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MCID: GLS001
MIFTS: 53

Gliosarcoma malady

Neuronal, Cancer categories
46 genes, 8 tissues, 136 related diseases, clinical trials.

Summaries for Gliosarcoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain... more...

MalaCards: Gliosarcoma, also known as glioblastoma with a sarcomatous component, is related to astrocytoma and ependymoma. An important gene associated with Gliosarcoma is SEPT14 (septin 14), and among its related pathways are TGF-Beta Pathway and NF-KappaB Family Pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and smooth muscle, and related mouse phenotypes are embryogenesis and hearing/vestibular/ear.

Aliases & Classifications for Gliosarcoma

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
gliosarcoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

gliosarcoma 8 43 10 45 49 61
glioblastoma with a sarcomatous component 8
glioblastoma with sarcomatous component 8
sarcomatous glioblastoma 43


External Ids:

Disease Ontology8 DOID:3071
MeSH35 D018316
NCIt40 C3796

Related Diseases for Gliosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Gliosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.2TP53, IDH1, PDGFRB, MGMT, EGFR, NFKBIA
2ependymoma30.1MGMT, EGFR, GFAP
3anaplastic ependymoma29.9GFAP, PTEN
4pilocytic astrocytoma29.9IDH1, PDGFRB, MGMT, CDK4, GFAP, PTEN
5giant cell glioblastoma29.9EGFR, GFAP, PTEN
6anaplastic astrocytoma29.9TP53, PTEN, GFAP, PDGFRB, MGMT, EGFR
7squamous cell carcinoma29.9MGMT, EGFR, NFKBIA, CDK4, FGFR3, GJA1
8adult brainstem gliosarcoma10.2
9hypoxia10.2
10neurofibromatosis10.2
11chondroblastic osteosarcoma10.1
12adenoid cystic carcinoma10.1
13leiomyoma10.0GJA1
14gastrointestinal stromal tumor10.0PDGFRB
15paraganglioma10.0GFAP
16herpes simplex10.0GJA1
17fibrosarcoma10.0PDGFRB
18seminoma10.0GJA1
19gliomatosis cerebri10.0PTEN, GFAP
20myelofibrosis10.0PDGFRB
21gemistocytic astrocytoma10.0GFAP, PTEN
22hepatitis10.0TFRC
23myeloid leukemia10.0TFRC, CDK4
24chordoma10.0PDGFRB, GFAP
25hemangioblastoma10.0GFAP
26peutz-jeghers syndrome10.0PTEN
27salivary gland cancer10.0PPARG
28amyotrophic lateral sclerosis10.0GFAP, TFRC
29neurofibroma10.0PDGFRB
30pituitary tumors10.0PPARG
31meningioma10.0PDGFRB, GFAP, PTEN
32gallbladder cancer10.0TP53
33oligoastrocytoma10.0GFAP, MGMT
34tuberous sclerosis10.0PDGFRB, GFAP, PTEN
35choriocarcinoma10.0PPARG
36lipoma10.0PTEN, CDK4
37neuroblastoma10.0EPHB6, TP53
38malignant mesothelioma10.0CDK4, PDGFRB
39cholangiocarcinoma10.0TP53
40nelson syndrome10.0PPARG
41pulmonary fibrosis10.0PPARG, PDGFRB
42sarcoma10.0PDGFRB, CDK4, TP53
43li-fraumeni syndrome10.0TP53, PTEN
44pituitary adenoma10.0PPARG, MGMT, CDK4
45endometriosis10.0TFRC, PTEN
46biliary tract cancer10.0EGFR
47acute leukemia10.0FGFR1, TFRC
48leukoplakia10.0MGMT
49osteosarcoma10.0PDGFRB, CDK4, GJA1, TP53
50xeroderma pigmentosum10.0MGMT, TP53

Graphical network of the top 20 diseases related to Gliosarcoma:



Diseases related to gliosarcoma

Clinical Features for Gliosarcoma

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Drugs & Therapeutics for Gliosarcoma

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Gliosarcoma

Drug clinical trials:

Search ClinicalTrials for Gliosarcoma

Search NIH Clinical Center for Gliosarcoma

Search CenterWatch for Gliosarcoma

Genetic Tests for Gliosarcoma

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Anatomical Context for Gliosarcoma

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33MalaCards
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MalaCards organs/tissues related to Gliosarcoma:

33
Brain, Spinal cord, Smooth muscle, Lung, Nk cells, T cells, Thalamus, Pineal

Animal Models for Gliosarcoma or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Gliosarcoma:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
embryogenesis phenotype
MP:000538010.4PPARG, TACC3, GJA1
2
hearing/vestibular/ear phenotype
MP:000537710.3GJA1, FGFR3
3
skeleton phenotype
MP:000539010.3GJA1, FGFR3, FGFR1, EPHB6
4
vision/eye phenotype
MP:000539110.2PPARG, EGFR, FGFR3, GJA1, GFAP
5
renal/urinary system phenotype
MP:000536710.2PPARG, EGFR, EPHB6, FGFR1, FGFR3
6
endocrine/exocrine gland phenotype
MP:000537910.2PDGFRB, MGMT, CDK4, FGFR1, TP53
7
integument phenotype
MP:001077110.0NFKBIA, CDK4, EPHB6, FGFR1, GJA1, PTEN
8
muscle phenotype
MP:000536910.0PDGFRB, CDK4, FGFR1, GJA1, GFAP, TP53
9
nervous system phenotype
MP:00036319.9PPARG, TFRC, CDK4, GJA1, GFAP
10
reproductive system phenotype
MP:00053899.9EGFR, EPHB6, FGFR3, PTEN, TP53
11
craniofacial phenotype
MP:00053829.8LZTR1, PDGFRB, EGFR, FGFR1, FGFR3, TACC3
12
tumorigenesis
MP:00020069.8PPARG, MGMT, EGFR, CDK4, EPHB6, FGFR3
13
no phenotypic analysis
MP:00030129.7PPARG, MGMT, EGFR, EPHB6, FGFR1, FGFR3
14
digestive/alimentary phenotype
MP:00053819.6PDGFRB, TFRC, EGFR, CDK4, EPHB6, FGFR1
15
homeostasis/metabolism phenotype
MP:00053769.6IDH1, LZTR1, PDGFRB, MGMT, TFRC, NFKBIA
16
normal phenotype
MP:00028739.5PDGFRB, PPARG, EGFR, NFKBIA, EPHB6, FGFR1
17
cardiovascular system phenotype
MP:00053859.5PDGFRB, PPARG, TFRC, EGFR, CDK4, FGFR1
18
liver/biliary system phenotype
MP:00053709.4PPARG, TFRC, EGFR, CDK4, TACC3, PTEN
19
hematopoietic system phenotype
MP:00053979.3EGFR, TFRC, PPARG, PDGFRB, IDH1, NFKBIA
20
behavior/neurological phenotype
MP:00053869.3PPARG, CDK4, EPHB6, FGFR1, FGFR3, TACC3
21
cellular phenotype
MP:00053849.2CDK4, NFKBIA, EGFR, TFRC, PPARG, PDGFRB
22
growth/size phenotype
MP:00053789.2CDK4, NFKBIA, EGFR, TFRC, PPARG, PDGFRB
23
immune system phenotype
MP:00053879.2TP53, IDH1, PDGFRB, PPARG, TFRC, EGFR
24
mortality/aging
MP:00107689.2EGFR, TFRC, MGMT, PPARG, PDGFRB, LZTR1

Publications for Gliosarcoma

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51PubMed
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Articles related to Gliosarcoma:

(show top 50)    (show all 302)
idTitleAuthorsYear
1
Pure intraventricular origin of gliosarcoma - a rare entity. (23756982)
2013
2
Gliosarcoma metastatic to the leptomeninges and dura. (21883625)
2013
3
Gliosarcoma arising from an oligodendroglioma (oligosarcoma). (23254140)
2013
4
De novo gliosarcoma occurring in the posterior fossa of a 11-year-old girl. (22939178)
2012
5
Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02. (23099651)
2012
6
Clinicopathologic and genomic features of gliosarcomas. (22270848)
2012
7
Gliosarcoma of the pineal region with cerebellar metastasis: case illustration. (22338845)
2012
8
Amplification of the STOML3, FREM2, and LHFP genes is associated with mesenchymal differentiation in gliosarcoma. (22538188)
2012
9
Gliosarcoma arising from a fibrillary astrocytoma. (21737284)
2011
10
O6-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications. (20556478)
2011
11
Gliosarcoma of the cerebellar hemisphere: a case report and review of the literature. (20808702)
2010
12
Metastatic gliosarcoma due to iatrogenic contamination during the surgery of gliosarcoma. (20934145)
2010
13
Gliosarcoma: clinical experiences and additional information with MR spectroscopy. (19215667)
2009
14
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. (19075262)
2009
15
Gliosarcoma with chondroblastic osteosarcomatous differentation: report of two case with clinicopathologic and immunohistochemical features. (19847765)
2009
16
Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing. (18263945)
2008
17
Gliosarcoma with melanocytic differentiation. (17641902)
2008
18
Overexpression of Na/Ca exchanger reduces viability and proliferation of gliosarcoma cells. (17446487)
2007
19
Gliosarcoma with chondroid and osseous differentiation. (17319288)
2007
20
Gliosarcoma cell death after radiosurgery in a rat model. (16015490)
2005
21
Gliosarcoma occurring 8 years after treatment for a medulloblastoma. (14704813)
2004
22
Synergistic cytotoxicity of the ribonucleotide reductase inhibitor didox (3,4-dihydroxy-benzohydroxamic acid) and the alkylating agent carmustine (BCNU) in 9L rat gliosarcoma cells and DAOY human medulloblastoma cells. (15133626)
2004
23
Primary C1-2, intradural, extramedullary meningeal sarcoma with glial fibrillary acidic protein-immunoreactive components: a spinal gliosarcoma? Case report and review of the literature. (12450287)
2002
24
Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma. (11772427)
2002
25
Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy. (11772430)
2002
26
Postradiation gliosarcoma with osteosarcomatous components. (11512585)
2001
27
Gliosarcoma associated with a huge cyst--case report. (11109796)
2000
28
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. (9628761)
1998
29
Gliosarcoma: an immunohistochemical, ultrastructural and fluorescence in situ hybridization study. (9736406)
1998
30
Gliosarcoma--case report and review of the literature. (9490099)
1997
31
Gliosarcoma. A study of 13 tumors, including p53 and CD34 immunohistochemistry. (9126039)
1997
32
Postirradiated and nonirradiated gliosarcoma: immunophenotypical profile. (8951202)
1996
33
A clinical and pathological study of gliosarcoma]. (9275662)
1996
34
Clinicopathologic features of primary and postirradiation cerebral gliosarcoma. (7773942)
1995
35
Suppression of tumor growth in experimental 9L gliosarcoma model by copper depletion. (7770105)
1995
36
Low-level CO2 laser-induced release of 51chromium from canine 2C5 gliosarcoma cells. (8264321)
1993
37
Mechanism of interferon gamma-induced protection of human gliosarcoma cells from lymphokine-activated killer lysis: division of lymphokine-activated killer cells into natural killer- and T-like cells. (1407434)
1992
38
Epithelial and melanoma antigens in gliosarcoma. An immunohistochemical study. (1594490)
1992
39
Distribution of misonidazole adducts in 9L gliosarcoma tumors and spheroids: implications for oxygen distribution. (1617656)
1992
40
Gliosarcoma with cranial penetration and extension to the maxillary sinus. (4068129)
1985
41
Gliosarcoma at the site of a surgically treated Actinomyces cerebral abscess. (6514161)
1984
42
Selective peripancreatic sarcoma metastases from primary gliosarcoma. Case report. (6747700)
1984
43
Immunogenetic and immunologic aspects of gliosarcoma growth in rats. (6604839)
1983
44
Congenital malignant gliosarcoma. (6792889)
1981
45
Comparison of clonogenic cell assays after in vivo and in vitro treatment of 9L gliosarcoma. (6932943)
1980
46
Experimental brain tumor chemotherapy: DNA damage in the rat gliosarcoma 9L treated with CCNU. (583703)
1977
47
S1 nuclease from Aspergillus oryzae for the detection of DNA damage and repair in the gamma-irradiated intracerebral rat gliosarcoma 9L. (905506)
1977
48
Clinical and pathological study of 24 cases of gliosarcoma. (956876)
1976
49
Cell-mediated response to a rat gliosarcoma: the mode of action of lymphocytes and peritoneal cells. (4459736)
1974
50
Gliosarcoma in a Full-time Stillborn Foetus. (19985093)
1926

Genetic Variations for Gliosarcoma

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Expression for genes affiliated with Gliosarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gliosarcoma

Search GEO for disease gene expression data for Gliosarcoma.

Pathways for genes affiliated with Gliosarcoma

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Sources:
52QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 50PharmGKB, 60Tocris Bioscience, 54Reactome, 53R&D Systems
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Pathways related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
TGF-Beta Pathway52
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10.3EPHB6
2
NF-KappaB Family Pathway52
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10.2FGFR3, FGFR1, NFKBIA
3
Angiogenesis4
10.2FGFR3, FGFR1, PDGFRB
4
Tyrosine Kinases / Adaptors4
10.2FGFR3, FGFR1, EPHB6
5
Selected targets of p5312
10.1MGMT, CDK4, TP53
6
DNA damage ATM/ATR regulation of G1/S checkpoint12
10.1TP53, CDK4, NFKBIA
7
CREB Pathway52
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10.1FGFR3, EPHB6, PDGFRB
8
Development IGF-RI signaling12
Hide members
10.1TP53, PTEN, NFKBIA
9
Validated targets of C-MYC transcriptional activation38
10.1TFRC, CDK4, TP53
10
p53 signaling pathway30
Hide members
10.1TP53, PTEN, CDK4
11
Aurora A signaling38
10.1TP53, TACC3, TACC1, NFKBIA
12
Alzheimers Disease Pathway52
10.1PDGFRB, EGFR, FGFR1, FGFR3
13
Regulation of Actin Cytoskeleton38
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10.1FGFR3, FGFR1, EGFR, PDGFRB
14
Sorafenib Pharmacodynamics50
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10.1PDGFRB, EGFR, FGFR1, FGFR3
15
Chronic myeloid leukemia30
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10.0EGFR, NFKBIA, CDK4, TP53
16
Integrated Breast Cancer Pathway38
10.0EGFR, CDK4, PTEN, TP53
17
HTLV-I infection30
10.0PDGFRB, NFKBIA, CDK4, TP53
18
Toll-like receptor signaling pathway38
Hide members
10.0NFKBIA, CDK4, PTEN, TP53
19
Small cell lung cancer30
10.0NFKBIA, CDK4, PTEN, TP53
20
MAPK signaling pathway38
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10.0TP53, FGFR3, FGFR1, EGFR, PDGFRB
21
Glioma30
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9.9PDGFRB, NFKBIA, FGFR1, FGFR3, TP53
22
Actin Nucleation by ARP-WASP Complex52
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9.9PDGFRB, EGFR, EPHB6, FGFR1, FGFR3
23
Nanog in Mammalian ESC Pluripotency52
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9.9PDGFRB, EGFR, EPHB6, FGFR1, FGFR3
24
MicroRNAs in cancer30
9.9PDGFRB, EGFR, FGFR3, PTEN, TP53
25
Spinal Cord Injury38
9.9EGFR, CDK4, GJA1, GFAP, TP53
26
Development HGF signaling pathway12
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9.9PDGFRB, EGFR, NFKBIA, PTEN, TP53
27
Apoptosis Pathway60
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9.9PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, TP53
28
PTEN Pathway52
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9.8PDGFRB, EGFR, FGFR1, FGFR3, PTEN, TP53
29
Signaling by FGFR54
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
30
PAK Pathway52
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
31
NFAT and Cardiac Hypertrophy52
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
32
Fc epsilon receptor (FCERI) signaling54
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
33
Signaling by the B Cell Receptor (BCR)54
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9.8PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
34
PIP3 activates AKT signaling54
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9.8PDGFRB, EGFR, FGFR1, FGFR3, GFAP, PTEN
35
Activation of cAMP-Dependent PKA52
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9.8PDGFRB, EGFR, NFKBIA, EPHB6, FGFR1, FGFR3
36
GPCR Pathway52
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9.8NFKBIA, CDK4, EPHB6, FGFR1, FGFR3, TP53
37
Integrated Pancreatic Cancer Pathway38
9.8EGFR, NFKBIA, CDK4, FGFR1, PTEN, TP53
38
Glioblastoma Multiforme52
9.8PDGFRB, MGMT, EGFR, CDK4, PTEN, TP53
39
PEDF Induced Signaling52
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9.7PDGFRB, EGFR, NFKBIA, EPHB6, FGFR1, FGFR3
40
Akt Signaling Pathway 53
9.7TP53, PDGFRB, EGFR, CDK4, FGFR1, FGFR3
41
PI3K-Akt signaling pathway30
9.7PDGFRB, EGFR, CDK4, FGFR1, FGFR3, PTEN
42
Akt Signaling52
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9.7PDGFRB, EGFR, EPHB6, FGFR1, FGFR3, PTEN
43
Apoptotic Pathways in Synovial Fibroblasts52
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9.6PDGFRB, PPARG, EGFR, NFKBIA, FGFR1, FGFR3
44
Pathways in cancer30
9.5PDGFRB, PPARG, EGFR, NFKBIA, CDK4, FGFR1
45
Rho Family GTPases52
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9.3PDGFRB, EGFR, NFKBIA, CDK4, EPHB6, FGFR1

Compounds for genes affiliated with Gliosarcoma

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Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Gliosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8GFAP
2cycloheximide4510.6GJA1, TFRC
3bcnu4510.4MGMT, GFAP, EGFR, TP53
4serine4510.4NFKBIA, FGFR3, TACC3, GJA1, GFAP
5suberoylanilide hydroxamic acid4510.4PPARG, TP53, FGFR1, EGFR, NFKBIA
6bortezomib45 1111.3TP53, PTEN, FGFR3, NFKBIA, EGFR
7topotecan45 1111.3PDGFRB, MGMT, EGFR, TP53
8thymidylate4510.3MGMT, CDK4, NFKBIA, EGFR, TP53
9gemcitabine45 50 1112.3TP53, PDGFRB, PTEN, NFKBIA, EGFR
10pge24510.2PTEN, EGFR
11dexamethasone45 50 29 1113.2MGMT, GJA1, CDK4, NFKBIA, GFAP
12su54164510.2PDGFRB, FGFR1, EGFR
13curcumin4510.2MGMT, TP53, CDK4, NFKBIA, EGFR, PPARG
14h2o24510.2FGFR1, PTEN, NFKBIA, PDGFRB
15flavopiridol45 1111.2CDK4, PDGFRB, TP53, EGFR
16bromodeoxyuridine4510.2NFKBIA, CDK4, FGFR1, PDGFRB, GJA1, GFAP
17imatinib45 50 1112.2PDGFRB, PTEN, FGFR3, EGFR, FGFR1
18retinoid4510.1PPARG, CDK4, TP53, EGFR, NFKBIA, GJA1
19doxycycline45 1111.1NFKBIA, GJA1, TFRC, GFAP
20sb 20358045 6011.1TP53, GJA1, PPARG, EGFR, NFKBIA, CDK4
21gw966245 2911.1GJA1, PPARG, PTEN
22ly2940024510.1NFKBIA, GJA1, TFRC, CDK4, PDGFRB, PPARG
23phosphotyrosine4510.1FGFR3, FGFR1, CDK4, EGFR, PDGFRB, GJA1
24n acetylcysteine4510.1TP53, CDK4, NFKBIA, EGFR, TFRC, PPARG
25calcitriol45 60 11 2413.1TFRC, NFKBIA, CDK4, PDGFRB, PTEN, GJA1
265fluorouracil4510.1MGMT, NFKBIA, PTEN, TP53, CDK4, EGFR
27agar4510.1PTEN, FGFR1, CDK4, PDGFRB, EGFR, GFAP
28pd 98,0594510.1FGFR1, PTEN, EGFR, NFKBIA, CDK4, GJA1
29methionine4510.1PTEN, GFAP, MGMT, PDGFRB, GJA1, FGFR1
30rapamycin4510.0EGFR, PPARG, TFRC, PDGFRB, NFKBIA, CDK4
31glucose4510.0NFKBIA, FGFR1, GFAP, PTEN, MGMT, PPARG
32vitamin d4510.0NFKBIA, CDK4, PDGFRB, PPARG, TFRC, PTEN
33thymidine45 2411.0GJA1, GFAP, TP53, TFRC, CDK4, MGMT
34paclitaxel45 50 1112.0TP53, PTEN, PDGFRB, EGFR, NFKBIA, CDK4
35carboplatin45 50 1111.9MGMT, CDK4, EGFR, TP53
36oligonucleotide459.9CDK4, TP53, PDGFRB, NFKBIA, MGMT, FGFR1
37proline459.9TP53, GJA1, NFKBIA, PDGFRB, MGMT, CDK4
38doxorubicin45 50 1111.9PTEN, MGMT, TFRC, EGFR, NFKBIA, CDK4
39phosphatidylinositol459.8PTEN, GJA1, NFKBIA, FGFR1, CDK4, EGFR
40progesterone45 60 29 11 2413.8MGMT, FGFR1, GFAP, TP53, PTEN, GJA1
41paraffin459.8EGFR, FGFR3, GJA1, PDGFRB, MGMT, TP53
42alanine459.8PTEN, NFKBIA, CDK4, GJA1, PDGFRB, PPARG
43testosterone45 60 11 2412.7PDGFRB, NFKBIA, CDK4, FGFR1, EGFR, GJA1
44cisplatin45 50 60 1112.7PTEN, TFRC, NFKBIA, GFAP, GJA1, CDK4
45cysteine459.7FGFR3, TFRC, MGMT, PDGFRB, NFKBIA, CDK4
46gefitinib45 50 1111.7EGFR, PDGFRB, PTEN, CDK4
47genistein45 29 60 2 11 2414.7PTEN, NFKBIA, GFAP, GJA1, FGFR1, CDK4
48tyrosine459.6PTEN, GFAP, GJA1, EGFR, FGFR1, NFKBIA
49retinoic acid45 2410.5GJA1, NFKBIA, PTEN, TP53, PDGFRB, EGFR
50vegf459.5GFAP, GJA1, FGFR3, FGFR1, CDK4, NFKBIA

GO Terms for genes affiliated with Gliosarcoma

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Sources:
16Gene Ontology
See all sources

Cellular components related to Gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.7FGFR3, FGFR1, TFRC, PDGFRB
2cytosolGO:0058299.5PPARG, NFKBIA, CDK4, FGFR1, GJA1, GFAP

Biological processes related to Gliosarcoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:01051810.6FGFR3, FGFR1
2positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.6FGFR3, FGFR1
3interkinetic nuclear migrationGO:02202710.5TACC3, TACC1
4positive regulation of phospholipase C activityGO:01086310.5FGFR1, PDGFRB
5positive regulation of MAP kinase activityGO:04340610.5FGFR1, EGFR, PDGFRB
6peptidyl-tyrosine phosphorylationGO:01810810.5PDGFRB, FGFR1, FGFR3
7MAPK cascadeGO:00016510.4EGFR, FGFR1, FGFR3
8protein autophosphorylationGO:04677710.4PDGFRB, EGFR, FGFR1, FGFR3
9regulation of peptidyl-tyrosine phosphorylationGO:05073010.4EGFR, PDGFRB
10phosphatidylinositol-mediated signalingGO:04801510.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
11fibroblast growth factor receptor signaling pathwayGO:00854310.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
12response to toxic substanceGO:00963610.3PDGFRB, MGMT, CDK4
13epidermal growth factor receptor signaling pathwayGO:00717310.3PDGFRB, EGFR, FGFR1, FGFR3, PTEN
14in utero embryonic developmentGO:00170110.3PDGFRB, FGFR1, GJA1, TP53
15negative regulation of macrophage derived foam cell differentiationGO:01074510.3NFKBIA, PPARG
16positive regulation of ERK1 and ERK2 cascadeGO:07037410.2PDGFRB, EGFR, FGFR3
17response to hyperoxiaGO:05509310.2CDK4, PDGFRB
18regulation of microtubule-based processGO:03288610.2TACC3, TACC1
19Fc-epsilon receptor signaling pathwayGO:03809510.2PTEN, FGFR3, FGFR1, NFKBIA, EGFR, PDGFRB
20neurotrophin TRK receptor signaling pathwayGO:04801110.2PDGFRB, EGFR, NFKBIA, FGFR1, FGFR3, PTEN
21negative regulation of apoptotic processGO:04306610.2EGFR, NFKBIA, FGFR1, FGFR3, PTEN, TP53
22positive regulation of cell proliferationGO:00828410.1PDGFRB, EGFR, CDK4, FGFR1, FGFR3, PTEN
23innate immune responseGO:04508710.1PDGFRB, PPARG, EGFR, NFKBIA, FGFR1, FGFR3
24cytoplasmic sequestering of transcription factorGO:04299410.0TACC3, NFKBIA

Molecular functions related to Gliosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:00500710.2FGFR3, FGFR1
2protein tyrosine kinase activityGO:00471310.2FGFR3, FGFR1, EGFR, PDGFRB
3enzyme bindingGO:01989910.0PPARG, EGFR, NFKBIA, PTEN, TP53
4ATP bindingGO:0055249.7TP53, FGFR3, FGFR1, EPHB6, CDK4, EGFR
5identical protein bindingGO:0428029.6TFRC, EGFR, NFKBIA, FGFR1, TP53
6protein bindingGO:0055159.0PDGFRB, PPARG, TFRC, EGFR, NFKBIA, CDK4

Products for genes affiliated with Gliosarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gliosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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