Glomerulonephritis malady

NIH Rare Diseases: Glomerulonephritis is a type of kidney disease in which there is inflammation of the glomeruli, the tiny filters that remove excess waste and fluids from the blood. It may be acute or chronic (coming on gradually), and may occur on its own (primary) or be caused by another condition (secondary). Signs and symptoms may depend on the type and cause of the condition and may include blood in the urine; foamy urine; swelling of the face, eyes, or other body parts; abdominal pain; high blood pressure; fatigue; and/or other symptoms. If the condition is severe or prolonged, the kidneys can become damaged. It may be caused by a variety of infections and diseases, and sometimes the cause is unknown. Treatment depends on the cause, type and severity of the condition.³⁰

MalaCards: Glomerulonephritis is related to crescentic glomerulonephritis and iga glomerulonephritis. An important gene associated with Glomerulonephritis is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are PTEN Pathway and Cell adhesion ECM remodeling. The compounds steroid and vegf have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and kidney, and related mouse phenotypes are hearing/vestibular/ear and mortality/aging.

Disease Ontology: A nephritis that causes inflammation of the glomeruli located in kidney.⁶

Wikipedia: Glomerulonephritis, also known as glomerular nephritis, abbreviated GN, is a renal disease (usually of...⁴⁴ more...

Aliases & Descriptions:

glomerulonephritis 6 30 8 32 43

Diseases related to glomerulonephritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 987)

id	Related Disease	Score	Top Affiliating Genes
1	crescentic glomerulonephritis	41.7	KIT, KITLG, VCAM1, VCAN, BMP6, CMA1
2	iga glomerulonephritis	38.8	VTN, SERPINB7, NAGLU, BMP6, SCGB1A1, CFH
3	proliferative glomerulonephritis	38.5	SELP, VEGFA, MPO, CD79A, CD36, CD55
4	membranous glomerulonephritis	37.0	LRP2, VTN, SERPINB7, CLU, CD79A, CD59
5	proteinuria	35.9	LRP2, REN, VWF, VTN, RBP4, SELP
6	rapidly progressive glomerulonephritis	35.3	LCA10, MPO, CCL2, ICAM1, TNF, CRP
7	acute poststreptococcal glomerulonephritis	35.3	SFMBT1, SERPINF2, LEO1, CFP, CD79A, CCL2
8	mesangial proliferative glomerulonephritis	35.1	LIF, AXL, CD79A, FN1, IL6, MBL2
9	nephropathy	34.7	LRP2, REN, SGK1, KITLG, VWF, VTN
10	immune-complex glomerulonephritis	34.6	SELP, VCAM1, CFI, MPO, FTH1, CD40LG
11	membranoproliferative glomerulonephritis type 2	34.6	VTN, CFH, CFP, CD79A, CD46, MBL2
12	chronic rapidly progressive glomerulonephritis	33.9	SERPINE1, NAGLU, SCGB1A1, B2M, CD79A, FN1
13	berger disease	33.2	SERPINB7, NAGLU, BMP6, SCGB1A1, MUC20, CD79A
14	nephritis	32.9	LRP2, REN, VWF, VTN, PCNA, RBP4
15	lupus nephritis	32.3	VWF, VTN, PCNA, RBP4, SERPINE1, NAGLU
16	hepatitis	31.6	RBP4, SELP, GZMB, ARG1, GSR, FAS
17	lipoid nephrosis	31.5	SERPINB7, NAGLU, CD79A, ITGB1, IL13, IL4R
18	vasculitis	31.4	REN, VWF, SELP, SERPINC1, SERPING1, VEGFA
19	nephrotic syndrome	31.4	LRP2, REN, KITLG, VWF, VTN, PCNA
20	systemic lupus erythematosus	31.1	LRP2, VWF, VTN, RBP4, SERPINH1, VCAM1
21	glomerulopathy	30.5	LRP2, REN, VWF, SELP, NAGLU, BMP6
22	hepatitis b	30.5	IL10, IL17A, IL18, IL2RA, MBL2, CCR5
23	aldosteronism	30.4	REN, SGK1, SERPINE1, NAGLU, VEGFA, BMP6
24	end stage renal failure	30.3	SELP, VEGFA, BGLAP, CD79A, FN1, INS
25	rheumatoid arthritis	30.1	IL1R1, IL1RN, MBL2, HLA-DRB1, TNFRSF1A, CRP
26	alport syndrome	30.0	BMP6, KCNE1L, LAMB1, CD79A, ITGA2, AMMECR1
27	purpura	29.7	VWF, SELP, SERPINC1, SERPINF2, SERPINE1, VEGFA
28	hemolytic-uremic syndrome	29.6	VWF, SELP, SERPINC1, SERPINE1, CLU, CFH
29	arthritis	29.6	IL17A, IL1B, IL6, IL8, TNF, TNFRSF1A
30	pyelonephritis	29.4	NAGLU, B2M, CD79A, CD40LG, CD55, MMP9
31	castleman's disease	29.1	VEGFA, B2M, IL10, IL6, CCL4, IFNA1
32	macular degeneration	29.1	VWF, VTN, SELP, SERPINE1, SERPING1, VEGFA
33	endocarditis	29.0	VWF, SERPINC1, SERPINH1, VCAM1, LMNA, LAP3
34	liver cirrhosis	28.8	REN, VTN, RBP4, SERPINC1, SERPINF2, LIF
35	age related macular degeneration	28.8	VTN, SERPINE1, SERPING1, VEGFA, CLU, PARP1
36	cryoglobulinemia	28.8	VWF, VCAM1, BMP6, BCL2, CD79A, CD40LG
37	atypical hemolytic-uremic syndrome	28.7	CFH, CFHR1, CFHR3, CFI, CD46, THBD
38	hematuria	28.7	NAGLU, CFP, CD79A, CD40LG, FN1, INS
39	hemolytic anemia	28.6	VWF, LCAT, CFH, CD59, CD55, IFNA2
40	chronic myeloid leukemia	28.4	KIT, KITLG, SELP, RAP1A, RARA, BCL2
41	angioedema	28.3	SERPINC1, SERPING1, LCAT, MME, IL2, IL6
42	polycythemia vera	28.3	KIT, KITLG, VWF, SELP, SERPINC1, SERPINE1
43	nephrosis	28.2	SERPINC1, SERPINF2, RARA, LAMB1, B2M, MME
44	anemia	28.2	REN, SGK1, KIT, KITLG, VWF, PCNA
45	nephrosclerosis	28.2	SERPINC1, SERPINE1, LCAT, MTHFR, MPO, INS
46	hepatitis c	28.2	CD40LG, GSR, IL10, IL18, IL2, IL4
47	fibrosis	28.2	REN, SGK1, KIT, KITLG, VWF, VTN
48	chronic obstructive pulmonary disease	27.9	PARP1, SCGB1A1, MPO, MMP9, GZMB, AREG
49	polycythemia	27.8	KIT, KITLG, VWF, SELP, SERPINC1, SERPINE1
50	bullous pemphigoid	27.8	SERPINF2, VEGFA, VCAM1, LAMA3, MPO, CD79A

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to glomerulonephritis:

²²

FMA organs/tissues related to glomerulonephritis:

¹¹

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Kidney -> Glomerulus	Affected by disease

MGI Mouse Phenotypes related to glomerulonephritis:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	INF	LRP2, KIT, KITLG, NAGLU, LMNA, RARA
2	mortality/aging	MP:0010768	INF	REN, KITLG, VWF, SELP, SERPINC1, SERPINH1
3	immune system phenotype	MP:0005387	INF	REN, KIT, VWF, SELP, VIM, NAGLU
4	cellular phenotype	MP:0005384	INF	LRP2, KIT, KITLG, VWF, PCNA, RBP4
5	integument phenotype	MP:0010771	INF	KIT, KITLG, SELP, BSX, , LIF
6	endocrine/exocrine gland phenotype	MP:0005379	INF	LRP2, BSX, LALBA, CD40LG, IL2, IFNG
7	reproductive system phenotype	MP:0005389	INF	REN, RBP4, BSX, VEGFA, LMNA, RARA
8	renal/urinary system phenotype	MP:0005367	INF	LRP2, REN, SGK1, KIT, SELP, NAGLU
9	nervous system phenotype	MP:0003631	10.5	REN, KIT, KITLG, VWF, SELP, SERPINC1
10	no phenotypic analysis	MP:0003012	10.1	LRP2, SGK1, PCNA, VEGFA, VCAM1, MYOC
11	other phenotype	MP:0005395	9.4	SERPINH1, BSX, RARA, CLU, CD40LG, ITGB1
12	adipose tissue phenotype	MP:0005375	8.3	SERPINE1, BSX, LMNA, LIF, BCL2, CD36
13	liver/biliary system phenotype	MP:0005370	8.3	KIT, SERPINC1, VEGFA, LIF, LCAT, FTH1
14	tumorigenesis	MP:0002006	7.7	KIT, KITLG, SERPINE1, RARA, BCL2, SCGB1A1
15	vision/eye phenotype	MP:0005391	7.6	LRP2, KIT, KITLG, RBP4, SELP, SERPINC1
16	embryogenesis phenotype	MP:0005380	INF	KIT, SERPINC1, VIM, , PARP1, JUND
17	muscle phenotype	MP:0005369	INF	REN, KIT, RBP4, VIM, VEGFA, LMNA
18	respiratory system phenotype	MP:0005388	INF	LRP2, SELP, , LIF, SCGB1A1, ITGB3
19	growth/size phenotype	MP:0005378	INF	LRP2, REN, SGK1, KIT, KITLG, SELP
20	hematopoietic system phenotype	MP:0005397	INF	KIT, PCNA, RAP1A, BCL2, P2RX7, AXL
21	normal phenotype	MP:0002873	INF	REN, VTN, RBP4, SERPING1, BSX, VEGFA
22	behavior/neurological phenotype	MP:0005386	INF	LRP2, REN, KIT, SELP, VIM, BSX
23	cardiovascular system phenotype	MP:0005385	INF	REN, KIT, KITLG, VWF, RBP4, SELP
24	digestive/alimentary phenotype	MP:0005381	INF	LRP2, KIT, KITLG, VWF, VEGFA, LMNA
25	craniofacial phenotype	MP:0005382	INF	LRP2, KIT, KITLG, NAGLU, , LAMA3
26	homeostasis/metabolism phenotype	MP:0005376	INF	LRP2, REN, SGK1, KIT, KITLG, VWF
27	limbs/digits/tail phenotype	MP:0005371	INF	KIT, KITLG, VEGFA, VCAN, LMNA, RARA
28	skeleton phenotype	MP:0005390	INF	LRP2, KIT, KITLG, NAGLU, VEGFA, VCAN

Articles related to glomerulonephritis:

(show top 50)    (show all 545)

id	Title	Authors	Year	Affiliating Genes
1	Negative regulation of inflammatory responses by immu noglobulin A receptor (FcI+RI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis. (21985370)	Watanabe T.... Tomino Y.	2011	FCAR
2	Effects of uridine diphosphate glucuronosyltransferas e 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. (20567810)	Joy M.S.... Smith P.C.	2010	ABCB1, UGT2B7, UGT1A7
3	Differential deposition of C4d and MBL in glomeruli o f patients with ANCA-negative pauci-immune crescentic glomerulonephritis. (19898926)	Xing G.Q.... Zhao M.H.	2010	MBL2
4	Concomitant severe normocytic and normochromic anemia in poststreptococcal acute glomerulonephritis. (19915313)	Asano T.... Fujino O.	2009	EPO
5	Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. (19524415)	Wu J.G.... Zhang Y.G.	2009	SOD1, ALB
6	Prognostic factors in children with membranoproliferative glomerulonephritis type I. (18297315)	GarcA-a-de la Puente S.... de Leon Bojorge B.	2008	ALB
7	Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. (17914026)	Fang C.J.... Atkinson J.P.	2008	CD46
8	Pathological regression by angiotensin II type 1 receptor blockade in patients with mesangial proliferative glomerulonephritis. (18497456)	Ohtake T.... Kobayashi S.	2008	AGTR1
9	Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. (16482158)	Aitman T.J.... Cook H.T.	2006	FCGR3B
10	The role of podocytes in normal glomerular function and in the pathogenesis of glomerulonephritis. Part II. Phenotypic and functional changes of podocytes in glomerulonephritis (16702925)	Kubiak A.... Niemir Z.I.	2006	MME
11	Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis. (16138437)	Genel F.... Truedsson L.	2005	CFI
12	Etiology of increased enzymuria in different morphological forms of glomerulonephritis. (15503426)	Kuzniar J.... Klinger M.	2004	NAGLU
13	Staphylococcus aureus antigens induce IgA-type glomerulonephritis in Balb/c mice. (15372411)	Sharmin S.... Koyama A.	2004	CD79A
14	Circumvention of normal constraints on granule protein gene expression in peripheral blood neutrophils and monocytes of patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. (15284296)	Yang J.J.... Preston G.A.	2004	MPO, PRTN3
15	CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis. (14742268)	Segerer S.... Grone H.J.	2004	CXCR3
16	Interaction between gene polymorphisms of nitric oxide synthase and renin-angiotensin system in the progression of membranous glomerulonephritis. (14767013)	Stratta P.... Matullo G.	2004	NOS3, ACE, AGTR1
17	Crescentic glomerulonephritis and subepidermal blisters with autoantibodies to alpha5 and alpha6 chains of type IV collagen. (12746470)	Ghohestani R.F.... Uitto J.	2003	LAMA3, DST
18	Blocking VLA-4 prevents progression of experimental crescentic glomerulonephritis. (14646362)	Khan S.B.... Pusey C.D.	2003	ITGA4
19	A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis. (12897205)	Huang Y.... Noble N.A.	2003	TGFB1, SERPINE1, VTN
20	Tubular osteopontin expression in patients with ANCA-associated glomerulonephritis. (11770797)	Nitta K.... Nihei H.	2001	SPP1, MPO
21	The expression of cytoskeletal proteins (alpha-SMA, vimentin, desmin) in kidney tissue: a comparison of fetal, normal kidneys, and glomerulonephritis. (12092643)	Gonlusen G.... Tunali N.	2001	VIM, DES
22	Renin-angiotensin system genes in chronic glomerulonephritis (11865575)	Buraczynska M.... Ksiazek A.	2001	ACE, AGTR1, AGT
23	Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis. (11181795)	Ito Y.... Aten J.	2001	CTGF
24	A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats. (10906168)	Wada T.... Yokoyama H.	2000	CCL2
25	Increased plasma levels of mature adrenomedullin in chronic glomerulonephritis. (11096291)	Kinoshita H.... Eto T.	2000	ADM
26	A case of relapse of C-ANCA-associated glomerulonephritis in post-transplant patients. (11092351)	Oka K.... Hori M.	2000	PRTN3
27	Nitric oxide and glomerulonephritis. (10226334)	Cattell V.	1999	NOS2
28	Assessment of urinary endothelin-1 and nitric oxide levels and their relationship with clinical and pathologic types in primary glomerulonephritis. (10565251)	Duan S.B.... Peng Y.M.	1999	EDN1
29	Expression of TGF-beta receptors type I and II in human glomerulonephritis. (9509435)	Onetti Muda A.... Faraggiana T.	1998	TGFBR1
30	Myofibroblasts and the progression of crescentic glomerulonephritis. (9681707)	Goumenos D.... el Nahas A.M.	1998	BMP6
31	Plasma soluble fas and soluble fas ligand in chronic glomerulonephritis. (9736812)	Sano H.... Fujiwara H.	1998	FAS
32	Transforming growth factor-beta, endothelin-1, and c-fos expression in necrotizing/crescentic IgA glomerulonephritis. (9681709)	Rastaldi M.P.... D'amico G.	1998	BMP6
33	Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress collagen accumulation in experimental glomerulonephritis. (9714184)	Sunamoto M.... Doi T.	1998	SERPINH1
34	Renal hemodynamics and proteinuria in chronic glomerulonephritis treated with beta-receptor blockers or ace inhibitors (9280714)	Erley C.M.... Risler T.	1997	ACE
35	A new variant of IgA mesangial deposit glomerulonephritis with focal-segmental sclerosis and an anomalous clinical picture (9489406)	Monga G.	1997	CD79A
36	Glomerular expression of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in patients with various forms of glomerulonephritis. (8804363)	Matsuda M.... Ota Z.	1996	CSF2, CSF1
37	Platelet-activating factor levels and PAF acetylhydrolase activities in patients with primary glomerulonephritis. (8730430)	Iatrou C.... Ziroyiannis P.	1996	PLA2G7
38	HLA-DP antigens and post-streptococcal acute glomerulonephritis. (8863870)	Mori K.... Ito Y.	1996	HLA-DQA1, HLA-DRB1, HLA-DPB1
39	Transforming growth factor beta (TGF beta) activity in urine of patients with glomerulonephritis. (8634677)	Dominguez G.C.... Coimbra T.M.	1995	BMP6
40	Occurrence of autoantibodies directed against myeloperoxidase and elastase in patients treated with hydralazine and presenting with glomerulonephritis. (7946512)	Torffvit O.... NAossberger L.	1994	MPO, ELANE
41	Enhanced presence of thrombomodulin in the glomeruli of lupus glomerulonephritis. (8026112)	Tomura S.... Aoki N.	1994	THBD
42	In situ production of TNF-alpha, IL-1 beta and IL-2R in ANCA-positive glomerulonephritis. (8455368)	Noronha I.L.... Waldherr R.	1993	TNF, IL1B
43	The cytochemical characteristics of the epithelium o f the proximal nephron and of the endothelium of the peritubular capillaries an d kidney functional status in chronic glomerulonephritis patients (8310583)	Kaiukov I.G.... Abissova N.A.	1993	SDHB
44	Immunologic characteristics of fibrillary glomerulonephritis. (1363752)	Rollino C.... Aimo G.	1992	IL1B, B2M
45	Accelerated decay of the cell bound C4b2a complex by serum of patients with membranoproliferative glomerulonephritis and acute posts treptococcal glomerulonephritis. (1541053)	Tanuma Y.... Hatano M.	1992	C4BPA
46	Double monoclonal cryoglobulinemia, glomerulonephritis and lymphoma. (1300443)	Rollino C.... Cordonnier D.	1992	CD79A
47	Arterial hypertension in glomerulonephritis (1795479)	Shulutko B.I.	1991	GSR
48	Classic and perinuclear anti-neutrophil cytoplasm antibodies and antimyeloperoxidase antibodies in rapidly progressive glomerulonephritis. (1665954)	Rollino C.... Piccoli G.	1991	MPO
49	Interrelations of blood pressure, glomerular filtration rate, protein clearances and sodium excretion in patients with glomerulonephritis and diabetic nephropathy. (2115624)	Ala-Houhala I.... Pasternack A.	1990	ALB, B2M
50	Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis. (2155342)	Tervaert J.W.... Kallenberg C.G.	1990	MPO, ELANE

Genes related to glomerulonephritis according to GeneCards:

(show top 50)    (show all 314)

id	Symbol	Description	Score	GeneCards Section Context
1	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.1	Publications, Summaries
2	CFHR5	complement factor H-related 5	11.1	Summaries, Publications
3	CFI	complement factor I	11.0	Publications, Summaries
4	C1QB	complement component 1, q subcomponent, B chain	11.0	Summaries
5	C1QC	complement component 1, q subcomponent, C chain	11.0	Summaries
6	C1QA	complement component 1, q subcomponent, A chain	11.0	Summaries
7	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
8	MPO	myeloperoxidase	11.0	Publications
9	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
10	ICAM1	intercellular adhesion molecule 1	11.0	Publications
11	ALB	albumin	11.0	Publications
12	CFH	complement factor H	11.0	Publications
13	CFP	complement factor properdin	11.0	Publications
14	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
15	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
16	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
17	TGFB1	transforming growth factor, beta 1	11.0	Publications
18	AGTR1	angiotensin II receptor, type 1	11.0	Publications
19	PRTN3	proteinase 3	11.0	Publications
20	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
21	C3	complement component 3	11.0	Publications
22	MME	membrane metallo-endopeptidase	11.0	Publications
23	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
24	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
25	TSLP	thymic stromal lymphopoietin	11.0	Publications
26	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
27	CCR1	chemokine (C-C motif) receptor 1	11.0	Publications
28	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
29	GAS6	growth arrest-specific 6	11.0	Publications
30	PF4	platelet factor 4	11.0	Publications
31	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)	11.0	Publications
32	CTGF	connective tissue growth factor	11.0	Publications
33	OXA1L	oxidase (cytochrome c) assembly 1-like	11.0	Publications
34	EDNRB	endothelin receptor type B	11.0
35	ELANE	elastase, neutrophil expressed	11.0	Publications
36	CD40LG	CD40 ligand	11.0	Publications
37	BMP6	bone morphogenetic protein 6	11.0	Publications
38	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0	Publications
39	FN1	fibronectin 1	11.0	Publications
40	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
41	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
42	EDN1	endothelin 1	11.0	Publications
43	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
44	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	11.0	Publications
45	VEGFA	vascular endothelial growth factor A	11.0	Publications
46	TNF	tumor necrosis factor	11.0	Publications
47	PTPRQ	protein tyrosine phosphatase, receptor type, Q	11.0	Publications
48	THY1	Thy-1 cell surface antigen	11.0	Publications
49	SYNPO	synaptopodin	11.0	Publications
50	AMBP	alpha-1-microglobulin/bikunin precursor	11.0	Publications

Pathways related to glomerulonephritis according to GeneDecks:

(show top 50)    (show all 157)

id	Pathway	Score	Top Affiliating Genes
1	PTEN Pathway36	INF	KIT, KITLG, LAMA3, LAMB1, ITGA2, ITGA4
2	Cell adhesion ECM remodeling10	INF	VTN, SERPINE1, VCAN, LAMA3, LAMB1, CD44
3	Cell adhesion Plasmin signaling10	INF	SERPING1, VEGFA, LAMB1, FN1, FGF2, MAPK14
4	Focal adhesion20	INF	VWF, VTN, RAP1A, BCL2, LAMA3, LAMB1
5	Cell adhesion_Plasmin signaling41	INF	SERPING1, VEGFA, LAMB1, FN1, FGF2, MAPK14
6	Cell adhesion_ECM remodeling41	INF	VTN, SERPINE1, VCAN, LAMA3, LAMB1, CD44
7	Immune response_Lectin induced complement pathway41	11.5	SERPING1, CLU, CFI, CD59, CD55, CD46
8	Malaria20	11.3	SELP, VCAM1, CD36, CD40LG, ITGAL, ITGB2
9	Glioma Invasiveness36	11.3	KITLG, VTN, BMP6, CD44, ITGA4, ITGA8
10	Rac1 Pathway36	10.8	KITLG, BMP6, ITGA2, ITGA4, ITGA8, ITGAL
11	Actin-Based Motility by Rho Family GTPases36	10.8	ITGA4, ITGA8, ITGAL, AREG, IL2, CTGF
12	Akt Signaling36	10.6	KIT, LIF, AXL, ITGA2, ITGA8, ITGAL
13	Renin-Angiotensin Pathway36	10.5	REN, KIT, KITLG, VCAM1, BMP6, FLT1
14	Chagas disease (American trypanosomiasis)20	10.1	SERPINE1, IL10, IL1B, IL2, IL6, IL8
15	Apoptotic Pathways in Synovial Fibroblasts36	10.0	KIT, KITLG, BMP6, FLT1, AREG, FGF2
16	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	GZMB, IL17A, IL1B, IL4, IL4R, IL6
17	PPAR Pathway36	9.9	KIT, KITLG, ITGA2, ITGA4, ITGA8, ITGAL
18	Leishmaniasis20	9.9	ITGA4, ITGB1, ITGB2, FCGR3B, IL10, IL1B
19	Influenza A20	9.7	IL18, IL1B, IL6, IL8, FAS, MAPK14
20	Regulation of eIF4 and p70S6K36	9.7	ITGA2, ITGA4, ITGA8, ITGAL, ITGB1, ITGB2
21	p70S6K Signaling36	9.5	KIT, KITLG, BMP6, FLT1, AREG, INS
22	Rheumatoid arthritis20	9.5	VEGFA, ITGAL, ITGB2, FLT1, IL17A, IL18
23	Cytokine Network36	9.2	IL10, IL13, IL18, IL1B, IL2, IL4
24	Tuberculosis20	9.2	BCL2, LAMP2, ITGB2, FCGR3B, IL10, IL18
25	MIF Mediated Glucocorticoid Regulation36	9.1	BMP6, LIF, BCL2, MIF, IL10, IL13
26	all-trans-Retinoic Acid Signaling in Brain36	9.1	BMP6, RARA, LIF, BCL2, IL10, IL13
27	MAPK Family Pathway36	8.8	KITLG, BMP6, BCL2, FLT1, AREG, FGF2
28	MIF Regulation of Innate Immune Cells36	8.6	BMP6, LIF, BCL2, MIF, IL10, IL13
29	TGF-Beta Pathway36	8.6	KITLG, BMP6, BCL2, FLT1, AREG, FGF2
30	PGC1Alpha Pathway36	8.2	BMP6, BCL2, INSR, IL13, IL18, IL1B
31	Antioxidant Action of Vitamin-C36	INF	KIT, KITLG, BMP6, LIF, BCL2, FLT1
32	JAK-STAT Pathway36	INF	KIT, KITLG, BMP6, BCL2, AXL, FLT1
33	Complement and coagulation cascades20	INF	VWF, SERPINC1, SERPINF2, SERPINE1, SERPING1, CFH
34	14-3-3 Induced Intracellular Signaling36	INF	KITLG, AXL, FLT1, AREG, INSR, FGF2
35	Cytokine-cytokine receptor interaction20	INF	KIT, KITLG, VEGFA, LIF, CD40LG, FLT1
36	Tec Kinases Signaling36	INF	KITLG, BMP6, BCL2, ITGA2, ITGA4, ITGA8
37	Ras Pathway36	INF	KIT, RAP1A, AXL, ITGA2, ITGA4, ITGA8
38	Pancreatic Adenocarcinoma36	INF	KIT, KITLG, BMP6, BCL2, AXL, MMP11
39	Paxillin Interactions36	INF	KIT, KITLG, AXL, ITGA2, ITGA4, ITGA8
40	MAPK Signaling36	INF	KIT, KITLG, BMP6, RAP1A, BCL2, LAMA3
41	Hematopoietic cell lineage20	INF	KIT, KITLG, MS4A1, CD36, CD59, CD34
42	ERK Signaling36	INF	KIT, KITLG, BMP6, RAP1A, LAMA3, LAMB1
43	Molecular Mechanisms of Cancer36	INF	KITLG, BMP6, RAP1A, RARA, LIF, BCL2
44	STAT3 Pathway36	INF	BMP6, LIF, BCL2, IL10, IL13, IL18
45	Rho Family GTPases36	INF	KIT, KITLG, VIM, BMP6, LIF, BCL2
46	Immune response_Classical complement pathway41	INF	SERPING1, CLU, CFI, CD59, CD55, CD46
47	p38 Signaling36	INF	KIT, KITLG, BMP6, LIF, BCL2, AXL
48	Endothelin-1 Signaling Pathway36	INF	KIT, BMP6, AXL, FLT1, INSR, IL10
49	Pertussis20	INF	SERPING1, ITGB1, ITGB2, IL10, IL1B, IL6
50	Pathways in cancer20	INF	VEGFA, RARA, BCL2, LAMB1, ITGA2, ITGB1

Compounds related to glomerulonephritis according to GeneDecks:

(show top 50)    (show all 493)

id	Compound	Score	Top Affiliating Genes
1	steroid32	INF	LRP2, REN, SGK1, KIT, KITLG, RBP4
2	vegf32	INF	REN, KIT, KITLG, VWF, VTN, PCNA
3	serine32	INF	LRP2, SGK1, KIT, KITLG, VWF, VTN
4	dexamethasone32 42 34 9 9	INF	REN, SGK1, KITLG, VWF, VTN, PCNA
5	sialic acid32	11.8	RBP4, SERPINF2, NAGLU, CLU, S100B, CFH
6	carbohydrates32	11.6	SELP, VCAM1, LALBA, CFI, FUT4, CD44
7	sucrose32 9 18 9	14.4	LRP2, RBP4, MYOC, RARA, LAMP2, CD59
8	leukotriene b432 42 18	13.3	SELP, LAP3, MPO, ITGAL, ITGB2, MMP9
9	thromboxane a232 18	12.3	VWF, SELP, NAGLU, LIF, ITGA2, F2R
10	pmma32	11.1	VTN, SELP, BMP6, B2M, CD40LG, FN1
11	polyethylene glycol32	11.1	KITLG, VTN, SERPINC1, LALBA, MPO, FN1
12	isoproterenol32 9 9	13.0	VIM, RAP1A, LIF, ITGAL, INSR, FGF2
13	cyclic amp32 18	12.0	SGK1, RAP1A, LIF, KCNH1, JUND, ITGA4
14	methylcellulose32	10.9	KIT, KITLG, LIF, CD59, CD34, FGF2
15	pge232	10.9	REN, VTN, VCAM1, RAP1A, LIF, P2RX7
16	alginate32	10.8	VCAN, LIF, BGLAP, CD79A, CD36, CD44
17	bromodeoxyuridine32	10.8	KITLG, PCNA, VIM, BMP6, SCGB1A1, S100B
18	ascorbic acid32 18	11.8	PCNA, RBP4, SERPINH1, MYOC, LIF, BGLAP
19	gp 13032	10.7	KIT, BMP6, LIF, SCGB1A1, IL13, IL1R1
20	sodium nitroprusside32	10.6	REN, VWF, PCNA, BMP6, S100B, MME
21	epsilon aminocaproic acid32	10.5	SERPINC1, SERPINF2, SERPINE1, APOB, F9, F3
22	nifedipine32 9 9	12.5	REN, SERPINE1, NAGLU, BMP6, BGLAP, B2M
23	tetracycline32 9 9	12.4	VWF, BGLAP, SCGB1A1, S100A8, CD40LG, MMP2
24	aebsf32	10.3	PARP1, CFI, IL8, MAPK14, F3, TNF
25	clopidogrel32 34 9 18 9	14.1	SERPINC1, CD40LG, F2R, HMGCR, PTGS1, PPBP
26	lipoteichoic acid32	10.1	IL10, IL18, IL1B, IL1R1, IL1RN, IL6
27	zidovudine32 9 9	12.1	KITLG, UGT1A7, UGT2B7, B2M, IL10, IL2
28	tarc32	10.1	ITGA4, IL10, IL13, IL18, IL4, IL4R
29	bleomycin32 9 9	12.1	LAP3, CDKN3, CD44, FGF2, IL13, IL2RA
30	hydroxyurea32 9 9	12.0	KIT, KITLG, PCNA, VCAM1, ITGA4, IL10
31	15-deoxy-delta-12,14-prostaglandin j232	9.8	SERPINE1, VEGFA, VCAM1, BMP6, CD36, FGF2
32	8-isoprostane32	9.8	SERPINE1, VCAM1, MPO, MMP2, MMP9, INS
33	estrogen32	9.8	VWF, PCNA, RBP4, SERPINC1, SERPINE1, RARA
34	glutamine32	9.6	KIT, VWF, VTN, PCNA, SERPINF2, VIM
35	staurosporin32	9.5	BCL2, CDKN3, ITGAL, IL8, MAPK14, CASP1
36	ly29400232	9.4	SGK1, VTN, VEGFA, RARA, CDKN3, CD44
37	il-1232	9.4	CD40LG, IL10, IL13, IL18, IL1B, IL1R1
38	ribavirin32 34 9 9	12.1	CD40LG, MMP2, MMP9, IL10, IL18, IL2
39	pdtc32	7.8	VCAM1, PARP1, BCL2, MMP2, MMP9, IL18
40	resveratrol32 9 18 9	10.5	PCNA, VEGFA, PARP1, BCL2, MMP2, MMP9
41	paclitaxel32 34 9 9	10.3	KIT, KITLG, PCNA, VIM, VEGFA, BMP6
42	tyrosine32	INF	SGK1, KIT, KITLG, VWF, VTN, SELP
43	imatinib32 34 9 9	INF	KIT, KITLG, VEGFA, BMP6, RARA, PARP1
44	rituximab32 34 9 9	INF	BCL2, MS4A1, CD79A, CD59, CD40LG, CD55
45	etanercept32 9 9	INF	FCGR3B, IL10, IL17A, IL18, IL1B, IL1R1
46	phospholipid32	INF	LRP2, VWF, RBP4, CLU, SCGB1A1, LCAT
47	fenofibrate32 9 9	INF	SELP, SERPINE1, VIM, VCAM1, CD40LG, MMP9
48	h2o232	INF	SGK1, KITLG, VWF, NAGLU, LIF, CLU
49	threonine32	INF	RAP1A, IFNB1, F9, F2R, CYP11B2, CTLA4
50	aspirin32 34 18	INF	KITLG, VWF, VTN, PCNA, SELP, SERPINC1

Cellular components related to glomerulonephritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	11.4	ARG1, MBL2, MASP1, CCL4, CCL2, CCL3
2	platelet alpha granule lumen	GO:031093	11.3	ALB, PPBP, PLG, PF4, PDGFB, ACTN4
3	extracellular matrix	GO:031012	10.8	COL18A1, NID1, TIMP3, THBS1, TGFB2, DCN
4	external side of plasma membrane	GO:009897	10.7	KIT, VWF, SELP, VCAM1, P2RX7, B2M
5	membrane raft	GO:045121	10.5	TNFRSF1B, ABCA1, TLR4, THY1, PRKCA, NPHS1
6	cell surface	GO:009986	INF	VEGFA, IL1R1, CCR5, HSPA5, TNF, TNFRSF1A
7	extracellular region	GO:005576	INF	AMBP, PPBP, CRP, PLA2G7, PLA2R1, PLAT
8	integral to plasma membrane	GO:005887	INF	ABCA1, EDNRB, PDGFRB, PLA2R1, CR1, CTLA4
9	plasma membrane	GO:005886	INF	PRKCB, C3, GGT1, MYH9, C5AR1, EBI3

Biological processes related to glomerulonephritis according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:008284	INF	KIT, VEGFA, RARA, LIF, ITGB1, FLT1
2	innate immune response	GO:045087	INF	SERPING1, CLU, BCL2, S100A12, S100B, P2RX7
3	extracellular matrix organization	GO:030198	INF	SERPINH1, CMA1, ITGA8, MMP11, MMP2, MMP9
4	cell adhesion	GO:007155	11.9	KITLG, VWF, VTN, SELP, VCAM1, VCAN
5	regulation of complement activation	GO:030449	11.6	CFH, CFI, CFP, CD55, CD46, CR1
6	platelet activation	GO:030168	11.4	VWF, SELP, SERPINF2, SERPINE1, SERPING1, VEGFA
7	platelet degranulation	GO:002576	11.4	VWF, SELP, SERPINF2, SERPINE1, SERPING1, VEGFA
8	cell surface receptor signaling pathway	GO:007166	11.3	P2RX7, CD36, CD59, MIF, IL1R1, IL27RA
9	aging	GO:007568	11.1	LRP2, VCAM1, IL1B, FAS, CCL2, F3
10	leukocyte migration	GO:050900	11.1	SELP, CD34, ITGA4, ITGAL, ITGB1, ITGB2
11	positive regulation of MAP kinase activity	GO:043406	11.1	KITLG, VEGFA, FLT1, TNF, PDE5A, PDGFB
12	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.9	CLU, INS, GREM1, IL1B, IL6, ICAM1
13	neutrophil chemotaxis	GO:030593	10.9	ITGB2, IL1B, IL8, CCL2, CCL3, IFNG
14	response to amino acid stimulus	GO:043200	10.9	ARG2, ARG1, CCL2, ICAM1, TNFRSF1A, CTGF
15	chemotaxis	GO:006935	10.8	S100A8, S100A9, FGF2, IL4, MAPK14, MAPK1
16	response to mechanical stimulus	GO:009612	10.8	BGLAP, P2RX7, MMP9, CCL2, F3, TNF
17	positive regulation of tumor necrosis factor production	GO:032760	10.7	CD36, IL18, CCL3, IFNG, TNFRSF1A, PF4
18	cellular response to lipopolysaccharide	GO:071222	10.7	SERPINE1, AXL, CD36, ARG2, ARG1, IL10
19	positive regulation of protein kinase B signaling cascade	GO:051897	10.7	AXL, INS, INSR, CCL3, F3, HPSE
20	positive regulation of angiogenesis	GO:045766	10.6	SERPINE1, VEGFA, CD34, MMP9, FLT1, FGF2
21	positive regulation of smooth muscle cell proliferation	GO:048661	10.6	SERPINF2, FLT1, IL13, IL6, HMOX1, TNF
22	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.6	S100A12, S100B, CD36, IL1B, F2R, CASP1
23	response to organic cyclic compound	GO:014070	10.5	SELP, P2RX7, IL1RN, IL4, ICAM1, CASP1
24	blood coagulation	GO:007596	10.5	VWF, SELP, SERPINC1, SERPINF2, SERPINE1, SERPING1
25	positive regulation of inflammatory response	GO:050729	10.5	SERPINE1, IL18, IL2, CCL3, TNFRSF1A, PLA2G7
26	response to lipopolysaccharide	GO:032496	10.5	SELP, S100A8, S100A9, P2RX7, MMP9, IL13
27	activation of MAPK activity	GO:000187	10.4	KIT, MUC20, P2RX7, INSR, FGF2, IL1B
28	response to glucocorticoid stimulus	GO:051384	10.3	SERPINE1, BGLAP, LCAT, INSR, IL10, IL1B
29	positive regulation of MAPK cascade	GO:043410	10.2	KIT, LIF, P2RX7, CD36, ITGB1, FLT1
30	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.1	CD36, MAPK14, TP53, PDGFB, PDGFRB, AGT
31	cell-cell signaling	GO:007267	10.1	LALBA, S100A9, ITGB2, INS, GREM1, IL10
32	immune response	GO:006955	10.1	VTN, BMP6, LIF, CFP, MS4A1, FTH1
33	negative regulation of cell proliferation	GO:008285	10.0	LIF, FTH1, CDKN3, ITGB1, FGF2, IL1B
34	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.0	KITLG, VTN, VEGFA, LIF, CD36, CD44
35	angiogenesis	GO:001525	9.9	SERPINE1, VEGFA, MMP2, FN1, IL18, IL8
36	positive regulation of apoptotic process	GO:043065	9.5	CLU, P2RX7, ITGB1, MMP9, IL1B, FAS
37	apoptotic process	GO:006915	9.2	SGK1, VIM, LMNA, BCL2, ITGB2, GZMB
38	response to hypoxia	GO:001666	9.1	VEGFA, VCAM1, BCL2, MMP9, FLT1, ARG2
39	response to ethanol	GO:045471	8.9	RBP4, BGLAP, BCL2, S100A8, S100A9, MMP9
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.9	SERPINF2, SERPINE1, BSX, VEGFA, BMP6, RARA
41	response to drug	GO:042493	8.7	LRP2, REN, BGLAP, BCL2, P2RX7, B2M
42	inflammatory response	GO:006954	INF	KIT, SELP, BMP6, S100A12, S100A8, S100A9
43	negative regulation of apoptotic process	GO:043066	INF	SERPINE1, VEGFA, CLU, BCL2, CD44, MIF
44	cytokine-mediated signaling pathway	GO:019221	INF	KIT, VCAM1, B2M, CD44, IL1B, IL6
45	signal transduction	GO:007165	INF	KIT, KITLG, RAP1A, RARA, SCGB1A1, LALBA
46	complement activation	GO:006956	INF	CLU, CFH, CFHR1, CFP, MBL2, MASP1
47	complement activation, classical pathway	GO:006958	INF	SERPING1, CLU, CFI, CD55, CD46, MBL2
48	positive regulation of ERK1 and ERK2 cascade	GO:070374	INF	SERPINF2, CD44, MIF, FGF2, IL1B, CCR1
49	positive regulation of protein phosphorylation	GO:001934	INF	VEGFA, ITGB3, INSR, IL1B, TNF, CTGF
50	positive regulation of cell migration	GO:030335	INF	VEGFA, LAMB1, ITGB1, FLT1, INS, INSR

Molecular functions related to glomerulonephritis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor binding	GO:005102	11.1	TGFB2, EDN3, LTA, PDGFRB, NOS2, NPPA
2	heparin binding	GO:008201	11.0	CTSG, PF4, C6orf25, ELANE, HBEGF, THBS1
3	integrin binding	GO:005178	11.0	COL4A3, ACTN4, THBS1, THY1, DST, CTGF
4	eukaryotic cell surface binding	GO:043499	10.8	ADIPOQ, TGFB1, THBS1, HBEGF, PDGFB, MBL2
5	cytokine activity	GO:005125	10.0	ADIPOQ, IFNB1, IFNA2, CCL4, IL6, IL4
6	growth factor activity	GO:008083	10.0	PDGFB, PDGFD, HBEGF, AGT, TYMP, TGFB1
7	protease binding	GO:002020	9.0	MBP, F3, TP53, TNF, TNFRSF1A, ELANE
8	protein binding	GO:005515	7.6	CSF2, TGFB2, TGFB1, DST, THY1, THBS1
9	protein homodimerization activity	GO:042803	INF	DST, HELT, ACTN4, C1QB, PDGFB, NOS2