MCID: GLS007
MIFTS: 51

Glossitis malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Glossitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

MalaCards: Glossitis, also known as glossitis nos, is related to median rhomboid glossitis and psoriasis. An important gene associated with Glossitis is KRT6B (keratin 6B), and among its related pathways are Th17 Differentiation and Selected targets of GCR alpha. The compounds muramyl tripeptide phosphatidylethanolamine and turpentine have been mentioned in the context of this disorder. Affiliated tissues include tongue, endothelial and monocytes, and related mouse phenotypes are digestive/alimentary and mortality/aging.

Aliases & Classifications for Glossitis

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9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

glossitis 9 11 63
glossitis nos 9


External Ids:

Disease Ontology9 DOID:1456
MeSH36 D005928
ICD9CM28 529.0
ICD1026 K14.0

Related Diseases for Glossitis

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18GeneCards, 19GeneDecks
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Diseases related to Glossitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1median rhomboid glossitis31.2KRT6A, KRT6B, THEM5
2psoriasis30.2IL1B, IL6, TNF
3pneumonia30.1TNF, IL6, IL1B
4malaria30.0TNF
5pachyonychia congenita30.0KRT6A, KRT6B
6leukemia29.9IL1B, IL6, TTR, TNF
7pancreatitis29.9IL6, IL1B, GCG
8atrophic glossitis10.6
9geographic tongue10.5
10stomatitis10.4
11fissured tongue10.3
12cheilitis10.2
13gingivitis10.2
14syphilis10.2
15vitamin b12 deficiency10.2
16degenerative disc disease10.1IL1B
17hereditary mucosal leukokeratosis10.1KRT6A, KRT6B
18crohn's disease10.1TNF
19burns10.1
20lichen planus10.1
21celiac disease10.1
22pernicious anemia10.1
23candidiasis10.1
24herpes simplex10.1
25influenza10.1
26leishmaniasis10.1
27plummer vinson syndrome10.1
28dysphagia10.1
29monilethrix10.1KRT6A, KRT6B
30keratosis10.1KRT6B, KRT6A
31skin disease10.1IL6, IL1B
32euthyroid sick syndrome10.1IL1B, IL6
33poems syndrome10.1IL1B, IL6
34pulmonary disease, chronic obstructive10.0IL6, IL1B
35eye disease10.0IL1B, IL6
36newborn respiratory distress syndrome10.0IL1B, IL6
37blau syndrome10.0TNF, IL1B
38aids dementia complex10.0IL1B, TNF
39familial mediterranean fever10.0IL1B, TNF
40thrombocytosis10.0IL1B, IL6
41acquired immunodeficiency syndrome10.0IL6, IL1B
42interstitial lung disease10.0TNF, IL1B
43psoriatic arthritis10.0TNF, IL1B
44meningitis10.0IL1B, IL6
45cerebral malaria10.0TNF, IL1B
46toxic shock syndrome10.0IL1B, TNF
47juvenile rheumatoid arthritis10.0IL6, TNF
48prion disease10.0IL1B, IL6
49arthropathy10.0IL1B, TNF
50inflammatory bowel disease10.0IL1B, IL6

Graphical network of the top 20 diseases related to Glossitis:



Diseases related to glossitis

Symptoms for Glossitis

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Drugs & Therapeutics for Glossitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Glossitis

Genetic Tests for Glossitis

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Anatomical Context for Glossitis

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34MalaCards
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MalaCards organs/tissues related to Glossitis:

34
Tongue, Endothelial, Monocytes, Lung, Liver, Colon, Heart, Spinal cord, Bone, Bone marrow

Animal Models for Glossitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Glossitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0TNF, IL6, KRT6B, KRT6A, GCG
2MP:00107687.8GCG, KRT6A, KRT6B, IL1B, IL6, TNF
3MP:00053766.6GCG, KRT6A, IL1B, IL6, TTR, TNF

Publications for Glossitis

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53PubMed
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Articles related to Glossitis:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). (24236384)
2013
2
Matched case-control study to examine association of psoriasis and migratory glossitis in India. (23254730)
2013
3
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. (24060545)
2013
4
Clinical pathologic conference case 5: Unusual severe glossitis. (23738346)
2013
5
An apple a day ... chronic glossitis in a 4-year-old boy. (22768729)
2012
6
The development and inflammatory features of radiotherapy-induced glossitis in rats. (21196832)
2011
7
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. (20339702)
2010
8
Successful treatment with cyclosporin administration for persistent benign migratory glossitis. (17408445)
2007
9
Primary tuberculous glossitis in an immunocompetent patient. (17664540)
2007
10
Median rhomboid glossitis. (17990677)
2007
11
Partial atrophic tongue other than median rhomboid glossitis. (17441970)
2007
12
Investigation of functional gene polymorphisms: IL-1B, IL-6 and TNFA in benign migratory glossitis in Brazilian individuals. (17850436)
2007
13
Persisting afebrile swelling of the lips and tongue: an unusual case of granulomatous glossitis. (16443435)
2006
14
Helicobacter pylori associated with glossitis and halitosis. (16104947)
2005
15
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. (15316160)
2004
16
The association between atrophic glossitis and protein-calorie malnutrition in old age. (10690695)
2000
17
Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism. (9674310)
1998
18
Herpetic geometric glossitis in a pediatric patient with acute myelogenous leukemia. (9391541)
1997
19
Cause of median rhomboid glossitis. (8705579)
1996
20
Herpetic geometric glossitis: a distinctive pattern of lingual herpes simplex virus infection. (7502116)
1995
21
Iron status in atrophic glossitis: a pilot study. (8266715)
1993
22
Laboratory measurements of nutritional status as correlates of atrophic glossitis. (1902511)
1991
23
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). (1841980)
1991
24
Severe facial oedema and glossitis associated with mianserin. (2571803)
1989
25
Tobacco smoking and denture wearing as local aetiological factors in median rhomboid glossitis. (6438002)
1984
26
Glossitis and dysgeusia. (6517995)
1984
27
Benign migratory glossitis--a cause for worry? (7334963)
1981
28
Median rhomboid glossitis caused by Candida? (282562)
1979
29
Median rhomboid glossitis associated with amyloid deposition. (676752)
1978
30
Median rhomboid glossitis: not a misnomer. Review of the literature and histologic study of twenty-eight cases. (366496)
1978
31
Carcinoma arising in the area of median rhomboid glossitis. (1063965)
1976
32
Atypical benign migratory glossitis. Report of a case with histologic and electron microscopic evaluations. (1069222)
1976
33
Migratory glossitis. A clinical-histologic review of seventy cases. (1053669)
1975
34
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. (5270895)
1970
35
Median rhomboid glossitis. Case report. (5353692)
1969
36
Median rhomboid glossitis: an atypical variant. (5234276)
1967
37
Monocytic leukemic glossitis. Report of a case. (5215982)
1966
38
Glossitis. (13417962)
1957
39
Glossitis rhombica mediana: a lesion confused with carcinoma. (14367852)
1955
40
Some aspects of the tongue in pellagrous glossitis. (13061600)
1953
41
Syndrome of anemia, dysphagia and glossitis (Plummer Vinson syndrome). (13111401)
1953
42
A case for diagnosis (syphilitic glossitis?). (20287978)
1947
43
Glossitis and stomatitis due to penicillin lozenges and troches. (21016496)
1946
44
Glossitis rhombica mediana? (21064482)
1946
45
Nodular interstitial glossitis due to syphilis. (21005899)
1945
46
Chronic Superficial Glossitis with Black "Fur". (19986544)
1928
47
Glossitis Migrans. (19984958)
1926
48
Glossitis Migrans; a large unknown Coccus present. (19985451)
1926
49
A CASE OF LATE SYPHILITIC GLOSSITIS TREATED BY SALVARSAN (EHRLICH-HATA). (20766080)
1912
50
Two Cases of Glossitis. (20794069)
1846

Variations for Glossitis

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Expression for genes affiliated with Glossitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for genes affiliated with Glossitis

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Sources:
51PathCards, 55R&D Systems, 13EMD Millipore, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome
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Pathways related to Glossitis according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6IL1B, IL6
29.6IL1B, IL6
39.6IL1B, IL6
49.6IL1B, IL6
59.5TNF, IL1B
69.5IL1B, TNF
79.5IL1B, TNF
8
Show member pathways
Serotonin Transporter Activity39
9.5IL1B, TNF
99.5TNF, IL6
109.5IL6, TNF
11
Show member pathways
9.1IL1B, IL6, TNF
12
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.1TNF, IL6, IL1B
139.1IL1B, IL6, TNF
14
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.1IL1B, IL6, TNF
15
Show member pathways
9.1TNF, IL6, IL1B
16
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1IL1B, IL6, TNF
17
Show member pathways
9.1TNF, IL6, IL1B
18
Show member pathways
9.1TNF, IL6, IL1B
199.1TNF, IL6, IL1B
209.1TNF, IL6, IL1B
219.1IL1B, IL6, TNF
22
Show member pathways
9.1IL1B, IL6, TNF
23
Show member pathways
thioredoxin pathway39
9.1TNF, IL6, IL1B
249.1TNF, IL6, IL1B
25
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.1IL1B, IL6, TNF
269.1TNF, IL6, IL1B
279.1IL1B, IL6, TNF
289.1TNF, IL6, IL1B
29
Show member pathways
IL27-mediated signaling events39
9.1TNF, IL6, IL1B
309.1TNF, IL6, IL1B
31
Show member pathways
9.1TNF, IL6, IL1B
32
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.1IL1B, IL6, TNF
339.1IL1B, IL6, TNF
349.1TNF, IL6, IL1B
359.1TNF, IL6, IL1B
369.1IL1B, IL6, TNF
37
Show member pathways
Immune response MIF in innate immunity response61
9.1IL1B, IL6, TNF
389.1TNF, IL6, IL1B
399.1TNF, IL6, IL1B

Compounds for genes affiliated with Glossitis

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Glossitis according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1muramyl tripeptide phosphatidylethanolamine4610.0IL1B, IL6
2turpentine469.9IL6, IL1B
3tocilizumab46 1210.8TNF, IL6
4abatacept46 1210.8IL6, TNF
5bucillamine469.7IL1B, IL6
6cdp571469.7TNF, IL6
7tenidap46 3010.5IL1B, IL6, TNF
8anakinra46 1210.5TNF, IL6, IL1B
9taurine chloramine469.5IL1B, IL6, TNF
10vesnarinone469.5IL1B, IL6, TNF
11mip 1alpha469.5TNF, IL6, IL1B
12il-12469.5IL1B, IL6, TNF
13tpck469.5TNF, IL6, IL1B
14polymyxin b469.5IL1B, IL6, TNF
15groalpha469.5TNF, IL6, IL1B
16leflunomide46 52 1211.5TNF, IL6, IL1B
17gm-csf46 3010.5TNF, IL6, IL1B
18triptolide469.5TNF, IL6, IL1B
19ciglitazone46 3010.5TNF, IL6, IL1B
20lipoteichoic acid469.5IL1B, IL6, TNF
21polyinosinic-polycytidylic acid469.5IL1B, IL6, TNF
22etanercept46 52 1211.5TNF, IL6, IL1B
23poly(i-c)469.5IL1B, IL6, TNF
24il 10469.5IL1B, IL6, TNF
25infliximab46 52 1211.5TNF, IL6, IL1B
26peptidoglycan46 3010.5TNF, IL6, IL1B
27ivig469.5IL1B, IL6, TNF
28ccl346 3010.5TNF, IL6, IL1B
29pentoxifylline46 1210.4TNF, IL6, IL1B
3015-deoxy-delta-12,14-prostaglandin j2469.4IL1B, IL6, TNF
31pdtc469.4TNF, IL6, IL1B
32anisomycin46 1210.3TNF, IL6, IL1B
33thalidomide46 52 62 1212.3IL1B, IL6, TNF
34pioglitazone30 46 52 1212.3GCG, IL6, TNF
35leukotriene b446 62 2511.3IL1B, IL6, TNF
36n,n-dimethylsphingosine46 6210.2IL1B, TNF
37sp 60012546 6210.2TNF, IL6, IL1B
38melphalan46 52 1211.2IL6, TTR, TNF
39hydrocortisone46 3 62 1212.2TNF, IL6, IL1B
40troglitazone46 30 62 1212.1IL1B, IL6, TNF
41tgf beta1469.1IL1B, IL6, TNF
42indomethacin46 30 62 1212.0TNF, IL6, IL1B, GCG
43sb 20358046 6210.0TNF, IL6, IL1B, GCG
44neopterin468.9IL1B, IL6, TTR, TNF
45histamine46 30 2510.9TNF, IL6, IL1B, GCG
46pd 98,059468.9TNF, IL6, IL1B, GCG
47ly294002468.9GCG, IL1B, IL6, TNF
48lactate468.6GCG, IL6, TTR, TNF
49cycloheximide468.5TNF, IL6, IL1B, GCG
50genistein46 30 62 3 25 1213.4TNF, TTR, IL6, IL1B, GCG

GO Terms for genes affiliated with Glossitis

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17Gene Ontology
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Cellular components related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9TTR, IL6, IL1B, GCG, TNF
2extracellular spaceGO:0056157.6GCG, IL1B, IL6, TTR, TNF

Biological processes related to Glossitis according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1ectoderm developmentGO:00739810.1KRT6B, KRT6A
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.0TNF, IL1B
3sequestering of triglycerideGO:03073010.0TNF, IL1B
4positive regulation of heterotypic cell-cell adhesionGO:0341169.9TNF, IL1B
5positive regulation of fever generationGO:0316229.9TNF, IL1B
6positive regulation of chemokine biosynthetic processGO:0450809.9IL1B, TNF
7regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.9IL1B, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:0510449.9IL1B, TNF
9negative regulation of lipid catabolic processGO:0509959.9TNF, IL1B
10epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.9TNF, IL6
11positive regulation of NF-kappaB import into nucleusGO:0423469.9IL1B, TNF
12negative regulation of lipid storageGO:0108889.9TNF, IL6
13lipopolysaccharide-mediated signaling pathwayGO:0316639.9IL1B, TNF
14positive regulation of mitosisGO:0458409.9TNF, IL1B
15protein kinase B signalingGO:0434919.9IL1B, TNF
16positive regulation of chemokine productionGO:0327229.8IL6, TNF
17negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, TNF
18cellular response to organic cyclic compoundGO:0714079.8TNF, IL1B
19positive regulation of T cell proliferationGO:0421029.8IL1B, IL6
20positive regulation of interferon-gamma productionGO:0327299.8IL1B, TNF
21defense response to Gram-positive bacteriumGO:0508309.8TNF, IL6
22negative regulation of fat cell differentiationGO:0455999.8TNF, IL6
23positive regulation of smooth muscle cell proliferationGO:0486619.7TNF, IL6
24positive regulation of JNK cascadeGO:0463309.7IL1B, TNF
25response to mechanical stimulusGO:0096129.6IL6, TNF
26humoral immune responseGO:0069599.6TNF, IL6
27MAPK cascadeGO:0001659.5IL1B, TNF
28positive regulation of nitric oxide biosynthetic processGO:0454299.5IL1B, IL6, TNF
29positive regulation of interleukin-6 productionGO:0327559.5TNF, IL6, IL1B
30response to glucocorticoidGO:0513849.5IL6, TNF
31positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5TNF, IL6, IL1B
32positive regulation of NF-kappaB transcription factor activityGO:0510929.5TNF, IL6, IL1B
33regulation of insulin secretionGO:0507969.4GCG, IL1B, TNF
34positive regulation of protein kinase B signalingGO:0518979.4IL6, TNF
35positive regulation of peptidyl-serine phosphorylationGO:0331389.4GCG, IL6, TNF
36positive regulation of ERK1 and ERK2 cascadeGO:0703749.4GCG, IL6, TNF
37inflammatory responseGO:0069549.4IL1B, IL6, TNF
38negative regulation of cell proliferationGO:0082859.3TNF, IL6, IL1B
39positive regulation of transcription, DNA-templatedGO:0458938.8TNF, IL6, IL1B

Molecular functions related to Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.8GCG, TTR, TNF
2cytokine activityGO:0051258.8IL1B, IL6, TNF

Products for genes affiliated with Glossitis

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Sources for Glossitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet