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Gliosarcoma malady

Neuronal diseases, Cancer diseases categories
46 genes, 9 tissues, 143 related diseases, clinical trials.

Summaries for Gliosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain... more...

MalaCards: Gliosarcoma, also known as glioblastoma with a sarcomatous component, is related to glioblastoma multiforme and sarcoma. An important gene associated with Gliosarcoma is SEPT14 (septin 14), and among its related pathways are TGF-Beta Pathway and NF-KappaB Family Pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are embryogenesis and hearing/vestibular/ear.

Aliases & Classifications for Gliosarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
gliosarcoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

gliosarcoma 8 42 10 44 48 60
glioblastoma with a sarcomatous component 8
glioblastoma with sarcomatous component 8
sarcomatous glioblastoma 42


External Ids:

Disease Ontology8 DOID:3071
MeSH34 D018316
NCIt39 C3796
SNOMED-CT via Orphanet57 35262004

Related Diseases for Gliosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Gliosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1glioblastoma multiforme30.5CDK4, GJA1, PDGFRB, MGMT, EGFR, TP53
2sarcoma30.3TP53, PDGFRB, CDK4
3herpes simplex30.2GJA1
4astrocytoma30.1IDH1, PDGFRB, MGMT, EGFR, CDK4, GJA1
5meningioma30.0PDGFRB, PTEN, GFAP
6osteosarcoma30.0PDGFRB, TP53, GJA1, CDK4
7medulloblastoma30.0CDK4, GFAP, MGMT, TP53
8rhabdomyosarcoma29.8CDK4, GJA1, PDGFRB, TP53
9giant cell glioblastoma29.8GFAP, EGFR, PTEN
10oligodendroglioma29.8GFAP, MGMT, EGFR, PTEN
11pancreatic cancer29.8PDGFRB, MGMT, EGFR, NFKBIA
12chondrosarcoma29.8FGFR1, CDK4, NFKBIA, PDGFRB, FGFR3
13squamous cell carcinoma29.8FGFR3, MGMT, EGFR, NFKBIA, GJA1, PTEN
14melanoma29.8GJA1, PTEN, FGFR3, FGFR1, EPHB6, CDK4
15cerebritis10.5
16adult brainstem gliosarcoma10.2
17neurofibromatosis10.1
18meningitis10.1
19adenoid cystic carcinoma10.0
20adenoiditis10.0
21leiomyoma10.0GJA1
22gastrointestinal stromal tumor10.0PDGFRB
23paraganglioma10.0GFAP
24fibrosarcoma10.0PDGFRB
25seminoma10.0GJA1
26gliomatosis cerebri10.0GFAP, PTEN
27myelofibrosis10.0PDGFRB
28gemistocytic astrocytoma10.0PTEN, GFAP
29hepatitis10.0TFRC
30myeloid leukemia10.0TFRC, CDK4
31chordoma10.0PDGFRB, GFAP
32anaplastic ependymoma10.0GFAP, PTEN
33hemangioblastoma10.0GFAP
34salivary gland cancer10.0PPARG
35peutz-jeghers syndrome10.0PTEN
36amyotrophic lateral sclerosis10.0GFAP, TFRC
37neurofibroma10.0PDGFRB
38pituitary tumors10.0PPARG
39gallbladder cancer10.0TP53
40oligoastrocytoma10.0GFAP, MGMT
41tuberous sclerosis10.0PDGFRB, GFAP, PTEN
42choriocarcinoma10.0PPARG
43neuroblastoma10.0TP53, EPHB6
44lipoma10.0CDK4, PTEN
45malignant mesothelioma10.0CDK4, PDGFRB
46cholangiocarcinoma10.0TP53
47pulmonary fibrosis10.0PDGFRB, PPARG
48li-fraumeni syndrome10.0PTEN, TP53
49nelson syndrome10.0PPARG
50pituitary adenoma10.0PPARG, MGMT, CDK4

Graphical network of the top 20 diseases related to Gliosarcoma:



Diseases related to gliosarcoma

Clinical Features for Gliosarcoma

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Drugs & Therapeutics for Gliosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gliosarcoma

Drug clinical trials:

Search ClinicalTrials for Gliosarcoma

Search NIH Clinical Center for Gliosarcoma

Search CenterWatch for Gliosarcoma

Genetic Tests for Gliosarcoma

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Anatomical Context for Gliosarcoma

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32MalaCards
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MalaCards organs/tissues related to Gliosarcoma:

32
Brain, Spinal cord, Bone, Smooth muscle, Lung, Nk cells, T cells, Thalamus, Pineal

Animal Models for Gliosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gliosarcoma:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
embryogenesis phenotype
MP:000538010.4PPARG, TACC3, GJA1
2
hearing/vestibular/ear phenotype
MP:000537710.3GJA1, FGFR3
3
skeleton phenotype
MP:000539010.3GJA1, FGFR3, FGFR1, EPHB6
4
vision/eye phenotype
MP:000539110.2PPARG, EGFR, FGFR3, GJA1, GFAP
5
renal/urinary system phenotype
MP:000536710.2PPARG, EGFR, EPHB6, FGFR1, FGFR3
6
endocrine/exocrine gland phenotype
MP:000537910.2PDGFRB, MGMT, CDK4, FGFR1, TP53
7
integument phenotype
MP:001077110.0NFKBIA, CDK4, EPHB6, FGFR1, GJA1, PTEN
8
muscle phenotype
MP:000536910.0PDGFRB, CDK4, FGFR1, GJA1, GFAP, TP53
9
nervous system phenotype
MP:00036319.9PPARG, TFRC, CDK4, GJA1, GFAP
10
reproductive system phenotype
MP:00053899.9EGFR, EPHB6, FGFR3, PTEN, TP53
11
craniofacial phenotype
MP:00053829.8LZTR1, PDGFRB, EGFR, FGFR1, FGFR3, TACC3
12
tumorigenesis
MP:00020069.8PPARG, MGMT, EGFR, CDK4, EPHB6, FGFR3
13
no phenotypic analysis
MP:00030129.7PPARG, MGMT, EGFR, EPHB6, FGFR1, FGFR3
14
digestive/alimentary phenotype
MP:00053819.6PDGFRB, TFRC, EGFR, CDK4, EPHB6, FGFR1
15
homeostasis/metabolism phenotype
MP:00053769.6IDH1, LZTR1, PDGFRB, MGMT, TFRC, NFKBIA
16
normal phenotype
MP:00028739.5PDGFRB, PPARG, EGFR, NFKBIA, EPHB6, FGFR1
17
cardiovascular system phenotype
MP:00053859.5PDGFRB, PPARG, TFRC, EGFR, CDK4, FGFR1
18
liver/biliary system phenotype
MP:00053709.4PPARG, TFRC, EGFR, CDK4, TACC3, PTEN
19
hematopoietic system phenotype
MP:00053979.3EGFR, TFRC, PPARG, PDGFRB, IDH1, NFKBIA
20
behavior/neurological phenotype
MP:00053869.3PPARG, CDK4, EPHB6, FGFR1, FGFR3, TACC3
21
cellular phenotype
MP:00053849.2CDK4, NFKBIA, EGFR, TFRC, PPARG, PDGFRB
22
growth/size phenotype
MP:00053789.2CDK4, NFKBIA, EGFR, TFRC, PPARG, PDGFRB
23
immune system phenotype
MP:00053879.2TP53, IDH1, PDGFRB, PPARG, TFRC, EGFR
24
mortality/aging
MP:00107689.2EGFR, TFRC, MGMT, PPARG, PDGFRB, LZTR1

Publications for Gliosarcoma

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50PubMed
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Articles related to Gliosarcoma:

(show top 50)    (show all 298)
idTitleAuthorsYear
1
Quantification of microvascular cerebral blood flux and late-stage tumor compartmentalization in 9L gliosarcoma using flow enhanced MRI. (23335424)
2013
2
The case of a patient affected by primary gliosarcoma and neuroendocrine pancreatic cancer with prolonged survival. (24158079)
2013
3
Primary gliosarcoma of the brain: radiologic and histopathologic features. (24355182)
2013
4
Secondary gliosarcoma with massive invasion of meninges, skull base, and soft tissue, and systemic metastasis. (23743158)
2013
5
Administration-dependent efficacy of ferrociphenol lipid nanocapsules for the treatment of intracranial 9L rat gliosarcoma. (21536115)
2012
6
Sarcoma arising as a distinct nodule within glioblastoma: a morphological and molecular perspective on gliosarcoma. (21533839)
2011
7
Molecular cytogenetic analysis of a gliosarcoma with osseous metaplasia. (21555877)
2011
8
Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients. (19817543)
2010
9
Gliosarcoma: a rare variant of glioblastoma multiforme. (21381591)
2010
10
The radiation response of cells from 9L gliosarcoma tumours is correlated with [F18]-EF5 uptake. (19995239)
2009
11
Congenital gliosarcoma: detailed clinicopathologic documentation of a rare neoplasm. (19883237)
2009
12
Adult gliosarcoma: epidemiology, natural history, and factors associated with outcome. (18780813)
2009
13
Gliosarcoma: an audit from a single institution in India of 24 post-irradiated cases over 15 years. (19052388)
2008
14
Epithelial and pseudoepithelial differentiation in glioblastoma and gliosarcoma: a comparative morphologic and molecular genetic study. (18816605)
2008
15
Magnetic resonance imaging of primary cerebral gliosarcoma: a report of 15 cases. (18766496)
2008
16
Infantile gliosarcoma. (18392424)
2008
17
Immunohistochemistry of gliosarcoma with liposarcomatous differentiation. (18477220)
2008
18
Gliosarcoma arising in oligodendroglial tumors ("oligosarcoma"): a clinicopathologic study. (17325476)
2007
19
Spheres isolated from 9L gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells. (17412894)
2007
20
Evaluation of in vitro and in vivo antitumor activity of BCNU-loaded PLGA wafer against 9L gliosarcoma. (15567315)
2005
21
Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy. (15362932)
2004
22
Gliosarcoma with epithelial differentiation: immunohistochemical and molecular characterization. A case report and review of the literature. (15148503)
2004
23
Primary cerebral gliosarcoma: a case presentation with review of the literature. (17415858)
2004
24
A cyclooxygenase-2 (COX-2) inhibitor compared with dexamethasone in a survival study of rats with intracerebral 9L gliosarcomas. (11772429)
2002
25
Gliosarcoma: a clinical study. (11578729)
2001
26
Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis. (11594506)
2001
27
Gliosarcoma with thallium-201 SPECT. (11108172)
2000
28
Cytokine gene therapy of gliomas: induction of reactive CD4+ T cells by interleukin-4-transfected 9L gliosarcoma is essential for protective immunity. (10811123)
2000
29
Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model. (9080471)
1997
30
Copper chelation inhibits tumor angiogenesis in the experimental 9L gliosarcoma model. (7477781)
1995
31
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents. (7591895)
1995
32
Influence of an anti-angiogenic treatment on 9L gliosarcoma: oxygenation and response to cytotoxic therapy. (7768649)
1995
33
Unusual evolution and computerized tomographic appearance of a gliosarcoma. (8087741)
1994
34
Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection. (8058777)
1994
35
Effects of nimodipine and dexamethasone on low-level CO2 laser-induced release of 51chromium from canine 2C5 gliosarcoma cells. (7885173)
1994
36
Relationship of perfusion to edema in the 9L gliosarcoma. (8410147)
1993
37
Tumor uptake of 99mTc-MIBI and 201Tl by a 9L gliosarcoma brain tumor model in rats. (8401378)
1993
38
Establishment of a new cell line derived from a human gliosarcoma. (1545891)
1992
39
Effects of gamma-interferon on major histocompatibility complex antigen expression and lymphocytic infiltration in the 9L gliosarcoma brain tumor model: implications for strategies of immunotherapy. (1735769)
1992
40
31P magnetic resonance spectroscopy is sensitive to tumor hypoxia: perfusion and oxygenation of rat 9L gliosarcoma after treatment with BCNU. (1911098)
1991
41
Cerebellar gliosarcoma: report of a probable radiation-induced neoplasm. (2058514)
1991
42
Decreased susceptibility of lined human gliosarcoma cells to lymphokine-activated killer cell cytolysis by gamma-interferon treatment. (2137025)
1990
43
Analysis of interleukin 2 and various effector cell populations in adoptive immunotherapy of 9L rat gliosarcoma: allogeneic cytotoxic T lymphocytes prevent tumor take. (2263613)
1990
44
Thorotrast-associated gliosarcoma. Including comments on thorotrast use and review of sequelae with particular reference to lesions of the central nervous system. (3289727)
1988
45
In vivo 31P nuclear magnetic resonance spectroscopy of subcutaneous 9L gliosarcoma: effects of tumor growth and treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea on tumor bioenergetics and histology. (3416313)
1988
46
Contribution of histiocytic cells to sarcomatous development of the gliosarcoma. An immunohistochemical study. (3111162)
1987
47
Establishment and characterization of a cell line from a human gliosarcoma. (3019542)
1986
48
Effect of hematoporphyrin derivative photoradiation therapy on survival in the rat 9L gliosarcoma brain-tumor model. (2932542)
1985
49
Radiation sensitivity of 9L gliosarcoma cells at different oxygen pressures. (6740476)
1984
50
DNA damage in the intracerebral rat gliosarcoma 9L treated with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. (908019)
1977

Genetic Variations for Gliosarcoma

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Expression for genes affiliated with Gliosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gliosarcoma

Search GEO for disease gene expression data for Gliosarcoma.

Pathways for genes affiliated with Gliosarcoma

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Sources:
51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 59Tocris Bioscience, 53Reactome, 52R&D Systems
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Pathways related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
TGF-Beta Pathway51
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10.3EPHB6
2
NF-KappaB Family Pathway51
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10.2FGFR3, FGFR1, NFKBIA
3
Angiogenesis4
10.2FGFR3, FGFR1, PDGFRB
4
Tyrosine Kinases / Adaptors4
10.2FGFR3, FGFR1, EPHB6
5
Selected targets of p5312
10.1MGMT, CDK4, TP53
6
DNA damage ATM/ATR regulation of G1/S checkpoint12
10.1TP53, CDK4, NFKBIA
7
CREB Pathway51
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10.1FGFR3, EPHB6, PDGFRB
8
Development IGF-RI signaling12
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10.1TP53, PTEN, NFKBIA
9
Validated targets of C-MYC transcriptional activation37
10.1TFRC, CDK4, TP53
10
p53 signaling pathway29
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10.1TP53, PTEN, CDK4
11
Aurora A signaling37
10.1TP53, TACC3, TACC1, NFKBIA
12
Alzheimers Disease Pathway51
10.1PDGFRB, EGFR, FGFR1, FGFR3
13
Regulation of Actin Cytoskeleton37
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10.1FGFR3, FGFR1, EGFR, PDGFRB
14
Sorafenib Pharmacodynamics49
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10.1PDGFRB, EGFR, FGFR1, FGFR3
15
Chronic myeloid leukemia29
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10.0EGFR, NFKBIA, CDK4, TP53
16
Integrated Breast Cancer Pathway37
10.0EGFR, CDK4, PTEN, TP53
17
HTLV-I infection29
10.0PDGFRB, NFKBIA, CDK4, TP53
18
Toll-like receptor signaling pathway37
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10.0NFKBIA, CDK4, PTEN, TP53
19
Small cell lung cancer29
10.0NFKBIA, CDK4, PTEN, TP53
20
MAPK signaling pathway37
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10.0TP53, FGFR3, FGFR1, EGFR, PDGFRB
21
Glioma29
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9.9PDGFRB, NFKBIA, FGFR1, FGFR3, TP53
22
Actin Nucleation by ARP-WASP Complex51
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9.9PDGFRB, EGFR, EPHB6, FGFR1, FGFR3
23
Nanog in Mammalian ESC Pluripotency51
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9.9PDGFRB, EGFR, EPHB6, FGFR1, FGFR3
24
MicroRNAs in cancer29
9.9PDGFRB, EGFR, FGFR3, PTEN, TP53
25
Spinal Cord Injury37
9.9EGFR, CDK4, GJA1, GFAP, TP53
26
Development HGF signaling pathway12
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9.9PDGFRB, EGFR, NFKBIA, PTEN, TP53
27
Apoptosis Pathway59
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9.9PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, TP53
28
PTEN Pathway51
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9.8PDGFRB, EGFR, FGFR1, FGFR3, PTEN, TP53
29
Signaling by FGFR53
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
30
PAK Pathway51
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
31
NFAT and Cardiac Hypertrophy51
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
32
Fc epsilon receptor (FCERI) signaling53
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
33
Signaling by the B Cell Receptor (BCR)53
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
34
PIP3 activates AKT signaling53
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9.8PDGFRB, EGFR, FGFR1, FGFR3, GFAP, PTEN
35
Activation of cAMP-Dependent PKA51
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9.8PDGFRB, EGFR, NFKBIA, EPHB6, FGFR1, FGFR3
36
GPCR Pathway51
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9.8NFKBIA, CDK4, EPHB6, FGFR1, FGFR3, TP53
37
Integrated Pancreatic Cancer Pathway37
9.8EGFR, NFKBIA, CDK4, FGFR1, PTEN, TP53
38
Glioblastoma Multiforme51
9.8PDGFRB, MGMT, EGFR, CDK4, PTEN, TP53
39
PEDF Induced Signaling51
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9.7PDGFRB, EGFR, NFKBIA, EPHB6, FGFR1, FGFR3
40
Akt Signaling Pathway 52
9.7TP53, PDGFRB, EGFR, CDK4, FGFR1, FGFR3
41
PI3K-Akt signaling pathway29
9.7PDGFRB, EGFR, CDK4, FGFR1, FGFR3, PTEN
42
Akt Signaling51
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9.7PDGFRB, EGFR, EPHB6, FGFR1, FGFR3, PTEN
43
Apoptotic Pathways in Synovial Fibroblasts51
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9.6PDGFRB, PPARG, EGFR, NFKBIA, FGFR1, FGFR3
44
Pathways in cancer29
9.5PDGFRB, PPARG, EGFR, NFKBIA, CDK4, FGFR1
45
Rho Family GTPases51
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9.3PDGFRB, EGFR, NFKBIA, CDK4, EPHB6, FGFR1

Compounds for genes affiliated with Gliosarcoma

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8GFAP
2cycloheximide4410.6GJA1, TFRC
3bcnu4410.4MGMT, GFAP, EGFR, TP53
4serine4410.4NFKBIA, FGFR3, TACC3, GJA1, GFAP
5suberoylanilide hydroxamic acid4410.4PPARG, TP53, FGFR1, EGFR, NFKBIA
6bortezomib44 1111.3TP53, PTEN, FGFR3, NFKBIA, EGFR
7topotecan44 1111.3PDGFRB, MGMT, EGFR, TP53
8thymidylate4410.3MGMT, CDK4, NFKBIA, EGFR, TP53
9gemcitabine44 49 1112.3TP53, PDGFRB, PTEN, NFKBIA, EGFR
10pge24410.2PTEN, EGFR
11dexamethasone44 49 28 1113.2MGMT, GJA1, CDK4, NFKBIA, GFAP
12su54164410.2PDGFRB, FGFR1, EGFR
13curcumin4410.2MGMT, TP53, CDK4, NFKBIA, EGFR, PPARG
14h2o24410.2FGFR1, PTEN, NFKBIA, PDGFRB
15flavopiridol44 1111.2CDK4, PDGFRB, TP53, EGFR
16bromodeoxyuridine4410.2NFKBIA, CDK4, FGFR1, PDGFRB, GJA1, GFAP
17imatinib44 49 1112.2PDGFRB, PTEN, FGFR3, EGFR, FGFR1
18retinoid4410.1PPARG, CDK4, TP53, EGFR, NFKBIA, GJA1
19doxycycline44 1111.1NFKBIA, GJA1, TFRC, GFAP
20sb 20358044 5911.1TP53, GJA1, PPARG, EGFR, NFKBIA, CDK4
21gw966244 2811.1GJA1, PPARG, PTEN
22ly2940024410.1NFKBIA, GJA1, TFRC, CDK4, PDGFRB, PPARG
23phosphotyrosine4410.1FGFR3, FGFR1, CDK4, EGFR, PDGFRB, GJA1
24n acetylcysteine4410.1TP53, CDK4, NFKBIA, EGFR, TFRC, PPARG
25calcitriol44 59 11 2413.1TFRC, NFKBIA, CDK4, PDGFRB, PTEN, GJA1
265fluorouracil4410.1MGMT, NFKBIA, PTEN, TP53, CDK4, EGFR
27agar4410.1PTEN, FGFR1, CDK4, PDGFRB, EGFR, GFAP
28pd 98,0594410.1FGFR1, PTEN, EGFR, NFKBIA, CDK4, GJA1
29methionine4410.1PTEN, GFAP, MGMT, PDGFRB, GJA1, FGFR1
30rapamycin4410.0EGFR, PPARG, TFRC, PDGFRB, NFKBIA, CDK4
31glucose4410.0NFKBIA, FGFR1, GFAP, PTEN, MGMT, PPARG
32vitamin d4410.0NFKBIA, CDK4, PDGFRB, PPARG, TFRC, PTEN
33thymidine44 2411.0GJA1, GFAP, TP53, TFRC, CDK4, MGMT
34paclitaxel44 49 1112.0TP53, PTEN, PDGFRB, EGFR, NFKBIA, CDK4
35carboplatin44 49 1111.9MGMT, CDK4, EGFR, TP53
36oligonucleotide449.9CDK4, TP53, PDGFRB, NFKBIA, MGMT, FGFR1
37proline449.9TP53, GJA1, NFKBIA, PDGFRB, MGMT, CDK4
38doxorubicin44 49 1111.9PTEN, MGMT, TFRC, EGFR, NFKBIA, CDK4
39phosphatidylinositol449.8PTEN, GJA1, NFKBIA, FGFR1, CDK4, EGFR
40progesterone44 59 28 11 2413.8MGMT, FGFR1, GFAP, TP53, PTEN, GJA1
41paraffin449.8EGFR, FGFR3, GJA1, PDGFRB, MGMT, TP53
42alanine449.8PTEN, NFKBIA, CDK4, GJA1, PDGFRB, PPARG
43testosterone44 59 11 2412.7PDGFRB, NFKBIA, CDK4, FGFR1, EGFR, GJA1
44cisplatin44 49 59 1112.7PTEN, TFRC, NFKBIA, GFAP, GJA1, CDK4
45cysteine449.7FGFR3, TFRC, MGMT, PDGFRB, NFKBIA, CDK4
46gefitinib44 49 1111.7EGFR, PDGFRB, PTEN, CDK4
47genistein44 28 59 2 11 2414.7PTEN, NFKBIA, GFAP, GJA1, FGFR1, CDK4
48tyrosine449.6PTEN, GFAP, GJA1, EGFR, FGFR1, NFKBIA
49retinoic acid44 2410.5GJA1, NFKBIA, PTEN, TP53, PDGFRB, EGFR
50vegf449.5GFAP, GJA1, FGFR3, FGFR1, CDK4, NFKBIA

GO Terms for genes affiliated with Gliosarcoma

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16Gene Ontology
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Cellular components related to Gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.7FGFR3, FGFR1, TFRC, PDGFRB
2cytosolGO:0058299.5PPARG, NFKBIA, CDK4, FGFR1, GJA1, GFAP

Biological processes related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:01051810.6FGFR3, FGFR1
2positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.6FGFR3, FGFR1
3interkinetic nuclear migrationGO:02202710.5TACC3, TACC1
4positive regulation of phospholipase C activityGO:01086310.5FGFR1, PDGFRB
5positive regulation of MAP kinase activityGO:04340610.5FGFR1, EGFR, PDGFRB
6peptidyl-tyrosine phosphorylationGO:01810810.5PDGFRB, FGFR1, FGFR3
7MAPK cascadeGO:00016510.4EGFR, FGFR1, FGFR3
8protein autophosphorylationGO:04677710.4PDGFRB, EGFR, FGFR1, FGFR3
9regulation of peptidyl-tyrosine phosphorylationGO:05073010.4EGFR, PDGFRB
10phosphatidylinositol-mediated signalingGO:04801510.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
11fibroblast growth factor receptor signaling pathwayGO:00854310.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
12response to toxic substanceGO:00963610.3PDGFRB, MGMT, CDK4
13epidermal growth factor receptor signaling pathwayGO:00717310.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
14in utero embryonic developmentGO:00170110.3PDGFRB, FGFR1, GJA1, TP53
15negative regulation of macrophage derived foam cell differentiationGO:01074510.3NFKBIA, PPARG
16positive regulation of ERK1 and ERK2 cascadeGO:07037410.2PDGFRB, EGFR, FGFR3
17response to hyperoxiaGO:05509310.2CDK4, PDGFRB
18regulation of microtubule-based processGO:03288610.2TACC3, TACC1
19Fc-epsilon receptor signaling pathwayGO:03809510.2PTEN, FGFR3, FGFR1, NFKBIA, EGFR, PDGFRB
20neurotrophin TRK receptor signaling pathwayGO:04801110.2PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
21negative regulation of apoptotic processGO:04306610.2EGFR, NFKBIA, FGFR1, FGFR3, PTEN, TP53
22positive regulation of cell proliferationGO:00828410.1PDGFRB, EGFR, CDK4, FGFR1, FGFR3, PTEN
23innate immune responseGO:04508710.1PDGFRB, PPARG, EGFR, NFKBIA, FGFR1, FGFR3
24cytoplasmic sequestering of transcription factorGO:04299410.0TACC3, NFKBIA

Molecular functions related to Gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00500710.2FGFR3, FGFR1
2protein tyrosine kinase activityGO:00471310.2FGFR3, FGFR1, EGFR, PDGFRB
3enzyme bindingGO:01989910.0PPARG, EGFR, NFKBIA, PTEN, TP53
4ATP bindingGO:0055249.7TP53, FGFR3, FGFR1, EPHB6, CDK4, EGFR
5identical protein bindingGO:0428029.6TFRC, EGFR, NFKBIA, FGFR1, TP53
6protein bindingGO:0055159.0PDGFRB, PPARG, TFRC, EGFR, NFKBIA, CDK4

Products for genes affiliated with Gliosarcoma

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Sources for Gliosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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