MCID: GLM008
MIFTS: 51

Glomus Tumor malady

Cancer diseases, Rare diseases categories

Summaries for Glomus Tumor

About this section


Disease Ontology:9 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards based summary: Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and paragangliomas 1, with or without deafness. An important gene associated with Glomus Tumor is DES (desmin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoplasmic microtubules. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related mouse phenotypes are digestive/alimentary and craniofacial.

Wikipedia:63 A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\" or glomangioma) is a... more...

Aliases & Classifications for Glomus Tumor

About this section
Sources:
9Disease Ontology, 43Novoseek, 47Orphanet, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt
See all sources

Glomus Tumor, Aliases & Descriptions:

Name: Glomus Tumor 9 43 47 60
Glomus Neoplasm 9
 
Glomus Tumour 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
glomus tumor:
Age of onset: All ages


External Ids:

Disease Ontology9 DOID:2431
MeSH33 D005918
NCIt38 C3060
Orphanet47 391651

Related Diseases for Glomus Tumor

About this section

Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1glomangioma31.9GLMN
2paragangliomas 1, with or without deafness31.2SDHB, SDHD
3glomuvenous malformations30.9GLMN, KRIT1
4hidradenoma30.8MUC1
5chondroma30.8SDHD, SDHB
6hereditary paraganglioma-pheochromocytoma syndromes30.7SDHD, SDHB, SDHAF2
7merkel cell carcinoma30.6MUC1, SYP
8neurofibromatosis30.6SDHD, SDHB, VHL, KRAS, NF1
9hemangiopericytoma30.5S100B, S100A1, ACTC1, MUC1, VIM, NGFR
10leiomyosarcoma30.4DES, VIM, MUC1, ACTC1, S100A1, S100B
11multiple endocrine neoplasia30.4NF1, VHL, SDHB, SDHD
12pleomorphic adenoma30.2S100B, S100A1, ACTC1, MUC1, DES, VIM
13dermatofibrosarcoma protuberans30.2DES, VIM, S100B, S100A1, ACTC1, MUC1
14paraganglioma30.1SDHB, SDHD, SDHAF2, SYP, VHL, S100A1
15hemangioma30.1SDHB, SDHD, SDHAF2, ACTC1, VHL, NF1
16gastrointestinal stromal tumor29.9NF1, DES, SDHB, VIM, ACTC1, S100A1
17neurofibroma29.6ACTC1, MUC1, VIM, NGFR, SYP, S100A1
18adenoma29.5SYP, MUC1, VHL, S100A1, BRAF, ACTC1
19subungual glomus tumor10.8
20infantile myofibromatosis10.6DES
21adenomatoid tumor10.6VIM
22renal cell carcinoma10.6VHL
23fasciitis10.6ACTC1
24nephrogenic adenoma10.6S100A1
25melanotic neuroectodermal tumor10.5SYP
26cavernous hemangioma10.5KRIT1
27carney triad10.5SDHB, SDHD
28glomangiosarcoma10.5
29phaeochromocytoma10.5SDHB, SDHD
30paraganglioma and gastric stromal sarcoma10.5SDHD, SDHB
31leiomyomatosis10.5SDHB, VHL
32malignant peripheral nerve sheath tumor10.5NF1
33desmoid disease, hereditary10.5DES, ACTC1
34cystadenocarcinoma10.5MUC1
35alveolar soft-part sarcoma10.5DES, VIM
36adenosarcoma10.4DES, ACTC1
37rosai-dorfman disease10.4S100B
38desmoplastic small round cell tumor10.4MUC1, DES
39papilloma10.4ACTC1, CDKN2B
40langerhans-cell histiocytosis10.4S100B, S100A1
41clear cell ependymoma10.4MUC1, VIM
42dysembryoplastic neuroepithelial tumor10.4SYP
43skin glomus tumor10.4
44ganglioglioma10.4SYP, S100B
45papillary ependymoma10.4S100B, SYP
46epithelioid leiomyosarcoma10.4DES, ACTC1, VIM
47pseudosarcomatous fibromatosis10.4VIM, ACTC1, DES
48neurilemmoma10.4NF1
49endometrial stromal sarcoma10.4ACTC1, DES, VIM
50subependymal giant cell astrocytoma10.4SYP, S100B

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to glomus tumor

Symptoms for Glomus Tumor

About this section

Drugs & Therapeutics for Glomus Tumor

About this section

Drug clinical trials:

Search ClinicalTrials for Glomus Tumor

Search NIH Clinical Center for Glomus Tumor

Genetic Tests for Glomus Tumor

About this section

Anatomical Context for Glomus Tumor

About this section

MalaCards organs/tissues related to Glomus Tumor:

31
Smooth muscle, Trachea, Kidney, Bone, Ovary, Liver, Lung, Breast, Tongue, Lymph node, Colon, Skin, Testes, Spinal cord, Uterus, Cervix, Endothelial

Animal Models for Glomus Tumor or affiliated genes

About this section

Publications for Glomus Tumor

About this section

Articles related to Glomus Tumor:

(show top 50)    (show all 470)
idTitleAuthorsYear
1
Tracheal glomus tumor: two cases with bronchoscopic intervention. (24384448)
2014
2
A rare large tracheal glomus tumor with postoperative haematemesis. (24255789)
2013
3
Glomus tumor of the cheek: a case report. (22811718)
2012
4
Treatment of recurrent glomus tumor using Mohs surgery. (22136509)
2012
5
Glomus Tumor Presenting as Raynaud's Phenomenon. (22811722)
2012
6
Percutaneous radiofrequency ablation of primary intraosseous spinal glomus tumor. (22072240)
2012
7
A new case of lower extremity glomus tumor up-to date review and case report. (22802895)
2012
8
Symplastic glomus tumor. (22788825)
2012
9
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
10
Large glomus tumor presenting in a 9-year-old. (21493250)
2011
11
Primary glomus tumor of the liver: a rare case report and review of the literature. (21934228)
2011
12
Glomus tumor of the ovary: a case report. (20667926)
2010
13
A glomus tumor anterior to the patellar tendon: a case report. (21088468)
2010
14
Glomus tumor of the hip. An unusual location. (19198725)
2009
15
Glomus tumor of the breast: first report. (18446361)
2009
16
Glomus tumor of the toe with symptoms similar to those of Morton's disease. (19997833)
2009
17
Intraosseous glomus tumor of the great toe: a case report with review of the literature. (18590892)
2008
18
Intraorbital and intracranial soft-tissue glomus tumor in an 8-year-old child. Case report. (18447675)
2008
19
Glomus tumor. (18788860)
2008
20
Glomus tumor of the ampulla. (17521650)
2007
21
A clinicopathologic study of glomus tumor of the stomach. (16940885)
2006
22
Glomangiomyoma (glomus tumor) of the kidney. (16119994)
2005
23
Extradigital glomus tumor of the triceps tendon as a cause of elbow pain: a case report. (12934039)
2003
24
Ultrasound pattern of glomus tumor of the shoulder. (12589272)
2002
25
Glomus tumor of the trachea. (11515904)
2001
26
An additional case of solitary subungual glomus tumor associated with neurofibromatosis 1. (10920593)
2000
27
Multiple glomus tumor: a case report and review of the literature. (10517474)
1999
28
Glomus tumor of the fat pad. (9586981)
1998
29
Malignant glomus tumor. A case report of widespread metastases in a patient with multiple glomus body hamartomas. (8554113)
1996
30
Glomus tumor of the upper lip. (7674003)
1995
31
Radiologic case study. Glomus tumor. (7479417)
1995
32
Extradigital glomus tumor as a cause of knee pain. (8248416)
1993
33
Subungual glomus tumor: diagnosis based on high-resolution MR images. (1332458)
1992
34
Congenital arterial anomaly in the middle ear presenting as a glomus tumor. (1487462)
1992
35
Mantle zone lymphoma in a gastric glomus tumor. (1327492)
1992
36
Intraosseous glomus tumor in the upper thoracic spine complicating compression myelopathy. A case report. (1658951)
1991
37
Intraosseous glomus tumor: report of a case and review of the literature. (3019113)
1986
38
A case report of glomus tumor of the stomach. (6330409)
1984
39
Glomus tumor (golomangioma) of the tongue. A light and electron microscopic study. (6270610)
1981
40
Glomus tumor of the digits. (197147)
1977
41
Glomus tumor of the stomach--a case report]. (185440)
1976
42
Glomus tumor or glomangioma in podiatric medicine. (168245)
1975
43
A multifocal diffuse glomus tumor: case report and review of the literature. (4334060)
1972
44
Glomangioma (glomus tumor): report of case with 50-year history. (4326125)
1971
45
Subungual glomus tumor. Radiological manifestations. (4322892)
1970
46
Glomus tumor of the stomach. (14002266)
1962
47
Subungual glomus tumor; report of a case. (18890423)
1948
48
Case of glomus tumor. (20241073)
1947
49
The glomus tumor. (20983245)
1945
50
Neuromyoarterial Glomus Tumor in the Eyelid. (16693240)
1940

Variations for Glomus Tumor

About this section

Expression for genes affiliated with Glomus Tumor

About this section
Search GEO for disease gene expression data for Glomus Tumor.

Pathways for genes affiliated with Glomus Tumor

About this section

Pathways related to Glomus Tumor according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.7DES, ACTG1, ACTC1
29.5ACTC1, ACTG1, VIM, DES
3
Show member pathways
9.5ACTC1, ACTG1, VIM, DES
4
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion58
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
9.4ACTC1, ACTG1, BRAF
59.3S100B, VHL, SYP, NGFR
69.3BRAF, VHL, KRAS
7
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.2BRAF, KRAS, CDKN2B
8
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.2KRAS, MUC1, BRAF
99.0BRAF, VHL, KRAS, CDKN2B
108.9KRAS, NF1, BRAF
11
Show member pathways
Signaling Pathways in Glioblastoma36
8.6BRAF, NF1, KRAS, CDKN2B
12
Show member pathways
7.7NGFR, BRAF, ACTG1, NF1, KRAS, KRIT1
13
Show member pathways
7.3CDKN2B, DES, NGFR, BRAF, VIM, MUC1

Compounds for genes affiliated with Glomus Tumor

About this section

Compounds related to Glomus Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1orcein4310.0ACTC1, VIM, S100B, DES
2eosin439.9VIM, S100B, MUC1
3fumarate43 1210.7SDHD, VHL, SDHB
4ganglioside439.6DES, NGFR, SYP, VIM
52-methoxyethanol439.5ACTC1, S100A1, VIM
6s 100439.5SYP, VIM, S100B, ACTC1, MUC1, DES
7reticulin439.5MUC1, ACTC1, VIM, SYP, S100B, DES
8succinate439.5VHL, NF1, SDHB, SDHD
9dbc-amp439.4S100B, SYP, VIM, NGFR
10toluidine439.4VIM, DES, S100A1
11catecholamine439.3NGFR, S100B, SDHB, VIM, SYP, SDHD
12gold439.2MUC1, SYP, BRAF, KRIT1, DES
13actomyosin439.2VIM, KRIT1, S100A1, ACTC1
14ethanol43 49 24 1212.2SYP, MUC1, SDHB, DES, NGFR, S100B
15creatinine439.2MUC1, ACTC1, SYP, S100B, VIM, SDHB
16biotin43 24 1211.1S100A1, VIM, DES, ACTC1, MUC1
17formaldehyde43 2410.1KRIT1, SYP, MUC1, VIM, ACTC1, DES
18nmda43 2810.1SYP, VIM, NGFR, KRIT1, SDHB
19imatinib43 49 1211.1KRAS, S100B, BRAF, DES, ACTC1
20matrigel438.9NGFR, BRAF, VIM, MUC1, ACTC1
2112-o-tetradecanoylphorbol 13-acetate438.9MUC1, VIM, BRAF, NGFR, DES
22testosterone43 59 24 1211.9SDHB, KRIT1, DES, S100B, VIM, ACTC1
23b 723438.7DES, SYP, VIM, MUC1, ACTC1, S100A1
24acetylcholine43 49 28 24 1212.7NGFR, DES, VIM, S100A1, S100B, SYP
25mucicarmine438.6DES, VIM, S100B, S100A1, SYP, ACTC1
26methionine438.5VIM, NF1, KRIT1, DES, S100B
27iron43 249.5VIM, DES, S100B, ACTC1, SDHB, SDHD
28dexamethasone43 49 28 1211.5S100B, SYP, ACTG1, KRIT1, MUC1, VIM
29rapamycin438.5BRAF, VIM, GLMN, NF1, KRAS, VHL
30glutamate438.5VIM, S100B, KRIT1, BRAF, SDHB, SYP
31glucose438.4BRAF, DES, MUC1, ACTC1, VHL, S100B
32oxygen43 249.4DES, NGFR, MUC1, SDHB, SDHD, ACTC1
33threonine438.4MUC1, BRAF, DES, NGFR, S100B, KRIT1
34arginine438.3KRIT1, NF1, S100B, VIM, BRAF, DES
35hematoxylin438.3DES, NGFR, VIM, MUC1, ACTC1, SYP
36gtp43 289.3BRAF, SYP, S100B, NF1, KRAS, KRIT1
37forskolin43 49 1210.3MUC1, SYP, S100B, NF1, NGFR, VIM
38glycogen43 249.2VHL, SYP, ACTC1, MUC1, S100B, VIM
39nitric oxide43 24 1210.0S100A1, KRIT1, NGFR, MUC1, SYP, VHL
40cyclic amp43 248.8BRAF, NGFR, MUC1, KRIT1, NF1, S100B
41vegf437.6VIM, KRAS, S100B, VHL, BRAF, SYP
42lipid437.6NF1, NGFR, SDHB, BRAF, VIM, SYP
43cysteine437.2S100B, NF1, KRIT1, MUC1, VIM, NGFR
44progesterone43 28 59 24 1211.1S100B, NF1, NGFR, BRAF, S100A1, VIM
45serine436.8NGFR, CDKN2B, KRIT1, KRAS, NF1, DES
46paraffin436.7NGFR, BRAF, VIM, MUC1, ACTC1, SYP
47retinoic acid43 247.4DES, CDKN2B, KRAS, NF1, S100B, S100A1
48calcium43 49 24 129.1S100A1, DES, BRAF, ACTG1, MUC1, SYP
49tyrosine435.8SDHB, KRIT1, SYP, DES, S100B, CDKN2B
50estrogen435.8SYP, ACTC1, MUC1, VIM, BRAF, NGFR

GO Terms for genes affiliated with Glomus Tumor

About this section

Cellular components related to Glomus Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:00057499.8SDHD, SDHB
2cytosolGO:00058298.0NGFR, BRAF, VIM, ACTG1, ACTC1, VHL

Biological processes related to Glomus Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of neuronal synaptic plasticityGO:00481689.9S100B, SYP
2muscle filament slidingGO:00300499.8DES, VIM, ACTC1
3regulation of long-term neuronal synaptic plasticityGO:00481699.2KRAS, NF1, SYP
4regulation of synaptic transmission, GABAergicGO:00322289.1KRAS, NF1

Molecular functions related to Glomus Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:004803910.0SDHD, SDHB
2structural constituent of cytoskeletonGO:00052009.4DES, VIM, ACTG1
3S100 protein bindingGO:00445489.3S100B, S100A1
4identical protein bindingGO:00428027.8DES, BRAF, VIM, ACTG1, SYP, S100A1
5protein bindingGO:00055154.7CDKN2B, DES, NGFR, SDHB, SDHAF2, BRAF

Products for genes affiliated with Glomus Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Glomus Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet