MCID: GLS007
MIFTS: 43

Glossitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Glossitis

MalaCards integrated aliases for Glossitis:

Name: Glossitis 12 29 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1456
ICD10 33 K14.0
ICD9CM 35 529.0
MeSH 42 D005928
NCIt 47 C112199
UMLS 69 C0017675

Summaries for Glossitis

MalaCards based summary : Glossitis is related to dysphagia and median rhomboid glossitis, and has symptoms including glossalgia and burning tongue. An important gene associated with Glossitis is KRT6B (Keratin 6B), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Cefuroxime and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include tongue, lung and liver, and related phenotypes are digestive/alimentary and integument

Wikipedia : 72 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

Related Diseases for Glossitis

Diseases related to Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
id Related Disease Score Top Affiliating Genes
1 dysphagia 29.8 IL6 TNF
2 median rhomboid glossitis 12.3
3 atrophic glossitis 12.0
4 geographic tongue 11.8
5 plummer vinson syndrome 11.1
6 tongue disease 10.8
7 hypertrichosis lanuginosa, acquired 10.8
8 methylmalonic aciduria and homocystinuria, cblf type 10.8
9 cholesteatoma of attic 10.6 KRT6A KRT6B
10 cataract 10.4 TNF TTR
11 hematocele of tunica vaginalis testis 10.4 TNF TTR
12 smarca4-deficient sarcoma of thorax 10.2 IL6 TNF
13 aortic arch interruption 10.2 IL6 TNF
14 cutaneous leishmaniasis 10.2 IL6 TNF
15 spirillary rat-bite fever 10.2 IL6 TNF
16 toxoplasmosis 10.2 IL6 TNF
17 dyslexia 5 10.2 IL6 TNF
18 epstein-barr virus hepatitis 10.2 IL6 TNF
19 scrotal carcinoma 10.2 IL6 TNF
20 anencephaly and spina bifida x-linked 10.2 IL6 TNF
21 antigen-peptide-transporter 2 deficiency 10.2 IL6 TNF
22 ethmoid sinus adenocarcinoma 10.2 IL6 TNF
23 upper gum cancer 10.2 IL6 TNF
24 potato nose 10.2 IL6 TNF
25 bipolar i disorder 10.2 IL6 TNF
26 lymphocytic colitis 10.2 IL6 TNF
27 pasteurellosis 10.2 IL6 TNF
28 tinea favosa 10.2 IL6 TNF
29 central nervous system leiomyosarcoma 10.2 IL6 TNF
30 indolent myeloma 10.2 IL6 TNF
31 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.2 IL6 TNF
32 vogt-koyanagi-harada disease 10.2 IL6 TNF
33 cicatricial lagophthalmos 10.2 IL6 TNF
34 tricho onychic dysplasia 10.2 IL6 TNF
35 phlyctenulosis 10.2 IL6 TNF
36 islet cell tumor 10.2 IL6 TNF
37 cyclosporiasis 10.2 IL6 TNF
38 hypogonadotropism 10.2 IL6 TNF
39 early-onset zonular cataract 10.2 IL6 TNF
40 primary biliary cirrhosis 10.2 IL6 TNF
41 placental abruption 10.2 IL6 TNF
42 hepadnavirus infection 10.2 IL6 TNF
43 tracheal stenosis 10.2 IL6 TNF
44 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.2 IL6 TNF
45 ulcerative colitis 10.2 IL6 TNF
46 acquired thrombocytopenia 10.2 IL6 TNF
47 hemophagocytic lymphohistiocytosis 10.2 IL6 TNF
48 ampulla of vater neoplasm 10.2 IL6 TNF
49 benign neonatal seizures 10.2 IL6 TNF
50 pityriasis rosea 10.2 IL6 TNF

Comorbidity relations with Glossitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Oral Candidiasis

Graphical network of the top 20 diseases related to Glossitis:



Diseases related to Glossitis

Symptoms & Phenotypes for Glossitis

UMLS symptoms related to Glossitis:


glossalgia, burning tongue

MGI Mouse Phenotypes related to Glossitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 IL6 KRT16 KRT17 KRT6B TNF
2 integument MP:0010771 9.02 KRT16 KRT17 KRT6B TNF IL6

Drugs & Therapeutics for Glossitis

Drugs for Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Antimalarials Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10 cefuroxime axetil Phase 4
11 Antibiotics, Antitubercular Phase 4
12 penicillins Phase 4
13
Iron Approved 7439-89-6 23925
14
Ceftriaxone Approved 73384-59-5 5479530 5361919
15
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
16
leucovorin Approved, Nutraceutical 58-05-9 143 6006
17 Antibodies
18 Autoantibodies
19 Hematinics
20 Immunoglobulins
21 Micronutrients
22 Trace Elements
23 Vitamin B Complex
24 Vitamins
25 Antitubercular Agents
26 Folate Nutraceutical
27 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 11)

id Name Status NCT ID Phase Drugs
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
3 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
4 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 doxycycline;doxycycline;placebo
5 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754
6 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
7 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Recruiting NCT01931293
8 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789
9 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249 antibiotic treatment
10 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994 ceftriaxone;doxycycline
11 Analysis of Lyme Disease Lesions Recruiting NCT00132327

Search NIH Clinical Center for Glossitis

Cochrane evidence based reviews: glossitis

Genetic Tests for Glossitis

Genetic tests related to Glossitis:

id Genetic test Affiliating Genes
1 Glossitis 29

Anatomical Context for Glossitis

MalaCards organs/tissues related to Glossitis:

39
Tongue, Lung, Liver, Colon, Bone, Endothelial, Monocytes

Publications for Glossitis

Articles related to Glossitis:

(show top 50) (show all 218)
id Title Authors Year
1
Host and clinical aspects in patients with benign migratory glossitis. ( 27810384 )
2017
2
Rhomboid glossitis in disseminated CMV infection. ( 28331808 )
2017
3
Fungal dermatitis, glossitis and disseminated visceral mycosis caused by different Metarhizium granulomatis genotypes in veiled chameleons (Chamaeleo calyptratus) and first isolation in healthy lizards. ( 28757044 )
2017
4
Mycobacterium abscessus glossitis. ( 28948933 )
2017
5
Rhomboid glossitis caused by candida? ( 27200118 )
2016
6
A Rare Case of Glossitis due to Pasteurella multocida after a Cat Scratch. ( 27840749 )
2016
7
Nodular granulomatous glossitis as the sole clinical sign in canine leishmaniosis. ( 27755675 )
2016
8
Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. ( 27839675 )
2016
9
Waxing and waning eczematous dermatitis andA glossitis. ( 25773429 )
2015
10
Median rhomboid glossitis-developmental or candidal? ( 26523164 )
2015
11
Fungiform papillary glossitis. ( 24581085 )
2014
12
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. ( 24966760 )
2014
13
Environmental factors in benign migratory glossitis and psoriasis: Retrospective study of the association of emotional stress and alcohol and tobacco consumption with benign migratory glossitis and cutaneous psoriasis. ( 25073550 )
2014
14
Clinical pathologic conference case 5: Unusual severe glossitis. ( 23738346 )
2013
15
Benign migratory glossitis. ( 24413515 )
2013
16
Glossitis secondary to vitamin B12 deficiency anemia. ( 23359038 )
2013
17
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
18
Diagnostic discussion. Median rhomboid glossitis (MRG). ( 24579425 )
2013
19
Matched case-control study to examine association of psoriasis and migratory glossitis in India. ( 23254730 )
2013
20
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. ( 24060545 )
2013
21
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. ( 23130817 )
2013
22
An apple a day ... chronic glossitis in a 4-year-old boy. ( 22768729 )
2012
23
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. ( 22762365 )
2012
24
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. ( 22188475 )
2012
25
A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine. ( 22918478 )
2012
26
Benign migratory glossitis with fissured tongue. ( 22918106 )
2012
27
Median rhomboid glossitis: a clinical and microbiological study. ( 21912494 )
2011
28
The correlation between the severity of radiotherapy-induced glossitis and endothelial cell injury in local tissues in a rat model. ( 21196860 )
2011
29
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. ( 22737518 )
2011
30
Taste evaluation in adolescents and pediatric patients with benign migratory glossitis. ( 21802154 )
2011
31
The development and inflammatory features of radiotherapy-induced glossitis in rats. ( 21196832 )
2011
32
Median rhomboid glossitis. ( 21446620 )
2011
33
Oral pathology. Benign migratory glossitis. ( 20806635 )
2010
34
Predisposition of allergy in patients with benign migratory glossitis. ( 20674406 )
2010
35
Herpetic geometric glossitis: acyclovir resistant case in a patient with acute myelogenous leukemia. ( 20090244 )
2010
36
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. ( 20339702 )
2010
37
Glossitis with linear lesions: an early sign of vitamin B12 deficiency. ( 19231648 )
2009
38
Unusual coexistence of oral lymphoepithelial cyst and benign migratory glossitis. ( 19575124 )
2009
39
A classic case of median rhomboid glossitis. ( 19601454 )
2009
40
Herpetic geometric glossitis in an immunocompetent patient with pneumonia. ( 19539852 )
2009
41
The prevalence and risk factors associated with benign migratory glossitis lesions in 7619 Turkish dental outpatients. ( 19138635 )
2009
42
Recurrent Trichosporon asahii glossitis: a case report. ( 18335127 )
2008
43
Primary tuberculous glossitis in an immunocompetent patient. ( 17664540 )
2007
44
Glossitis and tongue trauma subsequent to administration of an oral medication, using an udder infusion cannula, in a horse. ( 17824329 )
2007
45
Successful treatment with cyclosporin administration for persistent benign migratory glossitis. ( 17408445 )
2007
46
Partial atrophic tongue other than median rhomboid glossitis. ( 17441970 )
2007
47
Images in clinical medicine. Herpetic glossitis. ( 17881747 )
2007
48
Pachyonychia congenita associated with median rhomboid glossitis. ( 17511954 )
2007
49
Median rhomboid glossitis. ( 17990677 )
2007
50
Investigation of functional gene polymorphisms: IL-1B, IL-6 and TNFA in benign migratory glossitis in Brazilian individuals. ( 17850436 )
2007

Variations for Glossitis

Expression for Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for Glossitis

GO Terms for Glossitis

Cellular components related to Glossitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.92 KRT16 KRT17 KRT6A KRT6B

Biological processes related to Glossitis according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 cytoskeleton organization GO:0007010 9.67 KRT16 KRT6A KRT6B
2 negative regulation of fat cell differentiation GO:0045599 9.54 IL6 TNF
3 positive regulation of interleukin-6 production GO:0032755 9.52 IL6 TNF
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.51 IL6 TNF
5 intermediate filament cytoskeleton organization GO:0045104 9.46 KRT16 KRT6A
6 positive regulation of chemokine production GO:0032722 9.43 IL6 TNF
7 negative regulation of glucose import GO:0046325 9.4 LMBRD1 TNF
8 negative regulation of lipid storage GO:0010888 9.37 IL6 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.32 IL6 TNF
10 positive regulation of hair follicle development GO:0051798 9.26 KRT17 TNF
11 keratinization GO:0031424 9.26 KRT16 KRT17 KRT6A KRT6B
12 morphogenesis of an epithelium GO:0002009 9.18 KRT16
13 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.16 IL6 TNF
14 cornification GO:0070268 8.92 KRT16 KRT17 KRT6A KRT6B

Molecular functions related to Glossitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 KRT16 KRT17 KRT6A
2 structural constituent of cytoskeleton GO:0005200 8.92 KRT16 KRT17 KRT6A KRT6B

Sources for Glossitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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