MCID: GLC037
MIFTS: 46

Glucocorticoid Resistance malady

Rare diseases, Reproductive diseases, Endocrine diseases, Fetal diseases categories
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Summaries for Glucocorticoid Resistance

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47OMIM, 33MalaCards
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MalaCards: Glucocorticoid Resistance is related to myeloma and breast cancer. An important gene associated with Glucocorticoid Resistance is NR3C1 (nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)), and among its related pathways are Glucocorticoid receptor regulatory network and Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins. The compounds dexamethasone sodium phosphate and mirtazapine have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and testes, and related mouse phenotypes are renal/urinary system and normal.

Description from OMIM:47 138040

Aliases & Classifications for Glucocorticoid Resistance

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43NIH Rare Diseases, 49Orphanet, 47OMIM, 62UMLS, 26ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
glucocorticoid resistance:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Variable


Aliases & Descriptions:

glucocorticoid resistance 43 49 47 62


External Ids:

ICD10 via Orphanet26 E25.8

Related Diseases for Glucocorticoid Resistance

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Glucocorticoid Resistance:



Diseases related to glucocorticoid resistance

Symptoms for Glucocorticoid Resistance

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47OMIM
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Symptoms by clinical synopsis from OMIM:

138040

Clinical features from OMIM:

138040

Drugs & Therapeutics for Glucocorticoid Resistance

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Glucocorticoid Resistance

Search NIH Clinical Center for Glucocorticoid Resistance

Genetic Tests for Glucocorticoid Resistance

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Anatomical Context for Glucocorticoid Resistance

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33MalaCards
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MalaCards organs/tissues related to Glucocorticoid Resistance:

33
T cells, Skin, Testes, Smooth muscle, Prostate, Breast, Thymus, Lung, Kidney, Spleen, Brain, Pituitary

Animal Models for Glucocorticoid Resistance or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Glucocorticoid Resistance:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5HSD11B2, FKBP5, BCL2L11, NR3C1
2MP:00028738.3NR3C1, BCL2L11, FKBP5, HSD11B2
3MP:00030128.2NR2F2, NR3C1, BCL2L11, HSD11B2
4MP:00053858.1NR2F2, NR3C1, BCL2L11, HSD11B2
5MP:00053897.9FKBP5, BCL2L11, NR3C1, NR2F2
6MP:00053767.6HSD11B2, FKBP5, BCL2L11, NR3C1, NR2F2
7MP:00107687.3NR2F2, NR3C1, BCL2L11, BCL2A1, FKBP5, HSD11B2

Publications for Glucocorticoid Resistance

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52PubMed
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Articles related to Glucocorticoid Resistance:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Rapamycin sensitizes glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells to dexamethasone induced apoptosis through both mTOR suppression and up-regulation and activation of glucocorticoid receptor. (23611130)
2013
2
Inflammatory cellular phenotypes and molecular mechanisms of glucocorticoid resistance in patients with bronchial asthma. (23597084)
2013
3
Role of human papillomaviruses in persistent and glucocorticoid-resistant juvenile phimosis. (22471970)
2013
4
Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia. (22282267)
2012
5
Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia. (22050419)
2012
6
Generalized glucocorticoid resistance accompanied with an adrenocortical adenoma and caused by a novel point mutation of human glucocorticoid receptor gene. (21362280)
2011
7
Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. (21527497)
2011
8
Super-high-dose methylprednisolone does not improve efficacy or induce glucocorticoid resistance in experimental allergic encephalomyelitis. (20616573)
2011
9
The zebrafish as an in vivo model system for glucocorticoid resistance. (20493895)
2010
10
Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance. (20810926)
2010
11
Heterogeneity of glucocorticoid resistance in patients with bronchial asthma. (23675190)
2010
12
Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells. (19737543)
2010
13
Glucocorticoid resistance in inflammatory diseases. (19482216)
2009
14
Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen. (18037570)
2008
15
Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G1 cell cycle arrest and apoptosis. (18685609)
2008
16
Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Ibeta and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiated leukemia with Set-Can translocation. (18096310)
2008
17
Primary glucocorticoid resistance syndrome presenting as pseudo-precocious puberty and galactorrhea]. (19024330)
2008
18
Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia. (17483364)
2007
19
A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance. (17635946)
2007
20
Glucocorticoid resistance. (17125454)
2006
21
Unsupervised proteome analysis of human leukaemia cells identifies the Valosin-containing protein as a putative marker for glucocorticoid resistance. (16541142)
2006
22
The physiology of human glucocorticoid receptor beta (hGRbeta) and glucocorticoid resistance. (16855130)
2006
23
Genetic variations in the glucocorticoid receptor gene are not related to glucocorticoid resistance in childhood acute lymphoblastic leukemia. (16115950)
2005
24
Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype. (15070967)
2004
25
Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. (15243581)
2004
26
Molecular mechanisms of glucocorticoid resistance in splenocytes of socially stressed male mice. (12667647)
2003
27
Cell- and tIssue-specific effects of corticosteroids in relation to glucocorticoid resistance: examples from the brain. (12844331)
2003
28
Glucocorticoid resistance in childhood leukaemia: mechanisms and modulation. (12648060)
2003
29
Interleukin-6 and the development of social disruption-induced glucocorticoid resistance. (11958817)
2002
30
Increased urinary cortisol and androgen metabolites in a young female with hypertension: partial glucocorticoid resistance syndrome. (10894920)
2000
31
Glucocorticoid resistance in premature pubarche and adolescent hyperandrogenism. (10068517)
1999
32
Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia. (9920778)
1999
33
Glucocorticoid resistance caused by reduced expression of the glucocorticoid receptor in cells from human vascular lesions. (10323768)
1999
34
Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice. (9462512)
1998
35
Antiprogestins and iatrogenic glucocorticoid resistance. (9048964)
1997
36
Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance. (9150737)
1997
37
Mechanisms of glucocorticoid resistance in human leukemic cells: implication of abnormal 90 and 70 kDa heat shock proteins. (8667658)
1996
38
Glucocorticoid receptor structure and function in glucocorticoid-resistant small cell lung carcinoma cells. (8764121)
1996
39
Glucocorticoid resistance in humans. (18406688)
1995
40
Glucocorticoid resistance. (7704706)
1994
41
Frequency of glucocorticoid resistance and dependency in Crohn's disease. (8150347)
1994
42
Hormone-nuclear receptor interactions in health and disease. Glucocorticoid resistance. (7980839)
1994
43
Dexamethasone therapy for isosexual precocious pseudopuberty caused by generalized glucocorticoid resistance. (7989467)
1994
44
Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance. (8319583)
1993
45
Regulation of glucocorticoid receptor expression in cultured fibroblasts from a patient with familial glucocorticoid resistance. (1659867)
1991
46
Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. (1952426)
1991
47
Glucocorticoid receptors and glucocorticoid resistance in human leukemia in vivo and in vitro. (3521219)
1986
48
Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone. (6333828)
1984
49
Role of de novo DNA methylation in the glucocorticoid resistance of a T-lymphoid cell line. (6601244)
1983
50
Concanavalin A-induced glucocorticoid resistance in rat thymus cells: decreased cytoplasmic and nuclear receptor binding of dexamethasone. (1025360)
1976

Variations for Glucocorticoid Resistance

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Expression for genes affiliated with Glucocorticoid Resistance

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glucocorticoid Resistance

Search GEO for disease gene expression data for Glucocorticoid Resistance.

Pathways for genes affiliated with Glucocorticoid Resistance

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome
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Pathways related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6NR3C1, FKBP5
2
Show member pathways
9.5BCL2L11, BCL2A1
3
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.5BCL2L11, BCL2A1
4
Show member pathways
Nuclear Receptors38
9.3NR2F2, NR3C1

Compounds for genes affiliated with Glucocorticoid Resistance

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1dexamethasone sodium phosphate4510.0BCL2A1, NR3C1
2mirtazapine45 51 1111.9FKBP5, NR3C1
3cortisone acetate45 1110.9NR3C1, HSD11B2
411-dehydrocorticosterone45 2410.9NR3C1, HSD11B2
5cortisol29 2410.8NR3C1, HSD11B2
6doca459.8HSD11B2, NR3C1
7glycyrrhetinic acid45 2410.8HSD11B2, NR3C1
8glycyrrhizin45 2910.8NR3C1, HSD11B2
9betamethasone45 1110.8NR3C1, HSD11B2
10cortisone45 2410.8NR3C1, HSD11B2
11carbenoxolone45 29 1111.8NR3C1, HSD11B2
12spironolactone45 61 29 51 1113.8HSD11B2, NR3C1
13budesonide45 51 1111.7NR3C1, HSD11B2
14fluticasone propionate45 51 61 1112.7NR3C1, HSD11B2
1511beta-hydroxysteroid459.7HSD11B2, NR3C1
16progestin459.7FKBP5, NR3C1
17dhea459.7NR3C1, HSD11B2
18mg 13245 6110.6NR3C1, BCL2L11
19molybdate459.5NR3C1, BCL2A1, FKBP5
20prednisolone45 29 1111.5NR3C1, HSD11B2
21tacrolimus45 51 1111.5NR3C1, BCL2A1, FKBP5
22corticosterone45 61 2411.4HSD11B2, BCL2A1, NR3C1
23hydrocortisone45 3 61 1112.4HSD11B2, NR3C1
24acth459.4HSD11B2, BCL2A1, NR3C1
25rapamycin459.3NR3C1, BCL2L11, FKBP5
26cycloheximide459.2FKBP5, BCL2L11, NR3C1
27actinomycin d459.2HSD11B2, BCL2L11, NR3C1
28testosterone45 61 24 1112.2NR3C1, BCL2A1, FKBP5
29dihydrotestosterone45 29 24 1112.2NR3C1, HSD11B2
30mifepristone45 29 61 1111.9NR3C1, BCL2A1, FKBP5, HSD11B2
31serine458.6NR3C1, BCL2L11, BCL2A1, HSD11B2
32dexamethasone45 51 29 1111.4NR3C1, BCL2L11, BCL2A1, FKBP5, HSD11B2
33progesterone45 29 61 24 1112.1HSD11B2, FKBP5, BCL2A1, NR3C1, NR2F2
34steroid458.1HSD11B2, FKBP5, BCL2A1, NR3C1, NR2F2
35estrogen458.1HSD11B2, BCL2A1, BCL2L11, NR3C1, NR2F2

GO Terms for genes affiliated with Glucocorticoid Resistance

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16Gene Ontology
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Cellular components related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.5BCL2L11, BCL2A1

Biological processes related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.5BCL2L11, BCL2A1
2extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4BCL2L11, BCL2A1
3positive regulation of neuron apoptotic processGO:0435259.3NR3C1, BCL2L11

Molecular functions related to Glucocorticoid Resistance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.5NR3C1, HSD11B2

Products for genes affiliated with Glucocorticoid Resistance

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Sources for Glucocorticoid Resistance

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet