Glomus Tumor malady

Disease Ontology: A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.⁶

MalaCards: Glomus Tumor, also known as glomus tumor (morphologic abnormality), is related to glomangioma and glomuvenous malformations. An important gene associated with Glomus Tumor is CRTAC1 (cartilage acidic protein 1), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Hypertrophic cardiomyopathy (HCM). The compounds toluidine and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle and kidney, and related mouse phenotypes are normal and muscle.

Wikipedia: A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\" or glomangioma is a...⁴⁴ more...

Aliases & Descriptions:

glomus tumor 6 8 32 43 glomus tumor (morphologic abnormality) 6 glomus tumor (disorder) 6

glomus neoplasm 6 glomus tumour 6

Diseases related to glomus tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 338)

id	Related Disease	Score	Top Affiliating Genes
1	glomangioma	31.9	S100A1, GLMN, ACTC1, DES
2	glomuvenous malformations	31.8	GLMN, KRIT1
3	hereditary paraganglioma-pheochromocytoma syndromes	30.7	SDHAF2, SDHB, SDHD
4	carotid body tumor	29.4	SDHB, SDHD
5	glomangiomyoma	29.4	VIM, ACTC1, DES
6	nodular hidradenoma	28.6	VIM, MUC1
7	hidradenoma	28.1	VIM, MUC1
8	neurofibromatosis	27.6	VHL, SDHB, SDHD, S100B, NGFR
9	paraganglioma	26.6	VIM, VHL, SDHAF2, SDHB, SDHD, S100A1
10	vaginitis	26.5	VIM, MUC1, S100B, CALD1, ACTC1, DES
11	hemangiopericytoma	24.9	VIM, MUC1, S100A1, S100B, CD34, F8
12	lymph node palisaded myofibroblastoma	13.6	VIM, DES
13	myxosarcoma	13.6	VIM, DES
14	infantile digital fibromatosis	13.6	VIM, DES
15	prostate leiomyoma	13.6	VIM, DES
16	meninges sarcoma	13.6	VIM, DES
17	retroperitoneal leiomyosarcoma	13.5	S100A1, DES
18	intravenous leiomyomatosis	13.5	ACTC1, DES
19	venous malformations	13.5	GLMN, KRIT1
20	paraganglioma and gastric stromal sarcoma	13.5	SDHB, SDHD
21	cowden-like syndrome	13.5	SDHB, SDHD
22	hepatic angiomyolipoma	13.5	VIM, DES
23	orbit rhabdomyosarcoma	13.5	VIM, DES
24	endometrial stromal tumor	13.5	VIM, DES
25	pulmonary vein stenosis	13.5	ACTC1, DES
26	vhl-related pheochromocytoma	13.5	VHL, SDHB
27	alveolar soft part sarcoma	13.4	VIM, DES
28	mitochondrial complex ii deficiency	13.4	SDHB, SDHD
29	rhabdoid cancer	13.4	VIM, DES
30	infantile myofibromatosis	13.4	VIM, ACTC1, DES
31	pseudosarcomatous fibromatosis	13.4	VIM, ACTC1, DES
32	epithelioid leiomyosarcoma	13.4	VIM, ACTC1, DES
33	breast metaplastic carcinoma	13.4	VIM, S100A1, DES
34	benign metastasizing leiomyoma	13.4	VIM, ACTC1, DES
35	endometrial stromal sarcoma	13.4	VIM, ACTC1, DES
36	neural crest tumor	13.4	SDHAF2, SDHB, SDHD
37	carotid artery dissection	13.4	VIM, DES
38	desmoid tumor	13.4	S100A1, ACTC1, DES
39	colonic aganglionosis	13.4	S100A1, SYP
40	binswanger's disease	13.3	ACTC1, SYP
41	familial medullary thyroid carcinoma	13.3	SDHB, SDHD
42	chondroma	13.3	SDHB, SDHD, S100A1
43	vascular disease	13.3	GLMN, KRIT1
44	spiradenoma	13.3	S100A1, ACTC1
45	choledochal cyst	13.3	VIM, DES
46	granulosa cell tumor of the ovary	13.3	VIM, ACTC1, SYP
47	pulmonary blastoma	13.3	VIM, SYP
48	botryoid rhabdomyosarcoma	13.3	ACTC1, DES
49	myoma	13.3	ACTC1, DES
50	cystic teratoma	13.3	VIM, ACTC1, SYP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to glomus tumor:

²²

MGI Mouse Phenotypes related to glomus tumor:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal phenotype	MP:0002873	9.1	SYP, SMTN, SDHD, VHL
2	muscle phenotype	MP:0005369	8.2	ACTG1, ACTC1, NGFR, SMTN, S100A1, VHL
3	cardiovascular system phenotype	MP:0005385	7.9	VIM, DES, ACTC1, KRIT1, NGFR, SMTN
4	mortality/aging	MP:0010768	7.2	DES, ACTG1, KRIT1, NGFR, SMTN, GLMN

Articles related to glomus tumor:

(show all 19)

id	Title	Authors	Year	Affiliating Genes
1	Glomus tumors in neurofibromatosis type 1: genetic, f unctional, and clinical evidence of a novel association. (19738042)	Brems H.... Stewart D.R.	2009	CRTAC1
2	Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor. (19261679)	Goffrini P.... Mannelli M.	2009	SDHB
3	Glomus tumor of the stomach: a case report. (19145686)	Zissis D.... Vasilakaki T.	2008	VIM, DES, SYP
4	Glomus tumor presenting as a periurethral mass. (18820548)	Malowany J.I.... Colgan T.J.	2008	VIM, DES
5	Glomangiomyoma (glomus tumor) of the kidney. (16119994)	Siddiqui N.H.... Basil I.S.	2005	ACTC1
6	Malignant glomus tumor of the urinary bladder. (15974822)	Shim H.S.... Cho N.H.	2005	ACTC1
7	Recurrent epistaxis from an intranasal glomus tumor: the 22nd case report. (15217186)	Keelawat S.... Thanakit V.	2004	ACTC1
8	CD34-positive glomus tumor: clinicopathologic and immunohistochemical analysis of six cases with myxoid stromal changes. (12139637)	Mentzel T.... Kutzner H.	2002	VIM
9	Aspiration cytology of glomus tumor: a case report. (11726106)	Handa U.... Punia R.P.	2001	VIM
10	p53 and p16INK4A mutations during the progression of glomus tumor. (10079377)	GA1ran S.... Tali E.T.	1999	CDKN2B
11	Primary pulmonary glomus tumor: a clinicopathologic a nd immunohistochemical study of two cases. (9521471)	Koss M.N.... Moran C.A.	1998	DES
12	Vaginal glomus tumor presented as a painless cystic mass. (9600827)	Moldavsky M.... Turani H.	1998	S100B, VIM, DES
13	Cutaneous intraneural glomus tumor. (8600806)	Calonje E.... Fletcher C.D.	1995	S100A1
14	Glomus tumor. A histological, histochemical and immunohistochemical study of the various types. (8065987)	Liapi-Avgeri G.... Agnanti N.	1994	VIM, DES
15	Immunohistochemistry in the differential diagnosis of nodular hidradenoma and glomus tumor. (1380207)	Haupt H.M.... Berlin S.J.	1992	VIM, MUC1
16	Cutaneous glomus tumor. A comparative immunohistochemical study with pseudoangiomatous intradermal melanocytic nevi. (1848411)	Kaye V.M.... Dehner L.P.	1991	DES, S100A1
17	The immunophenotype of hemangiopericytomas and glomus tumors, with special reference to muscle protein expression: an immunohistochemical study and review of the literature. (1708501)	Porter P.L.... Gown A.M.	1991	VIM, DES, NGFR
18	Locally infiltrative glomus tumors and glomangiosarcomas. A clinical, ultrastructural, and immunohistochemical study. (2153045)	Gould E.W.... Monforte H.	1990	VIM
19	Intermediate filament proteins and actin isoforms as markers for soft-tissue tumor differentiation and origin. III. Hemangiopericytomas and glomus tumors. (2158236)	SchA1rch W.... Gabbiani G.	1990	VIM, DES, ACTG1

Genes related to glomus tumor according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	CRTAC1	cartilage acidic protein 1	11.1	Publications, Summaries
2	SDHAF2	succinate dehydrogenase complex assembly factor 2	11.1	Aliases & Descriptions
3	GLMN	glomulin, FKBP associated protein	11.0
4	S100A1	S100 calcium binding protein A1	11.0	Publications
5	DES	desmin	11.0	Publications
6	VIM	vimentin	11.0	Publications
7	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0
8	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
9	SYP	synaptophysin	11.0	Publications
10	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0	Publications
11	KRIT1	KRIT1, ankyrin repeat containing	11.0
12	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0
13	SMTN	smoothelin	11.0
14	ACTG1	actin, gamma 1	11.0	Publications
15	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
16	NGFR	nerve growth factor receptor	11.0	Publications
17	S100B	S100 calcium binding protein B	11.0	Publications
18	CD34	CD34 molecule	11.0
19	CALD1	caldesmon 1	11.0
20	MUC1	mucin 1, cell surface associated	11.0	Publications
21	F8	coagulation factor VIII, procoagulant component	11.0

Pathways related to glomus tumor according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeleton remodeling Neurofilaments10	9.7	VIM, ACTG1, DES
2	Hypertrophic cardiomyopathy (HCM)20	9.7	ACTC1, ACTG1, DES
3	Cytoskeleton remodeling_Neurofilaments41	9.6	DES, ACTG1, VIM
4	Cytoskeletal Signaling3	8.9	VIM, CALD1, ACTC1, ACTG1, DES
5	Neuroscience3	8.8	VHL, S100B, NGFR, SYP

Compounds related to glomus tumor according to GeneDecks:

(show top 50)    (show all 68)

id	Compound	Score	Top Affiliating Genes
1	toluidine32	10.2	VIM, S100A1, DES
2	2-methoxyethanol32	10.1	ACTC1, S100A1, VIM
3	UBIQUINONE-19 9	11.1	SDHB, SDHD
4	fumarate32 9 9	12.0	VHL, SDHB, SDHD
5	12-o-tetradecanoylphorbol 13-acetate32	9.8	NGFR, CD34
6	orcein32	9.8	DES, ACTC1, S100B, VIM
7	ganglioside32	9.7	DES, SYP, NGFR, VIM
8	dbc-amp32	9.4	SYP, NGFR, S100B, VIM
9	eosin32	9.3	VIM, MUC1, S100B
10	actomyosin32	9.3	ACTC1, KRIT1, CALD1, S100A1, VIM
11	nmda32 42	10.2	SYP, KRIT1, NGFR, SDHB, VIM
12	biotin32 9 18 9	12.2	DES, ACTC1, S100A1, MUC1, VIM
13	silver32	9.1	DES, SYP, F8, CD34, S100A1
14	choline32 9 18 9	12.1	SYP, NGFR, S100B, VIM
15	acetylcholine32 9 18 9	12.1	DES, SYP, NGFR, S100B, S100A1, VIM
16	catecholamine32	9.0	SYP, NGFR, S100B, SDHD, SDHB, VIM
17	methionine32	9.0	VIM, S100B, F8, KRIT1, DES
18	dihydrotestosterone32 9 18 9	12.0	DES, SMTN, MUC1, VIM
19	progestin32	9.0	VIM, MUC1, F8, DES
20	norepinephrine32 9 18 9	11.9	SDHB, S100B, F8, SYP, DES
21	retinoic acid32 42 18	10.9	SYP, NGFR, CD34, CDKN2B, S100B
22	gold32	8.7	DES, SYP, KRIT1, F8, MUC1
23	cysteine32	8.7	NGFR, S100B, S100A1, MUC1, SDHB
24	s 10032	8.7	DES, SYP, ACTC1, S100B, MUC1, VIM
25	actinomycin d32	8.5	VIM, VHL, MUC1, KRIT1, DES
26	mucicarmine32	8.5	ACTC1, SYP, DES, S100B, S100A1, MUC1
27	b 72332	8.5	DES, SYP, ACTC1, S100B, S100A1, MUC1
28	ethanol32 34 9 18 9	12.4	DES, SYP, NGFR, S100B, MUC1, SDHB
29	formaldehyde32 18	9.4	DES, SYP, ACTC1, KRIT1, S100B, MUC1
30	phospholipid32	8.4	SYP, F8, S100B, S100A1, MUC1
31	forskolin32 42 9 9	11.3	VIM, MUC1, S100B, NGFR, SYP
32	iron32 18	9.2	DES, ACTC1, F8, S100B, S100A1, SDHD
33	reticulin32	8.2	DES, VIM, MUC1, S100B, CD34, ACTC1
34	cyclic amp32 18	9.2	DES, SYP, KRIT1, NGFR, S100B, MUC1
35	estradiol32 9 18 9	11.1	DES, SYP, F8, MUC1, VIM
36	testosterone32 9 18 9	11.1	DES, SYP, ACTC1, KRIT1, S100B, MUC1
37	glycogen32 18	8.9	DES, SYP, ACTC1, S100B, S100A1, MUC1
38	creatinine32	7.9	DES, SYP, ACTC1, F8, S100B, MUC1
39	oxygen32 18	8.8	DES, ACTC1, NGFR, S100B, MUC1, SDHD
40	hematoxylin32	7.6	VIM, MUC1, S100A1, S100B, CD34, NGFR
41	paraffin32	7.6	DES, SYP, ACTC1, NGFR, CD34, S100B
42	glucose32	7.5	DES, ACTC1, NGFR, F8, S100B, MUC1
43	nitric oxide32 9 18 9	10.4	DES, SYP, KRIT1, NGFR, F8, S100B
44	dexamethasone32 42 34 9 9	11.3	SYP, ACTG1, ACTC1, KRIT1, NGFR, F8
45	progesterone32 42 9 18 9	11.0	DES, SYP, ACTC1, NGFR, F8, CD34
46	serine32	7.0	DES, SYP, KRIT1, NGFR, F8, CDKN2B
47	vegf32	6.7	DES, SYP, ACTC1, NGFR, F8, CD34
48	estrogen32	6.1	DES, SYP, ACTC1, KRIT1, NGFR, F8
49	tyrosine32	6.0	DES, SYP, ACTC1, KRIT1, NGFR, F8
50	calcium32 9 18 9	8.9	KRIT1, ACTC1, ACTG1, SYP, DES, NGFR

Cellular components related to glomus tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex II	GO:005749	9.7	SDHB, SDHD
2	cytoskeleton	GO:005856	8.7	VIM, CALD1, SMTN, KRIT1, ACTG1

Biological processes related to glomus tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	muscle filament sliding	GO:030049	9.8	VIM, ACTC1, DES
2	mitochondrial electron transport, succinate to ubiquinone	GO:006121	9.8	SDHAF2, SDHD

Molecular functions related to glomus tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ubiquinone binding	GO:048039	10.0	SDHB, SDHD
2	structural constituent of cytoskeleton	GO:005200	9.7	VIM, ACTG1, DES
3	S100 protein binding	GO:044548	9.5	S100A1, S100B
4	identical protein binding	GO:042802	8.9	SYP, ACTG1, S100B, S100A1, VIM
5	protein binding	GO:005515	5.7	VIM, DES, ACTG1, KRIT1, NGFR, GLMN