MCID: GLM004
MIFTS: 58

Gliomatosis Cerebri malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Gliomatosis Cerebri

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Sources:
44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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Fully expand this MalaCard

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NIH Rare Diseases:44 Gliomatosis cerebri is a type of brain cancer.Ā  it is a variant form of glioblastoma multiforme. it is characterized by scattered and widespread tumor cells that can cause the cerebrum, cerebellum, or brain stem to enlarge. signs and symptoms may include personality changes, memory disturbance, headache, hemiparesis, and seizures. Ā because this tumor is so diffuse it can be challenging to treat and the prognosis for people with gliomatosis cerebri is generally poor. last updated: 3/5/2009

MalaCards: Gliomatosis Cerebri, also known as astrocytosis cerebri, is related to pituitary adenoma and medulloblastoma. An important gene associated with Gliomatosis Cerebri is GFAP (glial fibrillary acidic protein), and among its related pathways are Alzheimers Disease Pathway and VEGF Signaling Pathway. The compounds fiin 1 hydrochloride and pd 161570 have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and spinal cord, and related mouse phenotypes are hearing/vestibular/ear and pigmentation.

Wikipedia:66 Gliomatosis cerebri (infiltrative diffuse astrocytosis) is a rare primary brain tumor. It is commonly... more...

Aliases & Classifications for Gliomatosis Cerebri

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 46Novoseek, 50Orphanet, 63UMLS, 36MeSH, 41NCIt, 59SNOMED-CT, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
gliomatosis cerebri:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

gliomatosis cerebri 9 44 46 50 63
astrocytosis cerebri 9


External Ids:

Disease Ontology9 DOID:6128
MeSH36 D018302
NCIt41 C4318
SNOMED-CT59 26138003
SNOMED-CT via Orphanet60 26138003
UMLS via Orphanet64 C0334576

Related Diseases for Gliomatosis Cerebri

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Gliomatosis Cerebri via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma30.3RB1, FGFR2, FGFR4
2medulloblastoma30.3GFAP, TP53, MAP2, FGFR2
3adenoma30.0TP53, RB1, CDKN1A, CDKN2A, CD44, FGFR4
4glioblastoma multiforme29.9FGFR1, FGFR4, FGFR2, CD44, IDH1, GFAP
5breast cancer29.8PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A
6astrocytoma29.6FGFR1, INA, IDH1, GFAP, PTEN, TP53
7dementia10.5
8encephalomyelitis10.4
9acute disseminated encephalomyelitis10.3
10cerebritis10.3
11encephalitis10.3
12hypertension10.3
13intracranial hypertension10.3
14neurofibromatosis10.2
15obsessive-compulsive disorder10.2
16neuronitis10.2
17scotoma10.2
18creutzfeldt-jakob disease10.2
19ollier disease10.2
20cervicitis10.2
21hodgkin's lymphoma10.2
22hydrocephalus10.2
23multiple sclerosis10.2
24limbic encephalitis10.2
25rasmussen encephalitis10.2
26epidermal nevus10.2
27headache10.2
28neurosarcoidosis10.2
29subependymal giant cell astrocytoma10.1GFAP
30achondroplasia10.1FGFR2
31intraductal papilloma10.1IDH1
32osteoglophonic dysplasia10.1FGFR1
33turcot syndrome10.1PTEN
34pineoblastoma10.1GFAP
35gliosarcoma10.1PTEN, GFAP
36antley-bixler syndrome10.1FGFR2
37gemistocytic astrocytoma10.1GFAP, PTEN
38actinic keratosis10.1TP53
39central neurocytoma10.1GFAP, MAP2
40fgfr-related craniosynostosis syndromes10.1FGFR2, FGFR1
41jackson-weiss syndrome10.1FGFR2, FGFR1
42muenke syndrome10.1FGFR1, FGFR2
43infectious mononucleosis10.1FGFR2, FGFR1
44crouzon syndrome10.1FGFR2, FGFR1
45hypochondroplasia10.1FGFR2, FGFR1
46pilocytic astrocytoma10.1IDH1, GFAP, PTEN
47acrocephalosyndactylia10.1FGFR2, FGFR1
48saethre-chotzen syndrome10.1FGFR2, FGFR1
49meningioma10.1FGFR2, PTEN, GFAP
50giant cell glioblastoma10.1GFAP, PTEN, MDM2

Graphical network of the top 20 diseases related to Gliomatosis Cerebri:



Diseases related to gliomatosis cerebri

Symptoms for Gliomatosis Cerebri

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Drugs & Therapeutics for Gliomatosis Cerebri

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gliomatosis Cerebri

Drug clinical trials:

Search ClinicalTrials for Gliomatosis Cerebri

Search NIH Clinical Center for Gliomatosis Cerebri

Search CenterWatch for Gliomatosis Cerebri

Genetic Tests for Gliomatosis Cerebri

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Anatomical Context for Gliomatosis Cerebri

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34MalaCards
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MalaCards organs/tissues related to Gliomatosis Cerebri:

34
Brain, Cerebellum, Spinal cord, Breast, Pituitary

Animal Models for Gliomatosis Cerebri or affiliated genes

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38MGI
See all sources

MGI Mouse Phenotypes related to Gliomatosis Cerebri:

38 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8FGFR1, FGFR2, CDKN1A, RB1
2MP:00011868.0PTEN, TP53, RB1, MDM2, CDKN2A, FGFR2
3MP:00053757.7PTEN, TP53, RB1, CDKN1A, FGFR2
4MP:00053827.5PTEN, TP53, RB1, MDM2, CDKN1A, FGFR2
5MP:00028737.3INA, GFAP, PTEN, TP53, RB1, MDM2
6MP:00053677.3PTEN, TP53, MDM2, CDKN1A, CD44, FGFR2
7MP:00053717.2PTEN, TP53, RB1, MDM2, CDKN1A, CD44
8MP:00053807.0PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A
9MP:00053887.0PTEN, TP53, RB1, CDKN1A, CDKN2A, CD44
10MP:00030127.0TP53, RB1, MDM2, CDKN1A, CDKN2A, FGFR2
11MP:00053707.0PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A
12MP:00053856.9GFAP, PTEN, TP53, RB1, MDM2, CDKN1A
13MP:00053916.9GFAP, PTEN, TP53, RB1, CDKN1A, CDKN2A
14MP:00020066.8PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A
15MP:00053796.7PTEN, TP53, MAP2, RB1, CDKN1A, CDKN2A
16MP:00053906.7PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A
17MP:00107716.7PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A
18MP:00053816.5FGFR1, GFAP, PTEN, TP53, RB1, MDM2
19MP:00053696.5GFAP, PTEN, TP53, RB1, MDM2, CDKN1A
20MP:00053976.5IDH1, PTEN, TP53, RB1, MDM2, CDKN1A
21MP:00053766.4IDH1, GFAP, PTEN, TP53, RB1, CDKN1A
22MP:00053896.4RB1, MAP2, TP53, PTEN, MDM2, CDKN1A
23MP:00053876.2TP53, PTEN, GFAP, IDH1, RB1, MDM2
24MP:00053846.2GFAP, PTEN, TP53, RB1, MDM2, CDKN1A
25MP:00053866.2GFAP, PTEN, TP53, MAP2, RB1, MDM2
26MP:00053785.9RB1, MAP2, TP53, PTEN, GFAP, MDM2
27MP:00107685.8RB1, MAP2, TP53, PTEN, GFAP, MDM2
28MP:00036315.7MAP2, TP53, PTEN, GFAP, INA, RB1

Publications for Gliomatosis Cerebri

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Sources:
53PubMed
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Articles related to Gliomatosis Cerebri:

(show top 50)    (show all 202)
idTitleAuthorsYear
1
18F FDG PET/CT in a child with gliomatosis cerebri. (23122744)
2013
2
Letter to the editor: gliomatosis cerebri. (23198839)
2013
3
Response: gliomatosis cerebri. (23495379)
2013
4
Bilateral ptosis as initial presentation of gliomatosis cerebri: case report. (23427031)
2013
5
Juvenile parkinsonism as an initial manifestation of gliomatosis cerebri. (24158273)
2013
6
Gliomatosis cerebri diagnostic challenge: two case reports. (21881469)
2011
7
Medulloblastoma and gliomatosis cerebri: rare brain tumors in multiple sclerosis patients. (21234776)
2011
8
NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebri. (21710625)
2011
9
Gliomatosis cerebri. (20530537)
2011
10
Gliomatosis cerebri presenting as idiopathic intracranial hypertension in a child. (21566531)
2011
11
Gliomatosis cerebri: report of 3 cases. (20809715)
2010
12
Multiple pilomatricomas and gliomatosis cerebri--a new association? (19250412)
2009
13
Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri. (18285534)
2008
14
Array-based comparative genomic hybridization and immunohistochemical studies in gliomatosis cerebri. (18704270)
2008
15
Gliomatosis cerebri: growing evidence for diffuse gliomas with wide invasion. (18416661)
2008
16
Evaluation of molecular genetic alterations associated with tumor progression in a case of gliomatosis cerebri. (16955219)
2007
17
Gliomatosis cerebri mimicking Rasmussen encephalitis. Case report. (18459886)
2007
18
1H MR spectroscopy in the assessment of gliomatosis cerebri. (17312058)
2007
19
Gliomatosis cerebri treatment in 11 elderly patients. (16918128)
2006
20
Gliomatosis cerebri and pituitary adenoma: case report and literature review. (16132522)
2005
21
Clinical diagnosis of gliomatosis cerebri: report of three cases. (15700839)
2004
22
Three-dimensional anisotropy contrast imaging of gliomatosis cerebri: two case reports. (15261511)
2004
23
Pseudo-subarachnoid hemorrhage and cortical visual impairment as the presenting sign of gliomatosis cerebri. (15590541)
2004
24
Gliomatosis cerebri in a young patient showing various cranial nerve manifestations: a case report. (14756448)
2003
25
Mitochondrial DNA as a clonal tumor cell marker: gliomatosis cerebri. (12587789)
2003
26
Dramatic response to chemotherapy in oligodendroglial gliomatosis cerebri. (12913224)
2003
27
Histological and MR correlations in Gliomatosis cerebri. (12241123)
2002
28
Dynamic contrast-enhanced T2*-weighted MR imaging of gliomatosis cerebri. (11900998)
2002
29
Gliomatosis cerebri. (11893895)
2002
30
Histological and genetic diagnosis of gliomatosis cerebri: case report. (11519853)
2001
31
Diagnosis and results of treatment with radiation therapy in gliomatosis cerebri patient: case report. (11355088)
2001
32
CT and MRI findings in gliomatosis cerebri: a neuroradiologic and neuropathologic review of diffuse infiltrating brain neoplasms. (11218033)
2001
33
Gliomatosis cerebri in a 10-year-old girl masquerading as diffuse encephalomyelitis and spinal cord tumour. (11221900)
2001
34
MRI diagnosis of gliomatosis cerebri. (10082346)
1999
35
Oligodendroglial gliomatosis cerebri: (1)H-MRS suggests elevated glycine/inositol levels. (10525765)
1999
36
Secondary glioblastoma remarkably reduced by steroid administration after anaplastic transformation from gliomatosis cerebri--case report. (10063361)
1998
37
Gliomatosis cerebri: a brain tumour which is too difficult to treat? (9682295)
1998
38
Gliomatosis cerebri: clinical, radiological and pathological report of a case with a stroke-like onset. (9008778)
1996
39
A difficult diagnosis of gliomatosis cerebri. (8837088)
1996
40
Gliomatosis cerebri or benign intracranial hypertension? (7644408)
1995
41
Neuroradiology case of the day. Gliomatosis cerebri. (7785606)
1995
42
Chromosomes in gliomatosis cerebri. (8527397)
1995
43
Gliomatosis cerebri at the 17-year-old girl--correlations of histological, CT and MRI appearance. (7889339)
1994
44
Gliomatosis cerebri: comparison of MR and CT features. (8372774)
1993
45
Gliomatosis cerebri: a case report with autopsy correlation. (1528447)
1992
46
Diagnosis and management of gliomatosis cerebri: recent trends. (1759182)
1991
47
Gliomatosis cerebri with formation of a glioblastoma multiform. Study and follow-up by magnetic resonance and computed tomography. (2848658)
1988
48
Magnetic resonance imaging determination of gliomatosis cerebri. (3822096)
1987
49
Gliomatosis cerebri. Report of four cases and review of the literature. (4499966)
1974
50
Gliomatosis cerebri. (14946583)
1952

Variations for Gliomatosis Cerebri

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Expression for genes affiliated with Gliomatosis Cerebri

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gliomatosis Cerebri

Search GEO for disease gene expression data for Gliomatosis Cerebri.

Pathways for genes affiliated with Gliomatosis Cerebri

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Sources:
51PathCards, 54QIAGEN, 52PharmGKB, 58SinoBiological, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 13EMD Millipore, 62Tocris Bioscience, 5Cell Signaling Technology, 55R&D Systems
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Pathways related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FGFR2, FGFR4, FGFR1
2
Show member pathways
9.3FGFR4, FGFR1, FGFR2, PTEN
3
Show member pathways
9.0CDKN1A, TP53
48.8PTEN, CDKN1A, MDM2, RB1
58.8TP53, MDM2, CDKN2A
6
Show member pathways
8.7TP53, MDM2, CDKN1A
7
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
8.6PTEN, TP53, RB1, MDM2
88.6PTEN, MDM2, RB1, TP53
9
Show member pathways
8.5CDKN2A, CDKN1A, MDM2, RB1
10
Show member pathways
8.5FGFR4, FGFR1, PTEN, TP53, FGFR2
11
Show member pathways
8.5FGFR4, CD44, CDKN1A, FGFR2, FGFR1
12
Show member pathways
Signal transduction PTEN pathway61
8.4TP53, MDM2, CDKN1A, PTEN
13
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
8.4TP53, PTEN, CDKN1A, MDM2
14
Show member pathways
8.4TP53, MDM2, FGFR2, FGFR1, FGFR4
158.3RB1, MDM2, CDKN2A, TP53
16
Show member pathways
8.3PTEN, MDM2, FGFR2, FGFR4, CDKN1A, FGFR1
17
Show member pathways
8.3MDM2, PTEN, FGFR4, CDKN1A, FGFR1, FGFR2
18
Show member pathways
8.3FGFR4, MDM2, PTEN, CDKN1A, FGFR1, FGFR2
198.2CDKN1A, MDM2, RB1, TP53
208.2TP53, RB1, CDKN1A, CD44
21
Show member pathways
8.1TP53, CDKN2A, MDM2, CDKN1A
22
Show member pathways
8.1PTEN, FGFR4, MDM2, FGFR2, TP53, FGFR1
238.1PTEN, TP53, FGFR1, MDM2, CDKN1A
24
Show member pathways
8.1TP53, CDKN2A, RB1, CDKN1A
25
Show member pathways
8.1FGFR1, FGFR2, GFAP, FGFR4, PTEN, MDM2
268.0PTEN, CDKN1A, MDM2, RB1, TP53
27
Show member pathways
8.0PTEN, RB1, TP53, MDM2, CDKN1A
287.9FGFR1, CD44, CDKN1A, TP53, MDM2
297.8CDKN1A, RB1, MDM2, TP53, CD44
30
Show member pathways
7.7TP53, CDKN1A, CDKN2A, MDM2, RB1
317.7CDKN2A, MDM2, RB1, TP53, CDKN1A
327.7CDKN2A, TP53, MDM2, RB1, CDKN1A
33
Show member pathways
Cell cycle39
7.7TP53, RB1, MDM2, CDKN1A, CDKN2A
34
Show member pathways
7.7TP53, CDKN1A, MDM2, RB1, CDKN2A
35
Show member pathways
7.7MDM2, CDKN1A, RB1, CDKN2A, TP53
367.6CDKN1A, MDM2, PTEN, IDH1, CD44, FGFR2
37
Show member pathways
7.5FGFR1, MDM2, FGFR4, CDKN1A, TP53, PTEN
387.5TP53, CDKN1A, PTEN, FGFR2, FGFR4, FGFR1
397.5FGFR2, FGFR1, CDKN1A, MDM2, TP53, PTEN
40
Show member pathways
DNA damage response39
7.5PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A
417.5PTEN, RB1, CDKN2A, CDKN1A, MDM2, TP53
427.4CD44, CDKN2A, PTEN, CDKN1A, MDM2, TP53
43
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
7.4CD44, PTEN, TP53, CDKN1A, CDKN2A, MDM2
44
Show member pathways
7.3PTEN, TP53, FGFR1, FGFR4, MDM2, FGFR2
457.0CDKN1A, MDM2, CD44, RB1, TP53, PTEN
46
Show member pathways
Signaling Pathways in Glioblastoma39
6.9CDKN2A, FGFR2, FGFR1, CDKN1A, MDM2, RB1
476.9FGFR1, FGFR2, CDKN1A, MDM2, RB1, TP53
48
Show member pathways
6.8RB1, CDKN1A, FGFR1, FGFR4, FGFR2, CDKN2A
49
Show member pathways
6.7MDM2, FGFR1, FGFR4, RB1, TP53, CDKN2A
50
Show member pathways
6.3FGFR1, FGFR4, FGFR2, RB1, TP53, GFAP

Compounds for genes affiliated with Gliomatosis Cerebri

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Sources:
62Tocris Bioscience, 46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB
See all sources

Compounds related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1fiin 1 hydrochloride629.7FGFR1, FGFR2, FGFR4
2pd 161570629.6FGFR1, FGFR4, FGFR2
3su 5402629.6FGFR2, FGFR4, FGFR1
4aflatoxin b146 259.6MDM2, CDKN2A, RB1, TP53
5hpvs468.4TP53, CDKN2A, RB1, CDKN1A
6olomoucine46 129.4TP53, RB1, CDKN1A, CDKN2A
7hmba468.3CDKN1A, CDKN2A, TP53, RB1
8pd 98,059468.3GFAP, PTEN, RB1, FGFR1, FGFR2, MDM2
9noxa468.3PTEN, CDKN1A, MDM2, TP53
10cyclophosphamide46 52 1210.2CD44, RB1, PTEN, TP53, MDM2, FGFR2
11bromodeoxyuridine468.2FGFR2, CD44, FGFR1, RB1, MAP2, GFAP
12cyclic amp46 259.2PTEN, CD44, CDKN2A, MDM2, RB1, MAP2
13roscovitine468.1CDKN2A, TP53, RB1, CDKN1A, MDM2
14flavopiridol46 129.1RB1, CDKN1A, CDKN2A, MDM2, TP53
15phosphatidylinositol468.1FGFR4, FGFR2, CD44, RB1, MAP2, PTEN
16cholesterol46 30 25 1211.0FGFR4, CD44, RB1, MAP2, GFAP, PTEN
175-aza-2deoxycytidine467.9CDKN1A, CDKN2A, FGFR2, PTEN, MDM2, TP53
18thymidylate467.9CDKN2A, CDKN1A, MDM2, RB1, TP53
19agar467.9PTEN, MDM2, FGFR2, RB1, FGFR1, GFAP
20steroid467.9MAP2, CD44, FGFR1, FGFR2, CDKN2A, MDM2
21genistein46 30 62 3 25 1212.8FGFR1, FGFR2, CDKN2A, CDKN1A, MDM2, GFAP
22etoposide46 52 62 1210.8CD44, CDKN1A, MDM2, RB1, PTEN, TP53
23nitric oxide46 25 129.8FGFR2, PTEN, MAP2, CD44, FGFR1, RB1
24glucose467.8FGFR1, CD44, CDKN2A, FGFR2, GFAP, RB1
25cysteine467.8FGFR2, RB1, MDM2, PTEN, CDKN2A, GFAP
26vincristine46 52 129.7MDM2, CD44, CDKN2A, RB1, MAP2, TP53
27testosterone46 62 25 1210.7FGFR1, FGFR2, CD44, CDKN2A, MDM2, RB1
28adriamycin467.7CD44, CDKN2A, CDKN1A, MDM2, TP53, RB1
29butyrate467.6CDKN2A, CD44, RB1, TP53, GFAP, CDKN1A
30ly294002467.6TP53, RB1, CDKN1A, CD44, FGFR1, MDM2
315fluorouracil467.6MDM2, PTEN, FGFR2, CDKN1A, TP53, RB1
32cytarabine46 52 129.6GFAP, TP53, CDKN2A, RB1, CDKN1A
33arginine467.5FGFR4, GFAP, MDM2, TP53, FGFR2, CD44
34threonine467.5RB1, PTEN, FGFR1, FGFR2, CDKN2A, CDKN1A
35cycloheximide467.5CDKN2A, CD44, CDKN1A, MDM2, TP53, PTEN
36thymidine46 258.3FGFR1, FGFR2, CD44, MDM2, CDKN1A, RB1
37oxygen46 258.3GFAP, CD44, CDKN2A, CDKN1A, MDM2, RB1
38tyrosine467.2CDKN1A, CD44, FGFR2, FGFR1, PTEN, FGFR4
39oligonucleotide467.2PTEN, FGFR2, CDKN2A, CDKN1A, MDM2, RB1
40doxorubicin46 52 129.1CDKN1A, FGFR2, CD44, CDKN2A, PTEN, TP53
41h2o2466.9CDKN2A, CDKN1A, MDM2, RB1, MAP2, FGFR1
42cisplatin46 52 62 129.9TP53, RB1, FGFR2, CD44, CDKN2A, CDKN1A
43calcium46 52 25 129.9IDH1, INA, GFAP, PTEN, MAP2, RB1
44paraffin466.3FGFR2, FGFR4, CD44, CDKN2A, CDKN1A, MDM2
45progesterone46 30 62 25 1210.3CDKN1A, MDM2, RB1, TP53, PTEN, GFAP
46paclitaxel46 52 128.3FGFR1, FGFR2, CD44, CDKN2A, PTEN, CDKN1A
47estrogen466.2CDKN2A, MDM2, MAP2, TP53, PTEN, GFAP
48serine466.2GFAP, PTEN, TP53, MAP2, RB1, MDM2
49retinoic acid46 257.1RB1, MAP2, TP53, PTEN, GFAP, INA
50vegf466.0TP53, FGFR4, FGFR2, CD44, CDKN2A, CDKN1A

GO Terms for genes affiliated with Gliomatosis Cerebri

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Sources:
17Gene Ontology
See all sources

Cellular components related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.0PTEN, TP53, RB1
2nuclear bodyGO:0166048.9TP53, MDM2, CDKN2A
3protein complexGO:0432348.8CDKN2A, MDM2, TP53
4nucleoplasmGO:0056547.4TP53, RB1, MDM2, CDKN1A, CDKN2A
5nucleolusGO:0057307.3PTEN, TP53, MDM2, CDKN1A, CDKN2A, FGFR2
6cytosolGO:0058297.2IDH1, GFAP, PTEN, TP53, MDM2, CDKN1A
7cytoplasmGO:0057376.8FGFR4, IDH1, GFAP, PTEN, TP53, MAP2
8nucleusGO:0056346.5PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A

Biological processes related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:03560710.3FGFR1, FGFR2
2ventricular zone neuroblast divisionGO:02184710.3FGFR1, FGFR2
3positive regulation of phospholipase activityGO:01051810.3FGFR2, FGFR1
4mesenchymal cell differentiationGO:04876210.3FGFR1, FGFR2
5lung-associated mesenchyme developmentGO:06048410.3FGFR1, FGFR2
6organ inductionGO:00175910.2FGFR4, FGFR1
7branching involved in salivary gland morphogenesisGO:06044510.2FGFR2, FGFR1
8long-term synaptic potentiationGO:06029110.2GFAP, PTEN
9positive regulation of cardiac muscle cell proliferationGO:06004510.1FGFR2, FGFR1
10branching involved in prostate gland morphogenesisGO:06044210.1CD44, FGFR2
11negative regulation of G1/S transition of mitotic cell cycleGO:200013410.1PTEN, RB1
12negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.0MDM2, CD44
13cell migrationGO:01647710.0PTEN, FGFR4, FGFR1
14response to arsenic-containing substanceGO:04668510.0PTEN, CDKN1A
15peptidyl-tyrosine phosphorylationGO:01810810.0FGFR1, FGFR4, FGFR2
16negative regulation of epithelial cell proliferationGO:0506809.9PTEN, RB1, FGFR2
17cell cycle checkpointGO:0000759.9RB1, CDKN2A
18insulin receptor signaling pathwayGO:0082869.9FGFR1, FGFR4, FGFR2
19protein autophosphorylationGO:0467779.9FGFR1, FGFR4, FGFR2
20digestive tract developmentGO:0485659.9FGFR2, RB1
21skeletal system morphogenesisGO:0487059.9FGFR2, FGFR1
22protein destabilizationGO:0316489.9MDM2, CDKN2A
23positive regulation of ERK1 and ERK2 cascadeGO:0703749.8CD44, FGFR2, FGFR4
24positive regulation of cell cycleGO:0457879.8FGFR1, FGFR2
25embryonic organ developmentGO:0485689.7FGFR2, TP53
26angiogenesisGO:0015259.6FGFR1, FGFR2, PTEN
27cellular senescenceGO:0903989.6CDKN1A, CDKN2A
28negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.6CDKN1A, CDKN2A
29negative regulation of phosphorylationGO:0423269.5CDKN2A, CDKN1A
30replicative senescenceGO:0903999.5TP53, CDKN2A
31positive regulation of cell cycle arrestGO:0711589.4CDKN2A, TP53
32mitotic cell cycle arrestGO:0718509.4CDKN1A, TP53
33positive regulation of cell proliferationGO:0082849.4PTEN, MDM2, FGFR2, FGFR4, FGFR1
34G1/S transition of mitotic cell cycleGO:0000829.2RB1, CDKN1A, CDKN2A
35cellular response to ionizing radiationGO:0714799.1TP53, CDKN1A
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.1CDKN1A, MDM2, TP53
37negative regulation of cell growthGO:0303088.9TP53, CDKN1A, CDKN2A
38negative regulation of transcription from RNA polymerase II promoterGO:0001228.8FGFR1, FGFR2, MDM2, TP53
39phosphatidylinositol-mediated signalingGO:0480158.8FGFR1, FGFR4, FGFR2, CDKN1A, MDM2, PTEN
40fibroblast growth factor receptor signaling pathwayGO:0085438.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
41Fc-epsilon receptor signaling pathwayGO:0380958.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
42epidermal growth factor receptor signaling pathwayGO:0071738.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
43neurotrophin TRK receptor signaling pathwayGO:0480118.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
44innate immune responseGO:0450878.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
45positive regulation of reactive oxygen species metabolic processGO:20003798.7CDKN1A, TP53
46negative regulation of transcription, DNA-templatedGO:0458928.7CDKN2A, MDM2, RB1, TP53
47negative regulation of cell proliferationGO:0082858.6PTEN, TP53, CDKN1A, CDKN2A
48Ras protein signal transductionGO:0072658.5TP53, RB1, CDKN1A, CDKN2A
49cell cycle arrestGO:0070508.5CDKN2A, CDKN1A, RB1, TP53
50negative regulation of apoptotic processGO:0430668.4PTEN, TP53, MDM2, CDKN1A, CD44

Molecular functions related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050079.8FGFR1, FGFR4, FGFR2
2fibroblast growth factor bindingGO:0171349.8FGFR1, FGFR4, FGFR2
3protein tyrosine kinase activityGO:0047139.6FGFR2, FGFR4, FGFR1
4heparin bindingGO:0082019.5FGFR2, FGFR4, FGFR1
5cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.3CDKN2A, CDKN1A
6MDM2/MDM4 family protein bindingGO:0973719.3CDKN2A, TP53
7p53 bindingGO:0020398.9TP53, MDM2, CDKN2A
8ubiquitin protein ligase bindingGO:0316258.9MDM2, RB1, TP53
9identical protein bindingGO:0428028.3FGFR1, MDM2, RB1, TP53
10protein bindingGO:0055156.2PTEN, TP53, MAP2, RB1, MDM2, CDKN1A

Products for genes affiliated with Gliomatosis Cerebri

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Sources for Gliomatosis Cerebri

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet