MCID: GLB015
MIFTS: 51

Glioblastoma Multiforme malady

Cancer diseases category

Aliases & Classifications for Glioblastoma Multiforme

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 11DISEASES, 55SNOMED-CT, 38NCIt, 33MeSH
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Glioblastoma Multiforme, Aliases & Descriptions:

Name: Glioblastoma Multiforme 9 43 60
Adult Glioblastoma Multiforme 9 11
Primary Glioblastoma Multiforme 9
Grade Iv Adult Astrocytic Tumor 9
Spongioblastoma Multiforme 9
 
Primary Glioblastoma 60
Adult Glioblastoma 60
Glioblastoma 60
Gbm 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:3068
NCIt38 C3058, C9094
MeSH33 D005909

Summaries for Glioblastoma Multiforme

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Disease Ontology:9 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derived from multiple cell types including astrocytes and oligondroctyes.

MalaCards based summary: Glioblastoma Multiforme, also known as adult glioblastoma multiforme, is related to gliosarcoma and ganglioglioma. An important gene associated with Glioblastoma Multiforme is TRRAP (transformation/transcription domain-associated protein), and among its related pathways are Validated targets of C-MYC transcriptional activation and Spinal Cord Injury. The drug carmustine and the compounds methylglyoxal and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone, and related mouse phenotypes are embryogenesis and tumorigenesis.

Wikipedia:63 Glioblastoma multiforme (GBM), WHO classification name \"glioblastoma\", also known as Grade IV... more...

Related Diseases for Glioblastoma Multiforme

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Diseases related to Glioblastoma Multiforme via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1gliosarcoma31.3CDK4, GFAP
2ganglioglioma31.2GFAP
3giant cell glioblastoma31.1EGFR, GFAP
4astrocytoma31.0GFAP, HSPB2, NES, ANGPT2, IL13RA2, CDK4
5brain cancer30.9GFAP, NES, EGFR
6glioblastoma30.8CYP27B1, GFAP, TNFRSF12A, NES, FIGF, ANGPT2
7pilocytic astrocytoma30.7GFAP, NES, CDK4
8medulloblastoma30.7CDK4, IL13RA2, NES, GFAP
9oligodendroglioma30.7GFAP, EGFR
10hemangioblastoma30.7NES, GFAP
11malignant glioma30.4GFAP, NES, ANGPT2, IL13RA2, CDK4, EGFR
12breast cancer30.3CDK6, CDK4, EGFR
13sarcoma30.2CDK4, CDK6, ANGPT2, NES
14adenoma30.1NES, FIGF, ANGPT2, FOSL1, CDK4
15leukemia29.6CYP27B1, FLT3LG, NES, ANGPT2, CDK6, CDK4
16retinoblastoma29.5GFAP, CDK6, CDK4, EGFR, TRRAP
17melanoma29.0CYP27B1, HSPB2, FLT3LG, NES, FIGF, ANGPT2
18prostate cancer29.0CYP27B1, HSPB2, NES, FIGF, ANGPT2, IL13RA2
19adenocarcinoma28.9CYP27B1, CLDN5, NES, FIGF, ANGPT2, FOSL1
20brain glioblastoma multiforme10.7
21endotheliitis10.6
22glomerulonephritis10.6
23hypoxia10.6
24cerebritis10.6
25brain glioma10.5CLDN5
26adult spinal cord glioblastoma multiforme10.5
27macular holes10.5ANGPT2
28gemistocytic astrocytoma10.5GFAP
29subependymal giant cell astrocytoma10.4GFAP
30goodpasture syndrome10.4
31gliomatosis cerebri10.4
32pleomorphic xanthoastrocytoma10.4
33cytomegalovirus infection10.4
34crescentic glomerulonephritis10.4
35brain edema10.3GFAP, CLDN5
36rapidly progressive glomerulonephritis10.3
37muir-torre syndrome10.3
38insulin-like growth factor i10.3
39glioma susceptibility 110.3
40aplastic anemia10.3
41hydrocephalus10.3
42transitional meningioma10.3
43acoustic neuroma10.3
44communicating hydrocephalus10.3
45meningitis10.3
46neuroma10.3
47prostatitis10.3
48thyroiditis10.3
49malignant peripheral nerve sheath tumor10.3EGFR, NES
50ependymoma10.2GFAP, NES, EGFR

Graphical network of the top 20 diseases related to Glioblastoma Multiforme:



Diseases related to glioblastoma multiforme

Symptoms for Glioblastoma Multiforme

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Drugs & Therapeutics for Glioblastoma Multiforme

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Drug clinical trials:

Search ClinicalTrials for Glioblastoma Multiforme

Search NIH Clinical Center for Glioblastoma Multiforme

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Glioblastoma Multiforme

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Anatomical Context for Glioblastoma Multiforme

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MalaCards organs/tissues related to Glioblastoma Multiforme:

31
Brain, Endothelial, Bone, Spinal cord, Lung, Thyroid, Breast, Prostate, Colon, Liver, T cells, Temporal lobe, Pituitary, Neutrophil

Animal Models for Glioblastoma Multiforme or affiliated genes

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MGI Mouse Phenotypes related to Glioblastoma Multiforme:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.4TRRAP, EGFR, CDK4, CDK6, FOSL1, NES
2MP:00020068.0FIGF, GLIPR1, CDK6, CDK4, EGFR
3MP:00053847.7CYP27B1, GFAP, HSPB2, NES, GLIPR1, CDK6
4MP:00053977.4CYP27B1, TNFSF13, FLT3LG, FOSL1, IL13RA2, CDK6
5MP:00053787.3CYP27B1, GFAP, HSPB2, NES, FIGF, FOSL1
6MP:00053857.2GFAP, HSPB2, CLDN5, FIGF, ANGPT2, FOSL1
7MP:00107686.6NES, CLDN5, HSPB2, GFAP, EBF3, FIGF
8MP:00053876.3EGFR, CYP27B1, GFAP, TNFRSF12A, TNFSF13, HSPB2

Publications for Glioblastoma Multiforme

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Articles related to Glioblastoma Multiforme:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells. (25898313)
2015
2
Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth. (25787115)
2015
3
Differentiation of solitary brain metastasis from glioblastoma multiforme: a predictive multiparametric approach using combined MR diffusion and perfusion. (25845813)
2015
4
Dendritic cell vaccination combined with temozolomide retreatment: results of a phase I trial in patients with recurrent glioblastoma multiforme. (25366363)
2014
5
Haematological toxicity of Valproic acid compared to Levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study. (25359262)
2014
6
Feasibility of extreme dose escalation for glioblastoma multiforme using 4A? radiotherapy. (25377756)
2014
7
Case Report: Glioblastoma Multiforme Complicating Familial Cavernous Malformations. (23942770)
2013
8
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. (23871826)
2013
9
Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients. (23494873)
2013
10
Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival. (23391370)
2013
11
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. (23940299)
2013
12
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
13
Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis. (22972189)
2012
14
TLR9 expression is associated with prognosis in patients with glioblastoma multiforme. (22169598)
2012
15
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
16
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. (19784869)
2010
17
Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme: a report of 7 cases. (19747042)
2010
18
Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. (19655089)
2010
19
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. (18701427)
2009
20
Paradoxical expression of anti-apoptotic and MRP genes on cancer stem-like cell isolated from TJ905 glioblastoma multiforme cell line. (18443953)
2008
21
Bevacizumab and irinotecan therapy in glioblastoma multiforme: a series of 13 cases. (18671639)
2008
22
Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy. (18352856)
2008
23
Long-term survival with glioblastoma multiforme. (17785346)
2007
24
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. (17048097)
2007
25
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. (17947719)
2007
26
Nestin expression in the cell lines derived from glioblastoma multiforme. (16457706)
2006
27
Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer. (16958968)
2006
28
Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme. (16709029)
2006
29
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. (17111679)
2006
30
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol. (16709245)
2006
31
Activation patterns of epidermal growth factor-receptor signaling in glioblastoma multiforme: in regard to Chakravarti et al. (Int J Radiat Oncol Biol Phys 2005;62:318-327). (15990031)
2005
32
mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. (16199861)
2005
33
Chromogenic in situ hybridization accurately identifies EGFR amplification in small cell glioblastoma multiforme, a common subtype of primary GBM. (16033132)
2005
34
Fascin expression in 90 patients with glioblastoma multiforme. (16308158)
2005
35
A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease. (14973082)
2004
36
Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme. (12507885)
2003
37
Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression? (12899520)
2003
38
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. (12466961)
2002
39
Association of elevated glial expression of interleukin-1beta with improved survival in patients with glioblastomas multiforme. (11838804)
2002
40
Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. (12376778)
2002
41
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (11995970)
2001
42
Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme? (11706939)
2001
43
Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. (10663630)
2000
44
Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy. (10730637)
2000
45
Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. (9679546)
1998
46
Somatic mutations of PTEN in glioblastoma multiforme. (9331071)
1997
47
Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study. (7557949)
1995
48
Concentration of elements in human brain: glioblastoma multiforme. (8272844)
1993
49
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
50
Effect of recombinant fibroblast interferon and recombinant immune interferon on growth and the antigenic phenotype of multidrug-resistant human glioblastoma multiforme cells. (1653364)
1991

Variations for Glioblastoma Multiforme

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Expression for genes affiliated with Glioblastoma Multiforme

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Search GEO for disease gene expression data for Glioblastoma Multiforme.

Pathways for genes affiliated with Glioblastoma Multiforme

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Pathways related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FOSL1, CDK4, TRRAP
29.6TNFSF13, GFAP, EGFR, CDK4
39.4CDK4, CDK6
4
Show member pathways
Signaling Pathways in Glioblastoma36
9.2EGFR, CDK4, CDK6
5
Show member pathways
9.2EGFR, CDK4, CDK6
69.2CDK6, CDK4, EGFR
7
Show member pathways
8.6FIGF, ANGPT2, TNFSF13, IL13RA2, TNFRSF12A, EGFR
88.5FIGF, ANGPT2, EGFR, CDK6, CDK4
9
Show member pathways
8.2FOSL1, TNFRSF12A, ANGPT2, EGFR, IL13RA2, TNFSF13
108.0EGFR, CDK4, CDK6, FLT3LG, FIGF
11
Show member pathways
8.0ANGPT2, EGFR, FIGF, TNFSF13, IL13RA2, TNFRSF12A
12
Show member pathways
6.9FOSL1, CDK4, CDK6, IL13RA2, ANGPT2, FIGF

Compounds for genes affiliated with Glioblastoma Multiforme

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Compounds related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(show all 45)
idCompoundScoreTop Affiliating Genes
1methylglyoxal28 4311.2HSPB2, ANGPT2
2temozolomide43 1211.1NES, EGFR
3lead4310.1CDK4, GFAP, CYP27B1
4bromodeoxyuridine4310.0CDK4, NES, GFAP
5fisetin439.8CDK6, CDK4
6genistein43 28 59 2 24 1214.8EGFR, CDK4, GFAP, CYP27B1
7su 9516599.8CDK6, CDK4
8matrigel439.8GFAP, NES, ANGPT2, FOSL1
9purvalanol b599.8CDK6, CDK4
10ro 3306599.8CDK6, CDK4
11kenpaullone43 5910.8CDK6, CDK4
12quercetin43 59 24 1212.7CDK4, HSPB2, GFAP
13retinoid439.7EGFR, CDK4, FOSL1, CYP27B1
14bcnu439.7GFAP, EGFR
15berberine439.7CDK4, CDK6
16purvalanol a59 43 1211.7CDK4, CDK6
17eb 108943 5910.6CDK4, CDK6, CYP27B1
18paraffin439.6CYP27B1, GFAP, NES, ANGPT2, CDK4, EGFR
19silymarin439.6CDK6, CDK4, EGFR
20flavopiridol43 1210.6CDK6, CDK4, EGFR
21cycloheximide439.6EGFR, CDK4, GFAP, CYP27B1
22gefitinib43 49 1211.5CDK6, CDK4, EGFR
23sb 20358043 5910.5EGFR, CDK4, FOSL1, HSPB2
241,25 dihydroxy vitamin d3439.5CYP27B1, CDK6, CDK4
25apigenin43 2810.5CDK4, CDK6
2617-(allylamino)-17-demethoxygeldanamycin439.4CDK4, CDK6, HSPB2
27trastuzumab43 49 1211.4ANGPT2, CDK6, CDK4, EGFR
28progesterone43 28 59 24 1213.4GFAP, NES, FIGF, CDK4, EGFR
29progestin439.4EGFR, CDK4, CDK6, ANGPT2
30glucose439.4CYP27B1, GFAP, HSPB2, NES, ANGPT2, CDK4
31egcg439.4CDK6, CDK4, EGFR
32pd 98,059439.4GFAP, HSPB2, FOSL1, CDK4, EGFR
33herbimycin a43 5910.3CDK6, CDK4, EGFR
34ly294002439.3ANGPT2, CDK6, CDK4, EGFR
35cyclic amp43 2410.2CDK4, FOSL1, GFAP, CYP27B1
36nitric oxide43 24 1211.1NES, FIGF, ANGPT2, FOSL1, CDK4
37cisplatin43 49 59 1212.0GFAP, HSPB2, CDK6, CDK4, EGFR
38thymidine43 249.8CDK4, CDK6, ANGPT2, FLT3LG, GFAP
39retinoic acid43 249.3CYP27B1, GFAP, NES, ANGPT2, FOSL1, CDK6
40vegf438.3GFAP, HSPB2, FLT3LG, NES, FIGF, ANGPT2
41serine438.3GFAP, HSPB2, ANGPT2, FOSL1, CDK6, CDK4
42oxygen43 249.1CYP27B1, GFAP, HSPB2, NES, FIGF, ANGPT2
43calcium43 49 24 1211.0CYP27B1, GFAP, HSPB2, CLDN5, ANGPT2, FOSL1
44estrogen437.8CYP27B1, GFAP, NES, FIGF, ANGPT2, FOSL1
45tyrosine436.8EGFR, CYP27B1, GFAP, HSPB2, FLT3LG, NES

GO Terms for genes affiliated with Glioblastoma Multiforme

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Cellular components related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00003079.4CDK4, CDK6
2extracellular spaceGO:00056158.1EGFR, IL13RA2, ANGPT2, FIGF, FLT3LG, TNFSF13

Biological processes related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1astrocyte developmentGO:00140029.4CDK6, GFAP
2positive regulation of fibroblast proliferationGO:00481469.1CDK4, EGFR, CDK6
3signal transductionGO:00071658.4TNFSF13, FLT3LG, ANGPT2, IL13RA2, CDK4, EGFR
4positive regulation of cell proliferationGO:00082848.2FOSL1, TNFSF13, FLT3LG, FIGF, EGFR, CDK4

Molecular functions related to Glioblastoma Multiforme according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.7ANGPT2, FLT3LG
2cyclin bindingGO:00303329.1CDK4, CDK6

Products for genes affiliated with Glioblastoma Multiforme

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Sources for Glioblastoma Multiforme

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet