MCID: GLM004
MIFTS: 56

Gliomatosis Cerebri malady

Neuronal diseases, Cancer diseases categories

Summaries for Gliomatosis Cerebri

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Gliomatosis cerebri is a type of brain cancer.  it is a variant form of glioblastoma multiforme. it is characterized by scattered and widespread tumor cells that can cause the cerebrum, cerebellum, or brain stem to enlarge. signs and symptoms may include personality changes, memory disturbance, headache, hemiparesis, and seizures.  because this tumor is so diffuse it can be challenging to treat and the prognosis for people with gliomatosis cerebri is generally poor. last updated: 3/5/2009

MalaCards: Gliomatosis Cerebri, also known as astrocytosis cerebri, is related to glioblastoma multiforme and pituitary adenoma. An important gene associated with Gliomatosis Cerebri is GFAP (glial fibrillary acidic protein), and among its related pathways are FGFR2c ligand binding and activation and Signaling by FGFR1 mutants. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and spinal cord, and related mouse phenotypes are vision/eye and embryogenesis.

Wikipedia:63 Gliomatosis cerebri (infiltrative diffuse astrocytosis) is a rare primary brain tumor. It is commonly... more...

Aliases & Classifications for Gliomatosis Cerebri

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
gliomatosis cerebri:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

gliomatosis cerebri 8 42 44 48 60
astrocytosis cerebri 8


External Ids:

Disease Ontology8 DOID:6128
MeSH34 D018302
SNOMED-CT56 26138003
NCIt39 C4318
SNOMED-CT via Orphanet57 26138003

Related Diseases for Gliomatosis Cerebri

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gliomatosis Cerebri via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1glioblastoma multiforme30.4MAP2, CDKN2A, CD44, CDKN1A, RB1, MDM2
2pituitary adenoma30.2RB1, FGFR2, FGFR4
3medulloblastoma30.2MAP2, FGFR2, GFAP, TP53
4adenoma30.1RB1, TP53, CDKN2A, CD44, CDKN1A, FGFR1
5breast cancer30.1CDKN2A, CD44, TP53, FGFR2, RB1, FGFR1
6astrocytoma30.1FGFR2, FGFR1, FGFR4, INA, GFAP, PTEN
7dementia10.4
8encephalomyelitis10.4
9cerebritis10.3
10acute disseminated encephalomyelitis10.3
11encephalitis10.3
12hypertension10.3
13intracranial hypertension10.3
14neurofibromatosis10.1
15obsessive-compulsive disorder10.1
16scotoma10.1
17neuronitis10.1
18ollier disease10.1
19brain glioma10.1
20brain medulloblastoma10.1
21cervicitis10.1
22hodgkin's lymphoma10.1
23hydrocephalus10.1
24multiple sclerosis10.1
25chordoma10.0GFAP
26paraganglioma10.0GFAP
27subependymal giant cell astrocytoma10.0GFAP
28myelodysplastic syndromes10.0FGFR1
29endometriosis10.0PTEN
30acute leukemia10.0FGFR1
31parkinson's disease10.0PTEN
32obesity10.0FGFR1
33prostate small cell carcinoma10.0INA
34cholesteatoma10.0FGFR2
35peutz-jeghers syndrome10.0PTEN
36achondroplasia10.0FGFR2
37intraductal papilloma10.0IDH1
38osteoglophonic dysplasia10.0FGFR1
39uterine sarcoma10.0MDM2
40gliosarcoma10.0GFAP, PTEN
41hemangiopericytoma10.0MDM2
42ductal carcinoma in situ10.0TP53
43neuroblastoma10.0TP53
44kidney cancer10.0TP53
45tongue cancer10.0CDKN1A
46gemistocytic astrocytoma10.0GFAP, PTEN
47myeloid leukemia10.0CDKN1A
48teratoma10.0FGFR1, GFAP
49schizophrenia10.0MAP2
50cholangiocarcinoma10.0TP53

Graphical network of the top 20 diseases related to Gliomatosis Cerebri:



Diseases related to gliomatosis cerebri

Clinical Features for Gliomatosis Cerebri

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Drugs & Therapeutics for Gliomatosis Cerebri

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gliomatosis Cerebri

Drug clinical trials:

Search ClinicalTrials for Gliomatosis Cerebri

Search NIH Clinical Center for Gliomatosis Cerebri

Search CenterWatch for Gliomatosis Cerebri

Genetic Tests for Gliomatosis Cerebri

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Anatomical Context for Gliomatosis Cerebri

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32MalaCards
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MalaCards organs/tissues related to Gliomatosis Cerebri:

32
Brain, Cerebellum, Spinal cord, Breast, Pituitary

Animal Models for Gliomatosis Cerebri or affiliated genes

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36MGI
See all sources

MGI Mouse Phenotypes related to Gliomatosis Cerebri:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2FGFR2, GFAP
2MP:000538010.1FGFR2
3MP:00053679.6FGFR2, FGFR1
4MP:00053769.4IDH1, GFAP, FGFR4, FGFR2
5MP:00036318.9INA, GFAP, MAP2, CDKN1A, FGFR2
6MP:00053908.8FGFR1, RB1, CD44, CDKN1A, FGFR2
7MP:00053897.7FGFR2, CDKN2A, CDKN1A, CD44, TP53, PTEN
8MP:00053697.6CDKN1A, CDKN2A, MDM2, FGFR1, GFAP, TP53
9MP:00053887.6TP53, FGFR4, FGFR2, CDKN1A, CD44, RB1
10MP:00053827.6FGFR1, FGFR2, TP53, CDKN1A, RB1, PTEN
11MP:00107717.2FGFR2, CDKN2A, RB1, TP53, FGFR1, MDM2
12MP:00053797.1FGFR1, RB1, CDKN2A, CDKN1A, FGFR2, CD44
13MP:00053707.0TP53, PTEN, RB1, FGFR2, CDKN1A, CD44
14MP:00028737.0MDM2, RB1, CD44, FGFR2, INA, TP53
15MP:00053857.0MDM2, RB1, CD44, CDKN1A, PTEN, FGFR2
16MP:00030126.9TP53, MDM2, FGFR1, FGFR2, CDKN1A, CD44
17MP:00020066.8MDM2, CDKN1A, FGFR2, CDKN2A, PTEN, RB1
18MP:00053816.5TP53, RB1, CDKN2A, CD44, FGFR2, FGFR1
19MP:00053976.5RB1, MDM2, IDH1, CDKN1A, CD44, CDKN2A
20MP:00053876.2PTEN, FGFR1, FGFR2, CD44, CDKN1A, RB1
21MP:00053846.2FGFR1, FGFR4, TP53, FGFR2, CDKN1A, CD44
22MP:00053866.1FGFR2, TP53, PTEN, GFAP, FGFR1, MDM2
23MP:00053785.9TP53, PTEN, GFAP, FGFR4, FGFR1, FGFR2
24MP:00107685.8CDKN1A, CD44, FGFR1, MAP2, FGFR4, TP53

Publications for Gliomatosis Cerebri

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Sources:
50PubMed
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Articles related to Gliomatosis Cerebri:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Letter to the editor: gliomatosis cerebri. (23198839)
2013
2
Bilateral ptosis as initial presentation of gliomatosis cerebri: case report. (23427031)
2013
3
Juvenile parkinsonism as an initial manifestation of gliomatosis cerebri. (24158273)
2013
4
Gliomatosis cerebri: clinical characteristics, management, and outcomes. (23341100)
2013
5
Teaching NeuroImages: diffuse cerebral neurosarcoidosis mimicking gliomatosis cerebri. (23940026)
2013
6
Presentation patterns and outcome of gliomatosis cerebri. (22740882)
2012
7
Marked response of gliomatosis cerebri to temozolomide and whole brain radiotherapy. (22341931)
2012
8
Gliomatosis cerebri. (22230515)
2012
9
Medulloblastoma and gliomatosis cerebri: rare brain tumors in multiple sclerosis patients. (21234776)
2011
10
Gliomatosis cerebri: a possible clinical and neuroradiologic "stroke mimic". (21364359)
2011
11
Gliomatosis cerebri: a biopsy and autopsy case report]. (20223351)
2010
12
A case of Neuro-Behcet disease mimicking gliomatosis cerebri. (19797795)
2010
13
Gliomatosis cerebri mimicking chemotherapy-induced leukoencephalopathy in a patient with non-Hodgkin's lymphoma. (20371962)
2010
14
Gray matter involvement predicts chemosensitivity and prognosis in gliomatosis cerebri. (19667319)
2009
15
Gliomatosis cerebri. (19390795)
2009
16
Gliomatosis cerebri type II: two case reports. (19830138)
2009
17
Late-onset obsessive compulsive disorder associated with possible gliomatosis cerebri. (19548182)
2009
18
Array-based comparative genomic hybridization and immunohistochemical studies in gliomatosis cerebri. (18704270)
2008
19
Gliomatosis cerebri: growing evidence for diffuse gliomas with wide invasion. (18416661)
2008
20
Procarbazine and CCNU as initial treatment in gliomatosis cerebri. (18841032)
2008
21
Gliomatosis cerebri with favorable outcome in a child: a case report. (18833342)
2008
22
Epilepsy surgery in children with gliomatosis cerebri. (17565595)
2007
23
Oligodendroglial gliomatosis cerebri. Case report. (17285105)
2006
24
Expression of nestin and vimentin in gliomatosis cerebri. (17057885)
2006
25
Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion. (15677537)
2005
26
Multivoxel magnetic resonance spectroscopy in gliomatosis cerebri. (16334845)
2005
27
Gliomatosis cerebri: quantitative proof of vessel recruitment by cooptation instead of angiogenesis. (16266053)
2005
28
Molecular genetic alterations in gliomatosis cerebri: what can we learn about the origin and course of the disease? (16222524)
2005
29
Combined surgery, radiation, and chemotherapy for oligodendroglial gliomatosis cerebri. (15327240)
2004
30
Role of proton magnetic resonance spectroscopy in the diagnosis of gliomatosis cerebri: a unique pattern of normal choline but elevated Myo-inositol metabolite levels. (14716242)
2004
31
Gliomatosis cerebri in a young patient showing various cranial nerve manifestations: a case report. (14756448)
2003
32
Mitochondrial DNA as a clonal tumor cell marker: gliomatosis cerebri. (12587789)
2003
33
Distribution of p53 alterations in a case of gliomatosis cerebri. (12605375)
2003
34
Proton MR spectroscopy of gliomatosis cerebri: case report of elevated myoinositol with normal choline levels. (12748099)
2003
35
Gliomatosis cerebri evaluated by 18Falpha-methyl tyrosine positron-emission tomography. (13680026)
2003
36
Dynamic contrast-enhanced T2*-weighted MR imaging of gliomatosis cerebri. (11900998)
2002
37
Gliomatosis cerebri: molecular pathology and clinical course. (12325066)
2002
38
Gliomatosis cerebri. (11252301)
2001
39
Gliomatosis cerebri: a rare cause of progressive headache. (15613185)
1998
40
Gliomatosis cerebri with good prognosis. (9384803)
1997
41
A difficult diagnosis of gliomatosis cerebri. (8837088)
1996
42
Gliomatosis cerebri. (8628879)
1996
43
Gliomatosis cerebri: a case report. (8916129)
1996
44
Gliomatosis cerebri. Results with radiation therapy. (8859193)
1996
45
Gliomatosis cerebri or benign intracranial hypertension? (7644408)
1995
46
Computed tomography of gliomatosis cerebri. (3392285)
1988
47
Gliomatosis cerebri, report of a clinically diagnosed and histologically confirmed case. (3568520)
1987
48
Abnormal neuronal migration and gliomatosis cerebri in epidermal nevus syndrome. (7223374)
1981
49
Gliomatosis cerebri. (13434574)
1957
50
Gliomatosis cerebri. (13369666)
1956

Genetic Variations for Gliomatosis Cerebri

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Expression for genes affiliated with Gliomatosis Cerebri

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gliomatosis Cerebri

Search GEO for disease gene expression data for Gliomatosis Cerebri.

Pathways for genes affiliated with Gliomatosis Cerebri

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Sources:
53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN, 59Tocris Bioscience, 55SinoBiological, 12EMD Millipore, 4Cell Signaling Technology, 29KEGG, 52R&D Systems
See all sources

Pathways related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6FGFR1, FGFR4, FGFR2
2
Hide members
9.6FGFR4, FGFR2, FGFR1
39.6FGFR4, FGFR1, FGFR2
4
Hide members
9.6FGFR1, FGFR4, FGFR2
59.6FGFR4, FGFR2, FGFR1
6
Hide members
9.3FGFR1, FGFR4, PTEN, FGFR2
79.3CDKN1A, RB1, MDM2
8
Hide members
9.2MDM2, FGFR2, FGFR4, FGFR1
99.1CDKN1A, CD44, RB1
10
Hide members
9.0CDKN1A, PTEN, MDM2, RB1
119.0CDKN1A, MDM2, RB1, PTEN
128.9MDM2, CDKN1A, TP53
138.9MDM2, CDKN1A, TP53
14
Hide members
8.7FGFR4, TP53, FGFR1, FGFR2
158.7CDKN2A, MDM2, TP53
168.6MDM2, RB1, PTEN, TP53
17
Hide members
8.6RB1, MDM2, PTEN, TP53
18
Hide members
8.6MDM2, RB1, CDKN1A, CDKN2A
19
Hide members
8.6CDKN2A, CDKN1A, MDM2, RB1
20
Hide members
8.6CDKN1A, TP53, MDM2, PTEN
21
Hide members
8.6PTEN, TP53, MDM2, CDKN1A
22
Hide members
8.5CDKN1A, FGFR1, FGFR2, PTEN, MDM2, FGFR4
23
Hide members
8.5FGFR2, MDM2, CDKN1A, PTEN, FGFR1, FGFR4
248.3PTEN, TP53, CDKN1A, FGFR1, MDM2
258.3CDKN2A, RB1, MDM2, TP53
26
Hide members
8.3PTEN, GFAP, FGFR2, CDKN1A, MDM2, FGFR4
27
Hide members
8.2FGFR2, MDM2, FGFR4, FGFR1, CD44, CDKN1A
288.2CDKN2A, TP53, CDKN1A, MDM2
298.2CDKN1A, PTEN, RB1, MDM2, TP53
30
Hide members
8.2RB1, CDKN2A, CDKN1A, TP53
31
Hide members
8.1FGFR4, TP53, PTEN, FGFR2, MDM2, FGFR1
328.0TP53, MDM2, CD44, CDKN1A, FGFR1
338.0FGFR1, CDKN1A, MDM2, FGFR4, PTEN, FGFR2
347.9CDKN1A, RB1, MDM2, CD44, TP53
35
Hide members
7.8RB1, TP53, FGFR1, CDKN1A, FGFR2, MDM2
367.8MDM2, CDKN2A, TP53, CDKN1A, RB1
37
Hide members
7.8MDM2, TP53, CDKN1A, RB1, CDKN2A
38
Hide members
7.8MDM2, CDKN1A, CDKN2A, RB1, TP53
39
Transcription P53 signaling pathway
Hide members
7.8RB1, CDKN1A, CDKN2A, TP53, MDM2
407.7MDM2, FGFR1, FGFR2, PTEN, CDKN1A, TP53
417.7FGFR1, MDM2, CDKN1A, FGFR2, FGFR4, TP53
42
Hide members
7.7FGFR4, FGFR1, MDM2, CDKN1A, PTEN, TP53
437.6MDM2, RB1, CDKN2A, TP53, CDKN1A, PTEN
44
Hide members
7.6RB1, PTEN, CDKN2A, CDKN1A, TP53, MDM2
457.5CDKN2A, CD44, TP53, MDM2, PTEN, CDKN1A
46
Hide members
7.5TP53, CD44, MDM2, CDKN2A, CDKN1A, PTEN
477.0CD44, MDM2, CDKN2A, RB1, CDKN1A, PTEN
486.9TP53, PTEN, FGFR2, CDKN1A, CDKN2A, RB1
49
Hide members
6.6TP53, PTEN, FGFR4, FGFR1, FGFR2, CD44
50
Hide members
6.4RB1, CDKN1A, FGFR2, FGFR1, FGFR4, PTEN

Compounds for genes affiliated with Gliomatosis Cerebri

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1butyrate4410.4GFAP
2estrogen4410.3MAP2, GFAP
3vincristine44 49 1112.1RB1, MAP2
4pd 161570599.8FGFR1, FGFR2, FGFR4
5su 5402599.8FGFR1, FGFR4, FGFR2
6fiin 1 hydrochloride599.8FGFR4, FGFR1, FGFR2
7serine449.8GFAP, MAP2, CD44
8etoposide44 49 59 1112.5CD44, MDM2, RB1
9pd 17307444 5910.5FGFR2, FGFR1, FGFR4
10ly294002449.1CDKN1A, RB1, MDM2, CD44
11noxa448.8TP53, PTEN, CDKN1A, MDM2
12aflatoxin b144 249.6RB1, TP53, CDKN2A, MDM2
13hpvs448.5CDKN1A, CDKN2A, RB1, TP53
14pd 98,059448.5FGFR2, PTEN, GFAP, FGFR1, MDM2, CDKN1A
15olomoucine44 119.5RB1, CDKN1A, TP53, CDKN2A
16crcs448.4CDKN2A, PTEN, RB1, TP53
17bromodeoxyuridine448.3GFAP, RB1, MAP2, CD44, CDKN1A, FGFR2
18calcium44 49 11 2411.3FGFR1, MAP2, CD44, IDH1, FGFR2, GFAP
19steroid448.2MDM2, RB1, MAP2, CDKN2A, FGFR2, CD44
20roscovitine448.2TP53, CDKN1A, CDKN2A, RB1, MDM2
21cyclophosphamide44 49 1110.2MDM2, RB1, CD44, TP53, PTEN, FGFR2
22flavopiridol44 119.2RB1, CDKN1A, CDKN2A, TP53, MDM2
23cytarabine44 49 1110.1RB1, CDKN2A, CDKN1A, GFAP, TP53
24paraffin448.1CDKN1A, MDM2, MAP2, PTEN, GFAP, FGFR4
255-aza-2deoxycytidine448.0TP53, PTEN, FGFR2, CDKN1A, CDKN2A, MDM2
26phosphatidylinositol448.0FGFR4, MDM2, PTEN, FGFR1, FGFR2, CD44
27agar448.0CDKN1A, FGFR2, PTEN, MDM2, RB1, CDKN2A
28genistein44 28 59 2 11 2412.9PTEN, GFAP, FGFR2, CDKN2A, FGFR1, MDM2
29thymidylate447.9TP53, MDM2, RB1, CDKN2A, CDKN1A
30cyclic amp44 248.9CD44, PTEN, GFAP, CDKN2A, MAP2, RB1
31docetaxel44 49 59 1110.9CDKN1A, CDKN2A, TP53, MAP2, MDM2
32adriamycin447.7MDM2, RB1, CDKN2A, CD44, TP53, CDKN1A
335fluorouracil447.7MDM2, RB1, CDKN1A, PTEN, CDKN2A, TP53
34nitric oxide44 11 249.6MAP2, CDKN2A, CD44, MDM2, FGFR1, RB1
35threonine447.6PTEN, GFAP, MDM2, FGFR1, FGFR2, CDKN2A
36camptothecin44 59 119.5CDKN1A, CDKN2A, MDM2, RB1, TP53
37testosterone44 59 11 2410.5MDM2, PTEN, MAP2, RB1, CDKN2A, CD44
38thymidine44 248.5MDM2, RB1, CD44, TP53, FGFR2, GFAP
39cysteine447.5MDM2, RB1, CDKN2A, CD44, FGFR2, FGFR1
40arginine447.4PTEN, GFAP, FGFR4, FGFR2, CDKN2A, CD44
41oxygen44 248.3CD44, CDKN1A, MDM2, RB1, MAP2, PTEN
42tyrosine447.3CD44, PTEN, MAP2, MDM2, GFAP, RB1
43oligonucleotide447.3CDKN1A, TP53, PTEN, FGFR2, CDKN2A, MDM2
44doxorubicin44 49 119.2FGFR2, CD44, CDKN1A, TP53, PTEN, MDM2
45h2o2447.0FGFR2, MDM2, FGFR1, RB1, MAP2, CDKN2A
46cisplatin44 49 59 119.9TP53, CD44, GFAP, PTEN, MDM2, CDKN2A
47paclitaxel44 49 118.6PTEN, TP53, GFAP, RB1, FGFR2, CDKN1A
48progesterone44 59 28 11 2410.3TP53, MDM2, RB1, PTEN, GFAP, FGFR1
49retinoic acid44 247.1RB1, FGFR1, PTEN, INA, CDKN1A, CD44
50vegf446.0RB1, MAP2, CDKN2A, CD44, CDKN1A, FGFR2

GO Terms for genes affiliated with Gliomatosis Cerebri

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Sources:
16Gene Ontology
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Cellular components related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166058.7RB1, PTEN, TP53
2nuclear bodyGO:0166048.7TP53, CDKN2A, MDM2
3cytosolGO:0058297.1IDH1, MDM2, CDKN2A, CDKN1A, FGFR1, GFAP
4cytoplasmGO:0057376.9MDM2, MAP2, CDKN2A, FGFR2, FGFR4, GFAP

Biological processes related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:03560710.2FGFR2, FGFR1
2ventricular zone neuroblast divisionGO:02184710.2FGFR1, FGFR2
3positive regulation of phospholipase activityGO:01051810.2FGFR1, FGFR2
4mesenchymal cell differentiationGO:04876210.2FGFR2, FGFR1
5lung-associated mesenchyme developmentGO:06048410.2FGFR2, FGFR1
6organ inductionGO:00175910.2FGFR4, FGFR1
7branching involved in salivary gland morphogenesisGO:06044510.1FGFR1, FGFR2
8negative regulation of G1/S transition of mitotic cell cycleGO:200013410.0RB1, PTEN
9branching involved in prostate gland morphogenesisGO:06044210.0FGFR2, CD44
10long-term synaptic potentiationGO:06029110.0PTEN, GFAP
11positive regulation of cardiac muscle cell proliferationGO:06004510.0FGFR1, FGFR2
12peptidyl-tyrosine phosphorylationGO:0181089.9FGFR2, FGFR1, FGFR4
13negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435189.9CD44, MDM2
14cell migrationGO:0164779.9FGFR1, PTEN, FGFR4
15protein destabilizationGO:0316489.7MDM2, CDKN2A
16cell cycle checkpointGO:0000759.7RB1, CDKN2A
17positive regulation of ERK1 and ERK2 cascadeGO:0703749.7FGFR4, CD44, FGFR2
18negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.5CDKN2A, CDKN1A
19mitotic cell cycle arrestGO:0718509.5CDKN1A, TP53
20insulin receptor signaling pathwayGO:0082869.5FGFR2, FGFR1, FGFR4
21negative regulation of phosphorylationGO:0423269.4CDKN1A, CDKN2A
22positive regulation of cell proliferationGO:0082849.3FGFR2, MDM2, PTEN, FGFR4, FGFR1
23replicative senescenceGO:0903999.3CDKN2A, TP53
24positive regulation of cell cycle arrestGO:0711589.3TP53, CDKN2A
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.2MDM2, CDKN1A, TP53
26cellular senescenceGO:0903989.1CDKN2A, CDKN1A
27phosphatidylinositol-mediated signalingGO:0480158.9PTEN, MDM2, CDKN1A, FGFR2, FGFR1, FGFR4
28fibroblast growth factor receptor signaling pathwayGO:0085438.9MDM2, CDKN1A, FGFR2, FGFR1, FGFR4, PTEN
29Fc-epsilon receptor signaling pathwayGO:0380958.9MDM2, PTEN, FGFR4, CDKN1A, FGFR2, FGFR1
30epidermal growth factor receptor signaling pathwayGO:0071738.9CDKN1A, FGFR4, MDM2, FGFR1, FGFR2, PTEN
31neurotrophin TRK receptor signaling pathwayGO:0480118.9PTEN, FGFR4, FGFR1, FGFR2, CDKN1A, MDM2
32innate immune responseGO:0450878.9FGFR2, FGFR4, MDM2, CDKN1A, FGFR1, PTEN
33negative regulation of cell growthGO:0303088.8TP53, CDKN2A, CDKN1A
34Ras protein signal transductionGO:0072658.6TP53, CDKN1A, CDKN2A, RB1
35cell cycle arrestGO:0070508.6TP53, CDKN1A, CDKN2A, RB1
36negative regulation of cell proliferationGO:0082858.4CDKN2A, FGFR2, CDKN1A, PTEN, TP53
37negative regulation of transcription, DNA-dependentGO:0458928.3RB1, CDKN2A, TP53, MDM2
38negative regulation of apoptotic processGO:0430668.2PTEN, TP53, CD44, MDM2, CDKN1A, FGFR1

Molecular functions related to Gliomatosis Cerebri according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050079.8FGFR4, FGFR1, FGFR2
2fibroblast growth factor bindingGO:0171349.7FGFR2, FGFR1, FGFR4
3protein tyrosine kinase activityGO:0047139.6FGFR4, FGFR1, FGFR2
4heparin bindingGO:0082019.6FGFR2, FGFR1, FGFR4
5cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.3CDKN1A, CDKN2A
6MDM2/MDM4 family protein bindingGO:0973719.1TP53, CDKN2A
7p53 bindingGO:0020398.8TP53, MDM2, CDKN2A
8identical protein bindingGO:0428028.4MDM2, FGFR2, FGFR1, TP53, RB1
9protein bindingGO:0055155.7CD44, TP53, PTEN, FGFR1, FGFR2, MDM2

Products for genes affiliated with Gliomatosis Cerebri

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Sources for Gliomatosis Cerebri

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet