MCID: GLM007
MIFTS: 59

Glomerulonephritis malady

Rare diseases, Nephrological diseases categories

Aliases & Classifications for Glomerulonephritis

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Glomerulonephritis, Aliases & Descriptions:

Name: Glomerulonephritis 30 9 41 11 43 60
 
Bright's Disease 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:2921
MeSH33 D005921
SNOMED-CT55 197648001, 36171008
NCIt38 C26784

Summaries for Glomerulonephritis

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NIH Rare Diseases:41 Glomerulonephritis is a type of kidney disease in which there is inflammation of the glomeruli, the tiny filters that remove excess waste and fluids from the blood. it may be acute or chronic (coming on gradually), and may occur on its own (primary) or be caused by another condition (secondary). signs and symptoms may depend on the type and cause of the condition and may include blood in the urine; foamy urine; swelling of the face, eyes, or other body parts; abdominal pain; high blood pressure; fatigue; and/or other symptoms. if the condition is severe or prolonged, the kidneys can become damaged. it may be caused by a variety of infections and diseases, and sometimes the cause is unknown. treatment depends on the cause, type and severity of the condition. last updated: 7/17/2012

MalaCards based summary: Glomerulonephritis, also known as bright's disease, is related to proliferative glomerulonephritis and acute poststreptococcal glomerulonephritis. An important gene associated with Glomerulonephritis is CFHR5 (complement factor H-related 5), and among its related pathways are Prion diseases and LDL Oxidation in Atherogenesis. The compounds tositumomab and adalimumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and neutrophil, and related mouse phenotypes are tumorigenesis and normal.

Disease Ontology:9 A nephritis that causes inflammation of the glomeruli located in kidney.

Wikipedia:63 Glomerulonephritis, also known as glomerular nephritis, is a term used to refer to several kidney... more...

Related Diseases for Glomerulonephritis

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Diseases in the Glomerulonephritis family:

Subacute Glomerulonephritis

Diseases related to Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 494)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative glomerulonephritis32.3CCL2, CD79A
2acute poststreptococcal glomerulonephritis31.9CFP, CD79A
3mesangial proliferative glomerulonephritis31.8CD79A, MBL2
4hepatitis31.6CR1, ALB, TGFB1
5systemic lupus erythematosus31.6CR1
6rapidly progressive glomerulonephritis31.6ICAM1, PRTN3, MPO
7membranoproliferative glomerulonephritis31.6CFP, CFH, C3, MBL2, CD79A
8nephrotic syndrome31.5CD79A, ALB, CFI
9endocarditis31.3PRTN3
10hepatitis c31.2TGFB1, CCR5, CR1
11pyelonephritis31.2CD79A
12hepatitis b31.2CD79A, MBL2, CR1, ALB
13lupus erythematosus31.0CD79A, C3, CFP, C1QA
14dense deposit disease/membranoproliferative glomerulonephritis type ii30.9CFH, CFHR5
15thyroiditis30.9MBL2, CD79A
16hemolytic-uremic syndrome30.9CFH, CFI
17lipoid nephrosis30.9CCL2, ALB, CD79A
18syphilis30.8CCR5, CD79A
19henoch-schoenlein purpura30.7MPO, ICAM1, CD79A
20churg-strauss syndrome30.7MPO, PRTN3
21c1q deficiency30.7C1QA, C1QC, C1QB
22subacute bacterial endocarditis30.7PRTN3
23nephrosclerosis30.6TGFB1, AGTR1
24focal segmental glomerulosclerosis30.6ALB, CD79A, AGTR1
25thrombocytopenia30.6CFH, ALB, CD79A
26arteriolosclerosis30.5CD79A
27q fever30.5CD79A
28liver cirrhosis30.5TGFB1, ALB, CR1
29agammaglobulinemia30.5CD79A, CFP
30tuberculosis30.4C3, ALB, CR1, MBL2, CD79A
31kidney disease30.4AGTR1, CCL2, ICAM1, TGFB1
32membranous glomerulonephritis, antenatal30.4CCL2, CCR5, ALB, CR1, CD79A
33meningococcal meningitis30.4CFP, MBL2
34bronchitis30.4CD79A
35malaria30.3CFP, ICAM1, ALB, CR1
36renal fibrosis30.3AGTR1, CCL2, TGFB1
37bronchiectasis30.3MPO, MBL2, CD79A
38systemic mastocytosis30.3MPO, CCL2
39pancreatitis30.3ALB, ICAM1, TGFB1, MPO
40graves' disease30.2MPO, ICAM1, CCR5
41glomerulosclerosis30.2CFH, TGFB1, CCL2, ALB, CR1, CD79A
42primary biliary cirrhosis30.2PRTN3, ALB, MBL2, CD79A
43portal hypertension30.2ALB, AGTR1
44complement deficiency30.2CFP, C3, CR1, MBL2
45influenza30.1CCR5, CR1, MBL2, CD79A
46meningitis30.1CFP, CFI, ALB, MBL2, CD79A
47periodontal disease30.1MPO, ICAM1, CD79A
48liver disease30.1TGFB1, ICAM1, ALB, CD79A
49pulmonary sarcoidosis30.1ICAM1, CCL2, CCR5
50reactive arthritis30.1CD79A, CR1, PRTN3

Graphical network of the top 20 diseases related to Glomerulonephritis:



Diseases related to glomerulonephritis

Symptoms for Glomerulonephritis

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Drugs & Therapeutics for Glomerulonephritis

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Drug clinical trials:

Search ClinicalTrials for Glomerulonephritis

Search NIH Clinical Center for Glomerulonephritis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Glomerulonephritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Glomerulonephritis:
Mesenchymal stromal cells for glomerulonephritis
Embryonic/Adult Cultured Cells Related to Glomerulonephritis:
Bone marrow-derived mesenchymal stromal cells, PMID: 22172807

Genetic Tests for Glomerulonephritis

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Anatomical Context for Glomerulonephritis

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MalaCards organs/tissues related to Glomerulonephritis:

31
Kidney, Neutrophil, Eye, Liver, T cells, Endothelial, Bone, Monocytes, B cells, Bone marrow, Testes, Thyroid, Lung, Lymph node, Spleen, Skin, Myeloid, Smooth muscle, Heart, Brain, Colon, Prostate, Cortex, Pancreas, Breast, Ovary, Pons

FMA organs/tissues related to Glomerulonephritis:

14
Kidney

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Glomerulonephritis:
id TissueAnatomical CompartmentCell Relevance
1 KidneyGlomerulus  Affected by disease

Animal Models for Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Glomerulonephritis:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4ALB, CCR5, CCL2, ICAM1, TGFB1
2MP:00028738.0C1QA, CFP, CFH, CCL2, C3, ALB
3MP:00053817.6TGFB1, ICAM1, CCL2, CCR5, C3, ALB
4MP:00053917.6CFH, TGFB1, ICAM1, CCL2, CCR5, C3
5MP:00053697.4MPO, TGFB1, ICAM1, CCL2, CCR5, C3
6MP:00053677.2C1QA, CFH, CFI, TGFB1, C3, ALB
7MP:00053847.0C1QA, TGFB1, ICAM1, CCL2, CCR5, C3
8MP:00036316.8C1QA, CFH, TGFB1, ICAM1, CCL2, CCR5
9MP:00053856.7CFP, CFH, MPO, TGFB1, ICAM1, CCL2
10MP:00053976.3CFH, MPO, TGFB1, PRTN3, ICAM1, CCL2
11MP:00107686.1C1QA, CFP, CFH, MPO, TGFB1, ICAM1
12MP:00053765.5TGFB1, MPO, CFI, CFH, CFP, ICAM1
13MP:00053875.3AGTR1, C1QA, CFP, CFH, MPO, TGFB1

Publications for Glomerulonephritis

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Articles related to Glomerulonephritis:

(show top 50)    (show all 3602)
idTitleAuthorsYear
1
Study on Hyperuricemia in HBV-Associated Glomerulonephritis. (24343739)
2014
2
Management of crescentic glomerulonephritis: what are the recent advances? (23689584)
2013
3
Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. (24215355)
2013
4
What is the significance of HLA-DR antigen expression in the extraglomerular mesangium in glomerulonephritis? (22890012)
2012
5
Rapidly progressive glomerulonephritis associated with PR3-ANCA positive subacute bacterial endocarditis. (22989831)
2012
6
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
7
Involvement of the intrarenal renin-angiotensin system in experimental models of glomerulonephritis. (22811597)
2012
8
New insights into membranous glomerulonephritis: from bench to bedside. (21803731)
2011
9
Interleukin-18, transforming growth factor-I^, and vascular endothelial growth factor gene polymorphisms and susceptibility to primary glomerulonephritis. (20545903)
2010
10
Effects of simvastatin therapy on the lipid blood spectrum and nitric oxide in patients with chronic glomerulonephritis]. (19663018)
2008
11
Uric acid excretion and dopamine-induced glomerular filtration response in patients with IgA glomerulonephritis. (18063857)
2008
12
Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. (16482158)
2006
13
CD20-positive infiltrates in human membranous glomerulonephritis. (16013025)
2005
14
A rare form of crescentic glomerulonephritis with mixed immunopathological features. (15841695)
2004
15
IgA-associated glomerulonephritis with membranoproliferative glomerulonephritis-like pattern in two children. (14712358)
2003
16
Arterial hypertension in glomerulonephritis]. (14974362)
2003
17
A protective role for endothelial nitric oxide synthase in glomerulonephritis. (11849432)
2002
18
Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. (12105242)
2002
19
p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis. (12032188)
2002
20
Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomerulonephritis. (11981066)
2002
21
Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis. (11796821)
2002
22
Bucillamine induces membranous glomerulonephritis. (11920335)
2002
23
Acute poststreptococcal glomerulonephritis: public health implications of recent clusters in New South Wales and epidemiology of hospital admissions. (11467793)
2001
24
Acute glomerulonephritis with group A streptococcal vulvovaginitis. (11156071)
2000
25
Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis. (10878552)
2000
26
Decreasing hypocomplementemia and membranoproliferative glomerulonephritis in Japan. (10955929)
2000
27
Quantification of changes in transforming growth factor-beta1 gene expression in experimental crescentic glomerulonephritis. (9034137)
1997
28
Glomerular expression of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in patients with various forms of glomerulonephritis. (8804363)
1996
29
Hepatitis C virus associated membranous glomerulonephritis. (8556829)
1995
30
Present possibilities of treatment of primary chronic glomerulonephritis]. (8073642)
1994
31
The detection of modified forms of serum albumin in glomerulonephritis patients by spectrofluorometry]. (7940359)
1994
32
Glomerulonephritis associated with inflammatory demyelinating polyradiculoneuropathy: a case report and review of the literature. (8502319)
1993
33
Heymann nephritis revisited--new insights into the pathogenesis of experimental membranous glomerulonephritis. (8252799)
1993
34
Rapidly progressive glomerulonephritis and pulmonary tuberculosis. (2020362)
1991
35
Prognostic factors in mesangial IgA glomerulonephritis: an extensive study with univariate and multivariate analyses. (2063844)
1991
36
Glomerular deposition of C4 cleavage fragment (C4d) and C4-binding protein in idiopathic membranous glomerulonephritis. (2644563)
1989
37
Factors influencing the development of hypertensive encephalopathy in acute glomerulonephritis. (3252963)
1988-1989
38
Differences between membranoproliferative glomerulonephritis types I and III in clinical presentation, glomerular morphology, and complement perturbation. (3826060)
1987
39
Membranous glomerulonephritis associated with chronic progressive demyelinating neuropathy. (3027615)
1987
40
Rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis during treatment with high-dosage D-penicillamine. (4014326)
1985
41
Failure of affinity maturation leads to increased susceptibility to immune complex glomerulonephritis. (6234231)
1984
42
Plasmapheresis treatment of idiopathic rapidly progressive glomerulonephritis. (6642730)
1983
43
Hepatitis B e antigen-mediated membranous glomerulonephritis. Correlation of ultrastructural changes with HBeAg in the serum and glomeruli. (7464047)
1981
44
Plasmapheresis for rapidly progressive glomerulonephritis: the mystique of dramatic intervention. (7431575)
1980
45
Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. (7400310)
1980
46
Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins. (314784)
1979
47
IgA glomerulonephritis. Mesangial IgA deposition without systemic signs (Berger's disease). (536183)
1979
48
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
49
A specific antigen and antibody in acute poststreptococcal glomerulonephritis. (4911994)
1969
50
CLINICOPATHOLOGIC conference subacute glomerulonephritis. (13062339)
1953

Variations for Glomerulonephritis

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Expression for genes affiliated with Glomerulonephritis

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Search GEO for disease gene expression data for Glomerulonephritis.

Pathways for genes affiliated with Glomerulonephritis

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Pathways related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8C1QA, C1QC, C1QB
29.6CCL2, ICAM1, MPO
3
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.5MPO, CCL2, AGTR1
49.3CCL2, ICAM1, TGFB1
5
Show member pathways
thioredoxin pathway36
9.3MPO, ICAM1, CCL2, ALB
69.1TGFB1, ICAM1, CCL2, CR1
79.1C1QB, TGFB1, ICAM1, CCL2
89.0MBL2, C3, MPO
9
Show member pathways
9.0C3, C1QA, C1QC, C1QB
109.0C1QB, C1QC, C1QA, C3
11
Show member pathways
8.7CFP, ICAM1, CCL2, C3
12
Show member pathways
8.3TGFB1, CCR5, C3, CR1
13
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.2C1QB, C1QC, C1QA, TGFB1, CCL2, C3
14
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
7.8C1QA, C1QC, C1QB, CFH, CFI, C3
15
Show member pathways
7.8C1QB, C1QC, C1QA, CFH, CFI, C3
167.7C1QB, MBL2, C3, ICAM1, CFI, CFH
17
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
7.5MBL2, CR1, C3, CFI, CFH, CFP

Compounds for genes affiliated with Glomerulonephritis

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Compounds related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1tositumomab49 1211.0C1QA, C1QC, C1QB
2adalimumab43 49 1211.9C1QC, C1QB, CD79A, C1QA
3ibritumomab49 1210.9C1QA, C1QB, C1QC
4efalizumab43 1210.9C1QB, C1QC, ICAM1, C1QA
5natalizumab43 1210.8C1QB, C1QC, ICAM1, C1QA
6bevacizumab49 1210.8C1QC, C1QA, C1QB
7alefacept43 1210.7C1QB, C1QC, C1QA
8sulfasalazine28 43 49 1212.7MPO, CD79A, ICAM1, CCL2
9mannan439.6CD79A, MBL2, CR1, CFP
10polymyxin b439.6CR1, MBL2, CCL2, ICAM1
118-isoprostane439.5MPO, ICAM1, CCL2, AGTR1
12n-formylmethionyl-leucylphenylalanine439.4PRTN3, MPO, ICAM1, CR1
13prednisolone43 28 1211.4CD79A, MBL2, ALB, CR1, MPO
14vitamin b12439.4MPO, CCL2, ALB, CD79A
15ramipril43 1210.3CD79A, AGTR1, ALB, TGFB1
16diphenyleneiodonium439.3MPO, ICAM1, CCL2, TGFB1
17cardiolipin43 1210.3CFH, CD79A, MBL2, PRTN3
18candesartan43 49 28 1212.3ALB, CCL2, TGFB1, AGTR1
19polyethylene glycol439.1CD79A, MPO, ALB, ICAM1, TGFB1
20fmlp439.1ICAM1, CCL2, CR1, MPO, PRTN3
21methacholine43 49 1211.1MPO, TGFB1, AGTR1, CD79A, ICAM1
22thyroxine43 2410.1MBL2, ALB, CFI, TGFB1, CD79A
23dextran sulfate439.0CFP, MPO, ICAM1, CCR5, ALB
24anaphylatoxin439.0CR1, C3, CCL2, MPO, CFP
25rituximab43 49 1210.9C1QC, C1QA, TGFB1, C1QB, PRTN3, CD79A
26tacrolimus43 49 1210.8CD79A, AGTR1, ALB, CFH, TGFB1
27formaldehyde43 249.8CR1, MPO, TGFB1, PRTN3, CCL2, CD79A
28paraffin438.8CD79A, MBL2, MPO, CR1, TGFB1, CCL2
29hyaluronic acid43 249.6PRTN3, ICAM1, ALB, CD79A, TGFB1, CFH
30neopterin438.3C3, ICAM1, MBL2, CD79A
31superoxide43 249.3CFP, MBL2, CR1, AGTR1, CCL2, PRTN3
32pge2438.3MPO, ICAM1, CCL2, CCR5, CD79A, TGFB1
33histamine43 28 2410.3MPO, TGFB1, ICAM1, CCL2, CCR5, ALB
34mannose438.2CD79A, CFP, CCR5, C3, CR1, MBL2
35cyclosporin a43 28 5910.2CCR5, AGTR1, CD79A, CFH, TGFB1, ICAM1
36vegf438.1TGFB1, CD79A, AGTR1, MBL2, CCL2, ICAM1
37lactate438.0CD79A, MPO, ALB, ICAM1, TGFB1, C3
38vitamin d437.8CCR5, ALB, MBL2, CCL2, TGFB1, CD79A
39retinoic acid43 248.6CD79A, CR1, CCR5, ICAM1, PRTN3, TGFB1
40fibrinogen437.5CD79A, MBL2, AGTR1, ALB, C3, CCL2
41oxygen43 248.5MBL2, C3, MPO, CCL2, AGTR1, PRTN3
42cholesterol43 28 24 1210.4AGTR1, ALB, C3, CCR5, CCL2, CFI
43creatinine437.4TGFB1, CD79A, AGTR1, MPO, CCL2, C3
44cysteine437.2CD79A, MBL2, AGTR1, ALB, C3, CCR5
45estrogen437.0C3, CCR5, TGFB1, MBL2, CD79A, CFI
46calcium43 49 24 129.9CFI, C1QC, C1QA, ALB, PRTN3, CCL2
47heparin43 28 24 129.9CFP, CR1, CD79A, AGTR1, C3, CCR5
48dexamethasone43 49 28 129.9CFH, TGFB1, ICAM1, CCL2, CCR5, AGTR1
49polysaccharide436.8C3, CD79A, MBL2, CFP, CFH, TGFB1
50serine436.4AGTR1, C3, CCR5, PRTN3, TGFB1, MPO

GO Terms for genes affiliated with Glomerulonephritis

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Cellular components related to Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1complement component C1 complexGO:00056029.9C1QA, C1QB
2collagenGO:00055819.4C1QB, C1QC, C1QA, MBL2
3cell surfaceGO:00099868.7MBL2, CR1, CCR5, TGFB1
4blood microparticleGO:00725628.1C1QB, C1QC, CFH, TGFB1, C3, ALB
5extracellular vesicular exosomeGO:00700627.5CFI, MPO, PRTN3, ICAM1, C3, ALB
6extracellular regionGO:00055766.5MBL2, C1QB, C1QC, C1QA, CFP, CFH
7extracellular spaceGO:00056156.5CFI, CFH, CFP, C1QC, MPO, TGFB1

Biological processes related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle remodelingGO:00343749.9MPO, AGTR1
2response to amino acidGO:00432009.8CCL2, ICAM1
3negative regulation of growth of symbiont in hostGO:00441309.8MBL2, MPO
4negative regulation of phagocytosisGO:00507659.7TGFB1, PRTN3
5positive regulation of cellular protein metabolic processGO:00322709.6AGTR1, TGFB1
6response to cholesterolGO:00707239.6TGFB1, CCR5
7cellular response to lipopolysaccharideGO:00712229.5CCR5, CCL2, ICAM1
8agingGO:00075689.5MPO, TGFB1, CCL2
9MAPK cascadeGO:00001659.3TGFB1, CCL2, CCR5
10complement activation, alternative pathwayGO:00069579.1C3, CFHR5, CFH, CFP
11positive regulation vascular endothelial growth factor productionGO:00105759.0C3, TGFB1
12positive regulation of phagocytosisGO:00507668.9MBL2, C3
13regulation of complement activationGO:00304498.9CFP, CFH, CFI, C3, CR1
14immune responseGO:00069558.6C3, CCR5, CFP, C1QC
15G-protein coupled receptor signaling pathwayGO:00071868.5AGTR1, C3, CCR5, CCL2
16complement activation, classical pathwayGO:00069588.5C1QB, C1QC, C1QA, CFI, C3, CR1
17inflammatory responseGO:00069548.4TGFB1, CCL2, CCR5, C3
18complement activationGO:00069568.2MBL2, C1QB, C1QC, C1QA, CFP, CFH
19innate immune responseGO:00450877.8C1QB, C1QC, C1QA, CFP, CFH, CFI

Molecular functions related to Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.6CCL2, MPO, CFH

Products for genes affiliated with Glomerulonephritis

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Sources for Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet