Gliosis malady

Wikipedia: Gliosis is a nonspecific reactive change of glial cells in response to damage to the central nervous...⁴⁴ more...

MalaCards: Gliosis is related to alzheimer's disease and aids dementia complex. An important gene associated with Gliosis is GPSC (gliosis, familial progressive subcortical), and among its related pathways are Glutamic acid signaling and 14-3-3 Induced Intracellular Signaling. The compounds quinolinic acid and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and retina, and related mouse phenotypes are hematopoietic system and respiratory system.

gliosis 7 32 43

Diseases related to gliosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 571)

id	Related Disease	Score	Top Affiliating Genes
1	alzheimer's disease	30.4	APP, MAPT, NRG1, PRNP
2	aids dementia complex	27.3	S100B, ITIH4, MBP, IFNG, TAT, SLC1A2
3	periventricular leukomalacia	27.2	IL6, APP, MBP, SLC1A2
4	leukomalacia	27.2	IL6, APP, MBP, SLC1A2
5	immunodeficiency	26.5	PARK2, MPZ, ITIH4, IL6, AQP4, MBP
6	sleep apnea	25.9	S100B, IL6, CRP, HCRT, HCRTR2, GFAP
7	sudden infant death syndrome	25.4	SCN1B, CHAT, FOS, IL6, MAOB, IFNG
8	apnea	25.4	CHAT, S100B, IL6, ENO2, CRP, HCRT
9	parkinson's disease	25.2	CNTF, PARK2, CHAT, ITIH4, GRM5, APP
10	encephalomyelitis	24.7	CNTF, S100B, MPZ, IL6, AQP4, APP
11	spinal cord injury	24.2	CNTF, MPZ, FOS, IL6, AQP4, MBP
12	neurodegeneration	22.9	PIK3C3, CNTF, GCDH, PARK2, CHAT, BACE1
13	meningitis	21.5	S100B, MPZ, IL1A, IL6, AQP4, APP
14	dementia	21.2	PARK2, CHAT, BACE1, S100B, ATXN1, ITIH4
15	seizures	21.2	CNTF, PARK2, SCN1B, CHAT, S100B, FOS
16	astrocytoma	19.5	PARK2, S100B, ITIH4, FOS, IL1A, IL6
17	ischemia	19.3	CNTF, PARK2, CHAT, BACE1, S100B, FOS
18	retinitis	19.0	CNTF, CHAT, S100B, FOS, GRM5, IL1A
19	neuronitis	16.2	PIK3C3, CNTF, GCDH, PARK2, SCN1B, CHAT
20	cerebritis	15.8	CNTF, GCDH, PARK2, SCN1B, CHAT, BACE1
21	binswanger's disease	13.9	MAPT, GFAP, SYP
22	pineal gland cancer	13.9	ENO2, GFAP, SYP
23	papillary ependymoma	13.9	S100B, GFAP, SYP
24	subependymal giant cell astrocytoma	13.8	S100B, CRYAB, SYP
25	central neurocytoma	13.8	MAP2, GFAP, SYP
26	ewing's family of tumors	13.8	TNC, NGFR, GFAP, SYP
27	alexander disease	13.8	HSPB1, CRYAB, RPS27A, GFAP
28	melanotic neuroectodermal tumor	13.8	MBP, ENO2, GFAP
29	acute disseminated encephalomyelitis	13.8	CNTF, MPZ, AQP4, MBP, HCRT
30	dentatorubral-pallidoluysian atrophy	13.8	CALB2, RPS27A, GFAP, PVALB, SLC1A3
31	beriberi	13.8	APP, GFAP, TSPO, SLC1A3
32	chordoid glioma	13.8	S100B, GFAP, SYP
33	hirschsprung's disease	13.8	NGFR, SYP, ADCYAP1, GDNF
34	neuronal migration disorders	13.8	MAP2, CALB1, CALB2, PVALB
35	gangliocytoma	13.7	TH, PVALB, SYP
36	primary progressive aphasia	13.7	APP, MAPT, PRNP
37	neuronal ceroid-lipofuscinoses	13.7	CALB2, PVALB, SLC1A3
38	wernicke encephalopathy	13.7	MAPT, GFAP, TSPO, PRNP, SLC1A3
39	myofibrillar myopathy	13.7	CRYAB, RPS27A, SOD2
40	hyperammonemia with hypoornithinemia	13.7	CHAT, MAP2, GLS, GLUL, TSPO
41	merkel cell carcinoma	13.7	ENO2, MAP2, TNC, SYP
42	desmoplastic small round cell tumor	13.7	S100B, ENO2, CALB2, PDGFA, SYP
43	early-onset familial alzheimer disease	13.7	APP, MAPT, SNCA
44	olivopontocerebellar atrophy	13.7	MAP2, SNCA, TSPO
45	niemann-pick disease type c1	13.7	APP, MAPT, SNCA, HCRT
46	corticobasal degeneration	13.7	MAPT, SNCA, RPS27A, HCRT
47	esthesioneuroblastoma	13.7	S100B, ENO2, SYP
48	pineocytoma	13.7	S100B, MBP, ENO2, GFAP, SYP
49	prion disease	13.7	ITIH4, APP, MAPT, PRNP
50	spinocerebellar ataxia type 3	13.7	ATXN1, HSPB1, SOD2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to gliosis:

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MGI Mouse Phenotypes related to gliosis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.9	GJA1, CREB3L1, CNTF, GDNF, SOD2
2	respiratory system phenotype	MP:0005388	9.7	TH, HCRT, GLS, AQP4, C5, PARK2
3	other phenotype	MP:0005395	9.2	BACE1, APP, MAPT, HSPG2, GJA1, SOD2
4	endocrine/exocrine gland phenotype	MP:0005379	9.2	GRM5, IFNG, GJA1, NRG1
5	renal/urinary system phenotype	MP:0005367	9.1	SNCA, NGFR, MAOB, MAPT, AQP4, GCDH
6	no phenotypic analysis	MP:0003012	8.3	APP, AQP4, SCN1B, SLC1A3, PRNP, SYP
7	digestive/alimentary phenotype	MP:0005381	8.0	GFAP, AQP4, IFNG, HSPG2, CA2, SNCA
8	hearing/vestibular/ear phenotype	MP:0005377	8.0	NGFR, CYP19A1, CALB1, SLC1A3, SOD2, FOS
9	skeleton phenotype	MP:0005390	7.1	SNCA, CREB3L1, GJA1, TP53, CYP19A1, FOS
10	reproductive system phenotype	MP:0005389	6.8	PDHA1, SOD2, NRG1, PDGFA, GDNF, ADCYAP1
11	integument phenotype	MP:0010771	6.7	SNCA, TH, EGFR, GRM5, APP, TP53
12	liver/biliary system phenotype	MP:0005370	6.5	TH, SCO2, ITIH4, IL6, IFNG, HSPG2
13	normal phenotype	MP:0002873	6.1	APP, AGRP, MBP, MAPT, HSPB1, CALB2
14	immune system phenotype	MP:0005387	6.1	PIK3C3, IL6, MPZ, EGFR, CRYAB, CYP19A1
15	vision/eye phenotype	MP:0005391	5.8	GJA1, HSPG2, IFNG, MAPT, AQP4, IL6
16	nervous system phenotype	MP:0003631	5.4	GDNF, GALC, ADCYAP1, CP, SLC1A2, CYP19A1
17	cardiovascular system phenotype	MP:0005385	4.8	IL1A, CP, FGF9, PIK3C3, GDNF, GALC
18	muscle phenotype	MP:0005369	4.6	SCO2, GDNF, GJA1, HSPG2, IFNG, MAPT
19	growth/size phenotype	MP:0005378	4.5	SNCA, NTRK2, CYP19A1, TP53, GJA1, GLUL
20	mortality/aging	MP:0010768	4.3	GLS, GLUL, GJA1, TP53, NTRK2, GALC
21	homeostasis/metabolism phenotype	MP:0005376	3.7	GALC, ADCYAP1, C5, CP, SLC1A3, SOD2
22	cellular phenotype	MP:0005384	3.7	ITIH4, BACE1, IL6, MPZ, FOS, CNTF
23	behavior/neurological phenotype	MP:0005386	3.4	APP, PIK3C3, CNTF, AQP4, IL6, GRM5

Articles related to gliosis:

(show all 50)

id	Title	Authors	Year	Affiliating Genes
1	Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration. (20955765)	Wang L.... Wang F.	2011	PIK3C3
2	Computer-aided structure analysis of an epimerized de hydroepiandrosterone derivative and its biological effect in a model of reactiv e gliosis. (20064537)	Hoyk Z.... PA!rducz A.	2010	CYP19A1, GFAP
3	Overexpression of human S100B exacerbates cerebral am yloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. (19705461)	Mori T.... Town T.	2010	S100B
4	Withaferin A targets intermediate filaments glial fib rillary acidic protein and vimentin in a model of retinal gliosis. (20048155)	Bargagna-Mohan P.... Mohan R.	2010	GFAP
5	Massive gliosis induced by interleukin-6 suppresses A beta deposition in vivo: evidence against inflammation as a driving force for a myloid deposition. (19825975)	Chakrabarty P.... Das P.	2010	APP
6	The difference in gliosis induced by I^-amyloid and Ta u treatments in astrocyte cultures derived from senescence accelerated and norm al mouse strains. (19221889)	LA1 L.... Yew D.T.	2009	APP, MAPT
7	Conditional deletion of beta1-integrin in astroglia c auses partial reactive gliosis. (19373938)	Robel S.... GAPtz M.	2009	TNC, GFAP
8	Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions. (18784302)	Wu Q.... Palmiter R.D.	2008	AGRP
9	Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia. (18451356)	Mori T.... Town T.	2008	S100B
10	Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway. (18322086)	Gadea A.... Gallo V.	2008	GFAP
11	Blunted neurogenesis and gliosis due to transgenic ov erexpression of human soluble IL-1ra in the mouse. (18279308)	Spulber S.... Schultzberg M.	2008	GFAP
12	In vivo detection of thalamic gliosis: a pathoradiologic demonstration in familial fatal insomnia. (18413481)	Haik S.... Brandel J.P.	2008	PRNP
13	C-reactive protein as an indicator of aqueductal gliosis and hydrocephaly in neonatal meningitis. (18581011)	Hemmati F.... Pishva N.	2008	CRP
14	Non-invasive fluorescent imaging of gliosis in transgenic mice for profiling developmental neurotoxicity. (17350065)	Ho G.... Zhuo L.	2007	GFAP
15	Comparison of numerical change of epidermal growth factor receptor gene among pre- and postradiation glioma, and gliosis, and its clinical use. (18095139)	Okada Y.... Kim P.	2007	EGFR
16	Alterations of p53, BCL-2, and hMSH2 protein expression in the normal brain tissues, gliosis, and gliomas. (16875495)	Hussein M.R.... El-Rahman Y.G.	2006	TP53
17	Atypical gliosis in MA1ller cells of the slowly degenerating rds mutant mouse retina. (16154566)	Iandiev I.... Pannicke T.	2006	GFAP
18	Signaling from P2 nucleotide receptors to protein kinase cascades induced by CNS injury: implications for reactive gliosis and neurodegeneration. (15953814)	Neary J.T.... Kang Y.	2005	GFAP
19	Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. (15509549)	Gylys K.H.... Cole G.M.	2004	APP
20	Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. (15037694)	Ingelsson M.... Irizarry M.C.	2004	APP, GFAP, SYP
21	Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes. (15000761)	Floyd C.L.... Ellis E.F.	2004	HSPG2
22	Complement C5 in experimental autoimmune encephalomyelitis (EAE) facilitates remyelination and prevents gliosis. (12937147)	Weerth S.H.... Raine C.S.	2003	C5
23	Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy. (12946023)	Thannickal T.C.... Moore R.Y.	2003	HCRTR2, HCRT
24	Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies. (12677453)	Aronica E.... Gorter J.A.	2003	SCN1B
25	Clinicopathological correlation between brainstem gliosis using GFAP as a marker and sleep apnea in the sudden infant death syndrome. (14693386)	Sawaguchi T.... Kahn A.	2003	GFAP
26	Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain. (12968004)	Bruce-Keller A.J.... Nath A.	2003	TAT
27	Peripheral nerve exposure to HIV viral envelope protein gp120 induces neuropathic pain and spinal gliosis. (11311327)	Herzberg U.... Sagen J.	2001	ITIH4
28	Continuous interleukin-6 application in vivo via macroencapsulation of interleukin-6-expressing COS-7 cells induces massive gliosis. (11494414)	Tilgner J.... Kaltschmidt C.	2001	IL6
29	Schwannosis: role of gliosis and proteoglycan in huma n spinal cord injury. (11011818)	Bruce J.H.... Dietrich D.	2000	GFAP
30	Dementia, gliosis and expression of the small heat shock proteins hsp27 and alpha B-crystallin in Parkinson's disease. (10439447)	Renkawek K.... Bosman G.J.	1999	HSPB1, CRYAB
31	Tau gene mutation in familial progressive subcortical gliosis. (10202939)	Goedert M.... Gambetti P.	1999	MAPT
32	Dementia of frontal type and dementias with subcortic al gliosis. (9546290)	Mann D.M.	1998	RPS27A
33	Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement. (9630236)	Jones M.... Nath A.	1998	TAT
34	Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development. (8812062)	Corbin J.G.... Popko B.	1996	IFNG
35	Acute exposure to CNTF in vivo induces multiple compo nents of reactive gliosis. (8812159)	Levison S.W.... Wood T.L.	1996	CNTF
36	Periodic acid-Schiff (PAS)-positive deposits in brain following kainic acid-induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown. (7732785)	Bennett S.A.... Roberts D.C.	1995	FOS
37	Bilateral gliosis in unilaterally lesioned septohippocampal system: changes in GFAP immunoreactivity and content. (7563232)	JegliA8ski W.... Oderfeld-Nowak B.	1995	GFAP
38	Redox perturbations in cysteamine-stressed astroglia: implications for inclusion formation and gliosis in the aging brain. (8582655)	Manganaro F.... Schipper H.M.	1995	SOD2
39	Gliosis and axonal sprouting in the hippocampus of epileptic rats are associated with an increase of tenascin-C immunoreactivity. (7595669)	Niquet J.... Represa A.	1995	TNC
40	Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis. (8789663)	Miyazawa N.... Yamamoto Y.	1995	TSPO
41	A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury. (7597043)	Winter C.G.... Hirsh D.	1995	CNTF
42	Reactive gliosis and monoamine oxidase B. (7931234)	Ekblom J.... Aquilonius S.M.	1994	MAOB
43	Regional differences in reactive gliosis induced by substrate-bound beta-amyloid. (7821397)	HAPke A.... Silver J.	1994	APP
44	Immunocytochemical distribution of the brain glucose transporter (GLUT 1) in experimental gliosis. (7820675)	Rosenstein J.M.... Krum J.M.	1994	GFAP
45	Expression of small heat-shock protein hsp 27 in reactive gliosis in Alzheimer disease and other types of dementia. (8059604)	Renkawek K.... De Jong W.W.	1994	HSPB1
46	Gliosis in human brain: relationship to size but not other properties of astrocytes. (8422583)	da Cunha A.... Vitkovic L.	1993	GFAP
47	Biochemical correlates to cortical dysplasia, gliosis, and astrocytoma infiltration in human epileptogenic cortex. (8474570)	Hamberger A.... Haglid K.G.	1993	ENO2
48	A non-toxic method for the demonstration of gliosis. (1374794)	Manlow A.... Munoz D.G.	1992	GFAP
49	Quantitative aspects of reactive gliosis: a review. (1407275)	Norton W.T.... Brosnan C.F.	1992	GFAP
50	Comparison of immunocytochemical and Holzer's methods for detection of acute and chronic gliosis in human postmortem material. (1378333)	Stevens J.R.... Buchan G.C.	1992	GFAP

Genes related to gliosis according to GeneCards:

(show top 50)    (show all 70)

id	Symbol	Description	Score	GeneCards Section Context
1	GPSC	gliosis, familial progressive subcortical	11.1	Aliases & Descriptions
2	GFAP	glial fibrillary acidic protein	11.0	Publications
3	CNTF	ciliary neurotrophic factor	11.0	Publications
4	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
5	TAT	tyrosine aminotransferase	11.0	Publications
6	CRYAB	crystallin, alpha B	11.0	Publications
7	AQP4	aquaporin 4	11.0
8	GLUL	glutamate-ammonia ligase	11.0
9	PVALB	parvalbumin	11.0
10	DNTT	deoxynucleotidyltransferase, terminal	11.0
11	TNC	tenascin C	11.0	Publications
12	TSPO	translocator protein (18kDa)	11.0	Publications
13	PDGFA	platelet-derived growth factor alpha polypeptide	11.0
14	GALC	galactosylceramidase	11.0
15	MPZ	myelin protein zero	11.0
16	GLS	glutaminase	11.0
17	CA2	carbonic anhydrase II	11.0
18	CALB1	calbindin 1, 28kDa	11.0
19	CALB2	calbindin 2	11.0
20	CHAT	choline O-acetyltransferase	11.0
21	SYP	synaptophysin	11.0	Publications
22	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	11.0
23	NGFR	nerve growth factor receptor	11.0
24	BACE1	beta-site APP-cleaving enzyme 1	11.0
25	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0
26	MAPT	microtubule-associated protein tau	11.0	Publications
27	ITIH4	inter-alpha-trypsin inhibitor heavy chain family, member 4	11.0	Publications
28	HSPB1	heat shock 27kDa protein 1	11.0	Publications
29	S100B	S100 calcium binding protein B	11.0	Publications
30	RPS27A	ribosomal protein S27a	11.0	Publications
31	PRNP	prion protein	11.0	Publications
32	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.0
33	MAOB	monoamine oxidase B	11.0	Publications
34	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
35	GDNF	glial cell derived neurotrophic factor	11.0
36	GJA1	gap junction protein, alpha 1, 43kDa	11.0
37	GRM5	glutamate receptor, metabotropic 5	11.0
38	MBP	myelin basic protein	11.0
39	CP	ceruloplasmin (ferroxidase)	11.0
40	MAP2	microtubule-associated protein 2	11.0
41	NTRK2	neurotrophic tyrosine kinase, receptor, type 2	11.0
42	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
43	APP	amyloid beta (A4) precursor protein	11.0	Publications
44	ATXN1	ataxin 1	11.0
45	IL1A	interleukin 1, alpha	11.0
46	TH	tyrosine hydroxylase	11.0
47	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0
48	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0
49	NRG1	neuregulin 1	11.0
50	SCO2	SCO cytochrome oxidase deficient homolog 2 (yeast)	11.0

Pathways related to gliosis according to GeneDecks:

(show all 34)

id	Pathway	Score	Top Affiliating Genes
1	Glutamic acid signaling10	10.3	GRM5, GLUL, SLC1A2, SLC1A3
2	14-3-3 Induced Intracellular Signaling36	10.3	NRG1, MAPT, NTRK2, SNCA
3	Selected targets of GCR-alpha10	10.0	GLUL, MAP2, IL6, BACE1, CHAT
4	Metabolism of amino acids and derivatives38	10.0	GLUL, GCDH, GLS, TH, TAT
5	Alzheimers Disease Pathway36	9.8	MAPT, EGFR, NTRK2, APP
6	Prion diseases20	9.8	IL6, C5, PRNP, IL1A
7	Rho Family GTPases36	9.5	FOS, IL1A, HSPG2, TNC, NTRK2, NRG1
8	DHA Signaling36	9.2	NTRK2, EGFR, PDGFA, NGFR, MAPT, NRG1
9	JNK Pathway36	9.2	IL6, MAP2, TP53, NTRK2, NRG1, NGFR
10	Nuclear Receptor Activation by Vitamin-A36	9.1	NRG1, TAF1, IL6, NTRK2, EGFR, PDGFA
11	ERK5 Signaling36	9.0	FOS, IL6, NRG1, NGFR, PDGFA, EGFR
12	ERK Signaling36	9.0	IL1A, IL6, TNC, NRG1, PDGFA, EGFR
13	Neuroscience3	9.0	GFAP, ATXN1, APP, ENO2, SYP, NTRK2
14	CREB Pathway36	8.9	EGFR, PDGFA, NGFR, NRG1, NTRK2, IL6
15	NF-KappaB (p50-p65) Pathway36	8.9	NGFR, NRG1, IL1A, IL6, PDGFA, EGFR
16	Renin-Angiotensin Pathway36	8.9	NRG1, FOS, IL6, PDGFA, EGFR, NTRK2
17	PTEN Pathway36	8.9	TP53, TNC, EGFR, NGFR, NTRK2, NRG1
18	TGF-Beta Pathway36	8.9	IL1A, PDGFA, EGFR, IL6, NRG1, NGFR
19	Tec Kinases Signaling36	8.9	EGFR, NGFR, NRG1, NTRK2, IL6, FOS
20	Apoptotic Pathways in Synovial Fibroblasts36	8.8	IL6, EGFR, NGFR, NRG1, TP53, PDGFA
21	p53 Mediated Apoptosis36	8.8	PDGFA, IL6, TP53, NTRK2, NRG1, NGFR
22	Telomerase Components in Cell Signaling36	8.8	PDGFA, EGFR, IL6, NGFR, NRG1, NTRK2
23	Mitochondrial Apoptosis36	8.8	EGFR, NGFR, IL6, TP53, NTRK2, PDGFA
24	Cellular Apoptosis Pathway36	8.8	EGFR, PDGFA, NGFR, NRG1, NTRK2, IL6
25	Phospholipase-C Pathway36	8.7	NGFR, PDGFA, IL6, HSPG2, TNC, NTRK2
26	MAPK signaling pathway20	8.6	IL1A, MAPT, HSPB1, FOS, TP53, NTRK2
27	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.5	CYP19A1, FOS, IL1A, CA2, CALB1, IFNG
28	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.5	CALB1, IL1A, IL6, FOS, IFNG, CA2
29	p38 Signaling36	8.5	TP53, NTRK2, NRG1, NGFR, PDGFA, EGFR
30	Cytokine-cytokine receptor interaction20	8.5	PDGFA, NGFR, IFNG, IL6, CNTF, EGFR
31	Molecular Mechanisms of Cancer36	8.4	EGFR, FOS, IL6, NTRK2, NRG1, PDGFA
32	PKR Pathway36	8.3	TP53, PDGFA, IFNG, FOS
33	JAK-STAT Pathway36	8.1	NTRK2, NGFR, PDGFA, NRG1, IFNG, IL6
34	MAPK Signaling36	7.9	FOS, IL6, TNC, IL1A, NTRK2, NRG1

Compounds related to gliosis according to GeneDecks:

(show top 50)    (show all 257)

id	Compound	Score	Top Affiliating Genes
1	quinolinic acid32 18	10.7	CNTF, CHAT, ITIH4, CALB1, CALB2, GLS
2	ganglioside32	9.6	CNTF, MPZ, ITIH4, APP, MBP, ENO2
3	glucose32	9.5	CNTF, PARK2, S100B, HSPB1, CALB1, GLS
4	silver32	9.4	CHAT, MBP, ENO2, MAPT, MAP2, CALB1
5	ethanol32 34 9 18 9	13.2	CHAT, S100B, GRM5, MAP2, CALB2, GLUL
6	methionine32	9.2	CNTF, S100B, MPZ, FGF9, MAPT, MAP2
7	catecholamine32	9.2	CNTF, PARK2, CHAT, S100B, ENO2, MAOB
8	dbc-amp32	9.1	CHAT, S100B, FOS, ENO2, MAP2, HSPB1
9	methamphetamine32 9 9	11.0	CNTF, CHAT, MAP2, MAOB, CALB1, SNCA
10	5-hydroxytryptamine32	9.0	CHAT, IL1A, APP, ENO2, MAOB, HSPG2
11	progesterone32 42 9 18 9	12.9	CNTF, S100B, MPZ, MAP2, HSPB1, GJA1
12	cyclic amp32 18	9.8	CNTF, FOS, GRM5, MAP2, HSPG2, CA2
13	superoxide32 18	9.8	CNTF, PARK2, SCO2, BACE1, ENO2, MAP2
14	cocaine32 9 9	10.7	CNTF, CHAT, S100B, ITIH4, FOS, GRM5
15	choline32 9 18 9	11.7	CNTF, CHAT, S100B, APP, MBP, ENO2
16	arginine32	8.7	CNTF, S100B, MPZ, ITIH4, IL1A, APP
17	formaldehyde32 18	9.6	CHAT, S100B, IL1A, APP, MBP, ENO2
18	kainate32	8.6	CHAT, FOS, GRM5, MBP, MAPT, MAP2
19	h2o232	8.6	CNTF, PARK2, BACE1, ITIH4, MBP, MAPT
20	creatinine32	8.5	S100B, MPZ, IL1A, APP, MBP, ENO2
21	forskolin32 42 9 9	11.4	CNTF, CHAT, S100B, FOS, IL1A, MBP
22	oxygen32 18	9.4	PARK2, SCO2, BACE1, MAP2, MAOB, HSPB1
23	aspartate32	8.4	CHAT, BACE1, S100B, MPZ, ITIH4, GRM5
24	heparin32 9 18 9	11.4	BACE1, ITIH4, FGF9, APP, MBP, ENO2
25	adenylate32	8.1	CNTF, S100B, ITIH4, FOS, APP, MBP
26	glutamate32	8.0	CHAT, BACE1, MPZ, ITIH4, FOS, GRM5
27	lactate32	8.0	CHAT, S100B, ITIH4, IL6, MBP, ENO2
28	testosterone32 9 18 9	10.9	CNTF, PARK2, CHAT, S100B, ATXN1, IL1A
29	nitric oxide32 9 18 9	10.9	CNTF, PARK2, CHAT, S100B, GRM5, IL1A
30	alanine32	7.8	CNTF, PARK2, CHAT, BACE1, S100B, ITIH4
31	cysteine32	7.8	BACE1, S100B, MPZ, ITIH4, AQP4, MBP
32	gaba32 42	8.7	CNTF, CHAT, S100B, GRM5, IL1A, APP
33	dopamine32 9 18 9	10.7	CNTF, PARK2, CHAT, S100B, ITIH4, FOS
34	butyrate32	7.7	CHAT, FOS, APP, MAPT, IFNG, HSPB1
35	paraffin32	7.5	CHAT, S100B, ITIH4, MBP, ENO2, MAPT
36	calcium32 9 18 9	10.5	CNTF, PARK2, SCN1B, CHAT, S100B, FOS
37	glutamine32	7.4	PARK2, S100B, ATXN1, ITIH4, IL1A, APP
38	nmda32 42	8.4	PARK2, CHAT, ITIH4, FOS, GRM5, IL1A
39	indomethacin32 9 9	9.4	ITIH4, IL1A, IL6, MBP, ENO2, IFNG
40	acetylcholine32 9 18 9	10.2	CNTF, CHAT, BACE1, S100B, IL1A, APP
41	norepinephrine32 9 18 9	10.1	CNTF, CHAT, S100B, GRM5, IL1A, IL6
42	lipid32	7.1	PIK3C3, CNTF, PARK2, CHAT, BACE1, S100B
43	actinomycin d32	6.9	CNTF, ITIH4, FOS, IL1A, IL6, APP
44	dexamethasone32 42 34 9 9	10.2	CHAT, S100B, FOS, IL1A, IL6, AQP4
45	tyrosine32	5.7	CNTF, PARK2, CHAT, BACE1, S100B, MPZ
46	estrogen32	5.7	PARK2, CHAT, BACE1, S100B, FOS, FGF9
47	serine32	5.6	CNTF, PARK2, BACE1, S100B, MPZ, ITIH4
48	cycloheximide32	5.3	CNTF, CHAT, ITIH4, FOS, IL1A, IL6
49	retinoic acid32 42 18	6.8	CNTF, CHAT, S100B, FOS, IL1A, IL6
50	vegf32	4.6	CNTF, PARK2, S100B, FOS, FGF9, IL1A

Cellular components related to gliosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	9.7	CNTF, CHAT, APP, SNCA, MAPT, CALB1
2	neuronal cell body	GO:043025	9.4	CHAT, CNTF, MBP, SLC1A3, S100B, MAP2
3	cell surface	GO:009986	9.3	IL1A, PDGFA, NGFR, CRYAB, NTRK2, HSPB1
4	mitochondrion	GO:005739	8.4	GALC, CRYAB, PDHA1, SCO2, TAT, SNCA
5	cytosol	GO:005829	7.3	GLUL, GLS, CA2, CALB1, HSPB1, MAPT
6	extracellular space	GO:005615	6.6	CRP, PDGFA, EGFR, AGRP, CP, C5
7	extracellular region	GO:005576	6.4	SCN1B, CRP, NGFR, PDGFA, HCRT, CP

Biological processes related to gliosis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to wounding	GO:009611	10.4	PDGFA, NGFR, TNC, GFAP, SLC1A3
2	long-term synaptic potentiation	GO:060291	10.1	SNCA, NTRK2, GFAP
3	cellular copper ion homeostasis	GO:006878	10.1	APP, PRNP, SCO2
4	locomotory behavior	GO:007626	9.9	APP, CALB1, NRG1, TH
5	negative regulation of neuron apoptotic process	GO:043524	9.9	NTRK2, CNTF, PARK2, SNCA, SOD2, GDNF
6	anti-apoptosis	GO:006916	9.7	NGFR, GDNF, PRNP, RPS27A, CRYAB, SNCA
7	positive regulation of MAPK cascade	GO:043410	9.7	FGF9, CNTF, NTRK2, PDGFA, IL6
8	synaptic transmission	GO:007268	9.5	SLC1A3, HCRTR2, HCRT, GLS, MBP, GRM5
9	central nervous system development	GO:007417	9.1	NGFR, TP53, MBP, S100B, PARK2
10	response to drug	GO:042493	8.8	SLC1A3, CHAT, ENO2, MAOB, IFNG, CYP19A1
11	small molecule metabolic process	GO:044281	8.2	HSPG2, CA2, GLUL, CYP19A1, PDHA1, TH

Molecular functions related to gliosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chaperone binding	GO:051087	9.5	PARK2, TP53, PRNP, CP
2	receptor binding	GO:005102	9.2	GDNF, ADCYAP1, C5, AGRP, NRG1, TNC
3	copper ion binding	GO:005507	9.2	SNCA, PRNP, TP53, IL1A, SCO2, CP
4	growth factor activity	GO:008083	9.1	GDNF, CNTF, FGF9, IL6, NRG1, PDGFA
5	identical protein binding	GO:042802	8.6	EGFR, SNCA, TP53, GLUL, S100B, PRNP