Glaucoma, Congenital malady

Wikipedia: Congenital glaucoma is evident either at birth or within the first few years of life. This condition is...⁴⁴ more...

MalaCards: Glaucoma, Congenital, also known as glaucoma, is related to open-angle glaucoma and primary open angle glaucoma. An important gene associated with Glaucoma, Congenital is FOXC1 (forkhead box C1), and among its related pathways is Transcriptional Regulatory Network in Embryonic Stem Cell. The drugs physostigmine sulfate and carbachol and the compounds quinone and theophylline have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and vision/eye.

glaucoma, congenital 30 32 glaucoma 43

Diseases related to glaucoma, congenital by text searches and GeneDecks gene sharing:

(show top 50)    (show all 162)

id	Related Disease	Score	Top Affiliating Genes
1	open-angle glaucoma	36.0	MYOC, CYP1B1, OPTN
2	primary open angle glaucoma	35.6	CYP1B1, MYOC, OPTN
3	primary congenital glaucoma	33.2	MYOC, FOXC1, CYP1B1
4	primary angle-closure glaucoma	31.3	MYOC, CYP1B1, OPTN
5	primary open angle glaucoma juvenile onset 1	30.2	MYOC, OPTN
6	early-onset glaucoma	29.8	CYP1B1, MYOC
7	juvenile glaucoma	29.7	MYOC, FOXC1, CYP1B1
8	ocular hypertension	29.4	MYOC, OPTN
9	iris hypoplasia and glaucoma	29.2	PAX6, FOXC1
10	cataract-glaucoma	29.1	FOXC1, PAX6
11	primary open angle glaucoma (adult onset)	29.1	MYOC, CYP1B1
12	interval angle-closure glaucoma	29.0	MYOC, CYP1B1, OPTN
13	cataract	28.7	MYOC, PAX6, FOXC1
14	retinitis	27.9	OPTN, MYOC, PAX6, CYP1B1, TYR
15	axenfeld-rieger syndrome	27.8	FOXC1, CYP1B1
16	glaucoma, early-onset, digenic	27.7	CYP1B1, MYOC
17	buphthalmos	27.7	MYOC, CYP1B1
18	aniridia	27.6	CYP1B1, FOXC1, PAX6
19	iris hypoplasia	26.0	PAX6, FOXC1
20	microcoria	25.0	OPTN, MYOC, CYP1B1
21	peters anomaly	24.9	FOXC1, CYP1B1, PAX6
22	glaucoma	24.4	OPTN, TYR, CYP1B1, MYOC, PAX6, FOXC1
23	blindness	24.0	MYOC, PAX6, FOXC1, CYP1B1, TYR, OPTN
24	optic nerve disease	12.8	OPTN, MYOC
25	intestinal atresia	12.7	FOXC1, PAX6
26	chorioretinitis	12.6	FOXC1, PAX6
27	x-linked infantile nystagmus	12.6	TYR, PAX6
28	waardenburg's syndrome	12.5	PAX6, TYR
29	corneal edema	12.4	CYP1B1, MYOC
30	corneal dystrophy	12.4	MYOC, PAX6
31	cerebellar hypoplasia	12.3	PAX6, FOXC1
32	developmental disabilities	12.3	PAX6, FOXC1, TYR
33	retinal disease	12.2	PAX6, OPTN, MYOC
34	nystagmus	12.0	PAX6, TYR
35	stickler syndrome	11.9	MYOC, PAX6, FOXC1, OPTN
36	pancreatic ductal carcinoma	11.8	PAX6, FOXC1, CYP1B1
37	lung cancer susceptibility	11.7	FOXC1, CYP1B1, TYR
38	choroiditis	11.5	TYR, CYP1B1, PAX6
39	angle-closure glaucoma	8.6
40	exfoliation syndrome	8.5
41	neovascular glaucoma	8.4
42	low tension glaucoma	7.9
43	chronic closed-angle glaucoma	7.3
44	hypertension	7.3
45	steroid-induced glaucoma	7.3
46	glaucoma 3 primary infantile b	7.1
47	pigment dispersion syndrome	7.1
48	steroid-induced glaucoma - borderline	6.9
49	traumatic glaucoma	6.9
50	acute closed-angle glaucoma	6.9

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetazolamide, acetazolamide sodium, carbachol, clonidine, clonidine hcl pwdr [va product], clonidine hydrochloride, dichlorphenamide, isoflurophate, mitomycin, physostigmine, physostigmine salicylate, physostigmine sulfate

MGI Mouse Phenotypes related to glaucoma, congenital:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	8.9	PAX6, FOXC1, TYR
2	vision/eye phenotype	MP:0005391	7.3	MYOC, PAX6, FOXC1, CYP1B1, TYR

Genes related to glaucoma, congenital according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	FOXC1	forkhead box C1	11.0
2	OPTN	optineurin	11.0
3	MYOC	myocilin, trabecular meshwork inducible glucocorticoid response	11.0
4	PAX6	paired box 6	11.0
5	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	11.0
6	TYR	tyrosinase (oculocutaneous albinism IA)	11.0

Pathways related to glaucoma, congenital according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Transcriptional Regulatory Network in Embryonic Stem Cell36	9.4	PAX6, FOXC1

Compounds related to glaucoma, congenital according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	quinone32 18	10.0	CYP1B1, TYR
2	theophylline32 9 18 9	11.8	CYP1B1, TYR
3	cycloheximide32	8.6	TYR, CYP1B1, MYOC
4	dexamethasone32 42 34 9 9	12.2	TYR, OPTN, MYOC, CYP1B1

Biological processes related to glaucoma, congenital according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	eye development	GO:001654	9.4	PAX6, FOXC1
2	visual perception	GO:007601	8.2	PAX6, CYP1B1, TYR