MCID: GLS001
MIFTS: 61

Gliosarcoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Gliosarcoma

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Wikipedia:65 Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain... more...

MalaCards based summary: Gliosarcoma, also known as glioblastoma with sarcomatous component, is related to meningioma and sarcoma. An important gene associated with Gliosarcoma is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Angiogenesis and NF-KappaB Family Pathway. The compounds bcnu and suberoylanilide hydroxamic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are hearing/vestibular/ear and pigmentation.

Aliases & Classifications for Gliosarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 63UMLS via Orphanet
See all sources

Gliosarcoma, Aliases & Descriptions:

Name: Gliosarcoma 8 42 10 44 48 62
Glioblastoma with Sarcomatous Component 8 62
 
Sarcomatous Glioblastoma 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
gliosarcoma:
Inheritance: Sporadic; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:3071
MeSH34 D018316
NCIt39 C3796
UMLS via Orphanet63 C0206726

Related Diseases for Gliosarcoma

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Diseases related to Gliosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma30.8GFAP, PTEN, PDGFRB
2sarcoma30.8TKT, CDK4, PDGFRB, TP53
3anaplastic ependymoma30.7PTEN, GFAP
4ependymoma30.6EGFR, GFAP, MGMT
5medulloblastoma30.5CDK4, TP53, GFAP, MGMT
6giant cell glioblastoma30.5GFAP, PTEN, EGFR
7osteosarcoma30.5TP53, PDGFRB, GJA1, CDK4, TKT
8rhabdomyosarcoma30.4CDK4, GJA1, PDGFRB, TP53
9glioblastoma multiforme30.4MGMT, GFAP, EGFR, CDK4, GJA1, PDGFRB
10oligodendroglioma30.3MGMT, GFAP, PTEN, EGFR
11pilocytic astrocytoma30.1IDH1, GFAP, PTEN, PDGFRB, CDK4, MGMT
12pancreatic cancer29.9EGFR, NFKBIA, PDGFRB, MGMT
13chondrosarcoma29.7PDGFRB, NFKBIA, CDK4, FGFR1, FGFR3
14glioblastoma29.3IDH1, GFAP, PTEN, TP53, PDGFRB, GJA1
15astrocytoma29.2GJA1, NFKBIA, CDK4, EGFR, FGFR1, PDGFRB
16melanoma28.7SNAI2, TP53, PTEN, TFRC, MGMT, PDGFRB
17gliomatosis cerebri10.5PTEN, GFAP
18gemistocytic astrocytoma10.5PTEN, GFAP
19cerebritis10.5
20osteoglophonic dysplasia10.5FGFR1
21turcot syndrome10.5PTEN
22pineoblastoma10.5GFAP
23oligoastrocytoma10.5GFAP, MGMT
24thanatophoric dysplasia10.4FGFR3
25subependymal giant cell astrocytoma10.4GFAP
26tuberous sclerosis10.4GFAP, PTEN, PDGFRB
27nelson syndrome10.4PPARG
28malignant mesothelioma10.4PDGFRB, CDK4, TKT
29osteochondroma10.4FGFR3
30fgfr-related craniosynostosis syndromes10.4FGFR1, FGFR3
31jackson-weiss syndrome10.4FGFR1, FGFR3
32systemic mastocytosis10.4PDGFRB, FGFR1
33leiomyosarcoma10.4CDK4, PDGFRB, TP53
34muenke syndrome10.4FGFR3, FGFR1
35li-fraumeni syndrome10.4PTEN, TP53
36esophageal cancer10.4TP53, PDGFRB, CDK4
37infectious mononucleosis10.3FGFR1, FGFR3
38choroid plexus papilloma10.3GFAP, TP53
39crouzon syndrome10.3FGFR1, FGFR3
40hypochondroplasia10.3FGFR1, FGFR3
41achondroplasia10.3FGFR3
42skin benign neoplasm10.3FGFR3, GJA1, MGMT
43acrocephalosyndactylia10.3FGFR1, FGFR3
44brain cancer10.3MGMT, GJA1, EGFR
45bone marrow cancer10.3FGFR1, TKT, PDGFRB
46saethre-chotzen syndrome10.3FGFR1, FGFR3
47papilloma10.3TP53, GJA1, FGFR3
48developmental disabilities10.3GJA1, FGFR1, FGFR3
49lung cancer10.3PTEN, TP53, EGFR
50adult brainstem gliosarcoma10.3

Graphical network of the top 20 diseases related to Gliosarcoma:



Diseases related to gliosarcoma

Symptoms for Gliosarcoma

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Drugs & Therapeutics for Gliosarcoma

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Drug clinical trials:

Search ClinicalTrials for Gliosarcoma

Search NIH Clinical Center for Gliosarcoma

Genetic Tests for Gliosarcoma

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Anatomical Context for Gliosarcoma

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MalaCards organs/tissues related to Gliosarcoma:

32
Brain, Spinal cord, Bone, Smooth muscle, Lung, Nk cells, T cells, Thalamus, Pineal

Animal Models for Gliosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Gliosarcoma:

36 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1PPARG, GJA1, EGFR, FGFR1, FGFR3
2MP:00011869.1EGFR, SNAI2, TP53, PTEN
3MP:00053759.0PPARG, PTEN, TP53, PDGFRB, EGFR
4MP:00053718.8PTEN, TP53, GJA1, TACC3, EGFR, FGFR1
5MP:00030128.8PPARG, MGMT, TP53, GJA1, EGFR, FGFR1
6MP:00020068.6PPARG, MGMT, PTEN, TP53, TACC3, CDK4
7MP:00053678.3PPARG, PTEN, TP53, PDGFRB, CDK4, TKT
8MP:00053708.1PPARG, TFRC, PTEN, TP53, TACC3, CDK4
9MP:00053698.1PPARG, GFAP, PTEN, TP53, PDGFRB, GJA1
10MP:00028738.1PPARG, GFAP, PTEN, TP53, PDGFRB, GJA1
11MP:00053828.1PTEN, TP53, SNAI2, PDGFRB, GJA1, TACC3
12MP:00053907.9SNAI2, TP53, PTEN, PPARG, PDGFRB, GJA1
13MP:00053817.7TFRC, GFAP, PTEN, TP53, SNAI2, PDGFRB
14MP:00053897.5PPARG, PTEN, TP53, SNAI2, PDGFRB, GJA1
15MP:00053807.4PPARG, TFRC, PTEN, TP53, SNAI2, PDGFRB
16MP:00053857.4PTEN, GFAP, TFRC, PPARG, TP53, PDGFRB
17MP:00053797.4TP53, PTEN, MGMT, PPARG, SNAI2, PDGFRB
18MP:00053867.3PPARG, GFAP, PTEN, TP53, SNAI2, GJA1
19MP:00107717.2PPARG, TFRC, PTEN, TP53, SNAI2, PDGFRB
20MP:00053847.2TP53, PTEN, GFAP, TFRC, PPARG, PDGFRB
21MP:00053917.2PPARG, GFAP, PTEN, TP53, SNAI2, PDGFRB
22MP:00053977.0TP53, PTEN, IDH1, TFRC, PPARG, SNAI2
23MP:00053767.0PTEN, GFAP, IDH1, TFRC, MGMT, PPARG
24MP:00036316.7TP53, PTEN, GFAP, TFRC, PPARG, SNAI2
25MP:00053876.5TP53, PTEN, GFAP, IDH1, TFRC, PPARG
26MP:00053786.3SNAI2, TP53, PTEN, GFAP, TFRC, PPARG
27MP:00107685.9FGFR3, PPARG, MGMT, TFRC, GFAP, PTEN

Publications for Gliosarcoma

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Articles related to Gliosarcoma:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
A Nonradiated Grade II Glioma That Underwent Delayed Malignant Transformation to a Gliosarcoma with Meningeal Growth and Dissemination. (24971682)
2014
2
Temozolomide use in adult patients with gliosarcoma: an evolving clinical practice. (23266723)
2013
3
Gliosarcoma with osseous tissue: an occasional metaplastic component. (22476731)
2013
4
Intracerebral administration of heat-inactivated Staphylococcus epidermidis enhances oncolysis and prolongs survival in a 9L orthotopic gliosarcoma model. (23652608)
2013
5
De novo gliosarcoma occurring in the posterior fossa of a 11-year-old girl. (22939178)
2012
6
Campylobacteremia in stage IV gliosarcoma with bevacizumab treatment. (23882353)
2012
7
Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. (22591609)
2012
8
Gliosarcoma with prominent smooth muscle component (gliomyosarcoma): a report of 10 cases. (21393877)
2011
9
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. (21896554)
2011
10
Gliosarcoma: a study of four cases. (21139839)
2010
11
Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity. (19618114)
2010
12
An unusual case of intraventricular gliosarcoma. (19788054)
2009
13
Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy. (18635331)
2008
14
Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing. (18263945)
2008
15
Inhibitors of EGFR signaling retard cytotoxicity of fenretinide in rat gliosarcoma cells. (17577665)
2008
16
Gliosarcoma: an audit from a single institution in India of 24 post-irradiated cases over 15 years. (19052388)
2008
17
Giant infantile gliosarcoma: magnetic resonance imaging findings. (18403585)
2008
18
Gliosarcoma with primitive neuroectodermal differentiation: case report and review of the literature. (17406789)
2007
19
Gliosarcoma cell death after radiosurgery in a rat model. (16015490)
2005
20
Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy. (15362932)
2004
21
Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRI cerebral blood volume maps. (14565159)
2003
22
Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis. (12143929)
2002
23
Primary C1-2, intradural, extramedullary meningeal sarcoma with glial fibrillary acidic protein-immunoreactive components: a spinal gliosarcoma? Case report and review of the literature. (12450287)
2002
24
Effects of IFN-gamma and interleukin-1beta on major histocompatibility complex antigen and intercellular adhesion molecule-1 expression by 9L gliosarcoma: relevance to its cytolysis by alloreactive cytotoxic T lymphocytes. (12581494)
2002
25
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. (9628761)
1998
26
A clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants. (9378529)
1997
27
Induction of acquired immunity in rats that have eliminated intracranial gliosarcoma cells by the expression of herpes simplex virus-thymidine kinase gene and ganciclovir administration. (9216859)
1997
28
Postirradiated and nonirradiated gliosarcoma: immunophenotypical profile. (8951202)
1996
29
Regional differences in apoptosis in murine gliosarcoma (T9) induced by mild hyperthermia. (9044904)
1996
30
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. (8845388)
1996
31
Efficacy of intralesionally administered cisplatin-impregnated biodegradable polymer for the treatment of 9L gliosarcoma in the rat. (8938774)
1996
32
A rat glioma model, CNS-1, with invasive characteristics similar to those of human gliomas: a comparison to 9L gliosarcoma. (7760095)
1994
33
Unusual evolution and computerized tomographic appearance of a gliosarcoma. (8087741)
1994
34
Hyperthermic enhancement of high dose-rate irradiation in 9L gliosarcoma cells. (8270439)
1994
35
Synergistic effect between intraneoplastic methotrexate and radiation on experimental intracerebral rat gliosarcoma. (8008164)
1994
36
The efficacy and distribution of suramin in the treatment of the 9L gliosarcoma. (8177391)
1994
37
Oxygenation of the rat 9L gliosarcoma and the rat 13672 mammary carcinoma with various doses of a hemoglobin solution. (7994406)
1994
38
Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-penicillamine. (8145063)
1993
39
Relationship of perfusion to edema in the 9L gliosarcoma. (8410147)
1993
40
Establishment of a new cell line derived from a human gliosarcoma. (1545891)
1992
41
Decreased susceptibility of lined human gliosarcoma cells to lymphokine-activated killer cell cytolysis by gamma-interferon treatment. (2137025)
1990
42
Analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9L rat gliosarcoma: allogeneic cytotoxic T lymphocytes prevent tumor take. (2263613)
1990
43
Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system. (3289727)
1988
44
Growth of 9-L and RT-9 gliosarcoma in female rats. (3598624)
1987
45
Establishment and characterization of a cell line from a human gliosarcoma. (3019542)
1986
46
Effect of microsurgical and carbon dioxide and argon laser resection on recurrence of the intracerebral 9L rat gliosarcoma. (6420723)
1984
47
Immunogenetic and immunologic aspects of gliosarcoma growth in rats. (6604839)
1983
48
Experimental brain tumor chemotherapy: DNA damage in the rat gliosarcoma 9L treated with CCNU. (583703)
1977
49
Association of a phaeochromocytoma and cerebral gliosarcoma with neurofibromatosis. (4289271)
1967
50
Gliosarcoma in a Full-time Stillborn Foetus. (19985093)
1926

Variations for Gliosarcoma

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Expression for genes affiliated with Gliosarcoma

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Expression patterns in normal tissues for genes affiliated with Gliosarcoma

Search GEO for disease gene expression data for Gliosarcoma.

Pathways for genes affiliated with Gliosarcoma

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Pathways related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PDGFRB, FGFR1, FGFR3
2
Show member pathways
9.7NFKBIA, EGFR, FGFR1, FGFR3
39.7TP53, MGMT, CDK4
4
Show member pathways
9.7FGFR1, FGFR3, PTEN
59.7TP53, NFKBIA, CDK4
6
Show member pathways
9.6FGFR3, FGFR1, EGFR, PDGFRB
79.6FGFR3, FGFR1, EGFR, PDGFRB
89.6PDGFRB, EGFR, FGFR1, FGFR3
9
Show member pathways
9.6FGFR3, FGFR1, EGFR, PDGFRB
109.6FGFR1, EGFR, SNAI2
119.6TACC3, TP53, TACC1, NFKBIA
12
Show member pathways
9.5TACC3, MGMT, TP53, CDK4
13
Show member pathways
9.5NFKBIA, TP53, EGFR, CDK4
14
Show member pathways
9.5PDGFRB, EGFR, TP53, NFKBIA
15
Show member pathways
MAPK signaling pathway37
9.4EGFR, FGFR3, PDGFRB, FGFR1, TP53
16
Show member pathways
9.4EGFR, FGFR1, PDGFRB, FGFR3, NFKBIA
17
Show member pathways
9.3PDGFRB, PPARG, FGFR3, FGFR1, EGFR
189.3FGFR1, SNAI2, FGFR3, GFAP
199.3CDK4, NFKBIA, PDGFRB, TP53
209.3EGFR, CDK4, TP53, PTEN
21
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.2TP53, NFKBIA, PTEN, CDK4
229.2PTEN, TP53, CDK4, NFKBIA
23
Show member pathways
9.2EGFR, PDGFRB, PTEN, FGFR3, FGFR1
249.1TP53, GFAP, GJA1, CDK4, EGFR
259.1PPARG, PTEN, TKT, IDH1
26
Show member pathways
9.1FGFR1, FGFR3, NFKBIA, EGFR, TP53, PDGFRB
27
Show member pathways
9.1PDGFRB, TP53, EGFR, FGFR1, FGFR3, NFKBIA
28
Show member pathways
9.1FGFR3, NFKBIA, FGFR1, EGFR, PDGFRB, TP53
299.1PDGFRB, FGFR3, PTEN, TP53, EGFR
309.1EGFR, PTEN, TP53, SNAI2
31
Show member pathways
9.0EGFR, FGFR3, FGFR1, PTEN, TP53, NFKBIA
32
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0PTEN, NFKBIA, PDGFRB, TP53, EGFR
33
Show member pathways
8.9FGFR1, EGFR, PDGFRB, TP53, PTEN, FGFR3
34
Show member pathways
8.9EGFR, PTEN, FGFR1, TP53, FGFR3, PDGFRB
35
Show member pathways
8.9PTEN, NFKBIA, PDGFRB, EGFR, FGFR1, FGFR3
36
Show member pathways
8.9PTEN, PDGFRB, NFKBIA, FGFR3, FGFR1, EGFR
37
Show member pathways
8.9EGFR, PDGFRB, PTEN, NFKBIA, FGFR1, FGFR3
38
Show member pathways
8.9FGFR3, PTEN, FGFR1, EGFR, NFKBIA, PDGFRB
398.9NFKBIA, FGFR1, EGFR, CDK4, TP53, PTEN
40
Show member pathways
8.8CDK4, FGFR3, FGFR1, EGFR, NFKBIA, PDGFRB
418.7CDK4, PDGFRB, TP53, MGMT, PTEN, EGFR
42
Show member pathways
8.6FGFR3, FGFR1, PDGFRB, NFKBIA, PTEN, EGFR
438.6FGFR3, FGFR1, CDK4, EGFR, PDGFRB, TP53
448.6FGFR3, EGFR, CDK4, FGFR1, PTEN, TP53
45
Show member pathways
8.4FGFR1, EGFR, PTEN, PPARG, NFKBIA, PDGFRB
46
Show member pathways
8.4FGFR1, EGFR, NFKBIA, PDGFRB, SNAI2, PTEN
47
Show member pathways
8.4FGFR3, FGFR1, EGFR, TP53, NFKBIA, PDGFRB
48
Show member pathways
Signaling Pathways in Glioblastoma37
8.3CDK4, EGFR, FGFR3, FGFR1, NFKBIA, PDGFRB
498.1PPARG, PTEN, TP53, PDGFRB, FGFR3, FGFR1
50
Show member pathways
7.5PDGFRB, FGFR3, EGFR, FGFR1, CDK4, SNAI2

Compounds for genes affiliated with Gliosarcoma

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Compounds related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1bcnu449.8MGMT, GFAP, EGFR, TP53
2suberoylanilide hydroxamic acid449.7TP53, PPARG, NFKBIA, EGFR, FGFR1
3bortezomib44 50 1111.5NFKBIA, FGFR3, EGFR, TP53, PTEN
4topotecan44 1110.5MGMT, EGFR, PDGFRB, TKT, TP53
5curcumin449.3EGFR, CDK4, NFKBIA, MGMT, PPARG, TP53
6egcg449.3EGFR, CDK4, NFKBIA, PDGFRB, TP53, MGMT
7gemcitabine44 50 1111.3PDGFRB, NFKBIA, TP53, PTEN, EGFR
8thymidylate449.2TKT, EGFR, CDK4, TP53, MGMT, NFKBIA
9retinoid449.2EGFR, CDK4, NFKBIA, PPARG, TP53, GJA1
10cetuximab44 50 1111.2PTEN, PDGFRB, TKT, EGFR
11sb 20358044 6110.1CDK4, TP53, FGFR1, PPARG, GJA1, NFKBIA
12imatinib44 50 1111.1FGFR3, FGFR1, EGFR, PDGFRB, PTEN, TKT
13gefitinib44 50 1111.1TKT, PTEN, EGFR, PDGFRB, CDK4
14n acetylcysteine449.0TFRC, NFKBIA, CDK4, EGFR, TP53, PPARG
1512-o-tetradecanoylphorbol 13-acetate448.9CDK4, MGMT, FGFR1, TKT, GJA1, NFKBIA
16gf 109203x44 619.9TKT, PPARG, TFRC, NFKBIA, EGFR
17pd 98,059448.9PTEN, FGFR1, GFAP, GJA1, NFKBIA, CDK4
18etoposide44 50 61 1111.8TKT, GJA1, NFKBIA, TP53, PTEN, MGMT
19bromodeoxyuridine448.8FGFR1, GJA1, NFKBIA, PDGFRB, GFAP, TKT
20calcitriol44 61 24 1111.8CDK4, NFKBIA, PDGFRB, GJA1, PTEN, TFRC
21methionine448.7PDGFRB, GFAP, MGMT, PTEN, FGFR1, GJA1
22oligonucleotide448.6PDGFRB, TP53, FGFR3, FGFR1, CDK4, NFKBIA
23dexamethasone44 50 28 1111.6NFKBIA, TFRC, MGMT, PPARG, GFAP, FGFR3
24phosphotyrosine448.5EGFR, FGFR3, PTEN, FGFR1, TKT, CDK4
25thymidine44 249.5FGFR1, TKT, CDK4, GJA1, TFRC, GFAP
26glutamate448.5GJA1, FGFR3, TKT, TFRC, IDH1, GFAP
275fluorouracil448.5EGFR, PTEN, TP53, MGMT, NFKBIA, CDK4
28agar448.4PTEN, CDK4, EGFR, PDGFRB, GFAP, GJA1
29doxorubicin44 50 1110.4NFKBIA, MGMT, FGFR3, TFRC, CDK4, GJA1
30phosphatidylinositol448.4TFRC, EGFR, FGFR1, NFKBIA, CDK4, GJA1
31h2o2448.3GJA1, PDGFRB, TP53, PTEN, TFRC, NFKBIA
32rapamycin448.3PTEN, EGFR, PDGFRB, NFKBIA, CDK4, TKT
33glucose448.2PTEN, CDK4, FGFR1, GFAP, GJA1, MGMT
34vitamin d448.2NFKBIA, TFRC, PTEN, PPARG, CDK4, PDGFRB
35progesterone44 28 61 24 1112.1NFKBIA, PTEN, MGMT, GFAP, TP53, PDGFRB
36alanine448.0NFKBIA, TFRC, PPARG, PTEN, CDK4, GFAP
37ly294002448.0CDK4, NFKBIA, GJA1, TP53, PTEN, TFRC
38cysteine448.0GFAP, PTEN, PDGFRB, FGFR3, FGFR1, CDK4
39cycloheximide447.8PPARG, TP53, PTEN, GFAP, GJA1, NFKBIA
40paclitaxel44 50 119.8MGMT, TFRC, FGFR1, EGFR, CDK4, PDGFRB
41paraffin447.6TFRC, GFAP, PTEN, TP53, PDGFRB, GJA1
42calcium44 50 24 1110.6GFAP, PTEN, PDGFRB, GJA1, NFKBIA, CDK4
43testosterone44 61 24 1110.5CDK4, TKT, NFKBIA, GJA1, PDGFRB, PTEN
44cisplatin44 50 61 1110.5MGMT, TFRC, PTEN, TP53, PDGFRB, GJA1
45genistein44 28 61 2 24 1112.3GFAP, TFRC, MGMT, FGFR1, EGFR, PTEN
46serine447.2CDK4, GJA1, TFRC, GFAP, PTEN, TP53
47retinoic acid44 248.1FGFR1, EGFR, TKT, CDK4, NFKBIA, GJA1
48tyrosine447.1CDK4, PDGFRB, NFKBIA, TFRC, PTEN, FGFR3
49vegf446.9FGFR3, PPARG, MGMT, FGFR1, EGFR, TKT
50estrogen446.6CDK4, PPARG, NFKBIA, GJA1, PDGFRB, SNAI2

GO Terms for genes affiliated with Gliosarcoma

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Cellular components related to Gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.3TFRC, PDGFRB, FGFR1, FGFR3
2cytoplasmGO:0057377.6GFAP, PTEN, TP53, SNAI2, PDGFRB, NFKBIA
3cytosolGO:0058297.5PPARG, IDH1, GFAP, PTEN, TP53, NFKBIA
4nucleusGO:0056346.7FGFR3, PPARG, MGMT, PTEN, TP53, SNAI2

Biological processes related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.5FGFR1, FGFR3
2positive regulation of phospholipase activityGO:01051810.5FGFR1, FGFR3
3interkinetic nuclear migrationGO:02202710.4TACC1, TACC3
4MAPK cascadeGO:00016510.3FGFR3, FGFR1, EGFR
5regulation of microtubule-based processGO:03288610.3TACC1, TACC3
6positive regulation of phospholipase C activityGO:01086310.3PDGFRB, FGFR1
7digestive tract morphogenesisGO:04854610.3FGFR3, EGFR
8cytoplasmic sequestering of transcription factorGO:04299410.3NFKBIA, TACC3
9regulation of peptidyl-tyrosine phosphorylationGO:05073010.2EGFR, PDGFRB
10response to fluid shear stressGO:03440510.2PDGFRB, GJA1
11positive regulation of MAP kinase activityGO:04340610.2FGFR1, EGFR, PDGFRB
12negative regulation of macrophage derived foam cell differentiationGO:01074510.1PPARG, NFKBIA
13positive regulation of ERK1 and ERK2 cascadeGO:07037410.1PDGFRB, EGFR, FGFR3
14response to hyperoxiaGO:05509310.0CDK4, PDGFRB
15cell divisionGO:05130110.0CDK4, TACC1, SEPT14
16peptidyl-tyrosine phosphorylationGO:01810810.0PDGFRB, EGFR, FGFR1, FGFR3
17protein autophosphorylationGO:04677710.0PDGFRB, EGFR, FGFR1, FGFR3
18white fat cell differentiationGO:05087210.0SNAI2, PPARG
19regulation of tight junction assemblyGO:200081010.0GJA1, SNAI2
20response to toxic substanceGO:0096369.9CDK4, PDGFRB, MGMT
21cellular response to ionizing radiationGO:0714799.9SNAI2, TP53, MGMT
22cellular response to epidermal growth factor stimulusGO:0713649.8EGFR, SNAI2
23long-term synaptic potentiationGO:0602919.7PTEN, GFAP
24positive regulation of vasoconstrictionGO:0459079.7EGFR, GJA1
25cell migrationGO:0164779.6PTEN, PDGFRB, FGFR1
26phosphatidylinositol-mediated signalingGO:0480159.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
27fibroblast growth factor receptor signaling pathwayGO:0085439.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
28epidermal growth factor receptor signaling pathwayGO:0071739.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
29positive regulation of cell migrationGO:0303359.5EGFR, PDGFRB, SNAI2
30response to drugGO:0424939.5PPARG, MGMT, PTEN, CDK4
31negative regulation of transcription from RNA polymerase II promoterGO:0001229.4PPARG, TP53, SNAI2, FGFR1, FGFR3
32negative regulation of apoptotic processGO:0430669.4PTEN, TP53, PDGFRB, NFKBIA, EGFR
33heart developmentGO:0075079.4PPARG, PTEN, GJA1
34Fc-epsilon receptor signaling pathwayGO:0380959.3FGFR3, FGFR1, EGFR, NFKBIA, PDGFRB, PTEN
35neurotrophin TRK receptor signaling pathwayGO:0480119.3PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
36positive regulation of cell proliferationGO:0082849.2PTEN, PDGFRB, CDK4, EGFR, FGFR1, FGFR3
37innate immune responseGO:0450879.0PPARG, PTEN, PDGFRB, NFKBIA, EGFR, FGFR1

Molecular functions related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00500710.2FGFR3, FGFR1
2fibroblast growth factor bindingGO:01713410.1FGFR3, FGFR1
3protein tyrosine kinase activityGO:0047139.8FGFR3, FGFR1, EGFR, PDGFRB
4platelet-derived growth factor receptor bindingGO:0051619.6PDGFRB, PTEN
5identical protein bindingGO:0428029.4TFRC, TP53, NFKBIA, EGFR, FGFR1
6protein kinase bindingGO:0199019.3PTEN, TP53, PDGFRB, EGFR
7enzyme bindingGO:0198999.3PPARG, PTEN, TP53, NFKBIA, EGFR
8chromatin bindingGO:0036829.3PPARG, TP53, SNAI2, EGFR
9ATP bindingGO:0055248.7TP53, PDGFRB, CDK4, EGFR, FGFR1, FGFR3
10protein bindingGO:0055157.0FGFR3, PPARG, TFRC, PTEN, TP53, SEPT14

Products for genes affiliated with Gliosarcoma

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Sources for Gliosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet