GLC1G
MCID: GLC060
MIFTS: 21

Glaucoma 1, Open Angle, G (GLC1G) malady

Categories: Genetic diseases, Eye diseases

Aliases & Classifications for Glaucoma 1, Open Angle, G

Aliases & Descriptions for Glaucoma 1, Open Angle, G:

Name: Glaucoma 1, Open Angle, G 54 66 29 13 69
Primary Open Angle Glaucoma 1g 66
Glc1g 66

Classifications:



External Ids:

OMIM 54 609887
MedGen 40 C1835933
MeSH 42 D005902

Summaries for Glaucoma 1, Open Angle, G

UniProtKB/Swiss-Prot : 66 Glaucoma 1, open angle, G: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.

MalaCards based summary : Glaucoma 1, Open Angle, G, also known as primary open angle glaucoma 1g, is related to glaucoma 1, open angle, e, and has symptoms including primary open angle glaucoma An important gene associated with Glaucoma 1, Open Angle, G is WDR36 (WD Repeat Domain 36). The drugs Latanoprost and Timolol have been mentioned in the context of this disorder. Affiliated tissues include eye.

Description from OMIM: 609887

Related Diseases for Glaucoma 1, Open Angle, G

Diseases in the Glaucoma 1, Open Angle, G family:

Glaucoma 1, Open Angle, F Glaucoma 1, Open Angle, E

Diseases related to Glaucoma 1, Open Angle, G via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 glaucoma 1, open angle, e 10.9

Symptoms & Phenotypes for Glaucoma 1, Open Angle, G

Clinical features from OMIM:

609887

Human phenotypes related to Glaucoma 1, Open Angle, G:

32
id Description HPO Frequency HPO Source Accession
1 primary open angle glaucoma 32 HP:0012108

Drugs & Therapeutics for Glaucoma 1, Open Angle, G

Drugs for Glaucoma 1, Open Angle, G (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
2
Timolol Approved Phase 4,Phase 2,Phase 3,Early Phase 1 26839-75-8 33624 5478
3
Travoprost Approved Phase 4,Phase 2 157283-68-6 5282226
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5
Maleic acid Experimental Phase 4,Phase 2 110-16-7 444266
6 Antihypertensive Agents Phase 4,Phase 2,Phase 3
7 Ophthalmic Solutions Phase 4,Phase 2
8 Tetrahydrozoline Phase 4
9 Adrenergic Agents Phase 4,Phase 2,Phase 3
10 Adrenergic Antagonists Phase 4,Phase 2,Phase 3
11 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3
12 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3
13 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
14 Vitamins Phase 4
15 Anti-Bacterial Agents Phase 4
16 Antibiotics, Antitubercular Phase 4
17 Mitomycins Phase 4,Early Phase 1
18 Pharmaceutical Solutions Phase 4,Phase 2
19 Adrenergic Agonists Phase 4,Phase 2
20 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2
21 Adrenergic alpha-Agonists Phase 4,Phase 2
22 Brimonidine Tartrate Phase 4,Phase 2 70359-46-5
23 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Phase 3
24
Dorzolamide Approved Phase 2, Phase 3 120279-96-1 3154 5284549
25
Bimatoprost Approved, Investigational Phase 3 155206-00-1 5311027
26
Menthol Approved Early Phase 1 2216-51-5 16666

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Safety, Efficacy Assessment of Geltim LP® 1 mg/g in Ocular Hypertensive or Glaucomatous Patients. Completed NCT01155219 Phase 4
2 Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG) Completed NCT00913029 Phase 4
3 Value of an Intervention to Enhance Adherence in Glaucoma Patients Completed NCT00756184 Phase 4
4 Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma Completed NCT00444080 Phase 4
5 24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol Completed NCT00981786 Phase 4
6 A Comparison of the Effect of Dorzolamide and Timolol on Optic Disk Blood Flow in Patients With Open Angle Glaucoma Completed NCT00991822 Phase 2, Phase 3
7 Safety and Efficacy of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension Recruiting NCT02250651 Phase 3
8 Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma Completed NCT00317577 Phase 2
9 Safety and Efficacy of ENV515 Travoprost Extended Release (XR) in Patients With Bilateral Ocular Hypertension or Primary Open Angle Glaucoma Recruiting NCT02371746 Phase 2
10 Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma Unknown status NCT00321386
11 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
12 Spectral Domain Optical Coherence Tomography Analysis for Glaucoma Completed NCT01612416
13 Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma? Completed NCT00312403
14 Adherence With Fixed Versus Unfixed Glaucoma Therapy Completed NCT01281020
15 A Trial of China Laser and Surgery Study Glaucoma in Rural China Active, not recruiting NCT02955849 Early Phase 1
16 Progressive Open Angle Glaucoma (OAG) and Ocular Blood Flow Withdrawn NCT00912470

Search NIH Clinical Center for Glaucoma 1, Open Angle, G

Genetic Tests for Glaucoma 1, Open Angle, G

Genetic tests related to Glaucoma 1, Open Angle, G:

id Genetic test Affiliating Genes
1 Glaucoma 1, Open Angle, G 29

Anatomical Context for Glaucoma 1, Open Angle, G

MalaCards organs/tissues related to Glaucoma 1, Open Angle, G:

39
Eye

Publications for Glaucoma 1, Open Angle, G

Variations for Glaucoma 1, Open Angle, G

UniProtKB/Swiss-Prot genetic disease variations for Glaucoma 1, Open Angle, G:

66
id Symbol AA change Variation ID SNP ID
1 WDR36 p.Asn355Ser VAR_025966 rs118204022
2 WDR36 p.Arg529Gln VAR_025968 rs116529882

ClinVar genetic disease variations for Glaucoma 1, Open Angle, G:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 WDR36 NM_139281.2(WDR36): c.1064A> G (p.Asn355Ser) single nucleotide variant Pathogenic rs118204022 GRCh37 Chromosome 5, 110440041: 110440041

Expression for Glaucoma 1, Open Angle, G

Search GEO for disease gene expression data for Glaucoma 1, Open Angle, G.

Pathways for Glaucoma 1, Open Angle, G

GO Terms for Glaucoma 1, Open Angle, G

Sources for Glaucoma 1, Open Angle, G

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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