MCID: GLS004
MIFTS: 33

Glossopharyngeal Neuralgia malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Glossopharyngeal Neuralgia

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 48NIH Rare Diseases, 49NINDS, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Glossopharyngeal Neuralgia:

Name: Glossopharyngeal Neuralgia 11 48 49 54 13 68
Glossopharyngeal Nerve Diseases 39 68
 
Glossovasopharyngeal Neuralgia 54

Classifications:



External Ids:

Disease Ontology11 DOID:14423
ICD1030 G52.1
ICD9CM32 352.1
MeSH39 D020435
SNOMED-CT62 43763009
Orphanet54 ORPHA221098
UMLS via Orphanet69 C0154731
ICD10 via Orphanet31 G52.1

Summaries for Glossopharyngeal Neuralgia

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NIH Rare Diseases:48 Glossopharyngeal neuralgia is a condition characterized by repeated episodes of severe pain in the tongue, throat, ear, and tonsils (areas connected to the ninth cranial nerve, or glossopharyngeal nerve). it typically occurs in individuals over age 40. episodes of pain may last from a few seconds to a few minutes, and usually occur on one side. the pain may be triggered by swallowing, speaking, laughing, chewing or coughing. the condition is thought to be due to irritation of the nerve, although the source of irritation is unclear. the goal of treatment is to control pain, but over-the-counter pain medications are not very effective; the most effective drugs are anti-seizure medications. some antidepressants help certain people. surgery to cut or take pressure off of the glossopharyngeal nerve may be needed in severe cases. last updated: 1/28/2013

MalaCards based summary: Glossopharyngeal Neuralgia, also known as glossopharyngeal nerve diseases, is related to glossopharyngeal nerve disease and geniculate ganglionitis. An important gene associated with Glossopharyngeal Neuralgia is POMC (Proopiomelanocortin). Affiliated tissues include tongue, tonsil and testes.

NINDS:49 Glossopharyngeal neuralgia (GN) is a rare pain syndrome that affects the glossopharyngeal nerve (the ninth cranial nerve that lies deep within the neck)  and causes sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middle ear.  The excruciating pain of GN can last for a few seconds to a few minutes, and may return multiple times in a day or once every few weeks.  Many individuals with GN relate the attacks of pain to specific trigger factors such as swallowing, drinking cold liquids, sneezing, coughing, talking, clearing the throat, and touching the gums or inside the mouth.  GN can be caused by compression of the glossopharyngeal nerve, but in some cases, no cause is evident.  Like trigeminal neuralgia, it is associated with multiple sclerosis.  GN primarily affects the elderly.

Related Diseases for Glossopharyngeal Neuralgia

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Diseases related to Glossopharyngeal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1glossopharyngeal nerve disease12.1
2geniculate ganglionitis11.1
3syncope10.6
4trigeminal neuralgia10.4
5hemifacial spasm10.3
6syringomelia hyperkeratosis10.2POMC, VIM
7right atrial isomerism10.2CRLF1, KANTR
8thrombocytopenia due to platelet alloimmunization10.2KANTR, POMC
9guillain-barre syndrome10.2KANTR, POMC
10cortical deafness10.2KANTR, POMC
11fungal meningitis10.2CANX, KANTR
12cardiac arrest10.2
13autosomal recessive non-syndromic intellectual disability10.2CRLF1, KANTR
14chronic wasting disease10.2CANX, KANTR
15echolalia10.1NUMA1, POMC
16relapsing fever10.1CRLF1, KANTR
17lethal congenital contracture syndrome 110.1KANTR, VIM
18hepatic angiomyolipoma10.1KANTR, POMC
19craniopharyngioma10.1KANTR, POMC
20pharynx cancer10.1CRLF1, POMC
21periampullary adenoma10.0KANTR, VIM
22hyperpituitarism10.0KANTR, VIM
23astroblastoma10.0KANTR, POMC
24choroiditis10.0
25arachnoiditis10.0
26lipoma9.8
27arteriovenous malformation9.8
28sick sinus syndrome9.8
29squamous cell carcinoma9.8
30pharyngitis9.8
31cervicitis9.8
32cerebritis9.8
33laryngitis9.8
34thyroiditis9.8
35arachnoid cysts9.8
36cluster headache9.8
37headache9.8
38combined hyperactive dysfunction syndrome of the cranial nerves9.8
39vestibular disease8.5BNIP3L, CANX, CRLF1, HNF4A, KANTR, LONP1
40chronic tubotympanic suppurative otitis media8.4BNIP3L, CANX, CRLF1, HNF4A, KANTR, LONP1

Comorbidity relations with Glossopharyngeal Neuralgia via Phenotypic Disease Network (PDN):


Trigeminal Neuralgia

Graphical network of the top 20 diseases related to Glossopharyngeal Neuralgia:



Diseases related to glossopharyngeal neuralgia

Symptoms & Phenotypes for Glossopharyngeal Neuralgia

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Drugs & Therapeutics for Glossopharyngeal Neuralgia

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Drugs for Glossopharyngeal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Pregabalinapproved, illicit, investigationalPhase 2361148553-50-85486971
Synonyms:
(3S)-3-(aminomethyl)-5-methylhexanoic acid
(R-)-3-isobutyl GABA
(S)-3-(Aminomethyl)-5-methylhexanoic acid
(S)-3-Isobutyl gaba
(S+)-3-isobutyl GABA
121GE001
148553-50-8
3-Isobutyl gaba
3-isobutyl GABA
AC-1158
AC1NUP03
AKOS005145504
C080245
C8H17NO2
CHEBI:236161
CHEMBL1059
CI 1008
CI-1008
CID5486971
 
D02716
DB00230
FT-0080911
HSDB 7530
LS-75191
Lyrica
Lyrica (TN)
MolPort-000-861-733
PD 144723
PD-144723
Pregabalin
Pregabalin (JAN/USAN/INN)
Pregabalin [USAN]
Pregablin
S-(+)-3-isobutylgaba
S1731_Selleck
SBB062901
TL8001062
TOS-BB-0910
UNII-55JG375S6M
2Peripheral Nervous System AgentsPhase 223689
3Central Nervous System DepressantsPhase 213403
4AnalgesicsPhase 211733
5Anti-Anxiety AgentsPhase 21885
6Tranquilizing AgentsPhase 24265
7Psychotropic DrugsPhase 26430
8Calcium, DietaryPhase 25713
9AnticonvulsantsPhase 22695
10calcium channel blockersPhase 21985
11
Lidocaineapproved, vet_approved1317137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
12Sodium Channel Blockers1593
13Diuretics, Potassium Sparing1917
14Anesthetics, Local3492
15Anesthetics9596
16Anti-Arrhythmia Agents3093

Interventional clinical trials:

idNameStatusNCT IDPhase
1Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer.RecruitingNCT02924675Phase 2
2Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain.RecruitingNCT02321566Phase 1
3Air Stacking vs Glossopharyngeal Breathing in Neuromuscular DiseasesCompletedNCT02500030
4Glossopharyngeal Nerve Block for Awake IntubationCompletedNCT01790464
5Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated AnomaliesRecruitingNCT03059420

Search NIH Clinical Center for Glossopharyngeal Neuralgia


Cochrane evidence based reviews: glossopharyngeal nerve diseases

Genetic Tests for Glossopharyngeal Neuralgia

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Anatomical Context for Glossopharyngeal Neuralgia

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MalaCards organs/tissues related to Glossopharyngeal Neuralgia:

36
Tongue, Tonsil, Testes, Thyroid, Trigeminal ganglion, Heart

Publications for Glossopharyngeal Neuralgia

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Articles related to Glossopharyngeal Neuralgia:

(show top 50)    (show all 214)
idTitleAuthorsYear
1
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. (26892985)
2016
2
Stereotactic radiosurgery for idiopathic glossopharyngeal neuralgia: an international multicenter study. (27903192)
2016
3
Microvascular decompression for glossopharyngeal neuralgia using intraoperative neurophysiological monitoring: Technical case report. (26862458)
2016
4
Long-term outcomes of percutaneous radiofrequency thermocoagulation for glossopharyngeal neuralgia: A retrospective observational study. (27902620)
2016
5
Microvascular decompression for glossopharyngeal neuralgia through a microasterional approach: A case series. (27213105)
2016
6
Glossopharyngeal neuralgia associated with cardiac syncope. (27102416)
2016
7
Vago-glossopharyngeal neuralgia: a literature review of neurosurgical experience. (25526720)
2015
8
The incidence of high-frequency hearing loss after microvascular decompression for trigeminal neuralgia, glossopharyngeal neuralgia, or geniculate neuralgia. (25932612)
2015
9
Treatment of Glossopharyngeal Neuralgia by Gamma Knife Radiosurgery. (26348903)
2015
10
Conventional and 3-Dimensional Computerized Tomography in Eagle's Syndrome, Glossopharyngeal Neuralgia, and Asymptomatic Controls. (25917666)
2015
11
Glossopharyngeal nerve contrast enhancement in recent-onset glossopharyngeal neuralgia. (25802271)
2015
12
Gamma Knife Radiosurgery for Glossopharyngeal Neuralgia by Targeting the Medial Cisternal Segment of the Glossopharyngeal Nerve: Report of 3 Cases. (26183516)
2015
13
A Perforating Artery Compressing the Nerve Rootlet and Causing Glossopharyngeal Neuralgia. (26103445)
2015
14
Neurosurgical treatment of glossopharyngeal neuralgia: analysis of 103 cases. (26339847)
2015
15
Classification of neurovascular compression in glossopharyngeal neuralgia: Three-dimensional visualization of the glossopharyngeal nerve. (26759734)
2015
16
Case report: Recurrent glossopharyngeal neuralgia after previous glossopharyngeal rhizotomy: Microvascular decompression with intra-operative neurophysiology. (25958960)
2015
17
Glossopharyngeal neuralgia caused by a complex neurovascular conflict: Case report and review of the literature. (25709856)
2015
18
Glossopharyngeal neuralgia associated with cardiac syncope: Two case reports and literature review. (25974354)
2015
19
Glossopharyngeal neuralgia and radiosurgery. (25434956)
2014
20
Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. (24604137)
2014
21
Trigeminal and glossopharyngeal neuralgia. (24703544)
2014
22
Peripheral Facial Palsy and Glossopharyngeal Neuralgia Caused by Malignant Myoepithelioma. (26077185)
2014
23
Intraoperative neurophysiological monitoring of microvascular decompression for glossopharyngeal neuralgia. (25083845)
2014
24
Endovascular Microcatheter Provocation Test for the Diagnosis of Glossopharyngeal Neuralgia. (24435838)
2014
25
Lipoma causing glossopharyngeal neuralgia: a case report and review of literature. (25328654)
2014
26
The treatment of combined trigeminal and glossopharyngeal neuralgia by glycerol rhizolysis of the trigeminal ganglion. (25222621)
2014
27
Treatment Of Glossopharyngeal Neuralgia With Peripheral Glycerol Injection:Our Experience In Twenty One Older Patients. (24102955)
2013
28
Use of electrophysiological monitoring in selective rhizotomy treating glossopharyngeal neuralgia. (24095216)
2013
29
Giant dumbbell-shaped intra- and extracranial nerve schwannoma in a child presenting with glossopharyngeal neuralgia syncope syndrome: a case report and review of the literature. (23104590)
2013
30
Current neurosurgical management of glossopharyngeal neuralgia and technical nuances for microvascular decompression surgery. (23451790)
2013
31
Duration of remission phase of 36 Korean patients with glossopharyngeal neuralgia. (23646244)
2013
32
Effectiveness and safety of Gamma Knife radiosurgery for glossopharyngeal neuralgia. (23814384)
2013
33
Glossopharyngeal neuralgia. (23709235)
2013
34
Glossopharyngeal neuralgia treated with an endoscopic assisted midline suboccipital subtonsillar approach: technical note. (23042141)
2013
35
Peripheral glycerol injection: An alternative treatment of children with glossopharyngeal neuralgia. (24418185)
2013
36
An uncommonly common: Glossopharyngeal neuralgia. (23661955)
2013
37
Analgesic efficacy and safety of medical therapy alone vs combined medical therapy and extraoral glossopharyngeal nerve block in glossopharyngeal neuralgia. (23279193)
2013
38
Non-surgical therapy for bilateral glossopharyngeal neuralgia caused by Eagle's syndrome, diagnosed by three-dimensional computed tomography: a case report. (22760524)
2012
39
Glossopharyngeal neuralgia in the context of a Chiari type I malformation. (22277563)
2012
40
Glossopharyngeal neuralgia as onset of Chiari type I malformation. (22913615)
2012
41
Gamma knife radiosurgery for recurrent glossopharyngeal neuralgia after microvascular decompression. (22678456)
2012
42
Syncopal storm caused by glossopharyngeal neuralgia. (22633719)
2012
43
Glossopharyngeal neuralgia secondary to vascular compression in a patient with multiple sclerosis: a case report. (22812720)
2012
44
Glossopharyngeal neuralgia due to ectatic anterior inferior cerebellar artery. (22954993)
2012
45
Use of endotracheal tube electrodes in treating glossopharyngeal neuralgia: technical note. (22508038)
2012
46
Teaching neuroimages: glossopharyngeal neuralgia with syncope: heart rate and blood pressure change. (21968850)
2011
47
Glossopharyngeal neuralgia: a presentation of 14 cases. (21272973)
2011
48
Glossopharyngeal neuralgia. (21740116)
2011
49
Glossopharyngeal neuralgia caused by arachnoid cyst in the cerebellopontine angle. (21716901)
2011
50
Diagnosis and neurosurgical treatment of glossopharyngeal neuralgia: clinical findings and 3-D visualization of neurovascular compression in 19 consecutive patients. (21567138)
2011

Variations for Glossopharyngeal Neuralgia

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Expression for genes affiliated with Glossopharyngeal Neuralgia

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Search GEO for disease gene expression data for Glossopharyngeal Neuralgia.

Pathways for genes affiliated with Glossopharyngeal Neuralgia

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GO Terms for genes affiliated with Glossopharyngeal Neuralgia

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Sources for Glossopharyngeal Neuralgia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet