MCID: GLS004
MIFTS: 34

Glossopharyngeal Neuralgia

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Glossopharyngeal Neuralgia

MalaCards integrated aliases for Glossopharyngeal Neuralgia:

Name: Glossopharyngeal Neuralgia 12 72 49 50 55 14 69
Glossopharyngeal Nerve Diseases 41 69
Glossovasopharyngeal Neuralgia 55

Classifications:

Orphanet: 55  
Rare neurological diseases


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Disease Ontology 12 DOID:14423
ICD10 32 G52.1
ICD9CM 34 352.1
MeSH 41 D020435
SNOMED-CT 64 43763009
Orphanet 55 ORPHA221098
UMLS via Orphanet 70 C0154731
ICD10 via Orphanet 33 G52.1

Summaries for Glossopharyngeal Neuralgia

NIH Rare Diseases : 49 Glossopharyngeal neuralgia is a disorder that is associated with repeated episodes of severe pain in the tongue, throat, ear, and tonsils. These areas are all connected to the ninth cranial nerve, also called the glossopharyngeal nerve. Episodes of pain may last from a few seconds to a few minutes and usually occur on one side of the face. The pain may be triggered by swallowing, speaking, laughing, chewing, or coughing. Glossopharyngeal neuralgia is thought to be caused by irritation of the glossopharyngeal nerve, but the exact cause of the irritation is sometimes unknown. Laboratory and imaging tests can be used to diagnose the disorder and rule out serious underlying problems. The goal of treatment is to control pain, and the most effective drugs are anti-seizure medications and anti-depressants. Surgery to sever or take pressure off of the glossopharyngeal nerve may be needed in severe cases. Last updated: 11/18/2017

MalaCards based summary : Glossopharyngeal Neuralgia, also known as glossopharyngeal nerve diseases, is related to glossopharyngeal nerve disease and geniculate ganglionitis. An important gene associated with Glossopharyngeal Neuralgia is POMC (Proopiomelanocortin). Affiliated tissues include tongue, tonsil and testes.

NINDS : 50 Glossopharyngeal neuralgia (GN) is a rare pain syndrome that affects the glossopharyngeal nerve (the ninth cranial nerve that lies deep within the neck)  and causes sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middle ear.  The excruciating pain of GN can last for a few seconds to a few minutes, and may return multiple times in a day or once every few weeks.  Many individuals with GN relate the attacks of pain to specific trigger factors such as swallowing, drinking cold liquids, sneezing, coughing, talking, clearing the throat, and touching the gums or inside the mouth.  GN can be caused by compression of the glossopharyngeal nerve, but in some cases, no cause is evident.  Like trigeminal neuralgia, it is associated with multiple sclerosis.  GN primarily affects the elderly.

Wikipedia : 72 Neuralgia (Greek neuron, \"nerve\" + algos, \"pain\") is pain in the distribution of a nerve or nerves,... more...

Related Diseases for Glossopharyngeal Neuralgia

Diseases related to Glossopharyngeal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 glossopharyngeal nerve disease 33.9 CRLF1 SON
2 geniculate ganglionitis 11.2
3 syncope 10.7
4 trigeminal neuralgia 10.5
5 hemifacial spasm 10.4
6 episodic pain syndrome, familial, 1 10.3
7 syndrome of inappropriate antidiuretic hormone 10.3 POMC VIM
8 thyroid crisis 10.3 KANTR POMC
9 laryngeal tuberculosis 10.3 KANTR POMC
10 rh isoimmunization 10.3 NUMA1 POMC
11 cardiac arrest 10.2
12 hyperhidrosis, gustatory 10.2 CANX KANTR
13 neurodermatitis 10.2 KANTR POMC
14 shwartzman phenomenon 10.2 KANTR POMC
15 visual agnosia 10.2 KANTR NUMA1
16 lateral medullary syndrome 10.2 CANX KANTR
17 arachnoiditis 10.1
18 central nervous system origin vertigo 10.1
19 premenstrual tension 10.1 KANTR POMC
20 dystonia 1, torsion, autosomal dominant 10.1 KANTR VIM
21 hemidystonia 10.1 KANTR VIM
22 transient global amnesia 10.0 CRLF1 KANTR
23 multiple sclerosis 10.0
24 choroiditis 10.0
25 testicular leydig cell tumor 10.0 NR5A2 POMC
26 cold-induced sweating syndrome 10.0 CRLF1 KANTR
27 blood group, i system 9.9
28 cardiac arrhythmia 9.9
29 facial spasm 9.9
30 lipomatosis, multiple 9.9
31 spinal arachnoiditis 9.9
32 paine syndrome 9.9
33 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
34 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
35 arteriovenous malformation 9.9
36 sick sinus syndrome 9.9
37 squamous cell carcinoma 9.9
38 pharyngitis 9.9
39 cervicitis 9.9
40 myoepithelioma 9.9
41 cerebritis 9.9
42 laryngitis 9.9
43 thyroiditis 9.9
44 arachnoid cysts 9.9
45 cluster headache 9.9
46 headache 9.9
47 combined hyperactive dysfunction syndrome of the cranial nerves 9.9
48 glomangioma 9.7 KANTR VIM

Comorbidity relations with Glossopharyngeal Neuralgia via Phenotypic Disease Network (PDN):


Trigeminal Neuralgia

Graphical network of the top 20 diseases related to Glossopharyngeal Neuralgia:



Diseases related to Glossopharyngeal Neuralgia

Symptoms & Phenotypes for Glossopharyngeal Neuralgia

Drugs & Therapeutics for Glossopharyngeal Neuralgia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1

Search NIH Clinical Center for Glossopharyngeal Neuralgia

Cochrane evidence based reviews: glossopharyngeal nerve diseases

Genetic Tests for Glossopharyngeal Neuralgia

Anatomical Context for Glossopharyngeal Neuralgia

MalaCards organs/tissues related to Glossopharyngeal Neuralgia:

38
Tongue, Tonsil, Testes, Cortex, Heart, Thyroid, Trigeminal Ganglion

Publications for Glossopharyngeal Neuralgia

Articles related to Glossopharyngeal Neuralgia:

(show top 50) (show all 227)
# Title Authors Year
1
The tethered effect of the arachnoid in vago-glossopharyngeal neuralgia: a real associated alternative mechanism? ( 29075903 )
2018
2
Microvascular decompression for glossopharyngeal neuralgia: a retrospective analysis of 228 cases. ( 29103137 )
2018
3
Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update. ( 28827979 )
2017
4
Microvascular Decompression for Glossopharyngeal Neuralgia: Long-Term Follow-Up. ( 28263933 )
2017
5
Treatments of glossopharyngeal neuralgia: towards standard procedures. ( 28527060 )
2017
6
Microvascular Decompression for Glossopharyngeal Neuralgia: Clinical Analyses of 30 Cases. ( 29142635 )
2017
7
Recurrent syncope due to glossopharyngeal neuralgia. ( 28491772 )
2017
8
Gamma Knife radiosurgery for glossopharyngeal neuralgia: A study of 21 patients with long-term follow-up. ( 28952337 )
2017
9
Microvascular Decompression for a Patient with a Glossopharyngeal Neuralgia: A Technical Note. ( 28948114 )
2017
10
Pregabalin treatment in a pregnant woman with glossopharyngeal neuralgia. ( 28330711 )
2017
11
The emerging role of gamma knife radiosurgery in the management of glossopharyngeal neuralgia. ( 28748271 )
2017
12
Glossopharyngeal neuralgia treated by Gamma Knife radiosurgery: safety and efficacy through long-term follow-up. ( 28621622 )
2017
13
Microvascular decompression for glossopharyngeal neuralgia through a microasterional approach: A case series. ( 27213105 )
2016
14
Long-term outcomes of percutaneous radiofrequency thermocoagulation for glossopharyngeal neuralgia: A retrospective observational study. ( 27902620 )
2016
15
Stereotactic radiosurgery for idiopathic glossopharyngeal neuralgia: an international multicenter study. ( 27903192 )
2016
16
Glossopharyngeal neuralgia associated with cardiac syncope. ( 27102416 )
2016
17
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. ( 26892985 )
2016
18
Microvascular decompression for glossopharyngeal neuralgia using intraoperative neurophysiological monitoring: Technical case report. ( 26862458 )
2016
19
Vago-glossopharyngeal neuralgia: a literature review of neurosurgical experience. ( 25526720 )
2015
20
The incidence of high-frequency hearing loss after microvascular decompression for trigeminal neuralgia, glossopharyngeal neuralgia, or geniculate neuralgia. ( 25932612 )
2015
21
Treatment of Glossopharyngeal Neuralgia by Gamma Knife Radiosurgery. ( 26348903 )
2015
22
Glossopharyngeal neuralgia caused by a complex neurovascular conflict: Case report and review of the literature. ( 25709856 )
2015
23
Case report: Recurrent glossopharyngeal neuralgia after previous glossopharyngeal rhizotomy: Microvascular decompression with intra-operative neurophysiology. ( 25958960 )
2015
24
Neurosurgical treatment of glossopharyngeal neuralgia: analysis of 103 cases. ( 26339847 )
2015
25
Glossopharyngeal nerve contrast enhancement in recent-onset glossopharyngeal neuralgia. ( 25802271 )
2015
26
A Perforating Artery Compressing the Nerve Rootlet and Causing Glossopharyngeal Neuralgia. ( 26103445 )
2015
27
Classification of neurovascular compression in glossopharyngeal neuralgia: Three-dimensional visualization of the glossopharyngeal nerve. ( 26759734 )
2015
28
Conventional and 3-Dimensional Computerized Tomography in Eagle's Syndrome, Glossopharyngeal Neuralgia, and Asymptomatic Controls. ( 25917666 )
2015
29
Gamma Knife Radiosurgery for Glossopharyngeal Neuralgia by Targeting the Medial Cisternal Segment of the Glossopharyngeal Nerve: Report of 3 Cases. ( 26183516 )
2015
30
Glossopharyngeal neuralgia associated with cardiac syncope: Two case reports and literature review. ( 25974354 )
2015
31
Trigeminal and glossopharyngeal neuralgia. ( 24703544 )
2014
32
Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. ( 24604137 )
2014
33
Endovascular Microcatheter Provocation Test for the Diagnosis of Glossopharyngeal Neuralgia. ( 24435838 )
2014
34
The treatment of combined trigeminal and glossopharyngeal neuralgia by glycerol rhizolysis of the trigeminal ganglion. ( 25222621 )
2014
35
Glossopharyngeal neuralgia and radiosurgery. ( 25434956 )
2014
36
Lipoma causing glossopharyngeal neuralgia: a case report and review of literature. ( 25328654 )
2014
37
Peripheral Facial Palsy and Glossopharyngeal Neuralgia Caused by Malignant Myoepithelioma. ( 26077185 )
2014
38
Intraoperative neurophysiological monitoring of microvascular decompression for glossopharyngeal neuralgia. ( 25083845 )
2014
39
Treatment Of Glossopharyngeal Neuralgia With Peripheral Glycerol Injection:Our Experience In Twenty One Older Patients. ( 24102955 )
2013
40
Effectiveness and safety of Gamma Knife radiosurgery for glossopharyngeal neuralgia. ( 23814384 )
2013
41
Glossopharyngeal neuralgia treated with an endoscopic assisted midline suboccipital subtonsillar approach: technical note. ( 23042141 )
2013
42
Current neurosurgical management of glossopharyngeal neuralgia and technical nuances for microvascular decompression surgery. ( 23451790 )
2013
43
Giant dumbbell-shaped intra- and extracranial nerve schwannoma in a child presenting with glossopharyngeal neuralgia syncope syndrome: a case report and review of the literature. ( 23104590 )
2013
44
Use of electrophysiological monitoring in selective rhizotomy treating glossopharyngeal neuralgia. ( 24095216 )
2013
45
Duration of remission phase of 36 Korean patients with glossopharyngeal neuralgia. ( 23646244 )
2013
46
Peripheral glycerol injection: An alternative treatment of children with glossopharyngeal neuralgia. ( 24418185 )
2013
47
Analgesic efficacy and safety of medical therapy alone vs combined medical therapy and extraoral glossopharyngeal nerve block in glossopharyngeal neuralgia. ( 23279193 )
2013
48
Glossopharyngeal neuralgia. ( 23709235 )
2013
49
An uncommonly common: Glossopharyngeal neuralgia. ( 23661955 )
2013
50
Glossopharyngeal neuralgia secondary to vascular compression in a patient with multiple sclerosis: a case report. ( 22812720 )
2012

Variations for Glossopharyngeal Neuralgia

Expression for Glossopharyngeal Neuralgia

Search GEO for disease gene expression data for Glossopharyngeal Neuralgia.

Pathways for Glossopharyngeal Neuralgia

GO Terms for Glossopharyngeal Neuralgia

Biological processes related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular receptor signaling pathway GO:0030522 8.62 HNF4A NR5A2

Molecular functions related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.62 HNF4A NR5A2

Sources for Glossopharyngeal Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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