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Glomerulopathy malady
80 genes, 4 tissues, 713 related diseases, 24 phenotypes, 98 articles, clinical trials.

Summaries for Glomerulopathy

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44Wikipedia, 22MalaCards
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Wikipedia: Glomerulopathy is a set of diseases affecting the glomeruli of the nephron.44 more...

MalaCards: Glomerulopathy, also known as renal glomerular disease, is related to lipoprotein glomerulopathy and lipoid nephrosis. An important gene associated with Glomerulopathy is GFND1 (Glomerulopathy with fibronectin deposits 1), and among its related pathways are Statin Pathway, Pharmacodynamics and ACE Inhibitor Pathway, Pharmacodynamics. The compounds glucose and pravastatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, monocytes and t cells, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions for Glomerulopathy

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7diseasecard, 43UMLS
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glomerulopathy 7
renal glomerular disease 43

Related Diseases for Glomerulopathy

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13GeneCards, 14GeneDecks
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Diseases related to glomerulopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 710)
idRelated DiseaseScoreTop Affiliating Genes
1lipoprotein glomerulopathy35.3LDLR, LCAT, APOB, APOE, ALB
2lipoid nephrosis28.0NAGLU, CD79A, CD2AP, CCL2, ALB, NPHS1
3protein s deficiency27.8LDLR, IL2RA, APOB, APOE, F5, ALB
4hepatitis27.3SELP, GZMB, ALB, CR1, TGFB1
5focal segmental glomerulosclerosis27.2NAGLU, CD79A, CD2AP, ALB, TRPC6, WT1
6familial mediterranean fever27.0SELP, LEP, MEFV, IL2RA, ALB, ACE
7immunodeficiency25.2BMP6, LGALS1, CD79A, CD40LG, CD40, GZMB
8hemolytic-uremic syndrome24.3VWF, SELP, CFH, CFHR5, CD79A, CD40LG
9amyloidosis24.1VWF, LCAT, CD79A, CD40LG, CD40, MME
10lupus nephritis23.2VWF, SELE, NAGLU, BMP6, CD79A, CD40LG
11obesity, association with22.9VWF, LEP, LEPR, LDLR, INS, APOB
12type 2 diabetes mellitus21.6VWF, SELE, SELP, NAGLU, LEP, LEPR
13nephrotic syndrome21.2LRP2, REN, VWF, SELE, SELP, NAGLU
14nephritis20.6LRP2, REN, VWF, SELE, SELP, NAGLU
15proteinuria19.5LRP2, REN, VWF, SELP, NAGLU, BMP6
16diabetes mellitus17.8REN, VWF, SELE, SELP, NAGA, NAGLU
17thrombosis17.7REN, VWF, SELE, SELP, UTRN, LGALS1
18obesity17.7REN, VWF, SELE, SELP, BMP6, LEP
19glomerulonephritis17.1LRP2, REN, VWF, SELP, NAGA, NAGLU
20nephropathy16.4LRP2, REN, VWF, SELE, SELP, NAGA
21fibrosis15.5REN, VWF, SELE, SELP, NAGA, NAGLU
22cholesterol15.1LRP2, REN, VWF, SELE, SELP, NAGLU
23neuronitis14.3LRP2, REN, VWF, SELE, SELP, VAMP1
24defective apolipoprotein b-10014.0LDLR, LCAT, APOB, APOE
25cetp deficiency14.0LDLR, LCAT, APOB, APOE
26norum disease14.0LCAT, APOB, APOE
27familial hypercholesterolemia13.9LDLR, LCAT, APOB, APOE
28cherubism13.9LDLR, LCAT, MEFV, APOB
29abetalipoproteinemia13.9LGALS1, LDLR, LCAT, APOB, APOE
30age-related maculopathy13.8CFH, APOB, APOE
31membranoproliferative glomerulonephritis type 213.8CFH, CFHR5, APOE
32cryofibrinogenemia13.8CD79A, CD40LG, FN1
33hyperlipidemia type 313.8LDLR, APOB, APOE
34secondary syphilis13.8CD79A, CD40LG, FN1
35hypersensitivity reaction type iii disease13.8ALB, CR1, C3
36chronic pyelonephritis13.7NAGLU, CD79A, ALB
37iritis13.7CD79A, CD40LG, SRP72
38autoimmune disease of central nervous system13.7CD79A, CD40LG, C3
39henoch-schoenlein purpura13.7CD79A, MEFV, ICAM1
40hyperalphalipoproteinemia13.7LDLR, LCAT, APOB
41immunodeficiency with hyper igm13.7CD79A, CD40LG, CD40
42wilson disease13.7NAGLU, CD79A, APOE, ANPEP, ALB
43atypical hemolytic-uremic syndrome13.7CFH, CD46, C3
44hypoalphalipoproteinemia13.7LDLR, LCAT, APOB, ACE
45west nile virus13.6CFH, MSBP1, CD40LG, ANPEP, ALB
46congenital nephrotic syndrome finnish type13.6CD2AP, WT1, ACTN4, NPHS1
47immunodeficiency with hyper igm type 113.6CD79A, CD40LG, CD40
48alport syndrome13.6CD79A, COL4A5, MYH9
49guillain-barre syndrome13.6CD79A, CD40LG, FCGR2A, APOE, CR1
50mayer-rokitansky-kuster-hauser syndrome13.6LDLR, LCAT, MTM1, MEFV, APOB, COL4A5

Graphical network of the top 20 diseases related to glomerulopathy:



Graphical network of diseases related to glomerulopathy

Clinical Features for Glomerulopathy

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Drugs & Therapeutics for Glomerulopathy

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Genetic Tests for Glomerulopathy

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Anatomical Context for Glomerulopathy

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22MalaCards
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MalaCards organs/tissues related to glomerulopathy:

22
Kidney, Monocytes, T cells, Endothelial

Phenotypes for genes affiliated with Glomerulopathy

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25MGI
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MGI Mouse Phenotypes related to glomerulopathy:

25 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539710.3MYH9, ICOS, MEFV, GZMB, CD2AP, UCHL1
2endocrine/exocrine gland phenotypeMP:00053799.7DPP4, CD40LG, LDLR, WT1, LRP2
3integument phenotypeMP:00107719.4LEPR, LGALS1, SELP, ANGPTL2, F5, MME
4respiratory system phenotypeMP:00053889.3LRP2, SELP, UTRN, LEPR, INSR, MTM1
5liver/biliary system phenotypeMP:00053709.1C3, AGT, FABP3, APOB, MET, MEFV
6other phenotypeMP:00053959.0PTGS1, CXCR3, C3, LEPR, PTGS2, ENTPD1
7immune system phenotypeMP:00053878.3ENPP1, MEFV, GZMB, FN1, MME, CD2AP
8nervous system phenotypeMP:00036317.5F5, ENTPD1, INSR, INS, LDLR, NAGLU
9no phenotypic analysisMP:00030127.3MTM1, CD79A, ICOS, MYH9, PPARG, GHRL
10reproductive system phenotypeMP:00053897.3MTM1, CD46, C3, MEFV, ANPEP, CCL2
11skeleton phenotypeMP:00053906.8THBS1, C3, COL1A2, PTGS2, ENPP1, MEFV
12renal/urinary system phenotypeMP:00053676.7MYH9, LCAT, UCHL1, LEPR, UTRN, NAGLU
13digestive/alimentary phenotypeMP:00053816.3LEPR, ICOS, GHRL, PTGS1, THBS1, TGFB1
14tumorigenesisMP:00020066.2TGFB1, THBS1, ACE, PPARG, CCL2, MET
15normal phenotypeMP:00028736.2GHRL, PTGS2, PPARG, ALB, MET, MEFV
16adipose tissue phenotypeMP:00053755.9AGT, TGFB1, SLC2A4, C3, LEPR, LEP
17muscle phenotypeMP:00053695.8PTGS1, PTGS2, TRPC6, ICAM1, CCL2, ENTPD1
18vision/eye phenotypeMP:00053915.4PPARG, PTGS2, TRPC6, THBS1, TGFB1, C3
19growth/size phenotypeMP:00053785.4MYH9, EPHB4, EPHB2, SLC2A4, DPP4, THBS1
20behavior/neurological phenotypeMP:00053865.1NAGLU, SELP, SELE, PPARG, LRP2, AKR1B1
21mortality/agingMP:00107684.7CXCR3, AGTR1, AGT, AGRN, ACTN4, ACE
22cellular phenotypeMP:00053843.1INS, LEPR, APOE, ANGPTL2, CCL2, ICAM1
23cardiovascular system phenotypeMP:00053852.7ENTPD1, ANPEP, CCL2, F5, ICAM1, TRPC6
24homeostasis/metabolism phenotypeMP:00053761.4NPHS1, CXCR3, DPP4, TGFB1, THBS1, AGTR1

Publications for genes affiliated with Glomerulopathy

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35PubMed
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Articles related to glomerulopathy:

(show top 50)    (show all 98)
idTitleAuthorsYearAffiliating Genes
1Novel X-linked glomerulopathy is associated with a CO L4A5 missense mutation in a non-collagenous interruption. (20881942)Becknell B.... Schwaderer A.L.2011COL4A5
2Alpha-actinin-4 and CLP36 protein deficiencies contri bute to podocyte defects in multiple human glomerulopathies. (21680739)Liu Z.... Wu C.2011ACTN4, PDLIM1
3Dendrin location in podocytes is associated with dise ase progression in animal and human glomerulopathy. (21606645)Asanuma K.... Tomino Y.2011DDN
4Interstitial expression of angiotensin II and AT1 rec eptor are increased in patients with progressive glomerulopathies. (20478903)Bahiense-Oliveira M.... Woronik V.2010AGTR1, AGT
5Membranous glomerulopathy: the evolving story. (20110811)Ronco P.... Debiec H.2010MME
6Genetics of focal segmental glomerulosclerosis and hu man immunodeficiency virus-associated collapsing glomerulopathy: the role of MY H9 genetic variation. (20347641)Winkler C.A.... Kopp J.B.2010MYH9
7Common apolipoprotein e gene mutations contribute to lipoprotein glomerulopathy in China. (20090368)Han J.... Wang H.2010APOE
8Non-immunologic mechanisms of calcineurin inhibitors explain its antiproteinuric effects in genetic glomerulopathies. (20195644)Bensman A.... Niaudet P.2010WT1
9Genetical, histological, and clinical characteristics of IgA-negative mesangioproliferative glomerulopathy. (19937361)Owada K.... Watanabe T.2010ACE
10Lipoprotein glomerulopathy treated with LDL-apheresis (Heparin-induced Extracorporeal Lipoprotein Precipitation system): a case repo rt. (20062740)Russi G.... Albertazzi A.2009APOE
11Lipoprotein glomerulopathy induced by ApoE-Sendai is different from glomerular lesions in aged apoE-deficient mice. (19459027)Ishimura A.... Saito T.2009APOE
12Mutations in FN1 cause glomerulopathy with fibronectin deposits. (18268355)Castelletti F.... Noris M.2008FN1
13Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. (18220694)Ziyadeh F.N.... Wolf G.2008TGFB1, NPHS1
14Rituximab treatment of collapsing C1q glomerulopathy: clinical and histopathological evolution. (18351394)Bitzan M.... Bernard C.2008INS
15Glomerular expression of plasmalemmal vesicle-associated protein-1 in patients with transplant glomerulopathy. (17617859)Yamamoto I.... Yamaguchi Y.2007VAMP1, PLVAP
16Analysis of renal immunoexpression of cyclooxygenase-1 and cyclooxygenase-2 in lupus and nonlupus membranous glomerulopathy. (18459455)Danilewicz M.... Wagrowska-Danilewicz M.2007PTGS1, PTGS2
17Pattern of double glomerulopathy in children. (17109138)Cheong H.I.... Choi Y.2007CD79A
18In situ glomerular expression of activated NF-kappaB in human lupus nephritis and other non-proliferative proteinuric glomerulopathy. (16205945)Zheng L.... Hsu S.I.2006CD40, SYNPO
19Immunoexpression of podocyte-associated proteins in acquired human glomerulopathies with nephrotic syndrome. (16739878)Wagrowska-Danilewicz M.... Danilewicz M.2006ACTN4, CD2AP
20Polymorphism of the FcgammaRIIalpha IgG receptor in patients with lupus nephritis and glomerulopathy. (16511922)Gelmetti A.P.... Monteiro R.C.2006FCGR2A
21Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. (16210374)Wu Y.... Li L.2006PPARG, FABP3, LEPR
22Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts. (16049072)Shimizu A.... Colvin R.B.2005ENTPD1
23The kd/kd mouse is a model of collapsing glomerulopathy. (16120817)Barisoni L.... Nelson P.J.2005SYNPO
24Impact of HLA antibodies on transplant glomerulopathy . (16386554)Palomar R.... Arias M.2005MTM1
25Clinical and pathological analyses of lipoprotein glomerulopathy (15181857)Hu Z.X.... Huang S.M.2004ALB
26A novel in vivo lecithin-cholesterol acyltransferase (LCAT)-deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy. (15466392)Zhu X.... Ng D.S.2004LCAT
27Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies. (15213271)Masaki T.... Nikolic-Paterson D.J.2004EPHB2
28Conformational transitions and glycation of serum albumin in patients with minimal-change glomerulopathy. (15481604)Hong S.Y.... Cheong C.J.2004ALB
29Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy. (12919091)Akalin E.... Hancock W.W.2003CXCR3, ICOS
30EphB4 receptor tyrosine kinase transgenic mice develo p glomerulopathies reminiscent of aglomerular vascular shunts. (12676328)Andres A.C.... Ziemiecki A.2003EPHB4
31Familial Mediterranean fever, inflammation and nephrotic syndrome: fibrillary glomerulopathy and the M680I missense mutation. (12908875)Fisher P.W.... Rutecki G.W.2003MEFV
32A patient with apolipoprotein E2 variant (Q187E) with out lipoprotein glomerulopathy. (11877595)Hayakawa M.... Yamada A.2002APOE
33Interaction of endothelial cells and triglyceride-ric h lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipopro tein glomerulopathy. (11833049)Murano T.... Shirai K.2002APOE
34The angiotensin-converting enzyme DD genotype is associated with glomerulopathy lesions in type 2 diabetes. (11756350)Solini A.... Fioretto P.2002ACE
35Evidence of a threshold value of glycated hemoglobin to improve the course of renal function in type 2 diabetes with typical diabetic glomerulopathy. (11783602)Brocco E.... Nosadini R.2001ALB
36Use of complement receptor 1 (CD35) assay in the diagnosis and prognosis of immune complex mediated glomerulopathies. (11495296)Raju K.R.... Srivastava L.M.2001CR1
37Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. (10903326)Ishigaki Y.... Yamamoto T.T.2000APOE
38Expression of agrin, dystroglycan, and utrophin in normal renal tissue and in experimental glomerulopathies. (10793086)Raats C.J.... Berden J.H.2000AGRN, UTRN
39Molecular cloning of the critical region for glomerulopathy with fibronectin deposits (GFND) and evaluation of candidate genes. (10964510)Vollmer M.... Hildebrandt F.2000SRP72
40Evidence that microdeletions in the alpha globin gene protect against the development of sickle cell glomerulopathy in humans. (10232687)Guasch A.... Elsas L.J.1999ALB
41Melatonin and taurine reduce early glomerulopathy in diabetic rats. (10232838)Ha H.... Kim K.H.1999TGFB1
42Origin of hyperplastic epithelial cells in idiopathic collapsing glomerulopathy. (10383699)Kihara I.... Yanagihara T.1999SYNPO
43A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy. (10432380)Matsunaga A.... Doi T.1999APOE
44Association of a novel 3-amino acid deletion mutation of apolipoprotein E (Apo E Tokyo) with lipoprotein glomerulopathy. (10529627)Konishi K.... Sasaki J.1999APOE
45Association of apolipoprotein E polymorphism with lipoprotein glomerulopathy. Report of 2 cases with a new genotype and comparison of the relative frequencies of apolipoprotein E isoforms in lipoprotein glomerulopathy and in the general population. (9546684)Yang A.H.... Kao J.T.1998APOE
46Lipoprotein glomerulopathy: a new French case with recurrence on the transplant (8762276)Djamali A.... Mourad G.1996APOE
47Combination of glomerulonephritis with diabetic glomerulopathy in a patient with diabetes mellitus due to autoantibody to insulin receptor. (8107939)Ishimura E.... Morii H.1994INSR
48Lipoprotein glomerulopathy: first report in a Chinese male. (7985674)Zhang P.... Gallo G.1994APOE
49Lipoprotein glomerulopathy. Report of a normolipidemic case and review of the literature. (8322843)Saito T.... Sakaguchi H.1993APOE
50Effects of converting-enzyme inhibition on barrier fu nction in diabetic glomerulopathy. (1698674)Morelli E.... Myers B.D.1990ALB, REN

Expression for genes affiliated with Glomerulopathy

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Glomerulopathy

Pathways for genes affiliated with Glomerulopathy

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34PharmGKB, 41Thomson Reuters, 3Cell Signaling Technology, 10EMD Millipore, 38Reactome, 20KEGG, 36QIAGEN, 37R&D Systems
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Pathways related to glomerulopathy according to GeneDecks:

(show all 39)
idPathwayScoreTop Affiliating Genes
1Statin Pathway, Pharmacodynamics3410.7LCAT, APOB, APOE, LDLR
2ACE Inhibitor Pathway, Pharmacodynamics3410.7AGTR1, MME
3Cell adhesion_Endothelial cell contacts by non-junctional mechanisms4110.4COL4A5, COL1A2, ACTN4, FN1
4Immune response_Lectin induced complement pathway4110.4C4BPA, CR1, CD46
5Lymphocyte Signaling310.4IL2RA, MME, LGALS1
6Cell adhesion Endothelial cell contacts by non-junctional mechanisms1010.3COL1A2, COL4A5, FN1, ACTN4
7Immune response Lectin Induced complement pathway1010.3C3, CR1, CD46, C4BPA
8Complement cascade3810.3CFH, CR1, C4BPA, CD46
9Immune response_Alternative complement pathway4110.2CFH, CD46, C3, CR1
10Immune response Alternative complement pathway1010.2CD46, C3, CR1, CFH
11Cell adhesion molecules (CAMs)2010.2ICOS, SELP, CD40
12ECM-receptor interaction2010.2VWF, FN1, COL4A5, AGRN, THBS1, COL1A2
13Staphylococcus aureus infection2010.1C3, CFH, ICAM1, SELP, FCGR2A
14PGC1Alpha Pathway3610.1BMP6, SLC2A4, INSR
15Endothelin-1 Signaling Pathway3610.1BMP6, INSR, EPHB2, EPHB4
16Cell adhesion Integrin-mediated cell adhesion and migration1010.1COL4A5, MYH9, COL1A2, ACTN4, FN1
17Cell adhesion_Integrin-mediated cell adhesion and migration4110.1FN1, COL4A5, ACTN4, COL1A2, MYH9
18Renin-angiotensin system209.9AGT, MME, ANPEP, REN, ACE, AGTR1
19Focal adhesion209.9MET, FN1, COL4A5, COL1A2, ACTN4, VWF
20Akt Signaling369.7SLC2A4, CXCR3, MET, IL2RA, EPHB2, CCL2
21Complement and coagulation cascades209.6C3, F5, CR1, C4BPA, CD46, CFH
22Metabolism of lipids and lipoproteins389.6LRP2, APOB, MTM1, LCAT, APOE, AKR1B1
23Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics349.5REN, ACE, AGT, AGTR1, TGFB1, MME
24Selected targets of HNF1109.5ALB, DPP4, APOB, INS
25Leishmaniasis209.4TGFB1, CR1, C3, PTGS2, FCGR2A
26JNK Pathway369.4BMP6, IL2RA, TGFB1
27ILK Signaling369.3MYH9, COL4A5, PTGS2, MET, INSR, COL1A2
28NFAT in Immune Response369.2FCGR2A, MET, INSR, CD79A, BMP6, TGFB1
29Molecular Mechanisms of Cancer369.2TGFB1, COL4A5, MET, INSR, FN1, BMP6
30ERK Signaling369.1EPHB4, INSR, COL4A5, FN1, EPHB2, BMP6
31Adipocytokines & Insulin Signaling379.0SLC2A4, ANGPTL2, INSR, INS, LEP
32Phospholipase-C Pathway369.0FN1, TGFB1, COL1A2, COL4A5, IL2RA, FCGR2A
33MAPK Signaling369.0COL1A2, COL4A5, IL2RA, MET, INSR, FN1
34Rho Family GTPases368.8COL1A2, EPHB4, TGFB1, CCL2, EPHB2, BMP6
35JAK-STAT Pathway368.6CCL2, EPHB2, TGFB1, BMP6, INSR, MET
36Malaria208.5SELP, TGFB1, THBS1, CR1, ICAM1, CCL2
37Cytokine-cytokine receptor interaction208.1LEP, LEPR, CD40LG, CD40, MET, IL2RA
38p38 Signaling368.1MET, CCL2, IL2RA, CXCR3, EPHB2, EPHB4
39Renin-Angiotensin Pathway367.9REN, IL2RA, CCL2, PTGS2, AGTR1, ACE

Compounds for genes affiliated with Glomerulopathy

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32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to glomerulopathy according to GeneDecks:

(show top 50)    (show all 365)
idCompoundScoreTop Affiliating Genes
1glucose32 10.5NAGA, VAMP1, LGALS1, MME, GZMB, AGRN
2pravastatin32 34 9 18 9 14.0SELE, SELP, LDLR, LCAT, APOB, APOE
3carbohydrates32 9.8SELE, SELP, NAGA, LGALS1, LDLR, RPS27A
4hyaluronic acid32 18 10.3BMP6, CFH, FN1, GZMB, PTGS1, WT1
5pge232 9.3REN, SELE, LDLR, MME, FN1, AKR1B1
6n acetylcysteine32 9.2VWF, SELE, SELP, NAGLU, CD79A, CD40
7rapamycin32 42 10.0LGALS1, LDLR, CD46, FN1, GZMB, INS
8testosterone32 9 18 9 11.9SELE, LCAT, CD79A, CD40LG, MME, INSR
9heparin32 9 18 9 11.4LRP2, VWF, LGALS1, LCAT, CFH, CD79A
10cysteine32 8.0SELP, NAGLU, LGALS1, LEPR, LDLR, UCHL1
11h2o232 7.8VWF, NAGLU, LEP, LEPR, LDLR, CD79A
12ly29400232 7.8SELE, LEP, FN1, GZMB, FCGR2A, CCL2
13candesartan32 9 9 9.7REN, SELP, CCL2, ALB, PTGS1, PPARG
14pioglitazone32 9 9 9.5LEP, CD40, FN1, INS, INSR, APOB
15simvastatin32 34 42 9 18 9 12.5VWF, SELE, SELP, BMP6, LDLR, LCAT
16glutamine32 7.2VWF, BMP6, LGALS1, LEPR, LDLR, LCAT
17fenofibrate32 9 9 9.2SELE, SELP, LEP, LDLR, CD40LG, CD40
18epinephrine32 9 18 9 10.1REN, SELE, SELP, BMP6, LEP, CD79A
19actinomycin d32 7.1SELE, LDLR, CD40LG, CD40, MME, FN1
20genistein32 9 18 9 10.0SELE, SELP, LDLR, CD40LG, CD40, FN1
21atorvastatin32 34 9 18 9 11.0VWF, SELE, SELP, BMP6, LDLR, LCAT
22tacrolimus32 34 9 9 9.9REN, NAGLU, BMP6, CFH, CD79A, CD40
23estrogen32 6.9VWF, LEP, LEPR, LCAT, GZMB, INS
24rosiglitazone32 9 18 9 9.8SELE, LEP, INS, INSR, APOB, APOE
25fibrinogen32 6.7SELE, SELP, LEP, CFH, CD79A, CD40LG
26vitamin d32 6.7LRP2, NAGLU, BMP6, LEPR, LDLR, CD79A
27aspirin32 34 18 8.6VWF, SELE, SELP, BMP6, LDLR, CD79A
28metformin32 34 9 9 9.6VWF, LEP, INS, INSR, APOB, ENPP1
29paraffin32 6.6VWF, LGALS1, LEP, CD79A, CD40LG, CD40
30alanine32 6.5VWF, SELE, NAGLU, BMP6, LEPR, LDLR
31thyroxine32 18 7.5LRP2, REN, VWF, LEP, LEPR, LDLR
32losartan32 34 9 9 9.4REN, VWF, SELE, SELP, NAGLU, BMP6
33polysaccharide32 6.3SELE, SELP, BMP6, LGALS1, CFH, CD79A
34troglitazone32 42 9 9 9.2SELE, BMP6, LEP, LDLR, FN1, INS
35norepinephrine32 9 18 9 9.1REN, VWF, SELE, SELP, BMP6, LEP
36arginine32 6.1REN, VWF, UTRN, LGALS1, LEP, LEPR
37indomethacin32 9 9 8.1REN, BMP6, LGALS1, LEP, LDLR, CD79A
38cyclosporin a32 42 7.1VWF, SELP, NAGLU, BMP6, LEP, LDLR
39retinoic acid32 42 18 7.8LRP2, VWF, SELP, BMP6, LDLR, CFH
40phosphatidylinositol32 5.7BMP6, LEP, LEPR, MTM1, CD40, CD46
41prostacyclin32 5.6REN, VWF, SELE, SELP, BMP6, LEP
42cycloheximide32 5.4SELE, BMP6, LEP, LDLR, CD40, CD46
43vegf32 5.2REN, VWF, SELE, SELP, LEPR, CD40LG
44creatinine32 5.1REN, VWF, SELE, SELP, NAGLU, BMP6
45nitric oxide32 9 18 9 8.0LRP2, REN, VWF, SELE, SELP, NAGLU
46lipid32 4.8LRP2, SELE, NAGLU, LGALS1, LEP, LEPR
47tyrosine32 4.6VWF, SELP, BMP6, UTRN, LGALS1, LEPR
48cholesterol32 9 18 9 7.3LRP2, REN, VWF, SELE, SELP, NAGLU
49dexamethasone32 42 34 9 9 7.0REN, VWF, SELP, BMP6, LGALS1, LEP
50serine32 2.9LRP2, VWF, SELE, BMP6, LGALS1, LEP

GO Terms for genes affiliated with Glomerulopathy

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12Gene Ontology
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Cellular components related to glomerulopathy according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particleGO:03436210.4LDLR, APOB, APOE
2basal laminaGO:00560510.2COL4A5, ENTPD1, AGRN
3extracellular matrixGO:0310129.8THBS1, AGRN, COL1A2, FN1, LGALS1, VWF
4cell surfaceGO:0099869.3CR1, EPHB4, DPP4, ENPP1, CD46, LDLR
5platelet alpha granule lumenGO:0310939.3VWF, ACTN4, ALB, F5, TGFB1, FN1
6external side of plasma membraneGO:0098978.5CXCR3, THBS1, ACE, ICOS, ICAM1, ANPEP
7endoplasmic reticulum lumenGO:0057888.4COL1A2, COL4A5, GHRL, APOB, INS, PTGS2
8integral to plasma membraneGO:0058878.2CR1, AGTR1, CXCR3, NPHS1, SLC2A4, EPHB4
9extracellular regionGO:0055765.8AGT, C4BPA, COL1A2, COL4A5, APOB, GHRL
10plasma membraneGO:0058865.3CD40LG, CD2AP, CD40, CD46, MME, INSR
11extracellular spaceGO:0056154.8AGT, FN1, CD40LG, CFH, LCAT, LEP

Biological processes related to glomerulopathy according to GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:04215710.7APOB, LDLR, LCAT, APOE, ALB
2cholesterol transportGO:03030110.5LDLR, LCAT, APOB
3positive regulation of cholesterol esterificationGO:01087310.5AGT, AGTR1, APOE
4renin-angiotensin regulation of aldosterone productionGO:00201810.4AGT, AGTR1, REN
5low-density lipoprotein particle remodelingGO:03437410.4APOB, AGT, AGTR1
6regulation of complement activationGO:03044910.2CFH, CR1, CD46, C4BPA, C3
7complement activation, alternative pathwayGO:00695710.2CFH, CFHR5, C3
8positive regulation of macrophage derived foam cell differentiationGO:01074410.2AGTR1, AGT, APOB
9leukocyte migrationGO:05090010.2SELP, FN1, APOB, ICAM1, COL1A2, MYH9
10B cell proliferationGO:04210010.0CD79A, CD40LG, CD40
11leukocyte cell-cell adhesionGO:00715910.0SELE, ICAM1, SELP, CD40LG
12cholesterol metabolic processGO:0082039.9LEP, LEPR, LDLR, LCAT, APOB, APOE
13angiogenesisGO:0015259.9FN1, EPHB2, ANPEP, CCL2, MYH9, CXCR3
14lipid metabolic processGO:0066299.8PPARG, LRP2, LDLR, LCAT, ALB, APOE
15negative regulation of blood vessel endothelial cell migrationGO:0435379.8THBS1, APOE, TGFB1
16leukocyte tethering or rollingGO:0509019.8SELE, LEP, SELP
17activation of MAPK activityGO:0001879.7MET, INSR, GHRL, RPS27A, THBS1
18regulation of vasoconstrictionGO:0192299.5AGTR1, AGT, ACE
19kidney developmentGO:0018229.5AGT, REN, MME, WT1, ACE, BMP6
20platelet degranulationGO:0025769.5SELP, FN1, F5, TGFB1, ALB, ACTN4
21response to vitamin DGO:0332809.4PTGS2, INSR, LRP2, TGFB1
22cellular response to organic cyclic compoundGO:0714079.3TGFB1, PPARG, CCL2, LGALS1
23positive regulation of cellular protein metabolic processGO:0322709.3TGFB1, AGTR1, AGT, INS
24blood coagulationGO:0075969.2ACTN4, TGFB1, THBS1, SELP, COL1A2, APOB
25agingGO:0075689.1TGFB1, AGT, PTGS1, CCL2, LRP2
26placenta developmentGO:0018909.1VWF, PPARG, LEP, MET
27positive regulation of nitric oxide biosynthetic processGO:0454299.0PTGS2, ICAM1, INSR, INS
28cell adhesionGO:0071559.0CCL2, ENTPD1, THBS1, VWF, F5, ICAM1
29response to hypoxiaGO:0016669.0DPP4, LEP, THBS1, ACTN4, PDLIM1, CCL2
30G-protein coupled receptor signaling pathwayGO:0071868.8C3, AGT, CCL2, GHRL, ENTPD1, APOE
31positive regulation of NF-kappaB transcription factor activityGO:0510928.8INS, RPS27A, TGFB1, AGT, ICAM1, CD40
32platelet activationGO:0301688.7TRPC6, CD40LG, THBS1, CD40, FN1, ENTPD1
33regulation of blood pressureGO:0082178.5PTGS1, PTGS2, LEP, ACE, REN, COL1A2
34small molecule metabolic processGO:0442818.3NAGLU, LRP2, LCAT, MTM1, APOB, APOE
35inflammatory responseGO:0069548.1BMP6, SELP, CD40LG, CD40, CCL2, MEFV
36response to drugGO:0424937.9PTGS2, LRP2, TGFB1, THBS1, LGALS1, PPARG

Molecular functions related to glomerulopathy according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.8SELP, LGALS1, LDLR, THBS1, VWF
2heparin bindingGO:0082019.5SELP, THBS1, CCL2, APOE, APOB, FN1
3insulin-like growth factor receptor bindingGO:0051599.3INSR, INS, REN
4protein homodimerization activityGO:0428038.4VWF, LGALS1, APOE, ENPP1, PTGS2, PLVAP
5protein bindingGO:0055153.8MYH9, WT1, COL1A2, PPARG, DDN, TRPC6

Sources for Glomerulopathy

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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