Gliosarcoma malady

Wikipedia: Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain...⁴⁴ more...

MalaCards: Gliosarcoma, also known as glioblastoma with a sarcomatous component, is related to giant cell glioblastoma and anaplastic astrocytoma. An important gene associated with Gliosarcoma is GFAP (glial fibrillary acidic protein), and among its related pathways are 14-3-3 Induced Intracellular Signaling and Breast Cancer Regulation by Stathmin1. The drug carmustine and the compounds egcg and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Aliases & Descriptions:

gliosarcoma 6 30 8 32 43 glioblastoma with a sarcomatous component 6 glioblastoma with sarcomatous component 6

gliosarcoma (morphologic abnormality) 6 sarcomatous glioblastoma 30 glioblastoma 43

Diseases related to gliosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 520)

id	Related Disease	Score	Top Affiliating Genes
1	giant cell glioblastoma	31.0	VIM, S100B, TP53, PTEN, GFAP
2	anaplastic astrocytoma	28.6	RB1, S100B, CDKN2A, CDK4, MGMT, TP53
3	t-cell leukemia	28.2	CDKN3, CDK4, CCND3, TKT, TFRC
4	fibrous histiocytoma	28.1	VIM, S100B, ACTC1
5	oligodendroglioma	27.5	BRAF, CDKN2A, MGMT, PTEN, GFAP
6	gliomatosis cerebri	27.1	RB1, CDKN2A, TP53, PTEN, GFAP
7	anoxia	27.0	GCH1, TP53, PTGS2, GFAP
8	pilocytic astrocytoma	26.9	BRAF, S100B, CDKN2A, CDKN3, CDK4, MGMT
9	breast cancer	26.8	CDK4, CCND3, GJA1, PTGS2, EGF
10	glioblastoma	26.6	RB1, CDKN2A, CDKN3, CDK4, MGMT, GJA1
11	neurofibromatosis	26.3	KIT, KITLG, S100B, ENO2, PDGFRA
12	hypoxia	26.3	KIT, KITLG, RB1, BRAF, S100B, CDKN2A
13	hemangioblastoma	26.0	VIM, S100B, ENO2, TP53, GFAP
14	pleomorphic xanthoastrocytoma	25.9	BRAF, CDKN2A, CDK4, TP53, GFAP
15	li-fraumeni syndrome	25.9	RB1, CDKN2A, TP53, PTEN
16	cytomegalovirus infection	25.2	CDKN2A, CDKN3, PDGFRA, EGF, GFAP, TKT
17	astrocytoma	25.2	KIT, RB1, VIM, BRAF, S100B, CDKN2A
18	measles	25.2	S100B, CDK4, CCND3, TP53, PTGS2
19	wilms tumor	25.2	VIM, CDKN2A, CDK4, ENO2, TP53, PTGS2
20	diffuse astrocytoma	25.2	BRAF, CDKN2A, CDK4, MGMT, TP53, PTEN
21	meningitis	25.1	RB1, VIM, S100B, ENO2, GJA1, TP53
22	meningioma	24.7	RB1, VIM, S100B, CDKN2A, CDKN3, CDK4
23	b-cell lymphomas	24.7	RB1, CDKN2A, CDK4, MGMT, CCND3, TP53
24	anaplastic oligodendroglioma	24.6	RB1, CDKN2A, CDK4, MGMT, TP53, PTEN
25	retinoblastoma	24.6	KIT, KITLG, RB1, VIM, S100B, CDKN2A
26	herpes simplex	23.3	VIM, S100B, MSI1, CDKN2A, CDKN3, MGMT
27	asthma	23.2	KIT, KITLG, TP53, PTEN, PTGS2, PDGFRA
28	parkinson's disease	22.8	GCH1, RB1, VIM, S100B, CDKN3, PTEN
29	malignant fibrous histiocytoma	22.7	KITLG, RB1, VIM, S100B, CDKN2A, CDK4
30	histiocytoma	22.7	KITLG, RB1, VIM, S100B, CDKN2A, CDK4
31	medulloblastoma	22.7	KIT, RB1, VIM, S100B, MSI1, CDKN2A
32	liver cancer	22.6	RB1, CDKN2A, CDKN3, CDK4, TP53, PTEN
33	germ cell tumor	22.6	KIT, KITLG, RB1, BRAF, CDKN2A, CDKN3
34	neuroblastoma	22.0	KIT, KITLG, RB1, VIM, S100B, CDKN2A
35	immunodeficiency	21.6	KITLG, GCH1, RB1, VIM, S100B, CDKN3
36	pancreatic carcinoma	21.6	KITLG, RB1, VIM, CDKN2A, CDKN3, CDK4
37	colon carcinoma	21.5	KIT, KITLG, BRAF, CDKN3, CDK4, MGMT
38	leukemia	21.4	KIT, KITLG, RB1, VIM, BRAF, CDKN2A
39	thyroid cancer	21.4	KIT, VIM, BRAF, CDKN2A, CDKN3, ENO2
40	cerebritis	21.3	KITLG, VIM, S100B, CDKN2A, CDKN3, CDK4
41	colon cancer	21.2	RB1, VIM, BRAF, S100B, MSI1, CDKN2A
42	leiomyosarcoma	21.0	KIT, RB1, VIM, S100B, CDKN2A, CDK4
43	malignant glioma	20.9	GCH1, RB1, VIM, BRAF, S100B, MSI1
44	neuronitis	20.7	KIT, KITLG, GCH1, RB1, VIM, BRAF
45	carcinoma	20.6	KIT, KITLG, RB1, VIM, BRAF, S100B
46	hepatocellular carcinoma	20.3	KIT, RB1, VIM, BRAF, CDKN2A, CDKN3
47	adenoiditis	19.8	KIT, VIM, S100B, CDKN2A, CDKN3, CDK4
48	prostatitis	19.4	KIT, KITLG, RB1, VIM, BRAF, S100B
49	myeloid leukemia	19.1	KIT, KITLG, RB1, VIM, BRAF, CDKN2A
50	melanoma	18.3	KIT, KITLG, RB1, VIM, BRAF, S100B

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine

MalaCards organs/tissues related to gliosarcoma:

²²

MGI Mouse Phenotypes related to gliosarcoma:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	EPHB6, TKT, GJA1
2	liver/biliary system phenotype	MP:0005370	9.8	KIT, TP53
3	normal phenotype	MP:0002873	9.6	EPHB6, GFAP, PDGFRA, GJA1, BRAF
4	reproductive system phenotype	MP:0005389	9.6	GJA1, PTGS2, PDGFRA, EPHB6
5	embryogenesis phenotype	MP:0005380	9.3	PDGFRA, CDK4, BRAF, VIM, KIT
6	craniofacial phenotype	MP:0005382	9.1	PDGFRB, PDGFRA, GJA1, MSI1, KITLG, KIT
7	hematopoietic system phenotype	MP:0005397	9.0	EPHB6, TFRC, PDGFRA, GJA1, CDK4, BRAF
8	limbs/digits/tail phenotype	MP:0005371	9.0	PDGFRA, RB1, KITLG, KIT
9	nervous system phenotype	MP:0003631	8.6	STOML3, PDGFRA, PTEN, CDK4, MSI1, BRAF
10	no phenotypic analysis	MP:0003012	8.3	RB1, MGMT, GJA1, TP53, PTGS2, STOML3
11	adipose tissue phenotype	MP:0005375	8.2	TKT, PDGFRB, PTGS2, PTEN, TP53, BRAF
12	immune system phenotype	MP:0005387	7.9	PDGFRA, PDGFRB, GFAP, TFRC, EPHB6, TP53
13	pigmentation phenotype	MP:0001186	7.7	PDGFRA, PTEN, TP53, CDKN2A, BRAF, RB1
14	renal/urinary system phenotype	MP:0005367	7.7	EPHB6, TKT, PDGFRB, PDGFRA, PTGS2, PTEN
15	behavior/neurological phenotype	MP:0005386	7.5	PTEN, PDGFRA, GFAP, TKT, STOML3, EPHB6
16	skeleton phenotype	MP:0005390	7.2	PTGS2, PTEN, TP53, GJA1, CDKN2A, MSI1
17	integument phenotype	MP:0010771	7.2	EPHB6, STOML3, EGF, PDGFRA, TP53, CDK4
18	mortality/aging	MP:0010768	7.2	PTEN, PDGFRA, PDGFRB, GFAP, TKT, TFRC
19	digestive/alimentary phenotype	MP:0005381	7.0	EPHB6, TFRC, GFAP, EGF, PDGFRB, PDGFRA
20	muscle phenotype	MP:0005369	6.5	PTEN, PTGS2, PDGFRA, PDGFRB, ACTC1, GFAP
21	tumorigenesis	MP:0002006	6.5	EPHB6, PDGFRA, PTGS2, PTEN, TP53, CCND3
22	cardiovascular system phenotype	MP:0005385	6.3	PTEN, PTGS2, PDGFRA, PDGFRB, ACTC1, GFAP
23	vision/eye phenotype	MP:0005391	5.7	KIT, TKT, GFAP, EGF, PDGFRB, PTGS2
24	cellular phenotype	MP:0005384	5.5	PTEN, PTGS2, PDGFRA, PDGFRB, ACTC1, GFAP
25	homeostasis/metabolism phenotype	MP:0005376	5.1	TP53, PTEN, PTGS2, PDGFRA, PDGFRB, ACTC1
26	growth/size phenotype	MP:0005378	5.1	PDGFRA, PDGFRB, EGF, ACTC1, GFAP, TKT

Articles related to gliosarcoma:

(show all 20)

id	Title	Authors	Year	Affiliating Genes
1	O6-methylguanine DNA methyltransferase status determi ned by promoter methylation and immunohistochemistry in gliosarcoma and their c linical implications. (20556478)	Kang S.H.... Chung Y.G.	2011	MGMT
2	Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo. (19937755)	deCarvalho A.C.... Mikkelsen T.	2010	MSI1
3	Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. (19075262)	Prados M.D.... Haas-Kogan D.A.	2009	MGMT, CDKN3
4	Gliosarcoma with osteosarcomatous features: a short i llustrated review. (19399365)	Charfi S.... Boudawara T.	2009	GFAP
5	Immunohistochemistry of gliosarcoma with liposarcomatous differentiation. (18477220)	Fukuda T.... Suzuki T.	2008	RB1
6	Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas. (16373964)	Reis R.M.... Lopes J.M.	2005	PDGFRA, PDGFRB, KIT
7	Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery. (14529825)	Niranjan A.... Glorioso J.C.	2003	GJA1
8	A cyclooxygenase-2 (COX-2) inhibitor compared with de xamethasone in a survival study of rats with intracerebral 9L gliosarcomas. (11772429)	Portnow J.... Carson K.	2002	PTGS2
9	Genetic profile of gliosarcomas. (10666371)	Reis R.M.... Ohgaki H.	2000	CDK4, TP53, EGF
10	In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. (9628761)	Leff S.E.... Mandel R.J.	1998	GCH1
11	Gliosarcoma. A study of 13 tumors, including p53 and CD34 immunohistochemistry. (9126039)	Sreenan J.J.... Prayson R.A.	1997	TP53
12	A clinical and pathological study of gliosarcoma (9275662)	Li N.... Ma H.	1996	GFAP
13	Clinicopathologic features of primary and postirradiation cerebral gliosarcoma. (7773942)	Perry J.R.... Muller P.J.	1995	ACTC1
14	A rat glioma model, CNS-1, with invasive characterist ics similar to those of human gliomas: a comparison to 9L gliosarcoma. (7760095)	Kruse C.A.... Hickey W.F.	1994	S100B, VIM, ENO2
15	Distribution of p53 protein expression in gliosarcomas: an immunohistochemical study. (8382897)	Albrecht S.... Bruner J.M.	1993	TP53
16	Gliosarcoma with features of chondroblastic osteosarc oma. (8334639)	Hayashi K.... Namba S.	1993	GFAP
17	Epithelial and melanoma antigens in gliosarcoma. An immunohistochemical study. (1594490)	Gottschalk J.... Schreiner C.	1992	KITLG, GFAP
18	Spindle-cell glioblastoma or gliosarcoma? (1653908)	Jones H.... Weller R.O.	1991	S100B, GFAP
19	Gliosarcoma: a histologic and immunohistochemical reaffirmation. (2155418)	Meis J.M.... Nelson J.S.	1990	GFAP
20	Gliosarcoma of the posterior fossa with features of a malignant fibrous histiocytoma. (2154322)	Ng H.K.... Poon W.S.	1990	GFAP

Genes related to gliosarcoma according to GeneCards:

(show all 29)

id	Symbol	Description	Score	GeneCards Section Context
1	GFAP	glial fibrillary acidic protein	11.0	Publications
2	CCND3	cyclin D3	11.0	Functions
3	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
4	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
5	CDK4	cyclin-dependent kinase 4	11.0	Publications
6	PTEN	phosphatase and tensin homolog	11.0	Publications
7	TKT	transketolase	11.0
8	TFRC	transferrin receptor (p90, CD71)	11.0
9	EPHB6	EPH receptor B6	11.0	Expressions
10	STOML3	stomatin (EPB72)-like 3	11.0
11	MSI1	musashi homolog 1 (Drosophila)	11.0	Publications
12	CPA4	carboxypeptidase A4	11.0
13	GCH1	GTP cyclohydrolase 1	11.0	Publications
14	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
15	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
16	S100B	S100 calcium binding protein B	11.0	Publications
17	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
18	BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	11.0
19	KITLG	KIT ligand	11.0	Publications
20	RB1	retinoblastoma 1	11.0	Publications
21	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
22	VIM	vimentin	11.0	Publications
23	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
24	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications
25	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
26	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
27	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
28	EGF	epidermal growth factor	11.0	Publications
29	TP53	tumor protein p53	11.0	Publications

Pathways related to gliosarcoma according to GeneDecks:

(show top 50)    (show all 80)

id	Pathway	Score	Top Affiliating Genes
1	14-3-3 Induced Intracellular Signaling36	10.0	EPHB6, PDGFRB, PDGFRA, KITLG
2	Breast Cancer Regulation by Stathmin136	9.9	EGF, EPHB6
3	Akt Signaling36	9.8	EPHB6, PDGFRB, PDGFRA, CCND3, KIT
4	Activation of cAMP-Dependent PKA36	9.7	EPHB6, PDGFRB, PDGFRA, KITLG
5	Pathway_PA16595942534	9.6	PDGFRB, BRAF, KIT
6	Transcription P53 signaling pathway10	9.6	CDKN2A, TP53
7	Endothelin-1 Signaling Pathway36	9.5	EPHB6, PDGFRB, PDGFRA, BRAF, KIT
8	p53 signaling pathway20	9.3	CDKN2A, CDK4, CCND3, TP53, PTEN
9	Small cell lung cancer20	9.2	PTGS2, PTEN, TP53, CDK4, RB1
10	Ras Pathway36	9.2	EPHB6, EGF, BRAF, KIT
11	G1-S Phase Transition36	9.2	TP53, CCND3, CDK4, CDKN2A, RB1
12	Cyclins and Cell Cycle Regulation36	9.1	TP53, CCND3, CDK4, CDKN2A, RB1
13	Cell cycle20	9.0	TP53, CCND3, CDK4, CDKN2A, RB1
14	Telomerase Components in Cell Signaling36	9.0	PDGFRB, PDGFRA, TP53, RB1, KITLG, KIT
15	Focal adhesion20	8.9	EGF, PDGFRB, PDGFRA, PTEN, CCND3, BRAF
16	Inhibition of Ribosome Biogenesis by p14(ARF)36	8.9	RB1, CDKN2A, TP53
17	Chronic myeloid leukemia20	8.9	TP53, CDK4, CDKN2A, BRAF, RB1
18	Endometrial cancer20	8.9	EGF, PTEN, TP53, BRAF
19	P2Y Receptor Signaling36	8.8	EPHB6, EGF, PDGFRB, PDGFRA, BRAF, KIT
20	Pathways in cancer20	8.7	EGF, PDGFRA, PTEN, TP53, CDK4, RB1
21	Paxillin Interactions36	8.7	EPHB6, EGF, PDGFRB, PDGFRA, KITLG, KIT
22	Non-small cell lung cancer20	8.7	EGF, CDK4, CDKN2A, BRAF, RB1
23	Cell Cycle / Checkpoint Control3	8.6	TP53, CCND3, MGMT, CDK4, CDKN2A, RB1
24	Glioblastoma Multiforme36	8.6	TP53, PTEN, PDGFRA, PDGFRB, MGMT, CDK4
25	eNOS Signaling36	8.6	EPHB6, EGF, PDGFRB, PDGFRA, KITLG, KIT
26	eIF2 Pathway36	8.6	EGF, PDGFRB, PDGFRA, BRAF, KITLG, KIT
27	NFAT in Immune Response36	8.6	EPHB6, EGF, PDGFRB, PDGFRA, KITLG, KIT
28	Nanog in Mammalian ESC Pluripotency36	8.5	EPHB6, EGF, PDGFRB, PDGFRA, BRAF, KITLG
29	GSK3 Signaling36	8.5	EPHB6, EGF, PDGFRB, PDGFRA, KITLG, KIT
30	Apoptotic Pathways in Synovial Fibroblasts36	8.5	EGF, PDGFRB, PDGFRA, TP53, KITLG, KIT
31	Estrogen Pathway36	8.4	EPHB6, EGF, PDGFRB, PDGFRA, BRAF, KITLG
32	GPCR Pathway36	8.4	EPHB6, EGF, PDGFRB, PDGFRA, BRAF, KITLG
33	JAK-STAT Pathway36	8.4	KIT, KITLG, PDGFRA, PDGFRB, EGF, EPHB6
34	JNK Pathway36	8.4	EGF, PDGFRB, PDGFRA, TP53, KITLG, KIT
35	ERK Signaling36	8.4	EPHB6, EGF, PDGFRB, PDGFRA, BRAF, KITLG
36	Prostate cancer20	8.4	EGF, PDGFRB, PDGFRA, PTEN, TP53, BRAF
37	p53 Mediated Apoptosis36	8.3	EGF, PDGFRB, PDGFRA, PTEN, TP53, KITLG
38	DHA Signaling36	8.3	EGF, PDGFRB, PDGFRA, KITLG, KIT
39	Rho Family GTPases36	8.3	EPHB6, GFAP, EGF, PDGFRB, PDGFRA, VIM
40	Bladder cancer20	8.2	EGF, TP53, CDK4, CDKN2A, BRAF, RB1
41	p38 Signaling36	8.1	EPHB6, EGF, PDGFRB, PDGFRA, TP53, KITLG
42	PTEN Pathway36	8.0	EGF, PDGFRB, PDGFRA, PTEN, TP53, BRAF
43	ILK Signaling36	8.0	EPHB6, EGF, PDGFRB, PDGFRA, PTGS2, VIM
44	MAPK Signaling36	7.9	EPHB6, EGF, PDGFRB, PDGFRA, TP53, BRAF
45	Mitochondrial Apoptosis36	7.9	EGF, PDGFRB, PDGFRA, TP53, CDKN2A, KITLG
46	Cellular Apoptosis Pathway36	7.9	EGF, PDGFRB, PDGFRA, TP53, CDKN2A, KITLG
47	Molecular Mechanisms of Cancer36	7.6	EPHB6, EGF, PDGFRA, PTEN, TP53, CDK4
48	Glioma20	7.6	RB1, BRAF, CDKN2A, CDK4, TP53, PTEN
49	Melanoma20	7.6	EGF, PDGFRB, PDGFRA, PTEN, TP53, CDK4
50	Pancreatic Adenocarcinoma36	6.3	KIT, KITLG, RB1, BRAF, CDKN2A, CDK4

Compounds related to gliosarcoma according to GeneDecks:

(show top 50)    (show all 206)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.5	PDGFRB
2	ly29400232	9.7	PTGS2, GJA1, CCND3, CDKN3
3	s 10032	9.5	S100B, GFAP, ACTC1, VIM, ENO2
4	h2o232	9.4	GCH1, KITLG, GJA1, CDKN3, PDGFRB, TFRC
5	methionine32	9.1	PDGFRB, GFAP, S100B, GCH1, VIM, PTEN
6	aspartate32	9.0	GFAP, CDKN2A, BRAF, VIM, S100B
7	glucose32	8.7	ACTC1, KIT, GCH1, GJA1, S100B, BRAF
8	pkc 41232	8.6	EGF, KIT, TKT, PDGFRB, PDGFRA
9	imatinib32 34 9 9	11.5	TKT, ACTC1, PDGFRB, PDGFRA, KIT, KITLG
10	hematoxylin32	8.5	ENO2, S100B, ACTC1, VIM, KIT, CDKN2A
11	cetuximab32 34 9 9	11.4	BRAF, CDKN3, PTEN, PDGFRB, EGF, TKT
12	calcitriol32 42 9 18 9	12.3	PDGFRB, PDGFRA, TFRC, EGF, RB1, PTEN
13	estrogen32	8.3	GFAP, ACTC1, EGF, PDGFRB, PDGFRA, GJA1
14	glycogen32 18	9.2	KIT, PTEN, CCND3, ACTC1, GFAP, ENO2
15	erlotinib32 34 9 9	11.2	CDKN3, EGF, KIT, TKT, PTEN, PDGFRB
16	etoposide32 42 9 9	11.1	TKT, PTEN, RB1, S100B, CDKN3, MGMT
17	formaldehyde32 18	9.1	MGMT, VIM, RB1, KIT, S100B, CDKN3
18	bromodeoxyuridine32	7.9	EGF, GFAP, TKT, PDGFRB, GJA1, KITLG
19	cytarabine32 34 9 9	10.9	TKT, GFAP, TP53, CDKN2A, RB1, KITLG
20	calcium32 9 18 9	10.9	BRAF, KIT, KITLG, RB1, S100B, CDK4
21	cysteine32	7.9	MGMT, CDKN2A, PTEN, PDGFRB, EGF, GFAP
22	crcs32	7.8	TP53, RB1, PTEN, BRAF, MGMT, CDKN2A
23	methotrexate32 34 42 9 9	11.8	MGMT, KIT, KITLG, RB1, VIM, CDKN2A
24	gefitinib32 34 9 9	10.8	CDK4, CDKN3, VIM, PTEN, KIT, PTGS2
25	rapamycin32 42	8.6	RB1, KITLG, KIT, VIM, TKT, EGF
26	phosphatidylinositol32	7.4	RB1, CDKN3, GJA1, PDGFRA, BRAF, PDGFRB
27	agar32	7.3	VIM, BRAF, CDKN2A, CDK4, GJA1, PTEN
28	atp32	7.3	ENO2, TKT, GFAP, PDGFRB, PDGFRA, PTEN
29	alanine32	7.3	GFAP, BRAF, VIM, GJA1, S100B, KITLG
30	pd 98,05932	7.3	GFAP, PTGS2, PTEN, BRAF, GJA1, KIT
31	irinotecan32 34 9 9	9.9	CDKN2A, KIT, EGF, TP53, MGMT, BRAF
32	butyrate32	6.9	TFRC, CDKN2A, VIM, RB1, KITLG, CDKN3
33	nitric oxide32 9 18 9	9.9	CDKN2A, MGMT, S100B, GCH1, KITLG, CDK4
34	5fluorouracil32	6.9	PTEN, TP53, MGMT, RB1, CDK4, CDKN2A
35	oligonucleotide32	6.7	PDGFRB, PDGFRA, PTEN, KIT, VIM, BRAF
36	thymidine32 18	7.7	KIT, KITLG, RB1, S100B, CDK4, MGMT
37	vegf32	6.5	S100B, BRAF, KITLG, KIT, CDKN3, MGMT
38	doxorubicin32 34 9 9	9.4	CDKN2A, CDK4, MGMT, CCND3, GJA1, TP53
39	actinomycin d32	6.2	KIT, TP53, CDKN3, CDKN2A, VIM, RB1
40	dexamethasone32 42 34 9 9	10.1	ENO2, ACTC1, EGF, PTGS2, GJA1, CCND3
41	genistein32 9 18 9	9.1	TFRC, TKT, GFAP, EGF, PDGFRB, PTGS2
42	testosterone32 9 18 9	8.9	CDKN2A, RB1, CDKN3, KITLG, KIT, VIM
43	cycloheximide32	5.9	TKT, GFAP, EGF, PTGS2, PTEN, TP53
44	tyrosine32	5.8	EPHB6, TFRC, TKT, GFAP, ACTC1, EGF
45	paclitaxel32 34 9 9	8.7	KITLG, RB1, VIM, PTEN, TFRC, GFAP
46	paraffin32	5.6	KITLG, RB1, VIM, BRAF, S100B, CDKN2A
47	progesterone32 42 9 18 9	9.6	CCND3, GFAP, ENO2, MGMT, CDK4, CDKN2A
48	retinoic acid32 42 18	7.5	CDKN2A, S100B, BRAF, RB1, KITLG, KIT
49	serine32	5.3	CDKN2A, CDKN3, PDGFRB, CDK4, GJA1, TP53
50	cisplatin32 34 9 9	8.2	PDGFRB, EGF, GFAP, TKT, TFRC, KITLG

Cellular components related to gliosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic to plasma membrane	GO:031226	9.8	PDGFRB, PDGFRA
2	cytosol	GO:005829	7.1	TKT, GFAP, ACTC1, PTEN, TP53, GJA1
3	cytoplasm	GO:005737	5.8	KIT, GFAP, ACTC1, PDGFRB, PDGFRA, PTGS2
4	nucleus	GO:005634	5.7	PDGFRB, PDGFRA, PTGS2, PTEN, TP53, CCND3

Biological processes related to gliosarcoma according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	metanephric glomerular capillary formation	GO:072277	10.3	PDGFRB, PDGFRA
2	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.3	PDGFRB, PDGFRA
3	Bergmann glial cell differentiation	GO:060020	10.2	GFAP, VIM
4	cardiac myofibril assembly	GO:055003	10.2	PDGFRA, PDGFRB, ACTC1
5	positive regulation of phospholipase C activity	GO:010863	10.0	KIT, PDGFRA, PDGFRB
6	germ cell programmed cell death	GO:035234	10.0	KIT, KITLG
7	cell chemotaxis	GO:060326	10.0	KIT, PDGFRA, PDGFRB
8	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.0	KIT, PDGFRA, PDGFRB
9	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.7	KIT, PDGFRA, PDGFRB
10	G1 phase of mitotic cell cycle	GO:000080	9.5	CDK4, CDKN2A, RB1
11	positive regulation of MAP kinase activity	GO:043406	9.3	KITLG, PDGFRB, EGF
12	peptidyl-tyrosine phosphorylation	GO:018108	9.2	EGF, PDGFRB, PDGFRA, KIT
13	G1/S transition of mitotic cell cycle	GO:000082	9.0	RB1, CDKN2A, CDKN3, CDK4
14	positive regulation of cell proliferation	GO:008284	8.8	EGF, PDGFRB, PDGFRA, PTEN, CDK4, KIT
15	response to drug	GO:042493	8.6	ACTC1, PTGS2, ENO2, MGMT, CDK4
16	cell cycle arrest	GO:007050	8.5	TP53, CDKN3, CDKN2A, RB1
17	negative regulation of cell proliferation	GO:008285	8.4	PTGS2, PTEN, TP53, GJA1, CDKN3, CDKN2A
18	signal transduction	GO:007165	8.4	STOML3, EGF, PDGFRB, GJA1, CCND3, CDK4

Molecular functions related to gliosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor binding	GO:038085	9.8	PDGFRA, PDGFRB
2	protein kinase binding	GO:019901	8.7	TP53, CCND3, CDKN2A, VIM, PTEN
3	protein homodimerization activity	GO:042803	8.4	TKT, PDGFRA, PTGS2, ENO2, S100B, GCH1
4	protein binding	GO:005515	4.7	KIT, EGF, PDGFRB, PDGFRA, PTEN, TP53