GBM
MCID: GLB015
MIFTS: 59

Glioblastoma Multiforme (GBM) malady

Rare diseases, Cancer diseases categories

Summaries for Glioblastoma Multiforme

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derived from multiple cell types including astrocytes and oligondroctyes.

MalaCards: Glioblastoma Multiforme, also known as glioblastoma, is related to anaplastic astrocytoma and astrocytoma. An important gene associated with Glioblastoma Multiforme is TRRAP (transformation/transcription domain-associated protein), and among its related pathways are Validated targets of C-MYC transcriptional activation and Spinal Cord Injury. The compounds methylglyoxal and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone, and related mouse phenotypes are embryogenesis and tumorigenesis.

Wikipedia:66 Glioblastoma multiforme (GBM), WHO classification name \"glioblastoma\", is the most common and most... more...

Aliases & Classifications for Glioblastoma Multiforme

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 36MeSH, 41NCIt, 59SNOMED-CT, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

glioblastoma multiforme 9 44 46
glioblastoma 9 44 11 46
adult glioblastoma multiforme 9 11
grade iv adult astrocytic tumor 9
primary glioblastoma multiforme 9
spongioblastoma multiforme 9
giant cell glioblastoma 44
glioblastoma nos 9
gliosarcoma 44
gbm 9


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Disease Ontology9 DOID:3068
MeSH36 D005909
NCIt41 C3058, C9094

Related Diseases for Glioblastoma Multiforme

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18GeneCards, 19GeneDecks
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Diseases related to Glioblastoma Multiforme via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic astrocytoma31.3GFAP, NES, CDK4, EGFR
2astrocytoma31.3GFAP, HSPB2, NES, ANGPT2, IL13RA2, CDK4
3gliosarcoma30.9CDK4, GFAP
4giant cell glioblastoma30.6EGFR, GFAP
5brain cancer30.6GFAP, NES, EGFR
6malignant glioma30.6GFAP, NES, ANGPT2, IL13RA2, CDK4, EGFR
7ganglioglioma30.6GFAP
8pilocytic astrocytoma30.5GFAP, NES, CDK4
9medulloblastoma30.5CDK4, IL13RA2, NES, GFAP
10breast cancer30.4CDK6, CDK4, EGFR
11sarcoma30.4CDK4, CDK6, ANGPT2, NES
12adenoma30.3NES, FIGF, ANGPT2, FOSL1, CDK4
13oligodendroglioma30.3GFAP, EGFR
14hemangioblastoma30.3NES, GFAP
15retinoblastoma30.3GFAP, CDK6, CDK4, EGFR, TRRAP
16leukemia30.2CYP27B1, FLT3LG, NES, ANGPT2, CDK6, CDK4
17melanoma30.2CYP27B1, HSPB2, FLT3LG, NES, FIGF, ANGPT2
18adenocarcinoma30.1CYP27B1, CLDN5, NES, FIGF, ANGPT2, FOSL1
19anaplastic oligodendroglioma30.0GFAP, CDK4, EGFR
20lung cancer30.0EGFR, CDK4, FOSL1, ANGPT2, FIGF
21colon cancer30.0CYP27B1, FOSL1, CDK6, CDK4, EGFR
22gemistocytic astrocytoma29.9GFAP
23prostate cancer29.9CYP27B1, HSPB2, NES, FIGF, ANGPT2, IL13RA2
24subependymal giant cell astrocytoma29.9GFAP
25t-cell leukemia29.9FOSL1, CDK6, CDK4
26brain edema29.9GFAP, CLDN5
27ependymoma29.8GFAP, NES, EGFR
28ovarian cancer29.7HSPB2, FIGF, CDK4, EGFR
29colorectal cancer29.7EGFR, CDK4, ANGPT2, FIGF
30pancreatic cancer29.7NES, CDK6, CDK4, EGFR
31brain glioblastoma multiforme10.7
32endotheliitis10.6
33glomerulonephritis10.6
34hypoxia10.6
35cerebritis10.6
36meningioma10.5
37adult spinal cord glioblastoma multiforme10.4
38gliomatosis cerebri10.4
39pleomorphic xanthoastrocytoma10.4
40turcot syndrome10.4
41cytomegalovirus infection10.4
42goodpasture syndrome10.3
43crescentic glomerulonephritis10.3
44rapidly progressive glomerulonephritis10.3
45transitional meningioma10.3
46acoustic neuroma10.3
47muir-torre syndrome10.3
48aplastic anemia10.3
49communicating hydrocephalus10.3
50encephalomyelitis10.3

Graphical network of the top 20 diseases related to Glioblastoma Multiforme:



Diseases related to glioblastoma multiforme

Symptoms for Glioblastoma Multiforme

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Drugs & Therapeutics for Glioblastoma Multiforme

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glioblastoma Multiforme

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Anatomical Context for Glioblastoma Multiforme

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34MalaCards
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MalaCards organs/tissues related to Glioblastoma Multiforme:

34
Brain, Endothelial, Bone, Spinal cord, Lung, Breast, Prostate, Temporal lobe, T cells, Thyroid, Liver, Colon, Pituitary

Animal Models for Glioblastoma Multiforme or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Glioblastoma Multiforme:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.4TRRAP, EGFR, CDK4, CDK6, FOSL1, NES
2MP:00020068.0FIGF, GLIPR1, CDK6, CDK4, EGFR
3MP:00053847.7CYP27B1, GFAP, HSPB2, NES, GLIPR1, CDK6
4MP:00053977.4CYP27B1, TNFSF13, FLT3LG, FOSL1, IL13RA2, CDK6
5MP:00053787.3CYP27B1, GFAP, HSPB2, NES, FIGF, FOSL1
6MP:00053857.2GFAP, HSPB2, CLDN5, FIGF, ANGPT2, FOSL1
7MP:00107686.6NES, CLDN5, HSPB2, GFAP, EBF3, FIGF
8MP:00053876.3EGFR, CYP27B1, GFAP, TNFRSF12A, TNFSF13, HSPB2

Publications for Glioblastoma Multiforme

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53PubMed
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Articles related to Glioblastoma Multiforme:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Illuminating Radiogenomic Characteristics of Glioblastoma Multiforme through Integration of MR Imaging, Messenger RNA Expression, and DNA Copy Number Variation. (24056404)
2014
2
Case Report: Glioblastoma Multiforme Complicating Familial Cavernous Malformations. (23942770)
2013
3
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. (23871826)
2013
4
Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival. (23391370)
2013
5
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. (23940299)
2013
6
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
7
Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis. (22972189)
2012
8
TLR9 expression is associated with prognosis in patients with glioblastoma multiforme. (22169598)
2012
9
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
10
In situ analysis of mutant EGFRs prevalent in glioblastoma multiforme reveals aberrant dimerization, activation, and differential response to anti-EGFR targeted therapy. (22232519)
2012
11
Deciphering the signaling pathways of cancer stem cells of glioblastoma multiforme: role of Akt/mTOR and MAPK pathways. (21035497)
2011
12
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. (19784869)
2010
13
Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme: a report of 7 cases. (19747042)
2010
14
Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. (19655089)
2010
15
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. (18701427)
2009
16
Paradoxical expression of anti-apoptotic and MRP genes on cancer stem-like cell isolated from TJ905 glioblastoma multiforme cell line. (18443953)
2008
17
Bevacizumab and irinotecan therapy in glioblastoma multiforme: a series of 13 cases. (18671639)
2008
18
Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy. (18352856)
2008
19
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. (19074898)
2008
20
Long-term survival with glioblastoma multiforme. (17785346)
2007
21
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. (17048097)
2007
22
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. (17947719)
2007
23
Nestin expression in the cell lines derived from glioblastoma multiforme. (16457706)
2006
24
Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer. (16958968)
2006
25
Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme. (16709029)
2006
26
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. (17111679)
2006
27
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol. (16709245)
2006
28
Activation patterns of epidermal growth factor-receptor signaling in glioblastoma multiforme: in regard to Chakravarti et al. (Int J Radiat Oncol Biol Phys 2005;62:318-327). (15990031)
2005
29
mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. (16199861)
2005
30
Chromogenic in situ hybridization accurately identifies EGFR amplification in small cell glioblastoma multiforme, a common subtype of primary GBM. (16033132)
2005
31
Fascin expression in 90 patients with glioblastoma multiforme. (16308158)
2005
32
PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. (16007122)
2005
33
A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease. (14973082)
2004
34
Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme. (12507885)
2003
35
Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression? (12899520)
2003
36
O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme. (12684420)
2003
37
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. (12466961)
2002
38
Association of elevated glial expression of interleukin-1beta with improved survival in patients with glioblastomas multiforme. (11838804)
2002
39
Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. (12376778)
2002
40
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (11995970)
2001
41
Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme? (11706939)
2001
42
Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report. (11453385)
2001
43
Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. (10663630)
2000
44
Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy. (10730637)
2000
45
Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. (9679546)
1998
46
Somatic mutations of PTEN in glioblastoma multiforme. (9331071)
1997
47
Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study. (7557949)
1995
48
Concentration of elements in human brain: glioblastoma multiforme. (8272844)
1993
49
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
50
Effect of recombinant fibroblast interferon and recombinant immune interferon on growth and the antigenic phenotype of multidrug-resistant human glioblastoma multiforme cells. (1653364)
1991

Variations for Glioblastoma Multiforme

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Expression for genes affiliated with Glioblastoma Multiforme

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glioblastoma Multiforme

Search GEO for disease gene expression data for Glioblastoma Multiforme.

Pathways for genes affiliated with Glioblastoma Multiforme

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51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG
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Pathways related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FOSL1, CDK4, TRRAP
29.6GFAP, TNFSF13, CDK4, EGFR
39.4CDK4, CDK6
4
Show member pathways
Signaling Pathways in Glioblastoma39
9.2EGFR, CDK4, CDK6
5
Show member pathways
9.2CDK6, CDK4, EGFR
69.2EGFR, CDK4, CDK6
7
Show member pathways
8.6TNFRSF12A, TNFSF13, FIGF, ANGPT2, IL13RA2, EGFR
88.5EGFR, CDK4, CDK6, ANGPT2, FIGF
9
Show member pathways
8.2TNFRSF12A, TNFSF13, FIGF, ANGPT2, FOSL1, IL13RA2
108.0FLT3LG, FIGF, CDK6, CDK4, EGFR
11
Show member pathways
8.0TNFRSF12A, TNFSF13, FLT3LG, FIGF, ANGPT2, IL13RA2
12
Show member pathways
6.9EGFR, GFAP, TNFRSF12A, TNFSF13, FIGF, ANGPT2

Compounds for genes affiliated with Glioblastoma Multiforme

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30IUPHAR, 46Novoseek, 12DrugBank, 62Tocris Bioscience, 3BitterDB, 25HMDB, 52PharmGKB
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Compounds related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1methylglyoxal30 4611.2HSPB2, ANGPT2
2temozolomide46 1211.1NES, EGFR
3lead4610.1CDK4, GFAP, CYP27B1
4bromodeoxyuridine4610.0CDK4, NES, GFAP
5fisetin469.8CDK6, CDK4
6genistein46 30 62 3 25 1214.8EGFR, CDK4, GFAP, CYP27B1
7su 9516629.8CDK6, CDK4
8matrigel469.8GFAP, NES, ANGPT2, FOSL1
9purvalanol b629.8CDK6, CDK4
10ro 3306629.8CDK6, CDK4
11kenpaullone46 6210.8CDK6, CDK4
12quercetin46 62 25 1212.7CDK4, HSPB2, GFAP
13retinoid469.7EGFR, CDK4, FOSL1, CYP27B1
14bcnu469.7GFAP, EGFR
15berberine469.7CDK4, CDK6
16purvalanol a62 46 1211.7CDK4, CDK6
17eb 108946 6210.6CDK4, CDK6, CYP27B1
18paraffin469.6CYP27B1, GFAP, NES, ANGPT2, CDK4, EGFR
19silymarin469.6CDK6, CDK4, EGFR
20flavopiridol46 1210.6CDK6, CDK4, EGFR
21cycloheximide469.6EGFR, CDK4, GFAP, CYP27B1
22gefitinib46 52 1211.5CDK6, CDK4, EGFR
23sb 20358046 6210.5EGFR, CDK4, FOSL1, HSPB2
241,25 dihydroxy vitamin d3469.5CYP27B1, CDK6, CDK4
25apigenin46 3010.5CDK4, CDK6
2617-(allylamino)-17-demethoxygeldanamycin469.4CDK4, CDK6, HSPB2
27trastuzumab46 52 1211.4ANGPT2, CDK6, CDK4, EGFR
28progesterone46 30 62 25 1213.4GFAP, NES, FIGF, CDK4, EGFR
29progestin469.4EGFR, CDK4, CDK6, ANGPT2
30glucose469.4CYP27B1, GFAP, HSPB2, NES, ANGPT2, CDK4
31egcg469.4CDK6, CDK4, EGFR
32pd 98,059469.4GFAP, HSPB2, FOSL1, CDK4, EGFR
33herbimycin a46 6210.3CDK6, CDK4, EGFR
34ly294002469.3ANGPT2, CDK6, CDK4, EGFR
35cyclic amp46 2510.2CDK4, FOSL1, GFAP, CYP27B1
36nitric oxide46 25 1211.1NES, FIGF, ANGPT2, FOSL1, CDK4
37cisplatin46 52 62 1212.0GFAP, HSPB2, CDK6, CDK4, EGFR
38thymidine46 259.8CDK4, CDK6, ANGPT2, FLT3LG, GFAP
39retinoic acid46 259.3CYP27B1, GFAP, NES, ANGPT2, FOSL1, CDK6
40vegf468.3GFAP, HSPB2, FLT3LG, NES, FIGF, ANGPT2
41serine468.3GFAP, HSPB2, ANGPT2, FOSL1, CDK6, CDK4
42oxygen46 259.1CYP27B1, GFAP, HSPB2, NES, FIGF, ANGPT2
43calcium46 52 25 1211.0CYP27B1, GFAP, HSPB2, CLDN5, ANGPT2, FOSL1
44estrogen467.8CYP27B1, GFAP, NES, FIGF, ANGPT2, FOSL1
45tyrosine466.8EGFR, CYP27B1, GFAP, HSPB2, FLT3LG, NES

GO Terms for genes affiliated with Glioblastoma Multiforme

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17Gene Ontology
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Cellular components related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.4CDK4, CDK6
2extracellular spaceGO:0056158.1EGFR, IL13RA2, ANGPT2, FIGF, FLT3LG, TNFSF13

Biological processes related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1astrocyte developmentGO:0140029.4CDK6, GFAP
2positive regulation of fibroblast proliferationGO:0481469.1CDK6, CDK4, EGFR
3signal transductionGO:0071658.4EGFR, CDK4, IL13RA2, ANGPT2, FLT3LG, TNFSF13
4positive regulation of cell proliferationGO:0082848.2EGFR, CDK4, FOSL1, FIGF, FLT3LG, TNFSF13

Molecular functions related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:0309719.7ANGPT2, FLT3LG
2cyclin bindingGO:0303329.1CDK4, CDK6

Products for genes affiliated with Glioblastoma Multiforme

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Sources for Glioblastoma Multiforme

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet