MCID: GLB012
MIFTS: 16

Glioblastoma Proneural Subtype

Categories: Cancer diseases

Aliases & Classifications for Glioblastoma Proneural Subtype

MalaCards integrated aliases for Glioblastoma Proneural Subtype:

Name: Glioblastoma Proneural Subtype 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0050804

Summaries for Glioblastoma Proneural Subtype

Disease Ontology : 12 A glioblastoma multiforme that is characterized by IDH1 and p53 mutations and Platelet Derived Growth Factor A amplification.

MalaCards based summary : Glioblastoma Proneural Subtype is related to unilateral retinoblastoma and pharynx cancer. An important gene associated with Glioblastoma Proneural Subtype is ALDH1A3 (Aldehyde Dehydrogenase 1 Family Member A3), and among its related pathways/superpathways are DNA Damage and WNT Signaling. Related phenotypes are Decreased substrate adherent cell growth and embryo

Related Diseases for Glioblastoma Proneural Subtype

Diseases related to Glioblastoma Proneural Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 unilateral retinoblastoma 9.7 CDK4 CDK6
2 pharynx cancer 9.7 CDK4 CDK6
3 post-surgical hypoinsulinemia 9.6 CDK4 CDK6
4 dubin-johnson syndrome 9.6 CDK4 CDK6
5 small cell sarcoma 9.5 CDK4 CDK6
6 osteosarcoma, somatic 9.5 CDK4 CDK6
7 glomus vagale tumor 9.4 CDK4 CDK6
8 giant cell glioblastoma 9.2 CDK4 CDK6
9 glioblastoma neural subtype 9.1 ALDH1A3 CDK4 CDK6

Graphical network of the top 20 diseases related to Glioblastoma Proneural Subtype:



Diseases related to Glioblastoma Proneural Subtype

Symptoms & Phenotypes for Glioblastoma Proneural Subtype

GenomeRNAi Phenotypes related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.02 CDK6
2 Decreased substrate adherent cell growth GR00193-A-2 9.02 CDK4 CDK6
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 CDK4
4 Decreased substrate adherent cell growth GR00193-A-4 9.02 CDK4

MGI Mouse Phenotypes related to Glioblastoma Proneural Subtype:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.8 ALDH1A3 CDK4 CDK6

Drugs & Therapeutics for Glioblastoma Proneural Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Proneural Subtype

Genetic Tests for Glioblastoma Proneural Subtype

Anatomical Context for Glioblastoma Proneural Subtype

Publications for Glioblastoma Proneural Subtype

Variations for Glioblastoma Proneural Subtype

Expression for Glioblastoma Proneural Subtype

Search GEO for disease gene expression data for Glioblastoma Proneural Subtype.

Pathways for Glioblastoma Proneural Subtype

Pathways related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1 12.01 CDK4 CDK6
2 11.93 CDK4 CDK6
3
Show member pathways
11.93 CDK4 CDK6
4
Show member pathways
11.87 CDK4 CDK6
5 11.85 CDK4 CDK6
6
Show member pathways
11.83 CDK4 CDK6
7 11.76 CDK4 CDK6
8
Show member pathways
11.68 CDK4 CDK6
9 11.45 CDK4 CDK6
10 11.29 CDK4 CDK6
11 11.27 CDK4 CDK6
12
Show member pathways
11.19 CDK4 CDK6
13 10.79 CDK4 CDK6
14 10.46 CDK4 CDK6
15 10.13 CDK4 CDK6

GO Terms for Glioblastoma Proneural Subtype

Cellular components related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CDK4 CDK6

Biological processes related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.32 CDK4 CDK6
2 regulation of gene expression GO:0010468 9.26 CDK4 CDK6
3 G1/S transition of mitotic cell cycle GO:0000082 9.16 CDK4 CDK6
4 positive regulation of fibroblast proliferation GO:0048146 8.96 CDK4 CDK6
5 cellular response to phorbol 13-acetate 12-myristate GO:1904628 8.62 CDK4 CDK6

Molecular functions related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase activity GO:0004693 8.96 CDK4 CDK6
2 cyclin binding GO:0030332 8.62 CDK4 CDK6

Sources for Glioblastoma Proneural Subtype

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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