GBM
MCID: GLB015
MIFTS: 58

Glioblastoma Multiforme (GBM) malady

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Summaries for Glioblastoma Multiforme

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Disease Ontology:8 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derived from multiple cell types including astrocytes and oligondroctyes.

MalaCards based summary: Glioblastoma Multiforme, also known as primary glioblastoma multiforme, is related to gliosarcoma and ganglioglioma. An important gene associated with Glioblastoma Multiforme is TRRAP (transformation/transcription domain-associated protein), and among its related pathways are Validated targets of C-MYC transcriptional activation and Spinal Cord Injury. The compounds methylglyoxal and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone, and related mouse phenotypes are embryogenesis and tumorigenesis.

Wikipedia:65 Glioblastoma multiforme (GBM), WHO classification name \"glioblastoma\", also known as Grade IV... more...

Aliases & Classifications for Glioblastoma Multiforme

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 10DISEASES, 57SNOMED-CT, 39NCIt, 34MeSH
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Glioblastoma Multiforme, Aliases & Descriptions:

Name: Glioblastoma Multiforme 8 44 62
Primary Glioblastoma Multiforme 8 62
Adult Glioblastoma Multiforme 8 10
Spongioblastoma Multiforme 8 62
 
Grade Iv Adult Astrocytic Tumor 8
Glioblastoma Multiforme, Adult 62
Gbm 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3068
NCIt39 C3058, C9094
MeSH34 D005909

Related Diseases for Glioblastoma Multiforme

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Diseases related to Glioblastoma Multiforme via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1gliosarcoma31.3CDK4, GFAP
2ganglioglioma31.1GFAP
3giant cell glioblastoma31.1EGFR, GFAP
4astrocytoma31.0EGFR, CDK4, IL13RA2, ANGPT2, HSPB2, GFAP
5brain cancer30.9NES, GFAP, EGFR
6glioblastoma30.8EGFR, CDK4, CDK6, IL13RA2, FIGF, NES
7pilocytic astrocytoma30.8GFAP, CDK4, NES
8medulloblastoma30.8GFAP, NES, CDK4, IL13RA2
9oligodendroglioma30.7EGFR, GFAP
10malignant glioma30.4CDK4, EGFR, GFAP, NES, ANGPT2, IL13RA2
11breast cancer30.3CDK4, CDK6, EGFR
12sarcoma30.2CDK6, ANGPT2, CDK4, NES
13adenoma30.2CDK4, FOSL1, ANGPT2, FIGF, NES
14leukemia29.7CDK4, FLT3LG, CYP27B1, NES, ANGPT2, CDK6
15retinoblastoma29.5CDK4, CDK6, TRRAP, EGFR, GFAP
16melanoma29.0CDK6, CDK4, FOSL1, ANGPT2, FIGF, CYP27B1
17prostate cancer29.0CYP27B1, NES, FIGF, ANGPT2, IL13RA2, EGFR
18adenocarcinoma28.9ANGPT2, CDK6, IL13RA2, CYP27B1, CDK4, EGFR
19brain glioblastoma multiforme10.7
20endotheliitis10.6
21glomerulonephritis10.6
22hypoxia10.6
23cerebritis10.6
24brain glioma10.5CLDN5
25meningioma10.5
26adult spinal cord glioblastoma multiforme10.5
27macular holes10.5ANGPT2
28gemistocytic astrocytoma10.5GFAP
29subependymal giant cell astrocytoma10.4GFAP
30gliomatosis cerebri10.4
31pleomorphic xanthoastrocytoma10.4
32turcot syndrome10.4
33cytomegalovirus infection10.4
34glioma somatic10.4
35crescentic glomerulonephritis10.4
36brain edema10.3CLDN5, GFAP
37hemangioblastoma10.3GFAP, NES
38goodpasture syndrome10.3
39rapidly progressive glomerulonephritis10.3
40aplastic anemia10.3
41hydrocephalus10.3
42muir-torre syndrome10.3
43transitional meningioma10.3
44acoustic neuroma10.3
45communicating hydrocephalus10.3
46meningitis10.3
47neuroma10.3
48prostatitis10.3
49malignant peripheral nerve sheath tumor10.3EGFR, NES
50ependymoma10.2NES, GFAP, EGFR

Graphical network of the top 20 diseases related to Glioblastoma Multiforme:



Diseases related to glioblastoma multiforme

Symptoms for Glioblastoma Multiforme

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Drugs & Therapeutics for Glioblastoma Multiforme

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Drug clinical trials:

Search ClinicalTrials for Glioblastoma Multiforme

Search NIH Clinical Center for Glioblastoma Multiforme

Genetic Tests for Glioblastoma Multiforme

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Anatomical Context for Glioblastoma Multiforme

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MalaCards organs/tissues related to Glioblastoma Multiforme:

32
Brain, Endothelial, Bone, Spinal cord, Lung, Breast, Prostate, Colon, Liver, Thyroid, T cells, Temporal lobe, Pituitary, Neutrophil

Animal Models for Glioblastoma Multiforme or affiliated genes

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MGI Mouse Phenotypes related to Glioblastoma Multiforme:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.4TRRAP, EGFR, CDK4, CDK6, FOSL1, NES
2MP:00020068.0FIGF, GLIPR1, CDK6, CDK4, EGFR
3MP:00053847.7CYP27B1, GFAP, HSPB2, NES, GLIPR1, CDK6
4MP:00053977.4CYP27B1, TNFSF13, FLT3LG, FOSL1, IL13RA2, CDK6
5MP:00053787.3CYP27B1, GFAP, HSPB2, NES, FIGF, FOSL1
6MP:00053857.2GFAP, HSPB2, CLDN5, FIGF, ANGPT2, FOSL1
7MP:00107686.6NES, CLDN5, HSPB2, GFAP, EBF3, FIGF
8MP:00053876.3EGFR, CYP27B1, GFAP, TNFRSF12A, TNFSF13, HSPB2

Publications for Glioblastoma Multiforme

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Articles related to Glioblastoma Multiforme:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Dendritic cell vaccination combined with temozolomide retreatment: results of a phase I trial in patients with recurrent glioblastoma multiforme. (25366363)
2014
2
Haematological toxicity of Valproic acid compared to Levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study. (25359262)
2014
3
Feasibility of extreme dose escalation for glioblastoma multiforme using 4A? radiotherapy. (25377756)
2014
4
Case Report: Glioblastoma Multiforme Complicating Familial Cavernous Malformations. (23942770)
2013
5
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. (23871826)
2013
6
Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients. (23494873)
2013
7
Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival. (23391370)
2013
8
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. (23940299)
2013
9
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
10
Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis. (22972189)
2012
11
TLR9 expression is associated with prognosis in patients with glioblastoma multiforme. (22169598)
2012
12
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
13
Deciphering the signaling pathways of cancer stem cells of glioblastoma multiforme: role of Akt/mTOR and MAPK pathways. (21035497)
2011
14
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. (19784869)
2010
15
Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme: a report of 7 cases. (19747042)
2010
16
Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. (19655089)
2010
17
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. (18701427)
2009
18
Paradoxical expression of anti-apoptotic and MRP genes on cancer stem-like cell isolated from TJ905 glioblastoma multiforme cell line. (18443953)
2008
19
Bevacizumab and irinotecan therapy in glioblastoma multiforme: a series of 13 cases. (18671639)
2008
20
Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy. (18352856)
2008
21
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. (19074898)
2008
22
Long-term survival with glioblastoma multiforme. (17785346)
2007
23
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. (17048097)
2007
24
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. (17947719)
2007
25
Nestin expression in the cell lines derived from glioblastoma multiforme. (16457706)
2006
26
Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer. (16958968)
2006
27
Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme. (16709029)
2006
28
Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. (17111679)
2006
29
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol. (16709245)
2006
30
Activation patterns of epidermal growth factor-receptor signaling in glioblastoma multiforme: in regard to Chakravarti et al. (Int J Radiat Oncol Biol Phys 2005;62:318-327). (15990031)
2005
31
mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. (16199861)
2005
32
Chromogenic in situ hybridization accurately identifies EGFR amplification in small cell glioblastoma multiforme, a common subtype of primary GBM. (16033132)
2005
33
Fascin expression in 90 patients with glioblastoma multiforme. (16308158)
2005
34
PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. (16007122)
2005
35
A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease. (14973082)
2004
36
Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme. (12507885)
2003
37
Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression? (12899520)
2003
38
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. (12466961)
2002
39
Association of elevated glial expression of interleukin-1beta with improved survival in patients with glioblastomas multiforme. (11838804)
2002
40
Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. (12376778)
2002
41
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (11995970)
2001
42
Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme? (11706939)
2001
43
Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. (10663630)
2000
44
Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy. (10730637)
2000
45
Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. (9679546)
1998
46
Somatic mutations of PTEN in glioblastoma multiforme. (9331071)
1997
47
Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study. (7557949)
1995
48
Concentration of elements in human brain: glioblastoma multiforme. (8272844)
1993
49
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
50
Effect of recombinant fibroblast interferon and recombinant immune interferon on growth and the antigenic phenotype of multidrug-resistant human glioblastoma multiforme cells. (1653364)
1991

Variations for Glioblastoma Multiforme

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Expression for genes affiliated with Glioblastoma Multiforme

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Expression patterns in normal tissues for genes affiliated with Glioblastoma Multiforme

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Pathways for genes affiliated with Glioblastoma Multiforme

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Pathways related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FOSL1, CDK4, TRRAP
29.6TNFSF13, GFAP, EGFR, CDK4
39.4CDK4, CDK6
4
Show member pathways
Signaling Pathways in Glioblastoma37
9.2EGFR, CDK4, CDK6
5
Show member pathways
9.2EGFR, CDK4, CDK6
69.2CDK6, CDK4, EGFR
7
Show member pathways
8.6FIGF, ANGPT2, TNFSF13, IL13RA2, TNFRSF12A, EGFR
88.5FIGF, ANGPT2, EGFR, CDK6, CDK4
9
Show member pathways
8.2FOSL1, TNFRSF12A, ANGPT2, EGFR, IL13RA2, TNFSF13
108.0EGFR, CDK4, CDK6, FLT3LG, FIGF
11
Show member pathways
8.0ANGPT2, EGFR, FIGF, TNFSF13, IL13RA2, TNFRSF12A
12
Show member pathways
6.9FOSL1, CDK4, CDK6, IL13RA2, ANGPT2, FIGF

Compounds for genes affiliated with Glioblastoma Multiforme

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Compounds related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1methylglyoxal28 4411.2HSPB2, ANGPT2
2temozolomide44 1111.1NES, EGFR
3lead4410.1CDK4, GFAP, CYP27B1
4bromodeoxyuridine4410.0CDK4, NES, GFAP
5fisetin449.8CDK6, CDK4
6genistein44 28 61 2 24 1114.8EGFR, CDK4, GFAP, CYP27B1
7su 9516619.8CDK6, CDK4
8matrigel449.8GFAP, NES, ANGPT2, FOSL1
9purvalanol b619.8CDK6, CDK4
10ro 3306619.8CDK6, CDK4
11kenpaullone44 6110.8CDK6, CDK4
12quercetin44 61 24 1112.7CDK4, HSPB2, GFAP
13retinoid449.7EGFR, CDK4, FOSL1, CYP27B1
14bcnu449.7GFAP, EGFR
15berberine449.7CDK4, CDK6
16purvalanol a61 44 1111.7CDK4, CDK6
17eb 108944 6110.6CDK4, CDK6, CYP27B1
18paraffin449.6CYP27B1, GFAP, NES, ANGPT2, CDK4, EGFR
19silymarin449.6CDK6, CDK4, EGFR
20flavopiridol44 1110.6CDK6, CDK4, EGFR
21cycloheximide449.6EGFR, CDK4, GFAP, CYP27B1
22gefitinib44 50 1111.5CDK6, CDK4, EGFR
23sb 20358044 6110.5EGFR, CDK4, FOSL1, HSPB2
241,25 dihydroxy vitamin d3449.5CYP27B1, CDK6, CDK4
25apigenin44 2810.5CDK4, CDK6
2617-(allylamino)-17-demethoxygeldanamycin449.4CDK4, CDK6, HSPB2
27trastuzumab44 50 1111.4ANGPT2, CDK6, CDK4, EGFR
28progesterone44 28 61 24 1113.4GFAP, NES, FIGF, CDK4, EGFR
29progestin449.4EGFR, CDK4, CDK6, ANGPT2
30glucose449.4CYP27B1, GFAP, HSPB2, NES, ANGPT2, CDK4
31egcg449.4CDK6, CDK4, EGFR
32pd 98,059449.4GFAP, HSPB2, FOSL1, CDK4, EGFR
33herbimycin a44 6110.3CDK6, CDK4, EGFR
34ly294002449.3ANGPT2, CDK6, CDK4, EGFR
35cyclic amp44 2410.2CDK4, FOSL1, GFAP, CYP27B1
36nitric oxide44 24 1111.1NES, FIGF, ANGPT2, FOSL1, CDK4
37cisplatin44 50 61 1112.0GFAP, HSPB2, CDK6, CDK4, EGFR
38thymidine44 249.8CDK4, CDK6, ANGPT2, FLT3LG, GFAP
39retinoic acid44 249.3CYP27B1, GFAP, NES, ANGPT2, FOSL1, CDK6
40vegf448.3GFAP, HSPB2, FLT3LG, NES, FIGF, ANGPT2
41serine448.3GFAP, HSPB2, ANGPT2, FOSL1, CDK6, CDK4
42oxygen44 249.1CYP27B1, GFAP, HSPB2, NES, FIGF, ANGPT2
43calcium44 50 24 1111.0CYP27B1, GFAP, HSPB2, CLDN5, ANGPT2, FOSL1
44estrogen447.8CYP27B1, GFAP, NES, FIGF, ANGPT2, FOSL1
45tyrosine446.8EGFR, CYP27B1, GFAP, HSPB2, FLT3LG, NES

GO Terms for genes affiliated with Glioblastoma Multiforme

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Cellular components related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.4CDK4, CDK6
2extracellular spaceGO:0056158.1EGFR, IL13RA2, ANGPT2, FIGF, FLT3LG, TNFSF13

Biological processes related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1astrocyte developmentGO:0140029.4CDK6, GFAP
2positive regulation of fibroblast proliferationGO:0481469.1CDK6, CDK4, EGFR
3signal transductionGO:0071658.4EGFR, CDK4, IL13RA2, ANGPT2, FLT3LG, TNFSF13
4positive regulation of cell proliferationGO:0082848.2EGFR, CDK4, FOSL1, FIGF, FLT3LG, TNFSF13

Molecular functions related to Glioblastoma Multiforme according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:0309719.7ANGPT2, FLT3LG
2cyclin bindingGO:0303329.1CDK4, CDK6

Products for genes affiliated with Glioblastoma Multiforme

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Sources for Glioblastoma Multiforme

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet