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MCID: GLS001

Gliosarcoma malady
1 drug, 20 genes, 2 tissues, 194 related diseases, clinical trials.

Summaries for Gliosarcoma

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59Wikipedia, 29MalaCards
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Wikipedia:59 Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain... more...

MalaCards: Gliosarcoma, also known as glioblastoma with a sarcomatous component, is related to astrocytoma and giant cell glioblastoma. An important gene associated with Gliosarcoma is PPARG (peroxisome proliferator-activated receptor gamma), and among its related pathways are Transcription of GFAP and S100B and Pathways in cancer. The drug carmustine and the compounds s 100 and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and t cells, and related mouse phenotypes are embryogenesis and hematopoietic system.

Aliases & Classifications for Gliosarcoma

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8Disease Ontology, 39NIH Rare Diseases, 10DISEASES, 41Novoseek, 45Orphanet, 56UMLS, 52SNOMED-CT, 31MeSH, 36NCIt
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Aliases & Descriptions:

gliosarcoma 8 39 10 41 45 56
glioblastoma with a sarcomatous component 8
glioblastoma with sarcomatous component 8
sarcomatous glioblastoma 39
glioblastoma 56



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Disease Ontology8 DOID:3071
NCIt36 C3796

Related Diseases for Gliosarcoma

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16GeneCards, 17GeneDecks
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Diseases related to gliosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma33.5CDK4, PDGFRA, PDGFRB, MGMT, GJA1, GFAP
2giant cell glioblastoma32.9PTEN, GFAP
3anaplastic astrocytoma31.8PTEN, GFAP, MGMT, PDGFRB, PDGFRA, CDK4
4meningioma31.8PDGFRB, GFAP, PTEN, S100B
5neuroblastoma31.7EPHB6, ENO2
6glioblastoma30.6PTEN, GFAP, GJA1, MGMT, PDGFRB, PDGFRA
7pilocytic astrocytoma30.5S100B, PTEN, GFAP, MGMT, PDGFRB, CDK4
8medulloblastoma30.4GFAP, MGMT, PDGFRA, ACTC1, CDK4, ENO2
9retinoblastoma30.3PPARG, GFAP, CCND3, CDK4, ENO2
10oligodendroglioma29.7PTEN, GFAP, MGMT
11leukemia29.5KITLG, TFRC, TKT, MGMT, PDGFRB, PDGFRA
12colon cancer29.4TFRC, MGMT, PDGFRB, CCND3, CDK4
13prostate cancer28.9ENO2, CDK4, PTEN
14breast cancer28.8TKT, PPARG, PTEN, GJA1, CCND3, CDK4
15t-cell leukemia28.7CDK4, CCND3, TKT, TFRC
16neurofibromatosis28.5KITLG, S100B, PDGFRA, ENO2
17hepatocellular carcinoma28.4CDK4, PDGFRA, MGMT, GJA1, PTEN
18lung cancer28.1TKT, PPARG, GJA1, MGMT, PDGFRB, PDGFRA
19pancreatitis28.1KITLG
20herpes simplex27.7CCND3, GJA1, TKT
21parkinson's disease27.7GCH1, PTEN
22myeloid leukemia27.6CDK4, TFRC, KITLG
23hemangioblastoma27.4ENO2, GFAP, S100B
24malignant glioma27.2TKT, PTEN, GFAP, GJA1, MGMT, PDGFRB
25b-cell lymphomas27.2TFRC, TKT, MGMT, CCND3, CDK4
26anaplastic oligodendroglioma27.1PTEN, GFAP, MGMT, PDGFRA, CDK4
27leiomyosarcoma26.8S100B, PDGFRB, PDGFRA, ACTC1, CDK4, ENO2
28colorectal cancer26.3TKT, PPARG, PTEN, MGMT, PDGFRB, CCND3
29melanoma26.1TFRC, KITLG, TKT, S100B, ENO2, CDK4
30adenocarcinoma26.0GJA1, PTEN, TKT, KITLG, MGMT, PDGFRB
31cerebral primitive neuroectodermal tumor13.8ENO2
32alcoholism13.8TKT
33neuroepithelioma13.8ENO2
34down syndrome13.8S100B
35merkel cell carcinoma13.8ENO2
36chronic myeloproliferative disease13.8PDGFRB
37phenylketonuria13.8GCH1
38uterine sarcoma13.8PDGFRB
39ischemia13.8GJA1, GFAP
40histiocytosis13.8S100B
41schizophrenia13.8S100B
42hepatitis13.7TFRC, TKT
43dysgerminoma13.7KITLG
44malignant mesothelioma13.7PDGFRB, CDK4
45lipoma13.7PTEN, CDK4
46esophageal cancer13.7CDK4, PDGFRB
47juvenile myelomonocytic leukemia13.7PDGFRA
48cervical cancer13.7MGMT
49amyotrophic lateral sclerosis13.7GFAP, TFRC
50hemangioma13.7ACTC1

Graphical network of the top 20 diseases related to gliosarcoma:



Diseases related to gliosarcoma

Symptoms for Gliosarcoma

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Drugs & Therapeutics for Gliosarcoma

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5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 56UMLS, 37NDF-RT
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Approved drugs:

Search CenterWatch for gliosarcoma

Drug clinical trials:

Search ClinicalTrials for gliosarcoma

Search NIH Clinical Center for gliosarcoma

Search CenterWatch for gliosarcoma

Inferred drug relations via UMLS56/NDF-RT37:

Genetic Tests for Gliosarcoma

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Anatomical Context for Gliosarcoma

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29MalaCards
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MalaCards organs/tissues related to gliosarcoma:

29
Brain, T cells

Animal Models for Gliosarcoma or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to gliosarcoma:

33 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
embryogenesis phenotype
MP:00053809.9PPARG, PDGFRB, CDK4, GJA1
2
hematopoietic system phenotype
MP:00053979.8PTEN, CDK4, GJA1, KITLG, EPHB6, PDGFRA
3
nervous system phenotype
MP:00036319.6MSI1, TFRC, TKT, STOML3, GFAP, GJA1
4
reproductive system phenotype
MP:00053899.6CDK4, PDGFRB, GJA1, PTEN, KITLG, TKT
5
tumorigenesis
MP:00020069.5PPARG, PTEN, EPHB6, KITLG, MGMT, PDGFRA
6
digestive/alimentary phenotype
MP:00053819.5PDGFRB, EPHB6, TFRC, KITLG, PDGFRA, PTEN
7
normal phenotype
MP:00028739.5S100B, PPARG, ACTC1, PDGFRA, PDGFRB, EPHB6
8
muscle phenotype
MP:00053699.5PTEN, GFAP, PPARG, CDK4, ACTC1, PDGFRA
9
liver/biliary system phenotype
MP:00053709.4KITLG, TFRC, CDK4, CCND3, PTEN, PPARG
10
vision/eye phenotype
MP:00053919.3PDGFRB, PTEN, PPARG, TKT, KITLG, CCND3
11
endocrine/exocrine gland phenotype
MP:00053799.2PPARG, MGMT, EPHB6, PDGFRA, CDK4, GJA1
12
integument phenotype
MP:00107719.2STOML3, PPARG, S100B, TFRC, KITLG, GJA1
13
skeleton phenotype
MP:00053909.1PPARG, PTEN, GJA1, MSI1, PDGFRB, EPHB6
14
renal/urinary system phenotype
MP:00053679.1PDGFRB, EPHB6, PTEN, PPARG, PDGFRA, CDK4
15
immune system phenotype
MP:00053879.1GFAP, PDGFRA, KITLG, PPARG, PTEN, GJA1
16
growth/size phenotype
MP:00053788.8CDK4, CCND3, PDGFRA, PDGFRB, EPHB6, ACTC1
17
cellular phenotype
MP:00053848.8ENO2, KITLG, TFRC, CDK4, EPHB6, PPARG
18
cardiovascular system phenotype
MP:00053858.8PDGFRB, CCND3, MSI1, PDGFRA, CDK4, GJA1
19
behavior/neurological phenotype
MP:00053868.7GJA1, TKT, STOML3, PPARG, PTEN, GFAP
20
homeostasis/metabolism phenotype
MP:00053768.6GFAP, KITLG, GJA1, TFRC, CCND3, PPARG
21
mortality/aging
MP:00107688.5MGMT, CCND3, MSI1, PDGFRA, KITLG, ACTC1

Publications for Gliosarcoma

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47PubMed
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Articles related to gliosarcoma:

(show all 23)
idTitleAuthorsYearAffiliating Genes
1Amplification of the STOML3, FREM2, and LHFP genes is associated with mesenchymal differentiation in gliosarcoma. (22538188)Nagaishi M.... Ohgaki H.2012FREM2, LHFP, STOML3
2Clinicopathologic and genomic features of gliosarcomas . (22270848)Lee D.... Nam D.H.2012IDH1, MGMT, IDH2
3A study of clinico-pathological parameters and O^6-met hylguanine DNA methyltransferase (MGMT) promoter methylation status in the progn ostication of gliosarcoma. (22380407)Singh G.... Sarkar C.2012MGMT
4O6-methylguanine DNA methyltransferase status determi ned by promoter methylation and immunohistochemistry in gliosarcoma and their c linical implications. (20556478)Kang S.H.... Chung Y.G.2011MGMT
5Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo. (19937755)deCarvalho A.C.... Mikkelsen T.2010MSI1
6Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. (19075262)Prados M.D.... Haas-Kogan D.A.2009MGMT, CDKN3
7Gliosarcoma with osteosarcomatous features: a short i llustrated review. (19399365)Charfi S.... Boudawara T.2009GFAP
8Immunohistochemistry of gliosarcoma with liposarcomatous differentiation. (18477220)Fukuda T.... Suzuki T.2008RB1
9Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas. (16373964)Reis R.M.... Lopes J.M.2005PDGFRA, PDGFRB, KIT
10Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery. (14529825)Niranjan A.... Glorioso J.C.2003GJA1
11A cyclooxygenase-2 (COX-2) inhibitor compared with de xamethasone in a survival study of rats with intracerebral 9L gliosarcomas. (11772429)Portnow J.... Carson K.2002PTGS2
12Genetic profile of gliosarcomas. (10666371)Reis R.M.... Ohgaki H.2000CDK4, TP53, PTEN
13In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. (9628761)Leff S.E.... Mandel R.J.1998GCH1
14Gliosarcoma. A study of 13 tumors, including p53 and CD34 immunohistochemistry. (9126039)Sreenan J.J.... Prayson R.A.1997TP53
15A clinical and pathological study of gliosarcoma (9275662)Li N.... Ma H.1996GFAP
16Clinicopathologic features of primary and postirradiation cerebral gliosarcoma. (7773942)Perry J.R.... Muller P.J.1995ACTC1
17A rat glioma model, CNS-1, with invasive characterist ics similar to those of human gliomas: a comparison to 9L gliosarcoma. (7760095)Kruse C.A.... Hickey W.F.1994S100B, VIM, ENO2
18Distribution of p53 protein expression in gliosarcomas: an immunohistochemical study. (8382897)Albrecht S.... Bruner J.M.1993TP53
19Gliosarcoma with features of chondroblastic osteosarc oma. (8334639)Hayashi K.... Namba S.1993GFAP
20Epithelial and melanoma antigens in gliosarcoma. An immunohistochemical study. (1594490)Gottschalk J.... Schreiner C.1992KITLG, GFAP
21Spindle-cell glioblastoma or gliosarcoma? (1653908)Jones H.... Weller R.O.1991S100B, GFAP
22Gliosarcoma: a histologic and immunohistochemical reaffirmation. (2155418)Meis J.M.... Nelson J.S.1990GFAP
23Gliosarcoma of the posterior fossa with features of a malignant fibrous histiocytoma. (2154322)Ng H.K.... Poon W.S.1990GFAP

Variations for Gliosarcoma

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Expression for genes affiliated with Gliosarcoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Gliosarcoma

Pathways for genes affiliated with Gliosarcoma

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50Reactome, 27KEGG, 54Thomson Reuters, 12EMD Millipore, 4Cell Signaling Technology, 34NCBI BioSystems Database, 48QIAGEN
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Pathways related to gliosarcoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription of GFAP and S100B50
10.2GFAP, S100B
2
Pathways in cancer27
10.2PPARG, KITLG
3
Development_Ligand-independent activation of ESR1 and ESR254
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10.2PDGFRB, PPARG
4
PDGF dimer binds two receptors simultaneously50
10.1PDGFRB, PDGFRA
5
Neuroscience4
10.0S100B, GFAP, MSI1
6
Glioma27
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9.9PTEN, PDGFRB, PDGFRA, CDK4
7
Signaling by the B Cell Receptor (BCR)50
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9.8PDGFRA, PDGFRB, PTEN, KITLG
8
Glucose / Energy Metabolism4
9.8ENO2, PTEN, PPARG, TKT
9
Glioblastoma Multiforme48
9.7PTEN, MGMT, PDGFRB, PDGFRA, CDK4
10
CREB Pathway48
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9.7PDGFRA, PDGFRB, EPHB6, PTEN, KITLG
11
PIP3 activates AKT signaling50
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9.5PDGFRA, PDGFRB, GFAP, PTEN, S100B, KITLG
12
GPCR Pathway48
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9.5KITLG, EPHB6, PDGFRB, PDGFRA, CCND3, CDK4
13
Akt Signaling48
Hide members
9.5KITLG, PTEN, EPHB6, PDGFRB, PDGFRA, CCND3
14
Rho Family GTPases48
Hide members
9.2KITLG, PTEN, GFAP, EPHB6, PDGFRB, PDGFRA

Compounds for genes affiliated with Gliosarcoma

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41Novoseek, 46PharmGKB, 11DrugBank, 55Tocris Bioscience, 22HMDB, 2BitterDB
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Compounds related to gliosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1s 1004110.2ENO2, ACTC1, GFAP, S100B
2doxorubicin41 46 1112.2GJA1, CCND3, TFRC, MGMT
3pkc 4124110.1PDGFRA, TKT, PDGFRB
4ag-12964110.1KITLG, PDGFRA, PDGFRB
5hematoxylin4110.0S100B, PTEN, ENO2, GFAP, ACTC1
6phosphatidylinositol4110.0KITLG, GJA1, CDK4, TFRC, CCND3
7benzidine4110.0TKT, TFRC, KITLG
8pd 98,0594110.0GFAP, KITLG, CDK4, GJA1, CCND3, PTEN
9tgf beta1419.9KITLG, PTEN, CDK4, PDGFRA, PDGFRB
10agar419.9KITLG, TKT, GFAP, GJA1, PDGFRB, CDK4
11ganciclovir41 1110.9TKT, KITLG, GFAP, GJA1
12cysteine419.8CDK4, TKT, PTEN, GJA1, PDGFRB, MGMT
13calcitriol41 55 11 2212.8CDK4, TFRC, PTEN, GJA1, PDGFRB, PDGFRA
14phosphotyrosine419.8PDGFRA, TKT, GJA1, PTEN, CDK4, PDGFRB
15formaldehyde41 2210.8ACTC1, MGMT, GFAP, S100B, ENO2
165fluorouracil419.8PTEN, TKT, KITLG, MGMT, PDGFRB, CDK4
17prostaglandin419.8ENO2, CDK4, GJA1, PPARG, KITLG
18methionine419.8PDGFRB, GJA1, S100B, CCND3, GCH1, MGMT
19etoposide41 46 55 1112.7PTEN, ENO2, MGMT, GJA1, S100B, TKT
20reticulin419.7S100B, GFAP, ACTC1
21iron41 2210.7S100B, KITLG, TFRC, GFAP, ACTC1, CDK4
22glycogen41 2210.7S100B, ENO2, CDK4, CCND3, ACTC1, GFAP
23ly294002419.7PPARG, TFRC, KITLG, GJA1, PTEN, CCND3
24dexamethasone41 46 55 1112.7KITLG, GJA1, GFAP, PPARG, S100B, MGMT
25progesterone41 55 11 2212.6MGMT, ENO2, CDK4, ACTC1, GJA1, PDGFRB
26bromodeoxyuridine419.6KITLG, TKT, S100B, GJA1, PDGFRB, CDK4
27lactate419.6MGMT, S100B, GFAP, TFRC, KITLG, ENO2
28dmso419.6KITLG, GJA1, TFRC, CDK4, ENO2
29creatinine419.6ACTC1, KITLG, TFRC, GFAP, TKT, ENO2
30paclitaxel41 46 1111.6KITLG, CDK4, MGMT, GJA1, GFAP, PTEN
31adenylate419.6ENO2, GJA1, GFAP, S100B, TKT, TFRC
32cycloheximide419.5TKT, GJA1, CDK4, CCND3, GFAP, KITLG
33imatinib41 46 1111.5KITLG, PDGFRB, S100B, ACTC1, CCND3, PDGFRA
34rapamycin41 5510.5TKT, TFRC, KITLG, PTEN, PDGFRB, PPARG
35genistein41 2 11 2212.4TFRC, CDK4, PDGFRB, MGMT, KITLG, GFAP
36nitric oxide41 11 2211.4CDK4, CCND3, PTEN, S100B, MGMT, GJA1
37vegf419.3ENO2, CDK4, ACTC1, PDGFRA, PDGFRB, GJA1
38thymidine41 2210.3GFAP, TFRC, KITLG, TKT, ENO2, CDK4
39oxygen41 2210.3ACTC1, PDGFRB, GCH1, GJA1, GFAP, S100B
40atp419.2ENO2, PDGFRB, S100B, TKT, GJA1, CDK4
41alanine419.2ENO2, KITLG, TFRC, PTEN, GFAP, GJA1
42serine419.2PTEN, GJA1, CDK4, PDGFRB, GCH1, GFAP
43cisplatin41 46 1111.1TFRC, TKT, KITLG, PTEN, GFAP, GJA1
44testosterone41 11 2211.1KITLG, TFRC, TKT, S100B, PTEN, GFAP
45glucose419.0GFAP, ACTC1, KITLG, S100B, PPARG, PTEN
46paraffin418.8GJA1, TFRC, KITLG, GFAP, TKT, S100B
47calcium41 46 11 2211.6MGMT, GCH1, PTEN, PDGFRB, CDK4, ACTC1
48retinoic acid41 55 2210.5TFRC, S100B, PPARG, PTEN, GJA1, MGMT
49tyrosine418.5GFAP, PTEN, S100B, TKT, KITLG, GJA1
50estrogen418.4PDGFRA, CCND3, ACTC1, CDK4, ENO2, PDGFRB

GO Terms for genes affiliated with Gliosarcoma

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15Gene Ontology
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Cellular components related to gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.2CDK4, CCND3
2intrinsic to plasma membraneGO:0312269.8PDGFRA, PDGFRB

Biological processes related to gliosarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:07227710.3PDGFRB, PDGFRA
2long-term synaptic potentiationGO:06029110.3GFAP, PTEN, S100B
3positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.3PDGFRB, PDGFRA
4positive regulation of phospholipase C activityGO:01086310.2PDGFRA, PDGFRB
5cardiac myofibril assemblyGO:05500310.2ACTC1, PDGFRA, PDGFRB
6retina vasculature development in camera-type eyeGO:06129810.0PDGFRA, PDGFRB
7phosphatidylinositol-mediated signalingGO:04801510.0PDGFRA, PDGFRB, PTEN
8positive regulation of cell proliferationGO:0082849.7S100B, PTEN, PDGFRB, PDGFRA, CDK4
9response to toxinGO:0096369.7MGMT, PDGFRB, CDK4
10signal transductionGO:0071659.5KITLG, STOML3, PPARG, GJA1, PDGFRB, CCND3

Molecular functions related to gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.1PDGFRA, PDGFRB
2vascular endothelial growth factor bindingGO:03808510.0PDGFRA, PDGFRB
3vascular endothelial growth factor-activated receptor activityGO:0050219.8PDGFRA, PDGFRB

Products for genes affiliated with Gliosarcoma

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  • Antibodies
  • Proteins
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Sources for Gliosarcoma

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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