MCID: GLM004
MIFTS: 50

Gliomatosis Cerebri malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Gliomatosis Cerebri

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 61UMLS via Orphanet
See all sources

Gliomatosis Cerebri, Aliases & Descriptions:

Name: Gliomatosis Cerebri 9 41 43 47 60
 
Astrocytosis Cerebri 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
gliomatosis cerebri:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Disease Ontology9 DOID:6128
MeSH33 D018302
NCIt38 C4318
SNOMED-CT55 26138003
Orphanet47 251582
UMLS via Orphanet61 C0334576

Summaries for Gliomatosis Cerebri

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NIH Rare Diseases:41 Gliomatosis cerebri is a type of brain cancer.  it is a variant form of glioblastoma multiforme. it is characterized by scattered and widespread tumor cells that can cause the cerebrum, cerebellum, or brain stem to enlarge. signs and symptoms may include personality changes, memory disturbance, headache, hemiparesis, and seizures.  because this tumor is so diffuse it can be challenging to treat and the prognosis for people with gliomatosis cerebri is generally poor. last updated: 3/5/2009

MalaCards based summary: Gliomatosis Cerebri, also known as astrocytosis cerebri, is related to pituitary adenoma and medulloblastoma. An important gene associated with Gliomatosis Cerebri is GFAP (glial fibrillary acidic protein), and among its related pathways are Alzheimers Disease Pathway and VEGF Signaling Pathway. The compounds fiin 1 hydrochloride and pd 161570 have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and spinal cord, and related mouse phenotypes are hearing/vestibular/ear and pigmentation.

Wikipedia:63 Gliomatosis cerebri (infiltrative diffuse astrocytosis) is a rare primary brain tumor. It is commonly... more...

Related Diseases for Gliomatosis Cerebri

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Diseases related to Gliomatosis Cerebri via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma30.5FGFR2, FGFR4, RB1
2medulloblastoma30.3FGFR2, MAP2, TP53, GFAP
3breast cancer30.2TP53, CDKN1A, MDM2
4adenoma29.0FGFR1, FGFR4, CD44, CDKN1A, RB1, TP53
5glioblastoma multiforme28.8CDKN1A, MDM2, RB1, MAP2, TP53, PTEN
6glioblastoma28.3IDH1, GFAP, TP53, FGFR4, RB1, MDM2
7astrocytoma27.6INA, IDH1, GFAP, PTEN, TP53, MAP2
8subependymal giant cell astrocytoma10.6GFAP
9encephalitis10.6
10achondroplasia10.5FGFR2
11intraductal papilloma10.5IDH1
12osteoglophonic dysplasia10.5FGFR1
13mismatch repair cancer syndrome10.5PTEN
14dementia10.5
15pineoblastoma10.5GFAP
16gliosarcoma10.5PTEN, GFAP
17gemistocytic astrocytoma10.5GFAP, PTEN
18antley-bixler syndrome10.5FGFR2
19actinic keratosis10.4TP53
20central neurocytoma10.4GFAP, MAP2
21fgfr-related craniosynostosis syndromes10.4FGFR1, FGFR2
22jackson-weiss syndrome10.4FGFR1, FGFR2
23muenke syndrome10.4FGFR2, FGFR1
24viral encephalitis10.4
25cerebritis10.4
26acute disseminated encephalomyelitis10.4
27intracranial hypertension10.4
28pfeiffer syndrome10.4FGFR1, FGFR2
29crouzon syndrome10.3FGFR2, FGFR1
30apert syndrome10.3FGFR2, FGFR1
31hypochondroplasia10.3FGFR1, FGFR2
32pilocytic astrocytoma10.3PTEN, IDH1, GFAP
33acrocephalosyndactylia10.3FGFR1, FGFR2
34prostatic hypertrophy10.3FGFR2, FGFR1
35saethre-chotzen syndrome10.3FGFR2, FGFR1
36meningioma, familial10.3GFAP, PTEN, FGFR2
37giant cell glioblastoma10.3MDM2, GFAP, PTEN
38synostosis10.3FGFR1, FGFR2
39ganglioglioma10.3MAP2, GFAP
40anaplastic ependymoma10.3PTEN, MDM2, GFAP
41lipoma10.3PTEN, MDM2
42retinoblastoma fa - friedreich ataxia10.3MDM2, RB1
43tuberous sclerosis10.3MAP2, GFAP, PTEN
44dedifferentiated liposarcoma10.3MDM2, RB1
45choroid plexus papilloma10.3GFAP, TP53
46craniosynostosis10.2FGFR2, FGFR4, FGFR1
47ganglioneuroma10.2GFAP, PTEN, CD44
48brain cancer10.2MDM2, CD44
49skeletal dysplasia multi-gene panels10.2FGFR1, FGFR2
50rhabdomyosarcoma 2, alveolar10.2RB1, MDM2

Graphical network of the top 20 diseases related to Gliomatosis Cerebri:



Diseases related to gliomatosis cerebri

Symptoms for Gliomatosis Cerebri

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Drugs & Therapeutics for Gliomatosis Cerebri

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Drug clinical trials:

Search ClinicalTrials for Gliomatosis Cerebri

Search NIH Clinical Center for Gliomatosis Cerebri

Genetic Tests for Gliomatosis Cerebri

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Anatomical Context for Gliomatosis Cerebri

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MalaCards organs/tissues related to Gliomatosis Cerebri:

31
Brain, Cerebellum, Spinal cord, Breast, Pituitary

Animal Models for Gliomatosis Cerebri or affiliated genes

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MGI Mouse Phenotypes related to Gliomatosis Cerebri:

35 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8FGFR1, CDKN1A, RB1, FGFR2
2MP:00011868.0FGFR2, PTEN, CDKN2A, MDM2, TP53, RB1
3MP:00053757.7RB1, CDKN1A, PTEN, TP53, FGFR2
4MP:00053827.5MDM2, CDKN1A, FGFR1, RB1, TP53, PTEN
5MP:00028737.3CD44, FGFR2, INA, GFAP, PTEN, RB1
6MP:00053677.3PTEN, TP53, FGFR2, MDM2, CDKN1A, CD44
7MP:00053717.2PTEN, TP53, RB1, FGFR1, CDKN1A, CD44
8MP:00053807.0FGFR2, RB1, TP53, PTEN, MDM2, CDKN1A
9MP:00053887.0CDKN2A, PTEN, TP53, RB1, CDKN1A, CD44
10MP:00030127.0MDM2, RB1, TP53, CDKN1A, FGFR1, CDKN2A
11MP:00053707.0CD44, TP53, RB1, CDKN1A, CDKN2A, PTEN
12MP:00053856.9FGFR1, GFAP, PTEN, TP53, RB1, MDM2
13MP:00053916.9GFAP, FGFR1, FGFR2, CD44, CDKN2A, CDKN1A
14MP:00020066.8CDKN1A, MDM2, RB1, TP53, PTEN, CDKN2A
15MP:00053796.7TP53, MAP2, PTEN, RB1, CDKN1A, CDKN2A
16MP:00053906.7PTEN, RB1, MDM2, CDKN1A, CDKN2A, CD44
17MP:00107716.7MDM2, PTEN, CDKN2A, FGFR1, FGFR2, CD44
18MP:00053816.5CD44, GFAP, TP53, RB1, MDM2, CDKN1A
19MP:00053696.5CDKN2A, FGFR1, FGFR2, CD44, CDKN1A, MDM2
20MP:00053976.5MDM2, CDKN1A, CDKN2A, CD44, FGFR2, RB1
21MP:00053766.4FGFR4, CD44, CDKN2A, CDKN1A, RB1, PTEN
22MP:00053896.4TP53, MAP2, RB1, MDM2, CDKN1A, CDKN2A
23MP:00053876.2IDH1, FGFR1, CDKN1A, MDM2, RB1, TP53
24MP:00053846.2GFAP, FGFR1, FGFR4, FGFR2, PTEN, TP53
25MP:00053866.2PTEN, MAP2, RB1, GFAP, CDKN1A, CDKN2A
26MP:00053785.9TP53, MAP2, RB1, MDM2, CDKN1A, CDKN2A
27MP:00107685.8MAP2, FGFR1, FGFR4, CD44, FGFR2, CDKN2A
28MP:00036315.7CDKN2A, CDKN1A, CD44, FGFR1, FGFR2, MDM2

Publications for Gliomatosis Cerebri

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Articles related to Gliomatosis Cerebri:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
18F FDG PET/CT in a child with gliomatosis cerebri. (23122744)
2013
2
Letter to the editor: gliomatosis cerebri. (23198839)
2013
3
Response: gliomatosis cerebri. (23495379)
2013
4
Bilateral ptosis as initial presentation of gliomatosis cerebri: case report. (23427031)
2013
5
Juvenile parkinsonism as an initial manifestation of gliomatosis cerebri. (24158273)
2013
6
Gliomatosis cerebri diagnostic challenge: two case reports. (21881469)
2011
7
Medulloblastoma and gliomatosis cerebri: rare brain tumors in multiple sclerosis patients. (21234776)
2011
8
NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebri. (21710625)
2011
9
Gliomatosis cerebri. (20530537)
2011
10
Gliomatosis cerebri presenting as idiopathic intracranial hypertension in a child. (21566531)
2011
11
Gliomatosis cerebri: a biopsy and autopsy case report]. (20223351)
2010
12
Gliomatosis cerebri: report of 3 cases. (20809715)
2010
13
Multiple pilomatricomas and gliomatosis cerebri--a new association? (19250412)
2009
14
Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri. (18285534)
2008
15
Array-based comparative genomic hybridization and immunohistochemical studies in gliomatosis cerebri. (18704270)
2008
16
Gliomatosis cerebri: growing evidence for diffuse gliomas with wide invasion. (18416661)
2008
17
Evaluation of molecular genetic alterations associated with tumor progression in a case of gliomatosis cerebri. (16955219)
2007
18
Gliomatosis cerebri mimicking Rasmussen encephalitis. Case report. (18459886)
2007
19
1H MR spectroscopy in the assessment of gliomatosis cerebri. (17312058)
2007
20
Gliomatosis cerebri treatment in 11 elderly patients. (16918128)
2006
21
Gliomatosis cerebri and pituitary adenoma: case report and literature review. (16132522)
2005
22
Clinical diagnosis of gliomatosis cerebri: report of three cases. (15700839)
2004
23
Three-dimensional anisotropy contrast imaging of gliomatosis cerebri: two case reports. (15261511)
2004
24
Pseudo-subarachnoid hemorrhage and cortical visual impairment as the presenting sign of gliomatosis cerebri. (15590541)
2004
25
Gliomatosis cerebri in a young patient showing various cranial nerve manifestations: a case report. (14756448)
2003
26
Mitochondrial DNA as a clonal tumor cell marker: gliomatosis cerebri. (12587789)
2003
27
Dramatic response to chemotherapy in oligodendroglial gliomatosis cerebri. (12913224)
2003
28
Histological and MR correlations in Gliomatosis cerebri. (12241123)
2002
29
Dynamic contrast-enhanced T2*-weighted MR imaging of gliomatosis cerebri. (11900998)
2002
30
Gliomatosis cerebri. (11893895)
2002
31
Histological and genetic diagnosis of gliomatosis cerebri: case report. (11519853)
2001
32
Diagnosis and results of treatment with radiation therapy in gliomatosis cerebri patient: case report. (11355088)
2001
33
CT and MRI findings in gliomatosis cerebri: a neuroradiologic and neuropathologic review of diffuse infiltrating brain neoplasms. (11218033)
2001
34
MRI diagnosis of gliomatosis cerebri. (10082346)
1999
35
Oligodendroglial gliomatosis cerebri: (1)H-MRS suggests elevated glycine/inositol levels. (10525765)
1999
36
Secondary glioblastoma remarkably reduced by steroid administration after anaplastic transformation from gliomatosis cerebri--case report. (10063361)
1998
37
Gliomatosis cerebri: a brain tumour which is too difficult to treat? (9682295)
1998
38
Gliomatosis cerebri: clinical, radiological and pathological report of a case with a stroke-like onset. (9008778)
1996
39
A difficult diagnosis of gliomatosis cerebri. (8837088)
1996
40
Gliomatosis cerebri or benign intracranial hypertension? (7644408)
1995
41
Neuroradiology case of the day. Gliomatosis cerebri. (7785606)
1995
42
Chromosomes in gliomatosis cerebri. (8527397)
1995
43
Gliomatosis cerebri at the 17-year-old girl--correlations of histological, CT and MRI appearance. (7889339)
1994
44
Gliomatosis cerebri: comparison of MR and CT features. (8372774)
1993
45
Gliomatosis cerebri: a case report with autopsy correlation. (1528447)
1992
46
Diagnosis and management of gliomatosis cerebri: recent trends. (1759182)
1991
47
Gliomatosis cerebri with formation of a glioblastoma multiform. Study and follow-up by magnetic resonance and computed tomography. (2848658)
1988
48
Magnetic resonance imaging determination of gliomatosis cerebri. (3822096)
1987
49
Gliomatosis cerebri. Report of four cases and review of the literature. (4499966)
1974
50
Gliomatosis cerebri. (14946583)
1952

Variations for Gliomatosis Cerebri

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Expression for genes affiliated with Gliomatosis Cerebri

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Search GEO for disease gene expression data for Gliomatosis Cerebri.

Pathways for genes affiliated with Gliomatosis Cerebri

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Pathways related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FGFR2, FGFR4, FGFR1
2
Show member pathways
9.3FGFR4, FGFR1, FGFR2, PTEN
3
Show member pathways
9.0CDKN1A, TP53
48.8PTEN, CDKN1A, MDM2, RB1
58.8TP53, MDM2, CDKN2A
6
Show member pathways
8.7TP53, MDM2, CDKN1A
7
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.6PTEN, TP53, RB1, MDM2
88.6PTEN, MDM2, RB1, TP53
9
Show member pathways
8.5CDKN2A, CDKN1A, MDM2, RB1
10
Show member pathways
8.5FGFR4, FGFR1, PTEN, TP53, FGFR2
11
Show member pathways
8.5FGFR4, CD44, CDKN1A, FGFR2, FGFR1
12
Show member pathways
Signal transduction PTEN pathway58
8.4TP53, MDM2, CDKN1A, PTEN
13
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
8.4TP53, PTEN, CDKN1A, MDM2
14
Show member pathways
8.4TP53, MDM2, FGFR2, FGFR1, FGFR4
158.3RB1, MDM2, CDKN2A, TP53
16
Show member pathways
8.3PTEN, MDM2, FGFR2, FGFR4, CDKN1A, FGFR1
17
Show member pathways
8.3MDM2, PTEN, FGFR4, CDKN1A, FGFR1, FGFR2
18
Show member pathways
8.3FGFR4, MDM2, PTEN, CDKN1A, FGFR1, FGFR2
198.2CDKN1A, MDM2, RB1, TP53
208.2TP53, RB1, CDKN1A, CD44
21
Show member pathways
8.1TP53, CDKN2A, MDM2, CDKN1A
22
Show member pathways
8.1PTEN, FGFR4, MDM2, FGFR2, TP53, FGFR1
238.1PTEN, TP53, FGFR1, MDM2, CDKN1A
24
Show member pathways
8.1TP53, CDKN2A, RB1, CDKN1A
25
Show member pathways
8.1FGFR1, FGFR2, GFAP, FGFR4, PTEN, MDM2
268.0PTEN, CDKN1A, MDM2, RB1, TP53
27
Show member pathways
8.0PTEN, RB1, TP53, MDM2, CDKN1A
287.9FGFR1, CD44, CDKN1A, TP53, MDM2
297.8CDKN1A, RB1, MDM2, TP53, CD44
30
Show member pathways
7.7TP53, CDKN1A, CDKN2A, MDM2, RB1
317.7CDKN2A, MDM2, RB1, TP53, CDKN1A
327.7CDKN2A, TP53, MDM2, RB1, CDKN1A
33
Show member pathways
Cell cycle36
7.7TP53, RB1, MDM2, CDKN1A, CDKN2A
34
Show member pathways
7.7TP53, CDKN1A, MDM2, RB1, CDKN2A
35
Show member pathways
7.7MDM2, CDKN1A, RB1, CDKN2A, TP53
367.6CDKN1A, MDM2, PTEN, IDH1, CD44, FGFR2
37
Show member pathways
7.5FGFR1, MDM2, FGFR4, CDKN1A, TP53, PTEN
387.5TP53, CDKN1A, PTEN, FGFR2, FGFR4, FGFR1
397.5FGFR2, FGFR1, CDKN1A, MDM2, TP53, PTEN
40
Show member pathways
DNA damage response36
7.5PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A
417.5PTEN, RB1, CDKN2A, CDKN1A, MDM2, TP53
427.4CD44, CDKN2A, PTEN, CDKN1A, MDM2, TP53
43
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
7.4CD44, PTEN, TP53, CDKN1A, CDKN2A, MDM2
44
Show member pathways
7.3PTEN, TP53, FGFR1, FGFR4, MDM2, FGFR2
457.0CDKN1A, MDM2, CD44, RB1, TP53, PTEN
46
Show member pathways
Signaling Pathways in Glioblastoma36
6.9CDKN2A, FGFR2, FGFR1, CDKN1A, MDM2, RB1
476.9FGFR1, FGFR2, CDKN1A, MDM2, RB1, TP53
48
Show member pathways
6.8RB1, CDKN1A, FGFR1, FGFR4, FGFR2, CDKN2A
49
Show member pathways
6.7MDM2, FGFR1, FGFR4, RB1, TP53, CDKN2A
50
Show member pathways
6.3FGFR1, FGFR4, FGFR2, RB1, TP53, GFAP

Compounds for genes affiliated with Gliomatosis Cerebri

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Compounds related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1fiin 1 hydrochloride599.7FGFR1, FGFR2, FGFR4
2pd 161570599.6FGFR1, FGFR4, FGFR2
3su 5402599.6FGFR2, FGFR4, FGFR1
4aflatoxin b143 249.6MDM2, CDKN2A, RB1, TP53
5hpvs438.4TP53, CDKN2A, RB1, CDKN1A
6olomoucine43 129.4TP53, RB1, CDKN1A, CDKN2A
7hmba438.3CDKN1A, CDKN2A, TP53, RB1
8pd 98,059438.3GFAP, PTEN, RB1, FGFR1, FGFR2, MDM2
9noxa438.3PTEN, CDKN1A, MDM2, TP53
10cyclophosphamide43 49 1210.2CD44, RB1, PTEN, TP53, MDM2, FGFR2
11bromodeoxyuridine438.2FGFR2, CD44, FGFR1, RB1, MAP2, GFAP
12cyclic amp43 249.2PTEN, CD44, CDKN2A, MDM2, RB1, MAP2
13roscovitine438.1CDKN2A, TP53, RB1, CDKN1A, MDM2
14flavopiridol43 129.1RB1, CDKN1A, CDKN2A, MDM2, TP53
15phosphatidylinositol438.1FGFR4, FGFR2, CD44, RB1, MAP2, PTEN
16cholesterol43 28 24 1211.0FGFR4, CD44, RB1, MAP2, GFAP, PTEN
175-aza-2deoxycytidine437.9CDKN1A, CDKN2A, FGFR2, PTEN, MDM2, TP53
18thymidylate437.9CDKN2A, CDKN1A, MDM2, RB1, TP53
19agar437.9PTEN, MDM2, FGFR2, RB1, FGFR1, GFAP
20steroid437.9MAP2, CD44, FGFR1, FGFR2, CDKN2A, MDM2
21genistein43 28 59 2 24 1212.8FGFR1, FGFR2, CDKN2A, CDKN1A, MDM2, GFAP
22etoposide43 49 59 1210.8CD44, CDKN1A, MDM2, RB1, PTEN, TP53
23nitric oxide43 24 129.8FGFR2, PTEN, MAP2, CD44, FGFR1, RB1
24glucose437.8FGFR1, CD44, CDKN2A, FGFR2, GFAP, RB1
25cysteine437.8FGFR2, RB1, MDM2, PTEN, CDKN2A, GFAP
26vincristine43 49 129.7MDM2, CD44, CDKN2A, RB1, MAP2, TP53
27testosterone43 59 24 1210.7FGFR1, FGFR2, CD44, CDKN2A, MDM2, RB1
28adriamycin437.7CD44, CDKN2A, CDKN1A, MDM2, TP53, RB1
29butyrate437.6CDKN2A, CD44, RB1, TP53, GFAP, CDKN1A
30ly294002437.6TP53, RB1, CDKN1A, CD44, FGFR1, MDM2
315fluorouracil437.6MDM2, PTEN, FGFR2, CDKN1A, TP53, RB1
32cytarabine43 49 129.6GFAP, TP53, CDKN2A, RB1, CDKN1A
33arginine437.5FGFR4, GFAP, MDM2, TP53, FGFR2, CD44
34threonine437.5RB1, PTEN, FGFR1, FGFR2, CDKN2A, CDKN1A
35cycloheximide437.5CDKN2A, CD44, CDKN1A, MDM2, TP53, PTEN
36thymidine43 248.3FGFR1, FGFR2, CD44, MDM2, CDKN1A, RB1
37oxygen43 248.3GFAP, CD44, CDKN2A, CDKN1A, MDM2, RB1
38tyrosine437.2CDKN1A, CD44, FGFR2, FGFR1, PTEN, FGFR4
39oligonucleotide437.2PTEN, FGFR2, CDKN2A, CDKN1A, MDM2, RB1
40doxorubicin43 49 129.1CDKN1A, FGFR2, CD44, CDKN2A, PTEN, TP53
41h2o2436.9CDKN2A, CDKN1A, MDM2, RB1, MAP2, FGFR1
42cisplatin43 49 59 129.9TP53, RB1, FGFR2, CD44, CDKN2A, CDKN1A
43calcium43 49 24 129.9IDH1, INA, GFAP, PTEN, MAP2, RB1
44paraffin436.3FGFR2, FGFR4, CD44, CDKN2A, CDKN1A, MDM2
45progesterone43 28 59 24 1210.3CDKN1A, MDM2, RB1, TP53, PTEN, GFAP
46paclitaxel43 49 128.3FGFR1, FGFR2, CD44, CDKN2A, PTEN, CDKN1A
47estrogen436.2CDKN2A, MDM2, MAP2, TP53, PTEN, GFAP
48serine436.2GFAP, PTEN, TP53, MAP2, RB1, MDM2
49retinoic acid43 247.1RB1, MAP2, TP53, PTEN, GFAP, INA
50vegf436.0TP53, FGFR4, FGFR2, CD44, CDKN2A, CDKN1A

GO Terms for genes affiliated with Gliomatosis Cerebri

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Cellular components related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:00166059.0PTEN, TP53, RB1
2nuclear bodyGO:00166048.9TP53, MDM2, CDKN2A
3protein complexGO:00432348.8CDKN2A, MDM2, TP53
4nucleoplasmGO:00056547.4TP53, RB1, MDM2, CDKN1A, CDKN2A
5nucleolusGO:00057307.3PTEN, TP53, MDM2, CDKN1A, CDKN2A, FGFR2
6cytosolGO:00058297.2IDH1, GFAP, PTEN, TP53, MDM2, CDKN1A
7cytoplasmGO:00057376.8FGFR4, IDH1, GFAP, PTEN, TP53, MAP2
8nucleusGO:00056346.5PTEN, TP53, RB1, MDM2, CDKN1A, CDKN2A

Biological processes related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:003560710.3FGFR1, FGFR2
2ventricular zone neuroblast divisionGO:002184710.3FGFR1, FGFR2
3positive regulation of phospholipase activityGO:001051810.3FGFR2, FGFR1
4mesenchymal cell differentiationGO:004876210.3FGFR1, FGFR2
5lung-associated mesenchyme developmentGO:006048410.3FGFR1, FGFR2
6organ inductionGO:000175910.2FGFR4, FGFR1
7branching involved in salivary gland morphogenesisGO:006044510.2FGFR2, FGFR1
8long-term synaptic potentiationGO:006029110.2GFAP, PTEN
9positive regulation of cardiac muscle cell proliferationGO:006004510.1FGFR2, FGFR1
10branching involved in prostate gland morphogenesisGO:006044210.1CD44, FGFR2
11negative regulation of G1/S transition of mitotic cell cycleGO:0200013410.1PTEN, RB1
12negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:004351810.0MDM2, CD44
13cell migrationGO:001647710.0PTEN, FGFR4, FGFR1
14response to arsenic-containing substanceGO:004668510.0PTEN, CDKN1A
15peptidyl-tyrosine phosphorylationGO:001810810.0FGFR1, FGFR4, FGFR2
16negative regulation of epithelial cell proliferationGO:00506809.9PTEN, RB1, FGFR2
17cell cycle checkpointGO:00000759.9RB1, CDKN2A
18insulin receptor signaling pathwayGO:00082869.9FGFR1, FGFR4, FGFR2
19protein autophosphorylationGO:00467779.9FGFR1, FGFR4, FGFR2
20digestive tract developmentGO:00485659.9FGFR2, RB1
21skeletal system morphogenesisGO:00487059.9FGFR2, FGFR1
22protein destabilizationGO:00316489.9MDM2, CDKN2A
23positive regulation of ERK1 and ERK2 cascadeGO:00703749.8CD44, FGFR2, FGFR4
24positive regulation of cell cycleGO:00457879.8FGFR1, FGFR2
25embryonic organ developmentGO:00485689.7FGFR2, TP53
26angiogenesisGO:00015259.6FGFR1, FGFR2, PTEN
27cellular senescenceGO:00903989.6CDKN1A, CDKN2A
28negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.6CDKN1A, CDKN2A
29negative regulation of phosphorylationGO:00423269.5CDKN2A, CDKN1A
30replicative senescenceGO:00903999.5TP53, CDKN2A
31positive regulation of cell cycle arrestGO:00711589.4CDKN2A, TP53
32mitotic cell cycle arrestGO:00718509.4CDKN1A, TP53
33positive regulation of cell proliferationGO:00082849.4PTEN, MDM2, FGFR2, FGFR4, FGFR1
34G1/S transition of mitotic cell cycleGO:00000829.2RB1, CDKN1A, CDKN2A
35cellular response to ionizing radiationGO:00714799.1TP53, CDKN1A
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.1CDKN1A, MDM2, TP53
37negative regulation of cell growthGO:00303088.9TP53, CDKN1A, CDKN2A
38negative regulation of transcription from RNA polymerase II promoterGO:00001228.8FGFR1, FGFR2, MDM2, TP53
39phosphatidylinositol-mediated signalingGO:00480158.8FGFR1, FGFR4, FGFR2, CDKN1A, MDM2, PTEN
40fibroblast growth factor receptor signaling pathwayGO:00085438.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
41Fc-epsilon receptor signaling pathwayGO:00380958.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
42epidermal growth factor receptor signaling pathwayGO:00071738.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
43neurotrophin TRK receptor signaling pathwayGO:00480118.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
44innate immune responseGO:00450878.8PTEN, MDM2, CDKN1A, FGFR2, FGFR4, FGFR1
45positive regulation of reactive oxygen species metabolic processGO:020003798.7CDKN1A, TP53
46negative regulation of transcription, DNA-templatedGO:00458928.7CDKN2A, MDM2, RB1, TP53
47negative regulation of cell proliferationGO:00082858.6PTEN, TP53, CDKN1A, CDKN2A
48Ras protein signal transductionGO:00072658.5TP53, RB1, CDKN1A, CDKN2A
49cell cycle arrestGO:00070508.5CDKN2A, CDKN1A, RB1, TP53
50negative regulation of apoptotic processGO:00430668.4PTEN, TP53, MDM2, CDKN1A, CD44

Molecular functions related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00050079.8FGFR1, FGFR4, FGFR2
2fibroblast growth factor bindingGO:00171349.8FGFR1, FGFR4, FGFR2
3protein tyrosine kinase activityGO:00047139.6FGFR2, FGFR4, FGFR1
4heparin bindingGO:00082019.5FGFR2, FGFR4, FGFR1
5cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.3CDKN2A, CDKN1A
6MDM2/MDM4 family protein bindingGO:00973719.3CDKN2A, TP53
7p53 bindingGO:00020398.9TP53, MDM2, CDKN2A
8ubiquitin protein ligase bindingGO:00316258.9MDM2, RB1, TP53
9identical protein bindingGO:00428028.3FGFR1, MDM2, RB1, TP53
10protein bindingGO:00055156.2PTEN, TP53, MAP2, RB1, MDM2, CDKN1A

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3CDC
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14FMA
22GTR
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24HMDB
25ICD10
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