MCID: GLC062
MIFTS: 45

Glaucoma 1, Open Angle, E malady

Categories: Genetic diseases (common), Eye diseases

Aliases & Classifications for Glaucoma 1, Open Angle, E

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Aliases & Descriptions for Glaucoma 1, Open Angle, E:

Name: Glaucoma 1, Open Angle, E 49 11 22 67 24 32 65
Primary Open Angle Glaucoma 32 10 22 47 12
Glaucoma, Primary Open Angle 67 24 65
Glc1e, Glaucoma, Primary Open Angle, Adult Onset 22
Adult-Onset Primary Open Angle Glaucoma 67
 
Primary Open Angle Glaucoma 1e 67
Chronic Simple Glaucoma 10
Glc1e 67
Poag 67

Characteristics:

HPO:

61
glaucoma 1, open angle, e:
Inheritance: autosomal dominant inheritance


Classifications:



External Ids:

OMIM49 137760
Disease Ontology10 DOID:1070
ICD1027 H40.11
ICD9CM29 365.11
SNOMED-CT59 155122001, 77075001
NCIt42 C35394
UMLS65 C0339573, C1842026

Summaries for Glaucoma 1, Open Angle, E

About this section
OMIM:49 Quigley (1993) reviewed adult-onset primary open angle glaucoma, which combines a particular abnormal appearance of the... (137760) more...

MalaCards based summary: Glaucoma 1, Open Angle, E, also known as primary open angle glaucoma, is related to glaucoma 1a, primary open angle and glaucoma, primary open angle, juvenile-onset, 2, and has symptoms including primary open angle glaucomaand myopia. An important gene associated with Glaucoma 1, Open Angle, E is OPTN (Optineurin), and among its related pathways is Elastic fibre formation. Affiliated tissues include eye and testes, and related mouse phenotype vision/eye.

UniProtKB/Swiss-Prot:67 Glaucoma 1, open angle, E: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Glaucoma, primary open angle: A complex and genetically heterogeneous ocular disorder characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. In some cases, POAG shows digenic inheritance involving mutations in CYP1B1 and MYOC genes.

Related Diseases for Glaucoma 1, Open Angle, E

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Diseases in the Glaucoma 1, Open Angle, G family:

Glaucoma 1, Open Angle, F glaucoma 1, open angle, e

Diseases related to Glaucoma 1, Open Angle, E via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 516)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma 1a, primary open angle34.4CYP1B1, MYOC, OPTN
2glaucoma, primary open angle, juvenile-onset, 212.7
3glaucoma 1, open angle, f12.2
4glaucoma 1, open angle, p12.1
5glaucoma 1, open angle, g12.0
6glaucoma 1, open angle, 1o12.0
7open-angle glaucoma11.1
8leukemia10.7
9endotheliitis10.7
10lymphoma10.6
11thyroiditis10.6
12colorectal cancer 510.6NAP1L1, OPTN
13adams-oliver syndrome10.6CYP1B1, OPTN
14acute contagious conjunctivitis10.6CYP1B1, OPTN
15hepatitis10.5
16prostatitis10.5
17pancreatitis10.5
18essential pentosuria10.5CYP1B1, MYOC
19hydrophthalmos10.5CYP1B1, MYOC, OPTN
20glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.5CYP1B1, MYOC, OPTN
21lung cancer10.5
22breast cancer10.5
23obesity10.5
24esophagitis10.5
25cerebritis10.5
26cardiomyopathy10.5
27bullous keratopathy10.5CYP1B1, MYOC, OPTN
28optic atrophy plus syndrome10.5LOXL1, NAP1L1, OPTN
29primary familial brain calcification10.5CYP1B1, MYOC, WDR36
30gonadal dysgenesis10.5MYOC, OPTN, TGFB2
31neuroendocrine tumor10.5OPTN, TGFB2
32neonatal thyrotoxicosis10.5ELN, LOXL1, OPTN
33melanoma10.5
34cervicitis10.5
35retinitis10.5
36hypoxia10.5
37visual pathway disease10.5OPTN, SIX1
38priapism10.4MYOC, OPTN, UBL4A
39paraurethral gland cancer10.4CYP1B1, GSTM1, MYOC, OPTN
40night blindness, congenital stationary , 1d, autosomal recessive10.4ELN, GSTM1, LOXL1
41embryonal testis carcinoma10.4ABCA4, MYOC, OPTN
42prostate cancer10.4
43hepatocellular carcinoma10.4
44myelodysplastic syndrome10.4
45multiple myeloma10.4
46myeloma10.4
47portal hypertension10.4
48pneumonia10.4
49herpes simplex10.4
50ataxia10.4

Graphical network of the top 20 diseases related to Glaucoma 1, Open Angle, E:



Diseases related to glaucoma 1, open angle, e

Symptoms for Glaucoma 1, Open Angle, E

About this section

Symptoms by clinical synopsis from OMIM:

137760

Clinical features from OMIM:

137760

HPO human phenotypes related to Glaucoma 1, Open Angle, E:

id Description Frequency HPO Source Accession
1 primary open angle glaucoma HP:0012108
2 myopia HP:0000545

Drugs & Therapeutics for Glaucoma 1, Open Angle, E

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Drugs for Glaucoma 1, Open Angle, E (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PilocarpineapprovedPhase 42454-71-75910
Synonyms:
(+)-Pilocarpine
(3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
(3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
(3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
(3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone
(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone
3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one
3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone
3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydro-2(3H)-furanone
3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
54-71-7
91484-73-0
92-13-7
AC1L1J0W
AC1L1LEF
AC1Q6MOP
AI3-50523
AR-1F3128
Adsorbocarpine
Almocarpine
Amistura P
BIDD:GT0217
BPBio1_000548
BRD-K85090592-008-05-2
BSPBio_000498
BSPBio_002191
C07474
CHEBI:39460
CHEBI:8207
CHEMBL550
CID4819
CID5910
D00525
DB01085
DivK1c_000358
EINECS 202-128-4
Epicar
HMS2089K17
HSDB 3163
IDI1_000358
Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone
Isopto carpine
Isoptocarpine
KBio1_000358
KBio2_001587
KBio2_004155
KBio2_006723
KBio3_001691
KBioGR_000956
KBioSS_001587
L001181
LS-187208
LS-7661
Lopac0_000950
Lopac0_000960
Mi-Pilo
Minims Pilocarpine
Miocarpine
MolPort-002-512-506
NCGC00023339-03
NCGC00023339-06
 
NCGC00023339-07
NCGC00023339-08
NCGC00023339-09
NCGC00023339-12
NCGC00023339-13
NCI60_004403
NINDS_000358
NSC5746
Ocu-Carpine
Ocusert
Ocusert P 20
Ocusert Pilo-40
Ocusert pilo
Ocusert pilo-20
Ocusert pilo-20 (TN)
P.V. Carpine Liquifilm
Pilagan
Pilocarpin
Pilocarpine
Pilocarpine (JAN/USP)
Pilocarpine HCl
Pilocarpine Hydrochloride
Pilocarpine Mononitrate, (3S-cis)-Isomer
Pilocarpine [USAN:BAN:JAN]
Pilocarpine chloride
Pilocarpine hydrochloride
Pilocarpine monohydrochloride
Pilocarpine muriate
Pilocarpine nitrate
Pilocarpine, Monohydrochloride, (3S-cis)-Isomer
Pilocarpol
Pilokarpin
Pilokarpin monohydrochloride
Pilokarpol
Piloptic-1
Piloptic-1/2
Piloptic-2
Piloptic-3
Piloptic-4
Piloptic-6
Pilostat
Prestwick0_000449
Prestwick1_000449
Prestwick2_000449
Prestwick3_000449
SDCCGMLS-0003164.P005
SPBio_001287
SPBio_002437
STOCK1N-18408
Salagen
Spectrum2_001284
Spectrum3_000546
Spectrum4_000478
Spectrum5_001379
Spectrum_001107
Spersacarpine
Spersacarpine hydrochloride
Syncarpine
Tocris-0694
UNII-01MI4Q9DI3
ZINC00075008
beta-Pilocarpine hydrochloride
isopilocarpine
nchembio.78-comp9
pilocarpine
2
BrinzolamideapprovedPhase 459138890-62-768844
Synonyms:
(+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide
(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide
138890-62-7
2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R
3znc
AB00513824
AC-5277
AC1L2AKA
AC1Q6UVB
AKOS005145708
AL 4862
AL-4862
AL04862
Alcon brand of brinzolamide
Allphar brand of brinzolamide
Azopt
Azopt (TN)
BIDD:GT0039
BPBio1_000539
BRD-K74913225-001-03-3
BSPBio_000489
BZ1
 
Birnzolamide
Brinzolamide
Brinzolamide (BRZ)
Brinzolamide (JAN/USP/INN)
Brinzolamide [USAN]
C07760
C111827
C12H21N3O5S3
CHEBI:3176
CHEMBL220491
CID68844
D00652
DB01194
FT-0082471
HMS1569I11
I09-0605
LS-173036
MLS002153787
MolPort-005-940-291
Prestwick0_000365
Prestwick1_000365
Prestwick2_000365
Prestwick3_000365
SMR001233169
SPBio_002410
UNII-9451Z89515
3
TimololapprovedPhase 4, Phase 3, Phase 2, Phase 123626839-75-833624, 5478
Synonyms:
(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole
(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-timolol
131628-37-0
194288-09-0
26839-75-8
26921-17-5 (maleate (1:1) salt)
AB00513729
AC1L1PYN
AC1Q59QM
Apo-Timol
Apo-Timop
Aquanil
BIDD:GT0073
BPBio1_001008
BRD-K08806317-050-03-6
BSPBio_000916
Betim
Betimol
Betimol (TN)
Blocadren
C07141
C13H24N4O3S
CAS-26921-17-5
CHEBI:9599
CHEMBL499
CID33624
CPD001456519
D08600
DB00373
DB08625
EINECS 248-032-6
HMS2089I11
HSDB 6533
Istalol
L-714,465
LS-122231
Lopac-T-6394
Lopac0_001189
MK-950
NCGC00016038-01
NCGC00016038-02
 
NCGC00016798-01
NCGC00016798-07
NCGC00022033-02
NCGC00022033-04
NCGC00022033-05
Novo-Timol
Nu-Timolol
Oprea1_640981
Optimol
Phoxal-timolol
Prestwick0_000948
Prestwick1_000948
Prestwick2_000948
Prestwick3_000948
Proflax
S(-)-Timolol maleate
S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole
SAM002564238
SPBio_003075
ST072193
TIM
Temserin
Tenopt
Tim-AK
Timacar
Timacor
Timolol
Timolol (INN)
Timolol (TN)
Timolol GFS
Timolol Maleate
Timolol Maleate, (1:1) Salt
Timolol [USAN]
Timolol hemihydrate
Timolol maleate
Timololo
Timololum
Timololum [INN-Latin]
Timopic
Timoptic
Timoptic OcuDose
Timoptic in Ocudose
Timoptic-XE
Timoptic-xe
Timoptol
Tocris-0649
UNII-817W3C6175
timolol
4
DorzolamideapprovedPhase 4, Phase 364120279-96-13154, 5284549
Synonyms:
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
(4S,6S)-4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
(4S,trans)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
(4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE
(4S-trans)-4-(ETHYLAMINO)-5,6-dihydro-6-methyl-4H-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide
120279-96-1
1cil
4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno[2,3-b]thiopyran-2-sulfonic acid amide
4S,6S-Dorzolamide
AB00514687
AC1NR4NP
BIDD:GT0306
BPBio1_001377
BRD-K48617017-003-03-1
BSPBio_001252
C06969
CHEBI:4702
 
CHEMBL218490
CID5284549
D07871
DB04507
Dorzolamid
Dorzolamida
Dorzolamide
Dorzolamide (DZA)
Dorzolamide (INN)
Dorzolamide Hydrochloride
Dorzolamidum
HMS2089O06
MolPort-005-941-739
Prestwick0_001116
Prestwick1_001116
Prestwick2_001116
Prestwick3_001116
SPBio_003116
STK645522
Trusopt
Trusopt (TN)
dorzolamide
5
Latanoprostapproved, investigationalPhase 4, Phase 2, Phase 1184130209-82-45282380, 5311221
Synonyms:
130209-82-4
AC1NSK8Q
AR-202
Ambap130209-82-4
CHEBI:6384
CHEMBL1051
CID5311221
CPD000466354
Catioprost
D00356
HMS2051H11
HMS2089J17
Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
Jsp001835
L1167_SIGMA
Latanoprost
Latanoprost (JAN/USAN/INN)
Latanoprostum
MLS000759468
MLS001424106
 
MolPort-003-942-862
Nova-21027
PHXA-41
PhXA 41
PhXA34 [as 15(R,S)-isomer]
PhXA41
Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
S1254_Selleck
SAM001246671
SMR000466354
TL8000716
XA-41
XA41
Xalatan
Xalatan (TN)
Xalatan Fixed Flow Device
ZINC12468792
isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
latanoprost
latanoprost free acid
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
6
TravoprostapprovedPhase 4127157283-68-65282226
Synonyms:
(((1R)-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester
(+)-Fluprostenol isopropyl ester
(1R-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-Dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3R)-3-hydroxy-4-((alpha,alpha,alpha-trifluoro-m-isopropyl-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate
157283-68-6
5-Heptenoic acid,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-,1-methylethyl ester,(5Z)
AC-6103
AC1NQZOS
AL-6221
AL6221
C26H35F3O6
CHEBI:746859
CHEMBL1200799
CID5282226
D01964
DB00287
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1e,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
 
Izba
LS-173521
S1554_Selleck
Travatan
Travatan (TN)
Travatan Alcon
Travatan Z
Travatan, Travoprost
Travatanz
Travoprost
Travoprost (JAN/USAN/INN)
Travoprost Ophthalmic Solution 0.004%
Travoprost [USAN]
Travoprostum
ZINC04474682
isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
7
Maleic acidexperimentalPhase 4274110-16-7444972, 444266
Synonyms:
(2Z)-2-Butenedioate
(2Z)-2-Butenedioic acid
(2Z)-Butene-2-dioate
(2Z)-Butene-2-dioic acid
(2Z)-but-2-enedioate
(2Z)-but-2-enedioic acid
(Z)-2-Butenedioate
(Z)-2-Butenedioic acid
(z)-butenedioate
(z)-butenedioic acid
2-Butenedioate
2-Butenedioic acid
Cis-butenedioate
Cis-butenedioic acid
 
H2male
Kyselina maleinova
MAE
Maleate
Maleic acid
Maleic acid [NA2215]
Maleinic acid
Malenic acid
Malezid CM
Scotchbond multipurpose etchant
Toxilic acid
cis-1,2-Ethylenedicarboxylic acid
cis-2-Butenedioate
cis-2-Butenedioic acid
cis-But-2-enedioate
cis-But-2-enedioic acid
8Anti-Asthmatic AgentsPhase 42796
9Anti-Allergic AgentsPhase 41312
10Adrenergic AgentsPhase 4, Phase 3, Phase 2, Phase 14204
11Bronchodilator AgentsPhase 42377
12Respiratory System AgentsPhase 4, Phase 33931
13
FluticasonePhase 458990566-53-3, 80474-14-262924, 22833648
Synonyms:
90566-53-3
AC-456
AC1NSJZT
Asmatil
Axotide
BIDD:GT0819
Brethal
C07815
CHEMBL1201396
CID5311101
Cultivate
Cutivate
D07981
Flixonase
Flixonase Nasal Spray
Flixotide
Flixotide Disk
 
Flixotide Disks
Flixotide Inhaler
Flonase
Flovent
Flovent Diskus
Flovent Rotadisk
Fluinol
Flunase
Flusonal
Fluspiral
Fluticaps
Fluticaps (TN)
Fluticasone (INN)
Fluticasonpropionat Allen
Flutide
Flutivate
MolPort-006-666-449
S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
fluticasone
14Dermatologic AgentsPhase 44555
15Cholinergic AgentsPhase 43243
16Anti-Inflammatory AgentsPhase 48478
17Peripheral Nervous System AgentsPhase 4, Phase 318510
18Antihypertensive AgentsPhase 4, Phase 3, Phase 2, Phase 13618
19Brimonidine TartratePhase 4, Phase 211670359-46-5
20Pharmaceutical SolutionsPhase 4, Phase 3, Phase 1, Phase 27004
21Adrenergic beta-AntagonistsPhase 4, Phase 3, Phase 1, Phase 2979
22Adrenergic AntagonistsPhase 4, Phase 3, Phase 1, Phase 21253
23Carbonic Anhydrase InhibitorsPhase 4, Phase 3153
24Anti-Arrhythmia AgentsPhase 4, Phase 3, Phase 1, Phase 22371
25Neurotransmitter AgentsPhase 4, Phase 3, Phase 2, Phase 114795
26Adrenergic alpha-AgonistsPhase 4, Phase 21300
27Ophthalmic SolutionsPhase 4, Phase 3, Phase 1, Phase 21006
28Adrenergic AgonistsPhase 4, Phase 22331
29Adrenergic alpha-2 Receptor AgonistsPhase 4, Phase 2790
30
PseudoephedrineapprovedPhase 344790-82-47028
Synonyms:
( )-Pseudoephedrine
(+)-(1S,2S)-Pseudoephedrine
(+)-Pseudoephedrine
(+)-Psi-ephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(1S,2S)-(+)-Pseudoephedrine
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
(1S,2S)-2-Methylamino-1-phenyl-1-propanol
(1S,2S)-Pseudoephedrine
(1S,2S)-Pseudoephedrine, polymer-bound
1-Ephedrine
2-(Methylamino)-1-phenyl-1-propanol
287636_ALDRICH
304-87-0
30987-59-8
37577-31-4
649031_ALDRICH
90-82-4
AC-20292
AC1L1NUA
Acunaso
Acunaso (TN)
Afrinol
BIDD:GT0817
BRD-K84175871-003-02-2
BSPBio_003261
Balminil Decongestant Syrup
Benylin Decongestant
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)- (9CI)
Besan
C02765
C10H15NO
CHEBI:51209
CHEMBL1590
CID7028
CPD-9954
Cenafed
D-Isoephedrine
D-Pseudoephedrine
D-Pseudoephedrine base
D-Psi-2-Methylamino-1-phenyl-1-propanol
D-Psi-2-methylamino-1-phenyl-1-propanol
D-Psi-Ephedrine
D-Psi-ephedrine
D08449
DB00852
Decofed
Dimetapp Decongestant
Dimetapp Decongestant Pediatric Drops
DivK1c_000451
Drixoral N.D.
Drixoral Nasal Decongestant
EINECS 202-018-6
Efidac 24 Pseudoephedrine Hcl
Efidac/24
Eltor 120
Ephed 60
Ephedrine
Genaphed
HSDB 3177
I01-8928
IDI1_000451
Isoephedrine
KBio1_000451
 
KBio2_001358
KBio2_003926
KBio2_006494
KBio3_002762
KBioGR_001763
KBioSS_001358
L(+)-Psi-Ephedrine
L(+)-Psi-ephedrine
L(+)-psi-Ephedrine
L-(+)-Pseudoephedrine
LS-125922
Lopac-E-3250
Maxenal
MolPort-001-684-474
Myfedrine
NCGC00015408-01
NCGC00178180-01
NCI60_002955
NINDS_000451
Neodurasina
Neodurasina (TN)
Novafed
PDSP1_001347
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoefedrina [INN-Spanish]
Pseudoephedrine
Pseudoephedrine (D)
Pseudoephedrine (INN)
Pseudoephedrine D-form
Pseudoephedrine Ephedrine
Pseudoephedrine Hydrochloride
Pseudoephedrine [INN:BAN]
Pseudoephedrine d-form
Pseudoephedrine hydrochloride
Pseudoephedrine sulfate
Pseudoephedrinum
Pseudoephedrinum [INN-Latin]
Psi-ephedrin
Psi-ephedrine
Robidrine
SPBio_001365
STOCK1N-42675
Spectrum2_001303
Spectrum3_001771
Spectrum4_001162
Spectrum5_000650
Spectrum_000878
Sudafed
Sudafed Decongestant
Sudafed Decongestant 12 Hour
Sudafed Decongestant Extra Strength
Suphedrine
Triaminic AM Decongestant Formula
Triaminic Infant Oral Decongestant Drops
UNII-7CUC9DDI9F
alpha-(1-(Methylamino)ethyl)benzyl alcohol
d-Isoephedrine
d-Pseudoephedrine
d-psi-2-Methylamino-1-phenyl-1-propanol
d-psi-Ephedrine
trans-Ephedrine
31
EphedrineapprovedPhase 3447299-42-39294
Synonyms:
( )-Pseudoephedrine
(+)-Ephedrin
(+)-Ephedrine
(+)-Pseudoephedrine
(+)-psi-Ephedrine
(+)-threo-Ephedrine
(+-)-Ephedrine
(-)-Ephedrine
(-)-Pseudoephedrine
(-)-psi-Ephedrine
(-)-threo-Ephedrine
(1R,2R)-Ephedrine
(1R,2S)-1-Phenyl-1-hydroxy-2-methylaminopropane
(1S,2R)-Ephedrine
(L)-EPHEDRINE
--EPHEDRINE
1-EPHEDRINE
1-Sedrin
134910_ALDRICH
287636_ALDRICH
287644_ALDRICH
299-42-3
304-87-0
30987-59-8
321-96-0
321-97-1
321-98-2
37577-31-4
38732-95-5
45261_FLUKA
4607-45-8
50-98-6
50906-05-3
53214-57-6
649031_ALDRICH
6912-63-6
7009-81-6
90-82-4
968-63-8
AC-20231
AC-20292
AC1L1JGK
AC1L1NUA
AC1L1RFA
AC1L1SR1
AC1L1T31
AC1L1Y3M
AC1O8JUO
AC1Q3XJE
AC1Q3XJM
AC1Q3XJN
AC1Q59F5
AC1Q7701
AI3-02761
AKOS000268842
AR-1A0126
AR-1I7143
Acunaso
Acunaso (TN)
Afrinol
Ambap299-42-3
BIDD:GT0817
BRN 3197916
BRN 4231286
BSPBio_001946
BSPBio_001968
BSPBio_003261
Benylin Decongestant
Besan
Biophedrin
C01575
C02765
C10H15NO
CHEBI:15407
CHEBI:51209
CHEMBL1590
CHEMBL211456
CHEMBL357080
CID11972440
CID5032
CID62946
CID6710657
CID7028
CID8650
CID9294
CID9457
CPD-9954
CPDD 0049
Cenafed
D00124
D08449
DB00852
DB01364
Decofed
DivK1c_000181
DivK1c_000451
DivK1c_000461
Drixoral N.D.
EINECS 202-017-0
EINECS 202-018-6
EINECS 206-080-5
EINECS 206-292-8
EINECS 206-293-3
Eciphin
Efedrin
Efidac/24
Eltor 120
Ephedral
Ephedremal
Ephedrin
Ephedrine
Ephedrine (TN)
Ephedrine (USP)
Ephedrine [USAN:BAN]
Ephedrine l-form
Ephedrital
Ephedrol
Ephedrosan
Ephedrotal
Ephedsol
Ephendronal
Ephoxamin
Fedrin
Genaphed
HSDB 3072
HSDB 3177
I-Sedrin
I01-3584
I01-8925
I01-8928
 
IDI1_000181
IDI1_000451
IDI1_000461
Isoephedrine
Jsp005664
KBio1_000181
KBio1_000451
KBio1_000461
KBio2_001358
KBio2_001500
KBio2_003926
KBio2_004068
KBio2_006494
KBio2_006636
KBio3_001188
KBio3_001446
KBio3_002762
KBioGR_001013
KBioGR_001763
KBioSS_001358
KBioSS_001500
KST-1A9168
Kratedyn
L(+)-psi-Ephedrine
L(-)-Ephedrine
L-(+)-Ephedrine
L-(-)-Ephedrine
L-Ephedrine
L-erythro-2-(Methylamino)-1-phenylpropan-1-ol
L000968
LS-125921
LS-125922
LS-43083
LS-63961
LS-63962
LS-63963
LS-63964
Lexofedrin
Lopac-E-3250
Lopac0_000501
MLS000069657
Manadrin
Mandrin
Maxenal
MolPort-001-684-474
MolPort-001-684-477
MolPort-001-684-478
MolPort-001-684-479
MolPort-001-769-085
Myfedrine
NCGC00015408-01
NCGC00015408-02
NCGC00162174-01
NCGC00178180-01
NCGC00178889-01
NCI-C55652
NCI60_002955
NINDS_000181
NINDS_000451
NINDS_000461
NSC 165609
NSC 170951
NSC 8971
NSC165609
NSC170951
NSC8971
Nasol
Neodurasina
Neodurasina (TN)
Oprea1_287330
PDSP1_000168
PDSP1_001106
PDSP1_001343
PDSP1_001345
PDSP1_001346
PDSP1_001347
PDSP2_000167
PDSP2_001090
PDSP2_001327
PDSP2_001329
PDSP2_001330
PDSP2_001331
PSEUDOEPHEDRINE
Pedia Care
Pseudo
Pseudo 60's
Pseudo-12
Pseudoefedrina
Pseudoephedrine (D)
Pseudoephedrinum
Psi-ephedrin
Psi-ephedrine
Robidrine
SMR000059174
SPBio_000214
SPBio_001365
SPBio_001377
ST023802
STK367993
STOCK1N-42675
Sanedrine
Spectrum2_000137
Spectrum2_001303
Spectrum2_001309
Spectrum3_000414
Spectrum3_000563
Spectrum3_001771
Spectrum4_000497
Spectrum4_001162
Spectrum5_000650
Spectrum5_000879
Spectrum5_001106
Spectrum_000878
Spectrum_001020
Sudafed
Sudafed Decongestant
UNII-03VRY66076
UNII-7CUC9DDI9F
UNII-GN83C131XS
Vencipon
WLN: QYR & Y1 & M1
WLN: QYR&Y1&M1
Zephrol
d-Ephedrine
d-Isoephedrine
d-Pseudoephedrine
d-psi-Ephedrine
l-Ephedrine
l-Pseudoephedrine
racephedrine
trans-Ephedrine
32
Bimatoprostapproved, investigationalPhase 3, Phase 1, Phase 2129155206-00-15311027
Synonyms:
(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1e,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
155206-00-1
15M
267244-98-4
5-Heptenamide,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ehtyl-,(5Z)
AC1NSJUW
AGN 192024
AGN-192024
Bimataprost [USAN:INN:BAN]
Bimatoprost
Bimatoprost (JAN/USAN/INN)
Bimatoprost [USAN:INN:BAN]
Bimatoprostum
 
CHEBI:39562
CHEBI:51230
CHEMBL1200963
CID5311027
D02724
DB00905
DB06863
I06-1275
I06-1277
LS-181817
Latisse
Lumigan
Lumigan (TN)
NCGC00181745-01
UNII-QXS94885MZ
ZINC04474405
bimatoprostum
33Vasoconstrictor AgentsPhase 31303
34Nasal DecongestantsPhase 3414
35TetrahydrozolinePhase 3542
36AnestheticsPhase 17385
37
Imidacloprid139105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado

Interventional clinical trials:

(show all 23)
idNameStatusNCT IDPhase
1Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in CanadaCompletedNCT01415401Phase 4
2Comparison of Brimonidine Purite, Dorzolamide, and Brinzolamide as Adjunctive Therapy to Prostaglandin AnalogsCompletedNCT00675207Phase 4
3Dose, Effects and Characteristics of PilocarpineCompletedNCT00803803Phase 4
4Inhaled Corticosteroids: Effect on Intraocular Pressure in Patients With Controlled GlaucomaCompletedNCT02338362Phase 4
5Comparison of Combigan BID Versus Simbrinza TIDRecruitingNCT02167035Phase 4
6Efficacy of Changing to DuoTrav® (Travoprost 0.004%/Timolol 0.5% BAK-Free Fixed Combination) From Prior TherapyTerminatedNCT01514721Phase 4
7Equivalence Study of Dorzolamide 2% Eye Drops SolutionCompletedNCT00878917Phase 3
8Tafluprost-Timolol Fixed Dose Combination Non-Inferiority Study Against Concomitant AdministrationsCompletedNCT01306461Phase 3
9Safety and Efficacy of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular HypertensionRecruitingNCT02250651Phase 3
10A Study of Different Formulations of the L-PPDS in Subjects With OH or OAGCompletedNCT00967811Phase 2
11Study of Medical Treatment of Low-Pressure (Normal Tension) GlaucomaCompletedNCT00317577Phase 2
12Safety and Efficacy of a New Ophthalmic Formulation of Bimatoprost in Patients With Open Angle Glaucoma and Ocular HypertensionActive, not recruitingNCT01157364Phase 1, Phase 2
13Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma.RecruitingNCT02330978Phase 1
14Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital GlaucomaNot yet recruitingNCT01460017Phase 1
15Safety Study of Latanoprost Slow Release InsertTerminatedNCT01180062Phase 1
16Spectral Domain Optical Coherence Tomography Analysis for GlaucomaCompletedNCT01612416
17Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma?CompletedNCT00312403
18Multicentric Observational Study on Quality of Life in GlaucomaCompletedNCT01742104
19Comparing the Effect of the Water Drinking Test on Intraocular PressureCompletedNCT02001155
20How Accurately Does the Diopsys Visual Evoked Potential (VEP) Vision Testing System Detect Glaucoma?CompletedNCT02622178
21Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human EyeRecruitingNCT01348672
22Analysis of Clinical Profiles of Chinese Patients With Normal Tension GlaucomaRecruitingNCT00321386
23Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human EyeRecruitingNCT01348633

Search NIH Clinical Center for Glaucoma 1, Open Angle, E

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Glaucoma 1, Open Angle, E cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Glaucoma 1, Open Angle, E:
Renexus
Embryonic/Adult Cultured Cells Related to Glaucoma 1, Open Angle, E:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Glaucoma 1, Open Angle, E

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Genetic tests related to Glaucoma 1, Open Angle, E:

id Genetic test Affiliating Genes
1 Glaucoma 1, Open Angle, E22 OPTN
2 Primary Open Angle Glaucoma (adult Onset)22 WDR36

Anatomical Context for Glaucoma 1, Open Angle, E

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MalaCards organs/tissues related to Glaucoma 1, Open Angle, E:

33
Eye, Testes

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Glaucoma 1, Open Angle, E:
id TissueAnatomical CompartmentCell Relevance
1 EyeGanglion Cell LayerMature Ganglion Cells Affected by disease

Animal Models for Glaucoma 1, Open Angle, E or affiliated genes

About this section

MGI Mouse Phenotypes related to Glaucoma 1, Open Angle, E:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.1ABCA4, ATOH7, CYP1B1, MYOC, SIX1, SIX6

Publications for Glaucoma 1, Open Angle, E

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Variations for Glaucoma 1, Open Angle, E

About this section

UniProtKB/Swiss-Prot genetic disease variations for Glaucoma 1, Open Angle, E:

67 (show all 17)
id Symbol AA change Variation ID SNP ID
1CYP1B1p.Gly61GluVAR_001244rs28936700
2CYP1B1p.Trp57CysVAR_008350
3CYP1B1p.Glu387LysVAR_008352rs55989760
4CYP1B1p.Tyr81AsnVAR_028736rs9282671
5CYP1B1p.Ser28TrpVAR_054227
6CYP1B1p.Arg145TrpVAR_054235
7CYP1B1p.Glu229LysVAR_054243rs57865060
8CYP1B1p.Gly232ArgVAR_054244
9CYP1B1p.Leu345PheVAR_054251rs66583685
10CYP1B1p.Val409PheVAR_054258
11CYP1B1p.Asn423TyrVAR_054260
12CYP1B1p.Arg523ThrVAR_054267
13CYP1B1p.Asp530GlyVAR_054268
14OPTNp.His26AspVAR_021537
15OPTNp.Glu50LysVAR_021538rs28939688
16OPTNp.Glu103AspVAR_021540
17OPTNp.His486ArgVAR_021546

Clinvar genetic disease variations for Glaucoma 1, Open Angle, E:

5
id Gene Variation Type Significance SNP ID Assembly Location
1LTBP2NM_000428.2(LTBP2): c.1484G> A (p.Arg495Gln)single nucleotide variantLikely pathogenicrs137854858GRCh37Chr 14, 75017969: 75017969
2LTBP2NM_000428.2(LTBP2): c.3571G> A (p.Glu1191Lys)single nucleotide variantLikely pathogenicrs137854862GRCh37Chr 14, 74975388: 74975388
3LTBP2NM_000428.2(LTBP2): c.4250A> G (p.Gln1417Arg)single nucleotide variantLikely pathogenicrs137854863GRCh37Chr 14, 74971805: 74971805
4LTBP2NM_000428.2(LTBP2): c.4912G> A (p.Val1638Met)single nucleotide variantLikely pathogenicrs137854860GRCh37Chr 14, 74969614: 74969614
5OPTNNM_001008211.1(OPTN): c.293T> A (p.Met98Lys)single nucleotide variantPathogenic, risk factorrs11258194GRCh37Chr 10, 13152400: 13152400

Expression for genes affiliated with Glaucoma 1, Open Angle, E

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Search GEO for disease gene expression data for Glaucoma 1, Open Angle, E.

Pathways for genes affiliated with Glaucoma 1, Open Angle, E

About this section

Pathways related to Glaucoma 1, Open Angle, E according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.0ELN, LOXL1, TGFB2

GO Terms for genes affiliated with Glaucoma 1, Open Angle, E

About this section

Biological processes related to Glaucoma 1, Open Angle, E according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen fibril organizationGO:003019910.6CYP1B1, TGFB2
2generation of neuronsGO:004869910.4SIX1, TGFB2
3eye developmentGO:000165410.1SIX6, TGFB2
4extracellular matrix organizationGO:003019810.0ELN, LOXL1, TGFB2

Sources for Glaucoma 1, Open Angle, E

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet