MCID: GLS001
MIFTS: 61

Gliosarcoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Gliosarcoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain... more...

MalaCards: Gliosarcoma, also known as glioblastoma with a sarcomatous component, is related to glioblastoma multiforme and sarcoma. An important gene associated with Gliosarcoma is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Angiogenesis and NF-KappaB Family Pathway. The compounds bcnu and suberoylanilide hydroxamic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are hearing/vestibular/ear and pigmentation.

Aliases & Classifications for Gliosarcoma

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
gliosarcoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

gliosarcoma 8 43 10 45 49 62
glioblastoma with a sarcomatous component 8
glioblastoma with sarcomatous component 8
sarcomatous glioblastoma 43


External Ids:

Disease Ontology8 DOID:3071
MeSH35 D018316
NCIt40 C3796
SNOMED-CT via Orphanet59 35262004
UMLS via Orphanet63 C0206726

Related Diseases for Gliosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Gliosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1glioblastoma multiforme30.5GFAP, TP53, PDGFRB, GJA1, CDK4, EGFR
2sarcoma30.4PDGFRB, TKT, TP53, CDK4
3meningioma30.3GFAP, PDGFRB, PTEN
4ependymoma30.2GFAP, EGFR, MGMT
5medulloblastoma30.2TP53, MGMT, GFAP, CDK4
6osteosarcoma30.2CDK4, GJA1, TKT, PDGFRB, TP53
7anaplastic ependymoma30.1GFAP, PTEN
8giant cell glioblastoma30.0EGFR, PTEN, GFAP
9rhabdomyosarcoma30.0CDK4, GJA1, PDGFRB, TP53
10astrocytoma30.0MGMT, IDH1, GFAP, PTEN, TP53, PDGFRB
11oligodendroglioma30.0EGFR, PTEN, MGMT, GFAP
12pilocytic astrocytoma29.9MGMT, IDH1, GFAP, CDK4, PDGFRB, PTEN
13anaplastic astrocytoma29.9EGFR, CDK4, PDGFRB, TP53, PTEN, GFAP
14pancreatic cancer29.9NFKBIA, MGMT, EGFR, PDGFRB
15chondrosarcoma29.9CDK4, FGFR1, FGFR3, NFKBIA, PDGFRB
16melanoma29.6MGMT, TFRC, PTEN, TP53, SNAI2, PDGFRB
17cerebritis10.5
18adult brainstem gliosarcoma10.2
19hypoxia10.2
20neurofibromatosis10.2
21herpes simplex10.2
22meningitis10.2
23gliomatosis cerebri10.1PTEN, GFAP
24gemistocytic astrocytoma10.1GFAP, PTEN
25turcot syndrome10.1PTEN
26osteoglophonic dysplasia10.1FGFR1
27pineoblastoma10.1GFAP
28oligoastrocytoma10.1GFAP, MGMT
29thanatophoric dysplasia10.1FGFR3
30subependymal giant cell astrocytoma10.1GFAP
31osteochondroma10.1FGFR3
32tuberous sclerosis10.1PTEN, GFAP, PDGFRB
33nelson syndrome10.1PPARG
34benign mesothelioma10.1CDK4, TKT, PDGFRB
35malignant mesothelioma10.1SNAI2, CDK4, PDGFRB
36adenoiditis10.1
37adenoid cystic carcinoma10.1
38fgfr-related craniosynostosis syndromes10.1FGFR3, FGFR1
39jackson-weiss syndrome10.1FGFR3, FGFR1
40systemic mastocytosis10.1PDGFRB, FGFR1
41leiomyosarcoma10.1TP53, PDGFRB, CDK4
42muenke syndrome10.1FGFR1, FGFR3
43li-fraumeni syndrome10.1PTEN, TP53
44esophageal cancer10.1CDK4, TP53, PDGFRB
45infectious mononucleosis10.1FGFR3, FGFR1
46crouzon syndrome10.1FGFR1, FGFR3
47hypochondroplasia10.1FGFR3, FGFR1
48choroid plexus papilloma10.1TP53, GFAP
49achondroplasia10.1FGFR3
50skin benign neoplasm10.1MGMT, FGFR3, GJA1

Graphical network of the top 20 diseases related to Gliosarcoma:



Diseases related to gliosarcoma

Symptoms for Gliosarcoma

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Drugs & Therapeutics for Gliosarcoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Gliosarcoma

Search NIH Clinical Center for Gliosarcoma

Genetic Tests for Gliosarcoma

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Anatomical Context for Gliosarcoma

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33MalaCards
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MalaCards organs/tissues related to Gliosarcoma:

33
Brain, Spinal cord, Bone, Lung, Smooth muscle, Nk cells, T cells, Pineal, Thalamus

Animal Models for Gliosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Gliosarcoma:

37 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1PPARG, GJA1, EGFR, FGFR1, FGFR3
2MP:00011869.1EGFR, SNAI2, TP53, PTEN
3MP:00053759.0PPARG, PTEN, TP53, PDGFRB, EGFR
4MP:00053718.8PTEN, TP53, GJA1, TACC3, EGFR, FGFR1
5MP:00030128.8PPARG, MGMT, TP53, GJA1, EGFR, FGFR1
6MP:00020068.6PPARG, MGMT, PTEN, TP53, TACC3, CDK4
7MP:00053678.3PPARG, PTEN, TP53, PDGFRB, CDK4, TKT
8MP:00053708.1PPARG, TFRC, PTEN, TP53, TACC3, CDK4
9MP:00053698.1PPARG, GFAP, PTEN, TP53, PDGFRB, GJA1
10MP:00028738.1PPARG, GFAP, PTEN, TP53, PDGFRB, GJA1
11MP:00053828.1PTEN, TP53, SNAI2, PDGFRB, GJA1, TACC3
12MP:00053907.9SNAI2, TP53, PTEN, PPARG, PDGFRB, GJA1
13MP:00053817.7TFRC, GFAP, PTEN, TP53, SNAI2, PDGFRB
14MP:00053897.5PPARG, PTEN, TP53, SNAI2, PDGFRB, GJA1
15MP:00053807.4PPARG, TFRC, PTEN, TP53, SNAI2, PDGFRB
16MP:00053857.4PTEN, GFAP, TFRC, PPARG, TP53, PDGFRB
17MP:00053797.4TP53, PTEN, MGMT, PPARG, SNAI2, PDGFRB
18MP:00053867.3PPARG, GFAP, PTEN, TP53, SNAI2, GJA1
19MP:00107717.2PPARG, TFRC, PTEN, TP53, SNAI2, PDGFRB
20MP:00053847.2TP53, PTEN, GFAP, TFRC, PPARG, PDGFRB
21MP:00053917.2PPARG, GFAP, PTEN, TP53, SNAI2, PDGFRB
22MP:00053977.0TP53, PTEN, IDH1, TFRC, PPARG, SNAI2
23MP:00053767.0PTEN, GFAP, IDH1, TFRC, MGMT, PPARG
24MP:00036316.7TP53, PTEN, GFAP, TFRC, PPARG, SNAI2
25MP:00053876.5TP53, PTEN, GFAP, IDH1, TFRC, PPARG
26MP:00053786.3SNAI2, TP53, PTEN, GFAP, TFRC, PPARG
27MP:00107685.9FGFR3, PPARG, MGMT, TFRC, GFAP, PTEN

Publications for Gliosarcoma

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52PubMed
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Articles related to Gliosarcoma:

(show top 50)    (show all 298)
idTitleAuthorsYear
1
Temozolomide use in adult patients with gliosarcoma: an evolving clinical practice. (23266723)
2013
2
Gliosarcoma with osseous tissue: an occasional metaplastic component. (22476731)
2013
3
Intracerebral administration of heat-inactivated Staphylococcus epidermidis enhances oncolysis and prolongs survival in a 9L orthotopic gliosarcoma model. (23652608)
2013
4
De novo gliosarcoma occurring in the posterior fossa of a 11-year-old girl. (22939178)
2012
5
Campylobacteremia in stage IV gliosarcoma with bevacizumab treatment. (23882353)
2012
6
Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. (22591609)
2012
7
Gliosarcoma with prominent smooth muscle component (gliomyosarcoma): a report of 10 cases. (21393877)
2011
8
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. (21896554)
2011
9
Gliosarcoma: a study of four cases. (21139839)
2010
10
Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity. (19618114)
2010
11
An unusual case of intraventricular gliosarcoma. (19788054)
2009
12
Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy. (18635331)
2008
13
Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing. (18263945)
2008
14
Inhibitors of EGFR signaling retard cytotoxicity of fenretinide in rat gliosarcoma cells. (17577665)
2008
15
Gliosarcoma: an audit from a single institution in India of 24 post-irradiated cases over 15 years. (19052388)
2008
16
Giant infantile gliosarcoma: magnetic resonance imaging findings. (18403585)
2008
17
Gliosarcoma with primitive neuroectodermal differentiation: case report and review of the literature. (17406789)
2007
18
Gliosarcoma cell death after radiosurgery in a rat model. (16015490)
2005
19
Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy. (15362932)
2004
20
Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRI cerebral blood volume maps. (14565159)
2003
21
Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis. (12143929)
2002
22
Primary C1-2, intradural, extramedullary meningeal sarcoma with glial fibrillary acidic protein-immunoreactive components: a spinal gliosarcoma? Case report and review of the literature. (12450287)
2002
23
Effects of IFN-gamma and interleukin-1beta on major histocompatibility complex antigen and intercellular adhesion molecule-1 expression by 9L gliosarcoma: relevance to its cytolysis by alloreactive cytotoxic T lymphocytes. (12581494)
2002
24
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. (9628761)
1998
25
A clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants. (9378529)
1997
26
Induction of acquired immunity in rats that have eliminated intracranial gliosarcoma cells by the expression of herpes simplex virus-thymidine kinase gene and ganciclovir administration. (9216859)
1997
27
Postirradiated and nonirradiated gliosarcoma: immunophenotypical profile. (8951202)
1996
28
Regional differences in apoptosis in murine gliosarcoma (T9) induced by mild hyperthermia. (9044904)
1996
29
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. (8845388)
1996
30
Efficacy of intralesionally administered cisplatin-impregnated biodegradable polymer for the treatment of 9L gliosarcoma in the rat. (8938774)
1996
31
A rat glioma model, CNS-1, with invasive characteristics similar to those of human gliomas: a comparison to 9L gliosarcoma. (7760095)
1994
32
Unusual evolution and computerized tomographic appearance of a gliosarcoma. (8087741)
1994
33
Hyperthermic enhancement of high dose-rate irradiation in 9L gliosarcoma cells. (8270439)
1994
34
Synergistic effect between intraneoplastic methotrexate and radiation on experimental intracerebral rat gliosarcoma. (8008164)
1994
35
The efficacy and distribution of suramin in the treatment of the 9L gliosarcoma. (8177391)
1994
36
Oxygenation of the rat 9L gliosarcoma and the rat 13672 mammary carcinoma with various doses of a hemoglobin solution. (7994406)
1994
37
Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-penicillamine. (8145063)
1993
38
Relationship of perfusion to edema in the 9L gliosarcoma. (8410147)
1993
39
Establishment of a new cell line derived from a human gliosarcoma. (1545891)
1992
40
Sensitization of rat 9L gliosarcoma cells to low dose rate irradiation by long duration 41 degrees C hyperthermia. (2039988)
1991
41
Decreased susceptibility of lined human gliosarcoma cells to lymphokine-activated killer cell cytolysis by gamma-interferon treatment. (2137025)
1990
42
Analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9L rat gliosarcoma: allogeneic cytotoxic T lymphocytes prevent tumor take. (2263613)
1990
43
Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system. (3289727)
1988
44
Growth of 9-L and RT-9 gliosarcoma in female rats. (3598624)
1987
45
Establishment and characterization of a cell line from a human gliosarcoma. (3019542)
1986
46
Effect of microsurgical and carbon dioxide and argon laser resection on recurrence of the intracerebral 9L rat gliosarcoma. (6420723)
1984
47
Immunogenetic and immunologic aspects of gliosarcoma growth in rats. (6604839)
1983
48
Experimental brain tumor chemotherapy: DNA damage in the rat gliosarcoma 9L treated with CCNU. (583703)
1977
49
Association of a phaeochromocytoma and cerebral gliosarcoma with neurofibromatosis. (4289271)
1967
50
Gliosarcoma in a Full-time Stillborn Foetus. (19985093)
1926

Variations for Gliosarcoma

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Expression for genes affiliated with Gliosarcoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gliosarcoma

Search GEO for disease gene expression data for Gliosarcoma.

Pathways for genes affiliated with Gliosarcoma

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Sources:
50PathCards, 5Cell Signaling Technology, 53QIAGEN, 12EMD Millipore, 51PharmGKB, 57SinoBiological, 60Thomson Reuters, 61Tocris Bioscience, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 54R&D Systems
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Pathways related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PDGFRB, FGFR1, FGFR3
2
Show member pathways
9.7NFKBIA, EGFR, FGFR1, FGFR3
39.7TP53, MGMT, CDK4
4
Show member pathways
9.7FGFR1, FGFR3, PTEN
59.7TP53, NFKBIA, CDK4
6
Show member pathways
9.6FGFR3, FGFR1, EGFR, PDGFRB
79.6FGFR3, FGFR1, EGFR, PDGFRB
89.6PDGFRB, EGFR, FGFR1, FGFR3
9
Show member pathways
9.6FGFR3, FGFR1, EGFR, PDGFRB
109.6FGFR1, EGFR, SNAI2
119.6TACC3, TP53, TACC1, NFKBIA
12
Show member pathways
9.5TACC3, MGMT, TP53, CDK4
13
Show member pathways
9.5NFKBIA, TP53, EGFR, CDK4
14
Show member pathways
9.5PDGFRB, EGFR, TP53, NFKBIA
15
Show member pathways
MAPK signaling pathway38
9.4EGFR, FGFR3, PDGFRB, FGFR1, TP53
16
Show member pathways
9.4EGFR, FGFR1, PDGFRB, FGFR3, NFKBIA
17
Show member pathways
9.3PDGFRB, PPARG, FGFR3, FGFR1, EGFR
189.3FGFR1, SNAI2, FGFR3, GFAP
199.3CDK4, NFKBIA, PDGFRB, TP53
209.3EGFR, CDK4, TP53, PTEN
21
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.2TP53, NFKBIA, PTEN, CDK4
229.2PTEN, TP53, CDK4, NFKBIA
23
Show member pathways
9.2EGFR, PDGFRB, PTEN, FGFR3, FGFR1
249.1TP53, GFAP, GJA1, CDK4, EGFR
259.1PPARG, PTEN, TKT, IDH1
26
Show member pathways
9.1FGFR1, FGFR3, NFKBIA, EGFR, TP53, PDGFRB
27
Show member pathways
9.1PDGFRB, TP53, EGFR, FGFR1, FGFR3, NFKBIA
28
Show member pathways
9.1FGFR3, NFKBIA, FGFR1, EGFR, PDGFRB, TP53
299.1PDGFRB, FGFR3, PTEN, TP53, EGFR
309.1EGFR, PTEN, TP53, SNAI2
31
Show member pathways
9.0EGFR, FGFR3, FGFR1, PTEN, TP53, NFKBIA
32
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0PTEN, NFKBIA, PDGFRB, TP53, EGFR
33
Show member pathways
8.9FGFR1, EGFR, PDGFRB, TP53, PTEN, FGFR3
34
Show member pathways
8.9EGFR, PTEN, FGFR1, TP53, FGFR3, PDGFRB
35
Show member pathways
8.9PTEN, NFKBIA, PDGFRB, EGFR, FGFR1, FGFR3
36
Show member pathways
8.9PTEN, PDGFRB, NFKBIA, FGFR3, FGFR1, EGFR
37
Show member pathways
8.9EGFR, PDGFRB, PTEN, NFKBIA, FGFR1, FGFR3
38
Show member pathways
8.9FGFR3, PTEN, FGFR1, EGFR, NFKBIA, PDGFRB
398.9NFKBIA, FGFR1, EGFR, CDK4, TP53, PTEN
40
Show member pathways
8.8CDK4, FGFR3, FGFR1, EGFR, NFKBIA, PDGFRB
418.7CDK4, PDGFRB, TP53, MGMT, PTEN, EGFR
42
Show member pathways
8.6FGFR3, FGFR1, PDGFRB, NFKBIA, PTEN, EGFR
438.6FGFR3, FGFR1, CDK4, EGFR, PDGFRB, TP53
448.6FGFR3, EGFR, CDK4, FGFR1, PTEN, TP53
45
Show member pathways
8.4FGFR1, EGFR, PTEN, PPARG, NFKBIA, PDGFRB
46
Show member pathways
8.4FGFR1, EGFR, NFKBIA, PDGFRB, SNAI2, PTEN
47
Show member pathways
8.4FGFR3, FGFR1, EGFR, TP53, NFKBIA, PDGFRB
48
Show member pathways
Signaling Pathways in Glioblastoma38
8.3CDK4, EGFR, FGFR3, FGFR1, NFKBIA, PDGFRB
498.1PPARG, PTEN, TP53, PDGFRB, FGFR3, FGFR1
50
Show member pathways
7.5PDGFRB, FGFR3, EGFR, FGFR1, CDK4, SNAI2

Compounds for genes affiliated with Gliosarcoma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1bcnu459.8MGMT, GFAP, EGFR, TP53
2suberoylanilide hydroxamic acid459.7TP53, PPARG, NFKBIA, EGFR, FGFR1
3bortezomib45 51 1111.5NFKBIA, FGFR3, EGFR, TP53, PTEN
4topotecan45 1110.5MGMT, EGFR, PDGFRB, TKT, TP53
5curcumin459.3EGFR, CDK4, NFKBIA, MGMT, PPARG, TP53
6egcg459.3EGFR, CDK4, NFKBIA, PDGFRB, TP53, MGMT
7gemcitabine45 51 1111.3PDGFRB, NFKBIA, TP53, PTEN, EGFR
8thymidylate459.2TKT, EGFR, CDK4, TP53, MGMT, NFKBIA
9retinoid459.2EGFR, CDK4, NFKBIA, PPARG, TP53, GJA1
10cetuximab45 51 1111.2PTEN, PDGFRB, TKT, EGFR
11sb 20358045 6110.1CDK4, TP53, FGFR1, PPARG, GJA1, NFKBIA
12imatinib45 51 1111.1FGFR3, FGFR1, EGFR, PDGFRB, PTEN, TKT
13gefitinib45 51 1111.1TKT, PTEN, EGFR, PDGFRB, CDK4
14n acetylcysteine459.0TFRC, NFKBIA, CDK4, EGFR, TP53, PPARG
1512-o-tetradecanoylphorbol 13-acetate458.9CDK4, MGMT, FGFR1, TKT, GJA1, NFKBIA
16gf 109203x45 619.9TKT, PPARG, TFRC, NFKBIA, EGFR
17pd 98,059458.9PTEN, FGFR1, GFAP, GJA1, NFKBIA, CDK4
18etoposide45 51 61 1111.8TKT, GJA1, NFKBIA, TP53, PTEN, MGMT
19bromodeoxyuridine458.8FGFR1, GJA1, NFKBIA, PDGFRB, GFAP, TKT
20calcitriol45 61 24 1111.8CDK4, NFKBIA, PDGFRB, GJA1, PTEN, TFRC
21methionine458.7PDGFRB, GFAP, MGMT, PTEN, FGFR1, GJA1
22oligonucleotide458.6PDGFRB, TP53, FGFR3, FGFR1, CDK4, NFKBIA
23dexamethasone45 51 29 1111.6NFKBIA, TFRC, MGMT, PPARG, GFAP, FGFR3
24phosphotyrosine458.5EGFR, FGFR3, PTEN, FGFR1, TKT, CDK4
25thymidine45 249.5FGFR1, TKT, CDK4, GJA1, TFRC, GFAP
26glutamate458.5GJA1, FGFR3, TKT, TFRC, IDH1, GFAP
275fluorouracil458.5EGFR, PTEN, TP53, MGMT, NFKBIA, CDK4
28agar458.4PTEN, CDK4, EGFR, PDGFRB, GFAP, GJA1
29doxorubicin45 51 1110.4NFKBIA, MGMT, FGFR3, TFRC, CDK4, GJA1
30phosphatidylinositol458.4TFRC, EGFR, FGFR1, NFKBIA, CDK4, GJA1
31h2o2458.3GJA1, PDGFRB, TP53, PTEN, TFRC, NFKBIA
32rapamycin458.3PTEN, EGFR, PDGFRB, NFKBIA, CDK4, TKT
33glucose458.2PTEN, CDK4, FGFR1, GFAP, GJA1, MGMT
34vitamin d458.2NFKBIA, TFRC, PTEN, PPARG, CDK4, PDGFRB
35progesterone45 29 61 24 1112.1NFKBIA, PTEN, MGMT, GFAP, TP53, PDGFRB
36alanine458.0NFKBIA, TFRC, PPARG, PTEN, CDK4, GFAP
37ly294002458.0CDK4, NFKBIA, GJA1, TP53, PTEN, TFRC
38cysteine458.0GFAP, PTEN, PDGFRB, FGFR3, FGFR1, CDK4
39cycloheximide457.8PPARG, TP53, PTEN, GFAP, GJA1, NFKBIA
40paclitaxel45 51 119.8MGMT, TFRC, FGFR1, EGFR, CDK4, PDGFRB
41paraffin457.6TFRC, GFAP, PTEN, TP53, PDGFRB, GJA1
42calcium45 51 24 1110.6GFAP, PTEN, PDGFRB, GJA1, NFKBIA, CDK4
43testosterone45 61 24 1110.5CDK4, TKT, NFKBIA, GJA1, PDGFRB, PTEN
44cisplatin45 51 61 1110.5MGMT, TFRC, PTEN, TP53, PDGFRB, GJA1
45genistein45 29 61 3 24 1112.3GFAP, TFRC, MGMT, FGFR1, EGFR, PTEN
46serine457.2CDK4, GJA1, TFRC, GFAP, PTEN, TP53
47retinoic acid45 248.1FGFR1, EGFR, TKT, CDK4, NFKBIA, GJA1
48tyrosine457.1CDK4, PDGFRB, NFKBIA, TFRC, PTEN, FGFR3
49vegf456.9FGFR3, PPARG, MGMT, FGFR1, EGFR, TKT
50estrogen456.6CDK4, PPARG, NFKBIA, GJA1, PDGFRB, SNAI2

GO Terms for genes affiliated with Gliosarcoma

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16Gene Ontology
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Cellular components related to Gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.3PDGFRB, FGFR1, FGFR3, TFRC
2cytoplasmGO:0057377.6TACC1, TACC3, EGFR, PDGFRB, IDH1, GFAP
3cytosolGO:0058297.5NFKBIA, TP53, GFAP, CDK4, TKT, FGFR1
4nucleusGO:0056346.7FGFR3, PPARG, MGMT, PTEN, TP53, SNAI2

Biological processes related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.5FGFR1, FGFR3
2positive regulation of phospholipase activityGO:01051810.5FGFR1, FGFR3
3interkinetic nuclear migrationGO:02202710.4TACC1, TACC3
4MAPK cascadeGO:00016510.3FGFR3, FGFR1, EGFR
5regulation of microtubule-based processGO:03288610.3TACC1, TACC3
6positive regulation of phospholipase C activityGO:01086310.3PDGFRB, FGFR1
7digestive tract morphogenesisGO:04854610.3FGFR3, EGFR
8cytoplasmic sequestering of transcription factorGO:04299410.3NFKBIA, TACC3
9regulation of peptidyl-tyrosine phosphorylationGO:05073010.2EGFR, PDGFRB
10response to fluid shear stressGO:03440510.2PDGFRB, GJA1
11positive regulation of MAP kinase activityGO:04340610.2FGFR1, EGFR, PDGFRB
12negative regulation of macrophage derived foam cell differentiationGO:01074510.1PPARG, NFKBIA
13positive regulation of ERK1 and ERK2 cascadeGO:07037410.1PDGFRB, EGFR, FGFR3
14response to hyperoxiaGO:05509310.0CDK4, PDGFRB
15cell divisionGO:05130110.0CDK4, TACC1, SEPT14
16peptidyl-tyrosine phosphorylationGO:01810810.0PDGFRB, EGFR, FGFR1, FGFR3
17protein autophosphorylationGO:04677710.0PDGFRB, EGFR, FGFR1, FGFR3
18white fat cell differentiationGO:05087210.0SNAI2, PPARG
19regulation of tight junction assemblyGO:200081010.0GJA1, SNAI2
20response to toxic substanceGO:0096369.9CDK4, PDGFRB, MGMT
21cellular response to ionizing radiationGO:0714799.9SNAI2, TP53, MGMT
22cellular response to epidermal growth factor stimulusGO:0713649.8EGFR, SNAI2
23long-term synaptic potentiationGO:0602919.7PTEN, GFAP
24positive regulation of vasoconstrictionGO:0459079.7EGFR, GJA1
25cell migrationGO:0164779.6PTEN, PDGFRB, FGFR1
26phosphatidylinositol-mediated signalingGO:0480159.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
27fibroblast growth factor receptor signaling pathwayGO:0085439.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
28epidermal growth factor receptor signaling pathwayGO:0071739.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
29positive regulation of cell migrationGO:0303359.5EGFR, PDGFRB, SNAI2
30response to drugGO:0424939.5PPARG, MGMT, PTEN, CDK4
31negative regulation of transcription from RNA polymerase II promoterGO:0001229.4PPARG, TP53, SNAI2, FGFR1, FGFR3
32negative regulation of apoptotic processGO:0430669.4PTEN, TP53, PDGFRB, NFKBIA, EGFR
33heart developmentGO:0075079.4PPARG, PTEN, GJA1
34Fc-epsilon receptor signaling pathwayGO:0380959.3FGFR3, FGFR1, EGFR, NFKBIA, PDGFRB, PTEN
35neurotrophin TRK receptor signaling pathwayGO:0480119.3PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
36positive regulation of cell proliferationGO:0082849.2PTEN, PDGFRB, CDK4, EGFR, FGFR1, FGFR3
37innate immune responseGO:0450879.0PPARG, PTEN, PDGFRB, NFKBIA, EGFR, FGFR1

Molecular functions related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00500710.2FGFR3, FGFR1
2fibroblast growth factor bindingGO:01713410.1FGFR3, FGFR1
3protein tyrosine kinase activityGO:0047139.8FGFR3, FGFR1, EGFR, PDGFRB
4platelet-derived growth factor receptor bindingGO:0051619.6PDGFRB, PTEN
5identical protein bindingGO:0428029.4TFRC, TP53, NFKBIA, EGFR, FGFR1
6protein kinase bindingGO:0199019.3PTEN, TP53, PDGFRB, EGFR
7enzyme bindingGO:0198999.3PPARG, PTEN, TP53, NFKBIA, EGFR
8chromatin bindingGO:0036829.3PPARG, TP53, SNAI2, EGFR
9ATP bindingGO:0055248.7TP53, PDGFRB, CDK4, EGFR, FGFR1, FGFR3
10protein bindingGO:0055157.0FGFR3, PPARG, TFRC, PTEN, TP53, SEPT14

Products for genes affiliated with Gliosarcoma

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Sources for Gliosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet