GBM
MCID: GLB015
MIFTS: 57

Glioblastoma Multiforme (GBM) malady

Summaries for Glioblastoma Multiforme

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derived from multiple cell types including astrocytes and oligondroctyes.

MalaCards: Glioblastoma Multiforme, also known as glioblastoma, is related to astrocytoma and anaplastic astrocytoma. An important gene associated with Glioblastoma Multiforme is TRRAP (transformation/transcription domain-associated protein), and among its related pathways are Pathways in cancer and Rho Family GTPases. The compounds vegf and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and immune system.

Wikipedia:64 Glioblastoma multiforme (GBM), WHO classification name \"glioblastoma\", is the most common and most... more...

Aliases & Classifications for Glioblastoma Multiforme

Sources:
43NIH Rare Diseases, 8Disease Ontology, 45Novoseek, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

glioblastoma multiforme 8 43 45
glioblastoma 8 43 10 45
adult glioblastoma multiforme 8 10
grade iv adult astrocytic tumor 8
primary glioblastoma multiforme 8
spongioblastoma multiforme 8
giant cell glioblastoma 43
glioblastoma nos 8
gliosarcoma 43
gbm 8


External Ids:

Disease Ontology8 DOID:3068
NCIt40 C9094, C3058
MeSH35 D005909

Related Diseases for Glioblastoma Multiforme

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Glioblastoma Multiforme via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.4HSPB2, PDGFB, IL13RA2, CDK4, HIF1A, NES
2anaplastic astrocytoma31.3PDGFRB, MGMT, MDM2, EGFR, NES, CDK4
3gliosarcoma30.7CDK4, PDGFRB
4brain cancer30.5EGFR, MDM2, MGMT
5giant cell glioblastoma30.5EGFR, MDM2
6adenocarcinoma30.4MDM2, HLA-B, MGMT, E2F1, PDGFRB, PDGFB
7adenoma30.4E2F1, MGMT, HLA-B, NES, FIGF, CDK4
8pilocytic astrocytoma30.4PDGFRB, MGMT, NES, CDK4
9ataxia telangiectasia30.2E2F1, MDM2, PIK3CA
10acute leukemia30.2E2F1, PIK3CA
11thyroid cancer30.2PIK3CA
12alzheimer's disease30.2HSPB2
13ependymoma30.1MGMT, MDM2, EGFR, NES
14anaplastic oligodendroglioma29.9CDK4, EGFR, MDM2, MGMT
15squamous cell carcinoma29.9CLDN5, HSPB2, PDGFB, E2F1, MGMT, HLA-B
16brain glioma29.9CLDN5
17anaplastic ependymoma29.9MDM2
18colorectal cancer29.7PDGFRB, E2F1, MGMT, MDM2, PIK3CA, EGFR
19brain glioblastoma multiforme10.9
20hypoxia10.6
21adult spinal cord glioblastoma multiforme10.4
22turcot syndrome10.4
23ganglioglioma10.4
24gliomatosis cerebri10.4
25pleomorphic xanthoastrocytoma10.4
26cytomegalovirus infection10.4
27crescentic glomerulonephritis10.3
28rapidly progressive glomerulonephritis10.3
29goodpasture syndrome10.3
30transitional meningioma10.3
31muir-torre syndrome10.3
32glioblastoma mesenchymal subtype10.3
33acoustic neuroma10.3
34aplastic anemia10.3
35glioma somatic10.3
36glioblastoma 310.3
37adult brainstem gliosarcoma10.2
38wilms tumor10.2
39neurofibromatosis10.2
40wegener's granulomatosis10.2
41good syndrome10.2
42vasculitis10.2
43choroid plexus papilloma10.1
44gemistocytic astrocytoma10.1
45subependymal giant cell astrocytoma10.1
46hemorrhage, intracerebral10.1
47cerebral angioma10.1
48sebaceous adenoma10.1
49dysembryoplastic neuroepithelial tumor10.1
50gaucher's disease10.1

Graphical network of the top 20 diseases related to Glioblastoma Multiforme:



Diseases related to glioblastoma multiforme

Clinical Features for Glioblastoma Multiforme

Drugs & Therapeutics for Glioblastoma Multiforme

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Glioblastoma Multiforme

Drug clinical trials:

Search ClinicalTrials for Glioblastoma Multiforme

Search NIH Clinical Center for Glioblastoma Multiforme

Search CenterWatch for Glioblastoma Multiforme

Genetic Tests for Glioblastoma Multiforme

Anatomical Context for Glioblastoma Multiforme

Animal Models for Glioblastoma Multiforme or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Glioblastoma Multiforme:

37 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.7FIGF, MDM2, CLDN5, CDK4, HIF1A, TRRAP
2MP:000538712.1PIK3CA, EGFR, FIGF, HIF1A, CDK4, IL13RA2
3MP:000538512.0EGFR, PIK3CA, FIGF, MDM2, PDGFRB, PDGFB
4MP:000538412.0EGFR, CDK4, GLIPR1, HIF1A, NES, HSPB2
5MP:000537812.0HSPB2, PDGFRB, E2F1, PIK3CA, EGFR, NES
6MP:000200611.8GLIPR1, CDK4, E2F1, EGFR, PIK3CA, MDM2
7MP:000539711.6PDGFRB, MDM2, EGFR, CDK4, E2F1, HIF1A
8MP:000536911.5PDGFB, PDGFRB, E2F1, HIF1A, MDM2, HSPB2
9MP:000538611.5CDK4, HIF1A, FIGF, NES, PIK3CA, HLA-B
10MP:000363111.5E2F1, HSPB2, PDGFB, EBF3, CDK4, CLDN5
11MP:000538111.4CDK4, HIF1A, EGFR, HSPB2, MDM2, E2F1
12MP:001077111.4CDK4, HIF1A, MDM2, E2F1, PDGFB, PIK3CA
13MP:000539111.2HIF1A, PDGFB, E2F1, EGFR
14MP:000538011.1PDGFB, TRRAP, NES
15MP:000537611.1PDGFRB, IL13RA2, MGMT, CDK4, PIK3CA, PDGFB
16MP:000537511.0PDGFRB, FIGF, HSPB2
17MP:000536710.8HIF1A, EGFR, PDGFB
18MP:000537910.8E2F1, MGMT, PDGFRB, PIK3CA, CDK4

Publications for Glioblastoma Multiforme

Sources:
51PubMed
See all sources

Articles related to Glioblastoma Multiforme:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
The Identification of Mitochondrial DNA Variants in Glioblastoma Multiforme. (24383468)
2014
2
Expression of insulin-like growth factor binding protein-2 (IGFBP-2) gene in negative and positive human cytomegalovirus glioblastoma multiforme tissues. (24352760)
2014
3
Correction: Saponin 1 Induces Apoptosis and Suppresses NF-I_B-Mediated Survival Signaling in Glioblastoma Multiforme (GBM). (24427248)
2014
4
Temozolomide and Radiotherapy for Newly Diagnosed Glioblastoma Multiforme: A Systematic Review. (24328555)
2013
5
Targeted induction of apoptosis in glioblastoma multiforme cells by an MRP3-specific TRAIL fusion protein in vitro. (24272336)
2013
6
Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme. (24100685)
2013
7
An extremely rare case of glioblastoma multiforme of the spinal cord. (24247921)
2013
8
Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor. (23977270)
2013
9
Saponin 1 induces apoptosis and suppresses NF-I_B-mediated survival signaling in glioblastoma multiforme (GBM). (24278406)
2013
10
EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. (23410976)
2013
11
DNA aptamers that target human glioblastoma multiforme cells overexpressing epidermal growth factor receptor variant III in vitro. (24304919)
2013
12
SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme. (24278465)
2013
13
Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis. (22972189)
2012
14
PARP-1 protein expression in glioblastoma multiforme. (22472897)
2012
15
Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. (22253878)
2012
16
Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. (20354191)
2010
17
Repeated hepatocyte growth factor neutralizing antibody treatment leads to HGF/SF unresponsiveness in human glioblastoma multiforme cells. (19910109)
2010
18
XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC. (20127563)
2010
19
Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme. (19672263)
2009
20
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells. (19996278)
2009
21
Paradoxical expression of anti-apoptotic and MRP genes on cancer stem-like cell isolated from TJ905 glioblastoma multiforme cell line. (18443953)
2008
22
Partial biological characterization of cancer stem-like cell line (WJ(2)) of human glioblastoma multiforme. (18350379)
2008
23
Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib. (19189657)
2008
24
Identification of survival-related genes of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma multiforme. (18260157)
2008
25
Imaging immune response in vivo: cytolytic action of genetically altered T cells directed to glioblastoma multiforme. (18559603)
2008
26
Glutathione peroxidase, glutathione reductase and protein oxidation in patients with glioblastoma multiforme and transitional meningioma. (17457608)
2007
27
Nestin expression in the cell lines derived from glioblastoma multiforme. (16457706)
2006
28
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. (17111679)
2006
29
The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia. (16217754)
2006
30
Phase 2 trial of radiation plus high-dose tamoxifen for glioblastoma multiforme: RTOG protocol BR-0021. (16443947)
2006
31
TRAIL-receptor expression is an independent prognostic factor for survival in patients with a primary glioblastoma multiforme. (16544055)
2006
32
Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study. (15701286)
2005
33
A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme. (15937647)
2005
34
Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme. (15831234)
2005
35
Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). (15531918)
2005
36
Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes. (14965379)
2004
37
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. (12466961)
2002
38
Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme. (12005388)
2002
39
Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin. (12070669)
2002
40
The prognostic value of tumor markers in patients with glioblastoma multiforme: analysis of 32 patients and review of the literature. (11859975)
2001
41
Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy. (10730637)
2000
42
Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme. (10965803)
2000
43
Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker. (11014540)
2000
44
Therapeutic synergy of TNP-470 and ionizing radiation: effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenografts. (10741723)
2000
45
Aberrant p21 regulation in radioresistant primary glioblastoma multiforme cells bearing wild-type p53. (11059670)
2000
46
The effects of anticancer drugs in combination with nimodipine and verapamil on cultured cells of glioblastoma multiforme. (10622452)
1999
47
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. (10213484)
1999
48
Evaluation of epithelial and keratin markers in glioblastoma multiforme: an immunohistochemical study. (10506444)
1999
49
Subsets of glioblastoma multiforme defined by molecular genetic analysis. (8269081)
1993
50
Comparison of cytologic composition with microfluorometric DNA analysis of the glioblastoma multiforme and anaplastic astrocytoma. (2438028)
1987

Genetic Variations for Glioblastoma Multiforme

Expression for genes affiliated with Glioblastoma Multiforme

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glioblastoma Multiforme

Search GEO for disease gene expression data for Glioblastoma Multiforme.

Pathways for genes affiliated with Glioblastoma Multiforme

Sources:
30KEGG, 52QIAGEN, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology, 53R&D Systems, 60Tocris Bioscience, 56SinoBiological, 50PharmGKB
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Pathways related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.5FIGF, PDGFB, PDGFRB, E2F1, MDM2, HIF1A
2
Hide members
11.5MDM2, HIF1A, IL13RA2, EGFR, FIGF, E2F1
311.3PIK3CA, PDGFB, E2F1, HLA-B, PDGFRB, TRRAP
411.3PDGFRB, PDGFB, CDK4, MDM2, PIK3CA, EGFR
511.3PDGFRB, E2F1, MGMT, MDM2, EGFR, CDK4
611.2PDGFRB, MDM2, PIK3CA, EGFR, HIF1A, PDGFB
7
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11.2PIK3CA, PDGFB, EGFR, PDGFRB, HLA-B, MDM2
8
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11.2MDM2, PIK3CA, HLA-B, PDGFRB, PDGFB, EGFR
911.2PIK3CA, PDGFB, MDM2, E2F1, PDGFRB, EGFR
10
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11.2PDGFRB, EGFR, PDGFB, FIGF, IL13RA2, MDM2
11
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11.1PDGFB, PIK3CA, EGFR, HIF1A, PDGFRB
12
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11.1EGFR, PIK3CA, PDGFB, PDGFRB, MDM2
13
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11.1EGFR, MDM2, PDGFRB, PDGFB, PIK3CA
14
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11.1PIK3CA, MDM2, PDGFRB, EGFR, PDGFB
1511.1HIF1A, EGFR, HSPB2, MDM2, PIK3CA
16
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11.1EGFR, E2F1, PIK3CA, CDK4, MDM2
1711.1CDK4, PIK3CA, EGFR, MDM2, E2F1
18
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11.1MGMT, E2F1, CDK4, TRRAP, MDM2
19
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11.1EGFR, FIGF, PDGFRB, PDGFB, PIK3CA
2011.1CDK4, E2F1, PDGFRB, EGFR, MDM2
21
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11.1FIGF, EGFR, PDGFRB, PDGFB, MDM2
2210.9CDK4, MDM2, PIK3CA, HLA-B
23
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10.9EGFR, PDGFRB, MDM2, PIK3CA
2410.9PDGFRB, PDGFB, PIK3CA, HIF1A
25
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10.9EGFR, PIK3CA, PDGFB, PDGFRB
2610.9HSPB2, PIK3CA, MDM2, HLA-B
27
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10.9CDK4, PIK3CA, MDM2, E2F1
28
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10.9MDM2, E2F1, HIF1A, CDK4
2910.9EGFR, CDK4, E2F1, MDM2
30
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10.9MGMT, CDK4, MDM2, E2F1
31
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10.9EGFR, HSPB2, PDGFRB, PDGFB
32
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10.9PDGFRB, E2F1, PDGFB, MDM2
33
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10.9E2F1, FIGF, CDK4, PDGFB
34
Transcription Androgen Receptor nuclear signaling
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10.8PIK3CA, MDM2, EGFR
3510.8PDGFB, HIF1A, PIK3CA
36
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10.8PDGFRB, PIK3CA, EGFR
3710.8EGFR, PIK3CA, PDGFRB
3810.8PDGFRB, PIK3CA, EGFR
39
G-protein signaling H-RAS regulation pathway
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10.8PDGFRB, PIK3CA, PDGFB
40
Cytoskeleton remodeling Role of PDGFs in cell migration
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10.8PDGFRB, PIK3CA, PDGFB
41
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10.8PIK3CA, FIGF, EGFR
42
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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10.8E2F1, EGFR, HIF1A
4310.8CDK4, PIK3CA, E2F1
4410.8PIK3CA, CDK4, E2F1
4510.8FIGF, MDM2, HIF1A
46
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10.8MDM2, E2F1, CDK4
47
Transcription P53 signaling pathway
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10.8E2F1, MDM2, CDK4
48
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10.8IL13RA2, FIGF, PDGFB
49
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10.7PDGFRB, PDGFB
5010.7PDGFRB, PDGFB

Compounds for genes affiliated with Glioblastoma Multiforme

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1vegf4512.3MGMT, NES, EGFR, PIK3CA, MDM2, E2F1
2tyrosine4512.3NES, CDK4, MDM2, HIF1A, HLA-B, FIGF
3progesterone45 60 29 11 2416.1FIGF, NES, EGFR, PIK3CA, MGMT, E2F1
4oligonucleotide4512.1MDM2, PDGFB, CLDN5, CDK4, HIF1A, HLA-B
5nitric oxide45 11 2414.1PDGFB, MGMT, E2F1, HLA-B, MDM2, PIK3CA
6serine4512.0EGFR, PIK3CA, CDK4, MDM2, HLA-B, E2F1
7paraffin4512.0HIF1A, CDK4, NES, EGFR, MDM2, HLA-B
8cisplatin45 50 60 1115.0HSPB2, PDGFRB, E2F1, HIF1A, CDK4, EGFR
9retinoic acid45 2412.9E2F1, PDGFRB, EGFR, MGMT, NES, HLA-B
105fluorouracil4511.9PIK3CA, MDM2, MGMT, E2F1, CDK4, PDGFRB
11agar4511.9PDGFB, PIK3CA, PDGFRB, E2F1, CDK4, HIF1A
12doxorubicin45 50 1113.8PIK3CA, EGFR, HIF1A, CDK4, MGMT, E2F1
13testosterone45 60 11 2414.8CDK4, PIK3CA, HIF1A, HLA-B, E2F1, PDGFRB
14paclitaxel45 50 1113.7HIF1A, CDK4, EGFR, PIK3CA, E2F1, PDGFRB
15rapamycin4511.7MDM2, CDK4, HIF1A, PDGFRB, E2F1, EGFR
16pd 98,0594511.7CDK4, HIF1A, PDGFB, EGFR, HSPB2, MDM2
17genistein45 29 60 2 11 2416.7PIK3CA, CDK4, HIF1A, MDM2, MGMT, PDGFRB
18thymidine45 2412.7PDGFB, PIK3CA, MDM2, MGMT, E2F1, HIF1A
19flavopiridol45 1112.6E2F1, CDK4, PDGFRB, HIF1A, EGFR, MDM2
20oxygen45 2412.6E2F1, NES, MDM2, FIGF, CDK4, HSPB2
21bromodeoxyuridine4511.6CDK4, PIK3CA, PDGFRB, E2F1, PDGFB, NES
22phosphotyrosine4511.6CDK4, PIK3CA, PDGFRB, EGFR, PDGFB, HLA-B
23phosphatidylinositol4511.5PDGFRB, PIK3CA, CDK4, HIF1A, EGFR, MDM2
24ly2940024511.5HIF1A, MDM2, EGFR, PIK3CA, CDK4, PDGFRB
25proline4511.5MDM2, PDGFRB, MGMT, HLA-B, HIF1A, CDK4
26trastuzumab45 50 1113.5MDM2, PIK3CA, EGFR, HIF1A, CDK4
27carboplatin45 50 1113.5MGMT, MDM2, EGFR, HIF1A, CDK4
28gefitinib45 50 1113.5EGFR, MDM2, CDK4, PDGFRB, PIK3CA
29dexamethasone45 50 29 1114.5PIK3CA, PDGFB, MGMT, MDM2, HIF1A, CDK4
30thymidylate4511.4MGMT, CDK4, E2F1, MDM2, EGFR
31docetaxel45 50 60 1114.4HIF1A, EGFR, PIK3CA, MDM2, PDGFRB
32camptothecin45 60 1113.4MDM2, HIF1A, E2F1, CDK4, MGMT
33imatinib45 50 1113.4EGFR, PIK3CA, PDGFRB, MDM2, PDGFB
34tacrolimus45 50 1113.4HLA-B, PDGFB, PIK3CA, HIF1A, CDK4
35glucose4511.3HIF1A, PDGFRB, PIK3CA, MGMT
36vincristine45 50 1113.3HIF1A, HSPB2, E2F1, MGMT
37topotecan45 1112.3PDGFRB, HIF1A, EGFR, MGMT
38irinotecan45 50 1113.2MDM2, HIF1A, EGFR, MGMT
39adpribose4511.2CDK4, EGFR, PIK3CA, MDM2
40h2o24511.2PIK3CA, MDM2, PDGFRB, HSPB2, HLA-B, HIF1A
41gemcitabine45 50 1113.1EGFR, E2F1, PDGFRB, HIF1A
42geldanamycin45 50 60 1114.1MDM2, EGFR, CDK4, HIF1A
43su54164511.1HIF1A, EGFR, PDGFRB
44lactacystin4511.1E2F1, MDM2, HIF1A, CDK4
45tamoxifen45 50 29 1114.1HIF1A, PIK3CA, EGFR, FIGF, E2F1
46temozolomide45 1111.9EGFR, NES, MGMT
47etoposide45 50 60 1113.9MDM2, HIF1A
48sunitinib45 50 1112.9HIF1A, EGFR, PDGFRB
49noxa4510.5E2F1, MDM2, HIF1A
50cycloheximide4510.5PDGFB

GO Terms for genes affiliated with Glioblastoma Multiforme

Sources:
16Gene Ontology
See all sources

Biological processes related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.5CDK4, FIGF, EGFR, MDM2, PDGFRB, PDGFB
2innate immune responseGO:04508711.4PDGFB, PDGFRB, HLA-B, MDM2, PIK3CA, EGFR
3phosphatidylinositol-mediated signalingGO:04801511.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
4fibroblast growth factor receptor signaling pathwayGO:00854311.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
5Fc-epsilon receptor signaling pathwayGO:03809511.4EGFR, PIK3CA, MDM2, PDGFRB, PDGFB
6epidermal growth factor receptor signaling pathwayGO:00717311.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
7neurotrophin TRK receptor signaling pathwayGO:04801111.4EGFR, PIK3CA, MDM2, PDGFRB, PDGFB
8positive regulation of fibroblast proliferationGO:04814611.3CDK4, EGFR, E2F1, PDGFB
9embryonic placenta developmentGO:00189211.1PDGFB, EGFR, HIF1A
10positive regulation of MAP kinase activityGO:04340611.1PDGFB, PDGFRB, EGFR
11response to toxic substanceGO:00963611.0PDGFRB, MGMT, CDK4
12metanephric glomerular mesangial cell proliferation involved in metanephros developmentGO:07226211.0PDGFB, PDGFRB
13positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayGO:03579311.0PDGFRB, PDGFB
14retina vasculature development in camera-type eyeGO:06129811.0HIF1A, PDGFRB
15cellular response to hypoxiaGO:07145610.9HIF1A, MDM2, E2F1
16positive regulation of DNA biosynthetic processGO:200057310.9PDGFRB, PDGFB
17positive regulation of calcium ion importGO:09028010.9PDGFB, PDGFRB
18positive regulation of chemotaxisGO:05092110.9PDGFB, PDGFRB
19response to drugGO:04249310.8PDGFB, MGMT, MDM2, CDK4
20regulation of peptidyl-tyrosine phosphorylationGO:05073010.8PDGFRB, EGFR
21positive regulation of smooth muscle cell migrationGO:01491110.7PDGFB, PDGFRB
22response to hyperoxiaGO:05509310.7CDK4, PDGFRB
23positive regulation of ERK1 and ERK2 cascadeGO:07037410.5EGFR, PDGFRB, PDGFB

Molecular functions related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.7PDGFRB, PDGFB
2platelet-derived growth factor receptor bindingGO:00516110.5FIGF, PDGFRB, PDGFB

Products for genes affiliated with Glioblastoma Multiforme

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glioblastoma Multiforme

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet