Gliomatosis Cerebri malady

NIH Rare Diseases: Gliomatosis cerebri is a type of brain cancer.  It is a variant form of glioblastoma multiforme. It is characterized by scattered and widespread tumor cells that can cause the cerebrum, cerebellum, or brain stem to enlarge. Signs and symptoms may include personality changes, memory disturbance, headache, hemiparesis, and seizures.  Because this tumor is so diffuse it can be challenging to treat and the prognosis for people with gliomatosis cerebri is generally poor.³⁰

MalaCards: Gliomatosis Cerebri, also known as gliomatosis cerebri (morphologic abnormality), is related to central neurocytoma and wernicke encephalopathy. An important gene associated with Gliomatosis Cerebri is GFAP (glial fibrillary acidic protein), and among its related pathways are DNA damage ATM/ATR regulation of G1/S checkpoint and Development FGF-family signaling. The compounds vincristine and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and t cells, and related mouse phenotypes are liver/biliary system and reproductive system.

Wikipedia: Gliomatosis cerebri (infiltrative diffuse astrocytosis) is a rare primary brain tumor. It is commonly...⁴⁴ more...

Aliases & Descriptions:

gliomatosis cerebri 6 30 32 43 gliomatosis cerebri (morphologic abnormality) 6

astrocytosis cerebri 6

Diseases related to gliomatosis cerebri by text searches and GeneDecks gene sharing:

(show top 50)    (show all 365)

id	Related Disease	Score	Top Affiliating Genes
1	central neurocytoma	13.4	MAP2, GFAP
2	wernicke encephalopathy	13.3	INA, GFAP
3	intraductal papilloma	13.3	CD44, IDH1
4	cerebrum cancer	13.3	TP53, GFAP
5	choroid plexus carcinoma	13.2	TP53, GFAP
6	mesenchymal cell neoplasm	13.2	CD44, GFAP
7	cervical endometrioid adenocarcinoma	13.2	TP53, PTEN
8	cerebellar liponeurocytoma	13.2	TP53, GFAP
9	jackson-weiss syndrome	13.2	FGFR1, FGFR2
10	fgfr-related craniosynostosis syndromes	13.2	FGFR1, FGFR2
11	osteoglophonic dysplasia	13.2	FGFR1, FGFR2
12	muenke syndrome	13.2	FGFR1, FGFR2
13	prostate small cell carcinoma	13.2	CD44, INA
14	plagiocephaly	13.2	FGFR1, FGFR2
15	cockayne syndrome	13.1	FGFR1, FGFR2
16	ganglioneuroma	13.1	CD44, PTEN, GFAP
17	crouzon syndrome	13.1	FGFR1, FGFR2
18	acrocephalosyndactylia	13.1	FGFR1, FGFR2
19	hypochondroplasia	13.1	FGFR1, FGFR2
20	bilateral retinoblastoma	13.1	RB1, TP53
21	gemistocytic astrocytoma	13.1	TP53, PTEN, GFAP
22	thyroid cancer, follicular	13.0	CDKN1A, PTEN
23	oligoastrocytoma	13.0	IDH1, TP53, GFAP
24	retinoblastoma fa - friedreich ataxia	13.0	RB1, MDM2
25	invasive bladder transitional cell carcinoma	13.0	CDKN1A, TP53
26	mixed cell type cancer	13.0	TP53, GFAP
27	atypical teratoid rhabdoid tumor	13.0	INA, TP53, GFAP
28	bladder transitional cell papilloma	13.0	CDKN1A, TP53
29	papillary thyroid carcinoma	13.0	CD44, FGFR1, PTEN
30	anaplastic ependymoma	13.0	MDM2, PTEN, GFAP
31	subependymal giant cell astrocytoma	12.9	MAP2, TP53, GFAP
32	maxillary sinus squamous cell carcinoma	12.9	CDKN1A, TP53
33	dysembryoplastic neuroepithelial tumor	12.9	MAP2, TP53, GFAP
34	turcot syndrome	12.9	TP53, PTEN
35	craniosynostosis, syndromic	12.9	FGFR1, FGFR2, FGFR4
36	ganglioglioma	12.9	MAP2, TP53, GFAP
37	pineoblastoma	12.9	TP53, GFAP
38	achondroplasia	12.9	FGFR1, FGFR2, FGFR4
39	blastoma	12.9	RB1, TP53, GFAP
40	brain cancer	12.9	CD44, MDM2
41	ganglioneuroblastoma	12.9	CD44, TP53, GFAP
42	craniopharyngioma	12.9	MAP2, TP53, GFAP
43	anal squamous cell carcinoma	12.9	MDM2, TP53
44	gliosis	12.9	MAP2, TP53, GFAP
45	ring chromosomes	12.9	FGFR1, MDM2, GFAP
46	adult medulloblastoma	12.8	MDM2, TP53
47	vulvar cancer	12.8	CD44, TP53, PTEN
48	clear cell adenocarcinoma	12.8	RB1, TP53, PTEN
49	orbit rhabdomyosarcoma	12.8	MDM2, TP53
50	bannayan-riley-ruvalcaba syndrome	12.8	INA, TP53, PTEN

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to gliomatosis cerebri:

²²

MGI Mouse Phenotypes related to gliomatosis cerebri:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	10.2	TP53
2	reproductive system phenotype	MP:0005389	10.1	CD44
3	craniofacial phenotype	MP:0005382	10.0	FGFR2
4	endocrine/exocrine gland phenotype	MP:0005379	9.7	FGFR1, FGFR2
5	embryogenesis phenotype	MP:0005380	9.2	MDM2, FGFR2, FGFR1
6	immune system phenotype	MP:0005387	9.0	GFAP, TP53, FGFR2, FGFR1
7	hematopoietic system phenotype	MP:0005397	8.9	MDM2, FGFR2, CDKN1A
8	normal phenotype	MP:0002873	8.8	GFAP, FGFR2, FGFR1, INA, CD44
9	no phenotypic analysis	MP:0003012	8.8	RB1, CD44, FGFR1, TP53
10	limbs/digits/tail phenotype	MP:0005371	8.6	MDM2, FGFR2, FGFR1, CD44, RB1
11	nervous system phenotype	MP:0003631	8.5	PTEN, MAP2, MDM2, CD44, CDKN1A, RB1
12	mortality/aging	MP:0010768	7.9	GFAP, PTEN, TP53, MAP2, FGFR2, CDKN1A
13	adipose tissue phenotype	MP:0005375	7.9	PTEN, TP53, FGFR2, CDKN1A, RB1
14	pigmentation phenotype	MP:0001186	7.7	PTEN, TP53, MDM2, FGFR2, CDKN2A, RB1
15	renal/urinary system phenotype	MP:0005367	7.5	PTEN, TP53, MDM2, FGFR2, FGFR1, CD44
16	tumorigenesis	MP:0002006	7.2	PTEN, TP53, MDM2, FGFR4, CD44, CDKN2A
17	cardiovascular system phenotype	MP:0005385	7.0	GFAP, PTEN, TP53, MDM2, FGFR2, FGFR1
18	vision/eye phenotype	MP:0005391	6.6	GFAP, PTEN, TP53, FGFR2, FGFR1, CD44
19	skeleton phenotype	MP:0005390	6.5	PTEN, TP53, MDM2, FGFR2, FGFR1, CD44
20	integument phenotype	MP:0010771	6.5	PTEN, TP53, MDM2, FGFR2, FGFR1, CD44
21	digestive/alimentary phenotype	MP:0005381	6.3	RB1, GFAP, PTEN, TP53, MDM2, FGFR2
22	muscle phenotype	MP:0005369	6.3	GFAP, PTEN, TP53, MDM2, FGFR2, FGFR1
23	homeostasis/metabolism phenotype	MP:0005376	6.3	GFAP, PTEN, TP53, FGFR4, FGFR2, CD44
24	behavior/neurological phenotype	MP:0005386	5.9	GFAP, PTEN, TP53, MAP2, MDM2, FGFR2
25	cellular phenotype	MP:0005384	5.9	GFAP, PTEN, TP53, MDM2, FGFR4, FGFR2
26	growth/size phenotype	MP:0005378	5.6	GFAP, PTEN, TP53, MAP2, MDM2, FGFR4

Articles related to gliomatosis cerebri:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	Prognostic stratification of gliomatosis cerebri by I DH1 R132H and INA expression. (21516462)	Desestret V.... Sanson M.	2011	IDH1
2	Gliomatosis cerebri: a biopsy and autopsy case repor t (20223351)	San Millan B.... Gray F.	2010	INA
3	Detection of IDH1 mutations in gliomatosis cerebri, b ut only in tumors with additional solid component: evidence for molecular subty pes. (20514489)	Seiz M.... Hartmann C.	2010	IDH1
4	MAP-2 immunoexpression in gliomatosis cerebri. (19309409)	Romeike B.F.... Mawrin C.	2009	MAP2
5	Evaluation of molecular genetic alterations associated with tumor progression in a case of gliomatosis cerebri. (16955219)	Braeuninger S.... Mawrin C.	2007	TP53, MDM2, RB1
6	Expression of nestin and vimentin in gliomatosis cerebri. (17057885)	Hilbig A.... da Cunha B.S.	2006	GFAP
7	Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion. (15677537)	Suzuki T.... Yoshimine T.	2005	GFAP
8	Alterations of cell cycle regulators in gliomatosis cerebri. (15925990)	Mawrin C.... Dietzmann K.	2005	RB1, CDKN1A, CDKN2A
9	Assessment of tumor cell invasion factors in gliomatosis cerebri. (15981099)	Mawrin C.... von Deimling A.	2005	FGFR4, CD44
10	Distribution of p53 alterations in a case of gliomatosis cerebri. (12605375)	Mawrin C.... Dietzmann K.	2003	TP53
11	Analysis of TP53 and PTEN in gliomatosis cerebri. (12734658)	Mawrin C.... Dietzmann K.	2003	PTEN
12	Histological and genetic diagnosis of gliomatosis cerebri: case report. (11519853)	Yamada S.M.... Yamada S.	2001	FGFR1, FGFR2
13	Gliomatosis cerebri. Clinical, neuropathological, immunohistochemical and morphometric Studies. (8218127)	Galatioto S.... Batolo D.	1993	GFAP
14	Assessment of proliferative potential in gliomatosis cerebri. (1856741)	Hara A.... Mori H.	1991	GFAP

Genes related to gliomatosis cerebri according to GeneCards:

(show all 14)

id	Symbol	Description	Score	GeneCards Section Context
1	GFAP	glial fibrillary acidic protein	11.0	Publications
2	PTEN	phosphatase and tensin homolog	11.0	Publications
3	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
4	INA	internexin neuronal intermediate filament protein, alpha	11.0	Publications
5	FGFR4	fibroblast growth factor receptor 4	11.0	Publications
6	MAP2	microtubule-associated protein 2	11.0	Publications
7	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
8	RB1	retinoblastoma 1	11.0	Publications
9	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
10	CD44	CD44 molecule (Indian blood group)	11.0	Publications
11	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
12	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
13	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
14	TP53	tumor protein p53	11.0	Publications

Pathways related to gliomatosis cerebri according to GeneDecks:

(show all 49)

id	Pathway	Score	Top Affiliating Genes
1	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.4	MDM2
2	Development FGF-family signaling10	10.2	FGFR2
3	Breast Cancer Regulation by Stathmin136	9.9	FGFR4, FGFR2
4	Akt Signaling36	9.8	FGFR1, FGFR4, MDM2
5	Transcription P53 signaling pathway10	9.6	CDKN2A, TP53
6	Pathway_PA16598005034	9.6	FGFR4, FGFR2, FGFR1
7	Alzheimers Disease Pathway36	9.5	FGFR4, FGFR2, FGFR1
8	Development_FGF-family signaling41	9.4	FGFR4, FGFR2, FGFR1
9	Rac1 Pathway36	9.4	FGFR4, FGFR2, FGFR1
10	Angiogenesis3	9.4	FGFR1, FGFR2, FGFR4
11	ATM Pathway36	9.3	TP53, MDM2, CDKN1A
12	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.3	CDKN1A, MDM2, TP53
13	G2-M Phase Transition36	9.3	TP53, MDM2, CDKN1A
14	Chks in Checkpoint Regulation36	9.3	TP53, MDM2, CDKN1A
15	Signaling by EGFR38	9.3	PTEN, MDM2, FGFR4, FGFR2
16	Small cell lung cancer20	9.2	RB1, TP53, PTEN
17	FGF Pathway36	9.2	FGFR4, FGFR2, FGFR1
18	RhoGDI Pathway36	9.2	FGFR1, FGFR2, FGFR4
19	p53 Signaling36	9.2	PTEN, TP53, MDM2, CDKN1A
20	Signal transduction PTEN pathway10	9.2	PTEN, TP53, MDM2, CDKN1A
21	Signal transduction_AKT signaling41	9.1	CDKN1A, MDM2, TP53, PTEN
22	IP3 Pathway36	9.1	PTEN, FGFR4, FGFR2, FGFR1
23	Apoptotic Pathways in Synovial Fibroblasts36	9.0	FGFR1, FGFR2, FGFR4, TP53
24	Non-small cell lung cancer20	9.0	TP53, CDKN2A, RB1
25	HIF1Alpha Pathway36	9.0	CDKN2A, MDM2, TP53
26	Tyrosine Kinases / Adaptors3	8.9	FGFR4, FGFR2, FGFR1
27	Glioblastoma Multiforme36	8.8	PTEN, TP53, MDM2, CDKN1A, RB1
28	Inhibition of Ribosome Biogenesis by p14(ARF)36	8.8	RB1, CDKN2A, MDM2, TP53
29	MAPK signaling pathway20	8.8	FGFR1, FGFR2, FGFR4, TP53
30	JNK Pathway36	8.7	FGFR1, FGFR2, FGFR4, MAP2, TP53
31	Telomerase Components in Cell Signaling36	8.7	TP53, FGFR4, FGFR2, FGFR1, RB1
32	G1-S Phase Transition36	8.6	RB1, CDKN1A, CDKN2A, TP53
33	Cyclins and Cell Cycle Regulation36	8.6	RB1, CDKN1A, CDKN2A, TP53
34	p53 Mediated Apoptosis36	8.4	PTEN, TP53, MDM2, FGFR4, FGFR2, FGFR1
35	PTEN Pathway36	8.4	PTEN, TP53, MDM2, FGFR4, FGFR2, FGFR1
36	p53 signaling pathway20	8.4	PTEN, TP53, MDM2, CDKN2A, CDKN1A
37	Bladder cancer20	8.3	TP53, MDM2, CDKN2A, CDKN1A, RB1
38	Transcription_P53 signaling pathway41	8.3	TP53, MDM2, CDKN2A, CDKN1A, RB1
39	Chronic myeloid leukemia20	8.2	TP53, MDM2, CDKN2A, CDKN1A, RB1
40	Cell cycle20	8.2	TP53, MDM2, CDKN2A, CDKN1A, RB1
41	Cell Cycle / Checkpoint Control3	8.2	TP53, MDM2, CDKN2A, CDKN1A, RB1
42	Glioma20	8.0	PTEN, TP53, MDM2, CDKN2A, CDKN1A, RB1
43	Prostate cancer20	7.9	PTEN, TP53, MDM2, FGFR2, FGFR1, CDKN1A
44	Pathways in cancer20	7.9	PTEN, TP53, MDM2, FGFR2, FGFR1, CDKN1A
45	Mitochondrial Apoptosis36	7.9	TP53, MDM2, FGFR4, FGFR2, FGFR1, CDKN2A
46	Cellular Apoptosis Pathway36	7.9	TP53, MDM2, FGFR4, FGFR2, FGFR1, CDKN2A
47	Melanoma20	7.7	RB1, PTEN, TP53, MDM2, FGFR1, CDKN2A
48	Pancreatic Adenocarcinoma36	7.0	TP53, MDM2, FGFR4, FGFR2, FGFR1, CDKN2A
49	Molecular Mechanisms of Cancer36	6.7	PTEN, TP53, MDM2, FGFR4, FGFR2, FGFR1

Compounds related to gliomatosis cerebri according to GeneDecks:

(show top 50)    (show all 133)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.6	MAP2
2	ly29400232	10.4	CD44
3	h2o232	10.3	FGFR2
4	estrogen32	9.7	GFAP, MAP2, FGFR2
5	threonine32	9.6	FGFR1, MAP2, FGFR2
6	pd 16157042	9.5	FGFR4, FGFR2, FGFR1
7	su 540242	9.4	FGFR4, FGFR1, FGFR2
8	arginine32	9.4	FGFR4, GFAP, MDM2, CD44
9	su 666842	9.3	FGFR4, FGFR1, FGFR2
10	pd 17307432 42	10.3	FGFR1, FGFR2, FGFR4
11	palifermin32 9 9	11.2	FGFR4, FGFR2, FGFR1
12	noxa32	9.0	TP53, MDM2, PTEN, CDKN1A
13	agar32	8.8	FGFR2, RB1, FGFR1, CDKN2A
14	calcium32 9 18 9	11.7	PTEN, IDH1, RB1, MDM2, MAP2, CD44
15	aflatoxin b132 18	9.7	CDKN2A, RB1, MDM2, TP53
16	crcs32	8.7	CDKN2A, TP53, PTEN, RB1
17	doxorubicin32 34 9 9	11.6	TP53, PTEN, CD44, FGFR2, MDM2
18	hpvs32	8.6	RB1, TP53, CDKN2A, CDKN1A
19	olomoucine32 42 9 9	11.6	TP53, CDKN1A, RB1, CDKN2A
20	hmba32	8.6	RB1, CDKN1A, CDKN2A, TP53
21	docetaxel32 34 9 9	11.2	TP53, CDKN1A, MAP2, MDM2, CDKN2A
22	cytarabine32 34 9 9	11.2	GFAP, TP53, CDKN2A, CDKN1A, RB1
23	flavopiridol32 9 9	10.2	CDKN1A, RB1, MDM2, CDKN2A, TP53
24	etoposide32 42 9 9	11.2	RB1, MDM2, PTEN, CDKN1A, CD44, TP53
25	pd 98,05932	8.1	FGFR2, MDM2, FGFR1, RB1, CDKN1A, GFAP
26	thymidylate32	8.0	TP53, MDM2, CDKN1A, RB1, CDKN2A
27	bromodeoxyuridine32	8.0	RB1, FGFR1, CDKN1A, FGFR2, MAP2, GFAP
28	nitric oxide32 9 18 9	10.8	MAP2, CDKN2A, RB1, FGFR2, FGFR1, CD44
29	adriamycin32	7.8	CDKN1A, CDKN2A, CD44, TP53, RB1, MDM2
30	butyrate32	7.7	CDKN1A, RB1, CDKN2A, CD44, TP53, GFAP
31	5-aza-2deoxycytidine32	7.7	TP53, CDKN1A, CDKN2A, FGFR2, MDM2, PTEN
32	phosphatidylinositol32	7.7	RB1, FGFR2, PTEN, MAP2, MDM2, FGFR4
33	vegf32	7.6	MDM2, MAP2, TP53, GFAP, FGFR4, CDKN1A
34	cyclic amp32 18	8.6	MAP2, MDM2, CDKN2A, GFAP, PTEN, CD44
35	camptothecin32 42 9 9	10.5	CDKN1A, CDKN2A, MDM2, TP53, RB1
36	oxygen32 18	8.5	GFAP, CD44, MDM2, MAP2, PTEN, CDKN1A
37	thymidine32 18	8.4	FGFR1, FGFR2, TP53, GFAP, CD44, MDM2
38	5fluorouracil32	7.4	CDKN1A, CDKN2A, RB1, PTEN, FGFR2, MDM2
39	genistein32 9 18 9	10.3	GFAP, RB1, CDKN1A, CDKN2A, FGFR1, FGFR2
40	steroid32	7.2	FGFR1, MDM2, PTEN, RB1, MAP2, FGFR2
41	cycloheximide32	7.1	TP53, CDKN1A, GFAP, PTEN, CDKN2A, CD44
42	testosterone32 9 18 9	10.0	FGFR1, CDKN2A, CD44, FGFR2, MDM2, MAP2
43	oligonucleotide32	7.0	CDKN2A, MDM2, FGFR1, PTEN, TP53, RB1
44	retinoic acid32 42 18	8.9	GFAP, CDKN2A, CDKN1A, RB1, INA, CD44
45	tyrosine32	6.9	PTEN, MDM2, MAP2, FGFR2, RB1, CDKN1A
46	cisplatin32 34 9 9	9.7	CDKN1A, PTEN, TP53, MDM2, GFAP, FGFR2
47	paraffin32	6.1	CDKN1A, TP53, GFAP, PTEN, MAP2, MDM2
48	paclitaxel32 34 9 9	9.0	TP53, MAP2, MDM2, FGFR2, FGFR1, CD44
49	progesterone32 42 9 18 9	10.0	FGFR2, MDM2, RB1, CD44, CDKN2A, CDKN1A
50	serine32	6.0	GFAP, FGFR1, RB1, TP53, MAP2, FGFR2

Cellular components related to gliomatosis cerebri according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	PML body	GO:016605	9.3	RB1, TP53, PTEN
2	nuclear body	GO:016604	8.6	CDKN2A, MDM2, TP53
3	cytosol	GO:005829	6.8	GFAP, PTEN, TP53, IDH1, MDM2, FGFR1

Biological processes related to gliomatosis cerebri according to GeneDecks:

(show all 31)

id	Name	GO ID	Score	Top Affiliating Genes
1	long-term synaptic potentiation	GO:060291	10.2	GFAP, PTEN
2	central nervous system neuron development	GO:021954	10.0	MAP2, FGFR1
3	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	GO:035607	9.9	FGFR1, FGFR2
4	ventricular zone neuroblast division	GO:021847	9.9	FGFR1, FGFR2
5	positive regulation of phospholipase activity	GO:010518	9.8	FGFR1, FGFR2
6	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO:043518	9.8	CD44, MDM2
7	lung-associated mesenchyme development	GO:060484	9.8	FGFR1, FGFR2
8	mesenchymal cell differentiation	GO:048762	9.8	FGFR1, FGFR2
9	phosphatidylinositol-mediated signaling	GO:048015	9.7	PTEN, MDM2, FGFR1
10	branching involved in salivary gland morphogenesis	GO:060445	9.7	FGFR1, FGFR2
11	branching involved in prostate gland morphogenesis	GO:060442	9.7	CD44, FGFR2
12	mitotic cell cycle arrest	GO:071850	9.7	CDKN1A, TP53
13	cell migration	GO:016477	9.6	PTEN, FGFR4, FGFR1
14	peptidyl-tyrosine phosphorylation	GO:018108	9.5	FGFR1, FGFR2, FGFR4
15	digestive tract development	GO:048565	9.4	RB1, FGFR2
16	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.3	FGFR4, FGFR2, CD44
17	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:006977	9.3	TP53, MDM2, CDKN1A
18	rRNA transcription	GO:009303	9.2	TP53, CDKN2A
19	positive regulation of cardiac muscle cell proliferation	GO:060045	9.2	FGFR1, FGFR2
20	cellular senescence	GO:090398	9.1	CDKN1A, CDKN2A
21	positive regulation of cell cycle arrest	GO:071158	9.1	CDKN2A, TP53
22	G1 phase of mitotic cell cycle	GO:000080	9.1	CDKN2A, CDKN1A, RB1
23	replicative senescence	GO:090399	9.0	CDKN1A, CDKN2A, TP53
24	fibroblast growth factor receptor signaling pathway	GO:008543	8.9	PTEN, MDM2, FGFR4, FGFR2, FGFR1
25	positive regulation of cell proliferation	GO:008284	8.9	PTEN, MDM2, FGFR4, FGFR2, FGFR1
26	Ras protein signal transduction	GO:007265	8.6	TP53, CDKN2A, CDKN1A, RB1
27	negative regulation of cell growth	GO:030308	8.6	TP53, CDKN2A, CDKN1A, RB1
28	cell cycle arrest	GO:007050	8.6	TP53, CDKN2A, CDKN1A, RB1
29	negative regulation of apoptotic process	GO:043066	8.4	CDKN1A, CD44, FGFR1, MDM2, TP53, PTEN
30	cell cycle checkpoint	GO:000075	8.2	TP53, MDM2, CDKN2A, CDKN1A, RB1
31	negative regulation of cell proliferation	GO:008285	8.1	PTEN, TP53, FGFR2, CDKN2A, CDKN1A

Molecular functions related to gliomatosis cerebri according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	fibroblast growth factor-activated receptor activity	GO:005007	9.3	FGFR1, FGFR2, FGFR4
2	fibroblast growth factor binding	GO:017134	9.2	FGFR4, FGFR2, FGFR1
3	protein tyrosine kinase activity	GO:004713	9.1	FGFR1, FGFR2, FGFR4
4	cyclin-dependent protein kinase inhibitor activity	GO:004861	8.8	CDKN2A, CDKN1A
5	protein binding	GO:005515	5.8	TP53, MAP2, MDM2, FGFR2, FGFR1, CD44