MCID: GLS007
MIFTS: 44

Glossitis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Glossitis

Aliases & Descriptions for Glossitis:

Name: Glossitis 12 29 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1456
ICD10 33 K14.0
ICD9CM 35 529.0
MeSH 42 D005928
NCIt 47 C112199
UMLS 69 C0017675

Summaries for Glossitis

MalaCards based summary : Glossitis is related to median rhomboid glossitis and atrophic glossitis, and has symptoms including glossalgia and burning tongue. An important gene associated with Glossitis is KRT6B (Keratin 6B), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Amoxicillin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include tongue, lung and monocytes, and related phenotypes are digestive/alimentary and integument

Wikipedia : 71 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

Related Diseases for Glossitis

Diseases related to Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
id Related Disease Score Top Affiliating Genes
1 median rhomboid glossitis 12.3
2 atrophic glossitis 12.0
3 geographic tongue 11.8
4 plummer vinson syndrome 11.1
5 methylmalonic aciduria and homocystinuria, cblf type 10.8
6 tongue disease 10.8
7 rete testis adenocarcinoma 10.2 IL36RN TTR
8 benign hypertensive renal disease 10.2 KRT16 KRT6A
9 chronic mountain sickness 10.2 KRT16 KRT17
10 dicrocoeliasis 10.2 KRT16 KRT17
11 white sponge nevus 1 10.2 KRT16 KRT17
12 craniodiaphyseal dysplasia, autosomal dominant 10.2 KRT16 KRT17
13 cataract 10.2 TNF TTR
14 brachydactyly small stature face anomalies 10.2 KRT16 KRT17
15 hematocele of tunica vaginalis testis 10.1 TNF TTR
16 distal arthrogryposis 10.1 KRT16 KRT17
17 cerebellar disease 10.1 KRT16 TNF
18 occupational dermatitis 10.1 IL36RN TNF
19 toxic megacolon 10.1 KRT6A TNF
20 radial defect robin sequence 10.1 IL36RN TNF
21 nephronophthisis 1, juvenile 10.1 IL36RN TNF
22 inner ear disease 10.1 IL6 TTR
23 scott syndrome 10.1 KRT16 KRT6A KRT6B
24 epidermolysis bullosa simplex-mp 10.1 KRT16 KRT6A KRT6B
25 stomatitis 10.1
26 cholesteatoma of middle ear 10.0 IL36RN KRT6A KRT6B
27 sclerosteosis 1 10.0 KRT16 KRT17 KRT6B
28 cataract 15, multiple types 10.0 KRT16 KRT17 KRT6A
29 acute cor pulmonale 10.0 IL36RN IL6
30 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.0 IL6 TNF
31 dyslexia 5 10.0 IL6 TNF
32 aortic atherosclerosis 10.0 IL6 TNF
33 degenerative disc disease 10.0 IL6 TNF
34 unilateral multicystic dysplastic kidney 10.0 IL6 TNF
35 thymic neuroendocrine carcinoma 10.0 IL6 TNF
36 swine influenza 10.0 IL6 TNF
37 drug dependence 10.0 IL6 TNF
38 transient tic disorder 10.0 IL6 TNF
39 anal paget's disease 10.0 IL6 TNF
40 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.0 IL6 TNF
41 bipolar i disorder 10.0 IL6 TNF
42 aortic coarctation 10.0 IL6 TNF
43 preaxial polydactyly of fingers 10.0 IL6 TNF
44 human immunodeficiency virus infectious disease 10.0 IL6 TNF
45 esophagus lymphoma 10.0 IL6 TNF
46 vogt-koyanagi-harada disease 10.0 IL6 TNF
47 tinea capitis 10.0 IL6 TNF
48 clostridium difficile colitis 10.0 IL6 TNF
49 measles 10.0 IL6 TNF
50 dextrocardia 10.0 IL6 TNF

Comorbidity relations with Glossitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Oral Candidiasis

Graphical network of the top 20 diseases related to Glossitis:



Diseases related to Glossitis

Symptoms & Phenotypes for Glossitis

UMLS symptoms related to Glossitis:


glossalgia, burning tongue

MGI Mouse Phenotypes related to Glossitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 KRT17 KRT6B TNF IL6 KRT16
2 integument MP:0010771 9.1 IL36RN IL6 KRT16 KRT17 KRT6B TNF

Drugs & Therapeutics for Glossitis

Drugs for Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5 penicillins Phase 4
6 cefuroxime axetil Phase 4
7 Anti-Bacterial Agents Phase 4
8 Anti-Infective Agents Phase 4
9 Antimalarials Phase 4
10 Antibiotics, Antitubercular Phase 4
11 Antiparasitic Agents Phase 4
12 Antiprotozoal Agents Phase 4
13
Iron Approved 7439-89-6 23925
14
Ceftriaxone Approved 73384-59-5 5479530 5361919
15
leucovorin Approved, Nutraceutical 58-05-9 54575, 6560146 143
16
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
17 Hematinics
18 Trace Elements
19 Vitamin B Complex
20 Vitamins
21 Immunoglobulins
22 Antibodies
23 Micronutrients
24 Autoantibodies
25 Antitubercular Agents
26 Folate Nutraceutical
27 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4
3 Lyme Borreliosis and Early Cutaneous Diagnostic Unknown status NCT02414789
4 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
5 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715
6 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754
7 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708
8 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Recruiting NCT01931293
9 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249
10 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994
11 Analysis of Lyme Disease Lesions Recruiting NCT00132327

Search NIH Clinical Center for Glossitis

Cochrane evidence based reviews: glossitis

Genetic Tests for Glossitis

Genetic tests related to Glossitis:

id Genetic test Affiliating Genes
1 Glossitis 29

Anatomical Context for Glossitis

MalaCards organs/tissues related to Glossitis:

39
Tongue, Lung, Monocytes, Endothelial, Bone, Liver, Colon

Publications for Glossitis

Articles related to Glossitis:

(show top 50) (show all 214)
id Title Authors Year
1
Host and clinical aspects in patients with benign migratory glossitis. ( 27810384 )
2017
2
Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. ( 27839675 )
2016
3
A Rare Case of Glossitis due to Pasteurella multocida after a Cat Scratch. ( 27840749 )
2016
4
Rhomboid glossitis caused by candida? ( 27200118 )
2016
5
Nodular granulomatous glossitis as the sole clinical sign in canine leishmaniosis. ( 27755675 )
2016
6
Waxing and waning eczematous dermatitis andA glossitis. ( 25773429 )
2015
7
Median rhomboid glossitis-developmental or candidal? ( 26523164 )
2015
8
Environmental factors in benign migratory glossitis and psoriasis: Retrospective study of the association of emotional stress and alcohol and tobacco consumption with benign migratory glossitis and cutaneous psoriasis. ( 25073550 )
2014
9
Fungiform papillary glossitis. ( 24581085 )
2014
10
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. ( 24966760 )
2014
11
Diagnostic discussion. Median rhomboid glossitis (MRG). ( 24579425 )
2013
12
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
13
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. ( 24060545 )
2013
14
Benign migratory glossitis. ( 24413515 )
2013
15
Clinical pathologic conference case 5: Unusual severe glossitis. ( 23738346 )
2013
16
Matched case-control study to examine association of psoriasis and migratory glossitis in India. ( 23254730 )
2013
17
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. ( 23130817 )
2013
18
Glossitis secondary to vitamin B12 deficiency anemia. ( 23359038 )
2013
19
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. ( 22188475 )
2012
20
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. ( 22762365 )
2012
21
Benign migratory glossitis with fissured tongue. ( 22918106 )
2012
22
An apple a day ... chronic glossitis in a 4-year-old boy. ( 22768729 )
2012
23
A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine. ( 22918478 )
2012
24
Median rhomboid glossitis: a clinical and microbiological study. ( 21912494 )
2011
25
Median rhomboid glossitis. ( 21446620 )
2011
26
The development and inflammatory features of radiotherapy-induced glossitis in rats. ( 21196832 )
2011
27
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. ( 22737518 )
2011
28
Taste evaluation in adolescents and pediatric patients with benign migratory glossitis. ( 21802154 )
2011
29
The correlation between the severity of radiotherapy-induced glossitis and endothelial cell injury in local tissues in a rat model. ( 21196860 )
2011
30
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. ( 20339702 )
2010
31
Herpetic geometric glossitis: acyclovir resistant case in a patient with acute myelogenous leukemia. ( 20090244 )
2010
32
Predisposition of allergy in patients with benign migratory glossitis. ( 20674406 )
2010
33
Oral pathology. Benign migratory glossitis. ( 20806635 )
2010
34
Unusual coexistence of oral lymphoepithelial cyst and benign migratory glossitis. ( 19575124 )
2009
35
Glossitis with linear lesions: an early sign of vitamin B12 deficiency. ( 19231648 )
2009
36
Herpetic geometric glossitis in an immunocompetent patient with pneumonia. ( 19539852 )
2009
37
The prevalence and risk factors associated with benign migratory glossitis lesions in 7619 Turkish dental outpatients. ( 19138635 )
2009
38
A classic case of median rhomboid glossitis. ( 19601454 )
2009
39
Recurrent Trichosporon asahii glossitis: a case report. ( 18335127 )
2008
40
Images in clinical medicine. Herpetic glossitis. ( 17881747 )
2007
41
Glossitis and tongue trauma subsequent to administration of an oral medication, using an udder infusion cannula, in a horse. ( 17824329 )
2007
42
Clinical challenge. Tongue--multifocal pyogranulomatous glossitis. ( 18229872 )
2007
43
Successful treatment with cyclosporin administration for persistent benign migratory glossitis. ( 17408445 )
2007
44
Median rhomboid glossitis. ( 17990677 )
2007
45
Atrophic glossitis leading to the diagnosis of celiac disease. ( 17568041 )
2007
46
Investigation of functional gene polymorphisms: IL-1B, IL-6 and TNFA in benign migratory glossitis in Brazilian individuals. ( 17850436 )
2007
47
Partial atrophic tongue other than median rhomboid glossitis. ( 17441970 )
2007
48
Primary tuberculous glossitis in an immunocompetent patient. ( 17664540 )
2007
49
Pachyonychia congenita associated with median rhomboid glossitis. ( 17511954 )
2007
50
Persisting afebrile swelling of the lips and tongue: an unusual case of granulomatous glossitis. ( 16443435 )
2006

Variations for Glossitis

Expression for Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for Glossitis

GO Terms for Glossitis

Cellular components related to Glossitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.92 KRT16 KRT17 KRT6A KRT6B

Biological processes related to Glossitis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 IL36RN IL6 KRT16 TNF
2 cytoskeleton organization GO:0007010 9.63 KRT16 KRT6A KRT6B
3 negative regulation of fat cell differentiation GO:0045599 9.52 IL6 TNF
4 positive regulation of interleukin-6 production GO:0032755 9.51 IL6 TNF
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.49 IL6 TNF
6 negative regulation of interleukin-6 production GO:0032715 9.48 IL36RN TNF
7 intermediate filament cytoskeleton organization GO:0045104 9.43 KRT16 KRT6A
8 positive regulation of chemokine production GO:0032722 9.4 IL6 TNF
9 negative regulation of lipid storage GO:0010888 9.32 IL6 TNF
10 positive regulation of hair follicle development GO:0051798 9.26 KRT17 TNF
11 keratinization GO:0031424 9.26 KRT16 KRT17 KRT6A KRT6B
12 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.16 IL6 TNF
13 cornification GO:0070268 8.92 KRT16 KRT17 KRT6A KRT6B

Molecular functions related to Glossitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.33 KRT16 KRT17 KRT6A
2 cytokine activity GO:0005125 9.13 IL36RN IL6 TNF
3 structural constituent of cytoskeleton GO:0005200 8.92 KRT16 KRT17 KRT6A KRT6B

Sources for Glossitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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