MCID: GLC076
MIFTS: 10

Glaucoma 1, Open Angle, H malady

Aliases & Classifications for Glaucoma 1, Open Angle, H

Aliases & Descriptions for Glaucoma 1, Open Angle, H:

Name: Glaucoma 1, Open Angle, H 54 29 13

External Ids:

OMIM 54 611276

Summaries for Glaucoma 1, Open Angle, H

MalaCards based summary : Glaucoma 1, Open Angle, H An important gene associated with Glaucoma 1, Open Angle, H is GLC1H (Glaucoma 1, Open Angle, H (Adult-Onset)). The drugs Latanoprost and Timolol have been mentioned in the context of this disorder.

Description from OMIM: 611276

Related Diseases for Glaucoma 1, Open Angle, H

Symptoms & Phenotypes for Glaucoma 1, Open Angle, H

Clinical features from OMIM:

611276

Drugs & Therapeutics for Glaucoma 1, Open Angle, H

Drugs for Glaucoma 1, Open Angle, H (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Latanoprost Approved, Investigational Phase 4,Phase 1 130209-82-4 5282380 5311221
2
Timolol Approved Phase 4 26839-75-8 33624 5478
3
Ephedrine Approved Phase 4 299-42-3 9294
4
Pseudoephedrine Approved Phase 4 90-82-4 7028
5
Travoprost Approved Phase 4 157283-68-6 5282226
6 Antihypertensive Agents Phase 4,Phase 3,Phase 1
7 Cloprostenol Phase 4
8 Adrenergic Agents Phase 4,Phase 3
9 Nasal Decongestants Phase 4
10 Adrenergic Antagonists Phase 4
11 Neurotransmitter Agents Phase 4,Phase 3
12 Adrenergic beta-Antagonists Phase 4
13 Contraceptive Agents Phase 4
14 Tetrahydrozoline Phase 4
15 Ophthalmic Solutions Phase 4,Phase 3,Phase 1
16 Peripheral Nervous System Agents Phase 4
17 Vasoconstrictor Agents Phase 4
18 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1
19 Anti-Arrhythmia Agents Phase 4
20 Respiratory System Agents Phase 4
21 Luteolytic Agents Phase 4
22 Autonomic Agents Phase 4
23
Brinzolamide Approved Phase 3 138890-62-7 68844
24 Carbonic Anhydrase Inhibitors Phase 3
25 Brimonidine Tartrate Phase 3 70359-46-5
26 Adrenergic Agonists Phase 3
27 Adrenergic alpha-2 Receptor Agonists Phase 3
28 Adrenergic alpha-Agonists Phase 3

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP) Completed NCT01162603 Phase 4
2 A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma Completed NCT00887029 Phase 4
3 Efficacy and Safety Study of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% and Brimonidine 0.2% Completed NCT01297517 Phase 3
4 Three Month Efficacy/Safety Study With a 3-Month Safety Extension of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% or Brimonidine 0.2% Completed NCT01297920 Phase 3
5 A Three Part Study of MGV354 in Ocular Hypertension or Glaucoma Completed NCT02743780 Phase 1, Phase 2
6 A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO5093151 in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT). Completed NCT02622334 Phase 1
7 Efficacy Comparison of Xalatan and Azopt on POAG and OH Unknown status NCT01084902
8 24-hour IOP Fluctuation Profile Recorded With SENSIMED Triggerfish in Primary Open-angle Glaucoma (POAG) Patients After Cataract Surgery Unknown status NCT01495299
9 Dry Eye and Irritation Comparison of Latanoprost With the Preservative Versus Travoprost Without Preservative Completed NCT00803387
10 PIO Laser Sclerectomy IOP SLT Sclerectomy Completed NCT01798732
11 Effects of Latanoprost on Choroidal Blood Flow Regulation in Human Subjects Completed NCT00712400

Search NIH Clinical Center for Glaucoma 1, Open Angle, H

Genetic Tests for Glaucoma 1, Open Angle, H

Genetic tests related to Glaucoma 1, Open Angle, H:

id Genetic test Affiliating Genes
1 Glaucoma 1, Open Angle, H 29

Anatomical Context for Glaucoma 1, Open Angle, H

Publications for Glaucoma 1, Open Angle, H

Variations for Glaucoma 1, Open Angle, H

Expression for Glaucoma 1, Open Angle, H

Search GEO for disease gene expression data for Glaucoma 1, Open Angle, H.

Pathways for Glaucoma 1, Open Angle, H

GO Terms for Glaucoma 1, Open Angle, H

Sources for Glaucoma 1, Open Angle, H

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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