MCID: GLC037
MIFTS: 38

Glucocorticoid Resistance malady

Reproductive diseases, Endocrine diseases, Fetal diseases categories

Summaries for Glucocorticoid Resistance

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46OMIM, 32MalaCards
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MalaCards: Glucocorticoid Resistance is related to leukemia and asthma. An important gene associated with Glucocorticoid Resistance is NR3C1 (nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)), and among its related pathways are Mineralocorticoid biosynthesis and mTORC1-mediated signalling. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Description from OMIM:46 138040

Aliases & Classifications for Glucocorticoid Resistance

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Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Reproductive diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
glucocorticoid resistance:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Variable


Aliases & Descriptions:

glucocorticoid resistance 42 48 46 60


External Ids:

ICD10 via Orphanet26 E25.8

Related Diseases for Glucocorticoid Resistance

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Glucocorticoid Resistance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0BCL2A1, RPS6KB1, XIAP, CRAT, STAT5A, NR3C1
2asthma30.7RPS6KB1, HSD11B2, STAT5A, NR3C1, MIF, CD28
3myeloma30.4XIAP, STAT5A, NR3C1, CD28, EIF4EBP1, BCL2L11
4arthritis30.3MIF
5rheumatoid arthritis30.3RPS6KB1, HSD11B1, NR3C1, MIF, CD28
6inflammatory bowel disease30.3HSD11B2, HSD11B1, NR3C1, MIF, CD28
7osteosarcoma29.9XIAP, CRAT, NR3C1, BCL2A1
8adenoma29.9HSD11B2, HSD11B1, STAT5A, NR2F2, MIF, BCL2A1
9lung small cell carcinoma29.9RPS6KB1, HSD11B2, NR3C1, GRP
10t-cell leukemia29.9XIAP, CRAT, STAT5A, CD28
11obesity29.9RPS6KB1, HSD11B2, HSD11B1, STAT5A, NR3C1, GRP
12prostate cancer29.9XIAP, CRAT, GRP, MIF
13breast cancer29.9CRAT, XIAP, HSD11B2, RPS6KB1, STAT5A, NR2F2
14acute leukemia10.6
15lymphoblastic leukemia10.6
16childhood leukemia10.4
17ulcerative colitis10.2
18hypertension10.2
19crohn's disease10.1
20systemic lupus erythematosus10.1
21small cell carcinoma10.1
22acute lymphocytic leukemia10.1
23chronic lymphocytic leukemia10.1
24hepatitis10.1
25lupus erythematosus10.1
26multiple myeloma10.1
27nephrotic syndrome10.1
28thrombocytopenia10.1
29acute undifferentiated leukemia10.0SET
30ocular hypertension10.0NR3C1
31colorectal cancer10.0EIF4EBP1, XIAP
32myeloid leukemia10.0CRAT, STAT5A
33pituitary adenoma10.0MIF, NR3C1
34astrocytoma10.0CRAT
35apparent mineralocorticoid excess syndrome10.0HSD11B1, HSD11B2
36choriocarcinoma10.0HSD11B2, CRAT, STAT5A
37cushing's syndrome10.0NR3C1, HSD11B2
38hyperglycemia10.0GRP, HSD11B1, HSD11B2
39endometriosis10.0MIF, NR2F2
40myopathy10.0CRAT
41alzheimer's disease10.0RPS6KB1, XIAP, CRAT, MIF, SET
42hepatocellular carcinoma10.0RPS6KB1, XIAP, CRAT, NR3C1, GRP
43polycystic ovary syndrome10.0HSD11B1
44insulinoma10.0GRP, STAT5A, CRAT
45colon cancer10.0XIAP, GRP, MIF, BCL2L11, BCL2A1
46stomach cancer10.0RPS6KB1, NR3C1, GRP, EIF4EBP1, BCL2L11, BCL2A1
47lung cancer10.0HSD11B2, XIAP, CRAT, GRP, MIF
48hypertrophy of breast10.0EIF4EBP1, GRP, STAT5A, HSD11B1, RPS6KB1
49viral infectious disease10.0XIAP, CRAT, NR3C1, CD28, BCL2L11
50non-small cell lung carcinoma10.0RPS6KB1, XIAP, NR3C1, GRP, MIF, EIF4EBP1

Graphical network of the top 20 diseases related to Glucocorticoid Resistance:



Diseases related to glucocorticoid resistance

Clinical Features for Glucocorticoid Resistance

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Sources:
46OMIM
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Clinical features from OMIM:

138040

Clinical synopsis from OMIM:

138040

Drugs & Therapeutics for Glucocorticoid Resistance

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Glucocorticoid Resistance

Drug clinical trials:

Search ClinicalTrials for Glucocorticoid Resistance

Search NIH Clinical Center for Glucocorticoid Resistance

Search CenterWatch for Glucocorticoid Resistance

Genetic Tests for Glucocorticoid Resistance

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Anatomical Context for Glucocorticoid Resistance

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Animal Models for Glucocorticoid Resistance or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Glucocorticoid Resistance:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.0BCL2L11, HSD11B2, HSD11B1, CRAT, STAT5A, NR2F2
2MP:00053799.9RPS6KB1, XIAP, STAT5A, NR2F2, NR3C1, BCL2L11
3MP:00053979.8HSD11B1, XIAP, STAT5A, NR3C1, MIF, CD28
4MP:00053859.8RPS6KB1, HSD11B2, HSD11B1, XIAP, CRAT, NR2F2
5MP:00053879.7PDE7A, XIAP, HSD11B1, RPS6KB1, STAT5A, NR2F2
6MP:00053849.7CRAT, XIAP, HSD11B1, HSD11B2, RPS6KB1, STAT5A
7MP:00107689.6STAT5A, XIAP, CASP8AP2, HSD11B2, RPS6KB1, NR2F2
8MP:00028739.6HSD11B2, XIAP, STAT5A, NR3C1, FKBP5, MIF

Publications for Glucocorticoid Resistance

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Genetic Variations for Glucocorticoid Resistance

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Expression for genes affiliated with Glucocorticoid Resistance

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glucocorticoid Resistance

Search GEO for disease gene expression data for Glucocorticoid Resistance.

Pathways for genes affiliated with Glucocorticoid Resistance

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Sources:
53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 29KEGG, 51QIAGEN, 49PharmGKB
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Pathways related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3HSD11B1, HSD11B2
2
Hide members
10.3EIF4EBP1, RPS6KB1
310.3SET, NUP214
4
Hide members
10.3BCL2A1, BCL2L11, XIAP
510.3STAT5A, NR3C1, FKBP5
610.2RPS6KB1, EIF4EBP1, BCL2L11
7
Hide members
10.2RPS6KB1, EIF4EBP1, BCL2L11
8
Apoptosis and survival Caspase cascade
Hide members
10.2CASP8AP2, XIAP, BCL2L11
9
Hide members
10.2EIF4EBP1, STAT5A, RPS6KB1
10
Hide members
10.2RPS6KB1, STAT5A, EIF4EBP1
11
Development Prolactin receptor signaling
Hide members
10.2RPS6KB1, STAT5A, NR3C1, EIF4EBP1
12
Hide members
10.1BCL2L11, EIF4EBP1, STAT5A, RPS6KB1
1310.1RPS6KB1, STAT5A, EIF4EBP1, BCL2L11

Compounds for genes affiliated with Glucocorticoid Resistance

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8FKBP5
2estrogen4410.8NR2F2, HSD11B1
3cortisone acetate44 1111.7HSD11B2, HSD11B1, NR3C1
411-dehydrocorticosterone44 2411.7HSD11B1, NR3C1, HSD11B2
5glucose4410.7XIAP, EIF4EBP1
6cortisol28 2411.7NR3C1, HSD11B1, HSD11B2
7estradiol44 11 2412.7RPS6KB1, XIAP, CRAT
8glycyrrhetinic acid44 2411.7NR3C1, HSD11B2, HSD11B1
9molybdate4410.6FKBP5, NR3C1, BCL2A1
10serine4410.6SET, MIF, EIF4EBP1, BCL2A1
11glycyrrhizin44 2811.6HSD11B1, HSD11B2, NR3C1
12dexamethasone sodium phosphate4410.6BCL2A1, NR3C1
13cortisone44 2411.6NR3C1, HSD11B1, HSD11B2
14mifepristone44 59 28 1113.6HSD11B2, HSD11B1, NR3C1, FKBP5, BCL2A1
15butyrate4410.6CRAT, NR3C1, HSD11B2
16carbenoxolone28 44 1112.5HSD11B2, HSD11B1, NR3C1
17tacrolimus44 49 1112.5RPS6KB1, FKBP5, NR3C1, BCL2A1, CD28
18corticosterone44 59 2412.5HSD11B2, NR3C1, HSD11B1, GRP, BCL2A1, MIF
19acth4410.5HSD11B1, NR3C1, GRP, MIF, BCL2A1, HSD11B2
20hydrocortisone44 2 59 1113.4HSD11B2, MIF, HSD11B1, STAT5A, NR3C1, GRP
21sb 20358044 5911.4NR3C1, STAT5A, RPS6KB1, BCL2L11, MIF
22paclitaxel44 49 1112.4EIF4EBP1, MIF, CRAT, XIAP, RPS6KB1, BCL2L11
23etoposide44 49 59 1113.4BCL2L11, NR3C1, STAT5A, CRAT, XIAP, GRP
24progesterone44 59 28 11 2414.3HSD11B2, HSD11B1, CRAT, STAT5A, NR2F2, NR3C1
25ly2940024410.3STAT5A, XIAP, RPS6KB1, CD28, EIF4EBP1, BCL2L11
26norepinephrine44 11 2412.3CRAT, HSD11B2, BCL2A1, MIF, GRP
27cisplatin44 49 59 1113.3CRAT, XIAP, RPS6KB1, GRP, NR3C1, EIF4EBP1
28actinomycin d4410.3NR3C1, BCL2L11, RPS6KB1, HSD11B2, GRP, EIF4EBP1
29ibmx44 28 5912.3PDE7A, CRAT, STAT5A, GRP
30dexamethasone44 49 28 1113.3FKBP5, BCL2A1, HSD11B2, GRP, NR3C1, XIAP
31steroid4410.3FKBP5, NR3C1, BCL2A1, MIF, NR2F2, STAT5A
32pd 98,0594410.3BCL2L11, EIF4EBP1, XIAP, STAT5A, RPS6KB1
33allotetrahydrocortisol4410.2HSD11B2, HSD11B1
34mg 13244 5911.2STAT5A, NR3C1, BCL2L11, XIAP
35oligonucleotide4410.2XIAP, PDE7A, BCL2L11, CD28, RPS6KB1, STAT5A
36h2o24410.2MIF, CRAT, EIF4EBP1, XIAP, RPS6KB1, BCL2L11
37vegf4410.2EIF4EBP1, RPS6KB1, XIAP, CRAT, STAT5A, GRP
38cyclic amp44 2411.2RPS6KB1, CRAT, STAT5A, GRP, PDE7A, CD28
39phosphatidylinositol4410.2EIF4EBP1, XIAP, GRP, CD28, BCL2L11, STAT5A
40rapamycin4410.2NR3C1, GRP, BCL2L11, FKBP5, STAT5A, XIAP
41wortmannin4410.2CD28, GRP, EIF4EBP1, STAT5A, RPS6KB1
42retinoic acid44 2411.2EIF4EBP1, CRAT, XIAP, RPS6KB1, STAT5A, NR2F2
43oxygen44 2411.1BCL2L11, STAT5A, CRAT, XIAP, HSD11B2, RPS6KB1
44testosterone44 59 11 2413.1FKBP5, HSD11B1, CRAT, NR3C1, GRP, BCL2A1
45lipid4410.1RPS6KB1, HSD11B2, HSD11B1, XIAP, NR2F2, EIF4EBP1
46doxorubicin44 49 1112.1XIAP, CRAT, NR3C1, GRP, MIF
47phosphoinositide4410.0CD28, RPS6KB1, EIF4EBP1, BCL2L11, GRP
48tyrosine4410.0MIF, RPS6KB1, XIAP, STAT5A, HSD11B1, NR2F2
4911beta-hydroxysteroid4410.0NR3C1, HSD11B1, HSD11B2
50calcium44 49 11 2413.0RPS6KB1, MIF, CD28, SET, BCL2A1, XIAP

GO Terms for genes affiliated with Glucocorticoid Resistance

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16Gene Ontology
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Cellular components related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.6BCL2L11, XIAP, PDE7A, STAT5A, NR3C1, NUP214

Biological processes related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:00670410.4HSD11B1, HSD11B2
2positive regulation of mitotic cell cycleGO:04593110.3EIF4EBP1, STAT5A, RPS6KB1
3TOR signaling cascadeGO:03192910.2EIF4EBP1, RPS6KB1
4apoptotic signaling pathwayGO:09719010.2BCL2L11, CD28, CASP8AP2
5signal transductionGO:00716510.0RPS6KB1, CASP8AP2, PDE7A, NR2F2, NR3C1, GRP
6positive regulation of interleukin-2 biosynthetic processGO:04508610.0STAT5A, CD28

Molecular functions related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
111-beta-hydroxysteroid dehydrogenase [NAD(P)] activityGO:00384510.0HSD11B1, HSD11B2
2protein bindingGO:0055159.4CASP8AP2, XIAP, STAT5A, NR2F2, NR3C1, MIF

Products for genes affiliated with Glucocorticoid Resistance

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glucocorticoid Resistance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet