MCID: GLM008
MIFTS: 42

Glomus Tumor malady

Categories: Rare diseases, Cardiovascular diseases, Cancer diseases

Aliases & Classifications for Glomus Tumor

Aliases & Descriptions for Glomus Tumor:

Name: Glomus Tumor 12 56 52 42 14 69
Glomus Neoplasm 12
Glomus Tumour 12

Characteristics:

Orphanet epidemiological data:

56
glomus tumor
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:2431
MeSH 42 D005918
NCIt 47 C3060
Orphanet 56 ORPHA391651
ICD10 via Orphanet 34 D18.0
UMLS 69 C0017653

Summaries for Glomus Tumor

Disease Ontology : 12 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards based summary : Glomus Tumor, also known as glomus neoplasm, is related to skin glomus tumor and glomangioma. An important gene associated with Glomus Tumor is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Integrated Cancer Pathway. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related phenotypes are cardiovascular system and mortality/aging

Wikipedia : 71 A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\" or glomangioma) is a... more...

Related Diseases for Glomus Tumor

Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
id Related Disease Score Top Affiliating Genes
1 skin glomus tumor 33.3 DES VIM
2 glomangioma 30.9 ACTC1 CDKN2B DES SDHB SDHD SYP
3 gastrointestinal stromal tumor 28.6 ACTC1 DES SDHB SDHD SYP TP53
4 subungual glomus tumor 12.1
5 glomangiosarcoma 11.7
6 glomuvenous malformations 11.4
7 paragangliomas 1, with or without deafness 11.1
8 paragangliomas 3 11.0
9 paragangliomas 2 11.0
10 hereditary paraganglioma-pheochromocytoma syndromes 11.0
11 inflammatory linear verrucous epidermal nevus 10.3 DES VIM
12 lymphomatous thyroiditis 10.3 DES VIM
13 marfanoid hypermobility syndrome 10.3 DES VIM
14 adult endodermal sinus tumor 10.3 DES VIM
15 biliary papillomatosis 10.3 DES VIM
16 lymphomatoid papulosis 10.3 ACTC1 VIM
17 tanycytic ependymoma 10.3 DES VIM
18 chest wall parachordoma 10.3 ACTC1 VIM
19 liver angiosarcoma 10.3 DES VIM
20 isolated anterior cervical hypertrichosis 10.3 ACTC1 VIM
21 cavernous sinus meningioma 10.3 DES VIM
22 petrous apex meningioma 10.3 DES VIM
23 oral erosive lichen 10.3 ACTC1 DES
24 vulvar squamous papilloma 10.3 DES VIM
25 carbon monoxide-induced parkinsonism 10.3 ACTC1 DES
26 vagina leiomyosarcoma 10.3 ACTC1 DES
27 testicular granulosa cell tumor 10.3 ACTC1 VIM
28 anal gland neoplasm 10.3 DES VIM
29 jejunal neuroendocrine tumor 10.2 SYP VIM
30 myxopapillary ependymoma 10.2 SYP VIM
31 autosomal recessive stickler syndrome 10.2 SYP VIM
32 lymphangiosarcoma 10.2 ACTC1 VIM
33 microinvasive cervical squamous cell carcinoma 10.2 SYP VIM
34 adult central nervous system primitive neuroectodermal neoplasm 10.2 SYP VIM
35 nephrogenic adenoma of urinary bladder 10.2 SYP VIM
36 behcet's syndrome arthropathy 10.2 SYP VIM
37 episodic ataxia 10.2 ACTC1 DES
38 cauda equina intradural extramedullary astrocytoma 10.2 ACTC1 VIM
39 aneurysm of sinus of valsalva 10.2 SYP VIM
40 pustulosis palmaris et plantaris 10.2 ACTC1 DES
41 adult pineal parenchymal tumor 10.2 SYP VIM
42 gestational trophoblastic neoplasm 10.2 SYP VIM
43 calcific tendinitis 10.2 SYP VIM
44 tinea favosa 10.2 ACTC1 DES
45 jewett-marshall bladder cancer 10.2 DES VIM
46 desmoid tumor 10.2 ACTC1 VIM
47 hunter macpherson syndrome 10.2 ACTC1 SYP
48 verruciform xanthoma of skin 10.2 DES TP53
49 adult brainstem gliosarcoma 10.2 TP53 VIM
50 popliteal pterygium syndrome, bartsocas-papas type 10.2 ACTC1 VIM

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to Glomus Tumor

Symptoms & Phenotypes for Glomus Tumor

MGI Mouse Phenotypes related to Glomus Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 ACTC1 DES SDHB SDHD TP53 VIM
2 mortality/aging MP:0010768 9.17 DES SDHB SDHD TP53 VIM ACTC1

Drugs & Therapeutics for Glomus Tumor

Drugs for Glomus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Alkylating Agents Phase 2, Phase 3
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Antineoplastic Agents, Alkylating Phase 2, Phase 3
10 Isophosphamide mustard Phase 2, Phase 3
11 Topoisomerase Inhibitors Phase 2, Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3

Search NIH Clinical Center for Glomus Tumor

Cochrane evidence based reviews: glomus tumor

Genetic Tests for Glomus Tumor

Anatomical Context for Glomus Tumor

MalaCards organs/tissues related to Glomus Tumor:

39
Smooth Muscle, Trachea, Kidney, Bone, Lung, Liver, Ovary

Publications for Glomus Tumor

Articles related to Glomus Tumor:

(show top 50) (show all 539)
id Title Authors Year
1
A blue middle ear mass: Cholesterol granuloma mimicking a glomus tumor and endolymphatic sac tumor. ( 27931523 )
2017
2
Glomus tumor of the stomach-a tumor that needs to be differentiated from gastrointestinal stromal tumor. ( 28501534 )
2017
3
Subungual Glomus Tumor. ( 27556243 )
2016
4
Glomangiopericytoma and glomus tumor of the sinonasal tract: A report of two cases with emphasis on the differential diagnosis. ( 26972077 )
2016
5
Incidental gastric glomus tumor after laparoscopic sleeve gastrectomy. ( 27284541 )
2016
6
A Rare Case of Glomus Tumor of the Great Toe: An Analysis of Behavior at This Rare Site. ( 26864831 )
2016
7
Malignant Glomus Tumor Arising in a Long Standing Precursor Lesion. ( 26760685 )
2016
8
"Longitudinal hyperkeratotic structure" related to subungual glomus tumor. ( 27542925 )
2016
9
A case of a glomus tumor of the stomach resected by laparoscopy endoscopy cooperative surgery. ( 27593365 )
2016
10
Long-term survival case of malignant glomus tumor mimicking "dumbbell-shaped" neurogenic tumor. ( 27421277 )
2016
11
Malignant Glomus Tumor of the Kidney: A Case Report and Review of the Literature. ( 27349133 )
2016
12
Glomus Tumor of the Stomach: GI Image. ( 27844265 )
2016
13
Glomus tumor in teen and repetition pneumonia: Case report. ( 27766200 )
2016
14
Extradigital Glomus Tumor Revisited: Painful Subcutaneous Nodules Located in Various Parts of the Body. ( 26955123 )
2016
15
Intravascular extra-digital glomus tumor of the forearm. ( 27421300 )
2016
16
Primary pulmonary glomus tumor of uncertain malignant potential: A case report with literature review focusing on current concepts of malignancy grade estimation. ( 27752464 )
2016
17
Role of intraoperative dermoscopy in excision of nail unit glomus tumor. ( 27730057 )
2016
18
Glomus Tumor of Trachea in an Adult Male. ( 27376225 )
2016
19
Sonographic diagnosis of a glomus tumor of the thigh. ( 27444193 )
2016
20
Giant Glomus Tumor and Neuroma in the Fifth Ray A Case Report. ( 27031555 )
2016
21
Dermoscopy of glomus tumor: More white than pink. ( 27317535 )
2016
22
Extradigital glomus tumor: a rare etiology for wrist soft tissue mass. ( 27594949 )
2016
23
Duodenal Glomus Tumor: A Rare Cause of Upper GI Bleeding. ( 27033430 )
2016
24
Glomus tumor located in deltoid muscle. ( 26969962 )
2016
25
Unusual Glomus Tumor of the Penis. ( 27867327 )
2016
26
Malignant Gastric Glomus Tumor: A Case Report and Literature Review of a Rare Entity. ( 26816568 )
2016
27
Gastric glomus tumor. ( 27887020 )
2016
28
Smoothelin and WT-1 expression in glomus tumors and glomuvenous malformations. ( 27184662 )
2016
29
How to treat a glomus tumor of the airways? ( 27601072 )
2016
30
Glomus Tumor: Twenty-Year Experience and Literature Review. ( 26808758 )
2016
31
A Glomus Tumor With Recurrence and Malignant Transformation in the Chest Wall: A Cautionary Tale of Seeding? ( 27772590 )
2016
32
Glomus Tumor Excision With Clitoral Preservation. ( 27015262 )
2016
33
Glomus tumor of the anterior urethra: A rare case report and review of the literature. ( 27284444 )
2016
34
An extremely rare case of a glomus tumor in the popliteal fossa. ( 27408511 )
2016
35
Glomus tumor and the contribution of nerve ultrasound, an additional case. ( 27061178 )
2016
36
Atypical location of a glomus tumor in the liver. ( 27863691 )
2016
37
Epithelioid Glomus Tumor of the Uterine Cervix: A Case Report and Review. ( 26630229 )
2016
38
Mammalian glomus tumor: Contribution of nerve ultrasound. ( 26788862 )
2016
39
Preoperative evaluation of a subungual glomus tumor case using multidetector computed tomography angiography. ( 25834372 )
2015
40
Mediastinal Glomus Tumor: A Case Report and Literature Review. ( 26265686 )
2015
41
Symplastic Glomus Tumor. ( 26456968 )
2015
42
Extradigital Glomus Tumor of Thigh. ( 26236537 )
2015
43
Superficial Fibromatosis Mimicking Glomus Tumor of the Second Toe. ( 26330970 )
2015
44
The value of diagnostic ultrasonography in the assessment of a glomus tumor of the subcutaneous layer of the forearm mimicking a hemangioma: a case report. ( 26351259 )
2015
45
Chronic Long Standing Shoulder Pain, Caused by Glomus Tumor. ( 26266006 )
2015
46
Glomus tumor: revitalizing concepts. ( 26379331 )
2015
47
A Rare Case of Primary Pulmonary Glomus Tumor. ( 26488208 )
2015
48
Malignant glomus tumor of trachea: a case report with literature review. ( 26420909 )
2015
49
Concomitant tracheal and subcutaneous glomus tumor: Case report and review of the literature. ( 26744663 )
2015
50
Translocation (1;5) in a Glomus Tumor. ( 26504045 )
2015

Variations for Glomus Tumor

Expression for Glomus Tumor

Search GEO for disease gene expression data for Glomus Tumor.

Pathways for Glomus Tumor

Pathways related to Glomus Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.98 ACTC1 DES VIM
2 10.92 CDKN2B TP53
3
Show member pathways
10.81 DES VIM
4 10.66 ACTC1 DES VIM
5 10.46 CDKN2B TP53

GO Terms for Glomus Tumor

Cellular components related to Glomus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHB SDHD

Biological processes related to Glomus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.16 SDHB SDHD
2 intermediate filament organization GO:0045109 8.96 DES VIM
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Glomus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.46 DES SYP TP53 VIM
2 protein self-association GO:0043621 9.26 SYP TP53
3 ubiquinone binding GO:0048039 8.96 SDHB SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHB SDHD

Sources for Glomus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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