Glioblastoma malady

Wikipedia: Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in...⁴⁴ more...

MalaCards: Glioblastoma, also known as glioblastoma multiforme, is related to carcinoma and prostatitis. An important gene associated with Glioblastoma is ERBB2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)), and among its related pathways are JAK-STAT Pathway and JNK Pathway. The drug carmustine and the compounds adenylate and phospholipid have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cerebellum, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

OMIM: 137800

Aliases & Descriptions:

glioblastoma 6 7 30 8 33 32 43 glioblastoma multiforme 6 7 30 32 43 giant cell glioblastoma (histologic variant) 30 glioblastoma nos (morphologic abnormality) 6 glioblastoma (morphologic abnormality) 6

gliosarcoma (histologic variant) 30 primary glioblastoma multiforme 6 spongioblastoma multiforme 6 primary glioblastoma 43 gbm (glioblastoma) 6

Disease types for glioblastoma family:

glioblastoma 3

Diseases related to glioblastoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 765)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	166.8	ZNF217, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
2	prostatitis	145.1	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PI15
3	leukemia	137.1	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
4	neuronitis	134.0	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
5	adenocarcinoma	132.6	ZNF217, PIK3CA, PIK3R1, PIK3CG, PIN1, LRP1
6	melanoma	130.1	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
7	pancreatitis	129.4	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PI15
8	hepatocellular carcinoma	124.1	PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1, KLF6
9	colorectal cancer	120.4	ZNF217, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R4
10	neuroblastoma	115.4	PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1, LRP1
11	thyroiditis	114.5	PIK3CA, PIK3R1, PI15, PIK3CG, PIN1, LRP1
12	colon cancer	113.0	PIK3CA, PIK3R3, PIK3R1, PIK3CG, KLF6, NCAM1
13	hypoxia	112.0	ZNF217, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
14	astrocytoma	107.7	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, NCAM1
15	cerebritis	98.2	PIK3R1, PIK3CG, LRP1, KLF6, NCAM1, CNR1
16	myeloid leukemia	91.9	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
17	colon carcinoma	83.4	PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1, PDCD4
18	malignant glioma	80.3	PIK3CA, PIK3CG, KIT, KITLG, VWF, VTN
19	retinoblastoma	79.7	PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1
20	asthma	75.1	PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1, LRP1
21	meningioma	72.6	PIK3CG, NCAM1, PCNA, RB1, NBN, SETD2
22	gastric cancer	72.3	PIK3CA, PIK3R1, PIK3CG, PIN1, KLF6, PDCD4
23	medulloblastoma	69.0	PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCAM1, KIT
24	cervicitis	66.8	ZNF217, PIK3CA, PIK3CG, PIN1, PDCD4, CNR1
25	breast carcinoma	66.6	ZNF217, PIK3CA, PIK3R1, PIK3CG, PI3, LRP1
26	thyroid cancer	65.8	PIK3CA, PIK3R1, PIK3CG, KIT, PCNA, BUB1
27	esophagitis	65.5	PIK3CA, PIK3CG, PIN1, KLF6, NCAM1, PDCD4
28	pancreatic carcinoma	65.0	PIK3CA, NCAM1, KITLG, VTN, PCNA, RB1
29	sarcoma	62.1	PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1
30	arthritis	61.8	PIK3CD, PIK3CG, PIN1, LRP1, CNR1, CNR2
31	gonococcal synovitis	61.4	PIK3CA, PIK3R1, PIK3CG, PI3, LRP1, NCAM1
32	squamous cell carcinoma	58.1	PIK3CA, PIN1, PI3, VTN, PCNA, RB1
33	ovarian carcinoma	58.0	PIK3CA, PIK3CG, PI3, PDCD4, KIT, VTN
34	lung carcinoma	57.5	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, PCNA
35	rheumatoid arthritis	57.4	PIK3CD, PIK3CG, PIN1, LRP1, CNR1, CNR2
36	herpes simplex	57.2	PIK3CA, PIK3CG, PCNA, SERPINE1, VIM, VEGFA
37	retinitis	57.0	PIK3CA, PIK3CG, LRP1, KLF6, CNR1, CNR2
38	adenoma	56.9	PIK3CA, LRIG3, NCAM1, PDCD4, CNR1, KIT
39	fibrosis	56.8	PIK3CA, PIK3CG, PIN1, PI3, LRP1, KLF6
40	myeloma	56.3	PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, NCAM1
41	alzheimer's disease	55.5	PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1, WDR11
42	liver cancer	54.5	PIK3CG, PIN1, RB1, SETD2, SERPINB5, VEGFA
43	cervical cancer	53.6	ZNF217, PIK3CA, PIK3CG, PIN1, VTN, PCNA
44	osteosarcoma	51.7	PIK3CA, PIK3CG, CNR1, KIT, VWF, VTN
45	ischemia	51.6	PIK3CA, PIK3CG, NCAM1, CNR1, CNR2, KITLG
46	wilms tumor	51.2	NCAM1, VWF, PCNA, BUB1B, BTRC, SETD2
47	prostate carcinoma	51.0	PIK3R1, PIK3CG, LRP1, KLF6, CNR1, VTN
48	oligodendroglioma	50.5	PIK3CA, KLF6, NCAM1, PCNA, RB1, VIM
49	anaplastic astrocytoma	50.5	PCNA, RB1, BSG, VEGFA, BLZF1, LGALS1
50	atherosclerosis	50.3	PIK3CG, PI3, LRP1, CNR1, CNR2, VWF

Clinical features from OMIM: 137800

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine

MalaCards organs/tissues related to glioblastoma:

²²

MGI Mouse Phenotypes related to glioblastoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	INF	PDCD4, KIT, BRAF, BRCA1, , VAV3
2	endocrine/exocrine gland phenotype	MP:0005379	INF	PDCD4, BUB1, RBL1, NBN, SELL, SERPINE2
3	nervous system phenotype	MP:0003631	INF	LRP1, CNR1, KIT, KITLG, VWF, PCNT
4	skeleton phenotype	MP:0005390	INF	PIK3CD, PIK3CG, LRP1, CNR1, KIT, KITLG
5	digestive/alimentary phenotype	MP:0005381	INF	KIT, KITLG, VWF, RB1, RBL1, BRAF
6	growth/size phenotype	MP:0005378	INF	PIK3CA, PIK3R1, PIK3CG, PIN1, LRP1, KLF6
7	mortality/aging	MP:0010768	INF	PIK3CA, LRP1, KLF6, NCAM1, PDCD4, CNR1
8	immune system phenotype	MP:0005387	INF	PIK3CD, LRP1, PDCD4, CNR2, KIT, VWF
9	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, LRIG3, LRP1, LRRC4, KLF9, NCAM1
10	vision/eye phenotype	MP:0005391	32.1	PIK3CA, PIN1, NCAM1, KIT, KITLG, BUB1B
11	no phenotypic analysis	MP:0003012	22.5	PIK3CD, PIK3R1, CNR1, PCNA, BUB1, RB1
12	adipose tissue phenotype	MP:0005375	21.8	PIK3CA, PIK3R1, LRP1, CNR1, BUB1B, BUB3
13	pigmentation phenotype	MP:0001186	17.4	KIT, KITLG, RB1, BRAF, BRCA1, MYC
14	respiratory system phenotype	MP:0005388	17.0	SESN2, SELL, BRCA1, MYCN, RAB3D, RAD50
15	other phenotype	MP:0005395	16.6	CNR1, BUB1, RARA, RARB, KDR, SCNN1G
16	hematopoietic system phenotype	MP:0005397	INF	KLF6, KIT, PCNA, BUB1, BUB1B, BTRC
17	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
18	reproductive system phenotype	MP:0005389	INF	PIK3CA, KLF6, PDCD4, KIF11, BUB1, BUB1B
19	craniofacial phenotype	MP:0005382	INF	LRIG3, KIT, KITLG, RBL1, NBN, LPAR1
20	tumorigenesis	MP:0002006	INF	PIK3CA, PIK3R2, PIK3R1, PDCD4, KIT, KITLG
21	embryogenesis phenotype	MP:0005380	INF	PIK3CA, KLF6, KIT, KIF11, PCNT, BUB1B
22	integument phenotype	MP:0010771	INF	PIK3CG, PIN1, KLF6, CNR1, CNR2, KIT
23	cellular phenotype	MP:0005384	INF	PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1, KLF6
24	cardiovascular system phenotype	MP:0005385	INF	PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1
25	limbs/digits/tail phenotype	MP:0005371	INF	KIT, KITLG, PCNT, RB1, RBL1, BRCA1
26	liver/biliary system phenotype	MP:0005370	INF	KLF6, KIT, BUB1, RBL1, , VEGFA
27	hearing/vestibular/ear phenotype	MP:0005377	INF	LRIG3, LRRC4, KIT, KITLG, RB1, MYC
28	normal phenotype	MP:0002873	INF	PIK3R1, LRP1, VTN, BUB1, RBL1, SEMA3B
29	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, KIT

Articles related to glioblastoma:

(show top 50)    (show all 1734)

id	Title	Authors	Year	Affiliating Genes
1	Regulation of Cdk7 activity through a phosphatidylino sitol (3)-kinase/PKC-I^-mediated signaling cascade in glioblastoma. (22021906)	Desai S.R.... Acevedo-Duncan M.E.	2012	CDK7, PRKCI
2	Caveolin-1 regulates glioblastoma aggressiveness through the control of alpha(5)beta(1) integrin expression and modulates glioblastoma responsiveness to SJ749, an alpha(5)beta(1) integrin antagonist. (18992284)	Martin S.... Dontenwill M.	2009	ITGB1, CAV1, ITGA5
3	Expression of CXCL12 on pseudopalisading cells and proliferating microvessels in glioblastomas: an accelerated growth factor in glioblastomas. (19212671)	Komatani H.... Shigemori M.	2009	CXCL12
4	LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. (19127268)	Fuh B.... Lin J.	2009	CASP3, PARP1, STAT3
5	Knockdown of ASIC1 and epithelial sodium channel subu nits inhibits glioblastoma whole cell current and cell migration. (19561078)	Kapoor N.... Benos D.J.	2009	SCNN1A, SCNN1G, ASIC1
6	Expression of Transketolase-like 1 and Activation of Akt in Grade IV Glioblastomas Compared With Grades II and III Astrocytic Gliomas. (18550470)	Volker H.U.... Monoranu C.M.	2008	AKT1, TKTL1
7	Polymorphism in the microglial cell-mobilizing CX3CR1 gene is associated with survival in patients with glioblastoma. (19001328)	Rodero M.... Combadiere C.	2008	CCL2, CX3CR1
8	Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors. (17401009)	Faury D.... Jabado N.	2007	YBX1
9	Roles of Kunitz domains in the anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells. (17949349)	Miyata S.... Kataoka H.	2007	PRSS8, HPN, SPINT1
10	Combination of all-trans retinoic acid and interferon-gamma suppressed PI3K/Akt survival pathway in glioblastoma T98G cells whereas NF-kappaB survival signaling in glioblastoma U87MG cells for induction of apoptosis. (17616812)	Zhang R.... Ray S.K.	2007	CASP3, PTEN, PIK3CG
11	Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol. (16709245)	Combs S.E.... Schulz-Ertner D.	2006	EGFR
12	A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. (17090523)	Liu F.... Johnson M.D.	2006	EPHA2
13	Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. (17075581)	Zagzag D.... Newcomb E.W.	2006	CXCR4, VEGFA, HIF1A
14	Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. (16540650)	Wu H.... Hait W.N.	2006	EEF2K
15	Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. (16627485)	Kishi Y.... Arai H.	2006	ENPP2, LPAR1
16	Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane. (16765523)	Karmakar S.... Ray S.K.	2006	BCL2, BAX, CASP9
17	Effect of antisense epidermal growth factor receptor cDNA transfection on telomerase activity of glioblastomas cells (15968328)	Tian X.X.... Zheng J.	2005	EGFR
18	The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. (16103100)	Graff J.R.... Thornton D.	2005	PRKCB
19	Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. (16061850)	Diesel B.... Meese E.	2005	CYP24A1, CYP27B1
20	Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. (16106218)	Van Brocklyn J.R.... Prior T.W.	2005	SPHK1, S1PR3, S1PR2
21	Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. (15800333)	Lefranc F.... Kiss R.	2005	PIK3CA, MTOR
22	hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines. (16175187)	Masi A.... Arcangeli A.	2005	VEGFA, SPON1
23	Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice. (15671563)	Liu T.F.... Frankel A.E.	2005	EGF
24	ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. (15509542)	Kodama T.... Okada Y.	2004	EGF, ADAM12, HBEGF
25	Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms. (15326475)	Chakravarti A.... Loeffler J.	2004	BIRC5
26	Receptor protein tyrosine phosphatase zeta as a therapeutic target for glioblastoma therapy. (15161428)	Muller S.... Westphal M.	2004	PTN, PTPRZ1
27	Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398. (15105053)	Obara S.... Kuratsu J.	2004	PTEN, ILK
28	Aromatase, the enzyme responsible for estrogen biosynthesis, is expressed by human and rat glioblastomas. (15364411)	Yague J.G.... Garcia-Segura L.M.	2004	CYP19A1
29	Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. (14583498)	Shinojima N.... Ushio Y.	2003	EGFR
30	Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length. (11953893)	Tian X.X.... Ng H.K.	2002	EGFR
31	Immunohistochemical analysis of reactive astrocytes around glioblastoma: an immunohistochemical study of postmortem glioblastoma cases. (11932042)	Nagashima G.... Fujimoto T.	2002	MMP2, GFAP
32	Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas. (12168053)	Gonzalez-Gomez P.... Rey J.A.	2002	RB1, RBL1
33	Glioblastoma multiforme in an Asian population: evidence for a distinct genetic pathway. (12635658)	Das A.... Smith D.R.	2002	PDGFRA, MDM2, EGFR
34	Distribution of epidermal growth factor receptor protein correlates with gain in chromosome 7 revealed by comparative genomic hybridization after microdissection in glioblastoma multiforme. (11432670)	Romeike B.F.... Urbschat S.M.	2001	EGFR
35	Analysis of interleukin-6 gene expression in primary human gliomas, glioblastoma xenografts, and glioblastoma cell lines. (11517969)	Sasaki A.... Nakazato Y.	2001	IL6, IL1B, IL8
36	Reduced expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin (HAI-2/PB) in human glioblastomas: implication for anti-invasive role of HAI-2/PB in glioblastoma cells. (11433397)	Hamasuna R.... Koono M.	2001	SPINT2, HGFAC
37	Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor. (11565870)	Nagane M.... Huang H.J.	2001	EGFR
38	Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion. (11156378)	Kondraganti S.... Rao J.S.	2000	MMP9
39	Differential effects of the insulin-like growth factor I receptor on radiosensitivity and spontaneous necrosis formation of human glioblastoma cells grown in multicellular spheroids. (10388524)	Watanabe H.... Sasaki T.	1999	IGF1R
40	Graphic analysis of microscopic tumor cell infiltration, proliferative potential, and vascular endothelial growth factor expression in an autopsy brain with glioblastoma. (10086494)	Nagashima G.... Fujimoto T.	1999	VEGFA
41	PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas. (9690672)	Tohma Y.... Ohgaki H.	1998	PTEN
42	CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. (8548755)	Ueki K.... Louis D.N.	1996	CDK4, RB1
43	Expression of N-cadherin and alpha-catenin in astrocytomas and glioblastomas. (7669572)	Shinoura N.... Hirohashi S.	1995	CDH2, CTNNA1
44	Expression of p53 in glioblastoma multiforme cells: relationship to survival, proliferation and glycosylation. (9444787)	Ehrmann J.... Komenda S.	1995	TP53
45	Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification. (8036013)	Ekstrand A.J.... James C.D.	1994	EGFR
46	Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo. (8120140)	Tada M.... de Tribolet N.	1994	IL1RN
47	Retroviral-mediated transduction of p53 gene increases TGF-beta expression in a human glioblastoma cell line. (8119773)	Fujiwara T.... Grimm E.A.	1994	TP53
48	Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells. (1409674)	Taylor J.P.... Amini S.	1992	COL1A1, FN1, COL1A2
49	Antigen variation in a human glioblastoma: from the primary tumor to the second recurrence, permanent cell line and xenotransplantation tumors. (2064311)	Bilzer T.... Keiditsch E.	1991	S100B, VIM
50	Induction of the myelin proteolipid protein (PLP) gene in C6 glioblastoma cells: functional analysis of the PLP promotor. (1719156)	Nave K.A.... Lemke G.	1991	PLP1

Genes related to glioblastoma according to GeneCards:

(show top 50)    (show all 1027)

id	Symbol	Description	Score	GeneCards Section Context
1	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.1	Transcripts, Publications, Aliases & Descriptions, Orthologs
2	LGI1	leucine-rich, glioma inactivated 1	11.0	Functions, Summaries
3	BAI1	brain-specific angiogenesis inhibitor 1	11.0	Expressions, Publications, Functions, Summaries
4	TRIM8	tripartite motif containing 8	11.0	Aliases & Descriptions
5	NDRG2	NDRG family member 2	11.0	Expressions, Publications, Summaries
6	PI15	peptidase inhibitor 15	11.0	Publications, Summaries
7	THEM4	thioesterase superfamily member 4	11.0	Expressions, Publications, Summaries
8	WDR11	WD repeat domain 11	11.0	Publications, Summaries
9	TGFB2	transforming growth factor, beta 2	11.0	Publications, Aliases & Descriptions
10	LOC100420430	glioblastoma amplified sequence pseudogene	11.0	Aliases & Descriptions
11	GBAS	glioblastoma amplified sequence	11.0	Transcripts, Aliases & Descriptions, Functions, Orthologs
12	GOPC	golgi-associated PDZ and coiled-coil motif containing	11.0	Publications, Aliases & Descriptions
13	RAB3D	RAB3D, member RAS oncogene family	11.0	Publications, Aliases & Descriptions
14	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	11.0	Publications, Aliases & Descriptions
15	EBF3	early B-cell factor 3	11.0	Summaries
16	TRRAP	transformation/transcription domain-associated protein	11.0	Summaries
17	GFAP	glial fibrillary acidic protein	11.0	Publications
18	PTEN	phosphatase and tensin homolog	11.0	Publications, Functions, Pathways & Interactions
19	EGFR	epidermal growth factor receptor	11.0	Publications, Functions, Pathways & Interactions
20	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications, Pathways & Interactions
21	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0	Publications
22	TP53	tumor protein p53	11.0	Publications, Pathways & Interactions
23	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
24	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
25	MGMT	O-6-methylguanine-DNA methyltransferase	10.9	Publications, Pathways & Interactions
26	NES	nestin	10.9	Publications
27	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	10.9	Publications
28	IL13RA2	interleukin 13 receptor, alpha 2	10.9	Publications
29	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	10.9	Publications
30	SPHK1	sphingosine kinase 1	10.9	Publications
31	CDK4	cyclin-dependent kinase 4	10.9	Publications, Functions, Pathways & Interactions
32	DMBT1	deleted in malignant brain tumors 1	10.9	Publications, Functions
33	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	10.9	Publications
34	KLF6	Kruppel-like factor 6	10.9	Publications
35	ADM	adrenomedullin	10.9	Publications
36	ANGPT2	angiopoietin 2	10.9	Publications
37	CA9	carbonic anhydrase IX	10.9	Publications
38	EPHA2	EPH receptor A2	10.9	Publications
39	IL13RA1	interleukin 13 receptor, alpha 1	10.9	Publications
40	LGALS1	lectin, galactoside-binding, soluble, 1	10.9	Publications
41	PDGFB	platelet-derived growth factor beta polypeptide	10.9	Publications, Pathways & Interactions
42	PLAUR	plasminogen activator, urokinase receptor	10.9	Publications
43	PMEL	premelanosome protein	10.9	Publications
44	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	10.9	Publications
45	CDKN2A	cyclin-dependent kinase inhibitor 2A	10.9	Publications, Pathways & Interactions
46	CDKN3	cyclin-dependent kinase inhibitor 3	10.9	Publications
47	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	10.9	Publications
48	DCT	dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)	10.9	Publications
49	GJA1	gap junction protein, alpha 1, 43kDa	10.9	Publications
50	IL4R	interleukin 4 receptor	10.9	Publications

Pathways related to glioblastoma according to GeneDecks:

(show top 50)    (show all 471)

id	Pathway	Score	Top Affiliating Genes
1	JAK-STAT Pathway36	INF	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
2	JNK Pathway36	INF	PIK3R4, PIK3R1, KIT, KITLG, VEGFB, BMP4
3	p70S6K Signaling36	18.5	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
4	Rac1 Pathway36	17.8	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KITLG, VEGFB
5	Endocytosis20	16.6	KIT, KDR, LDLR, CDC42, ITCH, FLT1
6	MAPK signaling pathway20	16.3	BRAF, MYC, RAF1, RAC1, PAK1, MRAS
7	cAMP Pathway36	16.3	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
8	Melanoma20	16.0	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
9	Glioma Invasiveness36	15.1	PIK3R3, PIK3R2, PIK3R4, KITLG, VTN, VEGFB
10	p53 signaling pathway20	15.1	SESN2, SERPINB5, SERPINE1, BID, CHEK1, CHEK2
11	Chronic myeloid leukemia20	14.8	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
12	Development_HGF signaling pathway41	14.5	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, RAF1
13	Chemokine signaling pathway20	14.5	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
14	Rap1 Pathway36	14.4	KITLG, BRAF, VEGFB, VEGFC, BMP4, BMP6
15	mTOR signaling pathway20	14.0	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
16	Signaling Involved in Cardiac Hypertrophy36	13.9	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BRAF, RAF1
17	Development Neurotrophin family signaling10	13.9	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, BRAF
18	Development_Neurotrophin family signaling41	13.8	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, BRAF
19	Progesterone-mediated oocyte maturation20	13.6	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG
20	Development PDGF signaling via STATs and NF-kB10	13.6	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, MYC
21	Development HGF signaling pathway10	13.4	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, RAF1
22	Transcription_Receptor-mediated HIF regulation41	13.2	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, VEGFA
23	Cell adhesion_Plasmin signaling41	13.1	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, VEGFA
24	Immune response_IL-10 signaling pathway41	13.1	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, BCL2L1
25	Immune response IL-23 signaling pathway10	13.1	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, JAK2
26	G1-S Phase Transition36	13.0	RB1, ATM, CDK6, CDKN1A, CDKN2C, CDK2
27	Transcription_CREB pathway41	12.6	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, RAF1
28	Development_CNTF receptor signaling41	12.5	PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1, LIFR
29	Development_EPO-induced Jak-STAT pathway41	12.5	MYC, BCL2, BCL2L1, XIAP, JAK2, GRB2
30	Immune response_IL-3 activation and signaling pathway41	12.2	RAF1, JUN, JUND, JAK2, FOS, FOSL1
31	Development_Flt3 signaling41	12.1	PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAC1, PAK1
32	Immune response IL-9 signaling pathway10	11.7	PIK3CD, PIK3R3, PIK3R2, RAF1, IRS1, GRB2
33	Transcription Androgen Receptor nuclear signaling10	11.2	RAF1, FZD1, FZD10, FZD2, FZD3, FZD4
34	Breast Cancer Regulation by Stathmin136	11.2	PIK3R3, PIK3R2, PIK3R4, PIK3R1, VEGFB, BMP4
35	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	11.1	PIK3CD, PIK3R2, MAPK9
36	ErbB Family Pathway36	11.0	PIK3R3, PIK3R2, PIK3R4, PIK3R1, BRAF, RAF1
37	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.9	JAK2, GRB2, MAPK3, MAP2K1, TRH, PTPN1
38	MNAR-PELP1 and Estrogen Receptor Interaction36	10.7	RB1, MRAS, JUN, FOS, MAPK3, MAPK1
39	Development_Angiotensin signaling via PYK241	10.1	PIK3R3, PIK3R2, PIK3R1, RAF1, RAC1, PAK1
40	LPS Stimulated MAPK Signaling36	9.9	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RAF1, RAC1
41	Basal cell carcinoma20	9.8	BMP4, LEF1, AXIN1, FZD1, FZD10, FZD2
42	Development_EDNRB signaling41	9.8	PIK3CG, BRAF, RAF1, ITPR1, ITPR2, ITPR3
43	ErbB2-ErbB3 Heterodimers36	9.5	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RAF1, BAD
44	Melanogenesis20	9.2	KIT, KITLG, RAF1, LEF1, FZD1, FZD10
45	Glioblastoma Multiforme36	7.5	PIK3R3, PIK3R2, PIK3R4, PIK3R1, RB1, BRAF
46	Pancreatic Adenocarcinoma36	INF	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG
47	TCR Signaling36	INF	PIK3R3, PIK3R2, PIK3R4, PIK3R1, VAV3, RAF1
48	MIF Mediated Glucocorticoid Regulation36	INF	BMP4, BMP6, LIF, BCL2, BAX,
49	MIF Regulation of Innate Immune Cells36	INF	BMP4, BMP6, LIF, BCL2, BAX, JUN
50	MAPK Signaling36	INF	PIK3R3, PIK3R2, PIK3R4, PIK3R1, KIT, KITLG

Compounds related to glioblastoma according to GeneDecks:

(show top 50)    (show all 419)

id	Compound	Score	Top Affiliating Genes
1	adenylate32	INF	PIK3CA, PIK3CG, KLF6, CNR1, CNR2, KITLG
2	phospholipid32	INF	PIK3R1, VWF, LPAR1, VCL, BLZF1, KCNMA1
3	serine32	INF	PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1, PI3
4	gaba32 42	INF	NCAM1, CNR1, VIM, VIP, KCNMA1, CKB
5	rapamycin32 42	INF	PIK3CG, PIN1, KIT, KITLG, RB1, NBN
6	nmda32 42	INF	PIK3CA, LRP1, NCAM1, CNR1, VIM, LNX1
7	arginine32	INF	PIK3CA, CNR1, CNR2, VWF, VTN, RBL1
8	carbon32	INF	CNR1, CNR2, VWF, VTN, PCNA, LDLR
9	iron32 18	INF	KITLG, SETD2, VIM, , LPO, MYCN
10	5fluorouracil32	26.9	PIK3CA, PIK3CG, KIT, KITLG, PCNA, RB1
11	retinoid32	21.5	SELL, VIM, MYC, MYCN, BMP4, BMP6
12	fibrinogen32	20.2	KLF6, VTN, SERPINF2, SERPINE1, NAMPT, VCAM1
13	chloramphenicol32 9 9	22.1	PI3, KLF9, SETD2, SERPINE1, VIM, MYC
14	quercetin32 42 9 18 9	23.3	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R4, PIK3R1
15	bortezomib32 9 9	20.8	SETD2, BRCA1, VEGFA, MYC, BID, BIRC5
16	agarose32	18.3	KIT, KITLG, VWF, BRCA1, MYC, MYCN
17	geldanamycin32 9 9	20.2	PIK3R1, PIK3CG, SETD2, BRAF, VEGFA, VCL
18	ag 147832	18.1	PIK3CA, PIK3CG, SERPINE1, RAF1, BAK1, JUN
19	fatty acid32	18.0	PI3, LRP1, NAMPT, BRAF, BRCA1, LPO
20	troglitazone32 42 9 9	20.9	PIK3CG, RB1, SERPINE1, VCAM1, BMP6, RARA
21	formaldehyde32 18	18.8	KIT, VWF, PCNA, RB1, SELL, VIM
22	guanine32 9 18 9	20.4	CNR1, VWF, SETD2, VIP, BRCA1, RAD51
23	rottlerin32 42	17.8	PIK3R1, PIK3CG, VCAM1, RAC1, PARP1, XIAP
24	irinotecan32 34 9 9	19.7	KIT, BRAF, VEGFA, PARP1, BCL2L1, CHEK1
25	mitomycin c32	16.3	VWF, PCNA, RB1, NBN, BRCA1, BRCA2
26	4-hydroxynonenal32 18	16.6	MYC, RALBP1, PARP1, CHKA, BAX, MPO
27	diphenyleneiodonium32	15.3	SETD2, VEGFA, VCAM1, RAC1, MPO, JUN
28	noxa32	15.1	BID, BIRC5, BCL2, BCL2L1, BCL2L11, BBC3
29	ifn-alpha32	14.6	LIF, PARK2, CDK2, CDKN2A, IRF1, IL10
30	mifepristone32 42 9 9	17.4	PI3, LIF, BIRC5, BCL2L1, MUC1, BAX
31	sulindac32 9 9	16.3	PCNA, BIRC5, BCL2, BCL2L1, BAX, SAT1
32	losartan32 34 9 9	17.3	VWF, PCNA, SERPINE1, VCAM1, BMP6, ATM
33	eb 108932	13.9	PCNA, PARP1, BCL2, BAX, CDK6, CDKN1A
34	roscovitine32	13.9	PIK3CG, PCNA, VIM, BIRC5, PARP1, BCL2L1
35	triptolide32	13.6	VEGFA, PARP1, BCL2, BAX, JUN, CD86
36	valproic acid32 34 9 18 9	17.4	NCAM1, KITLG, VCL, MYCN, CFLAR, CDK4
37	o6-methylguanine32	13.3	PCNA, BRAF, BRCA2, RAD51, RARB, RASSF1
38	ns 39832 42	14.3	PIK3CG, PCNA, PARP1, CDKN1B, MMP1, FGF2
39	taxane32	13.2	VEGFA, BIRC5, KDR, BCL2, MTOR, MTHFR
40	acetaminophen32 34 9 18 9	16.9	PCNA, MYC, BCL2L1, SDHB, MMP3, ANXA5
41	pioglitazone32 9 9	14.9	BSG, NAMPT, VEGFA, VCAM1, RARA, JUN
42	bapta32	12.8	SETD2, RAF1, S100A6, CDC42, FPR1, FOS
43	sp 60012532 42	13.7	PIK3CG, VCAM1, BID, CDKN1A, MMP1, MMP13
44	u012632 42	13.6	PIK3CG, JUN, MMP1, IL6, IL8, MAPK8
45	estrogen32	INF	PIK3R1, KLF6, VWF, PCNA, SETD2, SERPINB5
46	actinomycin d32	INF	PIK3CA, PIK3CG, KIT, KITLG, RB1, SERPINE2
47	ly29400232	INF	PIK3CA, PIK3R1, PIK3CG, PI3, VTN,
48	glutamate32	INF	PIK3CA, PIK3R1, NCAM1, CNR1, CNR2, VTN
49	acth32	INF	VIP, LIFR, PAM, LGALS3, MUC1, MIF
50	butyrate32	INF	KITLG, PCNA, RB1, SETD2, VIM, MYC

Cellular components related to glioblastoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	INF	LRP1, CNR1, CNR2, SELL, LPAR1, RAMP2
2	plasma membrane	GO:005886	INF	PIK3CD, PIK3R1, PIK3CG, LRRC4, NCAM1, CNR1
3	extracellular space	GO:005615	28.4	KIT, KITLG, VTN, SERPINB5, SERPINF2, SERPINE1
4	external side of plasma membrane	GO:009897	15.7	NCAM1, KIT, VWF, SELL, VCAM1, KDR
5	perinuclear region of cytoplasm	GO:048471	15.3	BUB1B, RAD51, PARK2, BCL10, YWHAB, MTDH
6	platelet alpha granule lumen	GO:031093	13.3	VWF, SERPINF2, SERPINE1, VEGFA, VEGFB, VEGFC
7	membrane	GO:016020	INF	PIK3CG, SEMA3B, , VEGFA, VEGFB, VEGFC
8	cytosol	GO:005829	INF	PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R4, PIK3R1
9	extracellular region	GO:005576	INF	PI15, NCAM1, KITLG, VWF, VTN, SERPINE2
10	cell surface	GO:009986	INF	NCAM1, VEGFA, LPAR1, VCAM1, RAMP2, RARA
11	nucleoplasm	GO:005654	INF	ZNF217, PIN1, PCNA, RB1, RBL1, NBN
12	extracellular matrix	GO:031012	INF	VWF, VTN, SERPINE2, SERPINE1, VCAN, RARRES2
13	cytoplasm	GO:005737	INF	PIK3CG, PIN1, WDR11, LRP1, KLF6, PDCD4
14	neuronal cell body	GO:043025	INF	SERPINE2, MTOR, LAMP1, S100B, CDK5, CDC42
15	nucleus	GO:005634	INF	ZNF320, ZNF167, PIN1, LRP1, KLF6, KLF9

Biological processes related to glioblastoma according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	angiogenesis	GO:001525	INF	PIK3CA, PIK3CG, SETD2, SERPINE1, VEGFA, VEGFC
2	positive regulation of cell proliferation	GO:008284	23.7	KIT, NBN, VIP, NAMPT, VEGFA, VEGFC
3	blood coagulation	GO:007596	21.7	PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG, KIF11
4	cell proliferation	GO:008283	20.2	KITLG, PCNA, BUB1, BUB1B, NBN, NANOG
5	negative regulation of apoptotic process	GO:043066	20.0	PIK3CG, SERPINE1, BRAF, VEGFA, MYC, BMP4
6	response to drug	GO:042493	18.0	NBN, VEGFC, VAV3, MYC, PARK7, PAM
7	inflammatory response	GO:006954	17.7	PIK3CD, PIK3CG, CNR2, KIT, BMP6, RAC1
8	innate immune response	GO:045087	17.2	PIK3CD, PIK3R4, PIK3CG, PIN1, BCL10, BCL2
9	response to hypoxia	GO:001666	17.0	VEGFA, VCAM1, BNIP3, RAF1, USF1, CLDN3
10	protein phosphorylation	GO:006468	16.9	PIK3CD, PIK3R4, BRAF, BMX, RARA, RAF1
11	cytokine-mediated signaling pathway	GO:019221	16.8	PIN1, KLF6, NCAM1, KIT, VCAM1, LIFR
12	platelet activation	GO:030168	16.6	PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3CG, VWF
13	axon guidance	GO:007411	16.2	NCAM1, SEMA3B, RAF1, RAC1, PAK1, PAX6
14	positive regulation of apoptotic process	GO:043065	16.2	CNR1, LPAR1, BMP4, RARB, BID, BCL2L11
15	positive regulation of cell migration	GO:030335	15.9	VEGFA, KDR, LEF1, FURIN, JAK2, ITGAV
16	heart development	GO:007507	15.7	PCNA, VCAM1, VCAN, RAMP2, RAF1, PAM
17	negative regulation of transcription, DNA-dependent	GO:045892	15.2	ZNF217, PDCD4, BTRC, RB1, BRCA1, BMP4
18	positive regulation of ERK1 and ERK2 cascade	GO:070374	15.0	SERPINF2, BRAF, VEGFB, BMP4, KDR, CHI3L1
19	positive regulation of angiogenesis	GO:045766	14.8	SERPINE1, VEGFA, RAMP2, KDR, CHI3L1, MTDH
20	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	14.8	MYC, BCL2L11, BBC3, BAD, BAX, JAK2
21	insulin receptor signaling pathway	GO:008286	14.7	PIK3CA, PIK3R3, PIK3R2, PIK3R4, PIK3R1, NAMPT
22	transforming growth factor beta receptor signaling pathway	GO:007179	14.6	RBL1, SERPINE1, MYC, PARP1, UBC, BAMBI
23	positive regulation of gene expression	GO:010628	14.6	KIT, BRAF, VEGFA, RAMP2, PAX6, LEF1
24	response to organic cyclic compound	GO:014070	14.6	BMP4, LEF1, BAK1, MSH2, JUN, CDKN1A
25	platelet degranulation	GO:002576	14.5	VWF, SERPINF2, SERPINE1, VEGFA, VEGFB, VEGFC
26	positive regulation of protein phosphorylation	GO:001934	14.5	PIN1, VEGFA, BMP4, MTOR, AXIN1, FZD1
27	aging	GO:007568	14.5	CNR1, VCAM1, BAK1, FURIN, JUN, GRB2
28	response to ethanol	GO:045471	14.5	CNR1, BCL2, BAK1, S100A8, S100A9, FYN
29	peptidyl-tyrosine phosphorylation	GO:018108	14.4	KIT, KDR, FYN, JAK2, FLT1, FLT4
30	response to wounding	GO:009611	14.3	VWF, RAC1, PAX6, ITGB4, FN1, MET
31	leukocyte migration	GO:050900	14.3	PIK3CA, PIK3R2, PIK3R1, SELL, BSG, YES1
32	negative regulation of neuron apoptotic process	GO:043524	14.2	NAIP, BRAF, VEGFB, LIG4, PARK7, PARK2
33	positive regulation of endothelial cell proliferation	GO:001938	14.2	VEGFA, VEGFB, BMP4, BMP6, KDR, MTOR
34	positive regulation of MAPK cascade	GO:043410	14.1	KIT, LPAR1, LIF, KDR, CDH2, ITGB1
35	positive regulation of fibroblast proliferation	GO:048146	13.8	MYC, BMI1, LIG4, S100A6, JUN, CDK6
36	regulation of cell proliferation	GO:042127	13.8	PIN1, KIT, SERPINE1, BRCA1, BID, BIRC7
37	cellular response to mechanical stimulus	GO:071260	13.5	BNIP3, BCL10, CHEK1, BAD, BAK1, ITGB1
38	positive regulation of cell division	GO:051781	13.5	VEGFA, VEGFB, VEGFC, YBX1, FIGF, FGF1
39	elevation of cytosolic calcium ion concentration	GO:007204	13.4	LPAR1, S1PR3, FZD2, JAK2, CD24, ITPR1
40	positive regulation of protein kinase B signaling cascade	GO:051897	13.3	PIK3CG, VEGFB, CHI3L1, MTDH, MTOR, AXL
41	positive regulation of smooth muscle cell proliferation	GO:048661	13.2	SERPINF2, BMP4, JUN, FLT1, IL13, IL6
42	response to glucocorticoid stimulus	GO:051384	12.7	SERPINE1, PAM, INSR, IL10, IL1B, IL1RN
43	Ras protein signal transduction	GO:007265	12.7	RB1, RAF1, RASSF1, YWHAB, MRAS, CDKN1A
44	anti-apoptosis	GO:006916	INF	PIK3CA, NAIP, BRAF, , VEGFB, BNIP3
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	INF	KITLG, VTN, VEGFA, VEGFB, LIF, MTOR
46	negative regulation of cell proliferation	GO:008285	INF	SERPINE2, , BMP4, RARB, RAF1, LIF
47	cell-cell signaling	GO:007267	INF	SEMA3B, NAMPT, LALBA, S100A9, FZD1, FZD2
48	virus-host interaction	GO:019048	INF	PIK3R1, BUB1, BTRC, RB1, RBL1, VIM
49	induction of apoptosis	GO:006917	INF	BNIP3, USP7, BCL10, BCL2L11, BBC3, BAD
50	apoptotic process	GO:006915	INF	PDCD4, PCNT, BUB1, BUB1B, NBN, VIM

Molecular functions related to glioblastoma according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	20.7	KIT, VWF, SERPINF2, VEGFA, VEGFB, BNIP3
2	identical protein binding	GO:042802	17.8	PCNA, VIM, BNIP3, RAD51, RAF1, RASSF1
3	receptor binding	GO:005102	17.7	SERPINE2, SERPINE1, RARA, RARRES2, LIF, LGI1
4	protein kinase binding	GO:019901	15.7	KIF11, VIM, USF1, PAK1, PARK2, PAX6
5	protein heterodimerization activity	GO:046982	15.3	BRAF, VEGFA, VEGFB, BNIP3, MYC, BMP6
6	growth factor activity	GO:008083	15.2	KITLG, VEGFA, VEGFB, VEGFC, BMP4, BMP6
7	protein kinase activity	GO:004672	14.4	PIK3R4, PIK3CG, BUB1, BUB1B, BRAF, RAF1
8	cytokine activity	GO:005125	14.3	KITLG, NAMPT, VEGFA, BMP4, BMP6, LIF
9	ubiquitin protein ligase binding	GO:031625	13.3	RB1, BRCA1, USP7, BLZF1, BID, PARK2
10	protein tyrosine kinase activity	GO:004713	13.2	KIT, BMX, KDR, BCR, YES1, FYN
11	integrin binding	GO:005178	13.2	VWF, VTN, VCAM1, KDR, ITGA5, ITGA6
12	protease binding	GO:002020	12.0	KIT, VWF, SELL, SERPINF2, SERPINE1, BRCA2
13	signal transducer activity	GO:004871	11.5	VOPP1, BMX, LGALS1, CHKA, S100A9, AXIN1
14	enzyme binding	GO:019899	INF	BRCA1, , RARA, RAC1, USF1, BLZF1
15	transcription factor binding	GO:008134	INF	RB1, RBL1, NBN, , MYC, RARA
16	protein binding	GO:005515	INF	ZNF217, PIK3CD, PIK3CA, PIK3R2, PIK3R4, PIK3R1
17	ATP binding	GO:005524	INF	PIK3CD, PIK3CA, PIK3R4, PIK3CG, KIT, KIF11