Gliosarcoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Gliosarcoma

Sources:
⁶⁴Wikipedia, ³²MalaCards
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Wikipedia:⁶⁴ Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain... more...

MalaCards based summary: Gliosarcoma, also known as glioblastoma with sarcomatous component, is related to meningioma and sarcoma. An important gene associated with Gliosarcoma is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Angiogenesis and NF-KappaB Family Pathway. The compounds bcnu and suberoylanilide hydroxamic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are hearing/vestibular/ear and pigmentation.

Aliases & Classifications for Gliosarcoma

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁶¹UMLS, ³⁴MeSH, ⁵⁶SNOMED-CT, ³⁹NCIt, ⁶²UMLS via Orphanet
See all sources

Gliosarcoma, Aliases & Descriptions:

Name: Gliosarcoma ⁹ ⁴² ¹¹ ⁴⁴ ⁴⁸ ⁶¹

Glioblastoma with Sarcomatous Component ⁹ ⁶¹

Sarcomatous Glioblastoma ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases

Orphanet: ⁴⁸

Rare neurological diseases

Rare tumors

Characteristics (Orphanet epidemiological data):

⁴⁸

gliosarcoma:
Inheritance: Sporadic; Age of onset: Adulthood

External Ids:

Disease Ontology⁹ DOID:3071

MeSH³⁴ D018316

SNOMED-CT⁵⁶ 189918008, 35262004, 189909006

NCIt³⁹ C3796

UMLS via Orphanet⁶² C0206726

UMLS⁶¹ C0206726

Related Diseases for Gliosarcoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Gliosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 120)

id	Related Disease	Score	Top Affiliating Genes
1	meningioma	30.8	GFAP, PDGFRB, PTEN
2	sarcoma	30.8	PDGFRB, TKT, TP53, CDK4
3	anaplastic ependymoma	30.7	GFAP, PTEN
4	ependymoma	30.6	GFAP, EGFR, MGMT
5	medulloblastoma	30.5	TP53, MGMT, GFAP, CDK4
6	giant cell glioblastoma	30.5	EGFR, PTEN, GFAP
7	osteosarcoma	30.5	CDK4, GJA1, TKT, PDGFRB, TP53
8	rhabdomyosarcoma	30.4	CDK4, GJA1, PDGFRB, TP53
9	glioblastoma multiforme	30.4	GFAP, TP53, PDGFRB, GJA1, CDK4, EGFR
10	oligodendroglioma	30.3	EGFR, PTEN, MGMT, GFAP
11	pilocytic astrocytoma	30.1	MGMT, IDH1, GFAP, CDK4, PDGFRB, PTEN
12	pancreatic cancer	29.9	NFKBIA, MGMT, EGFR, PDGFRB
13	chondrosarcoma	29.7	CDK4, FGFR1, FGFR3, NFKBIA, PDGFRB
14	glioblastoma	29.3	TP53, PDGFRB, GJA1, NFKBIA, CDK4, TKT
15	astrocytoma	29.2	MGMT, IDH1, GFAP, PTEN, TP53, PDGFRB
16	melanoma	28.7	MGMT, TFRC, PTEN, TP53, SNAI2, PDGFRB
17	gliomatosis cerebri	10.5	PTEN, GFAP
18	gemistocytic astrocytoma	10.5	GFAP, PTEN
19	cerebritis	10.5
20	turcot syndrome	10.5	PTEN
21	osteoglophonic dysplasia	10.5	FGFR1
22	pineoblastoma	10.5	GFAP
23	oligoastrocytoma	10.5	GFAP, MGMT
24	thanatophoric dysplasia	10.4	FGFR3
25	subependymal giant cell astrocytoma	10.4	GFAP
26	tuberous sclerosis	10.4	PTEN, GFAP, PDGFRB
27	osteochondroma	10.4	FGFR3
28	nelson syndrome	10.4	PPARG
29	malignant mesothelioma	10.4	CDK4, TKT, PDGFRB
30	fgfr-related craniosynostosis syndromes	10.4	FGFR3, FGFR1
31	jackson-weiss syndrome	10.4	FGFR3, FGFR1
32	systemic mastocytosis	10.4	PDGFRB, FGFR1
33	leiomyosarcoma	10.4	TP53, PDGFRB, CDK4
34	muenke syndrome	10.4	FGFR1, FGFR3
35	li-fraumeni syndrome	10.4	PTEN, TP53
36	esophageal cancer	10.4	CDK4, TP53, PDGFRB
37	infectious mononucleosis	10.3	FGFR3, FGFR1
38	crouzon syndrome	10.3	FGFR1, FGFR3
39	hypochondroplasia	10.3	FGFR3, FGFR1
40	choroid plexus papilloma	10.3	TP53, GFAP
41	achondroplasia	10.3	FGFR3
42	skin benign neoplasm	10.3	MGMT, FGFR3, GJA1
43	acrocephalosyndactylia	10.3	FGFR1, FGFR3
44	brain cancer	10.3	MGMT, EGFR, GJA1
45	bone marrow cancer	10.3	PDGFRB, TKT, FGFR1
46	saethre-chotzen syndrome	10.3	FGFR1, FGFR3
47	papilloma	10.3	FGFR3, GJA1, TP53
48	developmental disabilities	10.3	FGFR1, GJA1, FGFR3
49	lung cancer	10.3	PTEN, EGFR, TP53
50	adult brainstem gliosarcoma	10.3

Graphical network of the top 20 diseases related to Gliosarcoma:

Symptoms for Gliosarcoma

Drugs & Therapeutics for Gliosarcoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Gliosarcoma

Search NIH Clinical Center for Gliosarcoma

Genetic Tests for Gliosarcoma

Anatomical Context for Gliosarcoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Gliosarcoma:

³²

Brain, Spinal cord, Bone, Smooth muscle, Lung, Nk cells, T cells, Thalamus, Pineal

Animal Models for Gliosarcoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Gliosarcoma:

³⁶ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	9.1	PPARG, GJA1, EGFR, FGFR1, FGFR3
2	pigmentation phenotype	MP:0001186	9.1	EGFR, SNAI2, TP53, PTEN
3	adipose tissue phenotype	MP:0005375	9.0	PPARG, PTEN, TP53, PDGFRB, EGFR
4	limbs/digits/tail phenotype	MP:0005371	8.8	PTEN, TP53, GJA1, TACC3, EGFR, FGFR1
5	no phenotypic analysis	MP:0003012	8.8	PPARG, MGMT, TP53, GJA1, EGFR, FGFR1
6	tumorigenesis	MP:0002006	8.6	PPARG, MGMT, PTEN, TP53, TACC3, CDK4
7	renal/urinary system phenotype	MP:0005367	8.3	PPARG, PTEN, TP53, PDGFRB, CDK4, TKT
8	liver/biliary system phenotype	MP:0005370	8.1	PPARG, TFRC, PTEN, TP53, TACC3, CDK4
9	muscle phenotype	MP:0005369	8.1	PPARG, GFAP, PTEN, TP53, PDGFRB, GJA1
10	normal phenotype	MP:0002873	8.1	PPARG, GFAP, PTEN, TP53, PDGFRB, GJA1
11	craniofacial phenotype	MP:0005382	8.1	PTEN, TP53, SNAI2, PDGFRB, GJA1, TACC3
12	skeleton phenotype	MP:0005390	7.9	SNAI2, TP53, PTEN, PPARG, PDGFRB, GJA1
13	digestive/alimentary phenotype	MP:0005381	7.7	TFRC, GFAP, PTEN, TP53, SNAI2, PDGFRB
14	reproductive system phenotype	MP:0005389	7.5	PPARG, PTEN, TP53, SNAI2, PDGFRB, GJA1
15	embryogenesis phenotype	MP:0005380	7.4	PPARG, TFRC, PTEN, TP53, SNAI2, PDGFRB
16	cardiovascular system phenotype	MP:0005385	7.4	PTEN, GFAP, TFRC, PPARG, TP53, PDGFRB
17	endocrine/exocrine gland phenotype	MP:0005379	7.4	TP53, PTEN, MGMT, PPARG, SNAI2, PDGFRB
18	behavior/neurological phenotype	MP:0005386	7.3	PPARG, GFAP, PTEN, TP53, SNAI2, GJA1
19	integument phenotype	MP:0010771	7.2	PPARG, TFRC, PTEN, TP53, SNAI2, PDGFRB
20	cellular phenotype	MP:0005384	7.2	TP53, PTEN, GFAP, TFRC, PPARG, PDGFRB
21	vision/eye phenotype	MP:0005391	7.2	PPARG, GFAP, PTEN, TP53, SNAI2, PDGFRB
22	hematopoietic system phenotype	MP:0005397	7.0	TP53, PTEN, IDH1, TFRC, PPARG, SNAI2
23	homeostasis/metabolism phenotype	MP:0005376	7.0	PTEN, GFAP, IDH1, TFRC, MGMT, PPARG
24	nervous system phenotype	MP:0003631	6.7	TP53, PTEN, GFAP, TFRC, PPARG, SNAI2
25	immune system phenotype	MP:0005387	6.5	TP53, PTEN, GFAP, IDH1, TFRC, PPARG
26	growth/size/body phenotype	MP:0005378	6.3	SNAI2, TP53, PTEN, GFAP, TFRC, PPARG
27	mortality/aging	MP:0010768	5.9	FGFR3, PPARG, MGMT, TFRC, GFAP, PTEN

Publications for Gliosarcoma

Sources:
⁵¹PubMed
See all sources

Articles related to Gliosarcoma:

(show top 50) (show all 305)

id	Title	Authors	Year
1	A Nonradiated Grade II Glioma That Underwent Delayed Malignant Transformation to a Gliosarcoma with Meningeal Growth and Dissemination. (24971682)	Rech F.... Duffau H.	2014
2	Temozolomide use in adult patients with gliosarcoma: an evolving clinical practice. (23266723)	Walker G.V.... McAleer M.F.	2013
3	Gliosarcoma with osseous tissue: an occasional metaplastic component. (22476731)	Tyagi I.... Batra V.V.	2013
4	Intracerebral administration of heat-inactivated Staphylococcus epidermidis enhances oncolysis and prolongs survival in a 9L orthotopic gliosarcoma model. (23652608)	LAPhr M.... Hampl J.A.	2013
5	De novo gliosarcoma occurring in the posterior fossa of a 11-year-old girl. (22939178)	Chikkannaiah P.... Santosh V.	2012
6	Campylobacteremia in stage IV gliosarcoma with bevacizumab treatment. (23882353)	Liu P.	2012
7	Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. (22591609)	Masi B.C.... Cima M.J.	2012
8	Gliosarcoma with prominent smooth muscle component (gliomyosarcoma): a report of 10 cases. (21393877)	Khanna M.... Roy S.	2011
9	Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. (21896554)	Butowski N.... Prados M.D.	2011
10	Gliosarcoma: a study of four cases. (21139839)	GA1ney Y.... Andrieu M.N.	2010
11	Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity. (19618114)	Han S.J.... Parsa A.T.	2010
12	An unusual case of intraventricular gliosarcoma. (19788054)	Govindan A.... Shankar S.K.	2009
13	Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy. (18635331)	RAcgnard P.... Le Duc G.	2008
14	Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing. (18263945)	Regnard P.... Bravin A.	2008
15	Inhibitors of EGFR signaling retard cytotoxicity of fenretinide in rat gliosarcoma cells. (17577665)	Zaheer A.... Traynelis V.C.	2008
16	Gliosarcoma: an audit from a single institution in India of 24 post-irradiated cases over 15 years. (19052388)	Kumar P.... Datta N.R.	2008
17	Giant infantile gliosarcoma: magnetic resonance imaging findings. (18403585)	Sanal H.T.... Chen L.	2008
18	Gliosarcoma with primitive neuroectodermal differentiation: case report and review of the literature. (17406789)	Kaplan K.J.... Perry A.	2007
19	Gliosarcoma cell death after radiosurgery in a rat model. (16015490)	Psarros T.G.... Willis M.S.	2005
20	Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy. (15362932)	Moriyama E.H.... Wilson B.C.	2004
21	Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRI cerebral blood volume maps. (14565159)	Badruddoja M.A.... Schmainda K.M.	2003
22	Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis. (12143929)	Kepes J.J.	2002
23	Primary C1-2, intradural, extramedullary meningeal sarcoma with glial fibrillary acidic protein-immunoreactive components: a spinal gliosarcoma? Case report and review of the literature. (12450287)	Barbagallo G.M.... Albanese V.	2002
24	Effects of IFN-gamma and interleukin-1beta on major histocompatibility complex antigen and intercellular adhesion molecule-1 expression by 9L gliosarcoma: relevance to its cytolysis by alloreactive cytotoxic T lymphocytes. (12581494)	Schiltz P.M.... Kruse C.A.	2002
25	In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. (9628761)	Leff S.E.... Mandel R.J.	1998
26	A clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants. (9378529)	Sarkar C.... Varma A.	1997
27	Induction of acquired immunity in rats that have eliminated intracranial gliosarcoma cells by the expression of herpes simplex virus-thymidine kinase gene and ganciclovir administration. (9216859)	Iwadate Y.... Sakiyama S.	1997
28	Postirradiated and nonirradiated gliosarcoma: immunophenotypical profile. (8951202)	Ang L.C.... Nelson N.	1996
29	Regional differences in apoptosis in murine gliosarcoma (T9) induced by mild hyperthermia. (9044904)	Moroi J.... Yamaguchi K.	1996
30	Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. (8845388)	Cool V.... Velu T.	1996
31	Efficacy of intralesionally administered cisplatin-impregnated biodegradable polymer for the treatment of 9L gliosarcoma in the rat. (8938774)	Lillehei K.O.... Kleinschmidt-DeMasters B.	1996
32	A rat glioma model, CNS-1, with invasive characteristics similar to those of human gliomas: a comparison to 9L gliosarcoma. (7760095)	Kruse C.A.... Hickey W.F.	1994
33	Unusual evolution and computerized tomographic appearance of a gliosarcoma. (8087741)	Preul M.C.... Carpenter S.	1994
34	Hyperthermic enhancement of high dose-rate irradiation in 9L gliosarcoma cells. (8270439)	Armour E.P.... Martinez A.	1994
35	Synergistic effect between intraneoplastic methotrexate and radiation on experimental intracerebral rat gliosarcoma. (8008164)	Wilkinson H.A.... Rosenfeld S.	1994
36	The efficacy and distribution of suramin in the treatment of the 9L gliosarcoma. (8177391)	Olson J.J.... Reisner A.	1994
37	Oxygenation of the rat 9L gliosarcoma and the rat 13672 mammary carcinoma with various doses of a hemoglobin solution. (7994406)	Teicher B.A.... Menon K.	1994
38	Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-penicillamine. (8145063)	Yoshida D.... Nakazawa S.	1993
39	Relationship of perfusion to edema in the 9L gliosarcoma. (8410147)	Steen R.G.... Graham M.M.	1993
40	Establishment of a new cell line derived from a human gliosarcoma. (1545891)	Iwasaki K.... Oda Y.	1992
41	Decreased susceptibility of lined human gliosarcoma cells to lymphokine-activated killer cell cytolysis by gamma-interferon treatment. (2137025)	Miyatake S.... Aoki T.	1990
42	Analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9L rat gliosarcoma: allogeneic cytotoxic T lymphocytes prevent tumor take. (2263613)	Kruse C.A.... Bellgrau D.	1990
43	Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system. (3289727)	Wargotz E.S.... Jannotta F.S.	1988
44	Growth of 9-L and RT-9 gliosarcoma in female rats. (3598624)	Furuta T.... Fujiwara T.	1987
45	Establishment and characterization of a cell line from a human gliosarcoma. (3019542)	Rutka J.T.... Rosenblum M.L.	1986
46	Effect of microsurgical and carbon dioxide and argon laser resection on recurrence of the intracerebral 9L rat gliosarcoma. (6420723)	Edwards M.S.... Davis R.L.	1984
47	Immunogenetic and immunologic aspects of gliosarcoma growth in rats. (6604839)	Geyer S.J.... Landay A.	1983
48	Experimental brain tumor chemotherapy: DNA damage in the rat gliosarcoma 9L treated with CCNU. (583703)	Gutin P.H.... Walker M.D.	1977
49	Association of a phaeochromocytoma and cerebral gliosarcoma with neurofibromatosis. (4289271)	Roberts A.H.	1967
50	Gliosarcoma in a Full-time Stillborn Foetus. (19985093)	Malan D.J.	1926

Genes related to Gliosarcoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals, ⁴⁸Orphanet
See all sources

Genes related to Gliosarcoma:

(show all 23)

- Elite gene

id	Symbol	Description	Score	Implication
1	FGFR3	fibroblast growth factor receptor 3	20.00	Gene fusion ⁴⁸
2	FGFR1	fibroblast growth factor receptor 1	19.13	Gene fusion ⁴⁸
3	EGFR	epidermal growth factor receptor	18.26	Gene fusion ⁴⁸
4	LZTR1	leucine-zipper-like transcription regulator 1	17.39	Causative somatic mutation ⁴⁸
5	TACC3	transforming, acidic coiled-coil containing protein 3	16.52	Gene fusion ⁴⁸
6	TACC1	transforming, acidic coiled-coil containing protein 1	15.65	Gene fusion ⁴⁸
7	SEPT14	septin 14	14.78	Gene fusion ⁴⁸
8	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	14.32	Modifying somatic mutation ⁴⁸ GeneCards inferred via : Publications (show sections)
9	MGMT	O-6-methylguanine-DNA methyltransferase	13.45	Modifying somatic mutation ⁴⁸ GeneCards inferred via : Publications (show sections)
10	TP53	tumor protein p53	12.58	Modifying somatic mutation ⁴⁸ GeneCards inferred via : Publications (show sections)
11	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	11.30	Modifying somatic mutation ⁴⁸
12	PPARG	peroxisome proliferator-activated receptor gamma	10.43	Modifying somatic mutation ⁴⁸
13	GFAP	glial fibrillary acidic protein	9.99	GeneCards inferred via : Publications, Disorders (show sections)
14	GJA1	gap junction protein, alpha 1, 43kDa	9.12	GeneCards inferred via : Publications, Disorders (show sections)
15	CDK4	cyclin-dependent kinase 4	8.25	GeneCards inferred via : Publications, Disorders (show sections)
16	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	7.38	GeneCards inferred via : Publications, Disorders (show sections)
17	TFRC	transferrin receptor	6.51	GeneCards inferred via : Disorders (show sections)
18	TKT	transketolase	5.64	GeneCards inferred via : Disorders (show sections)
19	PTEN	phosphatase and tensin homolog	4.77	GeneCards inferred via : Publications, Disorders (show sections)
20	SNAI2	snail family zinc finger 2	3.88	GeneCards inferred via : Publications (show sections)
21	EPHB6	EPH receptor B6	3.01	GeneCards inferred via : Expressions (show sections)
22	TWIST1	twist family bHLH transcription factor 1	2.14	GeneCards inferred via : Publications (show sections)
23	IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	1.27	GeneCards inferred via : Publications (show sections)

Products for genes related to Gliosarcoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	22	-	22	22
2	Novus Biologicals	20	19	22	-

Variations for Gliosarcoma

Expression for genes affiliated with Gliosarcoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Gliosarcoma

Search GEO for disease gene expression data for Gliosarcoma.

Pathways for genes affiliated with Gliosarcoma

Sources:
⁴⁹PathCards, ⁵Cell Signaling Technology, ⁵²QIAGEN, ¹³EMD Millipore, ⁵⁰PharmGKB, ⁵⁵SinoBiological, ⁵⁹Thomson Reuters, ⁶⁰Tocris Bioscience, ³⁷NCBI BioSystems Database, ³⁰KEGG, ⁵⁴Reactome, ⁵³R&D Systems
See all sources

Pathways related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50) (show all 69)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Angiogenesis⁵	9.8	PDGFRB, FGFR1, FGFR3
2	NF-KappaB Family Pathway⁵² Show member pathways NF-KappaB (p50-p65) Pathway⁵²	9.7	NFKBIA, EGFR, FGFR1, FGFR3
3	Selected targets of p53¹³	9.7	CDK4, TP53, MGMT
4	VEGF Signaling Pathway⁵⁰ Show member pathways VEGF Signaling⁵⁵	9.7	PTEN, FGFR1, FGFR3
5	DNA damage ATM ATR regulation of G1 S checkpoint⁵⁹	9.7	CDK4, NFKBIA, TP53
6	Sorafenib Pharmacodynamics⁵⁰ Show member pathways VEGF Pathway⁶⁰ Vemurafenib Pathway, Pharmacodynamics⁵⁰	9.6	FGFR3, FGFR1, EGFR, PDGFRB
7	Tyrosine Kinases / Adaptors⁵	9.6	PDGFRB, EGFR, FGFR1, FGFR3
8	Alzheimers Disease Pathway⁵²	9.6	PDGFRB, EGFR, FGFR1, FGFR3
9	Regulation of Actin Cytoskeleton³⁷ Show member pathways Regulation of actin cytoskeleton³⁰	9.6	PDGFRB, EGFR, FGFR1, FGFR3
10	Adherens junction³⁰	9.6	FGFR1, EGFR, SNAI2
11	Aurora A signaling³⁷	9.6	TP53, NFKBIA, TACC1, TACC3
12	Cell Cycle / Checkpoint Control⁵ Show member pathways DNA Damage⁵	9.5	CDK4, TACC3, TP53, MGMT
13	Chronic myeloid leukemia³⁰ Show member pathways Pancreatic cancer³⁰	9.5	EGFR, CDK4, NFKBIA, TP53
14	4-1BB Pathway⁵² Show member pathways CD40 Signaling⁵² PKR Pathway⁵² NF-kappaB Activation by Viruses⁵² CMV and MAPK Pathways⁵² SUMO Pathway⁵² NF-KappaB Activation by EBV⁵² TNFR2 Pathway⁵² CD27 Pathway⁵²	9.5	EGFR, NFKBIA, PDGFRB, TP53
15	MAPK signaling pathway³⁰ Show member pathways MAPK signaling pathway³⁷	9.4	FGFR3, FGFR1, EGFR, PDGFRB, TP53
16	Activation of cAMP-Dependent PKA⁵² Show member pathways PKA Signaling⁵² Activation of PKA through GPCR⁵² cAMP Pathway⁵²	9.4	FGFR3, FGFR1, EGFR, NFKBIA, PDGFRB
17	Ca-dependent events⁵⁴ Show member pathways Neurophysiological process PGE2 induced pain processing⁵⁹ PLC-gamma1 signalling⁵⁴ Development Beta adrenergic receptors signaling via cAMP⁵⁹ Cam-PDE 1 activation⁵⁴ Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling⁵⁹ Opioid Signalling⁵⁴ CaM pathway⁵⁴ DAG and IP3 signaling⁵⁴ PLC beta mediated events⁵⁴ Signal transduction Calcium signaling⁵⁹ G-protein mediated events⁵⁴ PLCG1 events in ERBB2 signaling⁵⁴ Beta 2 adrenergic dependent CFTR expression⁵⁹ Phospholipase C-mediated cascade⁵⁴ CREB phosphorylation through the activation of Adenylate Cyclase⁵⁴ PKA-mediated phosphorylation of CREB⁵⁴ PKA activation in glucagon signalling⁵⁴ Development Role of Activin A in cell differentiation and proliferation⁵⁹ PKA activation⁵⁴ EGFR interacts with phospholipase C-gamma⁵⁴ Calmodulin induced events⁵⁴	9.3	PPARG, PDGFRB, EGFR, FGFR1, FGFR3
18	Neural Crest Differentiation³⁷	9.3	GFAP, SNAI2, FGFR1, FGFR3
19	HTLV-I infection³⁰	9.3	CDK4, NFKBIA, PDGFRB, TP53
20	Integrated Breast Cancer Pathway³⁷	9.3	PTEN, TP53, CDK4, EGFR
21	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	9.2	CDK4, NFKBIA, TP53, PTEN
22	Small cell lung cancer³⁰	9.2	CDK4, NFKBIA, TP53, PTEN
23	CREB Pathway⁵² Show member pathways Intracellular Calcium Signaling⁵² Activation of PKC through GPCR⁵² IP3 Pathway⁵²	9.2	PTEN, PDGFRB, EGFR, FGFR1, FGFR3
24	Spinal Cord Injury³⁷	9.1	EGFR, CDK4, GJA1, TP53, GFAP
25	Glucose / Energy Metabolism⁵	9.1	PPARG, IDH1, PTEN, TKT
26	TGF-Beta Pathway⁵² Show member pathways SOCS Pathway⁵² JAK-STAT Pathway⁵² Regulation of eIF4 and p70S6K⁵² JNK Pathway⁵² MAPK Family Pathway⁵²	9.1	TP53, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
27	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	9.1	TP53, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
28	Apoptosis Pathway⁶⁰ Show member pathways Akt Pathway⁶⁰ NF-kappaB Pathway⁶⁰	9.1	TP53, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
29	MicroRNAs in cancer³⁰	9.1	PTEN, TP53, PDGFRB, EGFR, FGFR3
30	Direct p53 effectors³⁷	9.1	EGFR, SNAI2, TP53, PTEN
31	ErbB4 Pathway⁵² Show member pathways UVC-Induced MAPK Signaling⁵² FGF Pathway⁵² LPS Stimulated MAPK Signaling⁵² Growth Hormone Signaling⁵² HMGB1 Pathway⁵² PACAP Signaling⁵² IL-4 Pathway⁵² Prolactin Signaling⁵² Thrombopoietin Pathway⁵² ErbB2-ErbB3 Heterodimers⁵² IL-2 Pathway⁵² PI3K Signaling in B-Lymphocyte⁵² TREM1 Pathway⁵² ErbB Family Pathway⁵²	9.0	PTEN, TP53, NFKBIA, EGFR, FGFR1, FGFR3
32	Development HGF signaling pathway⁵⁹ Show member pathways Development EGFR signaling via PIP3⁵⁹ Development PDGF signaling via MAPK cascades⁵⁹ Apoptosis and survival Anti apoptotic action of membrane bound ESR1⁵⁹ Signaling of Hepatocyte Growth Factor Receptor³⁷ Neurotrophin signaling pathway³⁰ Development EGFR signaling via small GTPases⁵⁹ Development Neurotrophin family signaling⁵⁹ Apoptosis and survival NGF signaling pathway⁵⁹ Apoptosis and survival Role of CDK5 in neuronal death and survival⁵⁹	9.0	PTEN, TP53, PDGFRB, NFKBIA, EGFR
33	Phospholipase-C Pathway⁵² Show member pathways PTEN Pathway⁵²	8.9	PTEN, TP53, PDGFRB, EGFR, FGFR1, FGFR3
34	Akt Signaling⁵² Show member pathways p38 Signaling⁵² Tec Kinases Signaling⁵²	8.9	PTEN, TP53, PDGFRB, EGFR, FGFR1, FGFR3
35	Downstream Signaling Events Of B Cell Receptor (BCR)⁵⁴ Show member pathways Signaling by the B Cell Receptor (BCR)⁵⁴ Activation of RAS in B Cells⁵⁴	8.9	PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
36	Class I MHC mediated antigen processing and presentation⁵⁴ Show member pathways Ubiquitin mediated proteolysis³⁰ Antigen processing- Ubiquitination and Proteasome degradation⁵⁴ Adaptive Immune System⁵⁴	8.9	PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
37	NFAT and Cardiac Hypertrophy⁵² Show member pathways Signaling Involved in Cardiac Hypertrophy⁵² IGF1R Signaling⁵²	8.9	PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
38	Signaling by FGFR⁵⁴ Show member pathways Signaling by constitutively active EGFR⁵⁴ Signaling by EGFR⁵⁴ DAP12 interactions⁵⁴ DAP12 signaling⁵⁴ Signaling by ERBB2⁵⁴ Signaling by FGFR in disease⁵⁴ Signaling by PDGF⁵⁴ Downstream signaling of activated FGFR⁵⁴ Signaling by EGFR in Cancer⁵⁴ Signalling by NGF⁵⁴ Downstream signal transduction⁵⁴ Downregulation of ERBB2-ERBB3 signaling⁵⁴ NGF signalling via TRKA from the plasma membrane⁵⁴	8.9	PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
39	Integrated Pancreatic Cancer Pathway³⁷	8.9	PTEN, TP53, NFKBIA, CDK4, EGFR, FGFR1
40	GPCR Pathway⁵² Show member pathways Breast Cancer Regulation by Stathmin1⁵² Pancreatic Adenocarcinoma⁵² P2Y Receptor Signaling⁵² Ras Pathway⁵² Paxillin Interactions⁵² NFAT in Immune Response⁵² Estrogen Pathway⁵²	8.8	TP53, PDGFRB, NFKBIA, CDK4, EGFR, FGFR1
41	Glioblastoma Multiforme⁵²	8.7	MGMT, PTEN, TP53, PDGFRB, CDK4, EGFR
42	PI-3K cascade⁵⁴ Show member pathways Downregulation of ERBB4 signaling⁵⁴ AKT phosphorylates targets in the nucleus⁵⁴ Signaling by SCF-KIT⁵⁴ PI3K events in ERBB2 signaling⁵⁴ Fc epsilon receptor (FCERI) signaling⁵⁴ PI3K events in ERBB4 signaling⁵⁴ Signaling by ERBB4⁵⁴ GAB1 signalosome⁵⁴ Negative regulation of the PI3K/AKT network⁵⁴ Role of LAT2/NTAL/LAB on calcium mobilization⁵⁴ PIP3 activates AKT signaling⁵⁴ Regulation of KIT signaling⁵⁴ AKT phosphorylates targets in the cytosol⁵⁴ AKT-mediated inactivation of FOXO1A⁵⁴ PI3K/AKT Signaling in Cancer⁵⁴ Constitutive PI3K/AKT Signaling in Cancer⁵⁴ PI3K/AKT activation⁵⁴	8.6	GFAP, PTEN, PDGFRB, NFKBIA, EGFR, FGFR1
43	PI3K-Akt signaling pathway³⁰	8.6	PTEN, TP53, PDGFRB, CDK4, EGFR, FGFR1
44	Akt Signaling Pathway⁵³	8.6	FGFR3, PTEN, TP53, PDGFRB, CDK4, EGFR
45	Apoptotic Pathways in Synovial Fibroblasts⁵² Show member pathways Actin-Based Motility by Rho Family GTPases⁵² PPAR Pathway⁵² Cellular Apoptosis Pathway⁵² Rac1 Pathway⁵² Glioma Invasiveness⁵² eIF2 Pathway⁵² ERK5 Signaling⁵² p53 Mediated Apoptosis⁵² Mitochondrial Apoptosis⁵² Rap1 Pathway⁵² Telomerase Components in Cell Signaling⁵² Nuclear Receptor Activation by Vitamin-A⁵² DHA Signaling⁵²	8.4	PPARG, PTEN, TP53, PDGFRB, NFKBIA, EGFR
46	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	8.4	PTEN, SNAI2, PDGFRB, NFKBIA, EGFR, FGFR1
47	Signaling by GPCR⁵⁴ Show member pathways GPCR downstream signaling⁵⁴ Signal Transduction⁵⁴	8.4	GFAP, PTEN, TP53, PDGFRB, NFKBIA, EGFR
48	Glioma³⁰ Show member pathways Melanoma³⁰ Non-small cell lung cancer³⁰ Bladder cancer³⁰ Prostate cancer³⁰ Signaling Pathways in Glioblastoma³⁷	8.3	PTEN, TP53, PDGFRB, NFKBIA, CDK4, EGFR
49	Pathways in cancer³⁰	8.1	PPARG, PTEN, TP53, PDGFRB, NFKBIA, CDK4
50	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	7.5	GFAP, PTEN, TP53, SNAI2, PDGFRB, NFKBIA

Compounds for genes affiliated with Gliosarcoma

Sources:
⁴⁴Novoseek, ⁵⁰PharmGKB, ¹²DrugBank, ⁶⁰Tocris Bioscience, ²⁵HMDB, ²⁹IUPHAR, ³BitterDB
See all sources

Compounds related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50) (show all 170)

id	Compound	Score	Top Affiliating Genes
1	bcnu⁴⁴	9.8	MGMT, GFAP, EGFR, TP53
2	suberoylanilide hydroxamic acid⁴⁴	9.7	TP53, PPARG, NFKBIA, EGFR, FGFR1
3	bortezomib⁴⁴ ⁵⁰ ¹²	11.5	NFKBIA, FGFR3, EGFR, TP53, PTEN
4	topotecan⁴⁴ ¹²	10.5	MGMT, EGFR, PDGFRB, TKT, TP53
5	curcumin⁴⁴	9.3	EGFR, CDK4, NFKBIA, MGMT, PPARG, TP53
6	egcg⁴⁴	9.3	EGFR, CDK4, NFKBIA, PDGFRB, TP53, MGMT
7	gemcitabine⁴⁴ ⁵⁰ ¹²	11.3	PDGFRB, NFKBIA, TP53, PTEN, EGFR
8	thymidylate⁴⁴	9.2	TKT, EGFR, CDK4, TP53, MGMT, NFKBIA
9	retinoid⁴⁴	9.2	EGFR, CDK4, NFKBIA, PPARG, TP53, GJA1
10	cetuximab⁴⁴ ⁵⁰ ¹²	11.2	PTEN, PDGFRB, TKT, EGFR
11	sb 203580⁴⁴ ⁶⁰	10.1	CDK4, TP53, FGFR1, PPARG, GJA1, NFKBIA
12	imatinib⁴⁴ ⁵⁰ ¹²	11.1	FGFR3, FGFR1, EGFR, PDGFRB, PTEN, TKT
13	gefitinib⁴⁴ ⁵⁰ ¹²	11.1	TKT, PTEN, EGFR, PDGFRB, CDK4
14	n acetylcysteine⁴⁴	9.0	TFRC, NFKBIA, CDK4, EGFR, TP53, PPARG
15	12-o-tetradecanoylphorbol 13-acetate⁴⁴	8.9	CDK4, MGMT, FGFR1, TKT, GJA1, NFKBIA
16	gf 109203x⁴⁴ ⁶⁰	9.9	TKT, PPARG, TFRC, NFKBIA, EGFR
17	pd 98,059⁴⁴	8.9	PTEN, FGFR1, GFAP, GJA1, NFKBIA, CDK4
18	etoposide⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.8	TKT, GJA1, NFKBIA, TP53, PTEN, MGMT
19	bromodeoxyuridine⁴⁴	8.8	FGFR1, GJA1, NFKBIA, PDGFRB, GFAP, TKT
20	calcitriol⁴⁴ ⁶⁰ ²⁵ ¹²	11.8	CDK4, NFKBIA, PDGFRB, GJA1, PTEN, TFRC
21	methionine⁴⁴	8.7	PDGFRB, GFAP, MGMT, PTEN, FGFR1, GJA1
22	oligonucleotide⁴⁴	8.6	PDGFRB, TP53, FGFR3, FGFR1, CDK4, NFKBIA
23	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	11.6	NFKBIA, TFRC, MGMT, PPARG, GFAP, FGFR3
24	phosphotyrosine⁴⁴	8.5	EGFR, FGFR3, PTEN, FGFR1, TKT, CDK4
25	thymidine⁴⁴ ²⁵	9.5	FGFR1, TKT, CDK4, GJA1, TFRC, GFAP
26	glutamate⁴⁴	8.5	GJA1, FGFR3, TKT, TFRC, IDH1, GFAP
27	5fluorouracil⁴⁴	8.5	EGFR, PTEN, TP53, MGMT, NFKBIA, CDK4
28	agar⁴⁴	8.4	PTEN, CDK4, EGFR, PDGFRB, GFAP, GJA1
29	doxorubicin⁴⁴ ⁵⁰ ¹²	10.4	NFKBIA, MGMT, FGFR3, TFRC, CDK4, GJA1
30	phosphatidylinositol⁴⁴	8.4	TFRC, EGFR, FGFR1, NFKBIA, CDK4, GJA1
31	h2o2⁴⁴	8.3	GJA1, PDGFRB, TP53, PTEN, TFRC, NFKBIA
32	rapamycin⁴⁴	8.3	PTEN, EGFR, PDGFRB, NFKBIA, CDK4, TKT
33	glucose⁴⁴	8.2	PTEN, CDK4, FGFR1, GFAP, GJA1, MGMT
34	vitamin d⁴⁴	8.2	NFKBIA, TFRC, PTEN, PPARG, CDK4, PDGFRB
35	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	12.1	NFKBIA, PTEN, MGMT, GFAP, TP53, PDGFRB
36	alanine⁴⁴	8.0	NFKBIA, TFRC, PPARG, PTEN, CDK4, GFAP
37	ly294002⁴⁴	8.0	CDK4, NFKBIA, GJA1, TP53, PTEN, TFRC
38	cysteine⁴⁴	8.0	GFAP, PTEN, PDGFRB, FGFR3, FGFR1, CDK4
39	cycloheximide⁴⁴	7.8	PPARG, TP53, PTEN, GFAP, GJA1, NFKBIA
40	paclitaxel⁴⁴ ⁵⁰ ¹²	9.8	MGMT, TFRC, FGFR1, EGFR, CDK4, PDGFRB
41	paraffin⁴⁴	7.6	TFRC, GFAP, PTEN, TP53, PDGFRB, GJA1
42	calcium⁴⁴ ⁵⁰ ²⁵ ¹²	10.6	GFAP, PTEN, PDGFRB, GJA1, NFKBIA, CDK4
43	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	10.5	CDK4, TKT, NFKBIA, GJA1, PDGFRB, PTEN
44	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	10.5	MGMT, TFRC, PTEN, TP53, PDGFRB, GJA1
45	genistein⁴⁴ ²⁹ ⁶⁰ ³ ²⁵ ¹²	12.3	GFAP, TFRC, MGMT, FGFR1, EGFR, PTEN
46	serine⁴⁴	7.2	CDK4, GJA1, TFRC, GFAP, PTEN, TP53
47	retinoic acid⁴⁴ ²⁵	8.1	FGFR1, EGFR, TKT, CDK4, NFKBIA, GJA1
48	tyrosine⁴⁴	7.1	CDK4, PDGFRB, NFKBIA, TFRC, PTEN, FGFR3
49	vegf⁴⁴	6.9	FGFR3, PPARG, MGMT, FGFR1, EGFR, TKT
50	estrogen⁴⁴	6.6	CDK4, PPARG, NFKBIA, GJA1, PDGFRB, SNAI2

GO Terms for genes affiliated with Gliosarcoma

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Gliosarcoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasmic membrane-bounded vesicle	GO:016023	9.3	TFRC, PDGFRB, FGFR1, FGFR3
2	cytoplasm	GO:005737	7.6	GFAP, PTEN, TP53, SNAI2, PDGFRB, NFKBIA
3	cytosol	GO:005829	7.5	PPARG, IDH1, GFAP, PTEN, TP53, NFKBIA
4	nucleus	GO:005634	6.7	FGFR3, PPARG, MGMT, PTEN, TP53, SNAI2

Biological processes related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	GO:090080	10.5	FGFR1, FGFR3
2	positive regulation of phospholipase activity	GO:010518	10.5	FGFR1, FGFR3
3	interkinetic nuclear migration	GO:022027	10.4	TACC1, TACC3
4	MAPK cascade	GO:000165	10.3	FGFR3, FGFR1, EGFR
5	regulation of microtubule-based process	GO:032886	10.3	TACC1, TACC3
6	positive regulation of phospholipase C activity	GO:010863	10.3	PDGFRB, FGFR1
7	digestive tract morphogenesis	GO:048546	10.3	FGFR3, EGFR
8	cytoplasmic sequestering of transcription factor	GO:042994	10.3	NFKBIA, TACC3
9	regulation of peptidyl-tyrosine phosphorylation	GO:050730	10.2	EGFR, PDGFRB
10	response to fluid shear stress	GO:034405	10.2	PDGFRB, GJA1
11	positive regulation of MAP kinase activity	GO:043406	10.2	FGFR1, EGFR, PDGFRB
12	negative regulation of macrophage derived foam cell differentiation	GO:010745	10.1	PPARG, NFKBIA
13	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.1	PDGFRB, EGFR, FGFR3
14	response to hyperoxia	GO:055093	10.0	CDK4, PDGFRB
15	cell division	GO:051301	10.0	CDK4, TACC1, SEPT14
16	peptidyl-tyrosine phosphorylation	GO:018108	10.0	PDGFRB, EGFR, FGFR1, FGFR3
17	protein autophosphorylation	GO:046777	10.0	PDGFRB, EGFR, FGFR1, FGFR3
18	white fat cell differentiation	GO:050872	10.0	SNAI2, PPARG
19	regulation of tight junction assembly	GO:2000810	10.0	GJA1, SNAI2
20	response to toxic substance	GO:009636	9.9	CDK4, PDGFRB, MGMT
21	cellular response to ionizing radiation	GO:071479	9.9	SNAI2, TP53, MGMT
22	cellular response to epidermal growth factor stimulus	GO:071364	9.8	EGFR, SNAI2
23	long-term synaptic potentiation	GO:060291	9.7	PTEN, GFAP
24	positive regulation of vasoconstriction	GO:045907	9.7	EGFR, GJA1
25	cell migration	GO:016477	9.6	PTEN, PDGFRB, FGFR1
26	phosphatidylinositol-mediated signaling	GO:048015	9.6	PTEN, PDGFRB, EGFR, FGFR1, FGFR3
27	fibroblast growth factor receptor signaling pathway	GO:008543	9.6	PTEN, PDGFRB, EGFR, FGFR1, FGFR3
28	epidermal growth factor receptor signaling pathway	GO:007173	9.6	PTEN, PDGFRB, EGFR, FGFR1, FGFR3
29	positive regulation of cell migration	GO:030335	9.5	EGFR, PDGFRB, SNAI2
30	response to drug	GO:042493	9.5	PPARG, MGMT, PTEN, CDK4
31	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.4	PPARG, TP53, SNAI2, FGFR1, FGFR3
32	negative regulation of apoptotic process	GO:043066	9.4	PTEN, TP53, PDGFRB, NFKBIA, EGFR
33	heart development	GO:007507	9.4	PPARG, PTEN, GJA1
34	Fc-epsilon receptor signaling pathway	GO:038095	9.3	FGFR3, FGFR1, EGFR, NFKBIA, PDGFRB, PTEN
35	neurotrophin TRK receptor signaling pathway	GO:048011	9.3	PTEN, PDGFRB, NFKBIA, EGFR, FGFR1, FGFR3
36	positive regulation of cell proliferation	GO:008284	9.2	PTEN, PDGFRB, CDK4, EGFR, FGFR1, FGFR3
37	innate immune response	GO:045087	9.0	PPARG, PTEN, PDGFRB, NFKBIA, EGFR, FGFR1

Molecular functions related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	fibroblast growth factor-activated receptor activity	GO:005007	10.2	FGFR3, FGFR1
2	fibroblast growth factor binding	GO:017134	10.1	FGFR3, FGFR1
3	protein tyrosine kinase activity	GO:004713	9.8	FGFR3, FGFR1, EGFR, PDGFRB
4	platelet-derived growth factor receptor binding	GO:005161	9.6	PDGFRB, PTEN
5	identical protein binding	GO:042802	9.4	TFRC, TP53, NFKBIA, EGFR, FGFR1
6	protein kinase binding	GO:019901	9.3	PTEN, TP53, PDGFRB, EGFR
7	enzyme binding	GO:019899	9.3	PPARG, PTEN, TP53, NFKBIA, EGFR
8	chromatin binding	GO:003682	9.3	PPARG, TP53, SNAI2, EGFR
9	ATP binding	GO:005524	8.7	TP53, PDGFRB, CDK4, EGFR, FGFR1, FGFR3
10	protein binding	GO:005515	7.0	FGFR3, PPARG, TFRC, PTEN, TP53, SEPT14