MCID: GLC007
MIFTS: 58

Glaucoma malady

Eye diseases category

Summaries for Glaucoma

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Glaucoma is a group of diseases that can damage the eye's optic nerve. it is a leading cause of blindness in the united states. it usually happens when the fluid pressure inside the eyes slowly rises, damaging the optic nerve. often there are no symptoms at first. without treatment, people with glaucoma will slowly lose their peripheral, or side vision. they seem to be looking through a tunnel. over time, straight-ahead vision may decrease until no vision remains. a comprehensive eye exam can tell if you have glaucoma. people at risk should get eye exams at least every two years. they include african americans over age 40 people over age 60, especially mexican americans people with a family history of glaucoma there is no cure, but glaucoma can usually be controlled. early treatment can help protect your eyes against vision loss. treatments usually include prescription eyedrops and/or surgery. nih: national eye institute

MalaCards: Glaucoma is related to open-angle glaucoma and primary open angle glaucoma. An important gene associated with Glaucoma is OPTN (optineurin). The drugs acetazolamide and carbachol and the compound coumarin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes.

Wikipedia:63 Glaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a... more...

Aliases & Classifications for Glaucoma

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Sources:
8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glaucoma family:

Juvenile Glaucoma Primary Congenital Glaucoma
Glaucoma Type 1c Glaucoma, Congenital
Cyp1b1-Related Primary Congenital Glaucoma Ltbp2-Related Primary Congenital Glaucoma
Early-Onset Glaucoma Glaucoma 3, Primary Congenital, D
Glaucoma 3, Primary Congenital, C

Diseases related to Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 464)
idRelated DiseaseScoreTop Affiliating Genes
1open-angle glaucoma31.9CYP1B1, MYOC, WDR36, OPTN
2primary open angle glaucoma31.7OPTN, MYOC, CYP1B1
3primary angle-closure glaucoma31.4MYOC
4ocular hypertension31.4MYOC, OPTN
5primary congenital glaucoma31.2CYP1B1
6aniridia30.7FOXC1
7primary open angle glaucoma juvenile onset 130.4MYOC, CYP1B1
8eye disease30.2FOXC1, OPTN, MYOC
9glaucoma 3, primary congenital, d30.2FOXC1, OPTN, MYOC, CYP1B1
10peters plus syndrome30.1CYP1B1, FOXC1
11axenfeld-rieger syndrome30.0FOXC1, CYP1B1
12optic nerve disease29.8OPTN, MYOC
13neovascular glaucoma11.0
14hypertension11.0
15retinitis10.8
16low tension glaucoma10.8
17juvenile glaucoma10.8
18cataract10.7
19exfoliation syndrome10.6
20phacolytic glaucoma10.5
21steroid-induced glaucoma - borderline10.5
22steroid-induced glaucoma10.5
23uveitis10.5
24myopia10.5
25neuropathy10.4
26choroiditis10.4
27retinal vein occlusion10.4
28traumatic glaucoma10.4
29central retinal vein occlusion10.4
30diabetic retinopathy10.4
31acute closed-angle glaucoma10.4
32ectropion10.3
33rubeosis iridis10.3
34melanoma10.3
35buphthalmos10.3
36endophthalmitis10.3
37keratitis10.3
38optic atrophy10.3
39scleritis10.3
40lens subluxation10.2
41ischemic neuropathy10.2
42retinal artery occlusion10.2
43retinal detachment10.2
44glaucoma 1, open angle, e10.2
45ischemic optic neuropathy10.2
46keratopathy10.2
47glaucoma 3 primary infantile b10.2
48megalocornea - spherophakia - secondary glaucoma10.2
49neurofibromatosis10.2
50chronic closed-angle glaucoma10.2

Graphical network of the top 20 diseases related to Glaucoma:



Diseases related to glaucoma

Clinical Features for Glaucoma

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Drugs & Therapeutics for Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Glaucoma

Drug clinical trials:

Search ClinicalTrials for Glaucoma

Search NIH Clinical Center for Glaucoma

Search CenterWatch for Glaucoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Glaucoma

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Glaucoma:

id Genetic test Affiliating Genes
1 Glaucoma20 22

Anatomical Context for Glaucoma

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Glaucoma:

32
Eye, Endothelial, Testes, Retina, Brain, Heart, Thyroid, Cortex, T cells, Tonsil, Bone marrow, Skin, Lung, Kidney, Bone, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Glaucoma:
id TissueAnatomical CompartmentCell Relevance
1 EyeGanglion Cell LayerMature Ganglion Cells Affected by disease

Animal Models for Glaucoma or affiliated genes

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Publications for Glaucoma

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Sources:
50PubMed
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Articles related to Glaucoma:

(show top 50)    (show all 3487)
idTitleAuthorsYear
1
Clinical Applicability of the International Classification of Disease and Related Health Problems (ICD-9) Glaucoma Staging Codes to Predict Disease Severity in Patients With Open-angle Glaucoma. (24370808)
2014
2
Combined cataract and glaucoma surgery: the effect of pupil enlargement on surgical outcomes (an american ophthalmological society thesis). (24385672)
2013
3
Discrimination of topiramate induced angle closure glaucoma from primary angle closure glaucoma: the triple of age, pattern of clinical presentation and drug history. (23433197)
2013
4
A Novel CYP1B1 Mutation with Congenital Glaucoma and Total Aniridia. (24001018)
2013
5
What do patients with glaucoma think about personal health records? (23919611)
2013
6
Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterization of the protein in the eye. (22714896)
2012
7
Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. (22394354)
2012
8
Effect of trabeculectomy on retrobulbar circulation and visual field progression in patients with primary open-angle glaucoma. (23055676)
2012
9
Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. (21684603)
2011
10
Comparison of fixed combinations of dorzolamide/timolol and brimonidine/timolol in patients with primary open-angle glaucoma. (22207522)
2011
11
Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma. (21199193)
2011
12
Anterior segment changes following intravitreal bevacizumab injection for treatment of neovascular glaucoma. (21629579)
2011
13
Is the GSTM1 null polymorphism a risk factor in primary open angle glaucoma? (21738397)
2011
14
Preliminary clinical analysis of neovascular glaucoma secondary to carotid artery disease. (21175823)
2011
15
First signs of glaucoma injury occur in the brain. What has generally been considered an eye disease is actually related to conditions such as Alzheimer's and Parkinson's diseases. (20518132)
2010
16
Efficacy and safety of fixed combinations of latanoprost/timolol and dorzolamide/timolol in open-angle glaucoma or ocular hypertension. (20019759)
2010
17
Association of CYP2D6 single-nucleotide polymorphism with response to ophthalmic timolol in primary open-angle Glaucoma--a pilot study. (20925579)
2010
18
Management of neovascular glaucoma with panretinal photocoagulation, intravitreal bevacizumab, and subsequent trabeculectomy with mitomycin C. (20179624)
2010
19
Primary congenital glaucoma associated with Patau syndrome with long survival. (21080618)
2010
20
Efficacy of Garcinia kola 0.5% Aqueous Eye Drops in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension. (20543944)
2010
21
Intravitreal bevacizumab combined with panretinal photocoagulation in the treatment of open angle neovascular glaucoma. (19882572)
2009
22
Neovascular glaucoma: etiology, diagnosis and prognosis. (19373696)
2009
23
A comparison of the intervisit intraocular pressure fluctuation after 180 and 360 degrees of selective laser trabeculoplasty (SLT) as a primary therapy in primary open angle glaucoma and ocular hypertension. (19225355)
2009
24
Potential diagnostic value of fluorescein angiography and color Doppler imaging in primary open angle glaucoma. (19882582)
2009
25
Characteristics of disc hemorrhage in primary angle-closure glaucoma. (18187197)
2008
26
A double-masked, randomized, parallel comparison of a fixed combination of bimatoprost 0.03%/timolol 0.5% with non-fixed combination use in patients with glaucoma or ocular hypertension. (17671954)
2007
27
Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States. (16505031)
2006
28
Central and paracentral corneal pachymetry in patients with normal tension glaucoma and ocular hypertension. (16075223)
2006
29
Trabeculectomy with mitomycin C combined with direct cauterization of peripheral iris in the management of neovascular glaucoma. (16988612)
2006
30
The European Glaucoma Prevention Study and the Ocular Hypertension Treatment Study: why do two studies have different results? (16552248)
2006
31
Molecular analysis of the myocilin gene in Chinese subjects with chronic primary-angle closure glaucoma. (15790895)
2005
32
Primary open angle glaucoma is associated with a specific p53 gene haplotype. (15060108)
2004
33
Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma. (14614750)
2003
34
Novel mutations in the MYOC/GLC1A gene in a large group of glaucoma patients. (12442283)
2002
35
Growth retardation, distinct oriental-like facies, glaucoma, brachydactyly, ventricular septal defect and speech disorder. An unknown entity. (10546095)
1999
36
Radiation-associated choroidal neovasculopathy, exudative detachment and neovascular glaucoma. A case report. (10670162)
1999
37
Novel mutations in the TIGR gene in early and late onset open angle glaucoma. (9521427)
1998
38
Day and night dysfunction in intraretinal melatonin and related indoleamines metabolism, correlated with the development of glaucoma-like disorder in an avian model. (9831262)
1998
39
Intraocular lens position and anterior chamber angle changes after cataract extraction in eyes with primary angle-closure glaucoma. (9379386)
1997
40
A gene for primary congenital glaucoma is not linked to the locus on chromosome 1q for autosomal dominant juvenile-onset open angle glaucoma. (8946299)
1996
41
Cataract extraction and intraocular lens implantation in eyes with phacomorphic or phacolytic glaucoma. (8784641)
1996
42
Use of scheimpflug photography to study iris configuration in patients with pigment dispersion syndrome and pigmentary glaucoma. (19920706)
1995
43
Neovascular glaucoma following neodymium-YAG laser posterior capsulotomy. (2423063)
1986
44
Sub scleral posterior sclerectomy in secondary glaucoma following perforated corneal ulcer. (6671794)
1983
45
Filtration surgery in the treatment of neovascular glaucoma. (6185899)
1982
46
Implants for draining neovascular glaucoma. (843508)
1977
47
Traumatic glaucoma--the thief of sight. (1152637)
1975
48
Iridectomy in primary angle-closure glaucoma. Classification and differential diagnosis of glaucoma associated with narrowness of the angle. (4810644)
1974
49
The etiology, diagnosis and treatment of juvenile glaucoma. (13278864)
1955
50
The surgical treatment of glaucoma complicating congenital aniridia. (13065371)
1953

Genetic Variations for Glaucoma

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Expression for genes affiliated with Glaucoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glaucoma

Search GEO for disease gene expression data for Glaucoma.

Pathways for genes affiliated with Glaucoma

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Compounds for genes affiliated with Glaucoma

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Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Glaucoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1coumarin44 2 49 2413.7ACHE, CYP1B1

GO Terms for genes affiliated with Glaucoma

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Products for genes affiliated with Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet