MCID: GLM040
MIFTS: 45

Glioma Susceptibility 1 malady

Categories: Genetic diseases (common), Neuronal diseases

Aliases & Classifications for Glioma Susceptibility 1

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Aliases & Descriptions for Glioma Susceptibility 1:

Name: Glioma Susceptibility 1 49 24
Glioblastoma Multiforme 67 65
Glioblastoma, Somatic 49 11
Oligodendroglioma 67 65
Astrocytoma 67 65
Glioma 67 65
Well Differentiated Oligodendroglioma 65
Glioma, Susceptibility to, Somatic 22
Glioma, Susceptibility to Somatic 22
 
Anaplastic Oligodendroglioma 65
Glioma of Brain, Familial 65
Familial Glioma of Brain 67
Glioma Somatic 49
Glioblastoma 65
Glioma 1 67
Glm1 67
Glm 67
Gbm 67

Characteristics:

HPO:

61
glioma susceptibility 1:
Inheritance: somatic mutation, autosomal dominant inheritance


Classifications:



External Ids:

OMIM49 137800
MeSH36 D005910
UMLS65 C0017638, C1621958, C1842010 C0334590, C0751396, more

Summaries for Glioma Susceptibility 1

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OMIM:49 Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma... (137800) more...

MalaCards based summary: Glioma Susceptibility 1, also known as glioblastoma multiforme, is related to spinal cord oligodendroglioma and brain oligodendroglioma, and has symptoms including glioblastoma, glioblastoma multiforme and ependymoma. An important gene associated with Glioma Susceptibility 1 is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are EGFR Signaling Pathway and Bladder cancer. The drugs cisplatin and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are respiratory system and muscle.

UniProtKB/Swiss-Prot:67 Glioma: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.

Related Diseases for Glioma Susceptibility 1

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Diseases in the Glioma Susceptibility 1 family:

Glioma Susceptibility 8 Glioma Susceptibility 9
Glioma Susceptibility 7 Glioma Susceptibility 5
Glioma Susceptibility 2 Glioma Susceptibility 4
Glioma Susceptibility 6

Diseases related to Glioma Susceptibility 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 557)
idRelated DiseaseScoreTop Affiliating Genes
1spinal cord oligodendroglioma33.9GFAP, IDH1
2brain oligodendroglioma33.6IDH1, IDH2
3childhood oligodendroglioma32.7GFAP, IDH1, IDH2, TP53
4giant cell glioblastoma30.7GFAP, IDH1, TP53
5syphilis30.2GFAP, TP53
6glioma29.5ERBB2, IDH1, IDH2, TP53
7astrocytoma29.4ERBB2, GFAP, IDH1, TP53
8glioblastoma multiforme12.9
9oligodendroglioma12.7
10brain glioblastoma multiforme12.7
11adult spinal cord glioblastoma multiforme12.6
12optic nerve glioma12.5
13adult oligodendroglioma12.4
14corpus callosum oligodendroglioma12.4
15anaplastic oligodendroglioma12.4
16mixed oligodendroglioma-astrocytoma12.3
17mixed astrocytoma-ependymoma-oligodendroglioma12.3
18glioblastoma12.1
19goodpasture syndrome11.7
20oligoastrocytoma11.6
21mismatch repair cancer syndrome10.5
22glioma susceptibility 910.5
23glioma susceptibility 210.5
24glioblastoma 310.5
25glioblastoma classical subtype10.5
26glioblastoma proneural subtype10.5
27glioblastoma mesenchymal subtype10.5
28glioblastoma neural subtype10.5
29gliomatosis cerebri10.5
30hepatitis10.5
31leukemia10.4
32lymphoma10.4
33prostatitis10.4
34breast cancer10.3
35endotheliitis10.3
36thyroiditis10.3
37pancreatic serous cystadenocarcinoma10.3ERBB2, TP53
38lung cancer10.3
39sarcoma10.3
40neuronitis10.3
41neuropathy10.3
42high molecular weight kininogen deficiency10.3ERBB2, TP53
43ovarian mesodermal adenosarcoma10.3ERBB2, TP53
44microglandular adenosis10.3ERBB2, TP53
45renal artery obstruction10.3ERBB2, TP53
46exposure keratitis10.3ERBB2, TP53
47endometrial mucinous adenocarcinoma10.3ERBB2, TP53
48hypogonadotropic hypogonadism-frontoparietal alopecia syndrome10.3IDH1, TP53
49pilocytic astrocytoma10.3IDH1, TP53
50basophilic carcinoma10.3ERBB2, TP53

Graphical network of the top 20 diseases related to Glioma Susceptibility 1:



Diseases related to glioma susceptibility 1

Symptoms for Glioma Susceptibility 1

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Symptoms by clinical synopsis from OMIM:

137800

Clinical features from OMIM:

137800

HPO human phenotypes related to Glioma Susceptibility 1:

id Description Frequency HPO Source Accession
1 glioblastoma HP:0100843
2 glioblastoma multiforme HP:0012174
3 ependymoma HP:0002888

Drugs & Therapeutics for Glioma Susceptibility 1

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Drugs for Glioma Susceptibility 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Temozolomideapproved, investigationalPhase 3, Phase 266285622-93-15394
Synonyms:
3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide
3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-as-tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide
3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
8-Carbamoyl-3-methylimidazo(5,1-D)-1,2,3,5-tetrazin-4(3H)-one
8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
85622-93-1
AC-758
AC1L1K9B
BIDD:GT0204
BRN 5547136
Bio-0147
C047246
C6H6N6O2
CCRG 81045
CCRG-81045
CCRIS 8996
CHEBI:153686
CHEMBL810
CID5394
CPD000466338
D06067
DB00853
Essex brand of temozolomide
HMS2051O12
HMS2090B08
I06-0149
I14-1943
LS-80558
M B 39831
M & B 39831
M&B 39831
M&B-39831
 
M-39831
MB 39831
MLS000759447
MLS001424028
MLS002701861
Methazolastone
NCGC00167429-01
NCGC00167429-02
NCI60_003316
NSC 362856
NSC-362856
NSC362856
SAM001246636
SMR000466338
STK623541
Sch 52365
Sch-52365
Schering brand of temozolomide
Schering-Plough brand of temozolomide
TL8005593
TMZ
TMZ-Bioshuttle
Temodal
Temodal (TN)
Temodar
Temozolamide
Temozolodida
Temozolodida [Spanish]
Temozolomid
Temozolomida
Temozolomide
Temozolomide (JAN/USAN/INN)
Temozolomide [INN:BAN]
Temozolomidum
Temozolomidum [Latin]
Témozolomide
UNII-YF1K15M17Y
ZINC01482184
m & b 39831
temozolomide
2
Dacarbazineapproved, investigationalPhase 3, Phase 24114342-03-45351166
Synonyms:
(5E)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide
(5Z)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide
(Dimethyltriazeno)imidazolecarboxamide
37626-23-6
4(5)-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
4(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide
4-(3,3-Dimethyltriazeno)imidazole-5-carboxamide
4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
4-(Dimethyltriazeno)imidazole-5-c arboxamide
4-(Dimethyltriazeno)imidazole-5-carboxamide
4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide
4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide
4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide
4-[3,3-dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide
4342-03-4
5(or 4)-(dimethyltriazeno)imidazol e-4(or 5)-carboxamide
5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide
5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
5-(3,3-Dimethyltri azeno)imidazole-4-carboxamide
5-(3,3-Dimethyltriazeno)-imidazole-4-carbamide
5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
5-(Dimethyltriazeno)-4-imidazolecarboxamide
5-(Dimethyltriazeno)imidazole-4-carboxamide
5-(Dimethyltriazeno)imidazole-4-carboximide
5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide
5-[3,3-Dimethyl-1-triazenyl]imidazole-4-carboxamide
94361-71-4
AC1NQXVV
AC1NS01W
AC1NS4BN
AI3-52825
BPBio1_000428
BRD-K35520305-001-07-8
BSPBio_000388
BSPBio_002091
Biocarbazin
Biocarbazine
Biocarbazine R
C6H10N6O
CAS-891986
CCRIS 190
CHEBI:4305
CHEMBL476
CID5281007
CID5351166
CID5353562
Carboxamide, Dimethyl Imidazole
D00288
D003606
D2390_SIGMA
D3634
DB00851
DIC
DTCI
DTIC
DTIC Dome
DTIC, DTIC-Dome, Dacarbazine
DTIC-Dome
DTICDome
DTIE
Dacarbazin
Dacarbazina
Dacarbazine
Dacarbazine (JAN/USP/INN)
Dacarbazine [USAN:INN:BAN:JAN]
Dacarbazino
Dacarbazino [INN-Spanish]
Dacarbazinum
Dacarbazinum [INN-Latin]
 
Dacatic
Decarbazine
Deticene
Di-me-triazenoimidazolecarboxamide
Di-methyl-triazenoimidazolecarboxamide
Dimethyl Imidazole Carboxamide
Dimethyl Triazeno Imidazole Carboxamide
Dimethyltriazenoimidazolecarboxamide
DivK1c_000326
Dtic-Dome
Dtic-Dome (TN)
Dtic-dome (tn)
EINECS 224-396-1
HE1150000
HMS1569D10
HMS2090A20
HMS2091I20
HMS501A08
HSDB 3219
I06-2280
I14-1659
ICDMT
ICDT
IDI1_000326
Imidazole Carboxamide
Imidazole Carboxamide, Dimethyl
Imidazole carboxamide
KBio1_000326
KBio2_001364
KBio2_003932
KBio2_006500
KBio3_001311
KBioGR_000896
KBioSS_001364
LS-119
MLS001332543
MLS001332544
MolPort-003-666-153
MolPort-003-846-120
MolPort-006-709-420
NCGC00016986-01
NCGC00091861-01
NCGC00091861-02
NCGC00091861-03
NCGC00091861-04
NCI-C04717
NCI60_004053
NCIMech_000261
NINDS_000326
NIOSH/HE1150000
NPFAPI-05
NSC 45388
NSC-45388
NSC45388
Prestwick0_000574
Prestwick1_000574
Prestwick2_000574
Prestwick3_000574
Prestwick_904
S1221_Selleck
SMP2_000251
SMR000857131
SPBio_001075
SPBio_002607
SPECTRUM1500218
ST51014976
Spectrum2_001148
Spectrum3_000366
Spectrum4_000308
Spectrum5_000823
Spectrum_000884
UNII-7GR28W0FJI
WLN: T5M CNJ DVZ ENUNN1&1
dacarbazine
3
Bevacizumabapproved, investigationalPhase 31875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
4Alkylating AgentsPhase 3, Phase 23582
5Antineoplastic Agents, AlkylatingPhase 3, Phase 23406
6lenograstimPhase 31134
7Immunologic FactorsPhase 318483
8Adjuvants, ImmunologicPhase 31783
9Immunoglobulin GPhase 3146
10MitogensPhase 31386
11ImmunoglobulinsPhase 34477
12Endothelial Growth FactorsPhase 3328
13Angiogenesis InhibitorsPhase 33688
14AntibodiesPhase 34477
15Angiogenesis Modulating AgentsPhase 33611
16Antibodies, MonoclonalPhase 32413
17
DisulfiramapprovedPhase 23497-77-83117
Synonyms:
1,1'-dithiobis(N,N-diethylthioformamide)
11078-22-1
155-01-1
86720_ALDRICH
86720_FLUKA
97-77-8
AB00051976
AC1L1F7H
AC1Q2YXI
AI3-27340
AKOS000120201
ARONIS24121
Abstenisil
Abstensil
Abstinil
Abstinyl
Accel TET
Accel TET-R
Accel Tet
Accel Tet-R
Akrochem TETD
Akrochem Tetd
Alcophobin
Alk-Aubs
Alk-aubs
Ancazide ET
Ancazide Et
Antab use
Antabus
Antabuse
Antabuse (TN)
Antabuse (tn)
Antadix
Antaenyl
Antaethan
Antaethyl
Antaetil
Antalcol
Antetan
Antethyl
Antetil
Anteyl
Anthethyl
Anti-Ethyl
Anti-ethyl
Antiaethan
Anticol
Antietanol
Antiethanol
Antietil
Antikol
Antivitium
Antivitium (Spain)
Aversan
Averzan
B0479
BPBio1_000060
BSPBio_000054
BSPBio_001930
Bis(diethylthiocarbamoyl) disulfide
Bonibal
C01692
C10H20N2S4
CAS-97-77-8
CCRIS 582
CHEBI:4659
CHEMBL964
CID3117
CPD000059171
Contralin
Contrapot
Cronetal
D00131
D004221
DB00822
Dicupral
Disetil
Disulfan
Disulfiram
Disulfirame
Disulfirame [DCIT]
Disulfiramo
Disulfiramum
Disulfirm
Disulfram
Disulfuram
Disulphuram
Dupon 4472
Dupont Fungicide 4472
EINECS 202-607-8
ENT 27,340
EU-0101164
Ekagom DTET
Ekagom Dtet
Ekagom TEDS
Ekagom TETDS
Ekagom Teds
Ekagom Tetds
Ekaland TETD
Ekaland Tetd
Ephorran
Espenal
Esperal
Esperal [France]
Eta bus
Etabus
Ethyl Thiram
Ethyl Thiudad
Ethyl Thiurad
Ethyl Tuads
Ethyl Tuads Rodform
Ethyl Tuex
Ethyl tuads
Ethyldithiourame
Ethyldithiurame
Etyl Tuex
Exhoran
Exhorran
Gababentin
HMS1568C16
HMS1920I16
HMS2051M17
 
HMS2090C18
HMS2091O22
HSDB 3317
Hoca
KBio2_001490
KBio2_004058
KBio2_006626
KBio3_001150
KBioGR_000895
KBioSS_001490
Krotenal
LS-2031
Lopac-T-1132
Lopac0_001164
MLS000069818
MLS000758264
MLS001076475
MolPort-001-792-519
N,N,N',N'-tetraethylthiuram disulfide
NCGC00016000-01
NCGC00016000-02
NCGC00016000-03
NCGC00016000-09
NCGC00094423-01
NCGC00094423-02
NCGC00094423-03
NCGC00094423-05
NCGC00094423-06
NCGC00094423-07
NCI-C02959
NSC 190940
NSC 25953
NSC-25953
NSC25953
Nocbin
Nocceler
Nocceler TET
Nocceler TET-G
Nocceler Tet
Nocceler Tet-G
Noxal
Noxal (VAN)
Perkacit TETD
Perkacit Tetd
Perkait TETD
Perkait Tetd
Prestwick0_000097
Prestwick1_000097
Prestwick2_000097
Prestwick3_000097
Prestwick_182
Refusal
Ro-Sulfiram
Ro-Sulfram-500 (USA)
Ro-sulfiram
Robac TET
S00294
S1680_Selleck
SAM001247028
SBB058706
SMR000059171
SPBio_001191
SPBio_001993
SPECTRUM1500262
STL069539
Sanceler TET
Sanceler TET-G
Sanceler Tet
Sanceler Tet-G
Soxinol TET
Soxinol Tet
Spectrum2_001176
Spectrum3_000405
Spectrum4_000228
Spectrum5_001590
Spectrum_001010
Stopaethyl
Stopethyl
Stopety
Stopetyl
Super Rodiatox
T 1132
T1132_SIGMA
TATD
TETD
THIOCID
TTD
TTS
TTS X
TTS x
Tenurid
Tenutex
Tetidis
Tetradin
Tetradine
Tetraethylthioperoxydicarbonic Diamide
Tetraethylthiram Disulfide
Tetraethylthiram Disulphide
Tetraethylthiuram
Tetraethylthiuram Disulfide
Tetraethylthiuram Disulphide
Tetraethylthiuram Sulfide
Tetraethylthiuran Disulfide
Tetraetil
Teturam
Teturamin
Thiocid
Thiophos
Thioscabin
Thireranide
Thiuram E
Thiuranide
Tillram
Tiuram
Tuads, ethyl
UNII-TR3MLJ1UAI
UPCMLD-DP090
UPCMLD-DP090:001
Usaf B-33
WLN: 2N2 & YUS & S 2
ZINC01529266
disulfiram
nchembio.559-comp2
tet raethylthiuram
18MicronutrientsPhase 23901
19Trace ElementsPhase 23900
20Phase 2
21
CopperPhase 21587440-50-827099
Synonyms:
 
Copper
Cu
22Protein Kinase InhibitorsPhase 23162
23
Erlotinib HydrochloridePhase 2781183319-69-9176871
Synonyms:
 
erlotinib hydrochloride
24
Vorinostatapproved, investigationalPhase 1238149647-78-95311
Synonyms:
149647-78-9
1zz1
AC-1923
AC1L1K2K
BRD-K81418486-001-10-3
C111237
CCRIS 8456
CHEBI:45716
CHEMBL98
CID5311
D06320
DB02546
EC-000.2057
FT-0082592
LS-186548
LS-186997
LS-187780
MK-0683
MK0683
MLS001065855
Merck brand of Vorinostat
MolPort-003-850-293
N'-hydroxy-N-phenyloctanediamide
N-Hydroxy-N'-phenyl octanediamide
N-Hydroxy-N'-phenyloctanediamide
N-Hyrdroxy-N'-phenyloctanediamide
N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide
N-hydroxy-N'-phenyloctanediamide
N1-hydroxy-N8-phenyloctanediamide
NCGC00168085-02
 
NHNPODA
NSC-701852
NSC701852
OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE
Octanedioic acid hydroxyamide phenylamide
S1047_Selleck
SAHA
SAHA cpd
SAHA, Suberoylanilide hydroxamic acid
SHH
SKI390
SMR000486344
SW-064652
Suberanilohydroxamic acid
SuberoylaN/Aide hydroxamic acid
Suberoylanilide hydroxamic acid
UNII-58IFB293JI
Vorinostat
Vorinostat (JAN/USAN)
Vorinostat MSD
Vorinostat [USAN]
Vorinostatum
WIN64652
ZINC01543873
Zolinza
Zolinza (TN)
Zolinza, MK-0683, SAHA
m344
nchembio.275-comp2
nchembio.313-comp1
nchembio815-comp18
suberoylanilide hydroxamic acid
25Histone Deacetylase InhibitorsPhase 1532
26
Doxorubicinapproved, investigationalPhase 0158223214-92-831703
Synonyms:
(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
(8S-cis)-10-((3-amino-2,3,6-Trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
111266-55-8
14-Hydroxydaunomycin
14-Hydroxydaunorubicine
14-hydroxydaunomycin
14-hydroxydaunorubicine
23214-92-8
23257-17-2
24385-08-8
25311-50-6
25316-40-9
25316-40-9 (hydrochloride)
29042-30-6
AC1L1M5T
AC1Q29OJ
ADM
ADR
Adriablastin
Adriacin (hydrochloride salt)
Adriamycin
Adriamycin PFS
Adriamycin PFS (hydrochloride salt)
Adriamycin RDF
Adriamycin RDF (hydrochloride salt)
Adriamycin Semiquinone
Adriamycin semiquinone
Adriblas tina
Adriblastin
Adriblastina
Adriblastina (TN)
Adriblastina (hydrochloride salt)
Aerosolized Doxorubicin
BPBio1_000502
BRD-K92093830-003-04-3
BSPBio_000456
BSPBio_001031
C01661
C27H29NO11
CCRIS 739
CHEBI:28748
CHEMBL179
CID31703
Caelyx
Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74
Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120
D03899
DB00997
DM2
DOX-SL
Doxil
Doxo
Doxorubicin
Doxorubicin (USAN/INN)
Doxorubicin HCl
 
Doxorubicin Hydrochloride
Doxorubicin [USAN:INN:BAN]
Doxorubicin citrate
Doxorubicin hydrochloride (hydrochloride salt)
Doxorubicin-P4/D10
Doxorubicin-P4/D10 conjugate
Doxorubicin-hLL1
Doxorubicin-hLL1 conjugate
Doxorubicina
Doxorubicina [INN-Spanish]
Doxorubicine
Doxorubicine [INN-French]
Doxorubicinum
Doxorubicinum [INN-Latin]
EINECS 245-495-6
FI 106
Farmablastina (hydrochloride salt)
HMS2089H06
HSDB 3070
Hydroxydaunomycin hydrochlor ide (hydrochloride salt)
Hydroxydaunomycin hydrochloride (hydrochloride salt)
Hydroxydaunorubicin
Hydroxydaunorubicin hydrochloride (hydrochloride salt)
JT9100000
LMPK13050001
LS-1029
LS-165655
MLS000759533
Myocet
NCI-C01514
NChemBio.2007.10-comp13
NDC 38242-874
NIOSH/JT9100000
NSC 123127
Prestwick0_000438
Prestwick1_000438
Prestwick2_000438
Prestwick3_000438
Probes1_000151
Probes2_000129
RDF Rubex
Resmycin
Rubex
Rubex (hydrochloride salt)
SMP1_000106
SPBio_002395
TLC D-99
ThermoDox
Triferric doxorubicin
UNII-80168379AG
adiblastine (hydrochloride salt)
adr iablatina (hydrochloride salt)
adriablastine (hydrochloride salt)
adriablatina (hydrochloride salt)
adriblatina (hydrochloride salt)
doxorubicin
nchembio809-comp5
27
EtoposideapprovedPhase 0116933419-42-036462
Synonyms:
(-)-Etoposide
121471-01-0
136598-18-0
201594-04-9
33419-42-0
35317-32-9
4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside
4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)
4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside)
4'-Demethylepipodophyllotoxin ethylidene-.beta.-D-glucoside
4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin
4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside
4-Demethylepipodophyllotoxin-.beta.-D-ethylideneglucoside
51854-34-3
76576-58-4
9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one
AB00438905
AC1L1FN8
AC1L1VT3
AC1L6246
AC1NR4OG
AC1O4WGG
AC1O7M1N
AC1Q47JJ
Ambap33419-42-0
BPBio1_000673
BRD-K37798499-001-02-5
BSPBio_000611
Bio1_000489
Bio1_000978
Bio1_001467
C01576
CCRIS 2392
CHEBI:4911
CHEBI:588795
CHEMBL44657
CID11758093
CID284997
CID3310
CID36462
CID5284558
CID6419930
CID6610299
CPD000112002
D00125
DB00773
DEMETHY-EPIPODOPHYLLOTOXIN,ETHYLIDENE GLUCOSIDE,
Demethyl Epipodophyllotoxin Ethylidine Glucoside
Demethyl-epiodophyllotoxin ethylidene glucoside
Demethylepipodophyllotoxin-beta-D-ethylideneglucoside
E0675
E1383_SIGMA
EINECS 251-509-1
EPE
EPEG
ETOP
Epipodophyllotoxin
Epipodophyllotoxin VP-16213
Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-.beta.-D-glucopyranoside
Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside
Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI)
Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-.beta.-D-glucopyranoside)
Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside)
Eposide
Eposin
Eposin, Vepesid, VP-16, Toposar, Etoposide
 
Etopol
Etopophos
Etopophos (phosphate salt)
Etoposid
Etoposide
Etoposide (JP15/USP/INN)
Etoposide (VP16)
Etoposide Phosphate
Etoposide [USAN:INN:BAN:JAN]
Etoposido
Etoposido [INN-Spanish]
Etoposidum
Etoposidum [INN-Latin]
Etosid
HMS1569O13
HMS2052N05
HMS2089F14
HSDB 6517
I06-0248
KBioSS_002410
LS-1214
Lastet
MLS000049957
MLS001074951
MLS001424283
MLS002153463
MLS002207239
MLS002222184
MolPort-003-983-431
MolPort-004-905-001
MolPort-004-955-161
NCGC00025056-02
NChemBio.2007.10-comp19
NK 171
NSC 141540
NSC-141540
NSC141540
Prestwick0_000396
Prestwick1_000396
Prestwick2_000396
Prestwick3_000396
Prestwick_211
S1225_Selleck
SAM001246880
SMR000112002
SPBio_002532
ST056353
Toposar
UNII-6PLQ3CP4P3
VP 16
VP 16 (pharmaceutical)
VP 16-213
VP 16213
VP-16
VP-16-213
VePESID (TN)
VePesid
Vepesid
Vepesid J
Vepeside
ZINC03830818
ZINC03938684
Zuyeyidal
etoposide
nchembio.573-comp8
nchembio873-comp2
trans-Etoposide
28Pembrolizumabapproved2881374853-91-4
29
DoxilApproved June 1999Phase 0158231703
Synonyms:
Dox-SL
Doxil
 
Evacet
LipoDox
Pegylated Liposomal Doxorubicin Hydrochloride
liposomal doxorubicin
30Pharmaceutical Solutions7004
31Ferrosoferric Oxide62
32Hematinics1121
33Parenteral Nutrition Solutions71
34Etoposide phosphatePhase 01169
35Topoisomerase InhibitorsPhase 04081
36Antineoplastic Agents, PhytogenicPhase 04294
37Anti-Bacterial AgentsPhase 09140
38Antibiotics, AntitubercularPhase 05971

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With CancerRecruitingNCT01987596Phase 3
2Temozolomide and Radiation Therapy With or Without Bevacizumab in Treating Patients With Newly Diagnosed GlioblastomaActive, not recruitingNCT00884741Phase 3
3Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory Pediatric Solid TumorsNot yet recruitingNCT02689336Phase 2
4Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma MultiformNot yet recruitingNCT01777919Phase 2
5Vandetanib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Diffuse Brainstem GliomaCompletedNCT00472017Phase 1
6High-Dose Vorinostat and Fractionated Stereotactic Body Radiation Therapy in Treating Patients With Recurrent GliomaTerminatedNCT01378481Phase 1
7MRI Study With Ferumoxytol in Assessing Early Response in Patients With Glioblastoma Multiforme Receiving Temozolomide and Radiation TherapyCompletedNCT00660543
8Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas or Diffuse Intrinsic Pontine GliomasRecruitingNCT02359565
9Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain TumorsRecruitingNCT02372409Phase 0
10Steady State Blood Volume Maps Using Ferumoxytol Non-stoichiometric Magnetite MRI in Imaging Patients With GlioblastomaRecruitingNCT02359097
11Ferumoxytol in Improving MR Imaging in Patients With High-Grade Brain Tumors or Cerebral MetastasesRecruitingNCT00103038
12Next Generation Sequencing of Tumor and Normal Tissues Prospectively in Pediatric Oncology Patients at St. Jude Children's Research HospitalRecruitingNCT02530658
13Gliogene: Brain Tumor Linkage StudyActive, not recruitingNCT00418899
14A Explore Study of Bevacizumab Combined With Conventional Therapy in GlioblastomaActive, not recruitingNCT01939574

Search NIH Clinical Center for Glioma Susceptibility 1

Inferred drug relations via UMLS65/NDF-RT43:

Genetic Tests for Glioma Susceptibility 1

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Genetic tests related to Glioma Susceptibility 1:

id Genetic test Affiliating Genes
1 Glioma, Susceptibility to Somatic22 IDH1

Anatomical Context for Glioma Susceptibility 1

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MalaCards organs/tissues related to Glioma Susceptibility 1:

33
Brain, Spinal cord, Bone, Bone marrow, Endothelial

Animal Models for Glioma Susceptibility 1 or affiliated genes

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MGI Mouse Phenotypes related to Glioma Susceptibility 1:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7ERBB2, IDH1, NEU1, TP53
2MP:00053698.4ERBB2, GFAP, NEU1, TP53
3MP:00053907.6ERBB2, IDH1, IDH2, NEU1, TP53
4MP:00053857.3ERBB2, GFAP, IDH2, NEU1, TP53

Publications for Glioma Susceptibility 1

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Variations for Glioma Susceptibility 1

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UniProtKB/Swiss-Prot genetic disease variations for Glioma Susceptibility 1:

67
id Symbol AA change Variation ID SNP ID
1IDH2p.Pro158LeuVAR_073181
2IDH2p.Pro162SerVAR_073182
3IDH2p.Arg172GlyVAR_073183
4IDH2p.Arg172LysVAR_073184
5IDH2p.Arg172MetVAR_073185

Clinvar genetic disease variations for Glioma Susceptibility 1:

5
id Gene Variation Type Significance SNP ID Assembly Location
1ERBB2NM_001005862.2(ERBB2): c.2650G> A (p.Glu884Lys)single nucleotide variantPathogenicrs28933368GRCh37Chr 17, 37881974: 37881974
2TP53NM_000546.5(TP53): c.542G> T (p.Arg181Leu)single nucleotide variantrisk factorrs397514495GRCh37Chr 17, 7578388: 7578388

Expression for genes affiliated with Glioma Susceptibility 1

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Search GEO for disease gene expression data for Glioma Susceptibility 1.

Pathways for genes affiliated with Glioma Susceptibility 1

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Pathways related to Glioma Susceptibility 1 according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5ERBB2, TP53
29.5ERBB2, TP53
39.2IDH1, IDH2
49.1ERBB2, IDH1, TP53

GO Terms for genes affiliated with Glioma Susceptibility 1

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Biological processes related to Glioma Susceptibility 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:00060999.2IDH1, IDH2

Sources for Glioma Susceptibility 1

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet