GLC1E
MCID: GLC062
MIFTS: 44

Glaucoma 1, Open Angle, E (GLC1E) malady

Categories: Genetic diseases (common), Eye diseases

Aliases & Classifications for Glaucoma 1, Open Angle, E

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Aliases & Descriptions for Glaucoma 1, Open Angle, E:

Name: Glaucoma 1, Open Angle, E 52 24 70 27 12 35 68
Primary Open Angle Glaucoma 35 11 24 50 13
Glaucoma, Primary Open Angle 70 27 39 68
Glc1e, Glaucoma, Primary Open Angle, Adult Onset 24
Glaucoma, Primary Open Angle, Adult-Onset 50
 
Adult-Onset Primary Open Angle Glaucoma 70
Primary Open Angle Glaucoma 1e 70
Chronic Simple Glaucoma 11
Glc1e 70
Poag 70

Characteristics:

HPO:

64
glaucoma 1, open angle, e:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM52 137760
Disease Ontology11 DOID:1070
ICD1030 H40.11
ICD9CM32 365.11
SNOMED-CT62 155122001, 77075001
NCIt45 C35394

Summaries for Glaucoma 1, Open Angle, E

About this section
OMIM:52 Quigley (1993) reviewed adult-onset primary open angle glaucoma, which combines a particular abnormal appearance of the... (137760) more...

MalaCards based summary: Glaucoma 1, Open Angle, E, also known as primary open angle glaucoma, is related to glaucoma, primary open angle, juvenile-onset, 2 and glaucoma 1a, primary open angle, and has symptoms including myopia and primary open angle glaucoma. An important gene associated with Glaucoma 1, Open Angle, E is OPTN (Optineurin), and among its related pathways is Elastic fibre formation. Affiliated tissues include eye.

UniProtKB/Swiss-Prot:70 Glaucoma 1, open angle, E: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Glaucoma, primary open angle: A complex and genetically heterogeneous ocular disorder characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. In some cases, POAG shows digenic inheritance involving mutations in CYP1B1 and MYOC genes.

Related Diseases for Glaucoma 1, Open Angle, E

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Diseases in the Glaucoma 1, Open Angle, G family:

Glaucoma 1, Open Angle, F glaucoma 1, open angle, e

Diseases related to Glaucoma 1, Open Angle, E via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma, primary open angle, juvenile-onset, 212.2
2glaucoma 1a, primary open angle12.0
3glaucoma 1, open angle, p11.9
4glaucoma 1, open angle, f11.8
5glaucoma 1, open angle, g11.8
6glaucoma 1, open angle, 1o11.8
7open-angle glaucoma11.6
8ocular hypertension10.8
9retinitis10.5
10primary angle-closure glaucoma10.5
11pituitary hormone deficiency, combined, 410.4CYP1B1, MYOC, OPTN
12baraitser-winter syndrome10.4CYP1B1, OPTN
13chronic tympanitis10.4CYP1B1, MYOC, OPTN
14mental retardation, autosomal dominant 3310.4ASB10, OPTN, WDR36
15opisthorchiasis10.4CYP1B1, MYOC, OPTN
16red-green color vision defects10.4CYP1B1, MYOC, WDR36
17peters anomaly10.4CYP1B1, MYOC, OPTN
18idiopathic corneal edema10.4CYP1B1, MYOC, OPTN
19mixed gonadal dysgenesis10.3OPTN, PHEX, TGFB2
20acquired hyperkeratosis10.3OPTN, PHEX
21acute poststreptococcal glomerulonephritis10.3CYP1B1, GSTM1, MYOC, OPTN
22emery-dreifuss muscular dystrophy 5, autosomal dominant10.3COCH, SIX1
23skin granular cell tumor10.3LOXL1, OPTN, PHEX
24nevoid hypermelanosis, linear and whorled10.3CYP1B1, MYOC, OPTN, WDR36
25olecranon bursitis10.3ELN, LOXL1, OPTN, PHEX
26pseudopterygium10.3LOXL1, OPTN, PHEX
27allergic contact dermatitis of eyelid10.3ELN, MYOC, OPTN, UBL4A
28mechanical strabismus10.3MYOC, OPTN, PHEX, UBL4A
29scapuloperoneal syndrome, myopathic type10.3ASB10, OPTN
30muir-torre syndrome10.3CYP1B1, MYOC, TGFB2
31schizencephaly10.3SIX1, SIX6
32conjunctival folliculosis10.3CYP1B1, OPTN
33myopia10.3
34cataract10.2
35endotheliitis10.2
36hereditary xanthinuria10.2CYP1B1, MYOC
37adult liposarcoma10.2ABCA4, MYOC, OPTN
38exfoliation syndrome10.2
39glaucoma, normal tension10.1
40morbid obesity and spermatogenic failure10.1CDKN2B-AS1, LOXL1, MYOC, OPTN, PHEX, UBL4A
41otofaciocervical syndrome10.1SIX1, SIX6
42hypertrophy of breast10.1CYP1B1, ELN, MYOC, OPTN, PHEX, TGFB2
43choroiditis10.1
44dementia10.0
45neuropathy10.0
46kearns-sayre syndrome9.9
47retinal vein occlusion9.9
48cerebritis9.9
49ocular hypotension9.9
50glaucomatocyclitic crisis9.9

Graphical network of the top 20 diseases related to Glaucoma 1, Open Angle, E:



Diseases related to glaucoma 1, open angle, e

Symptoms & Phenotypes for Glaucoma 1, Open Angle, E

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Symptoms by clinical synopsis from OMIM:

137760

Clinical features from OMIM:

137760

Human phenotypes related to Glaucoma 1, Open Angle, E:

 64
id Description HPO Frequency HPO Source Accession
1 myopia64 HP:0000545
2 primary open angle glaucoma64 HP:0012108

Drugs & Therapeutics for Glaucoma 1, Open Angle, E

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Drugs for Glaucoma 1, Open Angle, E (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 59)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TimololapprovedPhase 4, Phase 3, Phase 1, Phase 225226839-75-833624, 5478
Synonyms:
(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole
(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-timolol
131628-37-0
194288-09-0
26839-75-8
26921-17-5 (maleate (1:1) salt)
AB00513729
AC1L1PYN
AC1Q59QM
Apo-Timol
Apo-Timop
Aquanil
BIDD:GT0073
BPBio1_001008
BRD-K08806317-050-03-6
BSPBio_000916
Betim
Betimol
Betimol (TN)
Blocadren
C07141
C13H24N4O3S
CAS-26921-17-5
CHEBI:9599
CHEMBL499
CID33624
CPD001456519
D08600
DB00373
DB08625
EINECS 248-032-6
HMS2089I11
HSDB 6533
Istalol
L-714,465
LS-122231
Lopac-T-6394
Lopac0_001189
MK-950
NCGC00016038-01
 
NCGC00016038-02
NCGC00016798-01
NCGC00016798-07
NCGC00022033-02
NCGC00022033-04
NCGC00022033-05
Novo-Timol
Nu-Timolol
Oprea1_640981
Optimol
Phoxal-timolol
Prestwick0_000948
Prestwick1_000948
Prestwick2_000948
Prestwick3_000948
Proflax
S(-)-Timolol maleate
S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole
SAM002564238
SPBio_003075
ST072193
TIM
Temserin
Tenopt
Tim-AK
Timacar
Timacor
Timolol
Timolol (INN)
Timolol (TN)
Timolol GFS
Timolol Maleate, (1:1) Salt
Timolol [USAN]
Timolol anhydrous
Timolol maleate
Timololo
Timololum
Timololum [INN-Latin]
Timopic
Timoptic
Timoptic OcuDose
Timoptic in Ocudose
Timoptic-XE
Timoptol
Tocris-0649
UNII-817W3C6175
timolol
2
DorzolamideapprovedPhase 4, Phase 368120279-96-13154, 5284549
Synonyms:
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
(4S,6S)-4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
(4S,trans)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE
(4S-trans)-4-(ETHYLAMINO)-5,6-dihydro-6-methyl-4H-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide
120279-96-1
1cil
4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno[2,3-b]thiopyran-2-sulfonic acid amide
4S,6S-Dorzolamide
AB00514687
AC1NR4NP
BIDD:GT0306
BPBio1_001377
BRD-K48617017-003-03-1
BSPBio_001252
C06969
CHEBI:4702
 
CHEMBL218490
CID5284549
D07871
DB04507
Dorzolamid
Dorzolamida
Dorzolamide
Dorzolamide (DZA)
Dorzolamide (INN)
Dorzolamidum
HMS2089O06
MolPort-005-941-739
Prestwick0_001116
Prestwick1_001116
Prestwick2_001116
Prestwick3_001116
SPBio_003116
STK645522
Trusopt
Trusopt (TN)
dorzolamide
3
PilocarpineapprovedPhase 42754-71-7, 92-13-75910
Synonyms:
(+)-Pilocarpine
(3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
(3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
(3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
(3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone
(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone
3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one
3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone
3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydro-2(3H)-furanone
3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
54-71-7
91484-73-0
92-13-7
AC1L1J0W
AC1L1LEF
AC1Q6MOP
AI3-50523
AR-1F3128
Adsorbocarpine
Almocarpine
Amistura P
BIDD:GT0217
BPBio1_000548
BRD-K85090592-008-05-2
BSPBio_000498
BSPBio_002191
C07474
CHEBI:39460
CHEBI:8207
CHEMBL550
CID4819
CID5910
D00525
DB01085
DivK1c_000358
EINECS 202-128-4
Epicar
HMS2089K17
HSDB 3163
IDI1_000358
Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone
Isopto carpine
Isoptocarpine
KBio1_000358
KBio2_001587
KBio2_004155
KBio2_006723
KBio3_001691
KBioGR_000956
KBioSS_001587
L001181
LS-187208
LS-7661
Lopac0_000950
Lopac0_000960
Mi-Pilo
Minims Pilocarpine
Miocarpine
MolPort-002-512-506
NCGC00023339-03
 
NCGC00023339-06
NCGC00023339-07
NCGC00023339-08
NCGC00023339-09
NCGC00023339-12
NCGC00023339-13
NCI60_004403
NINDS_000358
NSC5746
Ocu-Carpine
Ocusert
Ocusert P 20
Ocusert Pilo-40
Ocusert pilo
Ocusert pilo-20
Ocusert pilo-20 (TN)
P.V. Carpine Liquifilm
Pilagan
Pilocarpin
Pilocarpine
Pilocarpine (JAN/USP)
Pilocarpine HCl
Pilocarpine Mononitrate, (3S-cis)-Isomer
Pilocarpine [USAN:BAN:JAN]
Pilocarpine chloride
Pilocarpine hydrochloride
Pilocarpine monohydrochloride
Pilocarpine muriate
Pilocarpine nitrate
Pilocarpine, Monohydrochloride, (3S-cis)-Isomer
Pilocarpol
Pilokarpin
Pilokarpin monohydrochloride
Pilokarpol
Piloptic-1
Piloptic-1/2
Piloptic-2
Piloptic-3
Piloptic-4
Piloptic-6
Pilostat
Prestwick0_000449
Prestwick1_000449
Prestwick2_000449
Prestwick3_000449
SDCCGMLS-0003164.P005
SPBio_001287
SPBio_002437
STOCK1N-18408
Salagen
Spectrum2_001284
Spectrum3_000546
Spectrum4_000478
Spectrum5_001379
Spectrum_001107
Spersacarpine
Spersacarpine hydrochloride
Syncarpine
Tocris-0694
UNII-01MI4Q9DI3
ZINC00075008
beta-Pilocarpine hydrochloride
isopilocarpine
nchembio.78-comp9
pilocarpine
4
BrinzolamideapprovedPhase 461138890-62-768844
Synonyms:
(+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide
(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide
138890-62-7
2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R
3znc
AB00513824
AC-5277
AC1L2AKA
AC1Q6UVB
AKOS005145708
AL 4862
AL-4862
AL04862
Alcon brand of brinzolamide
Allphar brand of brinzolamide
Azopt
Azopt (TN)
BIDD:GT0039
BPBio1_000539
BRD-K74913225-001-03-3
BSPBio_000489
BZ1
 
Birnzolamide
Brinzolamide
Brinzolamide (BRZ)
Brinzolamide (JAN/USP/INN)
Brinzolamide [USAN]
C07760
C111827
C12H21N3O5S3
CHEBI:3176
CHEMBL220491
CID68844
D00652
DB01194
FT-0082471
HMS1569I11
I09-0605
LS-173036
MLS002153787
MolPort-005-940-291
Prestwick0_000365
Prestwick1_000365
Prestwick2_000365
Prestwick3_000365
SMR001233169
SPBio_002410
UNII-9451Z89515
5
Latanoprostapproved, investigationalPhase 4, Phase 3, Phase 2, Phase 1198130209-82-45282380, 5311221
Synonyms:
130209-82-4
AC1NSK8Q
AR-202
Ambap130209-82-4
CHEBI:6384
CHEMBL1051
CID5311221
CPD000466354
Catioprost
D00356
HMS2051H11
HMS2089J17
Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
Jsp001835
L1167_SIGMA
Latanoprost
Latanoprost (JAN/USAN/INN)
Latanoprostum
MLS000759468
MLS001424106
 
MolPort-003-942-862
Nova-21027
PHXA-41
PhXA 41
PhXA34 [as 15(R,S)-isomer]
PhXA41
Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
S1254_Selleck
SAM001246671
SMR000466354
TL8000716
XA-41
XA41
Xalatan
Xalatan (TN)
Xalatan Fixed Flow Device
ZINC12468792
isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
latanoprost
latanoprost free acid
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
6
TravoprostapprovedPhase 4, Phase 2131157283-68-65282226
Synonyms:
(((1R)-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester
(+)-Fluprostenol isopropyl ester
(1R-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-Dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3R)-3-hydroxy-4-((alpha,alpha,alpha-trifluoro-m-isopropyl-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate
157283-68-6
5-Heptenoic acid,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-,1-methylethyl ester,(5Z)
AC-6103
AC1NQZOS
AL-6221
AL6221
C26H35F3O6
CHEBI:746859
CHEMBL1200799
CID5282226
D01964
DB00287
 
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1e,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
LS-173521
S1554_Selleck
Travatan
Travatan (TN)
Travatan Alcon
Travatan Z
Travatan, Travoprost
Travatanz
Travoprost
Travoprost (JAN/USAN/INN)
Travoprost [USAN]
Travoprostum
ZINC04474682
isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
7
Tobramycinapproved, investigationalPhase 412032986-56-45496, 36294
Synonyms:
1-Epitobramycin
11098-01-4
11111-45-8
3'-Deoxykanamycin B
3'-Deoxykanamycin b
32986-56-4
34337-51-4
37321-13-4
49842-07-1 (Sulfate)
54330-95-9
70322-33-7
79645-27-5
A 12253A
AB00513858
AC1L1KGY
AC1L1VI0
AC1O7GFJ
AC1Q2AOW
AKOS000715235
Aktob
BAS 00463364
BIDD:GT0503
BPBio1_000647
BRN 1357507
BSPBio_000587
BSPBio_002036
Brulamycin
C00397
C18H37N5O9
CAS-32986-56-4
CHEBI:28864
CHEBI:533587
CHEMBL1747
CID11340303
CID36294
CID5496
CID6604388
CID9804613
CID9934285
CPD000058793
D00063
DB00684
Deoxykanamycin B
Distobram
EINECS 251-322-5
Gotabiotic
HMS1569N09
HMS2090B16
HMS2092M17
HSDB 3259
KBio2_001552
KBio2_004120
KBio2_006688
KBio3_001536
KBioGR_001104
KBioSS_001552
LS-146940
LS-187329
Lilly 47663
MLS000069544
MolPort-001-934-131
MolPort-003-665-548
MolPort-003-939-629
NCGC00016814-01
NCGC00178852-01
NCGC00178852-02
NEBRAMYCIN
NF 6
NSC 180514
 
NSC180514
Nebcin
Nebcin (Sulfate)
Nebicin
Nebramycin 6
Nebramycin VI
Nebramycin factir 6
Nebramycin factor 6
Nebramycin-Faktor 6
O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine
Obracin
Obramycin
Prestwick0_000544
Prestwick1_000544
Prestwick2_000544
Prestwick3_000544
Prestwick_850
S2514_Selleck
SAM001246911
SMR000058793
SPBio_000295
SPBio_002508
SPECTRUM1500579
SPRC-AB01
STK182610
Spectrum2_000078
Spectrum3_000588
Spectrum4_000752
Spectrum5_001038
Spectrum_001072
Sybryx
T4014_SIGMA
TOA-(1-6)2TB-(4-1)TOC
TOA-(1-6)TOB-(4-1)TOC
TOBRAMYCIN SULFATE
TOY
Tenebrimycin
Tenemycin
Tobacin
Tobi
Tobracin
Tobracin (TN)
Tobracin (tn)
Tobradex
Tobradistin
Tobralex
Tobramaxin
Tobramicin
Tobramicina
Tobramicina [INN-Spanish]
Tobramitsetin
Tobramycetin
Tobramycin
Tobramycin (JP15/USP)
Tobramycin Sulfate
Tobramycin [USAN:BAN:INN:JAN]
Tobramycin for Inhalation
Tobramycin solution for inhalation
Tobramycin, Free Base
Tobramycine
Tobramycine [INN-French]
Tobramycinum
Tobramycinum [INN-Latin]
Tobrased
Tobrasone
Tobrex
Tobrex (TN)
Tobrex (tn)
UNII-VZ8RRZ51VK
tobramycin
tobramycin solution for inhalation
8
Dexamethasoneapproved, investigational, vet_approvedPhase 4217150-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
9
Trimethoprimapproved, vet_approvedPhase 4177738-70-55578
Synonyms:
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
46984_FLUKA
46984_RIEDEL
5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
738-70-5
92131_FLUKA
92131_SIGMA
AB00052118
AB1004879
AC-13572
AC1L1KNQ
AC1Q48DF
AI3-52594
AKOS001650069
ARONIS24118
AZT + TMP/SMX (mixture) combination
Abacin
Abaprim
Alcorim-F
Alprim
Anitrim
Antrima
Antrimox
Apo-Sulfatrim
BB_SC-2116
BIDD:GT0190
BPBio1_000215
BRD-K07208025-001-06-5
BRN 0625127
BSPBio_000195
BSPBio_002245
BW 56-72
BW 5672
BW-56-72
Bacdan
Bacidal
Bacide
Bacin
Bacta
Bacterial
Bacterial [Antibiotic]
Bacticel
Bactin
Bactoprim
Bactramin
Bactrim
Bactrim DS
Bactrim Pediatric
Baktar
Bencole
Bethaprim
Biosulten
Briscotrim
C01965
CAS-738-70-5
CCRIS 2410
CHEBI:45924
CHEMBL22
CID5578
CPD0-1581
CPD000035999
Chemotrim
Chemotrin
Cidal
Co-Trimoxizole
Co-trimoxazole
Colizole
Colizole DS
Comox
Conprim
Cotrim
Cotrim D.S.
Cotrimel
D00145
D014295
DB00440
Deprim
DivK1c_000589
Drylin
Duocide
EINECS 212-006-2
EU-0101271
Esbesul
Espectrin
Euctrim
Eusaprim
Exbesul
Fectrim
Fermagex
Fortrim
Futin
Gantaprim
Gantrim
HMS1568J17
HMS1921I03
HMS2090D14
HMS2092A10
HMS501N11
HSDB 6781
I06-0086
IDI1_000589
Idotrim
Ikaprim
Imexim
Instalac
Ipral
KBio1_000589
KBio2_000647
KBio2_003215
KBio2_005783
KBio3_001465
KBioGR_000863
KBioSS_000647
KSC-4-158
KUC103659N
Kepinol
Kombinax
LS-1627
Lagatrim
Lagatrim Forte
Laratrim
Lastrim
Lidaprim
Linaris
Lopac-T-7883
Lopac0_001271
MLS000079023
MLS001201740
MLS002303068
Methoprim
Metoprim
Microtrim
MolPort-001-826-685
Monoprim
Monotrim
Monotrimin
NCGC00016055-01
NCGC00016055-02
NCGC00016055-06
NCGC00016055-12
NCGC00024707-01
NCGC00024707-03
NCGC00024707-04
NCGC00024707-05
NCGC00024707-06
NCGC00024707-07
NCGC00024707-08
NIH 204
 
NIH 204 (VAN)
NINDS_000589
NSC 106568
NSC-106568
NSC106568
Nopil
Novotrimel
Omstat
Oprea1_495058
Oraprim
Pancidim
Polytrim
Prestwick0_000208
Prestwick1_000208
Prestwick2_000208
Prestwick3_000208
Prestwick_485
Priloprim
Primosept
Primsol
Proloprim
Proloprim (TN)
Protrin
Purbal
Resprim
Resprim Forte
Roubac
Roubal
SAM002264649
SMP2_000262
SMR000035999
SPBio_000874
SPBio_002116
SPECTRUM1500595
STK177322
Salvatrim
Septra
Septra DS
Septra Grape
Septrin
Septrin DS
Septrin Forte
Septrin S
Setprin
Sigaprim
Sinotrim
Smz-Tmp
Spectrum2_000937
Spectrum3_000643
Spectrum4_000372
Spectrum5_001559
Spectrum_000167
Stopan
Streptoplus
Sugaprim
Sulfamar
Sulfamethoprim
Sulfamethoprim-DS
Sulfamethoxazole & Trimethoprim
Sulfatrim
Sulfatrim Pediatric
Sulfatrim-DS
Sulfatrim-SS
Sulfotrim
Sulfoxaprim
Sulmeprim
Sulmeprim Pediatric
Sulprim
Sulthrim
Sultrex
Sumetrolim
Supracombin
Suprim
Syraprim
T 7883
T2286
T7883_SIGMA
TCMDC-125538
TL8005108
TMP/SMX (MIXTURE))
Teleprim
Thiocuran
Tiempe
Tmp-Ratiopharm
Tocris-0650
Toprim
Trigonyl
Trimanyl
Trimesulf
Trimeth/Sulfa
Trimethioprim
Trimethopim(TMP)
Trimethoprim
Trimethoprim & VRC3375
Trimethoprim (JAN/USP/INN)
Trimethoprim [USAN:BAN:INN:JAN]
Trimethoprime
Trimethoprime [INN-French]
Trimethoprimum
Trimethoprimum [INN-Latin]
Trimethopriom
Trimetoprim
Trimetoprim [DCIT]
Trimetoprim [Polish]
Trimetoprima
Trimetoprima [INN-Spanish]
Trimexazole
Trimexol
Trimez-IFSA
Trimezol
Trimogal
Trimono
Trimopan
Trimpex
Trimpex (TN)
Trimpex 200
Triméthoprime
Triprim
Trisul
Trisulcom
Trisulfam
Trisural
U-Prin
UNII-AN164J8Y0X
UPCMLD-DP132
UPCMLD-DP132:001
Unitrim
Uretrim
Uro-D S
Uro-Septra
Urobactrim
Uroplus
Uroplus DS
Uroplus SS
Utetrin
Velaten
WLN: T6N CNJ BZ DZ E1R CO1 DO1 EO1
WR 5949
Wellcoprim
Wellcoprin
Xeroprim
ZINC06627681
Zamboprim
component of Bactrim
component of Septra
nchembio.108-comp1
nchembio.215-comp11
nchembio.221-comp23
trimethoprim
10
Maleic acidexperimentalPhase 4, Phase 2296110-16-7444266
Synonyms:
(2Z)-2-Butenedioate
(2Z)-2-Butenedioic acid
(2Z)-Butene-2-dioate
(2Z)-Butene-2-dioic acid
(2Z)-but-2-enedioate
(2Z)-but-2-enedioic acid
(Z)-2-Butenedioate
(Z)-2-Butenedioic acid
(z)-butenedioate
(z)-butenedioic acid
2-Butenedioate
2-Butenedioic acid
Cis-butenedioate
Cis-butenedioic acid
 
H2male
Kyselina maleinova
MAE
Maleate
Maleic acid
Maleic acid [NA2215]
Maleinic acid
Malenic acid
Malezid CM
Scotchbond multipurpose etchant
Toxilic acid
cis-1,2-Ethylenedicarboxylic acid
cis-2-Butenedioate
cis-2-Butenedioic acid
cis-But-2-enedioate
cis-But-2-enedioic acid
11Peripheral Nervous System AgentsPhase 4, Phase 323689
12
FluticasonePhase 464490566-53-3, 80474-14-262924, 22833648
Synonyms:
90566-53-3
AC-456
AC1NSJZT
Asmatil
Axotide
BIDD:GT0819
Brethal
C07815
CHEMBL1201396
CID5311101
Cultivate
Cutivate
D07981
Flixonase
Flixonase Nasal Spray
Flixotide
Flixotide Disk
 
Flixotide Disks
Flixotide Inhaler
Flonase
Flovent
Flovent Diskus
Flovent Rotadisk
Fluinol
Flunase
Flusonal
Fluspiral
Fluticaps
Fluticaps (TN)
Fluticasone (INN)
Fluticasonpropionat Allen
Flutide
Flutivate
MolPort-006-666-449
S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
fluticasone
13Dermatologic AgentsPhase 45806
14Autonomic AgentsPhase 4, Phase 310150
15Respiratory System AgentsPhase 4, Phase 34997
16Cholinergic AgentsPhase 43992
17Adrenergic AgentsPhase 4, Phase 3, Phase 1, Phase 25352
18Anti-Inflammatory AgentsPhase 410729
19Adrenergic AgonistsPhase 4, Phase 23027
20Adrenergic beta-AntagonistsPhase 4, Phase 3, Phase 1, Phase 21193
21Bronchodilator AgentsPhase 42965
22Anti-Asthmatic AgentsPhase 43488
23Carbonic Anhydrase InhibitorsPhase 4, Phase 3186
24Brimonidine Tartrate, Timolol Maleate Drug CombinationPhase 424
25Brimonidine TartratePhase 4, Phase 212570359-46-5
26Anti-Arrhythmia AgentsPhase 4, Phase 3, Phase 1, Phase 23093
27Antihypertensive AgentsPhase 4, Phase 3, Phase 2, Phase 14207
28Neurotransmitter AgentsPhase 4, Phase 3, Phase 1, Phase 218340
29Adrenergic AntagonistsPhase 4, Phase 3, Phase 1, Phase 21573
30Adrenergic alpha-AgonistsPhase 4, Phase 21734
31Anti-Allergic AgentsPhase 41522
32Pharmaceutical SolutionsPhase 4, Phase 3, Phase 1, Phase 28192
33Ophthalmic SolutionsPhase 4, Phase 3, Phase 1, Phase 21140
34Adrenergic alpha-2 Receptor AgonistsPhase 4, Phase 2980
35HormonesPhase 414415
36Hormone AntagonistsPhase 413180
37Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 413168
38
protease inhibitorsPhase 45471
Synonyms:
 
protease inhibitors
39PolymyxinsPhase 462
40HIV Protease InhibitorsPhase 45470
41Polymyxin BPhase 449
42Antibiotics, AntitubercularPhase 47180
43Anti-Infective AgentsPhase 422062
44AntiemeticsPhase 44022
45glucocorticoidsPhase 45103
46Antineoplastic Agents, HormonalPhase 45592
47Anti-Bacterial AgentsPhase 411226
48BB 1101Phase 42171
49Dexamethasone acetatePhase 421711177-87-3
50Gastrointestinal AgentsPhase 48402

Interventional clinical trials:

(show all 27)
idNameStatusNCT IDPhase
1Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in CanadaCompletedNCT01415401Phase 4
2Comparison of Brimonidine Purite, Dorzolamide, and Brinzolamide as Adjunctive Therapy to Prostaglandin AnalogsCompletedNCT00675207Phase 4
3Inhaled Corticosteroids: Effect on Intraocular Pressure in Patients With Controlled GlaucomaCompletedNCT02338362Phase 4
4Dose, Effects and Characteristics of PilocarpineCompletedNCT00803803Phase 4
5Comparison of Combigan BID Versus Simbrinza TIDRecruitingNCT02167035Phase 4
6Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive AgentsActive, not recruitingNCT02873806Phase 4
7Efficacy of Changing to DuoTrav® (Travoprost 0.004%/Timolol 0.5% BAK-Free Fixed Combination) From Prior TherapyTerminatedNCT01514721Phase 4
8Equivalence Study of Dorzolamide 2% Eye Drops SolutionCompletedNCT00878917Phase 3
9Tafluprost-Timolol Fixed Dose Combination Non-Inferiority Study Against Concomitant AdministrationsCompletedNCT01306461Phase 3
10Safety and Efficacy of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular HypertensionRecruitingNCT02250651Phase 3
11Double-masked Study of PG324 Ophthalmic Solution in Patients With Glaucoma or Ocular HypertensionActive, not recruitingNCT02558400Phase 3
12A Study of Different Formulations of the L-PPDS in Subjects With OH or OAGCompletedNCT00967811Phase 2
13Safety and Efficacy of a New Ophthalmic Formulation of Bimatoprost in Patients With Open Angle Glaucoma and Ocular HypertensionCompletedNCT01157364Phase 1, Phase 2
14Study of Medical Treatment of Low-Pressure (Normal Tension) GlaucomaCompletedNCT00317577Phase 2
15Safety and Efficacy of ENV515 Travoprost Extended Release (XR) in Patients With Bilateral Ocular Hypertension or Primary Open Angle GlaucomaRecruitingNCT02371746Phase 2
16Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital GlaucomaUnknown statusNCT01460017Phase 1
17Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle GlaucomaRecruitingNCT03131167Phase 1
18Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma.RecruitingNCT02330978Phase 1
19Safety Study of Latanoprost Slow Release InsertTerminatedNCT01180062Phase 1
20Analysis of Clinical Profiles of Chinese Patients With Normal Tension GlaucomaUnknown statusNCT00321386
21Near to Infrared (NIR) Light Neuroprotection in Glaucomatous Optic NeuropathyUnknown statusNCT00844389Early Phase 1
22Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human EyeUnknown statusNCT01348672
23Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human EyeUnknown statusNCT01348633
24Spectral Domain Optical Coherence Tomography Analysis for GlaucomaCompletedNCT01612416
25Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma?CompletedNCT00312403
26Comparing the Effect of the Water Drinking Test on Intraocular PressureCompletedNCT02001155
27Multicentric Observational Study on Quality of Life in GlaucomaCompletedNCT01742104

Search NIH Clinical Center for Glaucoma 1, Open Angle, E

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Glaucoma 1, Open Angle, E cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Glaucoma 1, Open Angle, E:
Renexus
Embryonic/Adult Cultured Cells Related to Glaucoma 1, Open Angle, E:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926


Cochrane evidence based reviews: glaucoma, primary open angle

Genetic Tests for Glaucoma 1, Open Angle, E

About this section

Genetic tests related to Glaucoma 1, Open Angle, E:

id Genetic test Affiliating Genes
1 Primary Open Angle Glaucoma27
2 Primary Open Angle Glaucoma (adult Onset)27 24 WDR36
3 Glaucoma 1, Open Angle, E27 24 OPTN

Anatomical Context for Glaucoma 1, Open Angle, E

About this section

MalaCards organs/tissues related to Glaucoma 1, Open Angle, E:

36
Eye

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Glaucoma 1, Open Angle, E:
id TissueAnatomical CompartmentCell Relevance
1 EyeGanglion Cell LayerMature Ganglion Cells Affected by disease

Publications for Glaucoma 1, Open Angle, E

About this section

Variations for Glaucoma 1, Open Angle, E

About this section

UniProtKB/Swiss-Prot genetic disease variations for Glaucoma 1, Open Angle, E:

70 (show all 17)
id Symbol AA change Variation ID SNP ID
1CYP1B1p.Gly61GluVAR_001244rs28936700
2CYP1B1p.Trp57CysVAR_008350rs72549387
3CYP1B1p.Glu387LysVAR_008352rs55989760
4CYP1B1p.Tyr81AsnVAR_028736rs9282671
5CYP1B1p.Ser28TrpVAR_054227rs780002791
6CYP1B1p.Arg145TrpVAR_054235
7CYP1B1p.Glu229LysVAR_054243rs57865060
8CYP1B1p.Gly232ArgVAR_054244rs104893628
9CYP1B1p.Leu345PheVAR_054251rs66583685
10CYP1B1p.Val409PheVAR_054258
11CYP1B1p.Asn423TyrVAR_054260rs104893629
12CYP1B1p.Arg523ThrVAR_054267
13CYP1B1p.Asp530GlyVAR_054268
14OPTNp.His26AspVAR_021537
15OPTNp.Glu50LysVAR_021538rs28939688
16OPTNp.Glu103AspVAR_021540
17OPTNp.His486ArgVAR_021546

Clinvar genetic disease variations for Glaucoma 1, Open Angle, E:

5 (show all 11)
id Gene Variation Type Significance SNP ID Assembly Location
1LTBP2NM_ 000428.2(LTBP2): c.1484G> A (p.Arg495Gln)SNVLikely pathogenicrs137854858GRCh37Chr 14, 75017969: 75017969
2LTBP2NM_ 000428.2(LTBP2): c.4250A> G (p.Gln1417Arg)SNVLikely pathogenicrs137854863GRCh37Chr 14, 74971805: 74971805
3LTBP2NM_ 000428.2(LTBP2): c.4912G> A (p.Val1638Met)SNVLikely pathogenicrs137854860GRCh37Chr 14, 74969614: 74969614
4CARD10NM_ 014550.3(CARD10): c.635G> A (p.Arg212His)SNVrisk factorrs1057519378GRCh38Chr 22, 37516037: 37516037
5CARD10NM_ 014550.3(CARD10): c.983C> T (p.Ala328Val)SNVrisk factorrs139006752GRCh37Chr 22, 37904616: 37904616
6CARD10NM_ 014550.3(CARD10): c.1024G> A (p.Val342Met)SNVrisk factorrs200148764GRCh37Chr 22, 37904575: 37904575
7CARD10NM_ 014550.3(CARD10): c.1210C> T (p.Arg404Trp)SNVrisk factorrs750643216GRCh37Chr 22, 37902372: 37902372
8CARD10NM_ 014550.3(CARD10): c.2485C> T (p.Arg829Trp)SNVrisk factorrs201794655GRCh37Chr 22, 37888801: 37888801
9MYOCNM_ 000261.1(MYOC): c.1111T> C (p.Tyr371His)SNVPathogenicrs878854408GRCh38Chr 1, 171636329: 171636329
10OPTNNM_ 001008211.1(OPTN): c.293T> A (p.Met98Lys)SNVrisk factorrs11258194GRCh37Chr 10, 13152400: 13152400
11MYOCNM_ 000261.1(MYOC): c.1102C> T (p.Gln368Ter)SNVPathogenic/ Likely pathogenicrs74315329GRCh37Chr 1, 171605478: 171605478

Expression for genes affiliated with Glaucoma 1, Open Angle, E

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Search GEO for disease gene expression data for Glaucoma 1, Open Angle, E.

Pathways for genes affiliated with Glaucoma 1, Open Angle, E

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Pathways related to Glaucoma 1, Open Angle, E according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.1ELN, LOXL1, TGFB2

GO Terms for genes affiliated with Glaucoma 1, Open Angle, E

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Cellular components related to Glaucoma 1, Open Angle, E according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:003101210.6COCH, LOXL1, MYOC, TGFB2
2proteinaceous extracellular matrixGO:000557810.0COCH, ELN, LOXL1, MYOC

Biological processes related to Glaucoma 1, Open Angle, E according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1generation of neuronsGO:004869910.8SIX1, TGFB2
2visual perceptionGO:000760110.0ABCA4, CYP1B1, SIX6, WDR36

Sources for Glaucoma 1, Open Angle, E

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet