MCID: GLS007
MIFTS: 40

Glossitis malady

Gastrointestinal category

Summaries for Glossitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

MalaCards: Glossitis, also known as glossitis nos, is related to median rhomboid glossitis and pachyonychia congenita. An important gene associated with Glossitis is KRT6B (keratin 6B), and among its related pathways are Legionellosis and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gm-csf and anisomycin have been mentioned in the context of this disorder. Related mouse phenotype digestive/alimentary.

Aliases & Classifications for Glossitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

glossitis 8 10 61
glossitis nos 8


External Ids:

Disease Ontology8 DOID:1456
MeSH35 D005928
ICD9CM27 529.0
ICD1025 K14.0

Related Diseases for Glossitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Glossitis:



Diseases related to glossitis

Clinical Features for Glossitis

Drugs & Therapeutics for Glossitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glossitis

Anatomical Context for Glossitis

Animal Models for Glossitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Glossitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7KRT6B, KRT6A, IL6, TNF, GCG

Publications for Glossitis

Sources:
51PubMed
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Articles related to Glossitis:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). (24236384)
2013
2
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. (24060545)
2013
3
A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine. (22918478)
2012
4
Median rhomboid glossitis: a clinical and microbiological study. (21912494)
2011
5
Oral pathology. Benign migratory glossitis. (20806635)
2010
6
Successful treatment with cyclosporin administration for persistent benign migratory glossitis. (17408445)
2007
7
Median rhomboid glossitis. (17990677)
2007
8
Images in clinical medicine. Herpetic glossitis. (17881747)
2007
9
Persisting afebrile swelling of the lips and tongue: an unusual case of granulomatous glossitis. (16443435)
2006
10
Granulomatous glossitis: a case report. (15508754)
2004
11
Kaposi's sarcoma of the tongue associated with median rhomboid glossitis in a non-AIDS patient. A case report. (15274372)
2004
12
Taste disorder involving Hunter's glossitis following total gastrectomy. (12132615)
2002
13
Folate and vitamin B12 levels in patients with oral lichen planus, stomatitis or glossitis. (11944731)
2001
14
Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism. (9674310)
1998
15
Glossitis, stomatitis, and black tongue with lansoprazole plus clarithromycin and other antibiotics. (9416400)
1997
16
Median rhomboid glossitis and a "kissing" lesion of the palate. (8936507)
1996
17
Median rhomboid glossitis. (8899768)
1996
18
Median rhomboid glossitis. An oral manifestation in patients infected with HIV. (8078660)
1994
19
Polycythaemia rubra vera presenting with severe glossitis. (7831188)
1994
20
Median rhomboid glossitis: review of a puzzling entity. (2097050)
1990
21
Median rhomboid glossitis in an infant. Report of a case. (3861810)
1985
22
Tobacco smoking and denture wearing as local aetiological factors in median rhomboid glossitis. (6438002)
1984
23
Glossitis associated with mianserin. (6141376)
1984
24
Benign migratory glossitis--a cause for worry? (7334963)
1981
25
Prevalence of glossitis and angular stomatitis in urban women from low income group. (7309196)
1981
26
Median rhomboid glossitis: not a misnomer. Review of the literature and histologic study of twenty-eight cases. (366496)
1978
27
Histopathology and electron and immunofluorescence microscopy of gingivitis granulomatosa associated with glossitis and cheilitis in a case of Anderson-Fabry disease. (101930)
1978
28
Pasteurella multocida from canine and feline teeth, with a case report of glossitis calcinosa in a dog caused by P. multocida. (693275)
1978
29
Glossitis of military working dogs in south Vietnam; histopathologic observations. (1137213)
1975
30
Median rhomboid glossitis. Candidiasis and not a developmental anomaly. (1201190)
1975
31
Hereditary component in the etiology of benign migratory glossitis. (5016506)
1972
32
Median rhomboid glossitis: a developmental anomaly? (5275506)
1971
33
Median rhomboid glossitis. Case report. (5353692)
1969
34
Incidence of geographic tongue and median rhomboid glossitis in 3,319 Negro college students. (5245682)
1968
35
Diseases in cattle in contact with swine under feedlot conditions. II. Case studies on a glossitis-respiratory complex. (5257334)
1967
36
SUPPURATIVE PARENCHYMATOUS GLOSSITIS. (14261137)
1965
37
MAY-HEGGLIN ANOMALY ASSOCIATED WITH GLOSSITIS, PHARYNGITIS AND MUSCULAR HYPOTONIA. (14208037)
1964
38
Glossitis in feedlot cattle. (13782593)
1961
39
RECURRENT glossitis; constantly recurring histamine-refractory achlorhydria. (14371210)
1955
40
Glossitis and epithelial atrophy in old age; its relation to iron and vitamin B deficiency. (12999388)
1952
41
A note on tryptophane and pellagrous glossitis. (14861512)
1951
42
Tentative methods for the relief of discoloration of the tongue and of glossitis associated with the use of aureomycin. (14882796)
1951
43
Glossitis following the administration of sulphanilamide and sulphathiazole; report of two cases. (18120886)
1949
44
Stomatitis with glossitis following oral therapy with penicillin tablets. (18871405)
1948
45
Chronic Superficial Glossitis with Black "Fur". (19986544)
1928
46
Traumatic Glossitis due to Irritants Contained in Plastic Denture Materials. (20316750)
1928
47
LOCAL APPLICATION OF SALVARSAN IN CHRONIC SUPERFICIAL GLOSSITIS. (20766271)
1912
48
Chronic Glossitis.? Cause. (19975130)
1911
49
The Microscopic Anatomy of the Smooth Tongue, "Chronic Superficial Glossitis.". (20896516)
1878
50
Two Cases of Glossitis. (20794069)
1846

Genetic Variations for Glossitis

Expression for genes affiliated with Glossitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for genes affiliated with Glossitis

Sources:
30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Glossitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL1B
29.8IL6, IL1B
39.8IL1B, TNF
49.8IL1B, TNF
59.8IL6, TNF
69.6LMBRD1, GIF
79.6LMBRD1, GIF
89.4IL6, IL1B, TNF
99.4IL6, IL1B, TNF
109.4IL6, IL1B, TNF
119.4IL6, IL1B, TNF
12
Development PDGF signaling via STATs and NF-kB
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9.4IL6, IL1B, TNF
13
Hide members
9.4IL6, IL1B, TNF
149.4IL6, IL1B, TNF
15
Hide members
9.4IL6, IL1B, TNF
16
Immune response Bacterial infections in normal airways
Hide members
9.4IL6, IL1B, TNF
17
Hide members
9.4IL6, IL1B, TNF
189.4TNF, IL1B, IL6
19
Hide members
9.4TNF, IL1B, IL6
209.4TNF, IL1B, IL6
219.4TNF, IL1B, IL6
229.4TNF, IL1B, IL6
23
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.4TNF, IL1B, IL6
249.4TNF, IL1B, IL6
259.4TNF, IL1B, IL6
269.4TNF, IL1B, IL6
279.4TNF, IL1B, IL6
28
Hide members
9.4TNF, IL1B, IL6
299.4TNF, IL1B, IL6

Compounds for genes affiliated with Glossitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Glossitis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.5TNF
2anisomycin45 1111.4IL6
3muramyl tripeptide phosphatidylethanolamine4510.2IL6, IL1B
4turpentine4510.2IL1B, IL6
5tocilizumab45 1111.1TNF, IL6
6abatacept45 1111.1TNF, IL6
7cdp5714510.1IL6, TNF
8bucillamine4510.0IL6, IL1B
9n,n-dimethylsphingosine45 6011.0IL1B, TNF
10cicaprost45 2910.9TNF, IL1B
11anakinra45 1110.9TNF, IL1B, IL6
12taurine chloramine459.9TNF, IL1B, IL6
13vesnarinone459.9TNF, IL1B, IL6
14mip 1alpha459.9IL6, IL1B, TNF
15il-12459.9TNF, IL1B, IL6
16tpck459.9IL6, IL1B, TNF
17polymyxin b459.9IL6, IL1B, TNF
18groalpha459.9TNF, IL1B, IL6
19leflunomide50 45 1111.9TNF, IL1B, IL6
20triptolide459.9IL6, IL1B, TNF
21ciglitazone45 2910.9TNF, IL1B, IL6
22lipoteichoic acid459.9IL6, IL1B, TNF
23polyinosinic-polycytidylic acid459.8TNF, IL1B, IL6
24etanercept45 50 1111.8TNF, IL1B, IL6
25poly(i-c)459.8IL6, IL1B, TNF
26il 10459.8IL6, IL1B, TNF
27gabexate mesilate459.8IL6, TNF
28infliximab45 50 1111.8IL6, IL1B, TNF
29peptidoglycan45 2910.8IL6, IL1B, TNF
30ivig459.8TNF, IL1B, IL6
31ccl345 2910.8IL6, IL1B, TNF
32toxin-1459.8IL1B, TNF
3315-deoxy-delta-12,14-prostaglandin j2459.8TNF, IL1B, IL6
34pdtc459.7IL6, IL1B, TNF
35thalidomide45 50 60 1112.7IL6, IL1B, TNF
36leukotriene b445 60 2411.7TNF, IL1B, IL6
37sp 60012545 6010.6IL6, IL1B, TNF
38melphalan45 1110.6TNF, IL6, TTR
39pioglitazone45 50 29 1112.6IL6, TNF, GCG
40hydrocortisone45 2 60 1112.5IL6, IL1B, TNF
41hbd2459.5IL6, IL1B
42troglitazone45 29 60 1112.4TNF, IL1B, IL6
43neopterin459.4TTR, IL6, IL1B, TNF
44indomethacin45 60 29 1112.3IL6, IL1B, TNF, GCG
45sb 20358045 6010.3IL6, IL1B, TNF, GCG
46histamine45 29 2411.2GCG, TNF, IL1B, IL6
47pd 98,059459.2GCG, TNF, IL1B, IL6
48ly294002459.2IL6, IL1B, TNF, GCG
49genistein45 29 60 2 11 2413.8GCG, TNF, IL1B, IL6, TTR
50lactate458.6TTR, IL6, TNF, GCG

GO Terms for genes affiliated with Glossitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0TNF, GIF, IL1B, IL6, TTR, GCG
2extracellular spaceGO:0056157.7TTR, IL6, IL1B, GIF, TNF, GCG

Biological processes related to Glossitis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1TNF, IL1B
2sequestering of triglycerideGO:03073010.1TNF, IL1B
3positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
4positive regulation of fever generationGO:03162210.1TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:04508010.1IL1B, TNF
6ectoderm developmentGO:00739810.1KRT6B, KRT6A
7epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1TNF, IL6
8negative regulation of lipid storageGO:01088810.1TNF, IL6
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.1IL1B, TNF
10positive regulation of membrane protein ectodomain proteolysisGO:05104410.0TNF, IL1B
11negative regulation of lipid catabolic processGO:05099510.0IL1B, TNF
12positive regulation of chemokine productionGO:03272210.0IL6, TNF
13positive regulation of NF-kappaB import into nucleusGO:0423469.9TNF, IL1B
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.8IL6, IL1B, TNF
16positive regulation of interleukin-6 productionGO:0327559.8IL6, IL1B, TNF
17positive regulation of mitosisGO:0458409.8TNF, IL1B
18protein kinase B signaling cascadeGO:0434919.8IL1B, TNF
19positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8IL6, IL1B, TNF
20cobalamin metabolic processGO:0092359.7LMBRD1, GIF
21positive regulation of NF-kappaB transcription factor activityGO:0510929.7IL6, IL1B, TNF
22lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, IL1B
23positive regulation of peptidyl-serine phosphorylationGO:0331389.6IL6, TNF, GCG
24regulation of insulin secretionGO:0507969.6IL1B, TNF, GCG
25positive regulation of ERK1 and ERK2 cascadeGO:0703749.5GCG, TNF, IL6
26cellular response to organic cyclic compoundGO:0714079.5IL1B, TNF

Molecular functions related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL6, IL1B, TNF
2cobalamin bindingGO:0314199.3LMBRD1, GIF

Products for genes affiliated with Glossitis

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  • Antibodies

Sources for Glossitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet