GBM
MCID: GLB015
MIFTS: 64

Glioblastoma Multiforme (GBM) malady

Cancer diseases category

Summaries for Glioblastoma Multiforme

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derived from multiple cell types including astrocytes and oligondroctyes.

MalaCards: Glioblastoma Multiforme, also known as glioblastoma, is related to astrocytoma and meningioma. An important gene associated with Glioblastoma Multiforme is TRRAP (transformation/transcription domain-associated protein), and among its related pathways are Pathways in cancer and Rho Family GTPases. The compounds vegf and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone, and related mouse phenotypes are mortality/aging and immune system.

Wikipedia:63 Glioblastoma multiforme (GBM), WHO classification name \"glioblastoma\", is the most common and most... more...

Aliases & Classifications for Glioblastoma Multiforme

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42NIH Rare Diseases, 8Disease Ontology, 44Novoseek, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

glioblastoma multiforme 8 42 44
glioblastoma 8 42 10 44
adult glioblastoma multiforme 8 10
grade iv adult astrocytic tumor 8
primary glioblastoma multiforme 8
spongioblastoma multiforme 8
giant cell glioblastoma 42
glioblastoma nos 8
gliosarcoma 42
gbm 8


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Disease Ontology8 DOID:3068
NCIt39 C9094, C3058
MeSH34 D005909

Related Diseases for Glioblastoma Multiforme

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17GeneCards, 18GeneDecks
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Diseases related to Glioblastoma Multiforme via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.3HSPB2, PDGFB, IL13RA2, CDK4, HIF1A, NES
2meningioma30.7PDGFRB, PDGFB
3gliosarcoma30.7CDK4, PDGFRB
4malignant glioma30.7PDGFB, PDGFRB, E2F1, IL13RA2, CDK4, HIF1A
5melanoma30.5MGMT, E2F1, PDGFRB, PDGFB, HLA-B, MDM2
6brain cancer30.5EGFR, MDM2, MGMT
7giant cell glioblastoma30.5EGFR, MDM2
8adenocarcinoma30.4MDM2, HLA-B, MGMT, E2F1, PDGFRB, PDGFB
9breast cancer30.4HSPB2, E2F1, HLA-B, MDM2, PIK3CA, EGFR
10leukemia30.4PDGFB, PDGFRB, E2F1, MGMT, HLA-B, MDM2
11medulloblastoma30.3PDGFB, E2F1, MGMT, PIK3CA, NES, CDK4
12sarcoma30.3PDGFB, PDGFRB, E2F1, MDM2, NES, CDK4
13adenoma30.3E2F1, MGMT, HLA-B, NES, FIGF, CDK4
14meningitis30.3HLA-B
15retinoblastoma30.3CDK4, TRRAP, EGFR, PIK3CA, MDM2, E2F1
16lung adenocarcinoma30.1PDGFRB, E2F1, MGMT, PIK3CA, EGFR, FIGF
17pituitary adenoma30.1E2F1, MGMT, NES, CDK4
18leiomyosarcoma30.1CDK4, NES, MDM2, PDGFRB
19lung small cell carcinoma30.1E2F1, MGMT, PIK3CA, EGFR
20ataxia telangiectasia30.1E2F1, MDM2, PIK3CA
21acute leukemia30.1E2F1, PIK3CA
22hemangioblastoma30.1HIF1A, NES
23prostate cancer30.1E2F1, EGFR, HIF1A, CDK4
24thyroid cancer30.1PIK3CA
25malignant mesothelioma30.1CDK4, PDGFRB
26oligodendroglioma30.1EGFR, MGMT
27herpes simplex30.1HLA-B
28alzheimer's disease30.1HSPB2
29osteosarcoma30.1PDGFB, PDGFRB, E2F1, MDM2, HIF1A, CDK4
30colon cancer30.0PDGFRB, E2F1, MGMT, MDM2, PIK3CA, EGFR
31lung cancer30.0EGFR, PIK3CA
32hepatocellular carcinoma29.9PDGFB, E2F1, MGMT, MDM2, PIK3CA, HIF1A
33myeloid leukemia29.9E2F1, CDK4
34squamous cell carcinoma29.8CLDN5, HSPB2, PDGFB, E2F1, MGMT, HLA-B
35rhabdomyosarcoma29.8PDGFB, PDGFRB, MDM2, NES, CDK4
36pancreatic cancer29.8PDGFRB, MGMT, EGFR, NES
37chondrosarcoma29.8CDK4, MDM2, E2F1, PDGFRB
38brain glioma29.8CLDN5
39ovarian cancer29.7HSPB2, PDGFRB, E2F1, MDM2, PIK3CA, EGFR
40colorectal cancer29.7PDGFRB, E2F1, MGMT, MDM2, PIK3CA, EGFR
41fibrosarcoma29.7PDGFRB, E2F1, MDM2, NES, HIF1A
42cholangiocarcinoma29.7PIK3CA
43brain glioblastoma multiforme10.9
44glomerulonephritis10.6
45cerebritis10.5
46adult spinal cord glioblastoma multiforme10.4
47ganglioglioma10.3
48gliomatosis cerebri10.3
49pleomorphic xanthoastrocytoma10.3
50crescentic glomerulonephritis10.3

Graphical network of the top 20 diseases related to Glioblastoma Multiforme:



Diseases related to glioblastoma multiforme

Clinical Features for Glioblastoma Multiforme

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Drugs & Therapeutics for Glioblastoma Multiforme

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Glioblastoma Multiforme

Search NIH Clinical Center for Glioblastoma Multiforme

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Genetic Tests for Glioblastoma Multiforme

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Anatomical Context for Glioblastoma Multiforme

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32MalaCards
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MalaCards organs/tissues related to Glioblastoma Multiforme:

32
Brain, Endothelial, Bone, Spinal cord, Lung, Breast, Prostate, Temporal lobe, T cells, Thyroid, Liver, Colon, Pituitary

Animal Models for Glioblastoma Multiforme or affiliated genes

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36MGI
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Publications for Glioblastoma Multiforme

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50PubMed
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Articles related to Glioblastoma Multiforme:

(show top 50)    (show all 569)
idTitleAuthorsYear
1
The Identification of Mitochondrial DNA Variants in Glioblastoma Multiforme. (24383468)
2014
2
MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated. (24211747)
2014
3
The Neutrophil Lymphocyte Ratio in Patients with Glioblastoma Multiforme. (24407734)
2014
4
Glioblastoma Multiforme Metastastic to the Bone: Diagnosis by 18F-NaF PET/CT. (24300358)
2014
5
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. (23871826)
2013
6
Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme. (24100685)
2013
7
Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform. (24322672)
2013
8
An extremely rare case of glioblastoma multiforme of the spinal cord. (24247921)
2013
9
Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor. (23977270)
2013
10
Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. (23928381)
2013
11
Prospective study evaluating the radiosensitizing effect of reduced doses of temozolomide in the treatment of Egyptian patients with glioblastoma multiforme. (24133376)
2013
12
Glioblastoma Multiforme Arising From Dysembryoplastic Neuroepithelial Tumor in a Child in the Absence of Therapy. (24309599)
2013
13
'Goose bumps' as presenting feature of intraventricular glioblastoma multiforme. (23883371)
2013
14
TLR9 expression is associated with prognosis in patients with glioblastoma multiforme. (22169598)
2012
15
PARP-1 protein expression in glioblastoma multiforme. (22472897)
2012
16
MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. (23034333)
2012
17
Integration of global spectral karyotyping, CGH arrays, and expression arrays reveals important genes in the pathogenesis of glioblastoma multiforme. (22395973)
2012
18
Immunohistochemical assessment of MGMT expression and p53 mutation in glioblastoma multiforme. (21528672)
2011
19
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme. (21726646)
2011
20
Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. (20354191)
2010
21
Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme. (19768386)
2010
22
Gliosarcoma: a rare variant of glioblastoma multiforme. (21381591)
2010
23
Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme. (19672263)
2009
24
Immunohistopathological and neuroimaging characterization of murine orthotopic xenograft models of glioblastoma multiforme recapitulating the most salient features of human disease. (19475534)
2009
25
The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme. (18991494)
2009
26
Aquaporin-4 contributes to the resolution of peritumoural brain oedema in human glioblastoma multiforme after combined chemotherapy and radiotherapy. (19836227)
2009
27
The effects of tibolone on the human primary glioblastoma multiforme cell culture and the rat C6 glioma model. (19531283)
2009
28
Glioblastoma multiforme cells: expression of erythropoietin receptor and response to erythropoietin. (17912447)
2007
29
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol. (16709245)
2006
30
The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia. (16217754)
2006
31
Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. (16609006)
2006
32
Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors. (16540738)
2006
33
Activation patterns of epidermal growth factor-receptor signaling in glioblastoma multiforme: in regard to Chakravarti et al. (Int J Radiat Oncol Biol Phys 2005;62:318-327). (15990031)
2005
34
Fascin expression in 90 patients with glioblastoma multiforme. (16308158)
2005
35
Extra-cranial metastasis of glioblastoma multiforme presenting as acute parotitis. (16455543)
2005
36
Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. (15720813)
2005
37
A Phase II trial of paclitaxel and topotecan with filgrastim in patients with recurrent or refractory glioblastoma multiforme or anaplastic astrocytoma. (15735921)
2005
38
EphA2 as a novel molecular marker and target in glioblastoma multiforme. (16254188)
2005
39
Association of chromosome 7, chromosome 10 and EGFR gene amplification in glioblastoma multiforme. (16167544)
2005
40
Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes. (14965379)
2004
41
Prognostic significance of annexin VII expression in glioblastomas multiforme in humans. (14609169)
2003
42
The conditional probabilities of survival in patients with anaplastic astrocytoma or glioblastoma multiforme. (14572960)
2003
43
Association of elevated glial expression of interleukin-1beta with improved survival in patients with glioblastomas multiforme. (11838804)
2002
44
Antisense anti-MDM2 oligonucleotides as a novel approach to the treatment of glioblastoma multiforme. (12017271)
2002
45
Distribution of epidermal growth factor receptor protein correlates with gain in chromosome 7 revealed by comparative genomic hybridization after microdissection in glioblastoma multiforme. (11432670)
2001
46
TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme. (11519857)
2001
47
Reactivation of human neurotropic JC virus expressing oncogenic protein in a recurrent glioblastoma multiforme. (11117551)
2000
48
Comparative genetic patterns of glioblastoma multiforme: potential diagnostic tool for tumor classification. (11302337)
2000
49
Subsets of glioblastoma multiforme defined by molecular genetic analysis. (8269081)
1993
50
An autoradiographic study of human gliomas: growth kinetics of anaplastic astrocytoma and glioblastoma multiforme. (6254610)
1980

Genetic Variations for Glioblastoma Multiforme

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Expression for genes affiliated with Glioblastoma Multiforme

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glioblastoma Multiforme

Search GEO for disease gene expression data for Glioblastoma Multiforme.

Pathways for genes affiliated with Glioblastoma Multiforme

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Sources:
29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 52R&D Systems, 59Tocris Bioscience, 55SinoBiological, 49PharmGKB
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Pathways related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.5PDGFB, PDGFRB, E2F1, MDM2, PIK3CA, EGFR
2
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11.5PDGFB, PDGFRB, E2F1, MDM2, EGFR, FIGF
311.3PDGFB, PDGFRB, E2F1, HLA-B, PIK3CA, TRRAP
411.3PDGFB, PDGFRB, MDM2, PIK3CA, EGFR, FIGF
511.3CDK4, PDGFB, PDGFRB, E2F1, MGMT, MDM2
611.2PDGFB, PDGFRB, MDM2, PIK3CA, EGFR, HIF1A
7
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11.2PDGFB, PDGFRB, HLA-B, MDM2, PIK3CA, EGFR
8
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11.2PDGFB, PDGFRB, HLA-B, MDM2, PIK3CA, EGFR
911.2PDGFB, PDGFRB, E2F1, MDM2, PIK3CA, EGFR
10
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11.2IL13RA2, FIGF, EGFR, MDM2, PDGFRB, PDGFB
11
Hide members
11.1PDGFB, PDGFRB, PIK3CA, EGFR, HIF1A
12
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11.1EGFR, PIK3CA, MDM2, PDGFRB, PDGFB
13
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11.1PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
14
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11.1PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
1511.1HSPB2, MDM2, PIK3CA, EGFR, HIF1A
16
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11.1E2F1, MDM2, PIK3CA, EGFR, CDK4
1711.1E2F1, MDM2, PIK3CA, EGFR, CDK4
18
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11.1E2F1, MGMT, MDM2, TRRAP, CDK4
19
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11.1PDGFB, PDGFRB, PIK3CA, EGFR, FIGF
2011.1PDGFRB, E2F1, MDM2, EGFR, CDK4
21
Hide members
11.1PDGFB, PDGFRB, MDM2, EGFR, FIGF
2210.9HLA-B, MDM2, PIK3CA, CDK4
23
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10.9EGFR, PIK3CA, MDM2, PDGFRB
2410.9HIF1A, PIK3CA, PDGFRB, PDGFB
25
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10.9EGFR, PIK3CA, PDGFRB, PDGFB
2610.9PIK3CA, MDM2, HLA-B, HSPB2
27
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10.9CDK4, PIK3CA, MDM2, E2F1
28
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10.9E2F1, MDM2, HIF1A, CDK4
2910.9E2F1, MDM2, EGFR, CDK4
30
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10.9CDK4, MDM2, MGMT, E2F1
31
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10.9EGFR, PDGFRB, PDGFB, HSPB2
32
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10.9PDGFB, PDGFRB, E2F1, MDM2
33
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10.9CDK4, FIGF, E2F1, PDGFB
34
Transcription Androgen Receptor nuclear signaling
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10.8EGFR, PIK3CA, MDM2
3510.8PDGFB, PIK3CA, HIF1A
36
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10.8PDGFRB, PIK3CA, EGFR
3710.8EGFR, PIK3CA, PDGFRB
3810.8PDGFRB, PIK3CA, EGFR
39
G-protein signaling H-RAS regulation pathway
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10.8PDGFB, PDGFRB, PIK3CA
40
Cytoskeleton remodeling Role of PDGFs in cell migration
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10.8PDGFB, PDGFRB, PIK3CA
41
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10.8FIGF, EGFR, PIK3CA
42
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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10.8E2F1, EGFR, HIF1A
4310.8E2F1, PIK3CA, CDK4
4410.8E2F1, PIK3CA, CDK4
4510.8HIF1A, FIGF, MDM2
46
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10.8E2F1, MDM2, CDK4
47
Transcription P53 signaling pathway
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10.8E2F1, MDM2, CDK4
48
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10.8PDGFB, FIGF, IL13RA2
49
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10.7PDGFB, PDGFRB
5010.7PDGFRB, PDGFB

Compounds for genes affiliated with Glioblastoma Multiforme

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1vegf4412.3MGMT, NES, EGFR, PIK3CA, MDM2, E2F1
2tyrosine4412.3NES, CDK4, MDM2, HIF1A, HLA-B, FIGF
3progesterone44 59 28 11 2416.1FIGF, NES, EGFR, PIK3CA, MGMT, E2F1
4oligonucleotide4412.1MDM2, PDGFB, CLDN5, CDK4, HIF1A, HLA-B
5nitric oxide44 11 2414.1PDGFB, MGMT, E2F1, HLA-B, MDM2, PIK3CA
6serine4412.0EGFR, PIK3CA, CDK4, MDM2, HLA-B, E2F1
7paraffin4412.0HIF1A, CDK4, NES, EGFR, MDM2, HLA-B
8cisplatin44 49 59 1115.0HSPB2, PDGFRB, E2F1, HIF1A, CDK4, EGFR
9retinoic acid44 2412.9E2F1, PDGFRB, EGFR, MGMT, NES, HLA-B
105fluorouracil4411.9PIK3CA, MDM2, MGMT, E2F1, CDK4, PDGFRB
11agar4411.9PDGFB, PIK3CA, PDGFRB, E2F1, CDK4, HIF1A
12doxorubicin44 49 1113.8PIK3CA, EGFR, HIF1A, CDK4, MGMT, E2F1
13testosterone44 59 11 2414.8CDK4, PIK3CA, HIF1A, HLA-B, E2F1, PDGFRB
14paclitaxel44 49 1113.7HIF1A, CDK4, EGFR, PIK3CA, E2F1, PDGFRB
15rapamycin4411.7MDM2, CDK4, HIF1A, PDGFRB, E2F1, EGFR
16pd 98,0594411.7CDK4, HIF1A, PDGFB, EGFR, HSPB2, MDM2
17genistein44 28 59 2 11 2416.7PIK3CA, CDK4, HIF1A, MDM2, MGMT, PDGFRB
18thymidine44 2412.7PDGFB, PIK3CA, MDM2, MGMT, E2F1, HIF1A
19flavopiridol44 1112.6E2F1, CDK4, PDGFRB, HIF1A, EGFR, MDM2
20oxygen44 2412.6E2F1, NES, MDM2, FIGF, CDK4, HSPB2
21bromodeoxyuridine4411.6CDK4, PIK3CA, PDGFRB, E2F1, PDGFB, NES
22phosphotyrosine4411.6CDK4, PIK3CA, PDGFRB, EGFR, PDGFB, HLA-B
23phosphatidylinositol4411.5PDGFRB, PIK3CA, CDK4, HIF1A, EGFR, MDM2
24ly2940024411.5HIF1A, MDM2, EGFR, PIK3CA, CDK4, PDGFRB
25proline4411.5MDM2, PDGFRB, MGMT, HLA-B, HIF1A, CDK4
26trastuzumab44 49 1113.5MDM2, PIK3CA, EGFR, HIF1A, CDK4
27carboplatin44 49 1113.5MGMT, MDM2, EGFR, HIF1A, CDK4
28gefitinib44 49 1113.5EGFR, MDM2, CDK4, PDGFRB, PIK3CA
29dexamethasone44 49 28 1114.5PIK3CA, PDGFB, MGMT, MDM2, HIF1A, CDK4
30thymidylate4411.4MGMT, CDK4, E2F1, MDM2, EGFR
31docetaxel44 49 59 1114.4HIF1A, EGFR, PIK3CA, MDM2, PDGFRB
32camptothecin44 59 1113.4MDM2, HIF1A, E2F1, CDK4, MGMT
33imatinib44 49 1113.4EGFR, PIK3CA, PDGFRB, MDM2, PDGFB
34tacrolimus44 49 1113.4HLA-B, PDGFB, PIK3CA, HIF1A, CDK4
35glucose4411.3HIF1A, PDGFRB, PIK3CA, MGMT
36vincristine44 49 1113.3HIF1A, HSPB2, E2F1, MGMT
37topotecan44 1112.3PDGFRB, HIF1A, EGFR, MGMT
38irinotecan44 49 1113.2MDM2, HIF1A, EGFR, MGMT
39adpribose4411.2CDK4, EGFR, PIK3CA, MDM2
40h2o24411.2PIK3CA, MDM2, PDGFRB, HSPB2, HLA-B, HIF1A
41gemcitabine44 49 1113.1EGFR, E2F1, PDGFRB, HIF1A
42geldanamycin44 49 59 1114.1MDM2, EGFR, CDK4, HIF1A
43su54164411.1HIF1A, EGFR, PDGFRB
44lactacystin4411.1E2F1, MDM2, HIF1A, CDK4
45tamoxifen44 49 28 1114.1HIF1A, PIK3CA, EGFR, FIGF, E2F1
46temozolomide44 1111.9EGFR, NES, MGMT
47etoposide44 49 59 1113.9MDM2, HIF1A
48sunitinib44 49 1112.9HIF1A, EGFR, PDGFRB
49noxa4410.5E2F1, MDM2, HIF1A
50cycloheximide4410.5PDGFB

GO Terms for genes affiliated with Glioblastoma Multiforme

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16Gene Ontology
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Biological processes related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell proliferationGO:00828411.5CDK4, FIGF, EGFR, MDM2, PDGFRB, PDGFB
2innate immune responseGO:04508711.4PDGFB, PDGFRB, HLA-B, MDM2, PIK3CA, EGFR
3phosphatidylinositol-mediated signalingGO:04801511.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
4fibroblast growth factor receptor signaling pathwayGO:00854311.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
5Fc-epsilon receptor signaling pathwayGO:03809511.4EGFR, PIK3CA, MDM2, PDGFRB, PDGFB
6epidermal growth factor receptor signaling pathwayGO:00717311.4PDGFB, PDGFRB, MDM2, PIK3CA, EGFR
7neurotrophin TRK receptor signaling pathwayGO:04801111.4EGFR, PIK3CA, MDM2, PDGFRB, PDGFB
8positive regulation of fibroblast proliferationGO:04814611.3CDK4, EGFR, E2F1, PDGFB
9embryonic placenta developmentGO:00189211.1PDGFB, EGFR, HIF1A
10positive regulation of MAP kinase activityGO:04340611.1PDGFB, PDGFRB, EGFR
11response to toxic substanceGO:00963611.0PDGFRB, MGMT, CDK4
12metanephric glomerular mesangial cell proliferation involved in metanephros developmentGO:07226211.0PDGFB, PDGFRB
13positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayGO:03579311.0PDGFRB, PDGFB
14retina vasculature development in camera-type eyeGO:06129811.0HIF1A, PDGFRB
15cellular response to hypoxiaGO:07145610.9HIF1A, MDM2, E2F1
16positive regulation of DNA biosynthetic processGO:200057310.9PDGFRB, PDGFB
17positive regulation of calcium ion importGO:09028010.9PDGFB, PDGFRB
18positive regulation of chemotaxisGO:05092110.9PDGFB, PDGFRB
19response to drugGO:04249310.8PDGFB, MGMT, MDM2, CDK4
20regulation of peptidyl-tyrosine phosphorylationGO:05073010.8PDGFRB, EGFR
21positive regulation of smooth muscle cell migrationGO:01491110.7PDGFB, PDGFRB
22response to hyperoxiaGO:05509310.7CDK4, PDGFRB
23positive regulation of ERK1 and ERK2 cascadeGO:07037410.5EGFR, PDGFRB, PDGFB

Molecular functions related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.7PDGFRB, PDGFB
2platelet-derived growth factor receptor bindingGO:00516110.5FIGF, PDGFRB, PDGFB

Products for genes affiliated with Glioblastoma Multiforme

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet