MCID: GLS007
MIFTS: 47

Glossitis malady

Gastrointestinal diseases category

Summaries for Glossitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

MalaCards: Glossitis, also known as glossitis nos, is related to median rhomboid glossitis and malaria. An important gene associated with Glossitis is KRT6B (keratin 6B), and among its related pathways are Legionellosis and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gm-csf and anisomycin have been mentioned in the context of this disorder. Affiliated tissues include tongue, endothelial and monocytes, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Glossitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

glossitis 8 10 60
glossitis nos 8


External Ids:

Disease Ontology8 DOID:1456
MeSH34 D005928
ICD9CM27 529.0
ICD1025 K14.0

Related Diseases for Glossitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Glossitis:



Diseases related to glossitis

Clinical Features for Glossitis

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Drugs & Therapeutics for Glossitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glossitis

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Anatomical Context for Glossitis

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32MalaCards
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MalaCards organs/tissues related to Glossitis:

32
Tongue, Endothelial, Monocytes, Lung, Liver, Colon, Heart, Spinal cord, Bone, Bone marrow

Animal Models for Glossitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Glossitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7KRT6B, KRT6A, IL6, TNF, GCG

Publications for Glossitis

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50PubMed
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Articles related to Glossitis:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Clinical pathologic conference case 5: Unusual severe glossitis. (23738346)
2013
2
Glossitis secondary to vitamin B12 deficiency anemia. (23359038)
2013
3
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. (22762365)
2012
4
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. (22188475)
2012
5
The development and inflammatory features of radiotherapy-induced glossitis in rats. (21196832)
2011
6
The correlation between the severity of radiotherapy-induced glossitis and endothelial cell injury in local tissues in a rat model. (21196860)
2011
7
Taste evaluation in adolescents and pediatric patients with benign migratory glossitis. (21802154)
2011
8
Median rhomboid glossitis. (21446620)
2011
9
Predisposition of allergy in patients with benign migratory glossitis. (20674406)
2010
10
Partial atrophic tongue other than median rhomboid glossitis. (17441970)
2007
11
Pachyonychia congenita associated with median rhomboid glossitis. (17511954)
2007
12
Atrophic glossitis from vitamin B12 deficiency: a case misdiagnosed as burning mouth disorder. (17209796)
2006
13
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. (15316160)
2004
14
Immunohistochemical and ultrastructural identification of Fusobacterium necrophorum subsp. necrophorum in bovine fatal necrotizing glossitis. (12130839)
2002
15
Ulcerative glossitis in a dog with leishmaniasis. (12356241)
2002
16
Dermatitis, glossitis, stomatitis, cheilitis, anemia and weight loss: a classic presentation of pancreatic glucagonoma. (11941895)
2002
17
Helicobacter pylori colonization of tongue mucosa--increased incidence in atrophic glossitis and burning mouth syndrome (BMS). (11555160)
2001
18
Herpetic geometric glossitis: a distinctive pattern of lingual herpes simplex virus infection. (7502116)
1995
19
Quantitative evaluation of Langerhans cells in median rhomboid glossitis. (1593492)
1992
20
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). (1841980)
1991
21
Case #5. Benign migratory glossitis. (1887082)
1991
22
Severe facial oedema and glossitis associated with mianserin. (2571803)
1989
23
Median rhomboid glossitis. A follow-up study of 16 patients. (3459824)
1986
24
Glossitis and dysgeusia. (6517995)
1984
25
Glossitis, folic acid and pernicious anemia. (6635752)
1983
26
Median rhomboid glossitis caused by Candida? (282562)
1979
27
Acute glossitis due to Hemophilus influenzae type b. (308534)
1978
28
Ulcerative glossitis. A facet of feline panleukopenia. (1219114)
1975
29
Glossitis of military working dogs in Vietnam: experimental production of tongue lesions. (4214371)
1974
30
Idiopathic gingivostomatitis. Cheilitis, glossitis, gingivitis syndrome; atypical gingivostomatitis, plasma-cell gingivitis, plasmacytosis of gingiva. (5285187)
1971
31
Moeller's glossitis. (13930640)
1962
32
Capillary lymphangioma of the tongue complicated by glossitis. (13753050)
1961
33
Carcinoma arising in glossitis rhombica mediana. (13500310)
1958
34
Glossitis. (13417962)
1957
35
GINGIVITIS and glossitis of undertermined origin. (14371218)
1955
36
The cytology of the bone marrow in pernicious anaemia with normal haemoglobin level; glossitis and subacute combined degeneration of the spinal cord due to deficiency of the anti-pernicious-anaemia principle. (13137955)
1954
37
Some aspects of the tongue in pellagrous glossitis. (13061600)
1953
38
Syndrome of anemia, dysphagia and glossitis (Plummer Vinson syndrome). (13111401)
1953
39
Deficiency glossitis. (14827541)
1951
40
Glossitis as indicator of nutritional deficiency in the aged. (14786914)
1950
41
A case for diagnosis (syphilitic glossitis?). (20287978)
1947
42
Moeller's glossitis; a case with remission during pregnancy. (20292634)
1947
43
Glossitis rhomboidea mediana. (20240701)
1947
44
A case for diagnosis (Moeller's glossitis? glossitis due to vitamin B deficiency; glossitis due to phenobarbital?). (21000221)
1946
45
Relief of pellagrous glossitis with synthetic folic acid. (21001461)
1946
46
A case of malaria with severe glossitis. (20997031)
1946
47
Glossitis Rhombica Mediana. (19990743)
1936
48
A CASE OF LATE SYPHILITIC GLOSSITIS TREATED BY SALVARSAN (EHRLICH-HATA). (20766080)
1912
49
Glossitis in a Girl aged 3A1. (20897256)
1908
50
Case of Acute Glossitis. (20794079)
1846

Genetic Variations for Glossitis

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Expression for genes affiliated with Glossitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for genes affiliated with Glossitis

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 53Reactome
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Pathways related to Glossitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL1B
29.8IL6, IL1B
39.8IL1B, TNF
49.8IL1B, TNF
59.8IL6, TNF
69.6LMBRD1, GIF
79.6LMBRD1, GIF
89.4IL6, IL1B, TNF
99.4IL6, IL1B, TNF
109.4IL6, IL1B, TNF
119.4IL6, IL1B, TNF
12
Development PDGF signaling via STATs and NF-kB
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9.4IL6, IL1B, TNF
13
Hide members
9.4IL6, IL1B, TNF
149.4IL6, IL1B, TNF
15
Hide members
9.4IL6, IL1B, TNF
16
Immune response Bacterial infections in normal airways
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9.4IL6, IL1B, TNF
17
Hide members
9.4IL6, IL1B, TNF
189.4TNF, IL1B, IL6
19
Hide members
9.4TNF, IL1B, IL6
209.4TNF, IL1B, IL6
219.4TNF, IL1B, IL6
229.4TNF, IL1B, IL6
23
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.4TNF, IL1B, IL6
249.4TNF, IL1B, IL6
259.4TNF, IL1B, IL6
269.4TNF, IL1B, IL6
279.4TNF, IL1B, IL6
28
Hide members
9.4TNF, IL1B, IL6
299.4TNF, IL1B, IL6

Compounds for genes affiliated with Glossitis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Glossitis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.5TNF
2anisomycin44 1111.4IL6
3muramyl tripeptide phosphatidylethanolamine4410.2IL6, IL1B
4turpentine4410.2IL6, IL1B
5tocilizumab44 1111.1TNF, IL6
6abatacept44 1111.1IL6, TNF
7cdp5714410.1IL6, TNF
8bucillamine4410.0IL1B, IL6
9n,n-dimethylsphingosine44 5911.0IL1B, TNF
10cicaprost44 2810.9TNF, IL1B
11anakinra44 1110.9TNF, IL1B, IL6
12vesnarinone449.9IL1B, TNF, IL6
13taurine chloramine449.9TNF, IL1B, IL6
14mip 1alpha449.9TNF, IL6, IL1B
15il-12449.9TNF, IL1B, IL6
16tpck449.9IL1B, TNF, IL6
17polymyxin b449.9TNF, IL1B, IL6
18groalpha449.9IL1B, TNF, IL6
19leflunomide49 44 1111.9TNF, IL1B, IL6
20triptolide449.9IL6, TNF, IL1B
21ciglitazone44 2810.9IL1B, TNF, IL6
22lipoteichoic acid449.9IL1B, IL6, TNF
23polyinosinic-polycytidylic acid449.8IL1B, IL6, TNF
24etanercept44 49 1111.8TNF, IL1B, IL6
25poly(i-c)449.8IL6, IL1B, TNF
26il 10449.8IL1B, TNF, IL6
27gabexate mesilate449.8TNF, IL6
28infliximab44 49 1111.8IL1B, TNF, IL6
29peptidoglycan44 2810.8IL1B, TNF, IL6
30hbd2449.8IL6, IL1B
31ivig449.8IL6, TNF, IL1B
32ccl344 2810.8IL1B, TNF, IL6
3315-deoxy-delta-12,14-prostaglandin j2449.8TNF, IL1B, IL6
34pdtc449.7IL1B, IL6, TNF
35thalidomide44 49 59 1112.7TNF, IL1B, IL6
36leukotriene b444 59 2411.7IL6, IL1B, TNF
37sp 60012544 5910.6IL1B, TNF, IL6
38melphalan44 1110.6IL6, TTR, TNF
39pioglitazone44 49 28 1112.6IL6, TNF, GCG
40hydrocortisone44 2 59 1112.5IL6, TNF, IL1B
41toxin-1449.5TNF, IL1B
42troglitazone44 28 59 1112.4IL6, IL1B, TNF
43neopterin449.4TNF, IL1B, IL6, TTR
44indomethacin44 59 28 1112.3IL1B, TNF, GCG, IL6
45sb 20358044 5910.3GCG, TNF, IL1B, IL6
46histamine44 28 2411.2GCG, TNF, IL1B, IL6
47pd 98,059449.2TNF, GCG, IL6, IL1B
48ly294002449.2GCG, TNF, IL1B, IL6
49genistein44 28 59 2 11 2413.8GCG, TNF, TTR, IL6, IL1B
50lactate448.6GCG, IL6, TTR, TNF

GO Terms for genes affiliated with Glossitis

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16Gene Ontology
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Cellular components related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0TNF, GIF, IL1B, IL6, TTR, GCG
2extracellular spaceGO:0056157.7TTR, IL6, IL1B, GIF, TNF, GCG

Biological processes related to Glossitis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1TNF, IL1B
2sequestering of triglycerideGO:03073010.1TNF, IL1B
3positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
4positive regulation of fever generationGO:03162210.1TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:04508010.1IL1B, TNF
6ectoderm developmentGO:00739810.1KRT6B, KRT6A
7epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1TNF, IL6
8negative regulation of lipid storageGO:01088810.1TNF, IL6
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.1IL1B, TNF
10positive regulation of membrane protein ectodomain proteolysisGO:05104410.0TNF, IL1B
11negative regulation of lipid catabolic processGO:05099510.0IL1B, TNF
12positive regulation of chemokine productionGO:03272210.0IL6, TNF
13positive regulation of NF-kappaB import into nucleusGO:0423469.9TNF, IL1B
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.8IL6, IL1B, TNF
16positive regulation of interleukin-6 productionGO:0327559.8IL6, IL1B, TNF
17positive regulation of mitosisGO:0458409.8TNF, IL1B
18protein kinase B signaling cascadeGO:0434919.8IL1B, TNF
19positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8IL6, IL1B, TNF
20cobalamin metabolic processGO:0092359.7LMBRD1, GIF
21positive regulation of NF-kappaB transcription factor activityGO:0510929.7IL6, IL1B, TNF
22lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, IL1B
23positive regulation of peptidyl-serine phosphorylationGO:0331389.6IL6, TNF, GCG
24regulation of insulin secretionGO:0507969.6IL1B, TNF, GCG
25positive regulation of ERK1 and ERK2 cascadeGO:0703749.5GCG, TNF, IL6
26cellular response to organic cyclic compoundGO:0714079.5IL1B, TNF

Molecular functions related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL6, IL1B, TNF
2cobalamin bindingGO:0314199.3LMBRD1, GIF

Products for genes affiliated with Glossitis

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Sources for Glossitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet