MCID: GLM008
MIFTS: 43

Glomus Tumor

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Glomus Tumor

MalaCards integrated aliases for Glomus Tumor:

Name: Glomus Tumor 12 55 51 41 14 69
Glomus Neoplasm 12
Glomus Tumour 12

Characteristics:

Orphanet epidemiological data:

55
glomus tumor
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:2431
MeSH 41 D005918
NCIt 46 C3060
Orphanet 55 ORPHA391651
UMLS via Orphanet 70 C0017653
ICD10 via Orphanet 33 D18.0
UMLS 69 C0017653

Summaries for Glomus Tumor

Disease Ontology : 12 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards based summary : Glomus Tumor, also known as glomus neoplasm, is related to skin glomus tumor and paragangliomas 1. An important gene associated with Glomus Tumor is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Carbon metabolism. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related phenotype is cardiovascular system.

Related Diseases for Glomus Tumor

Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
# Related Disease Score Top Affiliating Genes
1 skin glomus tumor 33.8 DES VIM
2 paragangliomas 1 32.3 SDHB SDHD
3 hereditary paraganglioma-pheochromocytoma syndromes 31.7 SDHB SDHD
4 glomangiomyoma 30.5 ACTC1 VIM
5 hemangiopericytoma, malignant 30.4 ACTC1 DES VIM
6 glomangioma 30.0 ACTC1 DES ENO2 VIM
7 fibromatosis 29.8 ACTC1 DES VIM
8 chondroma 29.4 ACTC1 SDHB SDHD
9 spiradenoma 29.3 ACTC1 TP53 VIM
10 paraganglioma 29.1 ENO2 SDHB SDHD SYP
11 merkel cell carcinoma 28.9 ENO2 SYP TP53
12 dermatofibrosarcoma protuberans 28.9 ACTC1 DES TP53 VIM
13 teratoma 28.5 ACTC1 ENO2 SYP TP53
14 leiomyosarcoma 28.4 ACTC1 DES ENO2 TP53 VIM
15 gastrointestinal stromal tumor 26.8 ACTC1 DES ENO2 SDHB SDHD SYP
16 subungual glomus tumor 12.2
17 glomangiosarcoma 11.8
18 glomuvenous malformations 11.5
19 paragangliomas 2 11.2
20 paragangliomas 3 11.2
21 infantile digital fibromatosis 10.5 DES VIM
22 lymphangiomatosis 10.5 DES VIM
23 biphasic synovial sarcoma 10.4 DES VIM
24 lymphangiectasis 10.4 ACTC1 VIM
25 intravascular papillary endothelial hyperplasia 10.4 ACTC1 VIM
26 syringoma 10.4 DES VIM
27 juvenile xanthogranuloma 10.4 DES VIM
28 ovarian fibrothecoma 10.4 ACTC1 DES
29 fibroblastic rheumatism 10.4 ACTC1 DES
30 adenofibroma 10.4 ACTC1 VIM
31 mesenchymal chondrosarcoma 10.4 DES VIM
32 primary hepatic neuroendocrine carcinoma 10.4 SYP VIM
33 rhabdoid meningioma 10.4 SYP VIM
34 episodic pain syndrome, familial, 1 10.4
35 chordoid meningioma 10.4 SYP VIM
36 pulmonary vein stenosis 10.4 ACTC1 DES
37 cystic nephroma 10.4 ACTC1 DES
38 large cell medulloblastoma 10.4 SYP VIM
39 ischemic fasciitis 10.4 ACTC1 DES
40 anaplastic ependymoma 10.4 SYP VIM
41 medulloepithelioma 10.4 SYP VIM
42 sertoli cell tumor 10.3 SYP VIM
43 non-langerhans-cell histiocytosis 10.3 ACTC1 DES
44 fibrolamellar carcinoma 10.3 SYP VIM
45 benign mesothelioma 10.3 DES VIM
46 dendritic cell tumor 10.3 ACTC1 VIM
47 polymorphous low-grade adenocarcinoma 10.3 ACTC1 VIM
48 binswanger's disease 10.3 ACTC1 SYP
49 bednar tumor 10.3 ENO2 VIM
50 myoepithelioma 10.3 ACTC1 VIM

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to Glomus Tumor

Symptoms & Phenotypes for Glomus Tumor

MGI Mouse Phenotypes related to Glomus Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 ACTC1 DES SDHB SDHD TP53 VIM

Drugs & Therapeutics for Glomus Tumor

Drugs for Glomus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Alkylating Agents Phase 2, Phase 3
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Isophosphamide mustard Phase 2, Phase 3 0
10 Topoisomerase Inhibitors Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride

Search NIH Clinical Center for Glomus Tumor

Cochrane evidence based reviews: glomus tumor

Genetic Tests for Glomus Tumor

Anatomical Context for Glomus Tumor

MalaCards organs/tissues related to Glomus Tumor:

38
Smooth Muscle, Trachea, Kidney, Bone, Liver, Lung, Ovary

Publications for Glomus Tumor

Articles related to Glomus Tumor:

(show top 50) (show all 575)
# Title Authors Year
1
A case of a glomus tumor presenting as an atypical hyperkeratotic papule of the hypothenar palm. ( 29296650 )
2018
2
A case of gastric glomus tumor resection using laparoscopy endoscopy cooperative surgery (LECS). ( 29275234 )
2018
3
Rare presentation of the glomus tumor in the stomach. ( 29221662 )
2018
4
The usefulness of nail plate and intraoperative dermoscopy in subungual glomus tumor. ( 29318590 )
2018
5
Glomus tumor of the stomach-a tumor that needs to be differentiated from gastrointestinal stromal tumor. ( 28501534 )
2017
6
Micrometastatic Gastric Glomus Tumor Confirmed by Next-Generation Sequencing. ( 28675515 )
2017
7
Transducing-Like Enhancer of Split 1: A Potential Immunohistochemical Marker for Glomus Tumor. ( 28632567 )
2017
8
Tracheal Glomus Tumor: A Case Report and Review of the Literature. ( 28458792 )
2017
9
Unusual imaging presentation of spinal glomus tumor: case report. ( 29354753 )
2017
10
Breast Cancer Metastasis on the Neck Mimicking a Glomus Tumor. ( 28468218 )
2017
11
Intravenous Glomus Tumor Masquerading as Lateral Antebrachial Cutaneous Neuroma. ( 28344537 )
2017
12
HAS A GLOMUS TUMOR ALWAYS A QUICK DIAGNOSIS? ( 29446307 )
2017
13
An incidental finding of an asymptomatic intraneural glomus tumor: A case report and review of the literature. ( 29272030 )
2017
14
Glomus tumor as a cause of oncogenic osteomalacia. ( 29354168 )
2017
15
Extradigital glomus tumor of the elbow with preoperative ultrasound-guided wire localization: a case report. ( 28941972 )
2017
16
Successful Resection of locally infiltrative Glomus Tumor without pulmonary resection. ( 29096341 )
2017
17
Glomangioma of the Kidney: A Rare Case of Glomus Tumor and Review of the Literature. ( 28698815 )
2017
18
Ultrasound-Guided, Minimally Invasive Resection of a Digital Glomus Tumor. ( 29108647 )
2017
19
Atypically localized glomus tumor causing anterior interosseous nerve syndrome: A case report. ( 29056390 )
2017
20
Breast Cancer Metastasis on the Neck Mimicking a Glomus Tumor. ( 28141650 )
2017
21
Nonintubated Spontaneous Respiration Anesthesia for Tracheal Glomus Tumor. ( 28734442 )
2017
22
BRAF V600E Mutations Occur in a Subset of Glomus Tumors, and Are Associated With Malignant Histologic Characteristics. ( 28834810 )
2017
23
A gastric glomus tumor resected using non-exposed endoscopic wall-inversion surgery. ( 29039113 )
2017
24
Subungual onychomycosis due to<i>Aspergillus niger</i>mimicking a glomus tumor: A case report. ( 29188057 )
2017
25
Glomus Tumor in the Tarsal Tunnel: A Case Report. ( 28633794 )
2017
26
Glomus Tumor of the Toe. ( 28650755 )
2017
27
Glomus Tumor of the Scrotum: A Case Report and Mini-Review. ( 29234266 )
2017
28
A blue middle ear mass: Cholesterol granuloma mimicking a glomus tumor and endolymphatic sac tumor. ( 27931523 )
2017
29
Unusual Volar Pulp Location of Glomus Tumor. ( 28203512 )
2017
30
Glomus Tumor of the Larynx: A Rare Synchronous Paraganglioma in a Patient with Bilateral Carotid Body Tumor Detected on (68)Ga-DOTANOC PET/CT. ( 28680217 )
2017
31
Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. ( 28438258 )
2017
32
Intra-Articular Glomus Tumor- A Rare Presentation. ( 28272676 )
2017
33
Malignant Glomus Tumor of the Kidney. ( 28262221 )
2017
34
Glomus Tumor of the Neck Detected With 99mTc EDDA HYNIC-TOC. ( 28806247 )
2017
35
Glomus Tumor of the Sciatic Nerve: An Extraspinal Cause of Sciatica. ( 28934536 )
2017
36
An Extradigital Glomus Tumor of the Median Antebrachial Vein. ( 28888573 )
2017
37
Long-term survival case of malignant glomus tumor mimicking "dumbbell-shaped" neurogenic tumor. ( 27421277 )
2016
38
Glomus Tumor Excision With Clitoral Preservation. ( 27015262 )
2016
39
Intravascular extra-digital glomus tumor of the forearm. ( 27421300 )
2016
40
Gastric glomus tumor. ( 27887020 )
2016
41
Glomus Tumor of the Stomach: GI Image. ( 27844265 )
2016
42
Extradigital Glomus Tumor Revisited: Painful Subcutaneous Nodules Located in Various Parts of the Body. ( 26955123 )
2016
43
Malignant Glomus Tumor of the Kidney: A Case Report and Review of the Literature. ( 27349133 )
2016
44
Extradigital glomus tumor: a rare etiology for wrist soft tissue mass. ( 27594949 )
2016
45
Giant subungual glomus tumor: clinical, dermoscopy, imagiologic and surgery details. ( 28329592 )
2016
46
Subungual Glomus Tumor. ( 27556243 )
2016
47
Sonographic diagnosis of a glomus tumor of the thigh. ( 27444193 )
2016
48
Glomangiopericytoma and glomus tumor of the sinonasal tract: A report of two cases with emphasis on the differential diagnosis. ( 26972077 )
2016
49
A Rare Case of Glomus Tumor of the Great Toe: An Analysis of Behavior at This Rare Site. ( 26864831 )
2016
50
An extremely rare case of a glomus tumor in the popliteal fossa. ( 27408511 )
2016

Variations for Glomus Tumor

Expression for Glomus Tumor

Search GEO for disease gene expression data for Glomus Tumor.

Pathways for Glomus Tumor

GO Terms for Glomus Tumor

Cellular components related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuromuscular junction GO:0031594 8.96 DES SYP
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHB SDHD

Biological processes related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.16 SDHB SDHD
2 intermediate filament organization GO:0045109 8.96 DES VIM
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 8.96 SDHB SDHD
2 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHB SDHD

Sources for Glomus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....