MCID: GLC051
MIFTS: 15

Glaucoma 1, Open Angle, M

Aliases & Classifications for Glaucoma 1, Open Angle, M

MalaCards integrated aliases for Glaucoma 1, Open Angle, M:

Name: Glaucoma 1, Open Angle, M 54 29 13

Characteristics:

OMIM:

54
Miscellaneous:
age of onset/diagnosis 12-35 years

Inheritance:
autosomal dominant


HPO:

32
glaucoma 1, open angle, m:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 54 610535

Summaries for Glaucoma 1, Open Angle, M

MalaCards based summary : Glaucoma 1, Open Angle, M and has symptoms including open angle glaucoma and constriction of peripheral visual field. An important gene associated with Glaucoma 1, Open Angle, M is GLC1M (Glaucoma 1, Open Angle, M (Juvenile-Onset)). The drugs Brinzolamide and Timolol have been mentioned in the context of this disorder. Affiliated tissues include eye.

Description from OMIM: 610535

Related Diseases for Glaucoma 1, Open Angle, M

Diseases in the Glaucoma 1, Open Angle, H family:

Glaucoma 1, Open Angle, M Glaucoma 1, Open Angle, N

Symptoms & Phenotypes for Glaucoma 1, Open Angle, M

Symptoms via clinical synopsis from OMIM:

54

Head And Neck- Eyes:
visual field loss
thin or notched neuroretinal rim
disc hemorrhage
vertical cup-to-disc ratio greater than or equal to 0.7
bilateral intraocular pressures greater than or equal to 22 mmhg
more

Clinical features from OMIM:

610535

Human phenotypes related to Glaucoma 1, Open Angle, M:

32
id Description HPO Frequency HPO Source Accession
1 open angle glaucoma 32 HP:0012108
2 constriction of peripheral visual field 32 HP:0001133

Drugs & Therapeutics for Glaucoma 1, Open Angle, M

Drugs for Glaucoma 1, Open Angle, M (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Brinzolamide Approved Phase 4,Phase 3 138890-62-7 68844
2
Timolol Approved Phase 4,Phase 3,Phase 2 26839-75-8 33624 5478
3
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
4
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
5
Latanoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130209-82-4 5282380 5311221
6
Sorbitol Approved Phase 4 50-70-4 5780
7
Maleic acid Experimental Phase 4 110-16-7 444266
8 Adrenergic Agents Phase 4,Phase 3,Phase 2
9 Adrenergic Agonists Phase 4,Phase 3,Phase 2
10 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2
11 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
12 Adrenergic Antagonists Phase 4,Phase 3,Phase 2
13 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2
14 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
15 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Brimonidine Tartrate Phase 4,Phase 3,Phase 2 70359-46-5
17 Carbonic Anhydrase Inhibitors Phase 4,Phase 3,Phase 2
18 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
19 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
20 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
21 Cloprostenol Phase 4
22 Contraceptive Agents Phase 4
23 Luteolytic Agents Phase 4
24 Cathartics Phase 4
25 Gastrointestinal Agents Phase 4
26 Laxatives Phase 4
27 Anticoagulants Phase 4
28 Blood Substitutes Phase 4
29 Dextrans Phase 4
30 Lubricant Eye Drops Phase 4
31 Plasma Substitutes Phase 4
32 Tetrahydrozoline Phase 4,Phase 3
33 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
34 Alkylating Agents Phase 4
35 Anti-Bacterial Agents Phase 4
36 Antibiotics, Antitubercular Phase 4
37 Mitomycins Phase 4
38 Nucleic Acid Synthesis Inhibitors Phase 4
39
Dorzolamide Approved Phase 3,Phase 2 120279-96-1 3154 5284549
40
Epigallocatechin gallate Investigational Phase 1, Phase 2 989-51-5 65064
41 Antioxidants Phase 1, Phase 2
42 Neuroprotective Agents Phase 1, Phase 2
43 Protective Agents Phase 1, Phase 2
44
Epigallocatechin Experimental, Nutraceutical Phase 1, Phase 2 970-74-1 72277
45
Apraclonidine Approved 66711-21-5 2216
46
Cortisone acetate Approved 1950-04-4, 50-04-4 5745
47
Diclofenac Approved, Vet_approved 15307-86-5 3033
48
Methylprednisolone Approved, Vet_approved 83-43-2 6741
49
Prednisolone Approved, Vet_approved 50-24-8 5755
50
Prednisone Approved, Vet_approved 53-03-2 5865

Interventional clinical trials:

(show all 33)

id Name Status NCT ID Phase Drugs
1 Evaluation of Intraocular Pressure Using Simbrinza™ in Patients With Open-Angle Glaucoma or Ocular Hypertension Completed NCT01978600 Phase 4 Brinzolamide 1%/Brimonidine 0.2% ophthalmic suspension;Timolol Maleate 0.5%
2 Effect of SIMBRINZA® Suspension as an Added Therapy to a Prostaglandin Analogue Completed NCT01937312 Phase 4 Brinzolamide 1%/brimonidine 0.2% ophthalmic suspension;Vehicle;Prostaglandin analogue
3 Effect of SIMBRINZA® Suspension as an Added Therapy to TRAVATAN Z® Completed NCT01937299 Phase 4 Brinzolamide 1%/brimonidine 0.2% ophthalmic suspension;Vehicle;Travoprost 0.004% ophthalmic solution
4 A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma Completed NCT00887029 Phase 4 DuoTrav (travoprost-timolol ophthalmic drops);Xalacom (latanoprost-timolol ophthalmic drops)
5 Efficacy of Travoprost/Timolol for Uncontrolled Intraocular Pressure Completed NCT02003391 Phase 4 Beta-blocker monotherapy;Travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution
6 Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG) Completed NCT00698945 Phase 4 Istalol and Optive;Alphagan
7 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4 travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
8 A Comparison of Xalatan (Latanoprost) to Apo-latanoprost and Co-latanoprost in the Treatment of Glaucoma Recruiting NCT02792803 Phase 4 Xalatan;Apo-Latanoprost;Co-Latanoprost
9 Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on COMBIGAN® (Brimonidine 0.2%/Timolol 0.5% Fixed Combination) Therapy in Brazil Terminated NCT01514734 Phase 4 Brinzolamide/timolol maleate fixed combination
10 A Clinical Study Comparing the Inflammatory Response of the Ex-Press Mini Shunt to Trabeculectomy Terminated NCT00597181 Phase 4
11 Travacom Post Marketing Surveillance Study Withdrawn NCT01510132 Phase 4 Travoprost/timolol fixed combination (Travacom)
12 PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM) Recruiting NCT03193333 Phase 3 PRO-122;Timolol eye drops;Dorzolamide-Timolol Ophthalmic;Brimonidine Ophthalmic Solution;Krytantek
13 Non-inferiority of PRO-067 Ophthalmic Solution vs GAAP Ofteno® in Glaucoma or Ocular Hypertension Recruiting NCT02801617 Phase 3 PRO-067;GAAP Ofteno®
14 Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension Recruiting NCT02507687 Phase 3 Bimatoprost SR
15 Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-angle Glaucoma or Ocular Hypertension Recruiting NCT02247804 Phase 3 Bimatoprost sustained-release;Timolol;Timolol Vehicle (placebo)
16 A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension Recruiting NCT02636946 Phase 3 Bimatoprost SR;Sham Bimatoprost SR
17 Safety and Efficacy of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension Recruiting NCT02250651 Phase 3 Bimatoprost sustained-release;Timolol;Timolol Vehicle (placebo)
18 1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT Terminated NCT00767481 Phase 3 Travoprost/Brinzolamide;Cosopt
19 Effect of Epigallocatechin-Gallate on Inner Retinal Function in Ocular Hypertension and Early Glaucoma Unknown status NCT00476138 Phase 1, Phase 2 Epigallocatechin-gallate
20 Study to Evaluate the Safety, Tolerability, and Efficacy of LX7101 in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension Completed NCT01528111 Phase 1, Phase 2 LX7101 (0.125%);LX7101 (0.25%);LX7101 Vehicle
21 A Phase 2 Single-Masked, Randomized Study of Latanoprost PPDS in Ocular Hypertension or Open-Angle Glaucoma Completed NCT02014142 Phase 2 Latanoprost Punctal Plug Delivery System (L-PPDS)
22 Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma Completed NCT00317577 Phase 2 brimonidine, timolol
23 Clinical Study of A Fixed Combination of Timolol-Brimonidine-Dorzolamide Completed NCT01062971 Phase 2 dorzolamide-timolol-brimonidine
24 Study Assessing Safety and Efficacy of PG324 Ophthalmic Solution in Patients With Elevated Intraocular Pressure Completed NCT02057575 Phase 2 PG324 Ophthalmic Solution 0.01%;PG324 Ophthalmic Solution 0.02%;Netarsudil (AR-13324) Ophthalmic Solution;Latanoprost Ophthalmic Solution
25 Safety Study of Latanoprost Slow Release Insert Terminated NCT01180062 Phase 1 Latanoprost;Arm 2;Latanoprost SR insert
26 Near to Infrared (NIR) Light Neuroprotection in Glaucomatous Optic Neuropathy Unknown status NCT00844389 Early Phase 1
27 The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma Unknown status NCT01020721
28 Spectral Domain Optical Coherence Tomography Analysis for Glaucoma Completed NCT01612416
29 Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma? Completed NCT00312403
30 Impact Post-operative Treatment on Intraocular Pressure Post-SLT on Patients With Primary Open-angle Glaucoma Completed NCT01058278
31 Effect of Yellow-Tinted Intraocular Lens on Standard Automated Perimetry (SAP) and Short-wavelength Automated Perimetry (SWAP) in Patients With and Without Glaucoma Completed NCT01305616
32 Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan Completed NCT00121147 Travatan;Azopt;Alphagan P
33 Prevalence of Dyschromatopsia in Glaucoma Patients Withdrawn NCT01994564

Search NIH Clinical Center for Glaucoma 1, Open Angle, M

Genetic Tests for Glaucoma 1, Open Angle, M

Genetic tests related to Glaucoma 1, Open Angle, M:

id Genetic test Affiliating Genes
1 Glaucoma 1, Open Angle, M 29

Anatomical Context for Glaucoma 1, Open Angle, M

MalaCards organs/tissues related to Glaucoma 1, Open Angle, M:

39
Eye

Publications for Glaucoma 1, Open Angle, M

Variations for Glaucoma 1, Open Angle, M

Expression for Glaucoma 1, Open Angle, M

Search GEO for disease gene expression data for Glaucoma 1, Open Angle, M.

Pathways for Glaucoma 1, Open Angle, M

GO Terms for Glaucoma 1, Open Angle, M

Sources for Glaucoma 1, Open Angle, M

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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