GBM
MCID: GLB015
MIFTS: 59

Glioblastoma Multiforme (GBM) malady

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Summaries for Glioblastoma Multiforme

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derived from multiple cell types including astrocytes and oligondroctyes.

MalaCards: Glioblastoma Multiforme, also known as glioblastoma, is related to anaplastic astrocytoma and astrocytoma. An important gene associated with Glioblastoma Multiforme is TRRAP (transformation/transcription domain-associated protein), and among its related pathways are Validated targets of C-MYC transcriptional activation and Spinal Cord Injury. The compounds methylglyoxal and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone, and related mouse phenotypes are embryogenesis and tumorigenesis.

Wikipedia:65 Glioblastoma multiforme (GBM), WHO classification name \"glioblastoma\", is the most common and most... more...

Aliases & Classifications for Glioblastoma Multiforme

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 35MeSH, 40NCIt, 58SNOMED-CT, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

glioblastoma multiforme 8 43 45
glioblastoma 8 43 10 45
adult glioblastoma multiforme 8 10
grade iv adult astrocytic tumor 8
primary glioblastoma multiforme 8
spongioblastoma multiforme 8
giant cell glioblastoma 43
glioblastoma nos 8
gliosarcoma 43
gbm 8


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Disease Ontology8 DOID:3068
MeSH35 D005909
NCIt40 C3058, C9094

Related Diseases for Glioblastoma Multiforme

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17GeneCards, 18GeneDecks
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Diseases related to Glioblastoma Multiforme via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic astrocytoma31.3GFAP, NES, CDK4, EGFR
2astrocytoma31.3GFAP, HSPB2, NES, ANGPT2, IL13RA2, CDK4
3gliosarcoma30.9CDK4, GFAP
4giant cell glioblastoma30.6EGFR, GFAP
5brain cancer30.6GFAP, NES, EGFR
6malignant glioma30.6GFAP, NES, ANGPT2, IL13RA2, CDK4, EGFR
7ganglioglioma30.6GFAP
8pilocytic astrocytoma30.5GFAP, NES, CDK4
9medulloblastoma30.5CDK4, IL13RA2, NES, GFAP
10breast cancer30.4CDK6, CDK4, EGFR
11sarcoma30.4CDK4, CDK6, ANGPT2, NES
12adenoma30.3NES, FIGF, ANGPT2, FOSL1, CDK4
13oligodendroglioma30.3GFAP, EGFR
14hemangioblastoma30.3NES, GFAP
15retinoblastoma30.3GFAP, CDK6, CDK4, EGFR, TRRAP
16leukemia30.2CYP27B1, FLT3LG, NES, ANGPT2, CDK6, CDK4
17melanoma30.2CYP27B1, HSPB2, FLT3LG, NES, FIGF, ANGPT2
18adenocarcinoma30.1CYP27B1, CLDN5, NES, FIGF, ANGPT2, FOSL1
19anaplastic oligodendroglioma30.0GFAP, CDK4, EGFR
20lung cancer30.0EGFR, CDK4, FOSL1, ANGPT2, FIGF
21colon cancer30.0CYP27B1, FOSL1, CDK6, CDK4, EGFR
22gemistocytic astrocytoma29.9GFAP
23prostate cancer29.9CYP27B1, HSPB2, NES, FIGF, ANGPT2, IL13RA2
24subependymal giant cell astrocytoma29.9GFAP
25t-cell leukemia29.9FOSL1, CDK6, CDK4
26brain edema29.9GFAP, CLDN5
27ependymoma29.8GFAP, NES, EGFR
28ovarian cancer29.7HSPB2, FIGF, CDK4, EGFR
29colorectal cancer29.7EGFR, CDK4, ANGPT2, FIGF
30pancreatic cancer29.7NES, CDK6, CDK4, EGFR
31brain glioblastoma multiforme10.7
32endotheliitis10.6
33glomerulonephritis10.6
34hypoxia10.6
35cerebritis10.6
36meningioma10.5
37adult spinal cord glioblastoma multiforme10.4
38gliomatosis cerebri10.4
39pleomorphic xanthoastrocytoma10.4
40turcot syndrome10.4
41cytomegalovirus infection10.4
42goodpasture syndrome10.3
43crescentic glomerulonephritis10.3
44rapidly progressive glomerulonephritis10.3
45transitional meningioma10.3
46acoustic neuroma10.3
47muir-torre syndrome10.3
48aplastic anemia10.3
49communicating hydrocephalus10.3
50encephalomyelitis10.3

Graphical network of the top 20 diseases related to Glioblastoma Multiforme:



Diseases related to glioblastoma multiforme

Symptoms for Glioblastoma Multiforme

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Drugs & Therapeutics for Glioblastoma Multiforme

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Glioblastoma Multiforme

Search NIH Clinical Center for Glioblastoma Multiforme

Genetic Tests for Glioblastoma Multiforme

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Anatomical Context for Glioblastoma Multiforme

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33MalaCards
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MalaCards organs/tissues related to Glioblastoma Multiforme:

33
Brain, Endothelial, Bone, Spinal cord, Lung, Breast, Prostate, Temporal lobe, T cells, Thyroid, Liver, Colon, Pituitary

Animal Models for Glioblastoma Multiforme or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Glioblastoma Multiforme:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.4TRRAP, EGFR, CDK4, CDK6, FOSL1, NES
2MP:00020068.0FIGF, GLIPR1, CDK6, CDK4, EGFR
3MP:00053847.7CYP27B1, GFAP, HSPB2, NES, GLIPR1, CDK6
4MP:00053977.4CYP27B1, TNFSF13, FLT3LG, FOSL1, IL13RA2, CDK6
5MP:00053787.3CYP27B1, GFAP, HSPB2, NES, FIGF, FOSL1
6MP:00053857.2GFAP, HSPB2, CLDN5, FIGF, ANGPT2, FOSL1
7MP:00107686.6NES, CLDN5, HSPB2, GFAP, EBF3, FIGF
8MP:00053876.3EGFR, CYP27B1, GFAP, TNFRSF12A, TNFSF13, HSPB2

Publications for Glioblastoma Multiforme

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52PubMed
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Articles related to Glioblastoma Multiforme:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Illuminating Radiogenomic Characteristics of Glioblastoma Multiforme through Integration of MR Imaging, Messenger RNA Expression, and DNA Copy Number Variation. (24056404)
2014
2
Case Report: Glioblastoma Multiforme Complicating Familial Cavernous Malformations. (23942770)
2013
3
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. (23871826)
2013
4
Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival. (23391370)
2013
5
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. (23940299)
2013
6
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
7
Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis. (22972189)
2012
8
TLR9 expression is associated with prognosis in patients with glioblastoma multiforme. (22169598)
2012
9
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
10
In situ analysis of mutant EGFRs prevalent in glioblastoma multiforme reveals aberrant dimerization, activation, and differential response to anti-EGFR targeted therapy. (22232519)
2012
11
Deciphering the signaling pathways of cancer stem cells of glioblastoma multiforme: role of Akt/mTOR and MAPK pathways. (21035497)
2011
12
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. (19784869)
2010
13
Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme: a report of 7 cases. (19747042)
2010
14
Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. (19655089)
2010
15
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. (18701427)
2009
16
Paradoxical expression of anti-apoptotic and MRP genes on cancer stem-like cell isolated from TJ905 glioblastoma multiforme cell line. (18443953)
2008
17
Bevacizumab and irinotecan therapy in glioblastoma multiforme: a series of 13 cases. (18671639)
2008
18
Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy. (18352856)
2008
19
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. (19074898)
2008
20
Long-term survival with glioblastoma multiforme. (17785346)
2007
21
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. (17048097)
2007
22
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. (17947719)
2007
23
Nestin expression in the cell lines derived from glioblastoma multiforme. (16457706)
2006
24
Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer. (16958968)
2006
25
Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme. (16709029)
2006
26
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. (17111679)
2006
27
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol. (16709245)
2006
28
Activation patterns of epidermal growth factor-receptor signaling in glioblastoma multiforme: in regard to Chakravarti et al. (Int J Radiat Oncol Biol Phys 2005;62:318-327). (15990031)
2005
29
mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. (16199861)
2005
30
Chromogenic in situ hybridization accurately identifies EGFR amplification in small cell glioblastoma multiforme, a common subtype of primary GBM. (16033132)
2005
31
Fascin expression in 90 patients with glioblastoma multiforme. (16308158)
2005
32
PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. (16007122)
2005
33
A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease. (14973082)
2004
34
Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme. (12507885)
2003
35
Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression? (12899520)
2003
36
O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme. (12684420)
2003
37
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. (12466961)
2002
38
Association of elevated glial expression of interleukin-1beta with improved survival in patients with glioblastomas multiforme. (11838804)
2002
39
Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. (12376778)
2002
40
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (11995970)
2001
41
Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme? (11706939)
2001
42
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
43
Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. (10663630)
2000
44
Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy. (10730637)
2000
45
Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. (9679546)
1998
46
Somatic mutations of PTEN in glioblastoma multiforme. (9331071)
1997
47
Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study. (7557949)
1995
48
Concentration of elements in human brain: glioblastoma multiforme. (8272844)
1993
49
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
50
Effect of recombinant fibroblast interferon and recombinant immune interferon on growth and the antigenic phenotype of multidrug-resistant human glioblastoma multiforme cells. (1653364)
1991

Variations for Glioblastoma Multiforme

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Expression for genes affiliated with Glioblastoma Multiforme

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glioblastoma Multiforme

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Pathways for genes affiliated with Glioblastoma Multiforme

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG
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Pathways related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FOSL1, CDK4, TRRAP
29.6GFAP, TNFSF13, CDK4, EGFR
39.4CDK4, CDK6
4
Show member pathways
Signaling Pathways in Glioblastoma38
9.2EGFR, CDK4, CDK6
5
Show member pathways
9.2CDK6, CDK4, EGFR
69.2EGFR, CDK4, CDK6
7
Show member pathways
8.6TNFRSF12A, TNFSF13, FIGF, ANGPT2, IL13RA2, EGFR
88.5EGFR, CDK4, CDK6, ANGPT2, FIGF
9
Show member pathways
8.2TNFRSF12A, TNFSF13, FIGF, ANGPT2, FOSL1, IL13RA2
108.0FLT3LG, FIGF, CDK6, CDK4, EGFR
11
Show member pathways
8.0TNFRSF12A, TNFSF13, FLT3LG, FIGF, ANGPT2, IL13RA2
12
Show member pathways
6.9EGFR, GFAP, TNFRSF12A, TNFSF13, FIGF, ANGPT2

Compounds for genes affiliated with Glioblastoma Multiforme

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29IUPHAR, 45Novoseek, 11DrugBank, 61Tocris Bioscience, 3BitterDB, 24HMDB, 51PharmGKB
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Compounds related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1methylglyoxal29 4511.2HSPB2, ANGPT2
2temozolomide45 1111.1NES, EGFR
3lead4510.1CDK4, GFAP, CYP27B1
4bromodeoxyuridine4510.0CDK4, NES, GFAP
5fisetin459.8CDK6, CDK4
6genistein45 29 61 3 24 1114.8EGFR, CDK4, GFAP, CYP27B1
7su 9516619.8CDK6, CDK4
8matrigel459.8GFAP, NES, ANGPT2, FOSL1
9purvalanol b619.8CDK6, CDK4
10ro 3306619.8CDK6, CDK4
11kenpaullone45 6110.8CDK6, CDK4
12quercetin45 61 24 1112.7CDK4, HSPB2, GFAP
13retinoid459.7EGFR, CDK4, FOSL1, CYP27B1
14bcnu459.7GFAP, EGFR
15berberine459.7CDK4, CDK6
16purvalanol a61 45 1111.7CDK4, CDK6
17eb 108945 6110.6CDK4, CDK6, CYP27B1
18paraffin459.6CYP27B1, GFAP, NES, ANGPT2, CDK4, EGFR
19silymarin459.6CDK6, CDK4, EGFR
20flavopiridol45 1110.6CDK6, CDK4, EGFR
21cycloheximide459.6EGFR, CDK4, GFAP, CYP27B1
22gefitinib45 51 1111.5CDK6, CDK4, EGFR
23sb 20358045 6110.5EGFR, CDK4, FOSL1, HSPB2
241,25 dihydroxy vitamin d3459.5CYP27B1, CDK6, CDK4
25apigenin45 2910.5CDK4, CDK6
2617-(allylamino)-17-demethoxygeldanamycin459.4CDK4, CDK6, HSPB2
27trastuzumab45 51 1111.4ANGPT2, CDK6, CDK4, EGFR
28progesterone45 29 61 24 1113.4GFAP, NES, FIGF, CDK4, EGFR
29progestin459.4EGFR, CDK4, CDK6, ANGPT2
30glucose459.4CYP27B1, GFAP, HSPB2, NES, ANGPT2, CDK4
31egcg459.4CDK6, CDK4, EGFR
32pd 98,059459.4GFAP, HSPB2, FOSL1, CDK4, EGFR
33herbimycin a45 6110.3CDK6, CDK4, EGFR
34ly294002459.3ANGPT2, CDK6, CDK4, EGFR
35cyclic amp45 2410.2CDK4, FOSL1, GFAP, CYP27B1
36nitric oxide45 24 1111.1NES, FIGF, ANGPT2, FOSL1, CDK4
37cisplatin45 51 61 1112.0GFAP, HSPB2, CDK6, CDK4, EGFR
38thymidine45 249.8CDK4, CDK6, ANGPT2, FLT3LG, GFAP
39retinoic acid45 249.3CYP27B1, GFAP, NES, ANGPT2, FOSL1, CDK6
40vegf458.3GFAP, HSPB2, FLT3LG, NES, FIGF, ANGPT2
41serine458.3GFAP, HSPB2, ANGPT2, FOSL1, CDK6, CDK4
42oxygen45 249.1CYP27B1, GFAP, HSPB2, NES, FIGF, ANGPT2
43calcium45 51 24 1111.0CYP27B1, GFAP, HSPB2, CLDN5, ANGPT2, FOSL1
44estrogen457.8CYP27B1, GFAP, NES, FIGF, ANGPT2, FOSL1
45tyrosine456.8EGFR, CYP27B1, GFAP, HSPB2, FLT3LG, NES

GO Terms for genes affiliated with Glioblastoma Multiforme

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16Gene Ontology
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Cellular components related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.4CDK4, CDK6
2extracellular spaceGO:0056158.1EGFR, IL13RA2, ANGPT2, FIGF, FLT3LG, TNFSF13

Biological processes related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1astrocyte developmentGO:0140029.4CDK6, GFAP
2positive regulation of fibroblast proliferationGO:0481469.1CDK6, CDK4, EGFR
3signal transductionGO:0071658.4EGFR, CDK4, IL13RA2, ANGPT2, FLT3LG, TNFSF13
4positive regulation of cell proliferationGO:0082848.2EGFR, CDK4, FOSL1, FIGF, FLT3LG, TNFSF13

Molecular functions related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:0309719.7ANGPT2, FLT3LG
2cyclin bindingGO:0303329.1CDK4, CDK6

Products for genes affiliated with Glioblastoma Multiforme

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Sources for Glioblastoma Multiforme

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet