MCID: GLS007
MIFTS: 47

Glossitis malady

Gastrointestinal diseases category

Summaries for Glossitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

MalaCards: Glossitis, also known as glossitis nos, is related to median rhomboid glossitis and malaria. An important gene associated with Glossitis is KRT6B (keratin 6B), and among its related pathways are Legionellosis and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gm-csf and anisomycin have been mentioned in the context of this disorder. Affiliated tissues include tongue, endothelial and monocytes, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Glossitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

glossitis 8 10 60
glossitis nos 8


External Ids:

Disease Ontology8 DOID:1456
MeSH34 D005928
ICD9CM27 529.0
ICD1025 K14.0

Related Diseases for Glossitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Glossitis:



Diseases related to glossitis

Clinical Features for Glossitis

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Drugs & Therapeutics for Glossitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Glossitis

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Anatomical Context for Glossitis

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32MalaCards
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MalaCards organs/tissues related to Glossitis:

32
Tongue, Endothelial, Monocytes, Lung, Liver, Colon, Heart, Spinal cord, Bone, Bone marrow

Animal Models for Glossitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Glossitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7KRT6B, KRT6A, IL6, TNF, GCG

Publications for Glossitis

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50PubMed
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Articles related to Glossitis:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). (24236384)
2013
2
Matched case-control study to examine association of psoriasis and migratory glossitis in India. (23254730)
2013
3
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. (24060545)
2013
4
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. (23130817)
2013
5
An apple a day ... chronic glossitis in a 4-year-old boy. (22768729)
2012
6
A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine. (22918478)
2012
7
Herpetic geometric glossitis: acyclovir resistant case in a patient with acute myelogenous leukemia. (20090244)
2010
8
Oral pathology. Benign migratory glossitis. (20806635)
2010
9
Herpetic geometric glossitis in an immunocompetent patient with pneumonia. (19539852)
2009
10
Recurrent Trichosporon asahii glossitis: a case report. (18335127)
2008
11
Successful treatment with cyclosporin administration for persistent benign migratory glossitis. (17408445)
2007
12
Glossitis and tongue trauma subsequent to administration of an oral medication, using an udder infusion cannula, in a horse. (17824329)
2007
13
Diagnostic quiz. Case No. 1: median rhomboid glossitis. (17632961)
2006
14
Helicobacter pylori associated with glossitis and halitosis. (16104947)
2005
15
Kaposi's sarcoma of the tongue associated with median rhomboid glossitis in a non-AIDS patient. A case report. (15274372)
2004
16
Taste disorder involving Hunter's glossitis following total gastrectomy. (12132615)
2002
17
Folate and vitamin B12 levels in patients with oral lichen planus, stomatitis or glossitis. (11944731)
2001
18
The association between atrophic glossitis and protein-calorie malnutrition in old age. (10690695)
2000
19
Herpetic geometric glossitis in a pediatric patient with acute myelogenous leukemia. (9391541)
1997
20
Glossitis, stomatitis, and black tongue with lansoprazole plus clarithromycin and other antibiotics. (9416400)
1997
21
Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. (8949427)
1996
22
Median rhomboid glossitis and a "kissing" lesion of the palate. (8936507)
1996
23
Herpetic geometric glossitis: a distinctive pattern of lingual herpes simplex virus infection. (7502116)
1995
24
Polycythaemia rubra vera presenting with severe glossitis. (7831188)
1994
25
Nutritional correlates of atrophic glossitis: possible role of vitamin E in papillary atrophy. (8440811)
1993
26
Symptomatic benign migratory glossitis: report of two cases and literature review. (1303549)
1992
27
Laboratory measurements of nutritional status as correlates of atrophic glossitis. (1902511)
1991
28
Acute atrophic glossitis after open-heart surgery. (3406691)
1988
29
Median rhomboid glossitis in an infant. Report of a case. (3861810)
1985
30
Radiographic contrast medium--induced glossitis. (3970636)
1985
31
Chronic candidiasis of the rat tongue: a possible model for human median rhomboid glossitis. (6958728)
1982
32
Benign migratory glossitis and allergy. (6963406)
1982
33
Prevalence of glossitis and angular stomatitis in urban women from low income group. (7309196)
1981
34
Doxepin-induced acute glossitis. (7211862)
1980
35
Acute glossitis and septicemia owing to Haemophilus influenzae Type B. (6965336)
1980
36
Median rhomboid glossitis associated with amyloid deposition. (676752)
1978
37
Pasteurella multocida from canine and feline teeth, with a case report of glossitis calcinosa in a dog caused by P. multocida. (693275)
1978
38
Median rhomboid glossitis. Candidiasis and not a developmental anomaly. (1201190)
1975
39
Glossitis of military working dogs in South Vietnam: history and clinical characteristics. (4721764)
1973
40
Hereditary component in the etiology of benign migratory glossitis. (5016506)
1972
41
Median rhomboid glossitis: a developmental anomaly? (5275506)
1971
42
Incidence of geographic tongue and median rhomboid glossitis in 3,319 Negro college students. (5245682)
1968
43
Median rhomboid glossitis: an atypical variant. (5234276)
1967
44
Monocytic leukemic glossitis. Report of a case. (5215982)
1966
45
MAY-HEGGLIN ANOMALY ASSOCIATED WITH GLOSSITIS, PHARYNGITIS AND MUSCULAR HYPOTONIA. (14208037)
1964
46
Glossitis. (13417962)
1957
47
The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. (13088005)
1953
48
Median rhomboid glossitis; report of a case. (13013723)
1952
49
A note on tryptophane and pellagrous glossitis. (14861512)
1951
50
Glossitis and stomatitis without anemia, responding to folic acid and vitamin B12. (14884263)
1951

Genetic Variations for Glossitis

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Expression for genes affiliated with Glossitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for genes affiliated with Glossitis

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 53Reactome
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Pathways related to Glossitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL1B
29.8IL6, IL1B
39.8IL1B, TNF
49.8IL1B, TNF
59.8IL6, TNF
69.6LMBRD1, GIF
79.6LMBRD1, GIF
89.4IL6, IL1B, TNF
99.4IL6, IL1B, TNF
109.4IL6, IL1B, TNF
119.4IL6, IL1B, TNF
12
Development PDGF signaling via STATs and NF-kB
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9.4IL6, IL1B, TNF
13
Hide members
9.4IL6, IL1B, TNF
149.4IL6, IL1B, TNF
15
Hide members
9.4IL6, IL1B, TNF
16
Immune response Bacterial infections in normal airways
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9.4IL6, IL1B, TNF
17
Hide members
9.4IL6, IL1B, TNF
189.4TNF, IL1B, IL6
19
Hide members
9.4TNF, IL1B, IL6
209.4TNF, IL1B, IL6
219.4TNF, IL1B, IL6
229.4TNF, IL1B, IL6
23
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.4TNF, IL1B, IL6
249.4TNF, IL1B, IL6
259.4TNF, IL1B, IL6
269.4TNF, IL1B, IL6
279.4TNF, IL1B, IL6
28
Hide members
9.4TNF, IL1B, IL6
299.4TNF, IL1B, IL6

Compounds for genes affiliated with Glossitis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Glossitis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.5TNF
2anisomycin44 1111.4IL6
3muramyl tripeptide phosphatidylethanolamine4410.2IL6, IL1B
4turpentine4410.2IL6, IL1B
5tocilizumab44 1111.1TNF, IL6
6abatacept44 1111.1IL6, TNF
7cdp5714410.1IL6, TNF
8bucillamine4410.0IL1B, IL6
9n,n-dimethylsphingosine44 5911.0IL1B, TNF
10cicaprost44 2810.9TNF, IL1B
11anakinra44 1110.9TNF, IL1B, IL6
12vesnarinone449.9IL1B, TNF, IL6
13taurine chloramine449.9TNF, IL1B, IL6
14mip 1alpha449.9TNF, IL6, IL1B
15il-12449.9TNF, IL1B, IL6
16tpck449.9IL1B, TNF, IL6
17polymyxin b449.9TNF, IL1B, IL6
18groalpha449.9IL1B, TNF, IL6
19leflunomide49 44 1111.9TNF, IL1B, IL6
20triptolide449.9IL6, TNF, IL1B
21ciglitazone44 2810.9IL1B, TNF, IL6
22lipoteichoic acid449.9IL1B, IL6, TNF
23polyinosinic-polycytidylic acid449.8IL1B, IL6, TNF
24etanercept44 49 1111.8TNF, IL1B, IL6
25poly(i-c)449.8IL6, IL1B, TNF
26il 10449.8IL1B, TNF, IL6
27gabexate mesilate449.8TNF, IL6
28infliximab44 49 1111.8IL1B, TNF, IL6
29peptidoglycan44 2810.8IL1B, TNF, IL6
30hbd2449.8IL6, IL1B
31ivig449.8IL6, TNF, IL1B
32ccl344 2810.8IL1B, TNF, IL6
3315-deoxy-delta-12,14-prostaglandin j2449.8TNF, IL1B, IL6
34pdtc449.7IL1B, IL6, TNF
35thalidomide44 49 59 1112.7TNF, IL1B, IL6
36leukotriene b444 59 2411.7IL6, IL1B, TNF
37sp 60012544 5910.6IL1B, TNF, IL6
38melphalan44 1110.6IL6, TTR, TNF
39pioglitazone44 49 28 1112.6IL6, TNF, GCG
40hydrocortisone44 2 59 1112.5IL6, TNF, IL1B
41toxin-1449.5TNF, IL1B
42troglitazone44 28 59 1112.4IL6, IL1B, TNF
43neopterin449.4TNF, IL1B, IL6, TTR
44indomethacin44 59 28 1112.3IL1B, TNF, GCG, IL6
45sb 20358044 5910.3GCG, TNF, IL1B, IL6
46histamine44 28 2411.2GCG, TNF, IL1B, IL6
47pd 98,059449.2TNF, GCG, IL6, IL1B
48ly294002449.2GCG, TNF, IL1B, IL6
49genistein44 28 59 2 11 2413.8GCG, TNF, TTR, IL6, IL1B
50lactate448.6GCG, IL6, TTR, TNF

GO Terms for genes affiliated with Glossitis

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16Gene Ontology
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Cellular components related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0TNF, GIF, IL1B, IL6, TTR, GCG
2extracellular spaceGO:0056157.7TTR, IL6, IL1B, GIF, TNF, GCG

Biological processes related to Glossitis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1TNF, IL1B
2sequestering of triglycerideGO:03073010.1TNF, IL1B
3positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
4positive regulation of fever generationGO:03162210.1TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:04508010.1IL1B, TNF
6ectoderm developmentGO:00739810.1KRT6B, KRT6A
7epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1TNF, IL6
8negative regulation of lipid storageGO:01088810.1TNF, IL6
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.1IL1B, TNF
10positive regulation of membrane protein ectodomain proteolysisGO:05104410.0TNF, IL1B
11negative regulation of lipid catabolic processGO:05099510.0IL1B, TNF
12positive regulation of chemokine productionGO:03272210.0IL6, TNF
13positive regulation of NF-kappaB import into nucleusGO:0423469.9TNF, IL1B
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.8IL6, IL1B, TNF
16positive regulation of interleukin-6 productionGO:0327559.8IL6, IL1B, TNF
17positive regulation of mitosisGO:0458409.8TNF, IL1B
18protein kinase B signaling cascadeGO:0434919.8IL1B, TNF
19positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8IL6, IL1B, TNF
20cobalamin metabolic processGO:0092359.7LMBRD1, GIF
21positive regulation of NF-kappaB transcription factor activityGO:0510929.7IL6, IL1B, TNF
22lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, IL1B
23positive regulation of peptidyl-serine phosphorylationGO:0331389.6IL6, TNF, GCG
24regulation of insulin secretionGO:0507969.6IL1B, TNF, GCG
25positive regulation of ERK1 and ERK2 cascadeGO:0703749.5GCG, TNF, IL6
26cellular response to organic cyclic compoundGO:0714079.5IL1B, TNF

Molecular functions related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL6, IL1B, TNF
2cobalamin bindingGO:0314199.3LMBRD1, GIF

Products for genes affiliated with Glossitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glossitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet