MCID: GLM007
MIFTS: 66

Glomerulonephritis malady

Summaries for Glomerulonephritis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Glomerulonephritis is a type of kidney disease in which there is inflammation of the glomeruli, the tiny filters that remove excess waste and fluids from the blood. it may be acute or chronic (coming on gradually), and may occur on its own (primary) or be caused by another condition (secondary). signs and symptoms may depend on the type and cause of the condition and may include blood in the urine; foamy urine; swelling of the face, eyes, or other body parts; abdominal pain; high blood pressure; fatigue; and/or other symptoms. if the condition is severe or prolonged, the kidneys can become damaged. it may be caused by a variety of infections and diseases, and sometimes the cause is unknown. treatment depends on the cause, type and severity of the condition. last updated: 7/17/2012

MalaCards: Glomerulonephritis is related to membranous glomerulonephritis and membranoproliferative glomerulonephritis. An important gene associated with Glomerulonephritis is CFHR5 (complement factor H-related 5), and among its related pathways are Immune response Lectin induced complement pathway and Immune System. The compounds calcium and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and eye, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A nephritis that causes inflammation of the glomeruli located in kidney.

Wikipedia:63 Glomerulonephritis, also known as glomerular nephritis, is a term used to refer to several renal... more...

Aliases & Classifications for Glomerulonephritis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

glomerulonephritis 8 42 10 44 30 60


External Ids:

Disease Ontology8 DOID:2921
MeSH34 D005921
SNOMED-CT56 197648001, 36171008
NCIt39 C26784

Related Diseases for Glomerulonephritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glomerulonephritis family:

Subacute Glomerulonephritis

Diseases related to Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 510)
idRelated DiseaseScoreTop Affiliating Genes
1membranous glomerulonephritis31.6CCR5, CCL2, CR1, CD79A, ALB
2membranoproliferative glomerulonephritis31.6MBL2, CD79A, CFH, CFP
3proliferative glomerulonephritis31.5CD79A, CCL2
4rapidly progressive glomerulonephritis31.4PRTN3, ICAM1, MPO
5iga glomerulonephritis31.3ALB, CFP, CFH, CD79A, AGTR1, PRTN3
6hepatitis31.2TGFB1, ALB, CR1
7mesangial proliferative glomerulonephritis31.2CD79A, MBL2
8acute poststreptococcal glomerulonephritis31.2CFP, CD79A
9hepatitis c31.0CCR5, CR1, TGFB1
10nephrotic syndrome30.9CD79A, CFI, ALB
11vasculitis30.9ALB, CFI, CD79A, PRTN3, MPO, MBL2
12proteinuria30.9TGFB1, ALB, CFP, CD79A, AGTR1, PRTN3
13hepatitis b30.9TGFB1, ALB, CR1, MBL2, CCR5
14arthritis30.8TGFB1, ALB, AGTR1, PRTN3, MPO, CR1
15lupus erythematosus30.7C1QA, CD79A, CFP
16endocarditis30.7PRTN3
17systemic lupus erythematosus30.7CR1
18cryoglobulinemia30.7CD79A
19rheumatoid arthritis30.7CFI, CD79A, PRTN3, MPO, ITGAL, CR1
20hypertension30.7CCL2, ICAM1, AGTR1, CD79A, ALB, TGFB1
21purpura30.7CD79A
22complement deficiency30.5MBL2, CR1, CFP
23leukemia30.5ICAM1, MBL2, SCGB1A1, CR1, ITGAL, MPO
24amyloidosis30.5ALB, CD79A
25diabetes mellitus30.5CCL2, ICAM1, AGTR1, CD79A, CFP, ALB
26tuberculosis30.4MBL2, CR1, ITGAL, CD79A, ALB
27myeloma30.4ICAM1, ITGAL, CD79A, ALB
28pneumonia30.4TGFB1, CD79A, MPO, CR1, SCGB1A1, MBL2
29diabetic nephropathy30.4CCL2, AGTR1, ALB, TGFB1
30wegener's granulomatosis30.3PRTN3, MPO, CCR5
31pyelonephritis30.3CD79A
32lipoid nephrosis30.3CCL2, CD79A, ALB
33rheumatic fever30.3MBL2
34sarcoidosis30.3SCGB1A1, ICAM1, CCL2, CCR5, CR1
35primary biliary cirrhosis30.2MBL2, ITGAL, PRTN3, CD79A, ALB
36focal segmental glomerulosclerosis30.2ALB, CD79A, AGTR1
37thyroiditis30.2CD79A, MBL2
38connective tissue disease30.2CCL2, ICAM1, MPO, PRTN3, CD79A, CFP
39hemolytic-uremic syndrome30.2CFI, CFH
40nephrosclerosis30.2TGFB1, AGTR1
41viral hepatitis30.2ITGAL
42complement factor h deficiency30.2CFH
43antiphospholipid syndrome30.2CFH, CD79A
44liver cirrhosis30.2CR1, ALB, TGFB1
45ankylosing spondylitis30.1CD79A
46pancreatitis30.1ICAM1, MPO, ALB, TGFB1
47neuropathy30.1ALB, CD79A
48berger disease30.1SCGB1A1
49subacute bacterial endocarditis30.1PRTN3
50autoimmune hemolytic anemia30.1CD79A

Graphical network of the top 20 diseases related to Glomerulonephritis:



Diseases related to glomerulonephritis

Clinical Features for Glomerulonephritis

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Drugs & Therapeutics for Glomerulonephritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Glomerulonephritis

Search NIH Clinical Center for Glomerulonephritis

Search CenterWatch for Glomerulonephritis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Glomerulonephritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Glomerulonephritis:
Mesenchymal stromal cells for glomerulonephritis
Embryonic/Adult Cultured Cells Related to Glomerulonephritis:
Bone marrow-derived mesenchymal stromal cells, PMID: 22172807

Genetic Tests for Glomerulonephritis

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Anatomical Context for Glomerulonephritis

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Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Glomerulonephritis:

32
Kidney, Eye, Liver, T cells, Endothelial, Monocytes, Bone, B cells, Testes, Thyroid, Bone marrow, Lung, Skin, Lymph node, Spleen, Myeloid, Smooth muscle, Heart, Brain, Prostate, Colon, Ovary, Breast, Pancreas, Pons, Cortex

FMA organs/tissues related to Glomerulonephritis:

14
Kidney

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Glomerulonephritis:
id TissueAnatomical CompartmentCell Relevance
1 KidneyGlomerulus  Affected by disease

Animal Models for Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1TGFB1, C1QA, CCR5, CCL2, ICAM1, MBL2
2MP:000537612.1ITGAL, SCGB1A1, MBL2, ICAM1, CCL2, CCR5
3MP:001076811.3C1QA, CCR5, CCL2, ICAM1, SCGB1A1, MPO
4MP:000539711.3CCR5, CCL2, ICAM1, MBL2, ITGAL, MPO
5MP:000200611.2CCR5, CCL2, ICAM1, SCGB1A1, ITGAL, ALB
6MP:000538511.1CCL2, MPO, AGTR1, CFH, CFP, CCR5
7MP:000536711.1C1QA, SCGB1A1, AGTR1, CFI, CFH

Publications for Glomerulonephritis

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Sources:
50PubMed
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Articles related to Glomerulonephritis:

(show top 50)    (show all 3507)
idTitleAuthorsYear
1
Rapidly progressive glomerulonephritis due to anti-glomerular basement membrane disease accompanied by IgA nephropathy: a case report. (23149250)
2014
2
Monoclonal gammopathy-associated pauci-immune extracapillary-proliferative glomerulonephritis successfully treated with bortezomib. (24282629)
2013
3
Immune complex binding Streptococcus pyogenes type M12/emm12 in experimental glomerulonephritis. (23788594)
2013
4
Post-streptococcal glomerulonephritis is a strong risk factor for chronic kidney disease in later life. (22297679)
2012
5
Induction of IgA deposits and glomerulonephritis by IgA rheumatoid factor. (22323642)
2012
6
Glomerulonephritis therapy: is there a role for green tea? (21878951)
2011
7
A paraneoplastic membranoproliferative glomerulonephritis with isolated C3 deposits associated with hairy cell leukaemia. (20335271)
2010
8
Toll-like receptor 4 stimulation triggers crescentic glomerulonephritis by multiple mechanisms including a direct effect on renal cells. (20566738)
2010
9
Histopathological manifestations of membranoproliferative glomerulonephritis and glomerular expression of plasmalemmal vesicle-associated protein-1 in a patient with polycythemia vera. (20979949)
2010
10
Crescentic glomerulonephritis with ribbon-like immunofluorescence pattern. (19121555)
2009
11
Cryptococcosis associated with crescentic glomerulonephritis. (18253761)
2008
12
Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. (17259999)
2007
13
Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat. (16467449)
2006
14
Quiz page. Proliferative glomerulonephritis. (12621658)
2003
15
Concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia. (14586676)
2003
16
Cortical blindness in a boy with acute glomerulonephritis. (12684614)
2003
17
Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. (12091909)
2002
18
Circulating antibodies recognising oxidatively-modified low-density lipoproteins in patients with IgA nephropathy, membranous glomerulonephritis and focal glomerulosclerosis. (12243363)
2002
19
Expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in human crescentic glomerulonephritis. (12147094)
2002
20
Glomerulonephritis after methicillin-resistant Staphylococcus aureus infection resulting in end-stage renal failure. (11393416)
2001
21
AL-amyloidosis of the kidney initially presenting as minimal change glomerulonephritis. (10977797)
2000
22
Heparin-binding EGF-like growth factor is expressed by mesangial cells and is involved in mesangial proliferation in glomerulonephritis. (10547607)
1999
23
Glomerular enlargement in the progression of mesangial proliferative glomerulonephritis. (9543595)
1998
24
Methylprednisolone pulse therapy in two clinical types of crescentic glomerulonephritis. (9711884)
1998
25
Proteinase-3-antineutrophil cytoplasmic antibody (PR3-ANCA) positive crescentic glomerulonephritis in a patient with Down's syndrome and infectious endocarditis. (9719187)
1998
26
Simple urine testing could avoid delay in the diagnosis of rapidly progressive glomerulonephritis. (9497951)
1997
27
Role of cytokines and growth factors in glomerulonephritis: a chance for future therapeutic intervention. (8856243)
1996
28
Rapidly progressive glomerulonephritis after immunotherapy for cancer. (7787140)
1995
29
Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis. (7847352)
1995
30
Henoch-SchAPnlein purpura with rapidly progressive glomerulonephritis and fatal intraperitoneal hemorrhage in an adult. (8107311)
1994
31
Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders. (7838242)
1994
32
Hepatitis B 's' and 'e' antigen carriage in childhood nephrotic syndrome predicts membranous glomerulonephritis. (7681650)
1993
33
Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis. (8475090)
1993
34
Crescentic glomerulonephritis associated with puerperal sepsis. (1816208)
1991
35
Ultrastructural studies in passive in situ immune complex glomerulonephritis. A rat model for membranous glomerulonephritis. (2482573)
1989
36
Glomerular procoagulant activity in human proliferative glomerulonephritis. (3335629)
1988
37
The cell biology of Heymann nephritis: a model of human membranous glomerulonephritis. (3300288)
1987
38
Hepatitis B-associated membranous glomerulonephritis treated with adenine arabinoside monophosphate. (2426174)
1986
39
Membranoproliferative glomerulonephritis with IgA deposits in patients with alcoholic cirrhosis. (3615024)
1986
40
Glomerulonephritis in lambs with coccidiosis. (3800808)
1986
41
Membranous glomerulonephritis and Landry-Guillain-Barre syndrome. (3766533)
1986
42
Hepatic glomerulonephritis. Characteristics of hepatic IgA glomerulonephritis as the major part. (7281501)
1981
43
Plasmapheresis in rapidly progressive glomerulonephritis. (707515)
1978
44
Haemolytic uraemic syndrome and idiopathic membranous glomerulonephritis. (638624)
1978
45
The influence of selective thrombocytopenia on immune complex glomerulonephritis. (152343)
1978
46
Relationship between glomerular lesions, serum creatinine and interstitial volume in membrano-proliferative glomerulonephritis. (886824)
1977
47
Plasma renin activity in acute poststreptococcal glomerulonephritis and the haemolytic-uraemic syndrome. (4372955)
1974
48
Glomerular fine structure in mixed membranous and proliferative glomerulonephritis. (5483389)
1970
49
Nephrotic syndrome in the cat due to diffuse membranous glomerulonephritis. (5408671)
1969
50
A consideration of diffuse glomerulonephritis. (18146355)
1949

Genetic Variations for Glomerulonephritis

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Expression for genes affiliated with Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glomerulonephritis

Search GEO for disease gene expression data for Glomerulonephritis.

Pathways for genes affiliated with Glomerulonephritis

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Sources:
12EMD Millipore, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 55SinoBiological
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Pathways related to Glomerulonephritis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Lectin induced complement pathway
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11.3CFP, C1QC, CFH, CFI, CR1, MBL2
2
Hide members
11.3C1QC, C1QA, C1QB, ICAM1, MBL2, CR1
311.3C1QC, C1QA, C1QB, ICAM1, MBL2, ITGAL
4
Hide members
11.2C1QC, C1QA, C1QB, MBL2, CR1, CFI
5
Hide members
11.2C1QC, C1QA, C1QB, ICAM1, MBL2, CR1
6
Hide members
11.0CFH, MBL2, C1QB, C1QA, C1QC
7
Hide members
10.9C1QC, C1QA, C1QB, CCL2
810.9ALB, MPO, ICAM1, CCL2
910.9C1QB, CCL2, ICAM1, TGFB1
1010.8C1QB, C1QA, C1QC
1110.8C1QB, C1QA, C1QC
12
Hide members
10.8CFP, CFH, CFI
1310.8CCL2, ICAM1, MPO
1410.7CR1, ITGAL
1510.6ITGAL

Compounds for genes affiliated with Glomerulonephritis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.4PRTN3, AGTR1, CFI, MPO, ITGAL, ALB
2retinoic acid44 2413.0CFH, CFI, TGFB1, ICAM1, CR1, ITGAL
3polysaccharide4411.9CR1, CCR5, CFP, CCL2, ICAM1, MBL2
4fibrinogen4411.9MBL2, CCL2, AGTR1, CD79A, CFI, CFH
5creatinine4411.9MPO, AGTR1, CFI, ALB, MBL2, CCL2
6alanine4411.8ALB, PRTN3, CFH, ITGAL, AGTR1, CCR5
7heparin44 28 11 2414.8CD79A, CCR5, CR1, ITGAL, MPO, CFI
8hyaluronic acid44 2412.8PRTN3, SCGB1A1, ICAM1, CD79A, CFH, ALB
9oxygen44 2412.7PRTN3, MPO, ITGAL, CR1, ICAM1, CCL2
10cholesterol44 28 11 2414.7AGTR1, CFI, CCR5, CCL2, CFH, ALB
11histamine44 28 2413.6ALB, TGFB1, CD79A, ICAM1, CCL2, MPO
12nitric oxide44 11 2413.5CR1, SCGB1A1, MBL2, MPO, ITGAL, AGTR1
13formaldehyde44 2412.5TGFB1, PRTN3, CD79A, MPO, CR1, CCL2
14mannose4411.5MBL2, CFP, CD79A, CCR5, ITGAL, CR1
15cisplatin44 49 59 1114.5CFH, CCL2, ITGAL, MPO, AGTR1, TGFB1
16efalizumab44 1112.5C1QC, C1QA, C1QB, ICAM1, ITGAL
17vitamin d4411.4CCR5, CCL2, CR1, AGTR1, CD79A
18cyclosporin a44 28 5913.4CFH, CD79A, ITGAL, CR1, ICAM1
19prednisolone44 28 1113.4CD79A, MPO, MBL2, ITGAL, CR1
20superoxide44 2412.4CFP, AGTR1, ITGAL, MBL2, CCL2
21methacholine44 1112.4TGFB1, CD79A, AGTR1, MPO, ICAM1
22n-formylmethionyl-leucylphenylalanine4411.4ICAM1, PRTN3, MPO, CR1, ITGAL
23rituximab44 49 1113.4C1QA, C1QC, C1QB, PRTN3, CD79A
24fmlp4411.4CR1, PRTN3, MPO, ITGAL, ICAM1
25polyethylene glycol4411.4ICAM1, CD79A, ALB, TGFB1, MPO
26dexamethasone44 49 28 1114.3CD79A, TGFB1, ITGAL, CFH
27dextran sulfate4411.3ICAM1, MPO, CCR5, CFP
28serine4411.3TGFB1, CCR5, MPO, CCL2, AGTR1, PRTN3
29natalizumab44 1112.3C1QA, C1QB, ICAM1, C1QC
30latex4411.3SCGB1A1, CCR5, CR1, ITGAL, MBL2
31ramipril44 1112.3AGTR1, CD79A, ALB, TGFB1
32adalimumab44 49 1113.3C1QB, CD79A, C1QA, C1QC
33tacrolimus44 49 1113.3ALB, CD79A, TGFB1, ITGAL
34mannan4411.2CFP, MBL2, CR1, CD79A
35candesartan44 28 1113.2TGFB1, ALB, AGTR1, CCL2
36rantes4411.2TGFB1, ITGAL, MBL2, ICAM1
37polymyxin b4411.2MBL2, CR1, CCL2, ICAM1
38cytochalasin d44 5912.2ITGAL, CCL2, ICAM1, CCR5, TGFB1
39sulfasalazine44 28 49 1114.2MPO, CCL2, CD79A, ICAM1
408-isoprostane4411.2AGTR1, ICAM1, CCL2, MPO
41simvastatin44 49 59 28 11 2416.1CCR5, ITGAL, ICAM1, CCL2, AGTR1
42anaphylatoxin4411.1CFP, MPO, CR1
43pge24411.0TGFB1, ITGAL
44thyroxine44 2411.9TGFB1, ALB, CFI, CD79A, MBL2
45cytochalasin b4410.9ICAM1, MPO, PRTN3, ITGAL
46Palivizumab1110.9C1QA, C1QC, C1QB
47cardiolipin44 1111.8CFH
48cycloheximide4410.7CR1
49diphenyleneiodonium4410.7MPO, TGFB1
50sodium cromoglycate4410.5CD79A, ICAM1, ITGAL

GO Terms for genes affiliated with Glomerulonephritis

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Sources:
16Gene Ontology
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Cellular components related to Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.6C1QC, C1QA, C1QB, CCL2, MBL2, CFI
2extracellular spaceGO:00561511.6TGFB1, CCL2, ICAM1, MBL2, SCGB1A1, MPO
3external side of plasma membraneGO:00989710.9CD79A, ITGAL, ICAM1, CCR5
4collagenGO:00558110.8C1QC, C1QA, C1QB, MBL2
5complement component C1 complexGO:00560210.4C1QB, C1QA

Biological processes related to Glomerulonephritis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508711.6C1QC, C1QA, C1QB, MBL2, CR1, CFI
2complement activationGO:00695611.4CFP, CFH, MBL2, C1QB, C1QA, C1QC
3complement activation, classical pathwayGO:00695811.4C1QC, C1QA, C1QB, MBL2, CR1, CFI
4regulation of complement activationGO:03044911.2CR1, CFI, CFH, CFP
5complement activation, alternative pathwayGO:00695711.0CFH, CFP, CFHR5
6MAPK cascadeGO:00016510.9CCR5, CCL2, TGFB1
7inflammatory responseGO:00695410.9TGFB1, ITGAL, CCL2, CCR5
8T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:00229110.9ITGAL, ICAM1
9negative regulation of phagocytosisGO:05076510.9TGFB1, PRTN3
10cellular response to lipopolysaccharideGO:07122210.9CCR5, CCL2, ICAM1
11response to cholesterolGO:07072310.8TGFB1, CCR5
12response to drugGO:04249310.8CCL2, ICAM1, SCGB1A1, TGFB1
13low-density lipoprotein particle remodelingGO:03437410.7AGTR1, MPO
14positive regulation of cellular protein metabolic processGO:03227010.4TGFB1, AGTR1

Products for genes affiliated with Glomerulonephritis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet