MCID: GLM008
MIFTS: 51

Glomus Tumor malady

Cancer diseases, Rare diseases categories

Aliases & Classifications for Glomus Tumor

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Sources:
8Disease Ontology, 44Novoseek, 48Orphanet, 61UMLS, 33MeSH, 56SNOMED-CT, 39NCIt
See all sources

Aliases & Descriptions for Glomus Tumor:

Name: Glomus Tumor 8 44 48 61
Glomus Neoplasm 8
 
Glomus Tumour 8


Classifications:

Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
glomus tumor:
Age of onset: All ages


External Ids:

Disease Ontology8 DOID:2431
MeSH33 D005918
NCIt39 C3060
Orphanet48 391651

Summaries for Glomus Tumor

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Disease Ontology:8 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards based summary: Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and paragangliomas 1, with or without deafness. An important gene associated with Glomus Tumor is DES (desmin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoplasmic microtubules. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related mouse phenotypes are digestive/alimentary and craniofacial.

Wikipedia:64 A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\" or glomangioma) is a... more...

Related Diseases for Glomus Tumor

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Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1glomangioma31.9GLMN
2paragangliomas 1, with or without deafness31.2SDHB, SDHD
3glomuvenous malformations30.9GLMN, KRIT1
4hidradenoma30.8MUC1
5chondroma30.8SDHD, SDHB
6hereditary paraganglioma-pheochromocytoma syndromes30.7SDHD, SDHB, SDHAF2
7merkel cell carcinoma30.6MUC1, SYP
8neurofibromatosis30.6SDHD, SDHB, VHL, KRAS, NF1
9hemangiopericytoma30.5S100B, S100A1, ACTC1, MUC1, VIM, NGFR
10leiomyosarcoma30.4DES, VIM, MUC1, ACTC1, S100A1, S100B
11multiple endocrine neoplasia30.4NF1, VHL, SDHB, SDHD
12pleomorphic adenoma30.2S100B, S100A1, ACTC1, MUC1, DES, VIM
13dermatofibrosarcoma protuberans30.2DES, VIM, S100B, S100A1, ACTC1, MUC1
14paraganglioma30.1SDHB, SDHD, SDHAF2, SYP, VHL, S100A1
15hemangioma30.1SDHB, SDHD, SDHAF2, ACTC1, VHL, NF1
16gastrointestinal stromal tumor29.9NF1, DES, SDHB, VIM, ACTC1, S100A1
17neurofibroma29.6ACTC1, MUC1, VIM, NGFR, SYP, S100A1
18adenoma29.5SYP, MUC1, VHL, S100A1, BRAF, ACTC1
19subungual glomus tumor10.8
20infantile myofibromatosis10.6DES
21adenomatoid tumor10.6VIM
22renal cell carcinoma10.6VHL
23fasciitis10.6ACTC1
24nephrogenic adenoma10.6S100A1
25melanotic neuroectodermal tumor10.5SYP
26cavernous hemangioma10.5KRIT1
27carney triad10.5SDHB, SDHD
28glomangiosarcoma10.5
29phaeochromocytoma10.5SDHB, SDHD
30paraganglioma and gastric stromal sarcoma10.5SDHD, SDHB
31leiomyomatosis10.5SDHB, VHL
32malignant peripheral nerve sheath tumor10.5NF1
33desmoid disease, hereditary10.5DES, ACTC1
34cystadenocarcinoma10.5MUC1
35alveolar soft-part sarcoma10.5DES, VIM
36adenosarcoma10.4DES, ACTC1
37rosai-dorfman disease10.4S100B
38desmoplastic small round cell tumor10.4MUC1, DES
39papilloma10.4ACTC1, CDKN2B
40langerhans-cell histiocytosis10.4S100B, S100A1
41clear cell ependymoma10.4MUC1, VIM
42dysembryoplastic neuroepithelial tumor10.4SYP
43skin glomus tumor10.4
44ganglioglioma10.4SYP, S100B
45papillary ependymoma10.4S100B, SYP
46epithelioid leiomyosarcoma10.4DES, ACTC1, VIM
47pseudosarcomatous fibromatosis10.4VIM, ACTC1, DES
48neurilemmoma10.4NF1
49endometrial stromal sarcoma10.4ACTC1, DES, VIM
50subependymal giant cell astrocytoma10.4SYP, S100B

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to glomus tumor

Symptoms for Glomus Tumor

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Drugs & Therapeutics for Glomus Tumor

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Drug clinical trials:

Search ClinicalTrials for Glomus Tumor

Search NIH Clinical Center for Glomus Tumor

Genetic Tests for Glomus Tumor

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Anatomical Context for Glomus Tumor

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MalaCards organs/tissues related to Glomus Tumor:

31
Smooth muscle, Trachea, Kidney, Bone, Ovary, Liver, Lung, Breast, Tongue, Lymph node, Colon, Skin, Testes, Spinal cord, Uterus, Cervix, Endothelial

Animal Models for Glomus Tumor or affiliated genes

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Publications for Glomus Tumor

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Articles related to Glomus Tumor:

(show top 50)    (show all 470)
idTitleAuthorsYear
1
Tracheal glomus tumor: two cases with bronchoscopic intervention. (24384448)
2014
2
A rare large tracheal glomus tumor with postoperative haematemesis. (24255789)
2013
3
Glomus tumor of the cheek: a case report. (22811718)
2012
4
Treatment of recurrent glomus tumor using Mohs surgery. (22136509)
2012
5
Glomus Tumor Presenting as Raynaud's Phenomenon. (22811722)
2012
6
Percutaneous radiofrequency ablation of primary intraosseous spinal glomus tumor. (22072240)
2012
7
A new case of lower extremity glomus tumor up-to date review and case report. (22802895)
2012
8
Symplastic glomus tumor. (22788825)
2012
9
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
10
Large glomus tumor presenting in a 9-year-old. (21493250)
2011
11
Primary glomus tumor of the liver: a rare case report and review of the literature. (21934228)
2011
12
Glomus tumor of the ovary: a case report. (20667926)
2010
13
A glomus tumor anterior to the patellar tendon: a case report. (21088468)
2010
14
Glomus tumor of the hip. An unusual location. (19198725)
2009
15
Glomus tumor of the breast: first report. (18446361)
2009
16
Glomus tumor of the toe with symptoms similar to those of Morton's disease. (19997833)
2009
17
Intraosseous glomus tumor of the great toe: a case report with review of the literature. (18590892)
2008
18
Intraorbital and intracranial soft-tissue glomus tumor in an 8-year-old child. Case report. (18447675)
2008
19
Glomus tumor. (18788860)
2008
20
Glomus tumor of the ampulla. (17521650)
2007
21
A clinicopathologic study of glomus tumor of the stomach. (16940885)
2006
22
Glomangiomyoma (glomus tumor) of the kidney. (16119994)
2005
23
Extradigital glomus tumor of the triceps tendon as a cause of elbow pain: a case report. (12934039)
2003
24
Ultrasound pattern of glomus tumor of the shoulder. (12589272)
2002
25
Glomus tumor of the trachea. (11515904)
2001
26
An additional case of solitary subungual glomus tumor associated with neurofibromatosis 1. (10920593)
2000
27
Multiple glomus tumor: a case report and review of the literature. (10517474)
1999
28
Glomus tumor of the fat pad. (9586981)
1998
29
Malignant glomus tumor. A case report of widespread metastases in a patient with multiple glomus body hamartomas. (8554113)
1996
30
Glomus tumor of the upper lip. (7674003)
1995
31
Radiologic case study. Glomus tumor. (7479417)
1995
32
Extradigital glomus tumor as a cause of knee pain. (8248416)
1993
33
Subungual glomus tumor: diagnosis based on high-resolution MR images. (1332458)
1992
34
Congenital arterial anomaly in the middle ear presenting as a glomus tumor. (1487462)
1992
35
Mantle zone lymphoma in a gastric glomus tumor. (1327492)
1992
36
Intraosseous glomus tumor in the upper thoracic spine complicating compression myelopathy. A case report. (1658951)
1991
37
Intraosseous glomus tumor: report of a case and review of the literature. (3019113)
1986
38
A case report of glomus tumor of the stomach. (6330409)
1984
39
Glomus tumor (golomangioma) of the tongue. A light and electron microscopic study. (6270610)
1981
40
Glomus tumor of the digits. (197147)
1977
41
Glomus tumor of the stomach--a case report]. (185440)
1976
42
Glomus tumor or glomangioma in podiatric medicine. (168245)
1975
43
A multifocal diffuse glomus tumor: case report and review of the literature. (4334060)
1972
44
Glomangioma (glomus tumor): report of case with 50-year history. (4326125)
1971
45
Subungual glomus tumor. Radiological manifestations. (4322892)
1970
46
Glomus tumor of the stomach. (14002266)
1962
47
Subungual glomus tumor; report of a case. (18890423)
1948
48
Case of glomus tumor. (20241073)
1947
49
The glomus tumor. (20983245)
1945
50
Neuromyoarterial Glomus Tumor in the Eyelid. (16693240)
1940

Variations for Glomus Tumor

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Expression for genes affiliated with Glomus Tumor

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Search GEO for disease gene expression data for Glomus Tumor.

Pathways for genes affiliated with Glomus Tumor

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Pathways related to Glomus Tumor according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.7DES, ACTG1, ACTC1
29.5ACTC1, ACTG1, VIM, DES
3
Show member pathways
9.5ACTC1, ACTG1, VIM, DES
4
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion59
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
9.4ACTC1, ACTG1, BRAF
59.3S100B, VHL, SYP, NGFR
69.3BRAF, VHL, KRAS
7
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.2BRAF, KRAS, CDKN2B
8
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
9.2KRAS, MUC1, BRAF
99.0BRAF, VHL, KRAS, CDKN2B
108.9KRAS, NF1, BRAF
11
Show member pathways
Signaling Pathways in Glioblastoma36
8.6BRAF, NF1, KRAS, CDKN2B
12
Show member pathways
7.7NGFR, BRAF, ACTG1, NF1, KRAS, KRIT1
13
Show member pathways
7.3CDKN2B, DES, NGFR, BRAF, VIM, MUC1

Compounds for genes affiliated with Glomus Tumor

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Compounds related to Glomus Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1orcein4410.0ACTC1, VIM, S100B, DES
2eosin449.9VIM, S100B, MUC1
3fumarate44 1110.7SDHD, VHL, SDHB
4ganglioside449.6DES, NGFR, SYP, VIM
52-methoxyethanol449.5ACTC1, S100A1, VIM
6s 100449.5SYP, VIM, S100B, ACTC1, MUC1, DES
7reticulin449.5MUC1, ACTC1, VIM, SYP, S100B, DES
8succinate449.5VHL, NF1, SDHB, SDHD
9dbc-amp449.4S100B, SYP, VIM, NGFR
10toluidine449.4VIM, DES, S100A1
11catecholamine449.3NGFR, S100B, SDHB, VIM, SYP, SDHD
12gold449.2MUC1, SYP, BRAF, KRIT1, DES
13actomyosin449.2VIM, KRIT1, S100A1, ACTC1
14ethanol44 50 24 1112.2SYP, MUC1, SDHB, DES, NGFR, S100B
15creatinine449.2MUC1, ACTC1, SYP, S100B, VIM, SDHB
16biotin44 24 1111.1S100A1, VIM, DES, ACTC1, MUC1
17formaldehyde44 2410.1KRIT1, SYP, MUC1, VIM, ACTC1, DES
18nmda44 2810.1SYP, VIM, NGFR, KRIT1, SDHB
19imatinib44 50 1111.1KRAS, S100B, BRAF, DES, ACTC1
20matrigel448.9NGFR, BRAF, VIM, MUC1, ACTC1
2112-o-tetradecanoylphorbol 13-acetate448.9MUC1, VIM, BRAF, NGFR, DES
22testosterone44 60 24 1111.9SDHB, KRIT1, DES, S100B, VIM, ACTC1
23b 723448.7DES, SYP, VIM, MUC1, ACTC1, S100A1
24acetylcholine44 50 28 24 1112.7NGFR, DES, VIM, S100A1, S100B, SYP
25mucicarmine448.6DES, VIM, S100B, S100A1, SYP, ACTC1
26methionine448.5VIM, NF1, KRIT1, DES, S100B
27iron44 249.5VIM, DES, S100B, ACTC1, SDHB, SDHD
28dexamethasone44 50 28 1111.5S100B, SYP, ACTG1, KRIT1, MUC1, VIM
29rapamycin448.5BRAF, VIM, GLMN, NF1, KRAS, VHL
30glutamate448.5VIM, S100B, KRIT1, BRAF, SDHB, SYP
31glucose448.4BRAF, DES, MUC1, ACTC1, VHL, S100B
32oxygen44 249.4DES, NGFR, MUC1, SDHB, SDHD, ACTC1
33threonine448.4MUC1, BRAF, DES, NGFR, S100B, KRIT1
34arginine448.3KRIT1, NF1, S100B, VIM, BRAF, DES
35hematoxylin448.3DES, NGFR, VIM, MUC1, ACTC1, SYP
36gtp44 289.3BRAF, SYP, S100B, NF1, KRAS, KRIT1
37forskolin44 50 1110.3MUC1, SYP, S100B, NF1, NGFR, VIM
38glycogen44 249.2VHL, SYP, ACTC1, MUC1, S100B, VIM
39nitric oxide44 24 1110.0S100A1, KRIT1, NGFR, MUC1, SYP, VHL
40cyclic amp44 248.8BRAF, NGFR, MUC1, KRIT1, NF1, S100B
41vegf447.6VIM, KRAS, S100B, VHL, BRAF, SYP
42lipid447.6NF1, NGFR, SDHB, BRAF, VIM, SYP
43cysteine447.2S100B, NF1, KRIT1, MUC1, VIM, NGFR
44progesterone44 28 60 24 1111.1S100B, NF1, NGFR, BRAF, S100A1, VIM
45serine446.8NGFR, CDKN2B, KRIT1, KRAS, NF1, DES
46paraffin446.7NGFR, BRAF, VIM, MUC1, ACTC1, SYP
47retinoic acid44 247.4DES, CDKN2B, KRAS, NF1, S100B, S100A1
48calcium44 50 24 119.1S100A1, DES, BRAF, ACTG1, MUC1, SYP
49tyrosine445.8SDHB, KRIT1, SYP, DES, S100B, CDKN2B
50estrogen445.8SYP, ACTC1, MUC1, VIM, BRAF, NGFR

GO Terms for genes affiliated with Glomus Tumor

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Cellular components related to Glomus Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:00057499.8SDHD, SDHB
2cytosolGO:00058298.0NGFR, BRAF, VIM, ACTG1, ACTC1, VHL

Biological processes related to Glomus Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of neuronal synaptic plasticityGO:00481689.9S100B, SYP
2muscle filament slidingGO:00300499.8DES, VIM, ACTC1
3regulation of long-term neuronal synaptic plasticityGO:00481699.2KRAS, NF1, SYP
4regulation of synaptic transmission, GABAergicGO:00322289.1KRAS, NF1

Molecular functions related to Glomus Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:004803910.0SDHD, SDHB
2structural constituent of cytoskeletonGO:00052009.4DES, VIM, ACTG1
3S100 protein bindingGO:00445489.3S100B, S100A1
4identical protein bindingGO:00428027.8DES, BRAF, VIM, ACTG1, SYP, S100A1
5protein bindingGO:00055154.7CDKN2B, DES, NGFR, SDHB, SDHAF2, BRAF

Sources for Glomus Tumor

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet