MCID: GLS007
MIFTS: 46

Glossitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Glossitis

MalaCards integrated aliases for Glossitis:

Name: Glossitis 12 28 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1456
ICD10 32 K14.0
ICD9CM 34 529.0
MeSH 41 D005928
NCIt 46 C112199
UMLS 69 C0017675

Summaries for Glossitis

MalaCards based summary : Glossitis is related to median rhomboid glossitis and tongue disease, and has symptoms including glossalgia An important gene associated with Glossitis is KRT6B (Keratin 6B), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Cefuroxime and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include tongue, lung and monocytes, and related phenotypes are digestive/alimentary and integument

Wikipedia : 72 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

Related Diseases for Glossitis

Diseases related to Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 median rhomboid glossitis 32.5 KRT16 KRT17 KRT6A KRT6B TTR
2 tongue disease 31.9 KRT6A KRT6B
3 fissured tongue 30.3 KRT16 KRT6A
4 burns 30.1 TNF TTR
5 burning mouth syndrome 29.4 IL6 TNF
6 aphthous stomatitis 29.4 IL6 TNF
7 pachyonychia congenita 1 28.8 KRT16 KRT17 KRT6A KRT6B
8 psoriasis 28.8 IL6 KRT16 KRT17 TNF
9 atrophic glossitis 12.2
10 geographic tongue 11.9
11 methylmalonic aciduria and homocystinuria, cblf type 10.9
12 hypertrichosis lanuginosa, acquired 10.9
13 epidermoid cysts 10.3 KRT17 KRT6A
14 chronic pulmonary heart disease 10.2 TNF TTR
15 stomatitis 10.2
16 tinea corporis 10.1 KRT16 KRT17
17 palmoplantar keratoderma, epidermolytic 10.1 KRT16 KRT17
18 steatocystoma multiplex 10.1 KRT16 KRT17
19 bowen's disease 10.1 KRT16 KRT17
20 irritant dermatitis 10.1 KRT16 TNF
21 pustulosis of palm and sole 10.0
22 keratoacanthoma 10.0 KRT16 KRT17
23 aging 10.0
24 primary cutaneous amyloidosis 10.0 KRT16 KRT17
25 scorpion envenomation 10.0 IL6 TNF
26 angioimmunoblastic lymphadenopathy with dysproteinemia 10.0 IL6 TNF
27 critical limb ischemia 10.0 IL6 TNF
28 streptococcal toxic-shock syndrome 10.0 IL6 TNF
29 null-cell leukemia 10.0 IL6 TNF
30 retinitis pigmentosa 55 10.0 IL6 TNF
31 laryngitis 10.0 IL6 TNF
32 anterior uveitis 10.0 IL6 TNF
33 acute vascular insufficiency of intestine 10.0 IL6 TNF
34 posterior urethral valves 10.0 IL6 TNF
35 poems syndrome 10.0 IL6 TNF
36 cheilitis 10.0
37 microscopic colitis 10.0 IL6 TNF
38 meconium aspiration syndrome 10.0 IL6 TNF
39 central nervous system vasculitis 10.0 IL6 TNF
40 osteosclerotic myeloma 10.0 IL6 TNF
41 stachybotrys chartarum 10.0 IL6 TNF
42 louse-borne relapsing fever 10.0 IL6 TNF
43 listeriosis 10.0 IL6 TNF
44 crimean-congo hemorrhagic fever 10.0 IL6 TNF
45 transverse myelitis 10.0 IL6 TNF
46 ischemic heart disease 10.0 IL6 TNF
47 intermediate uveitis 9.9 IL6 TNF
48 monoclonal gammopathy of uncertain significance 9.9 IL6 TNF
49 post-transplant lymphoproliferative disease 9.9 IL6 TNF
50 eales disease 9.9 IL6 TNF

Comorbidity relations with Glossitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Oral Candidiasis

Graphical network of the top 20 diseases related to Glossitis:



Diseases related to Glossitis

Symptoms & Phenotypes for Glossitis

UMLS symptoms related to Glossitis:


glossalgia

MGI Mouse Phenotypes related to Glossitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 IL6 KRT16 KRT17 KRT6B TNF
2 integument MP:0010771 9.02 IL6 KRT16 KRT17 KRT6B TNF

Drugs & Therapeutics for Glossitis

Drugs for Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Antimalarials Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10 cefuroxime axetil Phase 4
11 Antibiotics, Antitubercular Phase 4
12 penicillins Phase 4
13
Hydroxocobalamin Approved 13422-51-0 5460373 44475014 11953898
14
Iron Approved 7439-89-6 23925
15
Ceftriaxone Approved 73384-59-5 5479530 5361919
16
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
17
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
18
leucovorin Approved, Nutraceutical 58-05-9 143 6006
19 Antibodies
20 Autoantibodies
21 Hematinics
22 Immunoglobulins
23 Micronutrients
24 Trace Elements
25 Vitamin B 12
26 Vitamin B Complex
27 Vitamins
28 Antitubercular Agents
29
Cobalamin Nutraceutical 13408-78-1 6438156
30 Folate Nutraceutical
31 Vitamin B12 Nutraceutical
32 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
3 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293
4 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
5 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 doxycycline;doxycycline;placebo
6 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754
7 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
8 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789
9 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249 antibiotic treatment
10 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994 ceftriaxone;doxycycline
11 Analysis of Lyme Disease Lesions Recruiting NCT00132327
12 Erythema Migrans in Elderly Active, not recruiting NCT03371563 Antibiotics

Search NIH Clinical Center for Glossitis

Cochrane evidence based reviews: glossitis

Genetic Tests for Glossitis

Genetic tests related to Glossitis:

# Genetic test Affiliating Genes
1 Glossitis 28

Anatomical Context for Glossitis

MalaCards organs/tissues related to Glossitis:

38
Tongue, Lung, Monocytes, Endothelial, Liver, Colon, Bone

Publications for Glossitis

Articles related to Glossitis:

(show top 50) (show all 223)
# Title Authors Year
1
Benign Migratory Glossitis. ( 29394988 )
2018
2
Benign Migratory Glossitis. ( 29110980 )
2018
3
Isolation of Avipoxvirus from Tongue of Canaries ( Serinus canaria) Show Severe Localized Proliferative Glossitis. ( 29337622 )
2017
4
Host and clinical aspects in patients with benign migratory glossitis. ( 27810384 )
2017
5
Rhomboid glossitis in disseminated CMV infection. ( 28331808 )
2017
6
Mycobacterium abscessus glossitis. ( 28948933 )
2017
7
The Candida species that are important for the development of atrophic glossitis in xerostomia patients. ( 29246167 )
2017
8
Fungal dermatitis, glossitis and disseminated visceral mycosis caused by different Metarhizium granulomatis genotypes in veiled chameleons (Chamaeleo calyptratus) and first isolation in healthy lizards. ( 28757044 )
2017
9
Prevalence and heritability of psoriasis and benign migratory glossitis in one Brazilian population. ( 29364438 )
2017
10
A Rare Case of Glossitis due to Pasteurella multocida after a Cat Scratch. ( 27840749 )
2016
11
Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. ( 27839675 )
2016
12
Rhomboid glossitis caused by candida? ( 27200118 )
2016
13
Nodular granulomatous glossitis as the sole clinical sign in canine leishmaniosis. ( 27755675 )
2016
14
Median rhomboid glossitis-developmental or candidal? ( 26523164 )
2015
15
Waxing and waning eczematous dermatitis andA glossitis. ( 25773429 )
2015
16
Environmental factors in benign migratory glossitis and psoriasis: Retrospective study of the association of emotional stress and alcohol and tobacco consumption with benign migratory glossitis and cutaneous psoriasis. ( 25073550 )
2014
17
Fungiform papillary glossitis. ( 24581085 )
2014
18
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. ( 24966760 )
2014
19
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. ( 24060545 )
2013
20
Matched case-control study to examine association of psoriasis and migratory glossitis in India. ( 23254730 )
2013
21
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. ( 23130817 )
2013
22
Glossitis secondary to vitamin B12 deficiency anemia. ( 23359038 )
2013
23
Diagnostic discussion. Median rhomboid glossitis (MRG). ( 24579425 )
2013
24
Benign migratory glossitis. ( 24413515 )
2013
25
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
26
Clinical pathologic conference case 5: Unusual severe glossitis. ( 23738346 )
2013
27
Benign migratory glossitis with fissured tongue. ( 22918106 )
2012
28
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. ( 22762365 )
2012
29
An apple a day ... chronic glossitis in a 4-year-old boy. ( 22768729 )
2012
30
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. ( 22188475 )
2012
31
A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine. ( 22918478 )
2012
32
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. ( 22737518 )
2011
33
Median rhomboid glossitis. ( 21446620 )
2011
34
The development and inflammatory features of radiotherapy-induced glossitis in rats. ( 21196832 )
2011
35
Taste evaluation in adolescents and pediatric patients with benign migratory glossitis. ( 21802154 )
2011
36
The correlation between the severity of radiotherapy-induced glossitis and endothelial cell injury in local tissues in a rat model. ( 21196860 )
2011
37
Median rhomboid glossitis: a clinical and microbiological study. ( 21912494 )
2011
38
Herpetic geometric glossitis: acyclovir resistant case in a patient with acute myelogenous leukemia. ( 20090244 )
2010
39
Oral pathology. Benign migratory glossitis. ( 20806635 )
2010
40
Predisposition of allergy in patients with benign migratory glossitis. ( 20674406 )
2010
41
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. ( 20339702 )
2010
42
The prevalence and risk factors associated with benign migratory glossitis lesions in 7619 Turkish dental outpatients. ( 19138635 )
2009
43
A classic case of median rhomboid glossitis. ( 19601454 )
2009
44
Herpetic geometric glossitis in an immunocompetent patient with pneumonia. ( 19539852 )
2009
45
Glossitis with linear lesions: an early sign of vitamin B12 deficiency. ( 19231648 )
2009
46
Unusual coexistence of oral lymphoepithelial cyst and benign migratory glossitis. ( 19575124 )
2009
47
Recurrent Trichosporon asahii glossitis: a case report. ( 18335127 )
2008
48
Successful treatment with cyclosporin administration for persistent benign migratory glossitis. ( 17408445 )
2007
49
Images in clinical medicine. Herpetic glossitis. ( 17881747 )
2007
50
Pachyonychia congenita associated with median rhomboid glossitis. ( 17511954 )
2007

Variations for Glossitis

Expression for Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for Glossitis

GO Terms for Glossitis

Cellular components related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.92 KRT16 KRT17 KRT6A KRT6B

Biological processes related to Glossitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytoskeleton organization GO:0007010 9.65 KRT16 KRT6A KRT6B
2 negative regulation of fat cell differentiation GO:0045599 9.51 IL6 TNF
3 positive regulation of interleukin-6 production GO:0032755 9.49 IL6 TNF
4 positive regulation of chemokine production GO:0032722 9.46 IL6 TNF
5 morphogenesis of an epithelium GO:0002009 9.43 KRT16 KRT6A
6 defense response to Gram-positive bacterium GO:0050830 9.43 IL6 KRT6A TNF
7 intermediate filament cytoskeleton organization GO:0045104 9.4 KRT16 KRT6A
8 negative regulation of glucose import GO:0046325 9.37 LMBRD1 TNF
9 negative regulation of lipid storage GO:0010888 9.32 IL6 TNF
10 keratinization GO:0031424 9.26 KRT16 KRT17 KRT6A KRT6B
11 positive regulation of hair follicle development GO:0051798 9.16 KRT17 TNF
12 cornification GO:0070268 8.92 KRT16 KRT17 KRT6A KRT6B

Molecular functions related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 KRT16 KRT17 KRT6A
2 structural constituent of cytoskeleton GO:0005200 8.92 KRT16 KRT17 KRT6A KRT6B

Sources for Glossitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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