MCID: GLC036
MIFTS: 47

Glucagonoma malady

Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Glucagonoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A glucagonoma is a rare tumor of the alpha cells of the pancreas that results in up to a 1000-fold... more...

MalaCards: Glucagonoma, also known as weight loss, necrolytic migratory erythema , diabetes, stomatitis, and diarrhea, is related to pancreatitis and insulinoma. An important gene associated with Glucagonoma is MADD (MAP-kinase activating death domain), and among its related pathways are G alpha (s) signalling events and Signaling by GPCR. The compounds naltrexone and secretoneurin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and skin, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Glucagonoma

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44NIH Rare Diseases, 46Novoseek, 50Orphanet, 63UMLS, 27ICD10 via Orphanet, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:



Aliases & Descriptions:

glucagonoma 44 46 50 63
weight loss, necrolytic migratory erythema , diabetes, stomatitis, and diarrhea 44
glucagonoma syndrome 44


External Ids:

ICD10 via Orphanet27 E16.8
MESH via Orphanet37 D005935
SNOMED-CT via Orphanet60 128855009, 16424000, 302823005
UMLS via Orphanet64 C0017689

Related Diseases for Glucagonoma

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18GeneCards, 19GeneDecks
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Diseases related to Glucagonoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.0SST, SCT
2insulinoma30.5SCT, SSTR5, SST, GHRH
3gastrinoma30.2SST, SSTR5, SCT
4vipoma30.1SCT, SST, GHRH
5angiodysplasia30.0SST
6somatostatinoma29.9GHRH, SST
7peptic ulcer disease29.9SCT, SST
8adenoma29.9SCT, CHGB, SSTR5, SST, GHRH
9hypoglycemia29.8SCT, SST, GHRH
10prolactinoma29.8SST, SSTR5, CHGB
11pheochromocytoma29.7SCT, CHGB, SSTR5, SST
12hepatitis10.3
13multiple endocrine neoplasia10.3
14dermatitis10.3
15diabetic ketoacidosis10.1
16duodenitis10.1
17primary hyperparathyroidism10.1
18diabetes mellitus10.1
19hyperparathyroidism10.1
20islet cell tumor10.1
21liver disease10.1
22metastatic insulinoma10.1
23somatostatin analog10.1
24dumping syndrome10.1SST
25gigantism10.1SST
26hyperinsulinemic hypoglycemia10.0SST, SCT
27steatorrhea10.0SST, SCT
28atrophic gastritis10.0SCT, SST
29serotonin syndrome10.0GHRH, SST
30duodenal ulcer10.0SCT, SST
31adrenal gland hyperfunction10.0SST, GHRH
32liver cirrhosis10.0GHRH, SCT
33neuroendocrine tumor10.0SST, GHRH
34hyperprolactinemia10.0SST, GHRH
35hypopituitarism10.0SST, GHRH
36cushing's syndrome10.0GHRH, SST
37acute pancreatitis10.0SST, SCT
38hyperthyroidism10.0GHRH, SST
39gastritis10.0SST, SCT
40paraganglioma10.0SST, CHGB
41pancreatitis, chronic10.0SCT, SST
42pancreatic cancer10.0SST, SCT
43acromegaly10.0SSTR5, SST, GHRH
44zollinger-ellison syndrome10.0SCT, SST, GHRH
45wermer syndrome10.0GHRH, SST, SCT
46hyperinsulinism10.0SCT, SST, GHRH
47thyroid medullary carcinoma10.0SST, SSTR5, CHGB
48type 1 diabetes mellitus10.0SCT, SST, GHRH
49hyperglycemia10.0GHRH, SST, SCT
50meningioma9.9SST, SSTR5

Graphical network of the top 20 diseases related to Glucagonoma:



Diseases related to glucagonoma

Symptoms for Glucagonoma

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Drugs & Therapeutics for Glucagonoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Glucagonoma

Drug clinical trials:

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Genetic Tests for Glucagonoma

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Anatomical Context for Glucagonoma

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34MalaCards
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MalaCards organs/tissues related to Glucagonoma:

34
Pancreas, Liver, Skin, Lymph node, Pancreatic islet, Bone, Heart, Ovary, Pituitary

Animal Models for Glucagonoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Glucagonoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5CHGB, SSTR5, SST, GHRH, SCT
2MP:00036317.3MADD, GHRH, SST, CHGB, SCT

Publications for Glucagonoma

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53PubMed
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Articles related to Glucagonoma:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Pancreatic glucagonoma metastasising to the right ovary five years after initial surgery: a case report. (24018597)
2013
2
Pancreatic glucagonoma with pancreatic calcification. (23719610)
2013
3
Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association? (23259638)
2012
4
Bone lesions in recurrent glucagonoma: A case report and review of literature. (22737277)
2012
5
Necrolytic migratory erythema as the first manifestation of glucagonoma. (22970401)
2012
6
An unusual case of subclinical diffuse glucagonoma coexisting with two nodules in the pancreas: characteristic features on computed tomography. (22239827)
2012
7
Glucagonoma syndrome: a case report. (21859461)
2011
8
Necrolytic migratory erythema associated with glucagonoma syndrome. (20530273)
2010
9
Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS). (19525592)
2009
10
Primary malignant hepatic glucagonoma: an autopsy case. (19367016)
2009
11
What is your diagnosis? Necrolytic migratory erythema associated with a glucagonoma. (18306843)
2008
12
Metastatic glucagonoma: treatment with liver transplantation. (16443073)
2006
13
Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome. (16923138)
2006
14
Metastatic insulinoma and glucagonoma from the pancreas responsible for specific peritumoral patterns of hepatic steatosis secondary to local effects of insulin and glucagon on hepatocytes. (16247938)
2005
15
Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus. (12918465)
2003
16
Pancreatic glucagonoma as a rare cause of chronic obstructive pancreatitis. (11023587)
2000
17
Protein metabolism in glucagonoma. (10096785)
1999
18
Cystic glucagonoma with loss of heterozygosity on chromosome 11 in multiple endocrine neoplasia type 1. (9196616)
1997
19
Glucagonoma and pseudoglucagonoma syndromes. (9109001)
1997
20
Glucagonoma: case report and literature review]. (9201330)
1996
21
Rare presentation of endocrine pancreatic tumour: a case of glucagonoma without necrolytic migratory erythema? (8541575)
1995
22
The long-acting somatostatin analogue octreotide alleviates symptoms by reducing posttranslational conversion of prepro-glucagon to glucagon in a patient with malignant glucagonoma, but does not prevent tumor growth. (8186658)
1994
23
An immunohistochemical study of glucagonoma conducted on the metastatic lymph nodes from a patient with recurrent metastatic glucagonoma: report of a case. (7894192)
1994
24
Cystic pancreatic glucagonoma in contact with insulinoma found in a hypoglycemic patient. (1437839)
1992
25
Metastatic glucagonoma: clinical response to a combination of 5-fluorouracil and alpha-interferon. (1524091)
1992
26
Glucagonoma syndrome. (1935216)
1991
27
Necrolytic migratory erythema without glucagonoma: the role of dietary essential fatty acids. (1751353)
1991
28
Protein HMG-17 is hyper-expressed in rat glucagonoma. Single-step isolation and sequencing. (2169420)
1990
29
Electron microscopic and immunoelectron microscopic demonstration of pancreatic polypeptide cells in glucagonoma: colocalization of pancreatic peptide and glucagon in single secretory granules. (2537546)
1989
30
Octreotide (SMS 201-995) in the treatment of metastatic glucagonoma: report of one case and review of the literature. (2548911)
1989
31
Glucagonoma syndrome. Rapid response following arterial embolization of glucagonoma metastatic to the liver. (3030099)
1987
32
Immunocytochemical characterization of 10 pancreatic tumours, associated with the glucagonoma syndrome, using antibodies to separate regions of the pro-glucagon molecule and other neuroendocrine markers. (3007321)
1986
33
Use of a somatostatin analog (SMS 201-995) in the glucagonoma syndrome. (2878500)
1986
34
Secretory response and immunochemical heterogeneity of glucagon in plasma and tumor extracts of a patient with glucagonoma. (3005153)
1986
35
Carbohydrate antigen (CA 19.9) and malignant glucagonoma. (3024003)
1986
36
Disappearance of glucagonoma rash after surgical resection, but not during dietary normalization of serum amino acids. (6320631)
1984
37
Glucagonoma syndrome: case report and literature review. (6092443)
1984
38
Metastatic insulinoma with long survival and glucagonoma syndrome. (6318634)
1984
39
Successful treatment of metastatic glucagonoma with dacarbazine. (6142319)
1984
40
Glucagonoma and its angiographic diagnosis. (6301675)
1982
41
Use of somatostatin and somatostatin analogs in a patient with a glucagonoma. (6114963)
1981
42
A familial glucagonoma syndrome: genetic, clinical and biochemical features. (6112877)
1981
43
Metastatic glucagonoma. improvement after surgical debulking. (6244750)
1980
44
Clinical and metabolic aspects of glucagonoma. (6987481)
1980
45
The glucagonoma syndrome: surgically curable diabetes. (215044)
1979
46
Necrolytic migratory erythema, presenting as candidiasis, due to a pancreatic glucagonoma. (476569)
1979
47
The glucagonoma syndrome and its management. (201809)
1977
48
The glucagonoma syndrome. (195450)
1977
49
Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma. (178682)
1976
50
Glucagonoma syndrome in a young man. (959215)
1976

Variations for Glucagonoma

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Expression for genes affiliated with Glucagonoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glucagonoma

Search GEO for disease gene expression data for Glucagonoma.

Pathways for genes affiliated with Glucagonoma

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Glucagonoma

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46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB
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Compounds related to Glucagonoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1naltrexone46 30 52 1212.8GHRH, SCT
2secretoneurin469.7SCT, CHGB
3dbc-amp469.7GHRH, SCT
4pasireotide46 1210.6SST, SSTR5
5(1r,1s,3r/1r,1r,3s)-l-054,264629.6SSTR5, SST
6cyclosomatostatin629.6SSTR5, SST
7cyn 154806629.6SSTR5, SST
8somatostatin62 2510.6SSTR5, SST
9vapreotide46 30 1211.6SSTR5, SST
10111in-pentetreotide469.6SSTR5, SST
11taurodeoxycholate469.6SST, SCT
12catecholamine469.6CHGB, SCT
13gold469.5GHRH, SCT
14lafutidine469.5SCT, SST
15vinblastine46 52 1211.5SST, MADD
16loxiglumide469.5SCT, SST
17ghrp469.5GHRH, SST
18hexarelin46 3010.5SST, GHRH
19pyridostigmine46 1210.5SST, GHRH
20pegvisomant46 1210.5GHRH, SST
21acipimox46 3010.5GHRH, SST
22pirenzepine46 30 1211.5SST, GHRH
23oxyntomodulin46 6210.5SST, SCT
24omeprazole46 52 30 25 1213.5SST, SCT
25bromocriptine46 30 1211.5SST, GHRH
26naloxone46 30 52 1212.5GHRH, SST
27c-peptide469.4SST, SCT
28levodopa46 1210.4SST, GHRH
29nifedipine46 30 52 1212.2GHRH, SST
30ibmx46 62 3011.1SST, SCT
31lanreotide46 3010.1SSTR5, SST, GHRH
32clonidine46 52 30 1212.0SCT, SST, GHRH
33atropine46 30 1211.0GHRH, SST, SCT
34propranolol46 30 52 25 1213.0SCT, SST, GHRH
35carbachol46 30 1211.0SCT, SST
36thyroxine46 2510.0SCT, SST, GHRH
37adenylate468.9GHRH, SST, SCT
38testosterone46 62 25 1211.9GHRH, SST, SCT
39isoproterenol46 129.8SST, SCT
40arginine468.8SCT, SST, GHRH
41glutamate468.8SCT, SST, GHRH
42dexamethasone46 52 30 1211.7GHRH, SST, CHGB
43glucose468.6GHRH, SST, SCT
44octreotide46 62 30 1211.6SCT, SSTR5, SST, GHRH
45calcium46 52 25 1211.5GHRH, SSTR5, CHGB, SCT
46norepinephrine46 25 1210.4GHRH, SST, CHGB, SCT
47acth468.0GHRH, SST, SSTR5, CHGB, SCT
48dopamine46 30 25 1211.0GHRH, SST, SSTR5, CHGB, SCT

GO Terms for genes affiliated with Glucagonoma

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17Gene Ontology
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Cellular components related to Glucagonoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0GHRH, SST, CHGB, SCT

Biological processes related to Glucagonoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surface receptor signaling pathwayGO:0071669.2MADD, SST

Molecular functions related to Glucagonoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.5SST, CHGB, SCT

Products for genes affiliated with Glucagonoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Glucagonoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet