MCID: GLM008
MIFTS: 59

Glomus Tumor malady

Cancer diseases, Rare diseases categories
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Summaries for Glomus Tumor

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards: Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and neurofibromatosis. An important gene associated with Glomus Tumor is DES (desmin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoplasmic microtubules. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related mouse phenotypes are digestive/alimentary and craniofacial.

Wikipedia:65 A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\" or glomangioma) is a... more...

Aliases & Classifications for Glomus Tumor

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8Disease Ontology, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
glomus tumor:
Age of onset: Variable


Aliases & Descriptions:

glomus tumor 8 45 49 62
glomus neoplasm 8
glomus tumour 8


External Ids:

Disease Ontology8 DOID:2431
NCIt40 C3060
MeSH35 D005918

Related Diseases for Glomus Tumor

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1glomangioma31.2GLMN
2neurofibromatosis30.8NF1, SDHD, SDHB
3hemangiopericytoma30.6S100B, S100A1, ACTC1, MUC1, VIM, NGFR
4paraganglioma30.3NF1, S100B, S100A1, VHL, SYP, SDHAF2
5leiomyosarcoma30.3DES, VIM, MUC1, ACTC1, S100A1, S100B
6hidradenoma30.3MUC1
7chondroma30.3SDHB, SDHD
8carotid body tumor30.2SDHB, SDHD
9hemangioma30.2KRIT1, NF1, VHL, ACTC1, SDHAF2, SDHD
10glomuvenous malformation30.2KRIT1, GLMN
11merkel cell carcinoma30.2MUC1, SYP
12pleomorphic adenoma30.2DES, VIM, MUC1, ACTC1, S100A1, S100B
13multiple endocrine neoplasia30.1NF1, VHL, SDHD, SDHB
14dermatofibrosarcoma protuberans30.1S100B, S100A1, ACTC1, MUC1, VIM, DES
15gastrointestinal stromal tumor30.0NF1, S100B, S100A1, ACTC1, VIM, SDHB
16adenoma30.0BRAF, MUC1, ACTC1, SYP, VHL, S100A1
17neurofibroma30.0VIM, NGFR, MUC1, ACTC1, SYP, NF1
18subungual glomus tumor10.8
19glomangiosarcoma10.5
20glomus jugulare tumors10.4
21skin glomus tumor10.4
22glomangiomyoma10.3
23mediastinitis10.3
24vaginitis10.2
25infantile myofibromatosis10.1DES
26adenomatoid tumor10.1VIM
27kidney cancer10.1VHL
28nephrogenic adenoma10.1S100A1
29fasciitis10.1ACTC1
30melanotic neuroectodermal tumor10.1SYP
31cavernous hemangioma10.1KRIT1
32carney triad10.1SDHB, SDHD
33phaeochromocytoma10.1SDHD, SDHB
34paraganglioma and gastric stromal sarcoma10.1SDHB, SDHD
35leiomyomatosis10.1VHL, SDHB
36malignant peripheral nerve sheath tumor10.1NF1
37desmoid tumor10.1ACTC1, DES
38alveolar soft part sarcoma10.1DES, VIM
39cystadenocarcinoma10.1MUC1
40adenosarcoma10.1DES, ACTC1
41rosai-dorfman disease10.1S100B
42desmoplastic small round cell tumor10.1MUC1, DES
43papilloma10.1ACTC1, CDKN2B
44langerhans-cell histiocytosis10.1S100B, S100A1
45clear cell ependymoma10.1MUC1, VIM
46ganglioglioma10.1S100B, SYP
47papillary ependymoma10.1SYP, S100B
48epithelioid leiomyosarcoma10.1ACTC1, VIM, DES
49pseudosarcomatous fibromatosis10.1DES, VIM, ACTC1
50neurilemmoma10.1NF1

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to glomus tumor

Symptoms for Glomus Tumor

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Drugs & Therapeutics for Glomus Tumor

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Glomus Tumor

Search NIH Clinical Center for Glomus Tumor

Genetic Tests for Glomus Tumor

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Anatomical Context for Glomus Tumor

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33MalaCards
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MalaCards organs/tissues related to Glomus Tumor:

33
Smooth muscle, Trachea, Kidney, Bone, Ovary, Tongue, Breast, Lung, Liver, Lymph node, Skin, Testes, Colon, Uterus, Cervix, Endothelial, Spinal cord

Animal Models for Glomus Tumor or affiliated genes

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37MGI
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Publications for Glomus Tumor

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Sources:
52PubMed
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Articles related to Glomus Tumor:

(show top 50)    (show all 462)
idTitleAuthorsYear
1
Tracheal glomus tumor: two cases with bronchoscopic intervention. (24384448)
2014
2
A rare large tracheal glomus tumor with postoperative haematemesis. (24255789)
2013
3
Glomus tumor of the cheek: a case report. (22811718)
2012
4
Treatment of recurrent glomus tumor using Mohs surgery. (22136509)
2012
5
Glomus Tumor Presenting as Raynaud's Phenomenon. (22811722)
2012
6
Percutaneous radiofrequency ablation of primary intraosseous spinal glomus tumor. (22072240)
2012
7
A new case of lower extremity glomus tumor up-to date review and case report. (22802895)
2012
8
Symplastic glomus tumor. (22788825)
2012
9
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
10
Large glomus tumor presenting in a 9-year-old. (21493250)
2011
11
Primary glomus tumor of the liver: a rare case report and review of the literature. (21934228)
2011
12
Glomus tumor of the ovary: a case report. (20667926)
2010
13
A glomus tumor anterior to the patellar tendon: a case report. (21088468)
2010
14
Glomus tumor of the hip. An unusual location. (19198725)
2009
15
Glomus tumor of the breast: first report. (18446361)
2009
16
Glomus tumor of the toe with symptoms similar to those of Morton's disease. (19997833)
2009
17
Intraosseous glomus tumor of the great toe: a case report with review of the literature. (18590892)
2008
18
Intraorbital and intracranial soft-tissue glomus tumor in an 8-year-old child. Case report. (18447675)
2008
19
Glomus tumor. (18788860)
2008
20
Glomus tumor of the ampulla. (17521650)
2007
21
A clinicopathologic study of glomus tumor of the stomach. (16940885)
2006
22
Glomangiomyoma (glomus tumor) of the kidney. (16119994)
2005
23
Extradigital glomus tumor of the triceps tendon as a cause of elbow pain: a case report. (12934039)
2003
24
Ultrasound pattern of glomus tumor of the shoulder. (12589272)
2002
25
Glomus tumor of the trachea. (11515904)
2001
26
An additional case of solitary subungual glomus tumor associated with neurofibromatosis 1. (10920593)
2000
27
Multiple glomus tumor: a case report and review of the literature. (10517474)
1999
28
Malignant glomus tumor. A case report of widespread metastases in a patient with multiple glomus body hamartomas. (8554113)
1996
29
Glomus tumor of the upper lip. (7674003)
1995
30
Radiologic case study. Glomus tumor. (7479417)
1995
31
Extradigital glomus tumor as a cause of knee pain. (8248416)
1993
32
Subungual glomus tumor: diagnosis based on high-resolution MR images. (1332458)
1992
33
Congenital arterial anomaly in the middle ear presenting as a glomus tumor. (1487462)
1992
34
Mantle zone lymphoma in a gastric glomus tumor. (1327492)
1992
35
Intraosseous glomus tumor in the upper thoracic spine complicating compression myelopathy. A case report. (1658951)
1991
36
Intraosseous glomus tumor: report of a case and review of the literature. (3019113)
1986
37
A case report of glomus tumor of the stomach. (6330409)
1984
38
Glomus tumor (golomangioma) of the tongue. A light and electron microscopic study. (6270610)
1981
39
Glomus tumor of the digits. (197147)
1977
40
Glomus tumor of the stomach--a case report]. (185440)
1976
41
Glomus tumor or glomangioma in podiatric medicine. (168245)
1975
42
A multifocal diffuse glomus tumor: case report and review of the literature. (4334060)
1972
43
Glomangioma (glomus tumor): report of case with 50-year history. (4326125)
1971
44
Subungual glomus tumor. Radiological manifestations. (4322892)
1970
45
Glomus tumor of the stomach. (14002266)
1962
46
Hemangiopericytoma (glomus tumor) of the mediastinum; review of the literature and report of case. (13187186)
1954
47
Subungual glomus tumor; report of a case. (18890423)
1948
48
Case of glomus tumor. (20241073)
1947
49
The glomus tumor. (20983245)
1945
50
Neuromyoarterial Glomus Tumor in the Eyelid. (16693240)
1940

Variations for Glomus Tumor

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Expression for genes affiliated with Glomus Tumor

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glomus Tumor

Search GEO for disease gene expression data for Glomus Tumor.

Pathways for genes affiliated with Glomus Tumor

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 60Thomson Reuters, 5Cell Signaling Technology, 55Reactome, 54R&D Systems, 53QIAGEN
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Pathways related to Glomus Tumor according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.7DES, ACTG1, ACTC1
2
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.6ACTG1, VIM, DES
39.5ACTC1, ACTG1, VIM, DES
4
Show member pathways
9.5ACTC1, ACTG1, VIM, DES
5
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection38
9.4ACTC1, ACTG1, BRAF
69.3S100B, VHL, SYP, NGFR
79.3BRAF, VHL, KRAS
8
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.2BRAF, KRAS, CDKN2B
9
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.2KRAS, MUC1, BRAF
109.0BRAF, VHL, KRAS, CDKN2B
118.9KRAS, NF1, BRAF
12
Show member pathways
Signaling Pathways in Glioblastoma38
8.6BRAF, NF1, KRAS, CDKN2B
13
Show member pathways
7.7NGFR, BRAF, ACTG1, NF1, KRAS, KRIT1
14
Show member pathways
7.3CDKN2B, DES, NGFR, BRAF, VIM, MUC1

Compounds for genes affiliated with Glomus Tumor

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Glomus Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1orcein4510.0DES, VIM, ACTC1, S100B
2eosin459.9VIM, MUC1, S100B
3fumarate45 1110.7VHL, SDHD, SDHB
4ganglioside459.6DES, NGFR, VIM, SYP
5s 100459.5DES, VIM, MUC1, ACTC1, SYP, S100B
62-methoxyethanol459.5S100A1, ACTC1, VIM
7reticulin459.5DES, VIM, MUC1, ACTC1, SYP, S100B
8succinate459.5SDHB, SDHD, VHL, NF1
9dbc-amp459.4NGFR, VIM, SYP, S100B
10toluidine459.4S100A1, VIM, DES
11catecholamine459.3NGFR, SDHB, SDHD, VIM, SYP, S100B
12gold459.2DES, BRAF, MUC1, SYP, KRIT1
13actomyosin459.2VIM, ACTC1, S100A1, KRIT1
14ethanol45 51 24 1112.2DES, NGFR, SDHB, MUC1, SYP, S100B
15creatinine459.2DES, SDHB, VIM, MUC1, ACTC1, SYP
16biotin45 24 1111.1DES, VIM, MUC1, ACTC1, S100A1
17formaldehyde45 2410.1DES, VIM, MUC1, ACTC1, SYP, S100B
18nmda45 2910.1KRIT1, SYP, VIM, SDHB, NGFR
19imatinib45 51 1111.1DES, BRAF, ACTC1, S100B, KRAS
20matrigel458.9NGFR, BRAF, VIM, MUC1, ACTC1
2112-o-tetradecanoylphorbol 13-acetate458.9DES, NGFR, BRAF, VIM, MUC1
22testosterone45 61 24 1111.9DES, SDHB, VIM, MUC1, ACTC1, SYP
23acetylcholine45 51 29 24 1112.7DES, NGFR, VIM, SYP, S100A1, S100B
24b 723458.7VIM, MUC1, ACTC1, SYP, S100A1, S100B
25mucicarmine458.6S100B, DES, VIM, MUC1, ACTC1, SYP
26methionine458.5DES, VIM, S100B, NF1, KRIT1
27iron45 249.5DES, SDHB, SDHD, VIM, ACTC1, VHL
28dexamethasone45 51 29 1111.5NGFR, VIM, MUC1, ACTG1, ACTC1, SYP
29rapamycin458.5BRAF, VIM, VHL, NF1, GLMN, KRAS
30glutamate458.5NGFR, SDHB, BRAF, VIM, SYP, S100B
31glucose458.4DES, NGFR, SDHB, BRAF, MUC1, ACTC1
32oxygen45 249.4DES, NGFR, SDHB, SDHD, MUC1, ACTC1
33threonine458.4DES, NGFR, BRAF, MUC1, S100B, KRIT1
34arginine458.3DES, SDHB, BRAF, VIM, S100B, NF1
35hematoxylin458.3DES, NGFR, VIM, MUC1, ACTC1, SYP
36gtp45 299.3BRAF, SYP, S100B, NF1, KRAS, KRIT1
37forskolin45 51 1110.3NGFR, BRAF, VIM, MUC1, SYP, S100B
38glycogen45 249.2DES, SDHB, VIM, MUC1, ACTC1, SYP
39nitric oxide45 24 1110.0DES, NGFR, MUC1, SYP, VHL, S100A1
40cyclic amp45 248.8DES, NGFR, BRAF, VIM, MUC1, SYP
41vegf457.6DES, NGFR, SDHB, BRAF, VIM, MUC1
42lipid457.6NGFR, SDHB, BRAF, VIM, MUC1, SYP
43cysteine457.2DES, NGFR, SDHB, VIM, MUC1, SYP
44progesterone45 29 61 24 1111.1DES, NGFR, BRAF, VIM, MUC1, ACTC1
45serine456.8DES, NGFR, BRAF, VIM, MUC1, SYP
46paraffin456.7DES, NGFR, BRAF, VIM, MUC1, ACTC1
47retinoic acid45 247.4DES, NGFR, BRAF, VIM, MUC1, ACTC1
48calcium45 51 24 119.1MUC1, BRAF, SDHB, NGFR, DES, ACTG1
49tyrosine455.8ACTC1, MUC1, BRAF, SDHB, NGFR, DES
50estrogen455.8VIM, MUC1, ACTC1, SYP, VHL, S100A1

GO Terms for genes affiliated with Glomus Tumor

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16Gene Ontology
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Cellular components related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057499.8SDHD, SDHB
2cytosolGO:0058298.0NGFR, BRAF, VIM, ACTG1, ACTC1, VHL

Biological processes related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of neuronal synaptic plasticityGO:0481689.9S100B, SYP
2muscle filament slidingGO:0300499.8DES, VIM, ACTC1
3regulation of long-term neuronal synaptic plasticityGO:0481699.2KRAS, NF1, SYP
4regulation of synaptic transmission, GABAergicGO:0322289.1KRAS, NF1

Molecular functions related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:04803910.0SDHD, SDHB
2structural constituent of cytoskeletonGO:0052009.4DES, VIM, ACTG1
3S100 protein bindingGO:0445489.3S100B, S100A1
4identical protein bindingGO:0428027.8DES, BRAF, VIM, ACTG1, SYP, S100A1
5protein bindingGO:0055154.7CDKN2B, DES, NGFR, SDHB, SDHAF2, BRAF

Products for genes affiliated with Glomus Tumor

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Sources for Glomus Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet