MCID: GLS001
MIFTS: 60

Gliosarcoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Gliosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain... more...

MalaCards: Gliosarcoma, also known as glioblastoma with a sarcomatous component, is related to glioblastoma multiforme and sarcoma. An important gene associated with Gliosarcoma is SEPT14 (septin 14), and among its related pathways are TGF-Beta Pathway and NF-KappaB Family Pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are embryogenesis and hearing/vestibular/ear.

Aliases & Classifications for Gliosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
gliosarcoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

gliosarcoma 8 42 10 44 48 60
glioblastoma with a sarcomatous component 8
glioblastoma with sarcomatous component 8
sarcomatous glioblastoma 42


External Ids:

Disease Ontology8 DOID:3071
MeSH34 D018316
NCIt39 C3796
SNOMED-CT via Orphanet57 35262004

Related Diseases for Gliosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Gliosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1glioblastoma multiforme30.5CDK4, GJA1, PDGFRB, MGMT, EGFR, TP53
2sarcoma30.3TP53, PDGFRB, CDK4
3herpes simplex30.2GJA1
4astrocytoma30.1IDH1, PDGFRB, MGMT, EGFR, CDK4, GJA1
5meningioma30.0PDGFRB, PTEN, GFAP
6osteosarcoma30.0PDGFRB, TP53, GJA1, CDK4
7medulloblastoma30.0CDK4, GFAP, MGMT, TP53
8rhabdomyosarcoma29.8CDK4, GJA1, PDGFRB, TP53
9giant cell glioblastoma29.8GFAP, EGFR, PTEN
10oligodendroglioma29.8GFAP, MGMT, EGFR, PTEN
11pancreatic cancer29.8PDGFRB, MGMT, EGFR, NFKBIA
12chondrosarcoma29.8FGFR1, CDK4, NFKBIA, PDGFRB, FGFR3
13squamous cell carcinoma29.8FGFR3, MGMT, EGFR, NFKBIA, GJA1, PTEN
14melanoma29.8GJA1, PTEN, FGFR3, FGFR1, EPHB6, CDK4
15cerebritis10.5
16adult brainstem gliosarcoma10.2
17neurofibromatosis10.1
18meningitis10.1
19adenoid cystic carcinoma10.0
20adenoiditis10.0
21leiomyoma10.0GJA1
22gastrointestinal stromal tumor10.0PDGFRB
23paraganglioma10.0GFAP
24fibrosarcoma10.0PDGFRB
25seminoma10.0GJA1
26gliomatosis cerebri10.0GFAP, PTEN
27myelofibrosis10.0PDGFRB
28gemistocytic astrocytoma10.0PTEN, GFAP
29hepatitis10.0TFRC
30myeloid leukemia10.0TFRC, CDK4
31chordoma10.0PDGFRB, GFAP
32anaplastic ependymoma10.0GFAP, PTEN
33hemangioblastoma10.0GFAP
34salivary gland cancer10.0PPARG
35peutz-jeghers syndrome10.0PTEN
36amyotrophic lateral sclerosis10.0GFAP, TFRC
37neurofibroma10.0PDGFRB
38pituitary tumors10.0PPARG
39gallbladder cancer10.0TP53
40oligoastrocytoma10.0GFAP, MGMT
41tuberous sclerosis10.0PDGFRB, GFAP, PTEN
42choriocarcinoma10.0PPARG
43neuroblastoma10.0TP53, EPHB6
44lipoma10.0CDK4, PTEN
45malignant mesothelioma10.0CDK4, PDGFRB
46cholangiocarcinoma10.0TP53
47pulmonary fibrosis10.0PDGFRB, PPARG
48li-fraumeni syndrome10.0PTEN, TP53
49nelson syndrome10.0PPARG
50pituitary adenoma10.0PPARG, MGMT, CDK4

Graphical network of the top 20 diseases related to Gliosarcoma:



Diseases related to gliosarcoma

Clinical Features for Gliosarcoma

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Drugs & Therapeutics for Gliosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gliosarcoma

Drug clinical trials:

Search ClinicalTrials for Gliosarcoma

Search NIH Clinical Center for Gliosarcoma

Search CenterWatch for Gliosarcoma

Genetic Tests for Gliosarcoma

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Anatomical Context for Gliosarcoma

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32MalaCards
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MalaCards organs/tissues related to Gliosarcoma:

32
Brain, Spinal cord, Bone, Smooth muscle, Lung, Nk cells, T cells, Thalamus, Pineal

Animal Models for Gliosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gliosarcoma:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.4PPARG, TACC3, GJA1
2MP:000537710.3GJA1, FGFR3
3MP:000539010.3GJA1, FGFR3, FGFR1, EPHB6
4MP:000539110.2PPARG, EGFR, FGFR3, GJA1, GFAP
5MP:000536710.2PPARG, EGFR, EPHB6, FGFR1, FGFR3
6MP:000537910.2PDGFRB, MGMT, CDK4, FGFR1, TP53
7MP:001077110.0NFKBIA, CDK4, EPHB6, FGFR1, GJA1, PTEN
8MP:000536910.0PDGFRB, CDK4, FGFR1, GJA1, GFAP, TP53
9MP:00036319.9PPARG, TFRC, CDK4, GJA1, GFAP
10MP:00053899.9EGFR, EPHB6, FGFR3, PTEN, TP53
11MP:00053829.8LZTR1, PDGFRB, EGFR, FGFR1, FGFR3, TACC3
12MP:00020069.8PPARG, MGMT, EGFR, CDK4, EPHB6, FGFR3
13MP:00030129.7PPARG, MGMT, EGFR, EPHB6, FGFR1, FGFR3
14MP:00053819.6PDGFRB, TFRC, EGFR, CDK4, EPHB6, FGFR1
15MP:00053769.6IDH1, LZTR1, PDGFRB, MGMT, TFRC, NFKBIA
16MP:00028739.5PDGFRB, PPARG, EGFR, NFKBIA, EPHB6, FGFR1
17MP:00053859.5PDGFRB, PPARG, TFRC, EGFR, CDK4, FGFR1
18MP:00053709.4PPARG, TFRC, EGFR, CDK4, TACC3, PTEN
19MP:00053979.3EGFR, TFRC, PPARG, PDGFRB, IDH1, NFKBIA
20MP:00053869.3PPARG, CDK4, EPHB6, FGFR1, FGFR3, TACC3
21MP:00053849.2CDK4, NFKBIA, EGFR, TFRC, PPARG, PDGFRB
22MP:00053789.2CDK4, NFKBIA, EGFR, TFRC, PPARG, PDGFRB
23MP:00053879.2TP53, IDH1, PDGFRB, PPARG, TFRC, EGFR
24MP:00107689.2EGFR, TFRC, MGMT, PPARG, PDGFRB, LZTR1

Publications for Gliosarcoma

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50PubMed
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Articles related to Gliosarcoma:

(show top 50)    (show all 298)
idTitleAuthorsYear
1
Genetic and pathologic evolution of early secondary gliosarcoma. (23324827)
2014
2
Temozolomide use in adult patients with gliosarcoma: an evolving clinical practice. (23266723)
2013
3
Primary intraventricular gliosarcoma. (23557905)
2013
4
Gliosarcoma with ependymal and PNET-like differentiation. (23863343)
2013
5
Secondary gliosarcoma with extra-cranial metastases: a report and review of the literature. (22795300)
2013
6
A case study of a patient with gliosarcoma with an extended survival and spinal cord metastases. (22198898)
2012
7
Transcriptional factors for epithelial-mesenchymal transition are associated with mesenchymal differentiation in gliosarcoma. (22288519)
2012
8
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. (21896554)
2011
9
Intraventricular gliosarcoma: unusual location of an uncommon tumor. (19575149)
2010
10
Secondary gliosarcoma: a review of clinical features and pathological diagnosis. (19408981)
2010
11
Transformation of intracranial anaplastic astrocytoma associated with neurofibromatosis type I into gliosarcoma: case report. (20466481)
2010
12
Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo. (19937755)
2010
13
Cytopatholologic features of gliosarcoma with areas of primitive neuroepithelial differentiation of the brain in squash smears. (19582814)
2009
14
Multiple spinal metastases of cranial gliosarcoma: a case report and review of the literature. (18317692)
2008
15
Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts. (17924591)
2008
16
Gliosarcoma with primitive neuroectodermal differentiation: case report and review of the literature. (17406789)
2007
17
Assessment of the morphological and functional effects of the anti-angiogenic agent SU11657 on 9L gliosarcoma vasculature using dynamic susceptibility contrast MRI. (17390352)
2007
18
Gliosarcoma with liposarcomatous differentiation: the new member of the lipid-containing brain tumors family. (16519569)
2006
19
9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A. (16352703)
2006
20
Gliosarcoma with features of osteoblastic osteosarcoma: a review. (16879025)
2006
21
Multi-focal gliosarcoma: a case report and review of the literature. (16086111)
2005
22
Gliosarcoma arising from an anaplastic ependymoma: a case report of a rare entity. (15116335)
2004
23
Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRI cerebral blood volume maps. (14565159)
2003
24
Pathologic quiz case: cerebellar hemorrhage in an octogenarian. Gliosarcoma. (12873200)
2003
25
Expression of a soluble transforming growth factor-beta (TGFbeta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo. (12952287)
2003
26
Effects of IFN-gamma and interleukin-1beta on major histocompatibility complex antigen and intercellular adhesion molecule-1 expression by 9L gliosarcoma: relevance to its cytolysis by alloreactive cytotoxic T lymphocytes. (12581494)
2002
27
Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy. (12061726)
2002
28
Granulocyte macrophage-colony stimulating factor gene transfer to induce a protective anti-tumoral immune response against the 9L rat gliosarcoma model. (11956607)
2002
29
Evaluation and optimization of DNA delivery into gliosarcoma 9L cells by a cholesterol-based cationic liposome. (12175922)
2002
30
Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components. (12112531)
2002
31
Gliosarcoma associated with neurofibromatosis type I: a case report. (11669561)
2001
32
HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma. (11001368)
2000
33
Early effects of PRS-irradiation for 9L gliosarcoma: characterization of interphase cell death. (11270831)
2000
34
A clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants. (9378529)
1997
35
Regional differences in apoptosis in murine gliosarcoma (T9) induced by mild hyperthermia. (9044904)
1996
36
Radiation-associated gliosarcoma. (8640419)
1996
37
Hyperthermic enhancement of high dose-rate irradiation in 9L gliosarcoma cells. (8270439)
1994
38
Neutron capture therapy of the 9L rat gliosarcoma using the p-boronophenylalanine-fructose complex. (7928496)
1994
39
Interphase cytogenetics of glioblastoma and gliosarcoma. (7847070)
1994
40
Distribution of p53 protein expression in gliosarcomas: an immunohistochemical study. (8382897)
1993
41
Interstitial chemotherapy of the 9L gliosarcoma: controlled release polymers for drug delivery in the brain. (8417826)
1993
42
Histogenesis of sarcomatous component of the gliosarcoma: an ultrastructural study. (2082657)
1990
43
The effects of irradiation on major histocompatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model. (2332484)
1990
44
Gliosarcoma: an immunohistochemical study. (2609937)
1989
45
In vivo 31P nuclear magnetic resonance spectroscopy of rat 9L gliosarcoma treated with BCNU: dose response of spectral changes. (2779416)
1989
46
Biological and karyotypic characterization of a new cell line derived from human gliosarcoma. (3275500)
1988
47
Gliosarcoma developing in close relationship to an abscess cavity injected with thorotrast. (3336841)
1988
48
Cytotoxic effect and induction of sister chromatid exchange in exponentially growing rat 9L gliosarcoma cells after brief exposure to BrdU. (3690627)
1987
49
Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor. (6788362)
1981
50
Association of a phaeochromocytoma and cerebral gliosarcoma with neurofibromatosis. (4289271)
1967

Genetic Variations for Gliosarcoma

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Expression for genes affiliated with Gliosarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gliosarcoma

Search GEO for disease gene expression data for Gliosarcoma.

Pathways for genes affiliated with Gliosarcoma

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Sources:
51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 59Tocris Bioscience, 53Reactome, 52R&D Systems
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Pathways related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3EPHB6
2
Hide members
10.2FGFR3, FGFR1, NFKBIA
310.2FGFR3, FGFR1, PDGFRB
410.2FGFR3, FGFR1, EPHB6
510.1MGMT, CDK4, TP53
610.1TP53, CDK4, NFKBIA
7
Hide members
10.1FGFR3, EPHB6, PDGFRB
8
Hide members
10.1TP53, PTEN, NFKBIA
910.1TFRC, CDK4, TP53
10
Hide members
10.1TP53, PTEN, CDK4
1110.1TP53, TACC3, TACC1, NFKBIA
1210.1PDGFRB, EGFR, FGFR1, FGFR3
13
Hide members
10.1FGFR3, FGFR1, EGFR, PDGFRB
14
Hide members
10.1PDGFRB, EGFR, FGFR1, FGFR3
15
Hide members
10.0EGFR, NFKBIA, CDK4, TP53
1610.0EGFR, CDK4, PTEN, TP53
1710.0PDGFRB, NFKBIA, CDK4, TP53
18
Hide members
10.0NFKBIA, CDK4, PTEN, TP53
1910.0NFKBIA, CDK4, PTEN, TP53
20
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10.0TP53, FGFR3, FGFR1, EGFR, PDGFRB
21
Hide members
9.9PDGFRB, NFKBIA, FGFR1, FGFR3, TP53
22
Hide members
9.9PDGFRB, EGFR, EPHB6, FGFR1, FGFR3
23
Hide members
9.9PDGFRB, EGFR, EPHB6, FGFR1, FGFR3
249.9PDGFRB, EGFR, FGFR3, PTEN, TP53
259.9EGFR, CDK4, GJA1, GFAP, TP53
26
Hide members
9.9PDGFRB, EGFR, NFKBIA, PTEN, TP53
27
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9.9PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, TP53
28
Hide members
9.8PDGFRB, EGFR, FGFR1, FGFR3, PTEN, TP53
29
Hide members
9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
30
Hide members
9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
31
Hide members
9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
32
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
33
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
34
Hide members
9.8PDGFRB, EGFR, FGFR1, FGFR3, GFAP, PTEN
35
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9.8PDGFRB, EGFR, NFKBIA, EPHB6, FGFR1, FGFR3
36
Hide members
9.8NFKBIA, CDK4, EPHB6, FGFR1, FGFR3, TP53
379.8EGFR, NFKBIA, CDK4, FGFR1, PTEN, TP53
389.8PDGFRB, MGMT, EGFR, CDK4, PTEN, TP53
39
Hide members
9.7PDGFRB, EGFR, NFKBIA, EPHB6, FGFR1, FGFR3
409.7TP53, PDGFRB, EGFR, CDK4, FGFR1, FGFR3
419.7PDGFRB, EGFR, CDK4, FGFR1, FGFR3, PTEN
42
Hide members
9.7PDGFRB, EGFR, EPHB6, FGFR1, FGFR3, PTEN
43
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9.6PDGFRB, PPARG, EGFR, NFKBIA, FGFR1, FGFR3
449.5PDGFRB, PPARG, EGFR, NFKBIA, CDK4, FGFR1
45
Hide members
9.3PDGFRB, EGFR, NFKBIA, CDK4, EPHB6, FGFR1

Compounds for genes affiliated with Gliosarcoma

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8GFAP
2cycloheximide4410.6GJA1, TFRC
3bcnu4410.4MGMT, GFAP, EGFR, TP53
4serine4410.4NFKBIA, FGFR3, TACC3, GJA1, GFAP
5suberoylanilide hydroxamic acid4410.4PPARG, TP53, FGFR1, EGFR, NFKBIA
6bortezomib44 1111.3TP53, PTEN, FGFR3, NFKBIA, EGFR
7topotecan44 1111.3PDGFRB, MGMT, EGFR, TP53
8thymidylate4410.3MGMT, CDK4, NFKBIA, EGFR, TP53
9gemcitabine44 49 1112.3TP53, PDGFRB, PTEN, NFKBIA, EGFR
10pge24410.2PTEN, EGFR
11dexamethasone44 49 28 1113.2MGMT, GJA1, CDK4, NFKBIA, GFAP
12su54164410.2PDGFRB, FGFR1, EGFR
13curcumin4410.2MGMT, TP53, CDK4, NFKBIA, EGFR, PPARG
14h2o24410.2FGFR1, PTEN, NFKBIA, PDGFRB
15flavopiridol44 1111.2CDK4, PDGFRB, TP53, EGFR
16bromodeoxyuridine4410.2NFKBIA, CDK4, FGFR1, PDGFRB, GJA1, GFAP
17imatinib44 49 1112.2PDGFRB, PTEN, FGFR3, EGFR, FGFR1
18retinoid4410.1PPARG, CDK4, TP53, EGFR, NFKBIA, GJA1
19doxycycline44 1111.1NFKBIA, GJA1, TFRC, GFAP
20sb 20358044 5911.1TP53, GJA1, PPARG, EGFR, NFKBIA, CDK4
21gw966244 2811.1GJA1, PPARG, PTEN
22ly2940024410.1NFKBIA, GJA1, TFRC, CDK4, PDGFRB, PPARG
23phosphotyrosine4410.1FGFR3, FGFR1, CDK4, EGFR, PDGFRB, GJA1
24n acetylcysteine4410.1TP53, CDK4, NFKBIA, EGFR, TFRC, PPARG
25calcitriol44 59 11 2413.1TFRC, NFKBIA, CDK4, PDGFRB, PTEN, GJA1
265fluorouracil4410.1MGMT, NFKBIA, PTEN, TP53, CDK4, EGFR
27agar4410.1PTEN, FGFR1, CDK4, PDGFRB, EGFR, GFAP
28pd 98,0594410.1FGFR1, PTEN, EGFR, NFKBIA, CDK4, GJA1
29methionine4410.1PTEN, GFAP, MGMT, PDGFRB, GJA1, FGFR1
30rapamycin4410.0EGFR, PPARG, TFRC, PDGFRB, NFKBIA, CDK4
31glucose4410.0NFKBIA, FGFR1, GFAP, PTEN, MGMT, PPARG
32vitamin d4410.0NFKBIA, CDK4, PDGFRB, PPARG, TFRC, PTEN
33thymidine44 2411.0GJA1, GFAP, TP53, TFRC, CDK4, MGMT
34paclitaxel44 49 1112.0TP53, PTEN, PDGFRB, EGFR, NFKBIA, CDK4
35carboplatin44 49 1111.9MGMT, CDK4, EGFR, TP53
36oligonucleotide449.9CDK4, TP53, PDGFRB, NFKBIA, MGMT, FGFR1
37proline449.9TP53, GJA1, NFKBIA, PDGFRB, MGMT, CDK4
38doxorubicin44 49 1111.9PTEN, MGMT, TFRC, EGFR, NFKBIA, CDK4
39phosphatidylinositol449.8PTEN, GJA1, NFKBIA, FGFR1, CDK4, EGFR
40progesterone44 59 28 11 2413.8MGMT, FGFR1, GFAP, TP53, PTEN, GJA1
41paraffin449.8EGFR, FGFR3, GJA1, PDGFRB, MGMT, TP53
42alanine449.8PTEN, NFKBIA, CDK4, GJA1, PDGFRB, PPARG
43testosterone44 59 11 2412.7PDGFRB, NFKBIA, CDK4, FGFR1, EGFR, GJA1
44cisplatin44 49 59 1112.7PTEN, TFRC, NFKBIA, GFAP, GJA1, CDK4
45cysteine449.7FGFR3, TFRC, MGMT, PDGFRB, NFKBIA, CDK4
46gefitinib44 49 1111.7EGFR, PDGFRB, PTEN, CDK4
47genistein44 28 59 2 11 2414.7PTEN, NFKBIA, GFAP, GJA1, FGFR1, CDK4
48tyrosine449.6PTEN, GFAP, GJA1, EGFR, FGFR1, NFKBIA
49retinoic acid44 2410.5GJA1, NFKBIA, PTEN, TP53, PDGFRB, EGFR
50vegf449.5GFAP, GJA1, FGFR3, FGFR1, CDK4, NFKBIA

GO Terms for genes affiliated with Gliosarcoma

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Sources:
16Gene Ontology
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Cellular components related to Gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.7FGFR3, FGFR1, TFRC, PDGFRB
2cytosolGO:0058299.5PPARG, NFKBIA, CDK4, FGFR1, GJA1, GFAP

Biological processes related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:01051810.6FGFR3, FGFR1
2positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.6FGFR3, FGFR1
3interkinetic nuclear migrationGO:02202710.5TACC3, TACC1
4positive regulation of phospholipase C activityGO:01086310.5FGFR1, PDGFRB
5positive regulation of MAP kinase activityGO:04340610.5FGFR1, EGFR, PDGFRB
6peptidyl-tyrosine phosphorylationGO:01810810.5PDGFRB, FGFR1, FGFR3
7MAPK cascadeGO:00016510.4EGFR, FGFR1, FGFR3
8protein autophosphorylationGO:04677710.4PDGFRB, EGFR, FGFR1, FGFR3
9regulation of peptidyl-tyrosine phosphorylationGO:05073010.4EGFR, PDGFRB
10phosphatidylinositol-mediated signalingGO:04801510.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
11fibroblast growth factor receptor signaling pathwayGO:00854310.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
12response to toxic substanceGO:00963610.3PDGFRB, MGMT, CDK4
13epidermal growth factor receptor signaling pathwayGO:00717310.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
14in utero embryonic developmentGO:00170110.3PDGFRB, FGFR1, GJA1, TP53
15negative regulation of macrophage derived foam cell differentiationGO:01074510.3NFKBIA, PPARG
16positive regulation of ERK1 and ERK2 cascadeGO:07037410.2PDGFRB, EGFR, FGFR3
17response to hyperoxiaGO:05509310.2CDK4, PDGFRB
18regulation of microtubule-based processGO:03288610.2TACC3, TACC1
19Fc-epsilon receptor signaling pathwayGO:03809510.2PTEN, FGFR3, FGFR1, NFKBIA, EGFR, PDGFRB
20neurotrophin TRK receptor signaling pathwayGO:04801110.2PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
21negative regulation of apoptotic processGO:04306610.2EGFR, NFKBIA, FGFR1, FGFR3, PTEN, TP53
22positive regulation of cell proliferationGO:00828410.1PDGFRB, EGFR, CDK4, FGFR1, FGFR3, PTEN
23innate immune responseGO:04508710.1PDGFRB, PPARG, EGFR, NFKBIA, FGFR1, FGFR3
24cytoplasmic sequestering of transcription factorGO:04299410.0TACC3, NFKBIA

Molecular functions related to Gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00500710.2FGFR3, FGFR1
2protein tyrosine kinase activityGO:00471310.2FGFR3, FGFR1, EGFR, PDGFRB
3enzyme bindingGO:01989910.0PPARG, EGFR, NFKBIA, PTEN, TP53
4ATP bindingGO:0055249.7TP53, FGFR3, FGFR1, EPHB6, CDK4, EGFR
5identical protein bindingGO:0428029.6TFRC, EGFR, NFKBIA, FGFR1, TP53
6protein bindingGO:0055159.0PDGFRB, PPARG, TFRC, EGFR, NFKBIA, CDK4

Products for genes affiliated with Gliosarcoma

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Sources for Gliosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet