MCID: GLS007
MIFTS: 47

Glossitis malady

Gastrointestinal diseases category

Summaries for Glossitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

MalaCards: Glossitis, also known as glossitis nos, is related to median rhomboid glossitis and malaria. An important gene associated with Glossitis is KRT6B (keratin 6B), and among its related pathways are Legionellosis and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gm-csf and anisomycin have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and endothelial, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Glossitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

glossitis 8 10 60
glossitis nos 8


External Ids:

Disease Ontology8 DOID:1456
MeSH34 D005928
ICD9CM27 529.0
ICD1025 K14.0

Related Diseases for Glossitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Glossitis:



Diseases related to glossitis

Clinical Features for Glossitis

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Drugs & Therapeutics for Glossitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glossitis

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Anatomical Context for Glossitis

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32MalaCards
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MalaCards organs/tissues related to Glossitis:

32
Tongue, Bone, Endothelial, Monocytes, Heart, Bone marrow, Lung, Spinal cord, Liver, Colon

Animal Models for Glossitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Glossitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7KRT6B, KRT6A, IL6, TNF, GCG

Publications for Glossitis

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Sources:
50PubMed
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Articles related to Glossitis:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Benign migratory glossitis with fissured tongue. (22918106)
2012
2
Median rhomboid glossitis: a clinical and microbiological study. (21912494)
2011
3
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. (20339702)
2010
4
The prevalence and risk factors associated with benign migratory glossitis lesions in 7619 Turkish dental outpatients. (19138635)
2009
5
Glossitis with linear lesions: an early sign of vitamin B12 deficiency. (19231648)
2009
6
Primary tuberculous glossitis in an immunocompetent patient. (17664540)
2007
7
Investigation of functional gene polymorphisms: IL-1B, IL-6 and TNFA in benign migratory glossitis in Brazilian individuals. (17850436)
2007
8
Atrophic glossitis leading to the diagnosis of celiac disease. (17568041)
2007
9
Clinical challenge. Tongue--multifocal pyogranulomatous glossitis. (18229872)
2007
10
Persisting afebrile swelling of the lips and tongue: an unusual case of granulomatous glossitis. (16443435)
2006
11
Fungiform papillary glossitis: a 'new' diagnosis or a 'misdiagnosis'? (16911304)
2006
12
Papular-like glossitis in a dog with leishmaniosis. (15747661)
2005
13
Rhomboid glossitis in atypical location: case report and differential diagnosis. (15735544)
2005
14
Painful geographic tongue (benign migratory glossitis) in a child. (15482313)
2004
15
A case of median rhomboid glossitis. (12773811)
2003
16
Glossitis and other tongue disorders. (12622275)
2003
17
Ulcerative glossitis in a dog with leishmaniasis. (12201262)
2002
18
Benign migratory glossitis or geographic tongue: an enigmatic oral lesion. (12517366)
2002
19
Oral pathology quiz #2. Median rhomboid glossitis. (11808366)
2001
20
Chronic herpes simplex virus type I glossitis in an immunocompromised man. (10233235)
1999
21
Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism. (9674310)
1998
22
Cause of median rhomboid glossitis. (8705579)
1996
23
Granulomatous glossitis as an unusual manifestation of Melkersson-Rosenthal syndrome. (7796618)
1995
24
Herpetic geometric glossitis. (8018159)
1994
25
Brief report: herpetic geometric glossitis. (8247038)
1993
26
Acute glossitis and bacteremia caused by Streptococcus pneumoniae: case report and review. (2035482)
1991
27
Candida albicans in median rhomboid glossitis. A postmortem study. (3088163)
1986
28
Glossitis associated with mianserin. (6141376)
1984
29
Hypertrophic glossitis in secondary syphilis. (7425658)
1980
30
Atypical benign migratory glossitis. Report of a case with histologic and electron microscopic evaluations. (1069222)
1976
31
Benign migratory glossitis. (1054669)
1975
32
Surgery required in treatment of glossitis. (1041101)
1975
33
Contact stomatitis, glossitis, and cheilitis. (4417554)
1974
34
Benign migratory glossitis associated with lichen planus. (4524269)
1974
35
Atrophic luetic glossitis. Report of a case. (5270921)
1970
36
Isolation of a feline picornavirus from cheetahs with conjunctivitis and glossitis. (5533341)
1970
37
Median rhomboid glossitis. Case report. (5353692)
1969
38
GLOSSITIS TRAUMATICA. WAYS IN WHICH NORMALLY SHAPED, HEALTHY TEETH MAY INJURE THE TONGUE. (14307401)
1965
39
Glossitis with complete loss of taste sensation during dindevan treatment. Report of a case. (14444264)
1960
40
Glossitis and the pre-anaemic stage of pernicious anaemia; diagnosis by simple methods. (13439981)
1957
41
Reiter's syndrome with biopsy from recurrent glossitis. (13354471)
1956
42
A case of acute BAL toxicity during treatment of gold glossitis. (18136352)
1949
43
Observations on the effect of an animal protein factor concentrate on persons with the macrocytic anemia of pernicious anemia, of nutritional macrocytic anemia and of sprue, and on persons with nutritional glossitis. (18150159)
1949
44
Glossitis rhombica mediana: report of a case. (20264610)
1947
45
Glossitis and stomatitis due to penicillin lozenges and troches. (21016496)
1946
46
Glossitis rhombica mediana? (21064482)
1946
47
GLOSSITIS, oral fissures, and dysphagia as signs of iron deficiency. (20275438)
1946
48
GLOSSITIS RHOMBICA MEDIANA. (17857116)
1938
49
Glossitis Migrans. (19984958)
1926
50
Glossitis Migrans; a large unknown Coccus present. (19985451)
1926

Genetic Variations for Glossitis

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Expression for genes affiliated with Glossitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for genes affiliated with Glossitis

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 53Reactome
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Pathways related to Glossitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL1B
29.8IL6, IL1B
39.8IL1B, TNF
49.8IL1B, TNF
59.8IL6, TNF
69.6LMBRD1, GIF
79.6LMBRD1, GIF
89.4IL6, IL1B, TNF
99.4IL6, IL1B, TNF
109.4IL6, IL1B, TNF
119.4IL6, IL1B, TNF
12
Development PDGF signaling via STATs and NF-kB
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9.4IL6, IL1B, TNF
13
Hide members
9.4IL6, IL1B, TNF
149.4IL6, IL1B, TNF
15
Hide members
9.4IL6, IL1B, TNF
16
Immune response Bacterial infections in normal airways
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9.4IL6, IL1B, TNF
17
Hide members
9.4IL6, IL1B, TNF
189.4TNF, IL1B, IL6
19
Hide members
9.4TNF, IL1B, IL6
209.4TNF, IL1B, IL6
219.4TNF, IL1B, IL6
229.4TNF, IL1B, IL6
23
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.4TNF, IL1B, IL6
249.4TNF, IL1B, IL6
259.4TNF, IL1B, IL6
269.4TNF, IL1B, IL6
279.4TNF, IL1B, IL6
28
Hide members
9.4TNF, IL1B, IL6
299.4TNF, IL1B, IL6

Compounds for genes affiliated with Glossitis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Glossitis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.5TNF
2anisomycin44 1111.4IL6
3muramyl tripeptide phosphatidylethanolamine4410.2IL6, IL1B
4turpentine4410.2IL1B, IL6
5tocilizumab44 1111.1TNF, IL6
6abatacept44 1111.1TNF, IL6
7cdp5714410.1IL6, TNF
8bucillamine4410.0IL6, IL1B
9n,n-dimethylsphingosine44 5911.0IL1B, TNF
10cicaprost44 2810.9TNF, IL1B
11anakinra44 1110.9TNF, IL1B, IL6
12taurine chloramine449.9TNF, IL1B, IL6
13vesnarinone449.9TNF, IL1B, IL6
14mip 1alpha449.9IL6, IL1B, TNF
15il-12449.9TNF, IL1B, IL6
16tpck449.9IL6, IL1B, TNF
17polymyxin b449.9IL6, IL1B, TNF
18groalpha449.9TNF, IL1B, IL6
19leflunomide49 44 1111.9TNF, IL1B, IL6
20triptolide449.9IL6, IL1B, TNF
21ciglitazone44 2810.9TNF, IL1B, IL6
22lipoteichoic acid449.9IL6, IL1B, TNF
23polyinosinic-polycytidylic acid449.8TNF, IL1B, IL6
24etanercept44 49 1111.8TNF, IL1B, IL6
25poly(i-c)449.8IL6, IL1B, TNF
26il 10449.8IL6, IL1B, TNF
27gabexate mesilate449.8IL6, TNF
28infliximab44 49 1111.8IL6, IL1B, TNF
29peptidoglycan44 2810.8IL6, IL1B, TNF
30ivig449.8TNF, IL1B, IL6
31ccl344 2810.8IL6, IL1B, TNF
32toxin-1449.8IL1B, TNF
3315-deoxy-delta-12,14-prostaglandin j2449.8TNF, IL1B, IL6
34pdtc449.7IL6, IL1B, TNF
35thalidomide44 49 59 1112.7IL6, IL1B, TNF
36leukotriene b444 59 2411.7TNF, IL1B, IL6
37sp 60012544 5910.6IL6, IL1B, TNF
38melphalan44 1110.6TNF, IL6, TTR
39pioglitazone44 49 28 1112.6IL6, TNF, GCG
40hydrocortisone44 2 59 1112.5IL6, IL1B, TNF
41hbd2449.5IL6, IL1B
42troglitazone44 28 59 1112.4TNF, IL1B, IL6
43neopterin449.4TTR, IL6, IL1B, TNF
44indomethacin44 59 28 1112.3IL6, IL1B, TNF, GCG
45sb 20358044 5910.3IL6, IL1B, TNF, GCG
46histamine44 28 2411.2GCG, TNF, IL1B, IL6
47pd 98,059449.2GCG, TNF, IL1B, IL6
48ly294002449.2IL6, IL1B, TNF, GCG
49genistein44 28 59 2 11 2413.8GCG, TNF, IL1B, IL6, TTR
50lactate448.6TTR, IL6, TNF, GCG

GO Terms for genes affiliated with Glossitis

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16Gene Ontology
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Cellular components related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0TNF, GIF, IL1B, IL6, TTR, GCG
2extracellular spaceGO:0056157.7TTR, IL6, IL1B, GIF, TNF, GCG

Biological processes related to Glossitis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1TNF, IL1B
2sequestering of triglycerideGO:03073010.1TNF, IL1B
3positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
4positive regulation of fever generationGO:03162210.1TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:04508010.1IL1B, TNF
6ectoderm developmentGO:00739810.1KRT6B, KRT6A
7epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1TNF, IL6
8negative regulation of lipid storageGO:01088810.1TNF, IL6
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.1IL1B, TNF
10positive regulation of membrane protein ectodomain proteolysisGO:05104410.0TNF, IL1B
11negative regulation of lipid catabolic processGO:05099510.0IL1B, TNF
12positive regulation of chemokine productionGO:03272210.0IL6, TNF
13positive regulation of NF-kappaB import into nucleusGO:0423469.9TNF, IL1B
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.8IL6, IL1B, TNF
16positive regulation of interleukin-6 productionGO:0327559.8IL6, IL1B, TNF
17positive regulation of mitosisGO:0458409.8TNF, IL1B
18protein kinase B signaling cascadeGO:0434919.8IL1B, TNF
19positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8IL6, IL1B, TNF
20cobalamin metabolic processGO:0092359.7LMBRD1, GIF
21positive regulation of NF-kappaB transcription factor activityGO:0510929.7IL6, IL1B, TNF
22lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, IL1B
23positive regulation of peptidyl-serine phosphorylationGO:0331389.6IL6, TNF, GCG
24regulation of insulin secretionGO:0507969.6IL1B, TNF, GCG
25positive regulation of ERK1 and ERK2 cascadeGO:0703749.5GCG, TNF, IL6
26cellular response to organic cyclic compoundGO:0714079.5IL1B, TNF

Molecular functions related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL6, IL1B, TNF
2cobalamin bindingGO:0314199.3LMBRD1, GIF

Products for genes affiliated with Glossitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glossitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet