MCID: GLM008
MIFTS: 56

Glomus Tumor malady

Cancer diseases category

Summaries for Glomus Tumor

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards: Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and neurofibromatosis. An important gene associated with Glomus Tumor is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Glycolysis and gluconeogenesis (short map) and Pyruvate metabolism. The compounds dexamethasone and creatinine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related mouse phenotypes are integument and muscle.

Wikipedia:63 A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\" or glomangioma) is a... more...

Aliases & Classifications for Glomus Tumor

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

glomus tumor 8 44 48 60
glomus neoplasm 8
glomus tumour 8


External Ids:

Disease Ontology8 DOID:2431
NCIt39 C3060
MeSH34 D005918

Related Diseases for Glomus Tumor

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1glomangioma30.9GLMN
2neurofibromatosis30.6VHL, S100B, NGFR, KRAS, SDHD, SDHB
3hemangiopericytoma30.6ACTC1, CD34, MUC1, NGFR, DES, S100A1
4smooth muscle tumor30.3VIM, S100B, S100A1, DES, ACTC1
5paraganglioma30.3S100B, VHL, S100A1, SYP, SDHD, SDHB
6hemangioma30.2CD34, VHL, SDHB, SDHAF2, SDHD, ACTC1
7leiomyosarcoma30.2VIM, S100B, S100A1, DES, MUC1, CD34
8pleomorphic adenoma30.0VIM, ACTC1, MUC1, DES, S100A1, S100B
9adenoma30.0ACTC1, KRAS, MUC1, SYP, S100A1, VHL
10merkel cell carcinoma30.0SYP
11pancreatitis30.0KRAS
12chondroma30.0SDHB, SDHD
13glomuvenous malformation30.0GLMN, KRIT1
14carotid body tumor30.0SDHD, SDHB
15ischemia30.0SDHB, KRIT1, NGFR
16gastrointestinal stromal tumor30.0SDHB, ACTC1, CD34, DES, S100A1, S100B
17neurofibroma30.0VIM, S100B, S100A1, SYP, NGFR, MUC1
18squamous cell carcinoma30.0VIM, VHL, S100A1, SYP, NGFR, MUC1
19subungual glomus tumor10.7
20glomangiosarcoma10.5
21skin glomus tumor10.4
22glomangiomyoma10.3
23mediastinitis10.3
24vaginitis10.2
25glomus jugulare tumors10.2
26cerebritis10.1
27coats disease10.1
28pacinian tumor10.0
29dermatofibrosarcoma10.0
30osteoarthritis10.0
31gastric lymphoma10.0
32familial glomangioma10.0
33priapism10.0
34spiradenoma10.0
35nodular hidradenoma10.0
36gastric leiomyosarcoma10.0
37extraskeletal chondroma10.0
38cervicitis10.0
39complex regional pain syndrome10.0
40esophagitis10.0
41hidradenoma10.0
42mature teratoma10.0
43mature teratoma of the ovary10.0
44multiple sclerosis10.0
45neuropathy10.0
46peptic ulcer10.0
47periostitis10.0
48peripheral neuropathy10.0
49perivascular tumor10.0
50skin benign neoplasm10.0

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to glomus tumor

Clinical Features for Glomus Tumor

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Drugs & Therapeutics for Glomus Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glomus Tumor

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Anatomical Context for Glomus Tumor

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32MalaCards
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MalaCards organs/tissues related to Glomus Tumor:

32
Smooth muscle, Trachea, Kidney, Bone, Ovary, Breast, Tongue, Liver, Lung, Colon, Lymph node, Skin, Testes, Uterus, Endothelial, Spinal cord, Cervix

Animal Models for Glomus Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Glomus Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.3KRAS, CDKN2B, S100B, CD34
2MP:00053699.3SMTN, ACTG1, ACTC1, NGFR, VHL
3MP:00053769.0CD34, DES, NGFR, ACTC1, SDHD, GLMN
4MP:00020068.5CDKN2B, MUC1, VHL, KRAS, SDHD, CD34
5MP:00036318.3SDHD, ACTG1, KRIT1, GLMN, NGFR, SYP
6MP:00053858.0SDHD, VIM, VHL, S100A1, DES, NGFR
7MP:00028738.0MUC1, SYP, S100A1, S100B, VHL, ACTC1
8MP:00053847.8CDKN2B, VIM, CRTAC1, KRAS, VHL, SDHD
9MP:00107687.7SDHD, VIM, VHL, DES, NGFR, GLMN

Publications for Glomus Tumor

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Sources:
50PubMed
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Articles related to Glomus Tumor:

(show top 50)    (show all 621)
idTitleAuthorsYear
1
Pulmonary leiomyosarcoma mimicking glomus tumor at first biopsy and surgically treated with isolated left main bronchus resection: rare clinical documentation. (23636708)
2013
2
A voluminous glomus tumor of the leg. (22927536)
2013
3
Unusual motion detected on real-time sonography inside a glomus tumor in the thigh. (22729971)
2013
4
Percutaneous radiofrequency ablation of primary intraosseous spinal glomus tumor. (22072240)
2012
5
Malignant glomus tumor of the leg developed in the context of a superficial typical glomus tumor. (22228777)
2012
6
Glomus tumor of the stomach: a case treated by endoscopic submucosal dissection. (21482220)
2011
7
The anatomic location of digital glomus tumor recurrences. (20434277)
2010
8
Glomus tumor in the stomach. (19554363)
2010
9
Images in Rheumatology. Glomus tumor. (19509091)
2009
10
Irradiation of glomus jugulare tumors: a historical perspective. (18081478)
2007
11
Gamma knife radiosurgery for glomus jugulare tumors: volumetric analysis in 17 patients. (17143237)
2006
12
Glomus tumor of the trachea: value of multidetector computed tomographic virtual bronchoscopy. (14959919)
2004
13
Glomus tympanicum and glomus jugulare tumors. (11557448)
2001
14
Ultrastructural study of glomus tumor. (11853306)
2001
15
Congenital plaquelike glomus tumor in a child. (11438003)
2001
16
Periosteal glomus tumor of the femur: a case report. (11064992)
2000
17
Catecholamine secreting glomus tumor detected by iodine-123-MIBG scintigraphy. (8772645)
1996
18
Solid glomus tumor presenting as an axillary mass: report of a case with morphologic study, including cytologic characteristics. (8669195)
1996
19
Epithelioid glomus tumor. (7672784)
1995
20
Glomus tumor originating in the radial nerve: a case report. (1321179)
1992
21
Sonographic findings in glomus tumor of the stomach. (2538491)
1989
22
Glomus tumor: a benign gastric neoplasm. (2845299)
1988
23
Multifocal diffuse glomus tumor. A case report of glomangiomyoma and review of the literature. (2848911)
1988
24
Intraosseous glomus tumor in the ulna. A case report. (3036410)
1987
25
Vulvar pain and dyspareunia due to glomus tumor. (3003638)
1986
26
Glomus tumor of the stomach. (6322071)
1984
27
Histochemical evidence of adenosine triphosphatase activity in glomus tumor--report of a case. (6095231)
1984
28
A vascular lesion with smooth muscle differentiation presenting as a coin lesion in the lung: glomus tumor versus hemangiopericytoma. (6314802)
1983
29
Carcinoid apudoma arising in a glomus jugulare tumor: review of endocrine activity in glomus jugulare tumors. (6243385)
1980
30
Glomus tumor. (6257029)
1980
31
Glomus tumor of the coccygeal region. Case report. (6243305)
1980
32
Anaplastic astrocytoma following radiation for a glomus jugular tumor. (222421)
1979
33
Fine structure of a glomus tumor of the tongue and expression of C type virus in its tumor cells. (230158)
1979
34
The role of radiation therapy in the treatment of glomus jugulare tumors. (208745)
1978
35
The glomus tumor. (4343508)
1972
36
The ischemia test for glomus tumor: a new diagnostic test. (4315716)
1970
37
Painful forefoot from glomus tumor. (4318133)
1970
38
Ultrastructure of a hemangiopericytoma and a glomus tumor. (4303166)
1968
39
Cryosurgical management of glomus jugulare tumors. (4290656)
1967
40
Intraosseous glomus tumor. A case report. (4292584)
1967
41
METASTASES OF GLOMUS JUGULARE TUMORS. (14310182)
1965
42
Glomus tumor of the stomach. (14002266)
1962
43
Glomus tumor of the stomach. (13549777)
1958
44
Glomus tumor of the vagina; report of a case. (13419242)
1957
45
Hemangiopericytoma (glomus tumor) of the thigh: case report. (13313990)
1956
46
Glomus tumor; a report of two cases. (13065591)
1953
47
Surgical problems involved in the removal of glomus-jugulare tumors. (13015599)
1951
48
Carotid body-like tumors of the temporal bone; with particular reference to glomus-jugulare tumors. (14857626)
1951
49
Subungual glomus tumor; report of a case. (18890423)
1948
50
Neuromyoarterial Glomus Tumor in the Eyelid. (16693240)
1940

Genetic Variations for Glomus Tumor

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Expression for genes affiliated with Glomus Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glomus Tumor

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Pathways for genes affiliated with Glomus Tumor

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Glomus Tumor

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Glomus Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1113.4S100B, KRIT1
2creatinine4410.3ACTC1, SDHB, SYP
3UBIQUINONE-11110.2SDHB, SDHD
4fumarate44 1111.1SDHB, SDHD, VHL
5glycogen44 2411.1SDHB, ACTC1, SYP, VHL
6eosin4410.1S100B, VIM, MUC1
7forskolin44 49 1112.1NGFR, VIM
8orcein4410.1VIM, DES, ACTC1, S100B
92-methoxyethanol4410.1VIM, S100A1, ACTC1
10toluidine4410.1VIM, DES, S100A1
11acetylcholine44 49 28 11 2414.0S100A1, SYP, NGFR
12ganglioside4410.0DES, SYP, NGFR, VIM
13glutamate4410.0NGFR, KRIT1
14dbc-amp449.9S100B, VIM, NGFR, SYP
15actomyosin449.9VIM, KRIT1, ACTC1, S100A1
16gold449.9MUC1, SYP, KRIT1, DES
17glucose449.8MUC1, NGFR, SDHB, ACTC1
18choline44 11 2411.8NGFR, VIM, S100B, SYP
19imatinib44 49 1111.7S100B, ACTC1, KRAS, DES
20nmda44 2810.7SYP, NGFR, KRIT1, SDHB, VIM
21biotin44 11 2411.7VIM, ACTC1, MUC1, DES, S100A1
22dihydrotestosterone44 28 11 2412.7VIM, MUC1, SMTN, DES
23s 100449.7VIM, S100B, SYP, MUC1, ACTC1, DES
24silver449.6S100A1, DES, SYP, CD34
25actinomycin d449.6VHL, DES, KRIT1, VIM, MUC1
26catecholamine449.6SDHD, NGFR, SYP, S100B, VIM, SDHB
27ethanol44 49 11 2412.5S100B, DES, SYP, NGFR, MUC1, SDHB
28h2o2449.5DES, KRAS, KRIT1, VIM, SDHB, SYP
2912-o-tetradecanoylphorbol 13-acetate449.4DES, MUC1, CD34, NGFR, VIM
30formaldehyde44 2410.4MUC1, KRIT1, VIM, S100B, DES, ACTC1
31mucicarmine449.3VIM, S100B, S100A1, DES, SYP, ACTC1
32b 723449.3MUC1, ACTC1, SYP, DES, S100A1, S100B
33cyclic amp44 2410.3VIM, KRIT1, MUC1, NGFR, SYP, DES
34reticulin449.2VIM, ACTC1, CD34, MUC1, SYP, DES
35testosterone44 59 11 2412.2SDHB, ACTC1, KRIT1, S100B, MUC1, SYP
36iron44 2410.1VIM, SDHB, VHL, SDHD, S100B, S100A1
37threonine449.0CDKN2B, MUC1, DES, S100B, NGFR, KRIT1
38nitric oxide44 11 2410.9VHL, SYP, KRIT1, MUC1, NGFR, DES
39oxygen44 249.8MUC1, SDHB, S100B, DES, KRAS, NGFR
40thymidine44 249.8CD34, MUC1, NGFR, DES, S100B
41cysteine448.7S100A1, MUC1, S100B, VIM, NGFR, KRIT1
42lipid448.7MUC1, KRAS, S100B, VIM, SYP, NGFR
43hematoxylin448.6DES, MUC1, SYP, VIM, S100B, S100A1
44progesterone44 59 28 11 2412.6S100B, NGFR, S100A1, DES, SYP, VIM
45serine448.5S100B, SYP, CDKN2B, VIM, NGFR, MUC1
46paraffin448.3KRAS, CD34, MUC1, NGFR, SYP, DES
47vegf448.2ACTC1, MUC1, NGFR, SYP, CD34, KRAS
48calcium44 49 11 2411.2SDHB, SYP, NGFR, MUC1, ACTG1, KRIT1
49retinoic acid44 249.0S100B, DES, S100A1, SYP, NGFR, MUC1
50tyrosine447.5MUC1, CDKN2B, CD34, KRAS, KRIT1, ACTC1

GO Terms for genes affiliated with Glomus Tumor

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16Gene Ontology
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Cellular components related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.8ACTG1, ACTC1, VIM
2mitochondrial respiratory chain complex IIGO:0057499.8SDHB, SDHD

Biological processes related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.0ACTC1, DES, VIM

Molecular functions related to Glomus Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:04803910.0SDHB, SDHD
2structural constituent of cytoskeletonGO:0052009.8VIM, DES, ACTG1
3S100 protein bindingGO:0445489.5S100A1, S100B
4identical protein bindingGO:0428029.0S100A1, DES, VIM, SYP, ACTG1, S100B
5protein bindingGO:0055157.1DES, S100B, VHL, VIM, NGFR, MUC1

Products for genes affiliated with Glomus Tumor

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Sources for Glomus Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet