GBM
MCID: GLB015
MIFTS: 64

Glioblastoma Multiforme (GBM) malady

Cancer diseases category

Summaries for Glioblastoma Multiforme

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derived from multiple cell types including astrocytes and oligondroctyes.

MalaCards: Glioblastoma Multiforme, also known as glioblastoma, is related to astrocytoma and meningioma. An important gene associated with Glioblastoma Multiforme is TRRAP (transformation/transcription domain-associated protein), and among its related pathways are Pathways in cancer and Rho Family GTPases. The compounds vegf and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone, and related mouse phenotypes are mortality/aging and immune system.

Wikipedia:63 Glioblastoma multiforme (GBM), WHO classification name \"glioblastoma\", is the most common and most... more...

Aliases & Classifications for Glioblastoma Multiforme

About this section
Sources:
42NIH Rare Diseases, 8Disease Ontology, 44Novoseek, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

glioblastoma multiforme 8 42 44
glioblastoma 8 42 10 44
adult glioblastoma multiforme 8 10
grade iv adult astrocytic tumor 8
primary glioblastoma multiforme 8
spongioblastoma multiforme 8
giant cell glioblastoma 42
glioblastoma nos 8
gliosarcoma 42
gbm 8


External Ids:

Disease Ontology8 DOID:3068
NCIt39 C9094, C3058
MeSH34 D005909

Related Diseases for Glioblastoma Multiforme

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Glioblastoma Multiforme via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.3HSPB2, PDGFB, IL13RA2, CDK4, HIF1A, NES
2meningioma30.7PDGFRB, PDGFB
3gliosarcoma30.7CDK4, PDGFRB
4malignant glioma30.7PDGFB, PDGFRB, E2F1, IL13RA2, CDK4, HIF1A
5melanoma30.5MGMT, E2F1, PDGFRB, PDGFB, HLA-B, MDM2
6brain cancer30.5EGFR, MDM2, MGMT
7giant cell glioblastoma30.5EGFR, MDM2
8adenocarcinoma30.4MDM2, HLA-B, MGMT, E2F1, PDGFRB, PDGFB
9breast cancer30.4HSPB2, E2F1, HLA-B, MDM2, PIK3CA, EGFR
10leukemia30.4PDGFB, PDGFRB, E2F1, MGMT, HLA-B, MDM2
11medulloblastoma30.3PDGFB, E2F1, MGMT, PIK3CA, NES, CDK4
12sarcoma30.3PDGFB, PDGFRB, E2F1, MDM2, NES, CDK4
13adenoma30.3E2F1, MGMT, HLA-B, NES, FIGF, CDK4
14meningitis30.3HLA-B
15retinoblastoma30.3CDK4, TRRAP, EGFR, PIK3CA, MDM2, E2F1
16lung adenocarcinoma30.1PDGFRB, E2F1, MGMT, PIK3CA, EGFR, FIGF
17pituitary adenoma30.1E2F1, MGMT, NES, CDK4
18leiomyosarcoma30.1CDK4, NES, MDM2, PDGFRB
19lung small cell carcinoma30.1E2F1, MGMT, PIK3CA, EGFR
20ataxia telangiectasia30.1E2F1, MDM2, PIK3CA
21acute leukemia30.1E2F1, PIK3CA
22hemangioblastoma30.1HIF1A, NES
23prostate cancer30.1E2F1, EGFR, HIF1A, CDK4
24thyroid cancer30.1PIK3CA
25malignant mesothelioma30.1CDK4, PDGFRB
26oligodendroglioma30.1EGFR, MGMT
27herpes simplex30.1HLA-B
28alzheimer's disease30.1HSPB2
29osteosarcoma30.1PDGFB, PDGFRB, E2F1, MDM2, HIF1A, CDK4
30colon cancer30.0PDGFRB, E2F1, MGMT, MDM2, PIK3CA, EGFR
31lung cancer30.0EGFR, PIK3CA
32hepatocellular carcinoma29.9PDGFB, E2F1, MGMT, MDM2, PIK3CA, HIF1A
33myeloid leukemia29.9E2F1, CDK4
34squamous cell carcinoma29.8CLDN5, HSPB2, PDGFB, E2F1, MGMT, HLA-B
35rhabdomyosarcoma29.8PDGFB, PDGFRB, MDM2, NES, CDK4
36pancreatic cancer29.8PDGFRB, MGMT, EGFR, NES
37chondrosarcoma29.8CDK4, MDM2, E2F1, PDGFRB
38brain glioma29.8CLDN5
39ovarian cancer29.7HSPB2, PDGFRB, E2F1, MDM2, PIK3CA, EGFR
40colorectal cancer29.7PDGFRB, E2F1, MGMT, MDM2, PIK3CA, EGFR
41fibrosarcoma29.7PDGFRB, E2F1, MDM2, NES, HIF1A
42cholangiocarcinoma29.7PIK3CA
43brain glioblastoma multiforme10.9
44glomerulonephritis10.6
45cerebritis10.5
46adult spinal cord glioblastoma multiforme10.4
47ganglioglioma10.3
48gliomatosis cerebri10.3
49pleomorphic xanthoastrocytoma10.3
50crescentic glomerulonephritis10.3

Graphical network of the top 20 diseases related to Glioblastoma Multiforme:



Diseases related to glioblastoma multiforme

Clinical Features for Glioblastoma Multiforme

About this section

Drugs & Therapeutics for Glioblastoma Multiforme

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Glioblastoma Multiforme

Drug clinical trials:

Search ClinicalTrials for Glioblastoma Multiforme

Search NIH Clinical Center for Glioblastoma Multiforme

Search CenterWatch for Glioblastoma Multiforme

Genetic Tests for Glioblastoma Multiforme

About this section

Anatomical Context for Glioblastoma Multiforme

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Glioblastoma Multiforme:

32
Brain, Endothelial, Bone, Spinal cord, Lung, Breast, Prostate, Temporal lobe, T cells, Thyroid, Liver, Colon, Pituitary

Animal Models for Glioblastoma Multiforme or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Glioblastoma Multiforme

About this section
Sources:
50PubMed
See all sources

Articles related to Glioblastoma Multiforme:

(show top 50)    (show all 569)
idTitleAuthorsYear
1
Recurrent glioblastoma multiforme versus radiation injury: a multiparametric 3-T MR approach. (24408041)
2014
2
Glioblastoma multiforme: relationship to subventricular zone and recurrence. (24199814)
2013
3
Plastic reshaping of cortical language areas evaluated by navigated transcranial magnetic stimulation in a surgical case of glioblastoma multiforme. (23911000)
2013
4
ApoE enhances nanodisk-mediated curcumin delivery to glioblastoma multiforme cells. (23879635)
2013
5
A husband and a wife with simultaneous presentation of glioblastoma multiforme: a case report. (24348390)
2013
6
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
7
Cluster headache and parietal glioblastoma multiforme. (22735247)
2012
8
CD133 as a marker for regulation and potential for targeted therapies in glioblastoma multiforme. (22748652)
2012
9
Cytomegalovirus infection in early childhood may be protective against glioblastoma multiforme, while later infection is a risk factor. (22385772)
2012
10
Function of carbonic anhydrase IX in glioblastoma multiforme. (23074198)
2012
11
Turcot syndrome: a synchronous clinical presentation of glioblastoma multiforme and adenocarcinoma of the colon. (23119205)
2012
12
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. (19784869)
2010
13
An unusual loss of EGFR gene copy in glioblastoma multiforme in a child: a case report and analysis of a successfully derived HGG-02 cell line. (20195615)
2010
14
Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. (20412570)
2010
15
FHIT gene sequence variants and reduced Fhit protein expression in glioblastoma multiforme. (19760177)
2010
16
NFAT and AP1 are essential for the expression of a glioblastoma multiforme related IL-13Ra2 transcript. (20448330)
2010
17
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. (19074898)
2008
18
Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests. (18559551)
2008
19
Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. (18366728)
2008
20
The role of a single nucleotide polymorphism of MDM2 in glioblastoma multiforme. (18976073)
2008
21
Epidermal growth factor receptor pathway gene expressions and biological response of glioblastoma multiforme cell lines to erlotinib. (19189656)
2008
22
Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker. (18400046)
2008
23
Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. (18955445)
2008
24
Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme. (17504929)
2007
25
Organotypic distribution of stem cell markers in formalin-fixed brain harboring glioblastoma multiforme. (17516028)
2007
26
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. (17272309)
2007
27
Glioblastoma multiforme after stereotactic radiotherapy for acoustic neuroma: case report and review of the literature. (17704364)
2007
28
Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations. (17498554)
2007
29
Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme. (18056196)
2007
30
Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation. (16575014)
2006
31
Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM). (16773218)
2006
32
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. (16627485)
2006
33
PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. (16007122)
2005
34
The transformation of pediatric gliomatosis cerebri to cerebellar glioblastoma multiforme presenting as supra- and infratentorial acute disseminated encephalomyelitis. Case report. (16206737)
2005
35
Decreased expression of heparanase in glioblastoma multiforme. (15796387)
2005
36
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines. (16175187)
2005
37
Immunotoxin treatment targeted to the high-molecular-weight melanoma-associated antigen prolonging the survival of immunodeficient rats with invasive intracranial human glioblastoma multiforme. (15086240)
2004
38
Expression of cytoplasmic-domain substituted epidermal growth factor receptor inhibits tumorigenicity of EGFR-overexpressed human glioblastoma multiforme. (14767543)
2004
39
Prognostic relevance of MAPK expression in glioblastoma multiforme. (12888899)
2003
40
Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme? (11706939)
2001
41
Angiogenic effect of thymidine phosphorylase on macrophages in glioblastoma multiforme. (11455962)
2001
42
Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors. (10728679)
2000
43
Somatic mutations of PTEN in glioblastoma multiforme. (9331071)
1997
44
Amplification of the cyclin-dependent kinase 4 (CDK4) gene is associated with high cdk4 protein levels in glioblastoma multiforme. (8811128)
1996
45
Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics. (8847560)
1996
46
Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue. (7535788)
1995
47
Heterogeneity, polyploidy, aneusomy, and 9p deletion in human glioblastoma multiforme. (7553582)
1995
48
Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme. (8168112)
1994
49
Gliomatosis cerebri with formation of a glioblastoma multiform. Study and follow-up by magnetic resonance and computed tomography. (2848658)
1988
50
Glioblastoma multiforme masquerading as a pleomorphic xanthoastrocytoma. (2844403)
1988

Genetic Variations for Glioblastoma Multiforme

About this section

Expression for genes affiliated with Glioblastoma Multiforme

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Glioblastoma Multiforme

Search GEO for disease gene expression data for Glioblastoma Multiforme.

Pathways for genes affiliated with Glioblastoma Multiforme

About this section
Sources:
29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 52R&D Systems, 59Tocris Bioscience, 55SinoBiological, 49PharmGKB
See all sources

Pathways related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.5FIGF, PDGFB, PDGFRB, E2F1, MDM2, HIF1A
2
Hide members
11.5MDM2, HIF1A, IL13RA2, EGFR, FIGF, E2F1
311.3PIK3CA, PDGFB, E2F1, HLA-B, PDGFRB, TRRAP
411.3PDGFRB, PDGFB, CDK4, MDM2, PIK3CA, EGFR
511.3PDGFRB, E2F1, MGMT, MDM2, EGFR, CDK4
611.2PDGFRB, MDM2, PIK3CA, EGFR, HIF1A, PDGFB
7
Hide members
11.2PIK3CA, PDGFB, EGFR, PDGFRB, HLA-B, MDM2
8
Hide members
11.2MDM2, PIK3CA, HLA-B, PDGFRB, PDGFB, EGFR
911.2PIK3CA, PDGFB, MDM2, E2F1, PDGFRB, EGFR
10
Hide members
11.2PDGFRB, EGFR, PDGFB, FIGF, IL13RA2, MDM2
11
Hide members
11.1PDGFB, PIK3CA, EGFR, HIF1A, PDGFRB
12
Hide members
11.1EGFR, PIK3CA, PDGFB, PDGFRB, MDM2
13
Hide members
11.1EGFR, MDM2, PDGFRB, PDGFB, PIK3CA
14
Hide members
11.1PIK3CA, MDM2, PDGFRB, EGFR, PDGFB
1511.1HIF1A, EGFR, HSPB2, MDM2, PIK3CA
16
Hide members
11.1EGFR, E2F1, PIK3CA, CDK4, MDM2
1711.1CDK4, PIK3CA, EGFR, MDM2, E2F1
18
Hide members
11.1MGMT, E2F1, CDK4, TRRAP, MDM2
19
Hide members
11.1EGFR, FIGF, PDGFRB, PDGFB, PIK3CA
2011.1CDK4, E2F1, PDGFRB, EGFR, MDM2
21
Hide members
11.1FIGF, EGFR, PDGFRB, PDGFB, MDM2
2210.9CDK4, MDM2, PIK3CA, HLA-B
23
Hide members
10.9EGFR, PDGFRB, MDM2, PIK3CA
2410.9PDGFRB, PDGFB, PIK3CA, HIF1A
25
Hide members
10.9EGFR, PIK3CA, PDGFB, PDGFRB
2610.9HSPB2, PIK3CA, MDM2, HLA-B
27
Hide members
10.9CDK4, PIK3CA, MDM2, E2F1
28
Hide members
10.9MDM2, E2F1, HIF1A, CDK4
2910.9EGFR, CDK4, E2F1, MDM2
30
Hide members
10.9MGMT, CDK4, MDM2, E2F1
31
Hide members
10.9EGFR, HSPB2, PDGFRB, PDGFB
32
Hide members
10.9PDGFRB, E2F1, PDGFB, MDM2
33
Hide members
10.9E2F1, FIGF, CDK4, PDGFB
34
Transcription Androgen Receptor nuclear signaling
Hide members
10.8PIK3CA, MDM2, EGFR
3510.8PDGFB, HIF1A, PIK3CA
36
Hide members
10.8PDGFRB, PIK3CA, EGFR
3710.8EGFR, PIK3CA, PDGFRB
3810.8PDGFRB, PIK3CA, EGFR
39
G-protein signaling H-RAS regulation pathway
Hide members
10.8PDGFRB, PIK3CA, PDGFB
40
Cytoskeleton remodeling Role of PDGFs in cell migration
Hide members
10.8PDGFRB, PIK3CA, PDGFB
41
Hide members
10.8PIK3CA, FIGF, EGFR
42
Development Ligand-dependent activation of the ESR1/AP-1 pathway
Hide members
10.8E2F1, EGFR, HIF1A
4310.8CDK4, PIK3CA, E2F1
4410.8PIK3CA, CDK4, E2F1
4510.8FIGF, MDM2, HIF1A
46
Hide members
10.8MDM2, E2F1, CDK4
47
Transcription P53 signaling pathway
Hide members
10.8E2F1, MDM2, CDK4
48
Hide members
10.8IL13RA2, FIGF, PDGFB
49
Hide members
10.7PDGFRB, PDGFB
5010.7PDGFRB, PDGFB

Compounds for genes affiliated with Glioblastoma Multiforme

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1vegf4412.3MGMT, NES, EGFR, PIK3CA, MDM2, E2F1
2tyrosine4412.3NES, CDK4, MDM2, HIF1A, HLA-B, FIGF
3progesterone44 59 28 11 2416.1FIGF, NES, EGFR, PIK3CA, MGMT, E2F1
4oligonucleotide4412.1MDM2, PDGFB, CLDN5, CDK4, HIF1A, HLA-B
5nitric oxide44 11 2414.1PDGFB, MGMT, E2F1, HLA-B, MDM2, PIK3CA
6serine4412.0EGFR, PIK3CA, CDK4, MDM2, HLA-B, E2F1
7paraffin4412.0HIF1A, CDK4, NES, EGFR, MDM2, HLA-B
8cisplatin44 49 59 1115.0HSPB2, PDGFRB, E2F1, HIF1A, CDK4, EGFR
9retinoic acid44 2412.9E2F1, PDGFRB, EGFR, MGMT, NES, HLA-B
105fluorouracil4411.9PIK3CA, MDM2, MGMT, E2F1, CDK4, PDGFRB
11agar4411.9PDGFB, PIK3CA, PDGFRB, E2F1, CDK4, HIF1A
12doxorubicin44 49 1113.8PIK3CA, EGFR, HIF1A, CDK4, MGMT, E2F1
13testosterone44 59 11 2414.8CDK4, PIK3CA, HIF1A, HLA-B, E2F1, PDGFRB
14paclitaxel44 49 1113.7HIF1A, CDK4, EGFR, PIK3CA, E2F1, PDGFRB
15rapamycin4411.7MDM2, CDK4, HIF1A, PDGFRB, E2F1, EGFR
16pd 98,0594411.7CDK4, HIF1A, PDGFB, EGFR, HSPB2, MDM2
17genistein44 28 59 2 11 2416.7PIK3CA, CDK4, HIF1A, MDM2, MGMT, PDGFRB
18thymidine44 2412.7PDGFB, PIK3CA, MDM2, MGMT, E2F1, HIF1A
19flavopiridol44 1112.6E2F1, CDK4, PDGFRB, HIF1A, EGFR, MDM2
20oxygen44 2412.6E2F1, NES, MDM2, FIGF, CDK4, HSPB2
21bromodeoxyuridine4411.6CDK4, PIK3CA, PDGFRB, E2F1, PDGFB, NES
22phosphotyrosine4411.6CDK4, PIK3CA, PDGFRB, EGFR, PDGFB, HLA-B
23phosphatidylinositol4411.5PDGFRB, PIK3CA, CDK4, HIF1A, EGFR, MDM2
24ly2940024411.5HIF1A, MDM2, EGFR, PIK3CA, CDK4, PDGFRB
25proline4411.5MDM2, PDGFRB, MGMT, HLA-B, HIF1A, CDK4
26trastuzumab44 49 1113.5MDM2, PIK3CA, EGFR, HIF1A, CDK4
27carboplatin44 49 1113.5MGMT, MDM2, EGFR, HIF1A, CDK4
28gefitinib44 49 1113.5EGFR, MDM2, CDK4, PDGFRB, PIK3CA
29dexamethasone44 49 28 1114.5PIK3CA, PDGFB, MGMT, MDM2, HIF1A, CDK4
30thymidylate4411.4MGMT, CDK4, E2F1, MDM2, EGFR
31docetaxel44 49 59 1114.4HIF1A, EGFR, PIK3CA, MDM2, PDGFRB
32camptothecin44 59 1113.4MDM2, HIF1A, E2F1, CDK4, MGMT
33imatinib44 49 1113.4EGFR, PIK3CA, PDGFRB, MDM2, PDGFB
34tacrolimus44 49 1113.4HLA-B, PDGFB, PIK3CA, HIF1A, CDK4
35glucose4411.3HIF1A, PDGFRB, PIK3CA, MGMT
36vincristine44 49 1113.3HIF1A, HSPB2, E2F1, MGMT
37topotecan44 1112.3PDGFRB, HIF1A, EGFR, MGMT
38irinotecan44 49 1113.2MDM2, HIF1A, EGFR, MGMT
39adpribose4411.2CDK4, EGFR, PIK3CA, MDM2
40h2o24411.2PIK3CA, MDM2, PDGFRB, HSPB2, HLA-B, HIF1A
41gemcitabine44 49 1113.1EGFR, E2F1, PDGFRB, HIF1A
42geldanamycin44 49 59 1114.1MDM2, EGFR, CDK4, HIF1A
43su54164411.1HIF1A, EGFR, PDGFRB
44lactacystin4411.1E2F1, MDM2, HIF1A, CDK4
45tamoxifen44 49 28 1114.1HIF1A, PIK3CA, EGFR, FIGF, E2F1
46temozolomide44 1111.9EGFR, NES, MGMT
47etoposide44 49 59 1113.9MDM2, HIF1A
48sunitinib44 49 1112.9HIF1A, EGFR, PDGFRB
49noxa4410.5E2F1, MDM2, HIF1A
50cycloheximide4410.5PDGFB

GO Terms for genes affiliated with Glioblastoma Multiforme

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.5CDK4, FIGF, EGFR, MDM2, PDGFRB, PDGFB
2innate immune responseGO:04508711.4PDGFB, PDGFRB, HLA-B, MDM2, PIK3CA, EGFR
3phosphatidylinositol-mediated signalingGO:04801511.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
4fibroblast growth factor receptor signaling pathwayGO:00854311.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
5Fc-epsilon receptor signaling pathwayGO:03809511.4EGFR, PIK3CA, MDM2, PDGFRB, PDGFB
6epidermal growth factor receptor signaling pathwayGO:00717311.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
7neurotrophin TRK receptor signaling pathwayGO:04801111.4EGFR, PIK3CA, MDM2, PDGFRB, PDGFB
8positive regulation of fibroblast proliferationGO:04814611.3CDK4, EGFR, E2F1, PDGFB
9embryonic placenta developmentGO:00189211.1PDGFB, EGFR, HIF1A
10positive regulation of MAP kinase activityGO:04340611.1PDGFB, PDGFRB, EGFR
11response to toxic substanceGO:00963611.0PDGFRB, MGMT, CDK4
12metanephric glomerular mesangial cell proliferation involved in metanephros developmentGO:07226211.0PDGFB, PDGFRB
13positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayGO:03579311.0PDGFRB, PDGFB
14retina vasculature development in camera-type eyeGO:06129811.0HIF1A, PDGFRB
15cellular response to hypoxiaGO:07145610.9HIF1A, MDM2, E2F1
16positive regulation of DNA biosynthetic processGO:200057310.9PDGFRB, PDGFB
17positive regulation of calcium ion importGO:09028010.9PDGFB, PDGFRB
18positive regulation of chemotaxisGO:05092110.9PDGFB, PDGFRB
19response to drugGO:04249310.8PDGFB, MGMT, MDM2, CDK4
20regulation of peptidyl-tyrosine phosphorylationGO:05073010.8PDGFRB, EGFR
21positive regulation of smooth muscle cell migrationGO:01491110.7PDGFB, PDGFRB
22response to hyperoxiaGO:05509310.7CDK4, PDGFRB
23positive regulation of ERK1 and ERK2 cascadeGO:07037410.5EGFR, PDGFRB, PDGFB

Molecular functions related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.7PDGFRB, PDGFB
2platelet-derived growth factor receptor bindingGO:00516110.5FIGF, PDGFRB, PDGFB

Products for genes affiliated with Glioblastoma Multiforme

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glioblastoma Multiforme

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet