MCID: GLS001
MIFTS: 52

Gliosarcoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Gliosarcoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 61UMLS via Orphanet
See all sources

Gliosarcoma, Aliases & Descriptions:

Name: Gliosarcoma 9 41 11 43 47 60
Glioblastoma with Sarcomatous Component 9
 
Sarcomatous Glioblastoma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
gliosarcoma:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Disease Ontology9 DOID:3071
NCIt38 C3796
MeSH33 D018316
Orphanet47 251576
UMLS via Orphanet61 C0206726

Summaries for Gliosarcoma

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Wikipedia:63 Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain... more...

MalaCards based summary: Gliosarcoma, also known as glioblastoma with sarcomatous component, is related to sarcoma and anaplastic ependymoma. An important gene associated with Gliosarcoma is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Angiogenesis and NF-KappaB Family Pathway. The compounds bcnu and suberoylanilide hydroxamic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are hearing/vestibular/ear and pigmentation.

Related Diseases for Gliosarcoma

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Diseases related to Gliosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.8TKT, CDK4, PDGFRB, TP53
2anaplastic ependymoma30.7PTEN, GFAP
3ependymoma30.6EGFR, GFAP, MGMT
4medulloblastoma30.5CDK4, TP53, GFAP, MGMT
5giant cell glioblastoma30.5GFAP, PTEN, EGFR
6rhabdomyosarcoma30.4CDK4, GJA1, PDGFRB, TP53
7glioblastoma multiforme30.4MGMT, GFAP, EGFR, CDK4, GJA1, PDGFRB
8oligodendroglioma30.3MGMT, GFAP, PTEN, EGFR
9pilocytic astrocytoma30.1IDH1, GFAP, PTEN, PDGFRB, CDK4, MGMT
10grade iii astrocytoma30.1CDK4, PDGFRB, TP53, PTEN, GFAP, MGMT
11pancreatic cancer29.8EGFR, NFKBIA, PDGFRB, MGMT
12chondrosarcoma29.7PDGFRB, NFKBIA, CDK4, FGFR1, FGFR3
13glioblastoma29.3IDH1, GFAP, PTEN, TP53, PDGFRB, GJA1
14astrocytoma29.2GJA1, NFKBIA, CDK4, EGFR, FGFR1, PDGFRB
15melanoma28.7SNAI2, TP53, PTEN, TFRC, MGMT, PDGFRB
16cerebritis10.5
17gliomatosis cerebri10.5PTEN, GFAP
18gemistocytic astrocytoma10.5PTEN, GFAP
19osteoglophonic dysplasia10.5FGFR1
20mismatch repair cancer syndrome10.5PTEN
21pineoblastoma10.5GFAP
22oligoastrocytoma10.5GFAP, MGMT
23thanatophoric dysplasia, type i10.4FGFR3
24subependymal giant cell astrocytoma10.4GFAP
25meningioma, familial10.4GFAP, PTEN, PDGFRB
26tuberous sclerosis10.4GFAP, PTEN, PDGFRB
27nelson syndrome10.4PPARG
28mesothelioma10.4PDGFRB, CDK4, TKT
29osteochondroma10.4FGFR3
30mesothelioma, somatic10.4CDK4, PDGFRB, SNAI2
31fgfr-related craniosynostosis syndromes10.4FGFR1, FGFR3
32jackson-weiss syndrome10.4FGFR1, FGFR3
33systemic mastocytosis10.4PDGFRB, FGFR1
34leiomyosarcoma10.4CDK4, PDGFRB, TP53
35muenke syndrome10.4FGFR3, FGFR1
36li-fraumeni syndrome10.3PTEN, TP53
37esophageal cancer10.3TP53, PDGFRB, CDK4
38pfeiffer syndrome10.3FGFR1, FGFR3
39choroid plexus papilloma10.3GFAP, TP53
40crouzon syndrome10.3FGFR1, FGFR3
41apert syndrome10.3FGFR1, FGFR3
42hypochondroplasia10.3FGFR1, FGFR3
43achondroplasia10.3FGFR3
44skin benign neoplasm10.3FGFR3, GJA1, MGMT
45acrocephalosyndactylia10.3FGFR1, FGFR3
46brain cancer10.3MGMT, GJA1, EGFR
47bone marrow cancer10.3FGFR1, TKT, PDGFRB
48adult brainstem gliosarcoma10.3
49saethre-chotzen syndrome10.3FGFR1, FGFR3
50papilloma10.3TP53, GJA1, FGFR3

Graphical network of the top 20 diseases related to Gliosarcoma:



Diseases related to gliosarcoma

Symptoms for Gliosarcoma

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Drugs & Therapeutics for Gliosarcoma

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Drug clinical trials:

Search ClinicalTrials for Gliosarcoma

Search NIH Clinical Center for Gliosarcoma

Genetic Tests for Gliosarcoma

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Anatomical Context for Gliosarcoma

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MalaCards organs/tissues related to Gliosarcoma:

31
Brain, Spinal cord, Bone, Smooth muscle, Lung, Nk cells, T cells, Thalamus, Pineal

Animal Models for Gliosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Gliosarcoma:

35 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1PPARG, GJA1, EGFR, FGFR1, FGFR3
2MP:00011869.1EGFR, SNAI2, TP53, PTEN
3MP:00053759.0PPARG, PTEN, TP53, PDGFRB, EGFR
4MP:00053718.8PTEN, TP53, GJA1, TACC3, EGFR, FGFR1
5MP:00030128.8PPARG, MGMT, TP53, GJA1, EGFR, FGFR1
6MP:00020068.6PPARG, MGMT, PTEN, TP53, TACC3, CDK4
7MP:00053678.3PPARG, PTEN, TP53, PDGFRB, CDK4, TKT
8MP:00053708.1PPARG, TFRC, PTEN, TP53, TACC3, CDK4
9MP:00053698.1PPARG, GFAP, PTEN, TP53, PDGFRB, GJA1
10MP:00028738.1PPARG, GFAP, PTEN, TP53, PDGFRB, GJA1
11MP:00053828.1PTEN, TP53, SNAI2, PDGFRB, GJA1, TACC3
12MP:00053907.9SNAI2, TP53, PTEN, PPARG, PDGFRB, GJA1
13MP:00053817.7TFRC, GFAP, PTEN, TP53, SNAI2, PDGFRB
14MP:00053897.5PPARG, PTEN, TP53, SNAI2, PDGFRB, GJA1
15MP:00053807.4PPARG, TFRC, PTEN, TP53, SNAI2, PDGFRB
16MP:00053857.4PTEN, GFAP, TFRC, PPARG, TP53, PDGFRB
17MP:00053797.4TP53, PTEN, MGMT, PPARG, SNAI2, PDGFRB
18MP:00053867.3PPARG, GFAP, PTEN, TP53, SNAI2, GJA1
19MP:00107717.2PPARG, TFRC, PTEN, TP53, SNAI2, PDGFRB
20MP:00053847.2TP53, PTEN, GFAP, TFRC, PPARG, PDGFRB
21MP:00053917.2PPARG, GFAP, PTEN, TP53, SNAI2, PDGFRB
22MP:00053977.0TP53, PTEN, IDH1, TFRC, PPARG, SNAI2
23MP:00053767.0PTEN, GFAP, IDH1, TFRC, MGMT, PPARG
24MP:00036316.7TP53, PTEN, GFAP, TFRC, PPARG, SNAI2
25MP:00053876.5TP53, PTEN, GFAP, IDH1, TFRC, PPARG
26MP:00053786.3SNAI2, TP53, PTEN, GFAP, TFRC, PPARG
27MP:00107685.9FGFR3, PPARG, MGMT, TFRC, GFAP, PTEN

Publications for Gliosarcoma

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Articles related to Gliosarcoma:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Cell-density-dependent manifestation of partial characteristics for neuronal precursors in a newly established human gliosarcoma cell line. (25539862)
2015
2
A Nonradiated Grade II Glioma That Underwent Delayed Malignant Transformation to a Gliosarcoma with Meningeal Growth and Dissemination. (24971682)
2014
3
Temozolomide use in adult patients with gliosarcoma: an evolving clinical practice. (23266723)
2013
4
Gliosarcoma with osseous tissue: an occasional metaplastic component. (22476731)
2013
5
Intracerebral administration of heat-inactivated Staphylococcus epidermidis enhances oncolysis and prolongs survival in a 9L orthotopic gliosarcoma model. (23652608)
2013
6
De novo gliosarcoma occurring in the posterior fossa of a 11-year-old girl. (22939178)
2012
7
Campylobacteremia in stage IV gliosarcoma with bevacizumab treatment. (23882353)
2012
8
Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. (22591609)
2012
9
Gliosarcoma with prominent smooth muscle component (gliomyosarcoma): a report of 10 cases. (21393877)
2011
10
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. (21896554)
2011
11
Gliosarcoma: a study of four cases. (21139839)
2010
12
Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity. (19618114)
2010
13
An unusual case of intraventricular gliosarcoma. (19788054)
2009
14
Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy. (18635331)
2008
15
Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing. (18263945)
2008
16
Inhibitors of EGFR signaling retard cytotoxicity of fenretinide in rat gliosarcoma cells. (17577665)
2008
17
Gliosarcoma: an audit from a single institution in India of 24 post-irradiated cases over 15 years. (19052388)
2008
18
Giant infantile gliosarcoma: magnetic resonance imaging findings. (18403585)
2008
19
Gliosarcoma with primitive neuroectodermal differentiation: case report and review of the literature. (17406789)
2007
20
Gliosarcoma cell death after radiosurgery in a rat model. (16015490)
2005
21
Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy. (15362932)
2004
22
Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRI cerebral blood volume maps. (14565159)
2003
23
Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis. (12143929)
2002
24
Primary C1-2, intradural, extramedullary meningeal sarcoma with glial fibrillary acidic protein-immunoreactive components: a spinal gliosarcoma? Case report and review of the literature. (12450287)
2002
25
Effects of IFN-gamma and interleukin-1beta on major histocompatibility complex antigen and intercellular adhesion molecule-1 expression by 9L gliosarcoma: relevance to its cytolysis by alloreactive cytotoxic T lymphocytes. (12581494)
2002
26
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. (9628761)
1998
27
A clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants. (9378529)
1997
28
Induction of acquired immunity in rats that have eliminated intracranial gliosarcoma cells by the expression of herpes simplex virus-thymidine kinase gene and ganciclovir administration. (9216859)
1997
29
Postirradiated and nonirradiated gliosarcoma: immunophenotypical profile. (8951202)
1996
30
Regional differences in apoptosis in murine gliosarcoma (T9) induced by mild hyperthermia. (9044904)
1996
31
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. (8845388)
1996
32
A rat glioma model, CNS-1, with invasive characteristics similar to those of human gliomas: a comparison to 9L gliosarcoma. (7760095)
1994
33
Unusual evolution and computerized tomographic appearance of a gliosarcoma. (8087741)
1994
34
Hyperthermic enhancement of high dose-rate irradiation in 9L gliosarcoma cells. (8270439)
1994
35
Synergistic effect between intraneoplastic methotrexate and radiation on experimental intracerebral rat gliosarcoma. (8008164)
1994
36
The efficacy and distribution of suramin in the treatment of the 9L gliosarcoma. (8177391)
1994
37
Oxygenation of the rat 9L gliosarcoma and the rat 13672 mammary carcinoma with various doses of a hemoglobin solution. (7994406)
1994
38
Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-penicillamine. (8145063)
1993
39
Relationship of perfusion to edema in the 9L gliosarcoma. (8410147)
1993
40
Establishment of a new cell line derived from a human gliosarcoma. (1545891)
1992
41
Decreased susceptibility of lined human gliosarcoma cells to lymphokine-activated killer cell cytolysis by gamma-interferon treatment. (2137025)
1990
42
Analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9L rat gliosarcoma: allogeneic cytotoxic T lymphocytes prevent tumor take. (2263613)
1990
43
Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system. (3289727)
1988
44
Growth of 9-L and RT-9 gliosarcoma in female rats. (3598624)
1987
45
Establishment and characterization of a cell line from a human gliosarcoma. (3019542)
1986
46
Effect of microsurgical and carbon dioxide and argon laser resection on recurrence of the intracerebral 9L rat gliosarcoma. (6420723)
1984
47
Immunogenetic and immunologic aspects of gliosarcoma growth in rats. (6604839)
1983
48
Experimental brain tumor chemotherapy: DNA damage in the rat gliosarcoma 9L treated with CCNU. (583703)
1977
49
Association of a phaeochromocytoma and cerebral gliosarcoma with neurofibromatosis. (4289271)
1967
50
Gliosarcoma in a Full-time Stillborn Foetus. (19985093)
1926

Variations for Gliosarcoma

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Cosmic variations for Gliosarcoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1564NRAScentral nervous system,brain,glioma,gliosarcoma1

Expression for genes affiliated with Gliosarcoma

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Search GEO for disease gene expression data for Gliosarcoma.

Pathways for genes affiliated with Gliosarcoma

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Pathways related to Gliosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PDGFRB, FGFR1, FGFR3
2
Show member pathways
9.7NFKBIA, EGFR, FGFR1, FGFR3
3
Show member pathways
9.7PTEN, FGFR1, FGFR3
49.7CDK4, NFKBIA, TP53
5
Show member pathways
9.6FGFR3, FGFR1, EGFR, PDGFRB
69.6PDGFRB, EGFR, FGFR1, FGFR3
79.6PDGFRB, EGFR, FGFR1, FGFR3
8
Show member pathways
9.6PDGFRB, EGFR, FGFR1, FGFR3
99.6FGFR1, EGFR, SNAI2
109.6TP53, NFKBIA, TACC1, TACC3
11
Show member pathways
9.5CDK4, TACC3, TP53, MGMT
12
Show member pathways
9.5EGFR, CDK4, NFKBIA, TP53
13
Show member pathways
9.5EGFR, NFKBIA, PDGFRB, TP53
14
Show member pathways
MAPK signaling pathway36
9.4FGFR3, FGFR1, EGFR, PDGFRB, TP53
15
Show member pathways
9.4FGFR3, FGFR1, EGFR, NFKBIA, PDGFRB
16
Show member pathways
9.3PPARG, PDGFRB, EGFR, FGFR1, FGFR3
179.3GFAP, SNAI2, FGFR1, FGFR3
189.3CDK4, NFKBIA, PDGFRB, TP53
199.3PTEN, TP53, CDK4, EGFR
20
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.2CDK4, NFKBIA, TP53, PTEN
219.2CDK4, NFKBIA, TP53, PTEN
22
Show member pathways
9.2PTEN, PDGFRB, EGFR, FGFR1, FGFR3
239.1EGFR, CDK4, GJA1, TP53, GFAP
249.1PPARG, IDH1, PTEN, TKT
25
Show member pathways
9.1TP53, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
26
Show member pathways
9.1TP53, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
27
Show member pathways
9.1TP53, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
289.1PTEN, TP53, PDGFRB, EGFR, FGFR3
299.1EGFR, SNAI2, TP53, PTEN
30
Show member pathways
9.0PTEN, TP53, NFKBIA, EGFR, FGFR1, FGFR3
31
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.0PTEN, TP53, PDGFRB, NFKBIA, EGFR
32
Show member pathways
8.9PTEN, TP53, PDGFRB, EGFR, FGFR1, FGFR3
33
Show member pathways
8.9PTEN, TP53, PDGFRB, EGFR, FGFR1, FGFR3
34
Show member pathways
8.9PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
35
Show member pathways
8.9PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
36
Show member pathways
8.9PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
37
Show member pathways
8.9PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
388.9PTEN, TP53, NFKBIA, CDK4, EGFR, FGFR1
39
Show member pathways
8.8TP53, PDGFRB, NFKBIA, CDK4, EGFR, FGFR1
408.7MGMT, PTEN, TP53, PDGFRB, CDK4, EGFR
41
Show member pathways
8.6GFAP, PTEN, PDGFRB, NFKBIA, EGFR, FGFR1
428.6PTEN, TP53, PDGFRB, CDK4, EGFR, FGFR1
438.6FGFR3, PTEN, TP53, PDGFRB, CDK4, EGFR
44
Show member pathways
8.4PPARG, PTEN, TP53, PDGFRB, NFKBIA, EGFR
45
Show member pathways
8.4PTEN, SNAI2, PDGFRB, NFKBIA, EGFR, FGFR1
46
Show member pathways
8.4GFAP, PTEN, TP53, PDGFRB, NFKBIA, EGFR
47
Show member pathways
Signaling Pathways in Glioblastoma36
8.3PTEN, TP53, PDGFRB, NFKBIA, CDK4, EGFR
488.1PPARG, PTEN, TP53, PDGFRB, NFKBIA, CDK4
49
Show member pathways
7.5GFAP, PTEN, TP53, SNAI2, PDGFRB, NFKBIA

Compounds for genes affiliated with Gliosarcoma

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Compounds related to Gliosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1bcnu439.8MGMT, GFAP, EGFR, TP53
2suberoylanilide hydroxamic acid439.7TP53, PPARG, NFKBIA, EGFR, FGFR1
3bortezomib43 49 1211.5NFKBIA, FGFR3, EGFR, TP53, PTEN
4topotecan43 1210.5MGMT, EGFR, PDGFRB, TKT, TP53
5curcumin439.3EGFR, CDK4, NFKBIA, MGMT, PPARG, TP53
6egcg439.3EGFR, CDK4, NFKBIA, PDGFRB, TP53, MGMT
7gemcitabine43 49 1211.3PDGFRB, NFKBIA, TP53, PTEN, EGFR
8thymidylate439.2TKT, EGFR, CDK4, TP53, MGMT, NFKBIA
9retinoid439.2EGFR, CDK4, NFKBIA, PPARG, TP53, GJA1
10cetuximab43 49 1211.2PTEN, PDGFRB, TKT, EGFR
11sb 20358043 5910.1CDK4, TP53, FGFR1, PPARG, GJA1, NFKBIA
12imatinib43 49 1211.1FGFR3, FGFR1, EGFR, PDGFRB, PTEN, TKT
13gefitinib43 49 1211.1TKT, PTEN, EGFR, PDGFRB, CDK4
14n acetylcysteine439.0TFRC, NFKBIA, CDK4, EGFR, TP53, PPARG
1512-o-tetradecanoylphorbol 13-acetate438.9CDK4, MGMT, FGFR1, TKT, GJA1, NFKBIA
16gf 109203x43 599.9TKT, PPARG, TFRC, NFKBIA, EGFR
17pd 98,059438.9PTEN, FGFR1, GFAP, GJA1, NFKBIA, CDK4
18etoposide43 49 59 1211.8TKT, GJA1, NFKBIA, TP53, PTEN, MGMT
19bromodeoxyuridine438.8FGFR1, GJA1, NFKBIA, PDGFRB, GFAP, TKT
20calcitriol43 59 24 1211.8CDK4, NFKBIA, PDGFRB, GJA1, PTEN, TFRC
21methionine438.7PDGFRB, GFAP, MGMT, PTEN, FGFR1, GJA1
22oligonucleotide438.6PDGFRB, TP53, FGFR3, FGFR1, CDK4, NFKBIA
23dexamethasone43 49 28 1211.6NFKBIA, TFRC, MGMT, PPARG, GFAP, FGFR3
24phosphotyrosine438.5EGFR, FGFR3, PTEN, FGFR1, TKT, CDK4
25thymidine43 249.5FGFR1, TKT, CDK4, GJA1, TFRC, GFAP
26glutamate438.5GJA1, FGFR3, TKT, TFRC, IDH1, GFAP
275fluorouracil438.5EGFR, PTEN, TP53, MGMT, NFKBIA, CDK4
28agar438.4PTEN, CDK4, EGFR, PDGFRB, GFAP, GJA1
29doxorubicin43 49 1210.4NFKBIA, MGMT, FGFR3, TFRC, CDK4, GJA1
30phosphatidylinositol438.4TFRC, EGFR, FGFR1, NFKBIA, CDK4, GJA1
31h2o2438.3GJA1, PDGFRB, TP53, PTEN, TFRC, NFKBIA
32rapamycin438.3PTEN, EGFR, PDGFRB, NFKBIA, CDK4, TKT
33glucose438.2PTEN, CDK4, FGFR1, GFAP, GJA1, MGMT
34vitamin d438.2NFKBIA, TFRC, PTEN, PPARG, CDK4, PDGFRB
35progesterone43 28 59 24 1212.1NFKBIA, PTEN, MGMT, GFAP, TP53, PDGFRB
36alanine438.0NFKBIA, TFRC, PPARG, PTEN, CDK4, GFAP
37ly294002438.0CDK4, NFKBIA, GJA1, TP53, PTEN, TFRC
38cysteine438.0GFAP, PTEN, PDGFRB, FGFR3, FGFR1, CDK4
39cycloheximide437.8PPARG, TP53, PTEN, GFAP, GJA1, NFKBIA
40paclitaxel43 49 129.8MGMT, TFRC, FGFR1, EGFR, CDK4, PDGFRB
41paraffin437.6TFRC, GFAP, PTEN, TP53, PDGFRB, GJA1
42calcium43 49 24 1210.6GFAP, PTEN, PDGFRB, GJA1, NFKBIA, CDK4
43testosterone43 59 24 1210.5CDK4, TKT, NFKBIA, GJA1, PDGFRB, PTEN
44cisplatin43 49 59 1210.5MGMT, TFRC, PTEN, TP53, PDGFRB, GJA1
45genistein43 28 59 2 24 1212.3GFAP, TFRC, MGMT, FGFR1, EGFR, PTEN
46serine437.2CDK4, GJA1, TFRC, GFAP, PTEN, TP53
47retinoic acid43 248.1FGFR1, EGFR, TKT, CDK4, NFKBIA, GJA1
48tyrosine437.1CDK4, PDGFRB, NFKBIA, TFRC, PTEN, FGFR3
49vegf436.9FGFR3, PPARG, MGMT, FGFR1, EGFR, TKT
50estrogen436.6CDK4, PPARG, NFKBIA, GJA1, PDGFRB, SNAI2

GO Terms for genes affiliated with Gliosarcoma

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Cellular components related to Gliosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:00160239.3TFRC, PDGFRB, FGFR1, FGFR3
2cytoplasmGO:00057377.6GFAP, PTEN, TP53, SNAI2, PDGFRB, NFKBIA
3cytosolGO:00058297.5PPARG, IDH1, GFAP, PTEN, TP53, NFKBIA
4nucleusGO:00056346.7FGFR3, PPARG, MGMT, PTEN, TP53, SNAI2

Biological processes related to Gliosarcoma according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:009008010.5FGFR1, FGFR3
2positive regulation of phospholipase activityGO:001051810.5FGFR1, FGFR3
3interkinetic nuclear migrationGO:002202710.4TACC1, TACC3
4MAPK cascadeGO:000016510.3FGFR3, FGFR1, EGFR
5regulation of microtubule-based processGO:003288610.3TACC1, TACC3
6positive regulation of phospholipase C activityGO:001086310.3PDGFRB, FGFR1
7digestive tract morphogenesisGO:004854610.3FGFR3, EGFR
8cytoplasmic sequestering of transcription factorGO:004299410.3NFKBIA, TACC3
9regulation of peptidyl-tyrosine phosphorylationGO:005073010.2EGFR, PDGFRB
10response to fluid shear stressGO:003440510.2PDGFRB, GJA1
11positive regulation of MAP kinase activityGO:004340610.2FGFR1, EGFR, PDGFRB
12negative regulation of macrophage derived foam cell differentiationGO:001074510.1PPARG, NFKBIA
13positive regulation of ERK1 and ERK2 cascadeGO:007037410.1PDGFRB, EGFR, FGFR3
14response to hyperoxiaGO:005509310.0CDK4, PDGFRB
15cell divisionGO:005130110.0CDK4, TACC1, SEPT14
16peptidyl-tyrosine phosphorylationGO:001810810.0PDGFRB, EGFR, FGFR1, FGFR3
17protein autophosphorylationGO:004677710.0PDGFRB, EGFR, FGFR1, FGFR3
18white fat cell differentiationGO:005087210.0SNAI2, PPARG
19regulation of tight junction assemblyGO:0200081010.0GJA1, SNAI2
20response to toxic substanceGO:00096369.9CDK4, PDGFRB, MGMT
21cellular response to ionizing radiationGO:00714799.9SNAI2, TP53, MGMT
22cellular response to epidermal growth factor stimulusGO:00713649.8EGFR, SNAI2
23long-term synaptic potentiationGO:00602919.7PTEN, GFAP
24positive regulation of vasoconstrictionGO:00459079.7EGFR, GJA1
25cell migrationGO:00164779.6PTEN, PDGFRB, FGFR1
26phosphatidylinositol-mediated signalingGO:00480159.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
27fibroblast growth factor receptor signaling pathwayGO:00085439.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
28epidermal growth factor receptor signaling pathwayGO:00071739.6PTEN, PDGFRB, EGFR, FGFR1, FGFR3
29positive regulation of cell migrationGO:00303359.5EGFR, PDGFRB, SNAI2
30response to drugGO:00424939.5PPARG, MGMT, PTEN, CDK4
31negative regulation of transcription from RNA polymerase II promoterGO:00001229.4PPARG, TP53, SNAI2, FGFR1, FGFR3
32negative regulation of apoptotic processGO:00430669.4PTEN, TP53, PDGFRB, NFKBIA, EGFR
33heart developmentGO:00075079.4PPARG, PTEN, GJA1
34Fc-epsilon receptor signaling pathwayGO:00380959.3FGFR3, FGFR1, EGFR, NFKBIA, PDGFRB, PTEN
35neurotrophin TRK receptor signaling pathwayGO:00480119.3PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
36positive regulation of cell proliferationGO:00082849.2PTEN, PDGFRB, CDK4, EGFR, FGFR1, FGFR3
37innate immune responseGO:00450879.0PPARG, PTEN, PDGFRB, NFKBIA, EGFR, FGFR1

Molecular functions related to Gliosarcoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.2FGFR3, FGFR1
2fibroblast growth factor bindingGO:001713410.1FGFR3, FGFR1
3protein tyrosine kinase activityGO:00047139.8FGFR3, FGFR1, EGFR, PDGFRB
4platelet-derived growth factor receptor bindingGO:00051619.6PDGFRB, PTEN
5identical protein bindingGO:00428029.4TFRC, TP53, NFKBIA, EGFR, FGFR1
6protein kinase bindingGO:00199019.3PTEN, TP53, PDGFRB, EGFR
7enzyme bindingGO:00198999.3PPARG, PTEN, TP53, NFKBIA, EGFR
8chromatin bindingGO:00036829.3PPARG, TP53, SNAI2, EGFR
9ATP bindingGO:00055248.7TP53, PDGFRB, CDK4, EGFR, FGFR1, FGFR3
10protein bindingGO:00055157.0FGFR3, PPARG, TFRC, PTEN, TP53, SEPT14

Products for genes affiliated with Gliosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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43Novoseek
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