001657	10.4	GDF11, SIX1, TGFB1, SMAD2, BDNF, BMP7
47	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.4	AGER, AGT, TLR2, TLR4, TGFB1, NTRK1
48	bicarbonate transport	GO:015701	10.3	SLC4A4, SLC4A10, CA7, CA4, CA2, CA12
49	one-carbon metabolic process	GO:006730	10.1	CA7, CA4, CA2, CA12, CA9, CA6
50	eye development	GO:001654	INF	SOX2, TGFB2, SH3PXD2B, FOXC1, , PAX6

Molecular functions related to glaucoma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	16.0	EPO, OCRL, OGG1, OPTN, OPA1, PSMA7
2	protein heterodimerization activity	GO:046982	11.3	TLR2, TYRP1, TYR, AGTR1, TGFB1, TGFB2
3	heme binding	GO:020037	11.1	CYP2D6, CYP46A1, NOS2, NOS3, NGB, CYP39A1
4	cytokine activity	GO:005125	10.7	GDF11, IL1A, IL18, IL13, IL10, GREM1
5	extracellular matrix structural constituent	GO:005201	10.7	OPTC, PXDN, TINAGL1, ELN, COL8A2, FBN1
6	growth factor activity	GO:008083	10.4	GDNF, GDF11, IL5, IL4, IL2, IL1B
7	heparin binding	GO:008201	10.1	CCL2, GPNMB, CTGF, LTBP2, PGF, APOE
8	carbonate dehydratase activity	GO:004089	9.7	CA7, CA4, CA2, CA12, CA9, CA6
9	receptor binding	GO:005102	INF	CAV1, GJA1, NRG2, NOS2, TGFB2, POMC
10	protein homodimerization activity	GO:042803	INF	ACHE, SHBG, PITX2, NOS2, PLOD1, CRYAB