MCID: GLM008
MIFTS: 56

Glomus Tumor malady

Cancer diseases category

Summaries for Glomus Tumor

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards: Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and neurofibromatosis. An important gene associated with Glomus Tumor is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Glycolysis and gluconeogenesis (short map) and Pyruvate metabolism. The compounds dexamethasone and creatinine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related mouse phenotypes are integument and muscle.

Wikipedia:63 A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\" or glomangioma) is a... more...

Aliases & Classifications for Glomus Tumor

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

glomus tumor 8 44 48 60
glomus neoplasm 8
glomus tumour 8


External Ids:

Disease Ontology8 DOID:2431
NCIt39 C3060
MeSH34 D005918

Related Diseases for Glomus Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1glomangioma30.9GLMN
2neurofibromatosis30.6VHL, S100B, NGFR, KRAS, SDHD, SDHB
3hemangiopericytoma30.6ACTC1, CD34, MUC1, NGFR, DES, S100A1
4smooth muscle tumor30.3VIM, S100B, S100A1, DES, ACTC1
5paraganglioma30.3S100B, VHL, S100A1, SYP, SDHD, SDHB
6hemangioma30.2CD34, VHL, SDHB, SDHAF2, SDHD, ACTC1
7leiomyosarcoma30.2VIM, S100B, S100A1, DES, MUC1, CD34
8pleomorphic adenoma30.0VIM, ACTC1, MUC1, DES, S100A1, S100B
9adenoma30.0ACTC1, KRAS, MUC1, SYP, S100A1, VHL
10merkel cell carcinoma30.0SYP
11pancreatitis30.0KRAS
12chondroma30.0SDHB, SDHD
13glomuvenous malformation30.0GLMN, KRIT1
14carotid body tumor30.0SDHD, SDHB
15ischemia30.0SDHB, KRIT1, NGFR
16gastrointestinal stromal tumor30.0SDHB, ACTC1, CD34, DES, S100A1, S100B
17neurofibroma30.0VIM, S100B, S100A1, SYP, NGFR, MUC1
18squamous cell carcinoma30.0VIM, VHL, S100A1, SYP, NGFR, MUC1
19subungual glomus tumor10.7
20glomangiosarcoma10.5
21skin glomus tumor10.4
22glomangiomyoma10.3
23mediastinitis10.3
24vaginitis10.2
25glomus jugulare tumors10.2
26cerebritis10.1
27coats disease10.1
28pacinian tumor10.0
29dermatofibrosarcoma10.0
30osteoarthritis10.0
31gastric lymphoma10.0
32familial glomangioma10.0
33priapism10.0
34spiradenoma10.0
35nodular hidradenoma10.0
36gastric leiomyosarcoma10.0
37extraskeletal chondroma10.0
38cervicitis10.0
39complex regional pain syndrome10.0
40esophagitis10.0
41hidradenoma10.0
42mature teratoma10.0
43mature teratoma of the ovary10.0
44multiple sclerosis10.0
45neuropathy10.0
46peptic ulcer10.0
47periostitis10.0
48peripheral neuropathy10.0
49perivascular tumor10.0
50skin benign neoplasm10.0

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to glomus tumor

Clinical Features for Glomus Tumor

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Drugs & Therapeutics for Glomus Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Glomus Tumor

Genetic Tests for Glomus Tumor

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Anatomical Context for Glomus Tumor

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32MalaCards
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MalaCards organs/tissues related to Glomus Tumor:

32
Smooth muscle, Trachea, Kidney, Bone, Ovary, Tongue, Breast, Lung, Liver, Lymph node, Skin, Testes, Colon, Uterus, Cervix, Endothelial, Spinal cord

Animal Models for Glomus Tumor or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Glomus Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.3S100B, CDKN2B, CD34, KRAS
2MP:00053699.3VHL, NGFR, ACTC1, ACTG1, SMTN
3MP:00053769.0DES, NGFR, GLMN, CD34, ACTC1, SDHD
4MP:00020068.5VHL, MUC1, CDKN2B, CD34, KRAS, SDHD
5MP:00036318.3CRTAC1, SYP, NGFR, GLMN, KRAS, KRIT1
6MP:00053858.0SDHD, VIM, VHL, S100A1, DES, NGFR
7MP:00028738.0SYP, S100A1, S100B, VHL, NGFR, MUC1
8MP:00053847.8VIM, VHL, CRTAC1, NGFR, GLMN, CDKN2B
9MP:00107687.7VIM, VHL, DES, NGFR, GLMN, CDKN2B

Publications for Glomus Tumor

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Sources:
50PubMed
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Articles related to Glomus Tumor:

(show top 50)    (show all 621)
idTitleAuthorsYear
1
Incidence of cranial nerve palsy after preoperative embolization of glomus jugulare tumors using Onyx. (24313612)
2013
2
Less invasive transjugular approach with Fallopian bridge technique for facial nerve protection and hearing preservation in surgery of glomus jugulare tumors. (23739840)
2013
3
Treatment of recurrent glomus tumor using Mohs surgery. (22136509)
2012
4
Symplastic glomus tumor. (22788825)
2012
5
Subungual glomus tumor. (23155853)
2012
6
Glomus tumor of the hallux. Review of the literature and report of two cases. (22443993)
2012
7
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
8
Laparoscopic resection of a gastric glomus tumor. (22654340)
2011
9
Tracheal glomus tumor: a multidisciplinary approach to management. (21255494)
2011
10
Linac-based stereotactic body radiation therapy for treatment of glomus jugulare tumors. (20950881)
2010
11
Renal glomus tumor in an adolescent: a conservative approach. (20620296)
2010
12
Glomus tumor of the hip. An unusual location. (19198725)
2009
13
Malignant glomus tumor of the hand. (18997618)
2009
14
Glomus tumor masquerading for 22 years as osteoarthritis of the hip. (18491482)
2008
15
Tracheal glomus tumor successfully resected with rigid bronchoscopy: a case report. (18758313)
2008
16
Gamma knife surgery for glomus jugulare tumors: an intermediate report on efficacy and safety. (15662818)
2005
17
Glomus tumor of the lower lip. A case report. (16456522)
2005
18
Subungual extraskeletal chondroma mimicking glomus tumor. (12810999)
2003
19
Glomus tumor in the digit of a cat. (12243472)
2002
20
Glomus tumor of the trachea. (11515904)
2001
21
Glomus tumor of the scapular region. (11155308)
2000
22
Pulmonary and mediastinal glomus tumors--report of five cases including a pulmonary glomangiosarcoma: a clinicopathologic study with literature review. (10935651)
2000
23
Glomus tumor of the uterine cervix. (9891244)
1999
24
Glomus tumor of the finger tip and MRI appearance. (10847529)
1999
25
Primary pulmonary glomus tumor: a clinicopathologic and immunohistochemical study of two cases. (9521471)
1998
26
Vaginal glomus tumor presented as a painless cystic mass. (9600827)
1998
27
Glomus tumor of the plantar arch: a case report with magnetic resonance imaging findings. (9347308)
1997
28
Imaging quiz case 2. Glomus tympanicum tumor of the temporal bone. (9158406)
1997
29
Selective embolization of glomus jugulare tumors. (17170921)
1994
30
Case report 749: Primary glomus tumor of bone. (1326122)
1992
31
Intermediate filament proteins and actin isoforms as markers for soft-tissue tumor differentiation and origin. III. Hemangiopericytomas and glomus tumors. (2158236)
1990
32
High resolution MR imaging of glomus tumor. (3029197)
1987
33
Glomus tympanicum tumor with middle cranial fossa extension. (2825095)
1987
34
Glomus jugulare tumors revisited: a ten-year statistical follow-up of 231 cases. (2983157)
1985
35
Skull base surgery for glomus jugulare tumors. (3000187)
1985
36
Leiomyoblastoma vs. glomus tumor. (6093612)
1984
37
Glomus tumor associated with pacinian hyperplasia--case report. (6279724)
1982
38
Intraosseous glomus tumor--case report. (6265542)
1981
39
Glomus tumor treated by prostaglandin inhibition. Report of a case. (228884)
1979
40
Glomus tumor of the digits. (197147)
1977
41
Endocrine-type granules in cells of glomus tumor of the stomach. (172052)
1975
42
Glomus tumor of the stomach. An ultrastructural study. (167701)
1975
43
Radiation therapy of glomus jugulare tumors. (4346382)
1973
44
A multifocal diffuse glomus tumor: case report and review of the literature. (4334060)
1972
45
Nonchromaffin paraganglioma. 3. Glomus jugulare tumors. (4338957)
1972
46
GLOMUS TUMOR OF THE STOMACH. (14209725)
1964
47
Glomus jugulare tumors in the ear. (13188661)
1954
48
Glomus jugularis tumor of the middle ear; carotid body tumor, tympanic body tumor, nonchromaffin paraganglioma. (13157101)
1952
49
The glomus tumor; report of 20 cases. (14819972)
1951
50
GLOMUS TUMOR: GLOMANGIOMA. (17857108)
1938

Genetic Variations for Glomus Tumor

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Expression for genes affiliated with Glomus Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glomus Tumor

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Pathways for genes affiliated with Glomus Tumor

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Glomus Tumor

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Glomus Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1113.4S100B, KRIT1
2creatinine4410.3ACTC1, SDHB, SYP
3UBIQUINONE-11110.2SDHB, SDHD
4fumarate44 1111.1SDHB, SDHD, VHL
5glycogen44 2411.1SDHB, ACTC1, SYP, VHL
6eosin4410.1S100B, VIM, MUC1
7forskolin44 49 1112.1NGFR, VIM
8orcein4410.1VIM, DES, ACTC1, S100B
92-methoxyethanol4410.1VIM, S100A1, ACTC1
10toluidine4410.1VIM, DES, S100A1
11acetylcholine44 49 28 11 2414.0S100A1, SYP, NGFR
12ganglioside4410.0DES, SYP, NGFR, VIM
13glutamate4410.0NGFR, KRIT1
14dbc-amp449.9S100B, VIM, NGFR, SYP
15actomyosin449.9VIM, KRIT1, ACTC1, S100A1
16gold449.9MUC1, SYP, KRIT1, DES
17glucose449.8MUC1, NGFR, SDHB, ACTC1
18choline44 11 2411.8NGFR, VIM, S100B, SYP
19imatinib44 49 1111.7S100B, ACTC1, KRAS, DES
20nmda44 2810.7SYP, NGFR, KRIT1, SDHB, VIM
21biotin44 11 2411.7VIM, ACTC1, MUC1, DES, S100A1
22dihydrotestosterone44 28 11 2412.7VIM, MUC1, SMTN, DES
23s 100449.7VIM, S100B, SYP, MUC1, ACTC1, DES
24silver449.6S100A1, DES, SYP, CD34
25actinomycin d449.6VHL, DES, KRIT1, VIM, MUC1
26catecholamine449.6SDHD, NGFR, SYP, S100B, VIM, SDHB
27ethanol44 49 11 2412.5S100B, DES, SYP, NGFR, MUC1, SDHB
28h2o2449.5DES, KRAS, KRIT1, VIM, SDHB, SYP
2912-o-tetradecanoylphorbol 13-acetate449.4DES, MUC1, CD34, NGFR, VIM
30formaldehyde44 2410.4MUC1, KRIT1, VIM, S100B, DES, ACTC1
31mucicarmine449.3VIM, S100B, S100A1, DES, SYP, ACTC1
32b 723449.3MUC1, ACTC1, SYP, DES, S100A1, S100B
33cyclic amp44 2410.3VIM, KRIT1, MUC1, NGFR, SYP, DES
34reticulin449.2VIM, ACTC1, CD34, MUC1, SYP, DES
35testosterone44 59 11 2412.2SDHB, ACTC1, KRIT1, S100B, MUC1, SYP
36iron44 2410.1VIM, SDHB, VHL, SDHD, S100B, S100A1
37threonine449.0CDKN2B, MUC1, DES, S100B, NGFR, KRIT1
38nitric oxide44 11 2410.9VHL, SYP, KRIT1, MUC1, NGFR, DES
39oxygen44 249.8MUC1, SDHB, S100B, DES, KRAS, NGFR
40thymidine44 249.8CD34, MUC1, NGFR, DES, S100B
41cysteine448.7S100A1, MUC1, S100B, VIM, NGFR, KRIT1
42lipid448.7MUC1, KRAS, S100B, VIM, SYP, NGFR
43hematoxylin448.6DES, MUC1, SYP, VIM, S100B, S100A1
44progesterone44 59 28 11 2412.6S100B, NGFR, S100A1, DES, SYP, VIM
45serine448.5S100B, SYP, CDKN2B, VIM, NGFR, MUC1
46paraffin448.3KRAS, CD34, MUC1, NGFR, SYP, DES
47vegf448.2ACTC1, MUC1, NGFR, SYP, CD34, KRAS
48calcium44 49 11 2411.2SDHB, SYP, NGFR, MUC1, ACTG1, KRIT1
49retinoic acid44 249.0S100B, DES, S100A1, SYP, NGFR, MUC1
50tyrosine447.5MUC1, CDKN2B, CD34, KRAS, KRIT1, ACTC1

GO Terms for genes affiliated with Glomus Tumor

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16Gene Ontology
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Cellular components related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.8ACTG1, ACTC1, VIM
2mitochondrial respiratory chain complex IIGO:0057499.8SDHB, SDHD

Biological processes related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.0ACTC1, DES, VIM

Molecular functions related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:04803910.0SDHD, SDHB
2structural constituent of cytoskeletonGO:0052009.8ACTG1, DES, VIM
3S100 protein bindingGO:0445489.5S100A1, S100B
4identical protein bindingGO:0428029.0ACTG1, SYP, DES, S100A1, S100B, VIM
5protein bindingGO:0055157.1NGFR, DES, S100A1, S100B, VHL, VIM

Products for genes affiliated with Glomus Tumor

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Sources for Glomus Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet