MCID: GLS007
MIFTS: 43

Glossitis malady

Gastrointestinal diseases category

Aliases & Classifications for Glossitis

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Glossitis, Aliases & Descriptions:

Name: Glossitis 9 11 60
 
Glossitis Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:1456
ICD9CM27 529.0
MeSH33 D005928
ICD1025 K14.0

Summaries for Glossitis

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Wikipedia:63 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

MalaCards based summary: Glossitis, also known as glossitis nos, is related to median rhomboid glossitis and pachyonychia congenita. An important gene associated with Glossitis is KRT6B (keratin 6B), and among its related pathways are Th17 Differentiation and Selected targets of GCR alpha. The compounds muramyl tripeptide phosphatidylethanolamine and turpentine have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone marrow and bone, and related mouse phenotypes are digestive/alimentary and mortality/aging.

Related Diseases for Glossitis

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Diseases related to Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1median rhomboid glossitis31.4KRT6A, KRT6B, THEM5
2pachyonychia congenita30.3KRT6B, KRT6A
3malaria30.1TNF, IL1B
4psoriasis30.1IL6, IL1B, TNF
5pneumonia30.0IL1B, IL6, TNF
6pancreatitis29.9IL1B, GCG, IL6
7leukemia29.4TTR, TNF, IL6, IL1B
8atrophic glossitis10.5
9geographic tongue10.5
10intervertebral disc disease10.5IL1B
11stomatitis10.4
12crohn's disease10.3TNF
13white sponge nevus 110.3KRT6A, KRT6B
14monilethrix10.3KRT6B, KRT6A
15keratosis10.3KRT6A, KRT6B
16fissured tongue10.3
17skin disease10.2IL1B, IL6
18cheilitis10.2
19euthyroid sick syndrome10.2IL1B, IL6
20poems syndrome10.2IL6, IL1B
21pulmonary disease, chronic obstructive10.2IL6, IL1B
22eye disease10.2IL6, IL1B
23blau syndrome10.2TNF, IL1B
24hartnup disorder10.2
25gingivitis10.2
26syphilis10.2
27vitamin b12 deficiency10.2
28aids dementia complex10.2TNF, IL1B
29thrombocytosis10.2IL6, IL1B
30familial mediterranean fever, ar10.2IL1B, TNF
31acquired immunodeficiency syndrome10.2IL6, IL1B
32interstitial lung disease10.2IL1B, TNF
33meningitis10.2IL1B, IL6
34psoriatic arthritis10.2IL1B, TNF
35toxic shock syndrome10.1TNF, IL1B
36juvenile rheumatoid arthritis10.1TNF, IL6
37arthropathy10.1TNF, IL1B
38folate malabsorption, hereditary10.1
39kawasaki disease10.1
40celiac disease10.1
41acrodermatitis enteropathica10.1
42burns10.1
43lichen planus10.1
44pernicious anemia10.1
45temporal arteritis10.1
46candidiasis10.1
47dermatitis10.1
48herpes simplex10.1
49influenza10.1
50leishmaniasis10.1

Graphical network of the top 20 diseases related to Glossitis:



Diseases related to glossitis

Symptoms for Glossitis

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Drugs & Therapeutics for Glossitis

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Drug clinical trials:

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Search NIH Clinical Center for Glossitis

Genetic Tests for Glossitis

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Anatomical Context for Glossitis

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MalaCards organs/tissues related to Glossitis:

31
Tongue, Bone marrow, Bone, Spinal cord, Heart, Colon, Liver, Lung, Monocytes, Endothelial

Animal Models for Glossitis or affiliated genes

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MGI Mouse Phenotypes related to Glossitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.0TNF, IL6, KRT6B, KRT6A, GCG
2MP:00107687.8GCG, KRT6A, KRT6B, IL1B, IL6, TNF
3MP:00053766.6GCG, KRT6A, IL1B, IL6, TTR, TNF

Publications for Glossitis

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Articles related to Glossitis:

(show top 50)    (show all 206)
idTitleAuthorsYear
1
Matched case-control study to examine association of psoriasis and migratory glossitis in India. (23254730)
2013
2
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. (24060545)
2013
3
Clinical pathologic conference case 5: Unusual severe glossitis. (23738346)
2013
4
An apple a day ... chronic glossitis in a 4-year-old boy. (22768729)
2012
5
The development and inflammatory features of radiotherapy-induced glossitis in rats. (21196832)
2011
6
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. (20339702)
2010
7
Successful treatment with cyclosporin administration for persistent benign migratory glossitis. (17408445)
2007
8
Primary tuberculous glossitis in an immunocompetent patient. (17664540)
2007
9
Median rhomboid glossitis. (17990677)
2007
10
Partial atrophic tongue other than median rhomboid glossitis. (17441970)
2007
11
Investigation of functional gene polymorphisms: IL-1B, IL-6 and TNFA in benign migratory glossitis in Brazilian individuals. (17850436)
2007
12
Persisting afebrile swelling of the lips and tongue: an unusual case of granulomatous glossitis. (16443435)
2006
13
Helicobacter pylori associated with glossitis and halitosis. (16104947)
2005
14
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. (15316160)
2004
15
The association between atrophic glossitis and protein-calorie malnutrition in old age. (10690695)
2000
16
Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism. (9674310)
1998
17
Herpetic geometric glossitis in a pediatric patient with acute myelogenous leukemia. (9391541)
1997
18
Cause of median rhomboid glossitis. (8705579)
1996
19
Herpetic geometric glossitis: a distinctive pattern of lingual herpes simplex virus infection. (7502116)
1995
20
Iron status in atrophic glossitis: a pilot study. (8266715)
1993
21
Laboratory measurements of nutritional status as correlates of atrophic glossitis. (1902511)
1991
22
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report). (1841980)
1991
23
Severe facial oedema and glossitis associated with mianserin. (2571803)
1989
24
Tobacco smoking and denture wearing as local aetiological factors in median rhomboid glossitis. (6438002)
1984
25
Glossitis and dysgeusia. (6517995)
1984
26
Benign migratory glossitis--a cause for worry? (7334963)
1981
27
Median rhomboid glossitis caused by Candida? (282562)
1979
28
Median rhomboid glossitis associated with amyloid deposition. (676752)
1978
29
Median rhomboid glossitis: not a misnomer. Review of the literature and histologic study of twenty-eight cases. (366496)
1978
30
Carcinoma arising in the area of median rhomboid glossitis. (1063965)
1976
31
Atypical benign migratory glossitis. Report of a case with histologic and electron microscopic evaluations. (1069222)
1976
32
Migratory glossitis. A clinical-histologic review of seventy cases. (1053669)
1975
33
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. (5270895)
1970
34
Median rhomboid glossitis. Case report. (5353692)
1969
35
Median rhomboid glossitis: an atypical variant. (5234276)
1967
36
Monocytic leukemic glossitis. Report of a case. (5215982)
1966
37
Glossitis. (13417962)
1957
38
Glossitis rhombica mediana: a lesion confused with carcinoma. (14367852)
1955
39
Some aspects of the tongue in pellagrous glossitis. (13061600)
1953
40
Syndrome of anemia, dysphagia and glossitis (Plummer Vinson syndrome). (13111401)
1953
41
A note on tryptophane and pellagrous glossitis. (14861512)
1951
42
A case for diagnosis (syphilitic glossitis?). (20287978)
1947
43
Glossitis and stomatitis due to penicillin lozenges and troches. (21016496)
1946
44
Glossitis rhombica mediana? (21064482)
1946
45
Nodular interstitial glossitis due to syphilis. (21005899)
1945
46
Chronic Superficial Glossitis with Black "Fur". (19986544)
1928
47
Glossitis Migrans. (19984958)
1926
48
Glossitis Migrans; a large unknown Coccus present. (19985451)
1926
49
A CASE OF LATE SYPHILITIC GLOSSITIS TREATED BY SALVARSAN (EHRLICH-HATA). (20766080)
1912
50
Two Cases of Glossitis. (20794069)
1846

Variations for Glossitis

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Expression for genes affiliated with Glossitis

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Search GEO for disease gene expression data for Glossitis.

Pathways for genes affiliated with Glossitis

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Pathways related to Glossitis according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6IL1B, IL6
29.6IL1B, IL6
39.6IL1B, IL6
49.5TNF, IL1B
59.5IL1B, TNF
69.5IL1B, TNF
7
Show member pathways
Serotonin Transporter Activity36
9.5IL1B, TNF
89.5TNF, IL6
99.5IL6, TNF
10
Show member pathways
9.1IL1B, IL6, TNF
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.1TNF, IL6, IL1B
129.1IL1B, IL6, TNF
13
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.1IL1B, IL6, TNF
14
Show member pathways
9.1TNF, IL6, IL1B
15
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1IL1B, IL6, TNF
16
Show member pathways
9.1TNF, IL6, IL1B
17
Show member pathways
9.1TNF, IL6, IL1B
189.1TNF, IL6, IL1B
199.1TNF, IL6, IL1B
209.1IL1B, IL6, TNF
21
Show member pathways
9.1IL1B, IL6, TNF
22
Show member pathways
thioredoxin pathway36
9.1TNF, IL6, IL1B
239.1TNF, IL6, IL1B
24
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.1IL1B, IL6, TNF
259.1TNF, IL6, IL1B
269.1IL1B, IL6, TNF
279.1TNF, IL6, IL1B
28
Show member pathways
IL27-mediated signaling events36
9.1TNF, IL6, IL1B
299.1TNF, IL6, IL1B
30
Show member pathways
9.1TNF, IL6, IL1B
31
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.1IL1B, IL6, TNF
329.1IL1B, IL6, TNF
339.1TNF, IL6, IL1B
349.1TNF, IL6, IL1B
359.1IL1B, IL6, TNF
36
Show member pathways
Immune response MIF in innate immunity response58
9.1IL1B, IL6, TNF
379.1TNF, IL6, IL1B
389.1TNF, IL6, IL1B

Compounds for genes affiliated with Glossitis

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Compounds related to Glossitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1muramyl tripeptide phosphatidylethanolamine4310.0IL6, IL1B
2turpentine439.9IL1B, IL6
3tocilizumab43 1210.8IL6, TNF
4abatacept43 1210.8TNF, IL6
5bucillamine439.7IL6, IL1B
6cdp571439.7IL6, TNF
7tenidap43 2810.5TNF, IL6, IL1B
8anakinra43 1210.5TNF, IL1B, IL6
9vesnarinone439.5IL6, TNF, IL1B
10taurine chloramine439.5IL1B, TNF, IL6
11mip 1alpha439.5IL1B, IL6, TNF
12il-12439.5IL1B, TNF, IL6
13tpck439.5IL6, TNF, IL1B
14polymyxin b439.5IL1B, TNF, IL6
15leflunomide43 49 1211.5TNF, IL1B, IL6
16groalpha439.5TNF, IL6, IL1B
17gm-csf43 2810.5IL1B, IL6, TNF
18triptolide439.5IL1B, IL6, TNF
19ciglitazone43 2810.5IL1B, IL6, TNF
20lipoteichoic acid439.5IL6, TNF, IL1B
21polyinosinic-polycytidylic acid439.5TNF, IL1B, IL6
22etanercept43 49 1211.5IL1B, IL6, TNF
23poly(i-c)439.5IL1B, TNF, IL6
24il 10439.5IL1B, TNF, IL6
25infliximab43 49 1211.5TNF, IL1B, IL6
26peptidoglycan43 2810.5IL6, IL1B, TNF
27ivig439.5IL1B, IL6, TNF
28pentoxifylline43 1210.5IL1B, IL6, TNF
29ccl343 2810.4IL6, TNF, IL1B
3015-deoxy-delta-12,14-prostaglandin j2439.4TNF, IL1B, IL6
31pdtc439.4IL1B, IL6, TNF
32anisomycin43 1210.3IL6, TNF, IL1B
33thalidomide43 49 59 1212.3IL1B, TNF, IL6
34pioglitazone28 43 49 1212.3IL6, TNF, GCG
35leukotriene b443 59 2411.3TNF, IL6, IL1B
36n,n-dimethylsphingosine43 5910.2IL1B, TNF
37sp 60012543 5910.2IL1B, TNF, IL6
38melphalan43 49 1211.2TTR, IL6, TNF
39hydrocortisone43 2 59 1212.2IL6, TNF, IL1B
40troglitazone43 28 59 1212.1IL6, IL1B, TNF
41tgf beta1439.1TNF, IL6, IL1B
42indomethacin43 28 59 1212.0TNF, IL1B, GCG, IL6
43sb 20358043 5910.0TNF, GCG, IL1B, IL6
44neopterin438.9IL6, TTR, TNF, IL1B
45histamine43 28 2410.9IL6, GCG, IL1B, TNF
46pd 98,059438.9GCG, IL1B, TNF, IL6
47ly294002438.9GCG, IL1B, IL6, TNF
48lactate438.6GCG, TNF, TTR, IL6
49cycloheximide438.5GCG, IL6, TNF, IL1B
50genistein43 28 59 2 24 1213.4GCG, IL1B, IL6, TTR, TNF

GO Terms for genes affiliated with Glossitis

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Cellular components related to Glossitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.9TTR, IL6, IL1B, GCG, TNF
2extracellular spaceGO:00056157.6GCG, IL1B, IL6, TTR, TNF

Biological processes related to Glossitis according to GeneCards Suite gene sharing:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1ectoderm developmentGO:000739810.1KRT6B, KRT6A
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.0TNF, IL1B
3sequestering of triglycerideGO:003073010.0TNF, IL1B
4positive regulation of heterotypic cell-cell adhesionGO:00341169.9TNF, IL1B
5positive regulation of fever generationGO:00316229.9TNF, IL1B
6positive regulation of chemokine biosynthetic processGO:00450809.9IL1B, TNF
7regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.9IL1B, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:00510449.9IL1B, TNF
9negative regulation of lipid catabolic processGO:00509959.9TNF, IL1B
10epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.9TNF, IL6
11positive regulation of NF-kappaB import into nucleusGO:00423469.9IL1B, TNF
12negative regulation of lipid storageGO:00108889.9TNF, IL6
13lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL1B, TNF
14positive regulation of mitosisGO:00458409.9TNF, IL1B
15protein kinase B signalingGO:00434919.9IL1B, TNF
16positive regulation of chemokine productionGO:00327229.8IL6, TNF
17negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.8IL1B, TNF
18cellular response to organic cyclic compoundGO:00714079.8TNF, IL1B
19positive regulation of T cell proliferationGO:00421029.8IL1B, IL6
20positive regulation of interferon-gamma productionGO:00327299.8IL1B, TNF
21defense response to Gram-positive bacteriumGO:00508309.8TNF, IL6
22negative regulation of fat cell differentiationGO:00455999.8TNF, IL6
23positive regulation of smooth muscle cell proliferationGO:00486619.7TNF, IL6
24positive regulation of JNK cascadeGO:00463309.7IL1B, TNF
25response to mechanical stimulusGO:00096129.6IL6, TNF
26humoral immune responseGO:00069599.6TNF, IL6
27MAPK cascadeGO:00001659.5IL1B, TNF
28positive regulation of nitric oxide biosynthetic processGO:00454299.5IL1B, IL6, TNF
29positive regulation of interleukin-6 productionGO:00327559.5TNF, IL6, IL1B
30response to glucocorticoidGO:00513849.5IL6, TNF
31positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5TNF, IL6, IL1B
32positive regulation of NF-kappaB transcription factor activityGO:00510929.5TNF, IL6, IL1B
33regulation of insulin secretionGO:00507969.4GCG, IL1B, TNF
34positive regulation of protein kinase B signalingGO:00518979.4IL6, TNF
35positive regulation of peptidyl-serine phosphorylationGO:00331389.4GCG, IL6, TNF
36positive regulation of ERK1 and ERK2 cascadeGO:00703749.4GCG, IL6, TNF
37inflammatory responseGO:00069549.4IL1B, IL6, TNF
38negative regulation of cell proliferationGO:00082859.3TNF, IL6, IL1B
39positive regulation of transcription, DNA-templatedGO:00458938.8TNF, IL6, IL1B

Molecular functions related to Glossitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428028.8GCG, TTR, TNF
2cytokine activityGO:00051258.8IL1B, IL6, TNF

Products for genes affiliated with Glossitis

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Sources for Glossitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet