MCID: GLS004
MIFTS: 33

Glossopharyngeal Neuralgia

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Glossopharyngeal Neuralgia

MalaCards integrated aliases for Glossopharyngeal Neuralgia:

Name: Glossopharyngeal Neuralgia 12 50 51 56 14 69
Glossopharyngeal Nerve Diseases 42 69
Glossovasopharyngeal Neuralgia 56

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:14423
ICD10 33 G52.1
ICD9CM 35 352.1
MeSH 42 D020435
SNOMED-CT 64 43763009
Orphanet 56 ORPHA221098
UMLS via Orphanet 70 C0154731
ICD10 via Orphanet 34 G52.1
UMLS 69 C0154731

Summaries for Glossopharyngeal Neuralgia

NIH Rare Diseases : 50 glossopharyngeal neuralgia is a condition characterized by repeated episodes of severe pain in the tongue, throat, ear, and tonsils (areas connected to the ninth cranial nerve, or glossopharyngeal nerve). it typically occurs in individuals over age 40. episodes of pain may last from a few seconds to a few minutes, and usually occur on one side. the pain may be triggered by swallowing, speaking, laughing, chewing or coughing. the condition is thought to be due to irritation of the nerve, although the source of irritation is unclear. the goal of treatment is to control pain, but over-the-counter pain medications are not very effective; the most effective drugs are anti-seizure medications. some antidepressants help certain people. surgery to cut or take pressure off of the glossopharyngeal nerve may be needed in severe cases. last updated: 1/28/2013

MalaCards based summary : Glossopharyngeal Neuralgia, also known as glossopharyngeal nerve diseases, is related to glossopharyngeal nerve disease and geniculate ganglionitis. An important gene associated with Glossopharyngeal Neuralgia is POMC (Proopiomelanocortin). The drugs Pregabalin and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include tongue, tonsil and cortex.

NINDS : 51 Glossopharyngeal neuralgia (GN) is a rare pain syndrome that affects the glossopharyngeal nerve (the ninth cranial nerve that lies deep within the neck)  and causes sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middle ear.  The excruciating pain of GN can last for a few seconds to a few minutes, and may return multiple times in a day or once every few weeks.  Many individuals with GN relate the attacks of pain to specific trigger factors such as swallowing, drinking cold liquids, sneezing, coughing, talking, clearing the throat, and touching the gums or inside the mouth.  GN can be caused by compression of the glossopharyngeal nerve, but in some cases, no cause is evident.  Like trigeminal neuralgia, it is associated with multiple sclerosis.  GN primarily affects the elderly.

Related Diseases for Glossopharyngeal Neuralgia

Diseases related to Glossopharyngeal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
id Related Disease Score Top Affiliating Genes
1 glossopharyngeal nerve disease 12.1
2 geniculate ganglionitis 11.1
3 syncope 10.6
4 synovial chondromatosis 10.4 POMC VIM
5 trigeminal neuralgia 10.4
6 articulation disorder 10.4 NUMA1 POMC
7 guillain-barre syndrome 10.4 KANTR POMC
8 thrombocytopenia due to platelet alloimmunization 10.3 KANTR POMC
9 hemifacial spasm 10.3
10 angiomyolipoma 10.3 KANTR POMC
11 fungal meningitis 10.3 CANX KANTR
12 craniopharyngioma 10.3 KANTR POMC
13 anterior cerebral artery infarction 10.2 CANX KANTR
14 cardiac arrest 10.2
15 cornea squamous cell carcinoma 10.1 CRLF1 KANTR
16 amyloidosis, finnish type 10.1 KANTR VIM
17 peritoneal benign neoplasm 10.1 CRLF1 KANTR POMC
18 uterine corpus adenocarcinofibroma 10.1 KANTR POMC
19 obstructive sleep apnea 10.0 KANTR VIM
20 arachnoiditis 10.0
21 choroiditis 10.0
22 megalocornea 10.0 CRLF1 KANTR
23 hyperpituitarism 9.9 KANTR VIM
24 sick sinus syndrome 9.8
25 squamous cell carcinoma 9.8
26 pharyngitis 9.8
27 cervicitis 9.8
28 cerebritis 9.8
29 laryngitis 9.8
30 thyroiditis 9.8
31 arachnoid cysts 9.8
32 cluster headache 9.8
33 headache 9.8
34 arteriovenous malformation 9.8
35 combined hyperactive dysfunction syndrome of the cranial nerves 9.8
36 relapsing fever 9.8 CRLF1 KANTR
37 trochlear nerve neoplasm 6.6 BNIP3L CANX CRLF1 KANTR LONP1 MRPL49
38 chronic tubotympanic suppurative otitis media 5.9 BNIP3L CANX CRLF1 HNF4A KANTR LONP1

Comorbidity relations with Glossopharyngeal Neuralgia via Phenotypic Disease Network (PDN):


Trigeminal Neuralgia

Graphical network of the top 20 diseases related to Glossopharyngeal Neuralgia:



Diseases related to Glossopharyngeal Neuralgia

Symptoms & Phenotypes for Glossopharyngeal Neuralgia

Drugs & Therapeutics for Glossopharyngeal Neuralgia

Drugs for Glossopharyngeal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
2 Analgesics Phase 2
3 Anti-Anxiety Agents Phase 2
4 Anticonvulsants Phase 2
5 calcium channel blockers Phase 2
6 Calcium, Dietary Phase 2
7 Central Nervous System Depressants Phase 2
8 Peripheral Nervous System Agents Phase 2
9 Psychotropic Drugs Phase 2
10 Tranquilizing Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer. Recruiting NCT02924675 Phase 2 Pregabalin;Placebo
2 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Recruiting NCT02321566 Phase 1

Search NIH Clinical Center for Glossopharyngeal Neuralgia

Cochrane evidence based reviews: glossopharyngeal nerve diseases

Genetic Tests for Glossopharyngeal Neuralgia

Anatomical Context for Glossopharyngeal Neuralgia

MalaCards organs/tissues related to Glossopharyngeal Neuralgia:

39
Tongue, Tonsil, Cortex, Testes, Heart, Trigeminal Ganglion, Thyroid

Publications for Glossopharyngeal Neuralgia

Articles related to Glossopharyngeal Neuralgia:

(show top 50) (show all 224)
id Title Authors Year
1
Recurrent syncope due to glossopharyngeal neuralgia. ( 28491772 )
2017
2
Gamma Knife radiosurgery for glossopharyngeal neuralgia: A study of 21 patients with long-term follow-up. ( 28952337 )
2017
3
Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update. ( 28827979 )
2017
4
Treatments of glossopharyngeal neuralgia: towards standard procedures. ( 28527060 )
2017
5
Microvascular Decompression for Glossopharyngeal Neuralgia: Long-Term Follow-Up. ( 28263933 )
2017
6
Pregabalin treatment in a pregnant woman with glossopharyngeal neuralgia. ( 28330711 )
2017
7
Microvascular Decompression for a Patient with a Glossopharyngeal Neuralgia: A Technical Note. ( 28948114 )
2017
8
The emerging role of gamma knife radiosurgery in the management of glossopharyngeal neuralgia. ( 28748271 )
2017
9
Glossopharyngeal neuralgia treated by Gamma Knife radiosurgery: safety and efficacy through long-term follow-up. ( 28621622 )
2017
10
Microvascular decompression for glossopharyngeal neuralgia using intraoperative neurophysiological monitoring: Technical case report. ( 26862458 )
2016
11
Stereotactic radiosurgery for idiopathic glossopharyngeal neuralgia: an international multicenter study. ( 27903192 )
2016
12
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. ( 26892985 )
2016
13
Glossopharyngeal neuralgia associated with cardiac syncope. ( 27102416 )
2016
14
Microvascular decompression for glossopharyngeal neuralgia through a microasterional approach: A case series. ( 27213105 )
2016
15
Long-term outcomes of percutaneous radiofrequency thermocoagulation for glossopharyngeal neuralgia: A retrospective observational study. ( 27902620 )
2016
16
Glossopharyngeal neuralgia associated with cardiac syncope: Two case reports and literature review. ( 25974354 )
2015
17
Glossopharyngeal nerve contrast enhancement in recent-onset glossopharyngeal neuralgia. ( 25802271 )
2015
18
Case report: Recurrent glossopharyngeal neuralgia after previous glossopharyngeal rhizotomy: Microvascular decompression with intra-operative neurophysiology. ( 25958960 )
2015
19
A Perforating Artery Compressing the Nerve Rootlet and Causing Glossopharyngeal Neuralgia. ( 26103445 )
2015
20
The incidence of high-frequency hearing loss after microvascular decompression for trigeminal neuralgia, glossopharyngeal neuralgia, or geniculate neuralgia. ( 25932612 )
2015
21
Vago-glossopharyngeal neuralgia: a literature review of neurosurgical experience. ( 25526720 )
2015
22
Neurosurgical treatment of glossopharyngeal neuralgia: analysis of 103 cases. ( 26339847 )
2015
23
Classification of neurovascular compression in glossopharyngeal neuralgia: Three-dimensional visualization of the glossopharyngeal nerve. ( 26759734 )
2015
24
Treatment of Glossopharyngeal Neuralgia by Gamma Knife Radiosurgery. ( 26348903 )
2015
25
Gamma Knife Radiosurgery for Glossopharyngeal Neuralgia by Targeting the Medial Cisternal Segment of the Glossopharyngeal Nerve: Report of 3 Cases. ( 26183516 )
2015
26
Glossopharyngeal neuralgia caused by a complex neurovascular conflict: Case report and review of the literature. ( 25709856 )
2015
27
Conventional and 3-Dimensional Computerized Tomography in Eagle's Syndrome, Glossopharyngeal Neuralgia, and Asymptomatic Controls. ( 25917666 )
2015
28
Lipoma causing glossopharyngeal neuralgia: a case report and review of literature. ( 25328654 )
2014
29
Glossopharyngeal neuralgia and radiosurgery. ( 25434956 )
2014
30
Trigeminal and glossopharyngeal neuralgia. ( 24703544 )
2014
31
Endovascular Microcatheter Provocation Test for the Diagnosis of Glossopharyngeal Neuralgia. ( 24435838 )
2014
32
Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. ( 24604137 )
2014
33
Intraoperative neurophysiological monitoring of microvascular decompression for glossopharyngeal neuralgia. ( 25083845 )
2014
34
Peripheral Facial Palsy and Glossopharyngeal Neuralgia Caused by Malignant Myoepithelioma. ( 26077185 )
2014
35
The treatment of combined trigeminal and glossopharyngeal neuralgia by glycerol rhizolysis of the trigeminal ganglion. ( 25222621 )
2014
36
Glossopharyngeal neuralgia treated with an endoscopic assisted midline suboccipital subtonsillar approach: technical note. ( 23042141 )
2013
37
Glossopharyngeal neuralgia. ( 23709235 )
2013
38
Use of electrophysiological monitoring in selective rhizotomy treating glossopharyngeal neuralgia. ( 24095216 )
2013
39
Giant dumbbell-shaped intra- and extracranial nerve schwannoma in a child presenting with glossopharyngeal neuralgia syncope syndrome: a case report and review of the literature. ( 23104590 )
2013
40
Effectiveness and safety of Gamma Knife radiosurgery for glossopharyngeal neuralgia. ( 23814384 )
2013
41
Peripheral glycerol injection: An alternative treatment of children with glossopharyngeal neuralgia. ( 24418185 )
2013
42
Analgesic efficacy and safety of medical therapy alone vs combined medical therapy and extraoral glossopharyngeal nerve block in glossopharyngeal neuralgia. ( 23279193 )
2013
43
An uncommonly common: Glossopharyngeal neuralgia. ( 23661955 )
2013
44
Current neurosurgical management of glossopharyngeal neuralgia and technical nuances for microvascular decompression surgery. ( 23451790 )
2013
45
Duration of remission phase of 36 Korean patients with glossopharyngeal neuralgia. ( 23646244 )
2013
46
Treatment Of Glossopharyngeal Neuralgia With Peripheral Glycerol Injection:Our Experience In Twenty One Older Patients. ( 24102955 )
2013
47
Glossopharyngeal neuralgia due to ectatic anterior inferior cerebellar artery. ( 22954993 )
2012
48
Non-surgical therapy for bilateral glossopharyngeal neuralgia caused by Eagle's syndrome, diagnosed by three-dimensional computed tomography: a case report. ( 22760524 )
2012
49
Syncopal storm caused by glossopharyngeal neuralgia. ( 22633719 )
2012
50
Gamma knife radiosurgery for recurrent glossopharyngeal neuralgia after microvascular decompression. ( 22678456 )
2012

Variations for Glossopharyngeal Neuralgia

Expression for Glossopharyngeal Neuralgia

Search GEO for disease gene expression data for Glossopharyngeal Neuralgia.

Pathways for Glossopharyngeal Neuralgia

GO Terms for Glossopharyngeal Neuralgia

Biological processes related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 SMAD protein signal transduction GO:0060395 8.62 HNF4A VIM

Sources for Glossopharyngeal Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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