MCID: GLB012
MIFTS: 18

Glioblastoma Proneural Subtype

Categories: Cancer diseases

Aliases & Classifications for Glioblastoma Proneural Subtype

MalaCards integrated aliases for Glioblastoma Proneural Subtype:

Name: Glioblastoma Proneural Subtype 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0050804

Summaries for Glioblastoma Proneural Subtype

Disease Ontology : 12 A glioblastoma multiforme that is characterized by IDH1 and p53 mutations and Platelet Derived Growth Factor A amplification.

MalaCards based summary : Glioblastoma Proneural Subtype is related to retinal cancer and sensory system cancer. An important gene associated with Glioblastoma Proneural Subtype is ALDH1A3 (Aldehyde Dehydrogenase 1 Family Member A3), and among its related pathways/superpathways are DNA Damage and WNT Signaling. Related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Glioblastoma Proneural Subtype

Diseases related to Glioblastoma Proneural Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 retinal cancer 9.8 CDK4 CDK6
2 sensory system cancer 9.7 CDK4 CDK6
3 ocular cancer 9.7 CDK4 CDK6
4 nervous system cancer 9.7 CDK4 CDK6
5 melanoma, cutaneous malignant 1 9.7 CDK4 CDK6
6 glioma 9.7 CDK4 CDK6
7 squamous cell carcinoma, head and neck 9.6 CDK4 CDK6
8 retinoblastoma 9.6 CDK4 CDK6
9 glioblastoma multiforme 9.5 CDK4 CDK6
10 glioblastoma 9.4 CDK4 CDK6

Graphical network of the top 20 diseases related to Glioblastoma Proneural Subtype:



Diseases related to Glioblastoma Proneural Subtype

Symptoms & Phenotypes for Glioblastoma Proneural Subtype

GenomeRNAi Phenotypes related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.02 CDK6
2 Decreased substrate adherent cell growth GR00193-A-2 9.02 CDK4 CDK6
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 CDK4
4 Decreased substrate adherent cell growth GR00193-A-4 9.02 CDK4

MGI Mouse Phenotypes related to Glioblastoma Proneural Subtype:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.8 ALDH1A3 CDK4 CDK6

Drugs & Therapeutics for Glioblastoma Proneural Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Proneural Subtype

Genetic Tests for Glioblastoma Proneural Subtype

Anatomical Context for Glioblastoma Proneural Subtype

Publications for Glioblastoma Proneural Subtype

Variations for Glioblastoma Proneural Subtype

Expression for Glioblastoma Proneural Subtype

Search GEO for disease gene expression data for Glioblastoma Proneural Subtype.

Pathways for Glioblastoma Proneural Subtype

Pathways related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 12.04 CDK4 CDK6
2 11.96 CDK4 CDK6
3
Show member pathways
11.95 CDK4 CDK6
4
Show member pathways
11.9 CDK4 CDK6
5 11.88 CDK4 CDK6
6
Show member pathways
11.86 CDK4 CDK6
7 11.8 CDK4 CDK6
8
Show member pathways
11.72 CDK4 CDK6
9 11.66 CDK4 CDK6
10
Show member pathways
11.62 CDK4 CDK6
11 11.45 CDK4 CDK6
12 11.34 CDK4 CDK6
13 11.27 CDK4 CDK6
14
Show member pathways
11.19 CDK4 CDK6
15 10.79 CDK4 CDK6
16 10.46 CDK4 CDK6
17 10.13 CDK4 CDK6

GO Terms for Glioblastoma Proneural Subtype

Cellular components related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CDK4 CDK6

Biological processes related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.32 CDK4 CDK6
2 regulation of gene expression GO:0010468 9.26 CDK4 CDK6
3 G1/S transition of mitotic cell cycle GO:0000082 9.16 CDK4 CDK6
4 positive regulation of fibroblast proliferation GO:0048146 8.96 CDK4 CDK6
5 cellular response to phorbol 13-acetate 12-myristate GO:1904628 8.62 CDK4 CDK6

Molecular functions related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase activity GO:0004693 8.96 CDK4 CDK6
2 cyclin binding GO:0030332 8.62 CDK4 CDK6

Sources for Glioblastoma Proneural Subtype

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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