MCID: GLB008
MIFTS: 20

Glioblastoma, Somatic malady

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Summaries for Glioblastoma, Somatic

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MalaCards based summary: Glioblastoma, Somatic is related to glioblastoma and neuroblastoma. An important gene associated with Glioblastoma, Somatic is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are ErbB4 Pathway and Pathways in cancer. The compounds taxane and radicicol have been mentioned in the context of this disorder.

Description from OMIM:46 137800

Aliases & Classifications for Glioblastoma, Somatic

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Glioblastoma, Somatic, Aliases & Descriptions:

Name: Glioblastoma, Somatic 46


Related Diseases for Glioblastoma, Somatic

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Graphical network of the top 20 diseases related to Glioblastoma, Somatic:



Diseases related to glioblastoma, somatic

Symptoms for Glioblastoma, Somatic

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Clinical features from OMIM:

137800

Drugs & Therapeutics for Glioblastoma, Somatic

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Drug clinical trials:

Search ClinicalTrials for Glioblastoma, Somatic

Search NIH Clinical Center for Glioblastoma, Somatic

Genetic Tests for Glioblastoma, Somatic

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Anatomical Context for Glioblastoma, Somatic

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Animal Models for Glioblastoma, Somatic or affiliated genes

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Publications for Glioblastoma, Somatic

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Variations for Glioblastoma, Somatic

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Clinvar genetic disease variations for Glioblastoma, Somatic:

6
id Gene Name Type Significance SNP ID Assembly Location
1ERBB2NM_001005862.2(ERBB2): c.2650G> A (p.Glu884Lys)single nucleotide variantPathogenicrs28933368GRCh37Chr 17, 37881974: 37881974
2TP53NM_000546.5(TP53): c.542G> T (p.Arg181Leu)single nucleotide variantrisk factorrs397514495GRCh37Chr 17, 7578388: 7578388

Expression for genes affiliated with Glioblastoma, Somatic

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Expression patterns in normal tissues for genes affiliated with Glioblastoma, Somatic

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Pathways for genes affiliated with Glioblastoma, Somatic

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Pathways related to Glioblastoma, Somatic according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ERBB2, TP53
29.1TP53, ERBB2
39.1ERBB2, TP53
49.1ERBB2, TP53
5
Show member pathways
9.1TP53, ERBB2
6
Show member pathways
9.1ERBB2, TP53
7
Show member pathways
9.1ERBB2, TP53
8
Show member pathways
9.1ERBB2, TP53
9
Show member pathways
9.1ERBB2, TP53
10
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.1TP53, ERBB2
119.1ERBB2, TP53
12
Show member pathways
9.1ERBB2, TP53
13
Show member pathways
9.1TP53, ERBB2
149.1ERBB2, TP53
15
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.1ERBB2, TP53
16
Show member pathways
Signal transduction PTEN pathway60
9.1TP53, ERBB2
17
Show member pathways
Signaling Pathways in Glioblastoma37
9.1TP53, ERBB2
18
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.1ERBB2, TP53
19
Show member pathways
9.1ERBB2, TP53
209.1ERBB2, TP53

Compounds for genes affiliated with Glioblastoma, Somatic

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Compounds related to Glioblastoma, Somatic according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1taxane449.5ERBB2, TP53
2radicicol44 61 1111.5ERBB2, TP53
3suberoylanilide hydroxamic acid449.5ERBB2, TP53
4n-(4-hydroxyphenyl)retinamide449.5ERBB2, TP53
5oxaliplatin44 50 1111.5TP53, ERBB2
6flavopiridol44 1110.5ERBB2, TP53
7bortezomib44 50 1111.5ERBB2, TP53
8irinotecan44 50 1111.5ERBB2, TP53
9carboplatin44 50 1111.5TP53, ERBB2
10geldanamycin44 50 61 1112.5ERBB2, TP53
11gemcitabine44 50 1111.5ERBB2, TP53
12thymidylate449.5ERBB2, TP53
13resveratrol44 61 24 1112.5TP53, ERBB2
14adriamycin449.5ERBB2, TP53
15docetaxel44 50 61 1112.5ERBB2, TP53
16egcg449.5ERBB2, TP53
17cyclophosphamide44 50 1111.4TP53, ERBB2
18curcumin449.4ERBB2, TP53
19guanine44 24 1111.4ERBB2, TP53
205fluorouracil449.4ERBB2, TP53
21etoposide44 50 61 1112.4TP53, ERBB2
22n acetylcysteine449.4ERBB2, TP53
23tamoxifen44 50 28 1112.4ERBB2, TP53
24paclitaxel44 50 1111.4ERBB2, TP53
25ly294002449.3TP53, ERBB2
26doxorubicin44 50 1111.3ERBB2, TP53
27paraffin449.3ERBB2, TP53
28cisplatin44 50 61 1112.2ERBB2, TP53
29cycloheximide449.2TP53, ERBB2
30progesterone44 28 61 24 1113.1ERBB2, TP53
31arginine449.1ERBB2, TP53
32h2o2449.0ERBB2, TP53
33vegf448.8ERBB2, TP53

GO Terms for genes affiliated with Glioblastoma, Somatic

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Biological processes related to Glioblastoma, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell proliferationGO:0082839.1ERBB2, TP53

Molecular functions related to Glioblastoma, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1ERBB2, TP53
2protein phosphatase bindingGO:0199039.0ERBB2, TP53
3protein heterodimerization activityGO:0469828.8ERBB2, TP53

Products for genes affiliated with Glioblastoma, Somatic

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Sources for Glioblastoma, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet