MCID: GLM008
MIFTS: 59

Glomus Tumor malady

Cancer diseases, Rare diseases categories

Summaries for Glomus Tumor

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Disease Ontology:9 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards: Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and neurofibromatosis. An important gene associated with Glomus Tumor is DES (desmin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoplasmic microtubules. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related mouse phenotypes are digestive/alimentary and craniofacial.

Wikipedia:66 A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\" or glomangioma) is a... more...

Aliases & Classifications for Glomus Tumor

About this section
Sources:
9Disease Ontology, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 50 
Rare tumors


Characteristics (Orphanet epidemiological data):

50
glomus tumor:
Age of onset: Variable


Aliases & Descriptions:

glomus tumor 9 46 50 63
glomus neoplasm 9
glomus tumour 9


External Ids:

Disease Ontology9 DOID:2431
NCIt41 C3060
MeSH36 D005918

Related Diseases for Glomus Tumor

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1glomangioma31.2GLMN
2neurofibromatosis30.8NF1, SDHD, SDHB
3hemangiopericytoma30.6S100B, S100A1, ACTC1, MUC1, VIM, NGFR
4paraganglioma30.3NF1, S100B, S100A1, VHL, SYP, SDHAF2
5leiomyosarcoma30.3DES, VIM, MUC1, ACTC1, S100A1, S100B
6hidradenoma30.3MUC1
7chondroma30.3SDHB, SDHD
8carotid body tumor30.2SDHB, SDHD
9hemangioma30.2KRIT1, NF1, VHL, ACTC1, SDHAF2, SDHD
10glomuvenous malformation30.2KRIT1, GLMN
11merkel cell carcinoma30.2MUC1, SYP
12pleomorphic adenoma30.2DES, VIM, MUC1, ACTC1, S100A1, S100B
13multiple endocrine neoplasia30.1NF1, VHL, SDHD, SDHB
14dermatofibrosarcoma protuberans30.1S100B, S100A1, ACTC1, MUC1, VIM, DES
15gastrointestinal stromal tumor30.0NF1, S100B, S100A1, ACTC1, VIM, SDHB
16adenoma30.0BRAF, MUC1, ACTC1, SYP, VHL, S100A1
17neurofibroma30.0VIM, NGFR, MUC1, ACTC1, SYP, NF1
18subungual glomus tumor10.8
19glomangiosarcoma10.5
20glomus jugulare tumors10.4
21skin glomus tumor10.4
22glomangiomyoma10.3
23mediastinitis10.3
24vaginitis10.2
25infantile myofibromatosis10.1DES
26adenomatoid tumor10.1VIM
27kidney cancer10.1VHL
28nephrogenic adenoma10.1S100A1
29fasciitis10.1ACTC1
30melanotic neuroectodermal tumor10.1SYP
31cavernous hemangioma10.1KRIT1
32carney triad10.1SDHB, SDHD
33phaeochromocytoma10.1SDHD, SDHB
34paraganglioma and gastric stromal sarcoma10.1SDHB, SDHD
35leiomyomatosis10.1VHL, SDHB
36malignant peripheral nerve sheath tumor10.1NF1
37desmoid tumor10.1ACTC1, DES
38alveolar soft part sarcoma10.1DES, VIM
39cystadenocarcinoma10.1MUC1
40adenosarcoma10.1DES, ACTC1
41rosai-dorfman disease10.1S100B
42desmoplastic small round cell tumor10.1MUC1, DES
43papilloma10.1ACTC1, CDKN2B
44langerhans-cell histiocytosis10.1S100B, S100A1
45clear cell ependymoma10.1MUC1, VIM
46ganglioglioma10.1S100B, SYP
47papillary ependymoma10.1SYP, S100B
48epithelioid leiomyosarcoma10.1ACTC1, VIM, DES
49pseudosarcomatous fibromatosis10.1DES, VIM, ACTC1
50neurilemmoma10.1NF1

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to glomus tumor

Symptoms for Glomus Tumor

About this section

Drugs & Therapeutics for Glomus Tumor

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Glomus Tumor

Drug clinical trials:

Search ClinicalTrials for Glomus Tumor

Search NIH Clinical Center for Glomus Tumor

Search CenterWatch for Glomus Tumor

Genetic Tests for Glomus Tumor

About this section

Anatomical Context for Glomus Tumor

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Glomus Tumor:

34
Smooth muscle, Trachea, Kidney, Bone, Ovary, Tongue, Breast, Lung, Liver, Lymph node, Skin, Testes, Colon, Uterus, Cervix, Endothelial, Spinal cord

Animal Models for Glomus Tumor or affiliated genes

About this section
Sources:
38MGI
See all sources

Publications for Glomus Tumor

About this section
Sources:
53PubMed
See all sources

Articles related to Glomus Tumor:

(show top 50)    (show all 462)
idTitleAuthorsYear
1
Tracheal glomus tumor: two cases with bronchoscopic intervention. (24384448)
2014
2
A rare large tracheal glomus tumor with postoperative haematemesis. (24255789)
2013
3
Glomus tumor of the cheek: a case report. (22811718)
2012
4
Treatment of recurrent glomus tumor using Mohs surgery. (22136509)
2012
5
Glomus Tumor Presenting as Raynaud's Phenomenon. (22811722)
2012
6
Percutaneous radiofrequency ablation of primary intraosseous spinal glomus tumor. (22072240)
2012
7
A new case of lower extremity glomus tumor up-to date review and case report. (22802895)
2012
8
Symplastic glomus tumor. (22788825)
2012
9
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
10
Large glomus tumor presenting in a 9-year-old. (21493250)
2011
11
Primary glomus tumor of the liver: a rare case report and review of the literature. (21934228)
2011
12
Glomus tumor of the ovary: a case report. (20667926)
2010
13
A glomus tumor anterior to the patellar tendon: a case report. (21088468)
2010
14
Glomus tumor of the hip. An unusual location. (19198725)
2009
15
Glomus tumor of the breast: first report. (18446361)
2009
16
Glomus tumor of the toe with symptoms similar to those of Morton's disease. (19997833)
2009
17
Intraosseous glomus tumor of the great toe: a case report with review of the literature. (18590892)
2008
18
Intraorbital and intracranial soft-tissue glomus tumor in an 8-year-old child. Case report. (18447675)
2008
19
Glomus tumor. (18788860)
2008
20
Glomus tumor of the ampulla. (17521650)
2007
21
A clinicopathologic study of glomus tumor of the stomach. (16940885)
2006
22
Glomangiomyoma (glomus tumor) of the kidney. (16119994)
2005
23
Extradigital glomus tumor of the triceps tendon as a cause of elbow pain: a case report. (12934039)
2003
24
Ultrasound pattern of glomus tumor of the shoulder. (12589272)
2002
25
Glomus tumor of the trachea. (11515904)
2001
26
An additional case of solitary subungual glomus tumor associated with neurofibromatosis 1. (10920593)
2000
27
Multiple glomus tumor: a case report and review of the literature. (10517474)
1999
28
Malignant glomus tumor. A case report of widespread metastases in a patient with multiple glomus body hamartomas. (8554113)
1996
29
Glomus tumor of the upper lip. (7674003)
1995
30
Radiologic case study. Glomus tumor. (7479417)
1995
31
Extradigital glomus tumor as a cause of knee pain. (8248416)
1993
32
Subungual glomus tumor: diagnosis based on high-resolution MR images. (1332458)
1992
33
Congenital arterial anomaly in the middle ear presenting as a glomus tumor. (1487462)
1992
34
Mantle zone lymphoma in a gastric glomus tumor. (1327492)
1992
35
Intraosseous glomus tumor in the upper thoracic spine complicating compression myelopathy. A case report. (1658951)
1991
36
Intraosseous glomus tumor: report of a case and review of the literature. (3019113)
1986
37
A case report of glomus tumor of the stomach. (6330409)
1984
38
Glomus tumor (golomangioma) of the tongue. A light and electron microscopic study. (6270610)
1981
39
Glomus tumor of the digits. (197147)
1977
40
Glomus tumor of the stomach--a case report]. (185440)
1976
41
Glomus tumor or glomangioma in podiatric medicine. (168245)
1975
42
A multifocal diffuse glomus tumor: case report and review of the literature. (4334060)
1972
43
Glomangioma (glomus tumor): report of case with 50-year history. (4326125)
1971
44
Subungual glomus tumor. Radiological manifestations. (4322892)
1970
45
Glomus tumor of the stomach. (14002266)
1962
46
Hemangiopericytoma (glomus tumor) of the mediastinum; review of the literature and report of case. (13187186)
1954
47
Subungual glomus tumor; report of a case. (18890423)
1948
48
Case of glomus tumor. (20241073)
1947
49
The glomus tumor. (20983245)
1945
50
Neuromyoarterial Glomus Tumor in the Eyelid. (16693240)
1940

Variations for Glomus Tumor

About this section

Expression for genes affiliated with Glomus Tumor

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Glomus Tumor

Search GEO for disease gene expression data for Glomus Tumor.

Pathways for genes affiliated with Glomus Tumor

About this section
Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 13EMD Millipore, 61Thomson Reuters, 5Cell Signaling Technology, 56Reactome, 55R&D Systems, 54QIAGEN
See all sources

Pathways related to Glomus Tumor according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.7DES, ACTG1, ACTC1
2
Show member pathways
Cytoskeleton remodeling Neurofilaments61
9.6ACTG1, VIM, DES
39.5ACTC1, ACTG1, VIM, DES
4
Show member pathways
9.5ACTC1, ACTG1, VIM, DES
5
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion61
Pathogenic Escherichia coli infection39
9.4ACTC1, ACTG1, BRAF
69.3S100B, VHL, SYP, NGFR
79.3BRAF, VHL, KRAS
8
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.2BRAF, KRAS, CDKN2B
9
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.2KRAS, MUC1, BRAF
109.0BRAF, VHL, KRAS, CDKN2B
118.9KRAS, NF1, BRAF
12
Show member pathways
Signaling Pathways in Glioblastoma39
8.6BRAF, NF1, KRAS, CDKN2B
13
Show member pathways
7.7NGFR, BRAF, ACTG1, NF1, KRAS, KRIT1
14
Show member pathways
7.3CDKN2B, DES, NGFR, BRAF, VIM, MUC1

Compounds for genes affiliated with Glomus Tumor

About this section
Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR, 62Tocris Bioscience
See all sources

Compounds related to Glomus Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1orcein4610.0DES, VIM, ACTC1, S100B
2eosin469.9VIM, MUC1, S100B
3fumarate46 1210.7VHL, SDHD, SDHB
4ganglioside469.6DES, NGFR, VIM, SYP
5s 100469.5DES, VIM, MUC1, ACTC1, SYP, S100B
62-methoxyethanol469.5S100A1, ACTC1, VIM
7reticulin469.5DES, VIM, MUC1, ACTC1, SYP, S100B
8succinate469.5SDHB, SDHD, VHL, NF1
9dbc-amp469.4NGFR, VIM, SYP, S100B
10toluidine469.4S100A1, VIM, DES
11catecholamine469.3NGFR, SDHB, SDHD, VIM, SYP, S100B
12gold469.2DES, BRAF, MUC1, SYP, KRIT1
13actomyosin469.2VIM, ACTC1, S100A1, KRIT1
14ethanol46 52 25 1212.2DES, NGFR, SDHB, MUC1, SYP, S100B
15creatinine469.2DES, SDHB, VIM, MUC1, ACTC1, SYP
16biotin46 25 1211.1DES, VIM, MUC1, ACTC1, S100A1
17formaldehyde46 2510.1DES, VIM, MUC1, ACTC1, SYP, S100B
18nmda46 3010.1KRIT1, SYP, VIM, SDHB, NGFR
19imatinib46 52 1211.1DES, BRAF, ACTC1, S100B, KRAS
20matrigel468.9NGFR, BRAF, VIM, MUC1, ACTC1
2112-o-tetradecanoylphorbol 13-acetate468.9DES, NGFR, BRAF, VIM, MUC1
22testosterone46 62 25 1211.9DES, SDHB, VIM, MUC1, ACTC1, SYP
23acetylcholine46 52 30 25 1212.7DES, NGFR, VIM, SYP, S100A1, S100B
24b 723468.7VIM, MUC1, ACTC1, SYP, S100A1, S100B
25mucicarmine468.6S100B, DES, VIM, MUC1, ACTC1, SYP
26methionine468.5DES, VIM, S100B, NF1, KRIT1
27iron46 259.5DES, SDHB, SDHD, VIM, ACTC1, VHL
28dexamethasone46 52 30 1211.5NGFR, VIM, MUC1, ACTG1, ACTC1, SYP
29rapamycin468.5BRAF, VIM, VHL, NF1, GLMN, KRAS
30glutamate468.5NGFR, SDHB, BRAF, VIM, SYP, S100B
31glucose468.4DES, NGFR, SDHB, BRAF, MUC1, ACTC1
32oxygen46 259.4DES, NGFR, SDHB, SDHD, MUC1, ACTC1
33threonine468.4DES, NGFR, BRAF, MUC1, S100B, KRIT1
34arginine468.3DES, SDHB, BRAF, VIM, S100B, NF1
35hematoxylin468.3DES, NGFR, VIM, MUC1, ACTC1, SYP
36gtp46 309.3BRAF, SYP, S100B, NF1, KRAS, KRIT1
37forskolin46 52 1210.3NGFR, BRAF, VIM, MUC1, SYP, S100B
38glycogen46 259.2DES, SDHB, VIM, MUC1, ACTC1, SYP
39nitric oxide46 25 1210.0DES, NGFR, MUC1, SYP, VHL, S100A1
40cyclic amp46 258.8DES, NGFR, BRAF, VIM, MUC1, SYP
41vegf467.6DES, NGFR, SDHB, BRAF, VIM, MUC1
42lipid467.6NGFR, SDHB, BRAF, VIM, MUC1, SYP
43cysteine467.2DES, NGFR, SDHB, VIM, MUC1, SYP
44progesterone46 30 62 25 1211.1DES, NGFR, BRAF, VIM, MUC1, ACTC1
45serine466.8DES, NGFR, BRAF, VIM, MUC1, SYP
46paraffin466.7DES, NGFR, BRAF, VIM, MUC1, ACTC1
47retinoic acid46 257.4DES, NGFR, BRAF, VIM, MUC1, ACTC1
48calcium46 52 25 129.1MUC1, BRAF, SDHB, NGFR, DES, ACTG1
49tyrosine465.8ACTC1, MUC1, BRAF, SDHB, NGFR, DES
50estrogen465.8VIM, MUC1, ACTC1, SYP, VHL, S100A1

GO Terms for genes affiliated with Glomus Tumor

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057499.8SDHD, SDHB
2cytosolGO:0058298.0NGFR, BRAF, VIM, ACTG1, ACTC1, VHL

Biological processes related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of neuronal synaptic plasticityGO:0481689.9S100B, SYP
2muscle filament slidingGO:0300499.8DES, VIM, ACTC1
3regulation of long-term neuronal synaptic plasticityGO:0481699.2KRAS, NF1, SYP
4regulation of synaptic transmission, GABAergicGO:0322289.1KRAS, NF1

Molecular functions related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:04803910.0SDHD, SDHB
2structural constituent of cytoskeletonGO:0052009.4DES, VIM, ACTG1
3S100 protein bindingGO:0445489.3S100B, S100A1
4identical protein bindingGO:0428027.8DES, BRAF, VIM, ACTG1, SYP, S100A1
5protein bindingGO:0055154.7CDKN2B, DES, NGFR, SDHB, SDHAF2, BRAF

Products for genes affiliated with Glomus Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glomus Tumor

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet