Glomerulosclerosis malady

Wikipedia: Glomerulosclerosis refers to a hardening of the glomerulus in the kidney. It is a general term to...⁴⁴ more...

MalaCards: Glomerulosclerosis, also known as glomerulosclerosis (disorder), is related to focal segmental glomerulosclerosis and focal glomerulosclerosis. An important gene associated with Glomerulosclerosis is ACTN4 (actinin, alpha 4), and among its related pathways are Cell adhesion_ECM remodeling and Cell adhesion ECM remodeling. The compounds cholesterol and glutamine have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and t cells, and related mouse phenotypes are cellular and hematopoietic system.

glomerulosclerosis 7 32 glomerulosclerosis (disorder) 43

Diseases related to glomerulosclerosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 978)

id	Related Disease	Score	Top Affiliating Genes
1	focal segmental glomerulosclerosis	38.1	VTN, RBP4, NAGLU, PAX2, CD79A, CD2AP
2	focal glomerulosclerosis	33.7	REN, VLDLR, LPL, CLCN5, FABP1, ALB
3	hypertension	30.1	REN, NOS2, ACE, AGT, AGTR1
4	denys-drash syndrome	28.9	PAX2, CD2AP, WT1, TGFB1, NPHS1, NPHS2
5	frasier syndrome	28.8	CD2AP, WT1, ACTN4, NPHS2
6	renovascular hypertension	28.6	REN, ACE, AGTR1
7	nephrosis	28.4	LPL, LAMB1, LAMB2, IL10, IL6, APOB
8	hepatitis	28.2	RBP4, IFNA1, IFNA2, ALB, SMAD3, TIMP2
9	familial hypercholesterolemia	27.5	COG2, LPA, LPL, LCAT, APOB, APOE
10	epidermolysis bullosa	27.2	VIM, LAMB1, LAMC1, CD79A, CD36, ITGB4
11	hematuria	27.0	NAGLU, CD79A, CD40LG, FN1, INS, COL4A3
12	nephrosclerosis	26.7	SERPINE1, LPA, BMP7, LCAT, MTHFR, INS
13	hepatitis c	26.5	CD40LG, IL10, IL2, IFNA1, IFNA2, IFNG
14	diphtheria	26.4	CD79A, CD40LG, IL2, IL2RA, IFNG, ALB
15	wilms tumor	25.9	REN, VIM, BMP6, PAX2, MTHFR, CD36
16	proteinuria	25.7	COG2, REN, VTN, RBP4, SERPINE1, NAGLU
17	hyperlipidemia	25.7	COG2, RBP4, SERPINE1, VLDLR, LPA, LPL
18	glomerulopathy	25.6	REN, NAGLU, BMP6, LCAT, CD79A, CD40LG
19	immunodeficiency	25.1	BMP6, CD79A, CD40LG, MIF, INS, IL10
20	nephrotic syndrome	25.0	REN, VTN, RBP4, SERPINE1, VIM, NAGLU
21	thrombocytopenia	24.1	SERPINE1, BMP6, MTHFR, CD79A, CD36, CD40LG
22	hypercholesterolemia	23.2	COG2, RBP4, SERPINE1, LPA, LPL, CHKA
23	glomerulonephritis	21.8	REN, VTN, RBP4, SERPINE1, VIM, NAGLU
24	blindness	21.3	COG2, REN, RBP4, SERPINE1, LPL, CLCN5
25	fibrosis	21.2	REN, VTN, RBP4, SERPINE1, VIM, NAGLU
26	nephropathy	21.1	COG2, REN, VTN, RBP4, SERPINE1, NAGLU
27	atherosclerosis	17.4	COG2, REN, VTN, RBP4, SERPINE1, VLDLR
28	diabetes mellitus	17.0	COG2, REN, VTN, RBP4, SERPINE1, NAGLU
29	cholesterol	16.8	COG2, REN, VTN, RBP4, SERPINE1, VLDLR
30	leukemia	15.7	COG2, REN, VTN, RBP4, SERPINE1, VIM
31	malignant hypertension	14.2	REN, TRPC6, EDN1, ACE, AGT, AGTR1
32	anuria	14.1	REN, ALB, ACE, AGT, AGTR1
33	renal tubular dysgenesis	14.1	REN, ACE, AGT, AGTR1
34	renal vascular disease	14.1	MPV17, ALB, CTGF, ACE
35	posterior urethral valves	14.1	ACE, AGT, AGTR1, TGFB1
36	diffuse mesangial sclerosis	14.1	PAX2, LAMB2, PLCE1, WT1
37	orthostatic hypotension	14.1	REN, ALB, ACE, AGT, AGTR1
38	aortic coarctation	14.1	EDN1, ACE, AGT, AGTR1
39	oligohydramnios	14.1	REN, NAGLU, EDN1, ACE, AGT, AGTR1
40	fibromuscular dysplasia	14.1	REN, ACE, AGT, AGTR1
41	postural orthostatic tachycardia syndrome	14.1	REN, NOS2, AGT, AGTR1
42	nephrogenic systemic fibrosis	14.0	CTGF, SMAD2, SMAD3, TGFB1
43	alport syndrome	14.0	CD79A, COL4A3, COL4A4, MYH9
44	chronic rapidly progressive glomerulonephritis	14.0	SERPINE1, NAGLU, CD79A, FN1, FABP1, ALB
45	diastolic heart failure	14.0	BMP6, MMP2, ACE, AGT, AGTR1
46	nail-patella syndrome	14.0	PAX2, CD2AP, COL4A4, NPHS2
47	eisenmenger syndrome	14.0	EDN1, ACE, THBD, TGFB1
48	nephroblastoma	14.0	REN, VIM, PAX2, CDKN1C, PTPRC, CTGF
49	familial nephrotic syndrome	14.0	LAMB2, PLCE1, NPHS1
50	ocular cicatricial pemphigoid	14.0	CD79A, ITGB4, MIF, TNF, CTGF, TGFB1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to glomerulosclerosis:

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MGI Mouse Phenotypes related to glomerulosclerosis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	INF	SMAD3, SMAD2, SMAD1, NRF1, CTGF, SRC
2	hematopoietic system phenotype	MP:0005397	INF	SLC12A1, PTPRC, , FGF2, , CD2AP
3	immune system phenotype	MP:0005387	INF	FN1, VIM, REN, , LMNA, ZMPSTE24
4	mortality/aging	MP:0010768	INF	MYH9, SCARB2, REN, PAX2, PAFAH1B1, ZMPSTE24
5	cardiovascular system phenotype	MP:0005385	INF	GNE, IL2, IL10, FGF2, INS, IRS1
6	vision/eye phenotype	MP:0005391	INF	MTHFR, LCAT, PAX2, BMP7, LMNA,
7	respiratory system phenotype	MP:0005388	10.3	APOE, LAMC1, LPL, PTPRC
8	integument phenotype	MP:0010771	9.4	ZMPSTE24, SMAD2, SRC, TRPC6, IFNG, IGF1R
9	no phenotypic analysis	MP:0003012	9.2	CLCN5, SLC2A1, SMAD2, F2R, INS, FMN1
10	endocrine/exocrine gland phenotype	MP:0005379	8.8	WT1, SMAD1, GIPR, IFNG, IL2, ITGA3
11	other phenotype	MP:0005395	8.8	NOS2, APOE, IL2, FN1, MMP14, ITGB1
12	limbs/digits/tail phenotype	MP:0005371	8.6	IL10, IRS1, MTHFR, CDKN1C, ITGA3, THBS1
13	adipose tissue phenotype	MP:0005375	8.1	INS, IRS1, CD36, MPV17, MTOR, ZMPSTE24
14	liver/biliary system phenotype	MP:0005370	7.5	AGT, MPV17, LCAT, CHKA, CLCN5, ZMPSTE24
15	skeleton phenotype	MP:0005390	INF	SMAD3, SMAD2, SMAD1, CTGF, SRC, PTPRC
16	behavior/neurological phenotype	MP:0005386	INF	COL4A3, IL2, IL10, INS, MMP14, ITGB4
17	embryogenesis phenotype	MP:0005380	INF	TFAM, SRC, , VIM
18	renal/urinary system phenotype	MP:0005367	INF	MYH9, GAPDH, SLC12A1, NPHS2, NPHS1, NPHP4
19	nervous system phenotype	MP:0003631	INF	EDN1, LTBP1, PLAUR, SMAD3, SMAD2, SMAD1
20	tumorigenesis	MP:0002006	INF	IL6, CCL2, IFNG, PTPRC, SRC, SMAD1
21	muscle phenotype	MP:0005369	INF	MMP2, VIM, , REN, LPL, LMNA
22	normal phenotype	MP:0002873	INF	THBD, MYH9, HBEGF, CDKN1C, LAMC1, MTOR
23	digestive/alimentary phenotype	MP:0005381	INF	EDN1, COL4A4, NOS2, SMAD3, SMAD2, SMAD1
24	craniofacial phenotype	MP:0005382	INF	EDN1, SMAD1, LTBP1, SMAD3, IGF1R, CDKN1C
25	reproductive system phenotype	MP:0005389	INF	SLC12A1, NPHP4, TGFB1, THBS1, AGT, WT1
26	hearing/vestibular/ear phenotype	MP:0005377	INF	ITGB1, ITGB4, BMP7, PAX2, SCARB2, MPV17
27	growth/size phenotype	MP:0005378	INF	TFAM, THBS1, THBD, AGTR1, AGT, HBEGF
28	pigmentation phenotype	MP:0001186	INF	APOB, APOE, CCL2, SRC, NPHP4, FMN1
29	homeostasis/metabolism phenotype	MP:0005376	INF	, REN, MTOR, , MYH9, GAPDH

Articles related to glomerulosclerosis:

(show top 50)    (show all 193)

id	Title	Authors	Year	Affiliating Genes
1	Activation of Src mediates PDGF-induced Smad1 phospho rylation and contributes to the progression of glomerulosclerosis in glomerulon ephritis. (21445358)	Mima A.... Doi T.	2011	SRC, SMAD1
2	Arhgap24 inactivates Rac1 in mouse podocytes, and a m utant form is associated with familial focal segmental glomerulosclerosis. (21911940)	Akilesh S.... Shaw A.S.	2011	ARHGAP24
3	Up-regulation of the homophilic adhesion molecule sid ekick-1 in podocytes contributes to glomerulosclerosis. (20562105)	Kaufman L.... Klotman P.E.	2010	MAGI1, SDK1
4	A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. (20668430)	Genovese G.... Pollak M.R.	2010	MYH9
5	CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS). (19131354)	Gigante M.... Gesualdo L.	2009	CD2AP
6	Very low-molecular-mass fragments of albumin in the p lasma of patients with focal segmental glomerulosclerosis. (19781833)	Hellin J.L.... Nieto J.L.	2009	ALB
7	TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. (19129465)	SchlAPndorff J.... Pollak M.R.	2009	TRPC6
8	Angiotensin-converting enzyme gene polymorphism and the progression rate of focal segmental glomerulosclerosis in Iranian children. (19076285)	Gheissari A.... Naeini A.E.	2008	ACE
9	MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. (18794856)	Kopp J.B.... Winkler C.A.	2008	MYH9
10	Therapeutic targets in focal and segmental glomerulosclerosis. (18660675)	Lavin P.J.... Winn M.P.	2008	GNE
11	Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. (17456853)	Sugimoto H.... Kalluri R.	2007	BMP7
12	Recessive NPHS2 (Podocin) mutations are rare in adult-onset idiopathic focal segmental glomerulosclerosis. (17699384)	He N.... Pei Y.	2007	NPHS2
13	Is mesangial hypercellularity with glomerular immaturity a variant of glomerulosclerosis? (17235549)	Ostalska-Nowicka D.... Witt M.	2007	SYNPO
14	High sirolimus levels may induce focal segmental glomerulosclerosis de novo. (17699432)	Letavernier E.... Legendre C.	2007	SYNPO
15	Synaptopodin immunoexpression in steroid-responsive and steroid-resistant minimal change disease and focal segmental glomerulosclerosis (18336100)	Wagrowska-Danilewicz M.... Danilewicz M.	2007	SYNPO
16	Focal segmental glomerulosclerosis in a patient homozygous for a CD2AP mutation. (17713465)	Lowik M.M.... van den Heuvel L.P.	2007	CD2AP
17	Transitions of serum albumin in patients with glomerulosclerosis 'in vivo' characterization by electrophoretic titration curves. (16764009)	Bruschi M.... Ghiggeri G.M.	2006	ALB
18	Reduced podocyte expression of alpha3beta1 integrins and podocyte depletion in patients with primary focal segmental glomerulosclerosis and chronic PAN-treated rats. (16459165)	Chen C.A.... Chen H.C.	2006	ITGB1, ITGA3
19	Posttransplant recurrence of proteinuria in a case of focal segmental glomerulosclerosis associated with WT1 mutation. (16780544)	Ghiggeri G.M.... Gesualdo L.	2006	ALB, WT1, NPHS2
20	Angiotensin converting enzyme inhibition prevents dev elopment of collapsing focal segmental glomerulosclerosis in Thy-1.1 transgenic mice. (16968721)	Smeets B.... Wetzels J.F.	2006	ACE
21	Adenovirus-mediated gene transfer and lipoprotein-mediated protein delivery of plasma PAF-AH ameliorates proteinuria in rat model of glomerulosclerosis. (16213192)	Iso-o N.... Tsukamoto K.	2006	PAFAH1B1
22	Life-threatening thrombocytopenia and nephrotic syndrome due to focal segmental glomerulosclerosis associated with pegylated interferon alpha-2b and ribavirin treatment for hepatitis C. (17105597)	Alves Couto C.... de Abreu Ferrari T.C.	2006	IFNA2
23	Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis. (16564554)	Hirakawa M.... Iida M.	2006	PTPRO, PTPRU, SYNPO
24	Mutational and Biological Analysis of alpha-actinin-4 in focal segmental glomerulosclerosis. (16251236)	Weins A.... Pollak M.R.	2005	ACTN4
25	A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. (15879175)	Winn M.P.... Rosenberg P.B.	2005	TRPC6
26	Racial and ethnic differences in the incidence and progression of focal segmental glomerulosclerosis in children. (14730545)	Andreoli S.P.	2004	ACTN4, NPHS1, NPHS2
27	C5b-9 regulates peritubular myofibroblast accumulatio n in experimental focal segmental glomerulosclerosis. (15496154)	Rangan G.K.... Couser W.G.	2004	VIM
28	Influence of cytokine gene polymorphisms on focal segmental glomerulosclerosis. (15308875)	Bantis C.... Ivens K.	2004	TGFB1, TNF, IL6
29	Glomerular tip lesion: a distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum. (15086908)	Stokes M.B.... D'Agati V.D.	2004	ALB
30	Significance of MMP-2 and TIMP-2 mRNA expressions on glomerular cells in the development of glomerulosclerosis. (15250240)	Zhang Z.G.... Guo M.Y.	2004	MMP2, TIMP2
31	The parietal epithelial cell: a key player in the pathogenesis of focal segmental glomerulosclerosis in Thy-1.1 transgenic mice. (15034095)	Smeets B.... Steenbergen E.J.	2004	SYNPO
32	Clinical, histopathologic, and genetic studies in nine families with focal segmental glomerulosclerosis. (12776268)	Rana K.... Savige J.	2003	ACTN4, NPHS1, NPHS2
33	Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant alpha-actinin-4. (12707390)	Michaud J.L.... Kennedy C.R.	2003	ACTN4
34	Significance of early phenotypic change of glomerular podocytes detected by Pax2 in primary focal segmental glomerulosclerosis. (11877566)	Ohtaka A.... Ito S.	2002	PAX2, CHKA
35	The expressions of TGF-beta1 and Smad 2 mRNA on diseased glomeruli and their significance in the development of glomerulosclerosis (12417087)	Ruan Y.... Guo M.	2002	TGFB1, SMAD2
36	Activated intrarenal transcription of CTL-effectors and TGF-beta1 in children with focal segmental glomerulosclerosis. (11786088)	Strehlau J.... Strom T.B.	2002	TGFB1, IL2RA
37	Apolipoproteins prevent glomerular albumin permeability induced in vitro by serum from patients with focal segmental glomerulosclerosis. (11134260)	Candiano G.... Ghiggeri G.M.	2001	ALB
38	Plasma and urinary endothelin-1 in focal segmental glomerulosclerosis. (11291106)	Chen H.C.... Lai Y.H.	2001	EDN1
39	Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. (10700177)	Kaplan J.M.... Pollak M.R.	2000	ACTN4
40	WT1 splice-site mutations are rarely associated with primary steroid-resistant focal and segmental glomerulosclerosis. (10792605)	Denamur E.... Loirat C.	2000	WT1
41	Interleukin-4 transgenic mice develop glomerulosclerosis independent of immunoglobulin deposition. (11009105)	RA1ger B.M.... Hasan Q.	2000	CD36
42	Glomerulosclerosis in mice transgenic for human insulin-like growth factor-binding protein-1. (10844600)	Doublier S.... Baud L.	2000	IGFBP1
43	Congenital focal segmental glomerulosclerosis associated with beta4 integrin mutation and epidermolysis bullosa. (10873890)	Kambham N.... D'Agati V.D.	2000	ITGB4
44	A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors. (9572571)	McCarty M.F.	1998	BMP6, DGKQ
45	A randomized double-blind placebo-controlled trial of cyclosporine in steroid-resistant idiopathic focal segmental glomerulosclerosis in children. (8808110)	Lieberman K.V.... Tejani A.	1996	ALB
46	Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice by transgenesis with the human Mpv17 homologue. (7564095)	Schenkel J.... Weiher H.	1995	MPV17
47	Recurrent focal segmental glomerulosclerosis in pediatric renal transplant recipients: successful treatment with oral cyclophosphamide. (7865917)	Kershaw D.B.... Bunchman T.E.	1994	ALB
48	Hyperlipidemia and glomerulosclerosis in nephropathies: clinicomorphological comparisons (7985138)	Neverov N.I.... Ivanov A.A.	1994	ALB
49	The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. (7957077)	Zwacka R.M.... Weiher H.	1994	MPV17
50	A molecular biologic study of extracellular matrix co mponents during the development of glomerulosclerosis in murine chronic graft-v ersus-host disease. (1434537)	Munaut C.... Bruijn J.A.	1992	LAMB1, LAMC1

Genes related to glomerulosclerosis according to GeneCards:

(show top 50)    (show all 116)

id	Symbol	Description	Score	GeneCards Section Context
1	ACTN4	actinin, alpha 4	11.1	Publications, Aliases & Descriptions, Summaries
2	TRPC6	transient receptor potential cation channel, subfamily C, member 6	11.1	Summaries, Publications
3	INF2	inverted formin, FH2 and WH2 domain containing	11.1	Summaries, Publications
4	MPV17	MpV17 mitochondrial inner membrane protein	11.1	Aliases & Descriptions, Orthologs, Functions, Publications
5	FSGS2	focal segmental glomerulosclerosis 2	11.1	Publications, Aliases & Descriptions
6	MYO1E	myosin IE	11.0	Publications, Summaries
7	ALB	albumin	11.0	Publications
8	NPHS2	nephrosis 2, idiopathic, steroid-resistant (podocin)	11.0	Publications
9	CD2AP	CD2-associated protein	11.0	Publications
10	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
11	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
12	APOL1	apolipoprotein L, 1	11.0
13	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)	11.0	Publications
14	WT1	Wilms tumor 1	11.0	Publications
15	PTPRO	protein tyrosine phosphatase, receptor type, O	11.0	Publications
16	BMP6	bone morphogenetic protein 6	11.0	Publications
17	PLCE1	phospholipase C, epsilon 1	11.0	Summaries
18	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
19	AGTR1	angiotensin II receptor, type 1	11.0	Publications
20	SYNPO	synaptopodin	11.0	Publications
21	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
22	PAX2	paired box 2	11.0	Publications
23	ENPEP	glutamyl aminopeptidase (aminopeptidase A)	11.0	Publications
24	CTGF	connective tissue growth factor	11.0	Publications
25	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
26	PON1	paraoxonase 1	11.0	Publications
27	SMAD3	SMAD family member 3	11.0	Publications
28	SMAD2	SMAD family member 2	11.0	Publications
29	REN	renin	11.0	Publications
30	TGFB1	transforming growth factor, beta 1	11.0	Publications
31	EDN1	endothelin 1	11.0	Publications
32	WT1-AS	WT1 antisense RNA	11.0	Publications
33	LAMB2	laminin, beta 2 (laminin S)	11.0	Publications
34	FABP1	fatty acid binding protein 1, liver	11.0	Publications
35	GPX3	glutathione peroxidase 3 (plasma)	11.0	Publications
36	TFAM	transcription factor A, mitochondrial	11.0	Publications
37	ZMPSTE24	zinc metallopeptidase STE24 homolog (S. cerevisiae)	11.0	Publications
38	SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	11.0	Publications
39	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	11.0	Publications
40	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
41	VLDLR	very low density lipoprotein receptor	11.0	Publications
42	PTPRU	protein tyrosine phosphatase, receptor type, U	11.0	Publications
43	NPHP4	nephronophthisis 4	11.0	Publications
44	COL4A4	collagen, type IV, alpha 4	11.0	Publications
45	GNE	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	11.0	Publications
46	CLCN5	chloride channel, voltage-sensitive 5	11.0	Publications
47	COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	11.0	Publications
48	NRF1	nuclear respiratory factor 1	11.0	Publications
49	COG2	component of oligomeric golgi complex 2	11.0	Publications
50	CHKA	choline kinase alpha	11.0	Publications

Pathways related to glomerulosclerosis according to GeneDecks:

(show top 50)    (show all 153)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion_ECM remodeling41	INF	MMP2, FN1, IGF1R, IGF1, , PLAUR
2	Cell adhesion ECM remodeling10	INF	, SERPINE1, HBEGF, TIMP2, COL4A4, COL4A3
3	Amoebiasis20	10.2	TGFB1, LAMB1, IL6, NOS2, COL4A4, ACTN4
4	TGF-beta signaling pathway20	9.8	SMAD3, BMP6, BMP7, IFNG, TNF, SMAD1
5	Cell adhesion_Integrin-mediated cell adhesion and migration41	9.7	FN1, ITGB1, SRC, COL4A3, COL4A4, ACTN4
6	Inhibition of Angiogenesis by TSP136	9.7	LAMB1, LAMB2, LAMC1, CD36, FN1, THBS1
7	Cell adhesion Integrin-mediated cell adhesion and migration10	9.6	SRC, COL4A3, ITGA3, LAMC1, LAMB1, MYH9
8	Paxillin Interactions36	9.5	CTGF, SRC, IGF1, FGF2, ITGB4, ITGA3
9	Actin-Based Motility by Rho Family GTPases36	9.4	IGF1, CTGF, LTBP1, ITGB4, BMP7, IL2
10	Malaria20	9.4	CD40LG, CD36, TGFB1, THBS1, TNF, ICAM1
11	Chagas disease (American trypanosomiasis)20	9.3	SMAD2, SMAD3, NOS2, ACE, TGFB1, TNF
12	ERK5 Signaling36	9.3	LTBP1, IL6, TGFB1, IL2RA, IL2, BMP7
13	Ras Pathway36	9.2	IGF1R, CTGF, PLCE1, LTBP1, TIMP2, FGF2
14	14-3-3 Induced Intracellular Signaling36	8.8	IGF1, FGF2, IGF1R, TNF, SRC, PLCE1
15	Pathways in cancer20	8.7	MMP2, SMAD2, SLC2A1, MTOR, LAMB1, LAMB2
16	Transendothelial Migration of Leukocytes36	8.7	LAMB1, MYO1E, MYH9, COL4A4, COL4A3, ITGA3
17	Epithelial Adherens Junctions36	8.5	TIMP2, ACTN4, LTBP1, CTGF, SRC, PTPRC
18	ILK Signaling36	8.3	LAMB1, TIMP2, TFAM, MYH9, BMP7, MYO1E
19	Akt Signaling36	8.3	BMP7, IL6, LTBP1, IRS1, ITGB4, IL10
20	Renin-Angiotensin Pathway36	8.1	TGFB1, BMP7, BMP6, CCL2, IGF1, ACE
21	Telomerase Components in Cell Signaling36	8.1	IGF1, CTGF, TIMP2, LTBP1, BMP6, BMP7
22	p53 Mediated Apoptosis36	8.1	TIMP2, LTBP1, CTGF, IGF1, IGF1R, IL6
23	PTEN Pathway36	8.1	BMP7, LAMB1, LAMB2, LAMC1, ITGA3, FN1
24	Rap1 Pathway36	8.1	FYN, BMP6, ITGB4, TGFB1, TIMP2, LTBP1
25	Apoptotic Pathways in Synovial Fibroblasts36	8.1	TNF, TGFB1, BMP7, TIMP2, LTBP1, CTGF
26	Rac1 Pathway36	8.1	TIMP2, IL6, IL2RA, IL2, IGF1, IGF1R
27	PPAR Pathway36	8.0	IL2, ITGB1, TIMP2, LTBP1, CTGF, TNF
28	ERK Signaling36	8.0	IL2, CTGF, COL4A3, SRC, FN1, COL4A4
29	Molecular Mechanisms of Cancer36	7.9	ITGB1, TGFB1, TIMP2, COL4A4, CTGF, IGF1R
30	Cellular Apoptosis Pathway36	7.9	TNF, IGF1, IL6, IL2RA, IL2, FGF2
31	PAK Pathway36	7.8	BMP6, BMP7, FGF2, IL10, IL2, IL2RA
32	Activation of PKC through GPCR36	7.7	IL2RA, FGF2, BMP6, BMP7, IL2, TIMP2
33	Tec Kinases Signaling36	7.7	BMP6, IGF1R, IGF1, TNF, LTBP1, TIMP2
34	Antioxidant Action of Vitamin-C36	7.6	MYO1E, BMP6, BMP7, IL10, IL2, IL2RA
35	Rho Family GTPases36	7.5	LTBP1, LAMC1, LAMB2, LAMB1, BMP7, BMP6
36	JAK-STAT Pathway36	7.5	IFNA1, BMP6, TIMP2, AGTR1, F2RL3, AGT
37	eIF2 Pathway36	7.4	IL2RA, IGF1R, CTGF, LTBP1, TIMP2, IGF1
38	p70S6K Signaling36	7.4	TGFB1, BMP7, BMP6, IRS1, TIMP2, LTBP1
39	Phospholipase-C Pathway36	7.2	IGF1, COL4A4, LTBP1, TIMP2, TGFB1, IGF1R
40	MAPK Signaling36	7.1	BMP6, BMP7, LAMB1, LAMB2, LAMC1, ITGA3
41	p38 Signaling36	6.8	IL2RA, CTGF, TIMP2, PLCE1, LTBP1, TGFB1
42	UPA-UPAR Pathway36	INF	LAMB2, COL4A3, SRC, FN1, MMP2,
43	Pancreatic Adenocarcinoma36	INF	IGF1, IGF1R, , SRC, TGFB1, CTGF
44	Cytoskeleton remodeling Integrin outside-in signaling10	INF	ACTN4, LAMB1, , ITGA3, ITGB1, FN1
45	ECM-receptor interaction20	INF	, COL4A4, LAMB1, THBS1, FN1, ITGB4
46	Cell adhesion Endothelial cell contacts by non-junctional mechanisms10	INF	LAMB1, , ITGB4, FN1, ITGA3, COL4A3
47	Cytoskeleton remodeling_Integrin outside-in signaling41	INF	LAMB1, LAMC1, ITGA3, ITGB1, FN1, COL4A3
48	Glioma Invasiveness36	INF	LTBP1, PLAUR, F2R, FGF2, ITGB4, ITGB1
49	Focal adhesion20	INF	FN1, LAMB2, LAMC1, FYN, THBS1, ITGB4
50	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms41	INF	COL4A4, COL4A3, MAGI1, FN1, ITGB4, ITGA3

Compounds related to glomerulosclerosis according to GeneDecks:

(show top 50)    (show all 469)

id	Compound	Score	Top Affiliating Genes
1	cholesterol32 9 18 9	INF	COG2, REN, , , SERPINE1, VLDLR
2	glutamine32	INF	, VIM, LPL, BMP6, LCAT, CD36
3	thymidine32 18	INF	, BMP6, BMP7, CHKA, MTHFR, ITGB1
4	testosterone32 9 18 9	INF	COG2, VIM, LPL, CHKA, LCAT, MTOR
5	vitamin d32	INF	SERPINE1, VIM, , LPL, BMP6, BMP7
6	phosphatidylinositol32	INF	, BMP6, CHKA, MTOR, FYN, ITGB1
7	alanine32	INF	COG2, , , VIM, , LMNA
8	hyaluronic acid32 18	INF	, VIM, BMP6, CD36, FN1, FGF2
9	vitamin a32 9 18 9	INF	, VIM, , LPL, CHKA, LCAT
10	curcumin32	INF	, MMP14, MMP2, , IL6, CCL2
11	glutamate32	INF	, VIM, BMP6, CHKA, LCAT, MTHFR
12	vegf32	INF	REN, , SERPINE1, LPA, BMP7, MTOR
13	cytochalasin d32 42	INF	, VIM, LPL, CD36, MMP14, MMP2
14	n acetylcysteine32	INF	, CD79A, MMP2, IRS1, IL2RA, APOE
15	h2o232	INF	, LPA, CLCN5, FYN, CD79A, IRS1
16	methotrexate32 34 42 9 9	INF	SERPINE1, VIM, , BMP6, MTHFR, CD79A
17	cycloheximide32	INF	, SERPINE1, VIM, LPL, BMP6, BMP7
18	cyclosporin a32 42	INF	COG2, , LPL, MTOR, MTHFR, FYN
19	aspartate32	INF	, , VIM, , BMP6, CD40LG
20	procollagen32	9.7	VIM, BMP6, ZMPSTE24, CD36, MMP14, MMP2
21	fluvastatin32 34 9 9	12.6	COG2, SERPINE1, LPL, IL6, APOB, CCL2
22	pravastatin32 34 9 18 9	13.2	COG2, SERPINE1, LPA, CHKA, LCAT, IL6
23	vitamin b1232	8.9	LPA, MTHFR, CD79A, CD40LG, APOB, APOE
24	8-isoprostane32	8.8	SERPINE1, MMP2, INS, IL10, IL6, CCL2
25	mycophenolate mofetil32 9 9	10.7	SERPINE1, CD79A, CD36, CD40LG, IL10, IL2
26	creatinine32	INF	REN, , VLDLR, , LMNA, BMP6
27	arginine32	INF	COG2, REN, , LPA, CD79A, CD40LG
28	heparin32 9 18 9	INF	COG2, , SERPINE1, VLDLR, VIM, LPA
29	sodium dodecylsulfate32	INF	, SERPINE1, LPA, LPL, BMP6, LCAT
30	folate32	INF	, VIM, LPA, MTHFR, CD79A, CD40LG
31	simvastatin32 34 42 9 18 9	INF	COG2, , SERPINE1, LPA, LPL, BMP6
32	enalapril32 9 9	INF	REN, SERPINE1, , BMP6, BMP7, IL10
33	dexamethasone32 42 34 9 9	INF	REN, , , SERPINE1, VIM, LPL
34	cysteine32	INF	, , , LPA, PAFAH1B1, LCAT
35	thyroxine32 18	INF	COG2, REN, , LPA, LPL, CHKA
36	homocysteine32 18	INF	COG2, SERPINE1, , LPA, , APOB
37	rapamycin32 42	INF	VIM, MTOR, FN1, IRS1, INS, IL2
38	oxygen32 18	INF	, , CHKA, FYN, MPV17, ITGB1
39	epinephrine32 9 18 9	INF	REN, , BMP6, CD79A, MMP2, INS
40	norepinephrine32 9 18 9	INF	REN, LPL, BMP6, CD79A, CD40LG, MMP2
41	ascorbic acid32 18	INF	, BMP7, CHKA, LCAT, CD36, CD40LG
42	thalidomide32 42 9 9	INF	, CD36, CD40LG, FGF2, IL10, IL2
43	chloroquine32 34 9 9	INF	, BMP6, CD79A, IL10, IL2, IL2RA
44	hydrocortisone32 9 9	INF	REN, VIM, BMP6, CD36, MMP2,
45	phosphatidylcholine32	INF	VIM, LPA, LPL, PAFAH1B1, CHKA, LCAT
46	fibrinogen32	INF	COG2, , SERPINE1, LPA, CD79A, CD40LG
47	tyrosine32	INF	, VLDLR, BMP6, BMP7, PAX2, CHKA
48	troglitazone32 42 9 9	INF	SERPINE1, LPL, BMP6, CD36, MMP2, FN1
49	neopterin32	INF	, CD79A, CD40LG, IL10, IL2, IL2RA
50	ly29400232	INF	, MMP14, MMP2, FN1, IRS1, FGF2

Cellular components related to glomerulosclerosis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	INF	, IL2, IL6, APOB, APOE, CCL2
2	slit diaphragm	GO:036057	10.5	NPHS2, TRPC6, NPHS1
3	platelet alpha granule lumen	GO:031093	10.4	THBS1, SERPINE1, FN1, IGF1, TGFB1, ACTN4
4	cell leading edge	GO:031252	10.1	VIM, MYH9, ITGB4, PAFAH1B1
5	high-density lipoprotein particle	GO:034364	10.0	PON1, LCAT, APOL1, APOE
6	basement membrane	GO:005604	10.0	ITGB1, TIMP2, LAMC1, LAMB2, LAMB1, COL4A3
7	membrane raft	GO:045121	10.0	ITGB1, TNF, CD36, PTPRC, NPHS1, NPHS2
8	very-low-density lipoprotein particle	GO:034361	9.8	APOL1, VLDLR, LPL, APOB, APOE
9	external side of plasma membrane	GO:009897	9.3	ENPEP, ITGB1, CD40LG, CD36, ATP6AP2, CD79A
10	integral to plasma membrane	GO:005887	8.1	F2RL3, CLCN5, SCARB2, CD36, AGTR1, PTPRC
11	cell surface	GO:009986	INF	VLDLR, LPL, CD36, ITGA3, ITGB1, ITGB4
12	extracellular space	GO:005615	INF	IGFBP1, MMP2, FN1, , INS, FGF2
13	cortical cytoskeleton	GO:030863	INF	NOS2, , ACTN4, MYH9
14	plasma membrane	GO:005886	INF	PLAUR, SMAD3, CTGF, SRC, PTPRC, PTPRO
15	extracellular matrix	GO:031012	INF	THBS1, MMP14, FN1, LTBP1, LAMB1, LAMB2

Biological processes related to glomerulosclerosis according to GeneDecks:

(show top 50)    (show all 72)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	INF	IGF1, , MTOR, CD36, ITGB1,
2	glomerular basement membrane development	GO:032836	10.9	NPHS1, COL4A4, WT1, MYO1E, COL4A3, MPV17
3	glomerulus development	GO:032835	10.8	ENPEP, PLCE1, PTPRO, WT1
4	kidney development	GO:001822	10.7	AGTR1, BMP6, WT1, SMAD1, REN, AGT
5	SMAD protein complex assembly	GO:007183	10.6	SMAD2, SMAD3, SMAD1
6	renin-angiotensin regulation of aldosterone production	GO:002018	10.6	REN, AGT, AGTR1
7	ureteric bud development	GO:001657	10.6	SMAD3, SMAD2, WT1, TGFB1, SMAD1, BMP7
8	regulation of vasoconstriction	GO:019229	10.6	EDN1, AGT, ACE, AGTR1
9	positive regulation of blood coagulation	GO:030194	10.5	CD36, THBS1, F2R, SERPINE1
10	response to hypoxia	GO:001666	10.5	ACTN4, THBS1, EDN1, TGFB1, SMAD3, NOS2
11	platelet degranulation	GO:002576	10.4	IGF1, THBS1, ALB, TF, FN1, CD36
12	response to wounding	GO:009611	10.4	ITGB4, F2R, F2RL3, CTGF, TGFB1, FN1
13	phospholipase C-activating G-protein coupled receptor signaling pathway	GO:007200	10.4	F2RL3, F2R, PLCE1, AGT, AGTR1
14	regulation of cell growth	GO:001558	10.4	IGFBP3, CTGF, PLCE1, AGT, AGTR1, IGFBP2
15	positive regulation of epithelial cell proliferation	GO:050679	10.3	IGF1, LAMC1, LAMB1, BMP6, TGFB1, PAX2
16	B cell proliferation	GO:042100	10.3	CD79A, CD40LG, IL10, PTPRC
17	induction of apoptosis	GO:006917	10.3	WT1, APOE, IFNA2, TNF, SMAD3, TGFB1
18	protein kinase B signaling cascade	GO:043491	10.3	PAX2, IRS1, CCL2, TNF, TGFB1
19	response to glucocorticoid stimulus	GO:051384	10.2	CCL2, SERPINE1, LCAT, IL10, IL6, IGFBP2
20	positive regulation of cellular protein metabolic process	GO:032270	10.2	AGT, INS, TGFB1, AGTR1
21	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.1	AGTR1, LPL, CD36, AGT, APOB
22	response to amino acid stimulus	GO:043200	10.0	MTOR, EDN1, CCL2, CTGF, ICAM1
23	cellular response to lipopolysaccharide	GO:071222	9.9	ICAM1, SERPINE1, VLDLR, NOS2, CD36, IL10
24	response to glucose stimulus	GO:009749	9.9	GIPR, SMAD2, THBS1, TGFB1, COL4A3, CTGF
25	lipoprotein metabolic process	GO:042157	9.9	ALB, APOB, LCAT, LPL, LPA, APOL1
26	negative regulation of blood vessel endothelial cell migration	GO:043537	9.9	TGFB1, THBS1, APOE, FGF2
27	positive regulation of osteoblast differentiation	GO:045669	9.8	SMAD1, BMP6, IGF1, IL6, FGF2, BMP7
28	positive regulation of MAPK cascade	GO:043410	9.7	IGF1, AGT, PTPRC, F2R, IL6, INS
29	elevation of cytosolic calcium ion concentration	GO:007204	9.6	F2R, AGTR1, TRPC6, GIPR, PLCE1, IL2
30	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	ICAM1, INS, IFNG, EDN1, TNF
31	positive regulation of protein kinase B signaling cascade	GO:051897	9.5	MTOR, INS, THBS1, TGFB1, TNF, HBEGF
32	response to drug	GO:042493	9.4	THBS1, TGFB1, FYN, ITGB1, CCL2, ICAM1
33	negative regulation of cell proliferation	GO:008285	9.4	CDKN1C, ITGB1, FGF2, IGFBP3, IL6, IGF1
34	protein kinase C-activating G-protein coupled receptor signaling pathway	GO:007205	9.4	EDN1, IL2, F2R, PLCE1, DGKQ
35	platelet activation	GO:030168	9.2	TF, CD40LG, TGFB1, THBS1, ACTN4, SRC
36	lipid metabolic process	GO:006629	9.2	APOB, ALB, APOE, CD36, LCAT, CHKA
37	leukocyte migration	GO:050900	9.1	ITGB1, THBD, MYH9, APOB, SRC, ICAM1
38	positive regulation of cell migration	GO:030335	9.0	ITGB1, SMAD3, HBEGF, TGFB1, THBS1, EDN1
39	anti-apoptosis	GO:006916	8.6	CCL2, IGF1R, IL2, PAX2, THBS1, CD40LG
40	blood coagulation	GO:007596	8.4	SERPINE1, FYN, IFNA2, IGF1, F2RL3, CD36
41	positive regulation of cell proliferation	GO:008284	7.8	IL6, TGFB1, IRS1, CTGF, ITGB1, INS
42	leukocyte cell-cell adhesion	GO:007159	INF	, PTPRC, ICAM1, ITGB1, CD40LG
43	inflammatory response	GO:006954	INF	BMP6, TGFB1, SMAD1, TNF, F2R, IFNA2
44	positive regulation of transcription, DNA-dependent	GO:045893	INF	TFAM, SMAD2, BMP7, PAX2, CDKN1C, FGF2
45	cell surface receptor signaling pathway	GO:007166	INF	CD36, EDN1, IFNG, , IL2RA, MAGI1
46	axon guidance	GO:007411	INF	LAMB1, LAMB2, LAMC1, COL4A4, ITGB1, FYN
47	negative regulation of gene expression	GO:010629	INF	FYN, , IFNA2, TNF, PLAUR, NOS2
48	negative regulation of apoptotic process	GO:043066	INF	ALB, INS, IL6, FABP1, IGF1R, SERPINE1
49	negative regulation of blood coagulation	GO:030195	INF	, EDN1, THBD, SERPINE1, APOE
50	cell adhesion	GO:007155	INF	CCL2, , SDK1, SCARB2, IL2, LAMB1

Molecular functions related to glomerulosclerosis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	MMP14, IGFBP2, IGFBP3, IGF1, IFNA2, ICAM1
2	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	GO:030618	10.3	SMAD1, SMAD2, SMAD3
3	fibronectin binding	GO:001968	10.2	IGFBP3, CTGF, THBS1, ITGB1, LPA
4	insulin-like growth factor I binding	GO:031994	9.9	IGFBP3, IGFBP2, IGF1R
5	insulin-like growth factor binding	GO:005520	9.8	CTGF, IGFBP3, IGFBP1, IGF1R
6	insulin-like growth factor receptor binding	GO:005159	9.6	REN, INS, IRS1, IGF1
7	glycosphingolipid binding	GO:043208	9.0	LAMC1, LAMB1, IL2
8	growth factor activity	GO:008083	8.6	AGT, HBEGF, CTGF, IGF1, IL6, IL2
9	cytokine activity	GO:005125	INF	IL10, TNF, FGF2, EDN1, IFNG, IFNA2
10	integrin binding	GO:005178	INF	ITGB1, LAMB2, LAMB1, , IGF1, TIMP2
11	heparin binding	GO:008201	INF	PTPRC, CTGF, HBEGF, THBS1, PAFAH1B1, LPL