MCID: GLM004
MIFTS: 50

Gliomatosis Cerebri malady

Neuronal, Cancer categories

Summaries for Gliomatosis Cerebri

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Gliomatosis cerebri is a type of brain cancer.  it is a variant form of glioblastoma multiforme. it is characterized by scattered and widespread tumor cells that can cause the cerebrum, cerebellum, or brain stem to enlarge. signs and symptoms may include personality changes, memory disturbance, headache, hemiparesis, and seizures.  because this tumor is so diffuse it can be challenging to treat and the prognosis for people with gliomatosis cerebri is generally poor. last updated: 3/5/2009

MalaCards: Gliomatosis Cerebri, also known as astrocytosis cerebri, is related to parkinson's disease and adenoma. An important gene associated with Gliomatosis Cerebri is GFAP (glial fibrillary acidic protein), and among its related pathways are Alzheimers Disease Pathway and Signaling by FGFR1 mutants. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and whole blood, and related mouse phenotypes are vision/eye and embryogenesis.

Wikipedia:64 Gliomatosis cerebri (infiltrative diffuse astrocytosis) is a rare primary brain tumor. It is commonly... more...

Aliases & Classifications for Gliomatosis Cerebri

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
gliomatosis cerebri:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

gliomatosis cerebri 8 43 45 49 61
astrocytosis cerebri 8


External Ids:

Disease Ontology8 DOID:6128
MeSH35 D018302
SNOMED-CT57 26138003
NCIt40 C4318

Related Diseases for Gliomatosis Cerebri

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gliomatosis Cerebri via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.2PTEN
2adenoma30.2RB1, CDKN2A, CD44, CDKN1A, FGFR1, FGFR4
3astrocytoma30.2TP53, MDM2, IDH1, RB1, MAP2, PTEN
4brain glioma10.5
5spinal cord glioma10.4
6acute disseminated encephalomyelitis10.3
7neurofibromatosis10.2
8obsessive-compulsive disorder10.2
9scotoma10.2
10n syndrome10.2
11ollier disease10.2
12brain medulloblastoma10.2
13diffuse astrocytoma10.2
14limbic encephalitis10.2
15rasmussen encephalitis10.2
16epidermal nevus10.2
17headache10.2
18neurosarcoidosis10.2
19benign glioma10.2
20chordoma10.0GFAP
21paraganglioma10.0GFAP
22subependymal giant cell astrocytoma10.0GFAP
23myelodysplastic syndromes10.0FGFR1
24endometriosis10.0PTEN
25acute leukemia10.0FGFR1
26obesity10.0FGFR1
27prostate small cell carcinoma10.0INA
28cholesteatoma10.0FGFR2
29peutz-jeghers syndrome10.0PTEN
30achondroplasia10.0FGFR2
31intraductal papilloma10.0IDH1
32osteoglophonic dysplasia10.0FGFR1
33uterine sarcoma10.0MDM2
34gliosarcoma10.0GFAP, PTEN
35hemangiopericytoma10.0MDM2
36ductal carcinoma in situ10.0TP53
37neuroblastoma10.0TP53
38kidney cancer10.0TP53
39tongue cancer10.0CDKN1A
40gemistocytic astrocytoma10.0PTEN, GFAP
41myeloid leukemia10.0CDKN1A
42teratoma10.0GFAP, FGFR1
43schizophrenia10.0MAP2
44cholangiocarcinoma10.0TP53
45stomach cancer10.0TP53
46ulcerative colitis10.0TP53
47gallbladder cancer10.0TP53
48choriocarcinoma10.0FGFR2
49turcot syndrome10.0PTEN
50arthritis10.0CD44

Graphical network of the top 20 diseases related to Gliomatosis Cerebri:



Diseases related to gliomatosis cerebri

Clinical Features for Gliomatosis Cerebri

Drugs & Therapeutics for Gliomatosis Cerebri

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gliomatosis Cerebri

Drug clinical trials:

Search ClinicalTrials for Gliomatosis Cerebri

Search NIH Clinical Center for Gliomatosis Cerebri

Search CenterWatch for Gliomatosis Cerebri

Genetic Tests for Gliomatosis Cerebri

Anatomical Context for Gliomatosis Cerebri

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Gliomatosis Cerebri:

33
Spinal cord, Brain, Whole blood, Cerebellum, Breast, Pituitary

Animal Models for Gliomatosis Cerebri or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Gliomatosis Cerebri:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2FGFR2, GFAP
2MP:000538010.1FGFR2
3MP:00053679.6FGFR2, FGFR1
4MP:00053769.4IDH1, GFAP, FGFR4, FGFR2
5MP:00036318.9INA, GFAP, MAP2, CDKN1A, FGFR2
6MP:00053908.8FGFR1, RB1, CD44, CDKN1A, FGFR2
7MP:00053897.7FGFR2, CDKN2A, CDKN1A, CD44, TP53, PTEN
8MP:00053697.6CDKN1A, CDKN2A, MDM2, FGFR1, GFAP, TP53
9MP:00053887.6TP53, FGFR4, FGFR2, CDKN1A, CD44, RB1
10MP:00053827.6FGFR1, FGFR2, TP53, CDKN1A, RB1, PTEN
11MP:00107717.2FGFR2, CDKN2A, RB1, TP53, FGFR1, MDM2
12MP:00053797.1FGFR1, RB1, CDKN2A, CDKN1A, FGFR2, CD44
13MP:00053707.0TP53, PTEN, RB1, FGFR2, CDKN1A, CD44
14MP:00028737.0MDM2, RB1, CD44, FGFR2, INA, TP53
15MP:00053857.0MDM2, RB1, CD44, CDKN1A, PTEN, FGFR2
16MP:00030126.9TP53, MDM2, FGFR1, FGFR2, CDKN1A, CD44
17MP:00020066.8MDM2, CDKN1A, FGFR2, CDKN2A, PTEN, RB1
18MP:00053816.5TP53, RB1, CDKN2A, CD44, FGFR2, FGFR1
19MP:00053976.5RB1, MDM2, IDH1, CDKN1A, CD44, CDKN2A
20MP:00053876.2PTEN, FGFR1, FGFR2, CD44, CDKN1A, RB1
21MP:00053846.2FGFR1, FGFR4, TP53, FGFR2, CDKN1A, CD44
22MP:00053866.1FGFR2, TP53, PTEN, GFAP, FGFR1, MDM2
23MP:00053785.9TP53, PTEN, GFAP, FGFR4, FGFR1, FGFR2
24MP:00107685.8CDKN1A, CD44, FGFR1, MAP2, FGFR4, TP53

Publications for Gliomatosis Cerebri

Sources:
51PubMed
See all sources

Articles related to Gliomatosis Cerebri:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
18F FDG PET/CT in a child with gliomatosis cerebri. (23122744)
2013
2
Letter to the editor: gliomatosis cerebri. (23198839)
2013
3
Response: gliomatosis cerebri. (23495379)
2013
4
Gliomatosis cerebri: clinical characteristics, management, and outcomes. (23341100)
2013
5
Infiltration of the Optic Chiasm, Nerve, and Disc by Gliomatosis Cerebri. (23287703)
2013
6
A rare case of gliomatosis cerebri presenting as dementia. (22690056)
2012
7
An initial exploration of surgery following radiotherapy for the treatment of gliomatosis cerebri. (23253734)
2012
8
MRI features of gliomatosis cerebri in a dog. (22413939)
2012
9
Subcutaneous tumor seeding after biopsy in gliomatosis cerebri. (21837541)
2012
10
Gliomatosis cerebri diagnostic challenge: two case reports. (21881469)
2011
11
Gliomatosis cerebri presenting as a recurrent cervical myelopathy. (20924592)
2011
12
Gliomatosis cerebri: a possible clinical and neuroradiologic "stroke mimic". (21364359)
2011
13
Gliomatosis cerebri: diagnostic considerations in three cases. (21339680)
2011
14
Gliomatosis cerebri. (20679750)
2010
15
A case of gliomatosis cerebri mimicking limbic encephalitis: malignant transformation to glioblastoma. (20606365)
2010
16
Gliomatosis cerebri, imaging findings of 12 cases. (20334921)
2010
17
Correlative analysis of gene expression profile and prognosis in patients with gliomatosis cerebri. (19517475)
2009
18
MAP-2 immunoexpression in gliomatosis cerebri. (19309409)
2009
19
Gliomatosis cerebri: clinicopathologic study of 33 cases and comparison of mass forming and diffuse types. (19353837)
2009
20
Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri. (18285534)
2008
21
Oligodendroglial gliomatosis cerebri. Case report. (17285105)
2006
22
Value of diagnosis and differential diagnosis of MRI and MR spectroscopy in gliomatosis cerebri. (16769190)
2006
23
Parkinsonism and dementia due to gliomatosis cerebri mimicking sporadic Creutzfeldt-Jakob disease (CJD). (16421148)
2006
24
Multivoxel magnetic resonance spectroscopy in gliomatosis cerebri. (16334845)
2005
25
Chemotherapy as initial treatment in gliomatosis cerebri: results with temozolomide. (15277636)
2004
26
Mitochondrial DNA as a clonal tumor cell marker: gliomatosis cerebri. (12587789)
2003
27
Analysis of TP53 and PTEN in gliomatosis cerebri. (12734658)
2003
28
Gliomatosis cerebri: clinical, neurochemical and neuroradiological response to temozolomide administration. (14684203)
2003
29
Dynamic contrast-enhanced T2*-weighted MR imaging of gliomatosis cerebri. (11900998)
2002
30
Gliomatosis cerebri in a 10-year-old girl masquerading as diffuse encephalomyelitis and spinal cord tumour. (11221900)
2001
31
Fluid-attenuated inversion-recovery MR imaging of gliomatosis cerebri. (11218032)
2001
32
Radiation therapy approach in gliomatosis cerebri--case reports and literature review. (11130015)
2000
33
Serial positron emission tomography (PET) in gliomatosis cerebri treated with radiotherapy: a case report. (10675576)
2000
34
Oligodendrocytic gliomatosis cerebri. (10883346)
2000
35
MRI diagnosis of gliomatosis cerebri. (10082346)
1999
36
Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis. (10442461)
1999
37
Gliomatosis cerebri with neurofibromatosis: an autopsy-proven case. (10392491)
1999
38
Gliomatosis cerebri: disconnection of the cortical grey matter, demonstrated on PET scan. (11013687)
1998
39
Gliomatosis cerebri--an appropriate diagnosis? Case reports. (9191428)
1997
40
Chromosomes in gliomatosis cerebri. (8527397)
1995
41
MR and positron emission tomography with fludeoxyglucose F 18 in gliomatosis cerebri. (7484643)
1995
42
Gliomatosis cerebri presenting as intractable epilepsy during early childhood. (7539465)
1995
43
Gliomatosis cerebri at the 17-year-old girl--correlations of histological, CT and MRI appearance. (7889339)
1994
44
Gliomatosis cerebri following radiation and chemotherapy. (8416236)
1993
45
Gliomatosis cerebri: a case report with autopsy correlation. (1528447)
1992
46
Oligodendroglial gliomatosis cerebri. (1592395)
1992
47
Diagnosis and management of gliomatosis cerebri: recent trends. (1759182)
1991
48
Gliomatosis cerebri: a clinical, radiological and pathological report of four cases. (1650563)
1991
49
Gliomatosis cerebri--report of a case. (4000710)
1985
50
Gliomatosis cerebri diffusa. A case report. (7270086)
1981

Genetic Variations for Gliomatosis Cerebri

Expression for genes affiliated with Gliomatosis Cerebri

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gliomatosis Cerebri

Search GEO for disease gene expression data for Gliomatosis Cerebri.

Pathways for genes affiliated with Gliomatosis Cerebri

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 60Tocris Bioscience, 56SinoBiological, 12EMD Millipore, 4Cell Signaling Technology, 30KEGG, 53R&D Systems
See all sources

Pathways related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FGFR2, FGFR1, FGFR4
2
Hide members
9.6FGFR2, FGFR1, FGFR4
39.6FGFR2, FGFR1, FGFR4
4
Hide members
9.6FGFR2, FGFR4, FGFR1
5
Hide members
9.3FGFR1, FGFR2, FGFR4, PTEN
69.3MDM2, CDKN1A, RB1
7
Hide members
9.2FGFR2, MDM2, FGFR1, FGFR4
89.1RB1, CDKN1A, CD44
9
Hide members
9.0MDM2, RB1, CDKN1A, PTEN
109.0MDM2, CDKN1A, RB1, PTEN
118.9MDM2, TP53, CDKN1A
128.9CDKN1A, MDM2, TP53
13
Hide members
8.7FGFR1, FGFR2, FGFR4, TP53
148.7CDKN2A, TP53, MDM2
158.6RB1, MDM2, TP53, PTEN
16
Hide members
8.6RB1, PTEN, MDM2, TP53
17
Hide members
8.6CDKN2A, CDKN1A, RB1, MDM2
18
Hide members
8.6CDKN1A, CDKN2A, RB1, MDM2
19
Hide members
8.6PTEN, MDM2, CDKN1A, TP53
20
Hide members
8.6TP53, PTEN, CDKN1A, MDM2
21
Hide members
8.5RB1, CDKN1A, TP53, PTEN
22
Hide members
8.5PTEN, FGFR4, FGFR1, FGFR2, MDM2, CDKN1A
23
Hide members
8.5PTEN, FGFR4, FGFR1, FGFR2, CDKN1A, MDM2
248.3TP53, PTEN, FGFR1, CDKN1A, MDM2
258.3TP53, RB1, MDM2, CDKN2A
26
Hide members
8.3FGFR2, FGFR1, MDM2, CDKN1A, FGFR4, GFAP
27
Hide members
8.2MDM2, CD44, CDKN1A, FGFR2, FGFR1, FGFR4
288.2TP53, MDM2, CDKN2A, CDKN1A
298.2MDM2, TP53, RB1, CDKN1A, PTEN
30
Hide members
8.2CDKN2A, TP53, CDKN1A, RB1
31
Hide members
8.1TP53, PTEN, MDM2, FGFR2, FGFR1, FGFR4
328.0FGFR1, TP53, CD44, MDM2, CDKN1A
338.0MDM2, FGFR2, FGFR4, PTEN, FGFR1, CDKN1A
347.9RB1, CDKN1A, TP53, CD44, MDM2
35
Hide members
7.8TP53, MDM2, CDKN2A, CDKN1A, RB1
36
Hide members
7.8FGFR1, CDKN1A, RB1, TP53, MDM2, FGFR2
377.8CDKN2A, RB1, MDM2, CDKN1A, TP53
38
Hide members
7.8RB1, CDKN2A, CDKN1A, TP53, MDM2
39
Transcription P53 signaling pathway
Hide members
7.8CDKN1A, MDM2, CDKN2A, TP53, RB1
407.7CDKN1A, FGFR2, FGFR1, FGFR4, PTEN, TP53
41
Hide members
7.7CDKN1A, FGFR2, MDM2, PTEN, TP53, FGFR1
427.7MDM2, CDKN1A, FGFR2, FGFR1, FGFR4, PTEN
437.6TP53, CDKN2A, MDM2, RB1, CDKN1A, PTEN
44
Hide members
7.6CDKN2A, MDM2, CDKN1A, PTEN, RB1, TP53
457.5CD44, CDKN1A, PTEN, TP53, CDKN2A, MDM2
46
Hide members
7.5CDKN2A, PTEN, CD44, CDKN1A, MDM2, TP53
477.0CDKN2A, TP53, PTEN, CDKN1A, CD44, MDM2
486.9FGFR1, PTEN, FGFR2, TP53, MDM2, RB1
49
Hide members
6.6FGFR2, CD44, MDM2, CDKN2A, PTEN, RB1
50
Hide members
6.4CDKN2A, CDKN1A, PTEN, GFAP, FGFR4, FGFR1

Compounds for genes affiliated with Gliomatosis Cerebri

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1butyrate4510.4GFAP
2estrogen4510.3MAP2, GFAP
3vincristine45 50 1112.1RB1, MAP2
4pd 161570609.8FGFR1, FGFR2, FGFR4
5su 5402609.8FGFR1, FGFR4, FGFR2
6fiin 1 hydrochloride609.8FGFR4, FGFR1, FGFR2
7serine459.8GFAP, MAP2, CD44
8etoposide45 50 60 1112.5CD44, MDM2, RB1
9pd 17307445 6010.5FGFR2, FGFR1, FGFR4
10ly294002459.1CDKN1A, RB1, MDM2, CD44
11noxa458.8TP53, PTEN, CDKN1A, MDM2
12aflatoxin b145 249.6RB1, TP53, CDKN2A, MDM2
13hpvs458.5CDKN1A, CDKN2A, RB1, TP53
14pd 98,059458.5FGFR2, PTEN, GFAP, FGFR1, MDM2, CDKN1A
15olomoucine45 119.5RB1, CDKN1A, TP53, CDKN2A
16crcs458.4CDKN2A, PTEN, RB1, TP53
17bromodeoxyuridine458.3GFAP, RB1, MAP2, CD44, CDKN1A, FGFR2
18calcium45 50 11 2411.3FGFR1, MAP2, CD44, IDH1, FGFR2, GFAP
19steroid458.2MDM2, RB1, MAP2, CDKN2A, FGFR2, CD44
20roscovitine458.2TP53, CDKN1A, CDKN2A, RB1, MDM2
21cyclophosphamide45 50 1110.2MDM2, RB1, CD44, TP53, PTEN, FGFR2
22flavopiridol45 119.2RB1, CDKN1A, CDKN2A, TP53, MDM2
23cytarabine45 50 1110.1RB1, CDKN2A, CDKN1A, GFAP, TP53
24paraffin458.1CDKN1A, MDM2, MAP2, PTEN, GFAP, FGFR4
255-aza-2deoxycytidine458.0TP53, PTEN, FGFR2, CDKN1A, CDKN2A, MDM2
26phosphatidylinositol458.0FGFR4, MDM2, PTEN, FGFR1, FGFR2, CD44
27agar458.0CDKN1A, FGFR2, PTEN, MDM2, RB1, CDKN2A
28genistein45 29 60 2 11 2412.9PTEN, GFAP, FGFR2, CDKN2A, FGFR1, MDM2
29thymidylate457.9TP53, MDM2, RB1, CDKN2A, CDKN1A
30cyclic amp45 248.9CD44, PTEN, GFAP, CDKN2A, MAP2, RB1
31docetaxel45 50 60 1110.9CDKN1A, CDKN2A, TP53, MAP2, MDM2
32adriamycin457.7MDM2, RB1, CDKN2A, CD44, TP53, CDKN1A
335fluorouracil457.7MDM2, RB1, CDKN1A, PTEN, CDKN2A, TP53
34nitric oxide45 11 249.6MAP2, CDKN2A, CD44, MDM2, FGFR1, RB1
35threonine457.6PTEN, GFAP, MDM2, FGFR1, FGFR2, CDKN2A
36camptothecin45 60 119.5CDKN1A, CDKN2A, MDM2, RB1, TP53
37testosterone45 60 11 2410.5MDM2, PTEN, MAP2, RB1, CDKN2A, CD44
38thymidine45 248.5MDM2, RB1, CD44, TP53, FGFR2, GFAP
39cysteine457.5MDM2, RB1, CDKN2A, CD44, FGFR2, FGFR1
40arginine457.4PTEN, GFAP, FGFR4, FGFR2, CDKN2A, CD44
41oxygen45 248.3CD44, CDKN1A, MDM2, RB1, MAP2, PTEN
42tyrosine457.3CD44, PTEN, MAP2, MDM2, GFAP, RB1
43oligonucleotide457.3CDKN1A, TP53, PTEN, FGFR2, CDKN2A, MDM2
44doxorubicin45 50 119.2FGFR2, CD44, CDKN1A, TP53, PTEN, MDM2
45h2o2457.0FGFR2, MDM2, FGFR1, RB1, MAP2, CDKN2A
46cisplatin45 50 60 119.9TP53, CD44, GFAP, PTEN, MDM2, CDKN2A
47paclitaxel45 50 118.6PTEN, TP53, GFAP, RB1, FGFR2, CDKN1A
48progesterone45 60 29 11 2410.3TP53, MDM2, RB1, PTEN, GFAP, FGFR1
49retinoic acid45 247.1RB1, FGFR1, PTEN, INA, CDKN1A, CD44
50vegf456.0RB1, MAP2, CDKN2A, CD44, CDKN1A, FGFR2

GO Terms for genes affiliated with Gliomatosis Cerebri

Sources:
16Gene Ontology
See all sources

Cellular components related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166058.7RB1, PTEN, TP53
2nuclear bodyGO:0166048.7TP53, CDKN2A, MDM2
3cytosolGO:0058297.1IDH1, MDM2, CDKN2A, CDKN1A, FGFR1, GFAP
4cytoplasmGO:0057376.9MDM2, MAP2, CDKN2A, FGFR2, FGFR4, GFAP

Biological processes related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:03560710.2FGFR2, FGFR1
2ventricular zone neuroblast divisionGO:02184710.2FGFR1, FGFR2
3positive regulation of phospholipase activityGO:01051810.2FGFR2, FGFR1
4mesenchymal cell differentiationGO:04876210.2FGFR1, FGFR2
5lung-associated mesenchyme developmentGO:06048410.2FGFR1, FGFR2
6organ inductionGO:00175910.2FGFR4, FGFR1
7branching involved in salivary gland morphogenesisGO:06044510.1FGFR1, FGFR2
8negative regulation of G1/S transition of mitotic cell cycleGO:200013410.0RB1, PTEN
9positive regulation of cardiac muscle cell proliferationGO:06004510.0FGFR2, FGFR1
10branching involved in prostate gland morphogenesisGO:06044210.0CD44, FGFR2
11peptidyl-tyrosine phosphorylationGO:0181089.9FGFR4, FGFR1, FGFR2
12negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435189.9MDM2, CD44
13cell migrationGO:0164779.9FGFR1, FGFR4, PTEN
14cell cycle checkpointGO:0000759.7CDKN2A, RB1
15long-term synaptic potentiationGO:0602919.7GFAP, PTEN
16positive regulation of ERK1 and ERK2 cascadeGO:0703749.7FGFR4, FGFR2, CD44
17protein destabilizationGO:0316489.6MDM2, CDKN2A
18insulin receptor signaling pathwayGO:0082869.6FGFR1, FGFR4, FGFR2
19negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.5CDKN2A, CDKN1A
20mitotic cell cycle arrestGO:0718509.5CDKN1A, TP53
21negative regulation of phosphorylationGO:0423269.4CDKN2A, CDKN1A
22positive regulation of cell proliferationGO:0082849.3MDM2, FGFR2, FGFR1, FGFR4, PTEN
23replicative senescenceGO:0903999.3CDKN2A, TP53
24cellular senescenceGO:0903989.3CDKN2A, CDKN1A
25positive regulation of cell cycle arrestGO:0711589.2CDKN2A, TP53
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.2TP53, CDKN1A, MDM2
27phosphatidylinositol-mediated signalingGO:0480158.9PTEN, FGFR4, FGFR1, FGFR2, CDKN1A, MDM2
28fibroblast growth factor receptor signaling pathwayGO:0085438.9MDM2, CDKN1A, FGFR2, FGFR1, FGFR4, PTEN
29Fc-epsilon receptor signaling pathwayGO:0380958.9MDM2, CDKN1A, FGFR2, FGFR1, FGFR4, PTEN
30epidermal growth factor receptor signaling pathwayGO:0071738.9MDM2, CDKN1A, FGFR2, FGFR1, FGFR4, PTEN
31neurotrophin TRK receptor signaling pathwayGO:0480118.9MDM2, CDKN1A, FGFR2, FGFR1, FGFR4, PTEN
32innate immune responseGO:0450878.9MDM2, CDKN1A, FGFR2, FGFR1, FGFR4, PTEN
33negative regulation of cell growthGO:0303088.8TP53, CDKN1A, CDKN2A
34Ras protein signal transductionGO:0072658.6RB1, CDKN2A, CDKN1A, TP53
35cell cycle arrestGO:0070508.6TP53, CDKN1A, CDKN2A, RB1
36negative regulation of cell proliferationGO:0082858.4TP53, PTEN, FGFR2, CDKN1A, CDKN2A
37negative regulation of transcription, DNA-dependentGO:0458928.3MDM2, RB1, CDKN2A, TP53
38negative regulation of apoptotic processGO:0430668.2MDM2, CD44, CDKN1A, FGFR1, PTEN, TP53

Molecular functions related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050079.8FGFR4, FGFR1, FGFR2
2fibroblast growth factor bindingGO:0171349.7FGFR2, FGFR1, FGFR4
3protein tyrosine kinase activityGO:0047139.6FGFR4, FGFR1, FGFR2
4heparin bindingGO:0082019.6FGFR2, FGFR1, FGFR4
5cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.3CDKN1A, CDKN2A
6MDM2/MDM4 family protein bindingGO:0973719.1TP53, CDKN2A
7p53 bindingGO:0020398.8TP53, MDM2, CDKN2A
8identical protein bindingGO:0428028.4MDM2, FGFR2, FGFR1, TP53, RB1
9protein bindingGO:0055155.7CD44, TP53, PTEN, FGFR1, FGFR2, MDM2

Products for genes affiliated with Gliomatosis Cerebri

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gliomatosis Cerebri

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet