MCID: GLB015
MIFTS: 51

Glioblastoma Multiforme malady

Cancer diseases category

Aliases & Classifications for Glioblastoma Multiforme

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 10DISEASES, 56SNOMED-CT, 39NCIt, 33MeSH
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Aliases & Descriptions for Glioblastoma Multiforme:

Name: Glioblastoma Multiforme 8 44 61
Adult Glioblastoma Multiforme 8 10
Primary Glioblastoma Multiforme 8
Grade Iv Adult Astrocytic Tumor 8
Spongioblastoma Multiforme 8
 
Primary Glioblastoma 61
Adult Glioblastoma 61
Glioblastoma 61
Gbm 8


Classifications:



External Ids:

Disease Ontology8 DOID:3068
NCIt39 C3058, C9094
MeSH33 D005909

Summaries for Glioblastoma Multiforme

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Disease Ontology:8 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derived from multiple cell types including astrocytes and oligondroctyes.

MalaCards based summary: Glioblastoma Multiforme, also known as adult glioblastoma multiforme, is related to gliosarcoma and ganglioglioma. An important gene associated with Glioblastoma Multiforme is TRRAP (transformation/transcription domain-associated protein), and among its related pathways are Validated targets of C-MYC transcriptional activation and Spinal Cord Injury. The drug carmustine and the compounds methylglyoxal and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone, and related mouse phenotypes are embryogenesis and tumorigenesis.

Wikipedia:64 Glioblastoma multiforme (GBM), WHO classification name \"glioblastoma\", also known as Grade IV... more...

Related Diseases for Glioblastoma Multiforme

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Diseases related to Glioblastoma Multiforme via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1gliosarcoma31.3CDK4, GFAP
2ganglioglioma31.2GFAP
3giant cell glioblastoma31.1EGFR, GFAP
4astrocytoma31.0GFAP, HSPB2, NES, ANGPT2, IL13RA2, CDK4
5brain cancer30.9GFAP, NES, EGFR
6glioblastoma30.8CYP27B1, GFAP, TNFRSF12A, NES, FIGF, ANGPT2
7pilocytic astrocytoma30.7GFAP, NES, CDK4
8medulloblastoma30.7CDK4, IL13RA2, NES, GFAP
9oligodendroglioma30.7GFAP, EGFR
10hemangioblastoma30.7NES, GFAP
11malignant glioma30.4GFAP, NES, ANGPT2, IL13RA2, CDK4, EGFR
12breast cancer30.3CDK6, CDK4, EGFR
13sarcoma30.2CDK4, CDK6, ANGPT2, NES
14adenoma30.1NES, FIGF, ANGPT2, FOSL1, CDK4
15leukemia29.6CYP27B1, FLT3LG, NES, ANGPT2, CDK6, CDK4
16retinoblastoma29.5GFAP, CDK6, CDK4, EGFR, TRRAP
17melanoma29.0CYP27B1, HSPB2, FLT3LG, NES, FIGF, ANGPT2
18prostate cancer29.0CYP27B1, HSPB2, NES, FIGF, ANGPT2, IL13RA2
19adenocarcinoma28.9CYP27B1, CLDN5, NES, FIGF, ANGPT2, FOSL1
20brain glioblastoma multiforme10.7
21endotheliitis10.6
22glomerulonephritis10.6
23hypoxia10.6
24cerebritis10.6
25brain glioma10.5CLDN5
26adult spinal cord glioblastoma multiforme10.5
27macular holes10.5ANGPT2
28gemistocytic astrocytoma10.5GFAP
29subependymal giant cell astrocytoma10.4GFAP
30goodpasture syndrome10.4
31gliomatosis cerebri10.4
32pleomorphic xanthoastrocytoma10.4
33cytomegalovirus infection10.4
34crescentic glomerulonephritis10.4
35brain edema10.3GFAP, CLDN5
36rapidly progressive glomerulonephritis10.3
37muir-torre syndrome10.3
38insulin-like growth factor i10.3
39glioma susceptibility 110.3
40aplastic anemia10.3
41hydrocephalus10.3
42transitional meningioma10.3
43acoustic neuroma10.3
44communicating hydrocephalus10.3
45meningitis10.3
46neuroma10.3
47prostatitis10.3
48thyroiditis10.3
49malignant peripheral nerve sheath tumor10.3EGFR, NES
50ependymoma10.2GFAP, NES, EGFR

Graphical network of the top 20 diseases related to Glioblastoma Multiforme:



Diseases related to glioblastoma multiforme

Symptoms for Glioblastoma Multiforme

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Drugs & Therapeutics for Glioblastoma Multiforme

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
Gliadel Wafer13 38 CARMUSTINE Rhone-Poulenc Rorer, Guilford Pharmaceuticals Approved February 1997
FDA Label: Gliadel Wafer
Malady that Drug Treats: brain cancer
Indications and Usage:13 GLIADELWaferisanalkylatingdrugindicatedforthetreatmentof:; newly-diagnosedhigh-grade-malignantgliomaasanadjuncttosurgeryand; radiation(1)and; recurrentglioblastomamultiformeasanadjuncttosurgery(1)
DrugBank Targets:11 1. Glutathione reductase, mitochondrial; 2. DNA; 3. RNA
Mechanism of Action:13 
Target: DNA and RNA
Action: alkylating agent
FDA: The activity of GLIADEL Wafer is due to release of cytotoxic concentrations of carmustine, a; DNA and RNA alkylating agent, into the tumor resection cavity. On exposure to the aqueous; environment of the resection cavity, the anhydride bonds in the copolymer are hydrolyzed,; releasing carmustine, carboxyphenoxypropane, and sebacic acid into the surrounding brain; tissue.
2
Temodar13 38 TEMOZOLOMIDE Schering-Plough Approved August 1999
FDA Label: Temodar
Malady that Drug Treats: refractory anaplastic astrocytoma
Indications and Usage:13 TEMODAR is an alkylating drug indicated for the treatment of adult; patients with:; Newly diagnosed glioblastoma multiforme (GBM) concomitantly; with radiotherapy and then as maintenance treatment. (1.1); Refractory anaplastic astrocytoma patients who have experienced; disease progression on a drug regimen containing nitrosourea; and procarbazine. (1.2)
DrugBank Targets:11 1. DNA
Mechanism of Action:13 
Target: DNA
Action: alkylizer
FDA: Temozolomide is not directly active but undergoes rapid nonenzymatic conversion at physiologic pH to the reactive compound; 5-(3-methyltriazen-1-yl)-imidazole-4-carboxamide (MTIC). The cytotoxicity of MTIC is thought to be primarily due to alkylation of; DNA. Alkylation (methylation) occurs mainly at the O6 and N7 positions of guanine. ;

Drug clinical trials:

Search ClinicalTrials for Glioblastoma Multiforme

Search NIH Clinical Center for Glioblastoma Multiforme

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Glioblastoma Multiforme

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Anatomical Context for Glioblastoma Multiforme

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MalaCards organs/tissues related to Glioblastoma Multiforme:

31
Brain, Endothelial, Bone, Spinal cord, Lung, Thyroid, Breast, Prostate, Colon, Liver, T cells, Temporal lobe, Pituitary, Neutrophil

Animal Models for Glioblastoma Multiforme or affiliated genes

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MGI Mouse Phenotypes related to Glioblastoma Multiforme:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.4FOSL1, NES, CDK6, EGFR, TRRAP, CDK4
2MP:00020068.0GLIPR1, CDK6, CDK4, EGFR, FIGF
3MP:00053847.7GFAP, EGFR, CYP27B1, HSPB2, NES, GLIPR1
4MP:00053977.4CDK4, CDK6, FOSL1, FLT3LG, TNFSF13, IL13RA2
5MP:00053787.3FOSL1, NES, EGFR, CDK4, CYP27B1, GFAP
6MP:00053857.2CLDN5, GFAP, HSPB2, FIGF, EGFR, CDK4
7MP:00107686.6EBF3, EGFR, CDK4, CDK6, FOSL1, ANGPT2
8MP:00053876.3ANGPT2, GFAP, TNFRSF12A, TNFSF13, HSPB2, FLT3LG

Publications for Glioblastoma Multiforme

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Articles related to Glioblastoma Multiforme:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells. (25898313)
2015
2
Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth. (25787115)
2015
3
Differentiation of solitary brain metastasis from glioblastoma multiforme: a predictive multiparametric approach using combined MR diffusion and perfusion. (25845813)
2015
4
Dendritic cell vaccination combined with temozolomide retreatment: results of a phase I trial in patients with recurrent glioblastoma multiforme. (25366363)
2014
5
Haematological toxicity of Valproic acid compared to Levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study. (25359262)
2014
6
Feasibility of extreme dose escalation for glioblastoma multiforme using 4A? radiotherapy. (25377756)
2014
7
Case Report: Glioblastoma Multiforme Complicating Familial Cavernous Malformations. (23942770)
2013
8
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. (23871826)
2013
9
Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients. (23494873)
2013
10
Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival. (23391370)
2013
11
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. (23940299)
2013
12
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
13
Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis. (22972189)
2012
14
TLR9 expression is associated with prognosis in patients with glioblastoma multiforme. (22169598)
2012
15
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
16
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. (19784869)
2010
17
Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme: a report of 7 cases. (19747042)
2010
18
Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. (19655089)
2010
19
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. (18701427)
2009
20
Paradoxical expression of anti-apoptotic and MRP genes on cancer stem-like cell isolated from TJ905 glioblastoma multiforme cell line. (18443953)
2008
21
Bevacizumab and irinotecan therapy in glioblastoma multiforme: a series of 13 cases. (18671639)
2008
22
Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy. (18352856)
2008
23
Long-term survival with glioblastoma multiforme. (17785346)
2007
24
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. (17048097)
2007
25
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. (17947719)
2007
26
Nestin expression in the cell lines derived from glioblastoma multiforme. (16457706)
2006
27
Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer. (16958968)
2006
28
Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme. (16709029)
2006
29
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. (17111679)
2006
30
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol. (16709245)
2006
31
Activation patterns of epidermal growth factor-receptor signaling in glioblastoma multiforme: in regard to Chakravarti et al. (Int J Radiat Oncol Biol Phys 2005;62:318-327). (15990031)
2005
32
mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. (16199861)
2005
33
Chromogenic in situ hybridization accurately identifies EGFR amplification in small cell glioblastoma multiforme, a common subtype of primary GBM. (16033132)
2005
34
Fascin expression in 90 patients with glioblastoma multiforme. (16308158)
2005
35
A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease. (14973082)
2004
36
Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme. (12507885)
2003
37
Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression? (12899520)
2003
38
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. (12466961)
2002
39
Association of elevated glial expression of interleukin-1beta with improved survival in patients with glioblastomas multiforme. (11838804)
2002
40
Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. (12376778)
2002
41
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (11995970)
2001
42
Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme? (11706939)
2001
43
Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. (10663630)
2000
44
Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy. (10730637)
2000
45
Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. (9679546)
1998
46
Somatic mutations of PTEN in glioblastoma multiforme. (9331071)
1997
47
Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study. (7557949)
1995
48
Concentration of elements in human brain: glioblastoma multiforme. (8272844)
1993
49
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
50
Effect of recombinant fibroblast interferon and recombinant immune interferon on growth and the antigenic phenotype of multidrug-resistant human glioblastoma multiforme cells. (1653364)
1991

Variations for Glioblastoma Multiforme

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Expression for genes affiliated with Glioblastoma Multiforme

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Search GEO for disease gene expression data for Glioblastoma Multiforme.

Pathways for genes affiliated with Glioblastoma Multiforme

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Pathways related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FOSL1, CDK4, TRRAP
29.6GFAP, TNFSF13, CDK4, EGFR
39.4CDK4, CDK6
4
Show member pathways
Signaling Pathways in Glioblastoma36
9.2EGFR, CDK4, CDK6
5
Show member pathways
9.2CDK6, CDK4, EGFR
69.2EGFR, CDK4, CDK6
7
Show member pathways
8.6TNFRSF12A, TNFSF13, FIGF, ANGPT2, IL13RA2, EGFR
88.5EGFR, CDK4, CDK6, ANGPT2, FIGF
9
Show member pathways
8.2TNFRSF12A, TNFSF13, FIGF, ANGPT2, FOSL1, IL13RA2
108.0FLT3LG, FIGF, CDK6, CDK4, EGFR
11
Show member pathways
8.0TNFRSF12A, TNFSF13, FLT3LG, FIGF, ANGPT2, IL13RA2
12
Show member pathways
6.9EGFR, GFAP, TNFRSF12A, TNFSF13, FIGF, ANGPT2

Compounds for genes affiliated with Glioblastoma Multiforme

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Compounds related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(show all 45)
idCompoundScoreTop Affiliating Genes
1methylglyoxal28 4411.2ANGPT2, HSPB2
2temozolomide44 1111.1EGFR, NES
3lead4410.1CDK4, CYP27B1, GFAP
4bromodeoxyuridine4410.0GFAP, NES, CDK4
5fisetin449.8CDK6, CDK4
6genistein44 28 60 1 24 1114.8CYP27B1, EGFR, CDK4, GFAP
7purvalanol b609.8CDK6, CDK4
8matrigel449.8FOSL1, ANGPT2, NES, GFAP
9ro 3306609.8CDK6, CDK4
10su 9516609.8CDK6, CDK4
11kenpaullone44 6010.8CDK4, CDK6
12quercetin44 60 24 1112.7CDK4, HSPB2, GFAP
13retinoid449.7FOSL1, EGFR, CYP27B1, CDK4
14bcnu449.7EGFR, GFAP
15berberine449.7CDK6, CDK4
16purvalanol a60 44 1111.7CDK6, CDK4
17eb 108944 6010.6CDK4, CDK6, CYP27B1
18paraffin449.6CDK4, ANGPT2, NES, GFAP, EGFR, CYP27B1
19silymarin449.6EGFR, CDK4, CDK6
20flavopiridol44 1110.6CDK6, EGFR, CDK4
21cycloheximide449.6CDK4, GFAP, CYP27B1, EGFR
22gefitinib44 50 1111.5CDK6, EGFR, CDK4
23sb 20358044 6010.5EGFR, FOSL1, CDK4, HSPB2
241,25 dihydroxy vitamin d3449.5CYP27B1, CDK6, CDK4
25apigenin44 2810.5CDK6, CDK4
2617-(allylamino)-17-demethoxygeldanamycin449.4HSPB2, CDK6, CDK4
27trastuzumab44 50 1111.4CDK4, ANGPT2, CDK6, EGFR
28progesterone44 28 60 24 1113.4EGFR, CDK4, FIGF, GFAP, NES
29progestin449.4ANGPT2, CDK6, CDK4, EGFR
30glucose449.4GFAP, HSPB2, NES, ANGPT2, CDK4, CYP27B1
31egcg449.4CDK6, CDK4, EGFR
32pd 98,059449.4GFAP, EGFR, HSPB2, CDK4, FOSL1
33herbimycin a44 6010.3CDK6, EGFR, CDK4
34ly294002449.3ANGPT2, EGFR, CDK6, CDK4
35cyclic amp44 2410.2CYP27B1, FOSL1, GFAP, CDK4
36nitric oxide44 24 1111.1ANGPT2, FIGF, FOSL1, NES, CDK4
37cisplatin44 50 60 1112.0CDK6, EGFR, CDK4, GFAP, HSPB2
38thymidine44 249.8CDK4, GFAP, CDK6, FLT3LG, ANGPT2
39retinoic acid44 249.3CDK4, CDK6, ANGPT2, NES, EGFR, CYP27B1
40vegf448.3ANGPT2, CDK4, HSPB2, GFAP, NES, FIGF
41serine448.3EGFR, CDK4, CDK6, ANGPT2, HSPB2, GFAP
42oxygen44 249.1HSPB2, GFAP, CYP27B1, ANGPT2, NES, CDK4
43calcium44 50 24 1111.0GFAP, CYP27B1, HSPB2, CLDN5, CDK4, FOSL1
44estrogen447.8CYP27B1, GFAP, FOSL1, NES, FIGF, ANGPT2
45tyrosine446.8FOSL1, FIGF, CDK4, CDK6, ANGPT2, NES

GO Terms for genes affiliated with Glioblastoma Multiforme

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Cellular components related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00003079.4CDK4, CDK6
2extracellular spaceGO:00056158.1EGFR, IL13RA2, ANGPT2, FIGF, FLT3LG, TNFSF13

Biological processes related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1astrocyte developmentGO:00140029.4CDK6, GFAP
2positive regulation of fibroblast proliferationGO:00481469.1CDK6, CDK4, EGFR
3signal transductionGO:00071658.4EGFR, CDK4, IL13RA2, ANGPT2, FLT3LG, TNFSF13
4positive regulation of cell proliferationGO:00082848.2EGFR, CDK4, FOSL1, FIGF, FLT3LG, TNFSF13

Molecular functions related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.7ANGPT2, FLT3LG
2cyclin bindingGO:00303329.1CDK4, CDK6

Sources for Glioblastoma Multiforme

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet