Glomerulocystic Kidney Disease malady

MalaCards: Glomerulocystic Kidney Disease, also known as kidney diseases, is related to polycystic kidney disease and familial juvenile hyperuricaemic nephropathy. An important gene associated with Glomerulocystic Kidney Disease is MCKD2 (medullary cystic kidney disease 2 (autosomal dominant)), and among its related pathways are Selected targets of HNF1 and Maturity onset diabetes of the young. The drugs dopamine and albumin,human and the compounds nnmt and sulfonylurea have been mentioned in the context of this disorder. Affiliated tissues include kidney.

glomerulocystic kidney disease 7 kidney diseases 43

Diseases related to glomerulocystic kidney disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 204)

id	Related Disease	Score	Top Affiliating Genes
1	polycystic kidney disease	38.3	HNF1B, UMOD
2	familial juvenile hyperuricaemic nephropathy	32.5	MCKD2, UMOD
3	umod-associated kidney disease	31.8	MCKD2, UMOD
4	polycystic kidney disease, autosomal recessive	31.3	HNF1A, HNF1B
5	glomerulocystic kidney disease with hyperuricemia and isosthenuria	31.2	MCKD2, UMOD
6	insulin resistance	31.2	GCK, HNF1A, HNF1B
7	familial juvenile hyperuricemic nephropathy	29.6	UMOD, HNF1B
8	cystic kidney	29.5	UMOD, HNF1B
9	diabetes mellitus	28.8	GCK, UMOD, HNF1A, HNF1B
10	primary hyperoxaluria	28.1	GCK, UMOD, MCKD2, HNF1A, HNF1B
11	nephropathy	26.9	HNF1B, HNF1A, MCKD2, UMOD, GCK
12	renal cell carcinoma	26.9	UMOD, HNF1A, HNF1B
13	hyperglycemia	26.4	HNF1B, HNF1A, GCK
14	type 2 diabetes mellitus	26.3	GCK, HNF1A, HNF1B
15	thyroiditis	26.1	HNF1B, HNF1A, UMOD, GCK
16	vesicoureteral reflux	12.5	UMOD, HNF1B
17	gestational diabetes	12.4	GCK, HNF1A
18	neonatal diabetes mellitus	12.3	HNF1B, GCK
19	type 1 diabetes mellitus	12.1	GCK, HNF1A
20	glucose intolerance	12.0	GCK, HNF1A
21	diabetes mellitus, noninsulin-dependent	11.9	HNF1B, HNF1A, GCK
22	maturity-onset diabetes of the young	11.9	HNF1B, HNF1A, GCK
23	hyperinsulinism	11.7	GCK, HNF1B
24	twinning	11.7	HNF1B, UMOD, GCK
25	hyperuricemia	11.4	GCK, UMOD, MCKD2, HNF1B
26	hypertension	9.7
27	kidney disease	9.4
28	anemia	9.3
29	obesity	8.7
30	polycystic kidney disease 2	8.3
31	proteinuria	8.2
32	nephronophthisis	8.1
33	chronic kidney failure	7.8
34	aldosteronism	7.7
35	hyperparathyroidism	7.7
36	polycystic kidney disease, autosomal dominant	7.7
37	ren-related kidney disease	7.7
38	tuberous sclerosis	7.7
39	atherosclerosis	7.5
40	fibrosis	7.5
41	medullary cystic kidney disease 1	7.5
42	secondary hyperparathyroidism	7.5
43	alport syndrome	7.3
44	hepatitis	7.3
45	end stage renal failure	7.1
46	maturity-onset diabetes of the young, type 5	7.1
47	blastoma	7.1
48	hypothyroidism	7.1
49	hyperuricemic nephropathy	7.1
50	cystic fibrosis	6.8

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 albumin,human, albumin,human inj [va product], dopamine, dopamine hydrochloride

MalaCards organs/tissues related to glomerulocystic kidney disease:

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Articles related to glomerulocystic kidney disease:

id	Title	Authors	Year	Affiliating Genes
1	Hypoplastic glomerulocystic kidney disease and hepato blastoma: a potential association not caused by mutations in hepatocyte nuclear factor 1beta. (19564751)	Abdul-Rahman O.A.... Hattersley A.T.	2009	HNF1B
2	Hepatocyte nuclear factor-1beta frame-shift mutation in sporadic glomerulocystic kidney disease associated with agenesis of the corp us callosum. (20025686)	Yuan J.... Lv Y.	2009	HNF1B
3	A novel pattern of mutation in uromodulin disorders: autosomal dominant medullary cystic kidney disease type 2, familial juvenile hyperuricemic nephropathy, and autosomal dominant glomerulocystic kidney disease. (15983957)	Lens X.M.... Barrio-Lucia V.	2005	UMOD
4	De novo HNF-1 beta gene mutation in familial hypoplastic glomerulocystic kidney disease. (12478351)	Mache C.J.... Ring E.	2002	HNF1A
5	Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease. (11085914)	Bingham C.... Hattersley A.T.	2001	HNF1B
6	A case of glomerulocystic kidney disease associated with hypothyroidism in man. (2072050)	Katoh K.... Fukuchi S.	1991	GCK

Genes related to glomerulocystic kidney disease according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	MCKD2	medullary cystic kidney disease 2 (autosomal dominant)	11.0
2	UMOD	uromodulin	11.0	Publications
3	HNF1B	HNF1 homeobox B	11.0	Publications
4	GCK	glucokinase (hexokinase 4)	11.0	Publications
5	HNF1A	HNF1 homeobox A	11.0	Publications

Pathways related to glomerulocystic kidney disease according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of HNF110	8.8	UMOD, HNF1A, HNF1B
2	Maturity onset diabetes of the young20	8.4	GCK, HNF1A, HNF1B
3	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	8.2	GCK, HNF1A, HNF1B

Compounds related to glomerulocystic kidney disease according to GeneDecks:

(show all 12)

id	Compound	Score	Top Affiliating Genes
1	nnmt32	9.6	HNF1B, HNF1A
2	sulfonylurea32	9.4	HNF1A, GCK
3	uric acid32 18	10.3	UMOD, HNF1B
4	tolbutamide32 34 9 9	12.3	GCK, HNF1A
5	phosphoenolpyruvate32 9 9	11.3	HNF1A, GCK
6	c-peptide32	9.2	HNF1A, GCK
7	citrate32	9.1	UMOD, GCK
8	potassium32 9 18 9	11.8	GCK, UMOD, HNF1A
9	creatinine32	8.7	HNF1A, GCK, UMOD
10	cholesterol32 9 18 9	11.4	HNF1B, HNF1A, GCK
11	glucose32	8.2	HNF1B, HNF1A, UMOD, GCK
12	oligonucleotide32	8.2	HNF1B, HNF1A, GCK

Biological processes related to glomerulocystic kidney disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of pronephros size	GO:035565	9.4	HNF1B, HNF1A
2	positive regulation of transcription initiation from RNA polymerase II promoter	GO:060261	9.3	HNF1A, HNF1B
3	insulin secretion	GO:030073	9.2	HNF1B, HNF1A
4	glucose homeostasis	GO:042593	9.1	GCK, HNF1A
5	endocrine pancreas development	GO:031018	8.7	HNF1B, GCK