MCID: GLC080
MIFTS: 13

Glaucoma 1, Open Angle, N

Aliases & Classifications for Glaucoma 1, Open Angle, N

MalaCards integrated aliases for Glaucoma 1, Open Angle, N:

Name: Glaucoma 1, Open Angle, N 54 29

External Ids:

OMIM 54 611274

Summaries for Glaucoma 1, Open Angle, N

MalaCards based summary : Glaucoma 1, Open Angle, N An important gene associated with Glaucoma 1, Open Angle, N is GLC1N (Glaucoma 1, Open Angle, N (Juvenile-Onset)). The drugs Timolol and Latanoprost have been mentioned in the context of this disorder. Affiliated tissues include eye.

Description from OMIM: 611274

Related Diseases for Glaucoma 1, Open Angle, N

Diseases in the Glaucoma 1, Open Angle, H family:

Glaucoma 1, Open Angle, M Glaucoma 1, Open Angle, N

Symptoms & Phenotypes for Glaucoma 1, Open Angle, N

Clinical features from OMIM:

611274

Drugs & Therapeutics for Glaucoma 1, Open Angle, N

Drugs for Glaucoma 1, Open Angle, N (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 4 26839-75-8 33624 5478
2
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
3 Adrenergic Agents Phase 4
4 Adrenergic Antagonists Phase 4
5 Adrenergic beta-Antagonists Phase 4
6 Anti-Arrhythmia Agents Phase 4
7 Antihypertensive Agents Phase 4,Phase 3
8 Neurotransmitter Agents Phase 4
9
Bimatoprost Approved, Investigational Phase 3 155206-00-1 5311027
10
Betamethasone Approved, Vet_approved Phase 2 378-44-9 9782
11
Ephedrine Approved Phase 2 299-42-3 9294
12
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
13
Pseudoephedrine Approved Phase 2 90-82-4 7028
14 Anti-Asthmatic Agents Phase 2
15 Antifungal Agents Phase 2
16 Anti-Infective Agents Phase 2
17 Anti-Inflammatory Agents Phase 2,Phase 1
18 Antirheumatic Agents Phase 2
19 Autonomic Agents Phase 2
20 Betamethasone benzoate Phase 2
21 Betamethasone sodium phosphate Phase 2
22 Betamethasone Valerate Phase 2 2152-44-5
23 Betamethasone-17,21-dipropionate Phase 2
24 Calcineurin Inhibitors Phase 2
25 Cyclosporins Phase 2
26 Dermatologic Agents Phase 2
27 glucocorticoids Phase 2
28 Hormone Antagonists Phase 2
29 Hormones Phase 2
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
31 Immunosuppressive Agents Phase 2
32 Nasal Decongestants Phase 2
33 Ophthalmic Solutions Phase 2,Phase 1
34 Peripheral Nervous System Agents Phase 2
35 Pharmaceutical Solutions Phase 2,Phase 1
36 Respiratory System Agents Phase 2
37 Tetrahydrozoline Phase 2,Phase 1
38 Vasoconstrictor Agents Phase 2
39
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
40 Grape Approved, Nutraceutical Phase 1
41
Curcumin Investigational Phase 1 458-37-7 969516
42 Natriuretic Peptide, C-Type Phase 1
43 Antineoplastic Agents, Phytogenic Phase 1
44 Antioxidants Phase 1
45 Cytidine Diphosphate Choline Phase 1
46 Grape Seed Extract Phase 1
47 N-monoacetylcystine Phase 1
48 Protective Agents Phase 1
49 Thioctic Acid Phase 1
50 Ubiquinone Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Non Interventional Study With Primary Open Angle Glaucoma and/or Ocular Hypertension Patients Treated With Xalacom® After Failure of Previous Antiglaucoma Therapy. Completed NCT00801437 Phase 4 Xalacom
2 Non Interventional Study in Patients With Open Angle Glaucoma and/or Ocular Hypertension Treated With XALATAN® Completed NCT00486252 Phase 4
3 A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension Recruiting NCT02636946 Phase 3 Bimatoprost SR;Sham Bimatoprost SR
4 Comparison of Effect of Postoperative Cyclosporine A 2% Ophthalmic Emulsion and Betamethasone Eye Drop on Surgical Success of Trabeculectomy Procedure Completed NCT02114073 Phase 2 Cyclosporine;Betamethasone
5 Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma Recruiting NCT03131167 Phase 1 SHP639 (n=60);Placebo Comparator (n=24)
6 Safety and Efficacy of Anti-Oxidants and Anti-inflammatory Agents in Glaucoma and Diabetic Retinopathy Active, not recruiting NCT02984813 Phase 1 GlaucoHealth;GlaucoSelect;Placebo
7 Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348672
8 Diagnostic Innovations in Glaucoma Study Unknown status NCT00221897
9 Progressive Open Angle Glaucoma (OAG) and Ocular Blood Flow Withdrawn NCT00912470

Search NIH Clinical Center for Glaucoma 1, Open Angle, N

Genetic Tests for Glaucoma 1, Open Angle, N

Genetic tests related to Glaucoma 1, Open Angle, N:

id Genetic test Affiliating Genes
1 Glaucoma 1, Open Angle, N 29

Anatomical Context for Glaucoma 1, Open Angle, N

MalaCards organs/tissues related to Glaucoma 1, Open Angle, N:

39
Eye

Publications for Glaucoma 1, Open Angle, N

Variations for Glaucoma 1, Open Angle, N

Expression for Glaucoma 1, Open Angle, N

Search GEO for disease gene expression data for Glaucoma 1, Open Angle, N.

Pathways for Glaucoma 1, Open Angle, N

GO Terms for Glaucoma 1, Open Angle, N

Sources for Glaucoma 1, Open Angle, N

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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