MCID: GLC003
MIFTS: 62

Glucose Intolerance malady

Gastrointestinal category

Summaries for Glucose Intolerance

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Your small intestine does most of the digesting of the foods you eat. if you have a malabsorption syndrome, your small intestine cannot absorb nutrients from foods. causes of malabsorption syndromes include celiac disease lactose intolerance short bowel syndrome. this happens after surgery to remove half or more of the small intestine. you might need the surgery if you have a problem with the small intestine from a disease, injury, or birth defect. whipple disease, a rare bacterial infection genetic diseases certain medicines symptoms of different malabsorption syndromes can vary. they often include chronic diarrhea, abnormal stools, weight loss, and gas. your doctor may use lab, imaging, or other tests to make a diagnosis. treatment of malabsorption syndromes depends on the cause.

MalaCards: Glucose Intolerance, also known as malabsorption, is related to insulin resistance and polycystic ovary syndrome. An important gene associated with Glucose Intolerance is SERPINA6 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6), and among its related pathways are Glucose / Energy Metabolism and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drug glucomannan and the compounds lipid and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Wikipedia:64 Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with... more...

Aliases & Classifications for Glucose Intolerance

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

glucose intolerance 8 10 45
malabsorption 8 45
impaired glucose tolerance 61
malabsorption of glucose 8
malabsorption syndromes 34
malabsorption syndrome 61
glucose: intolerance 8


External Ids:

Disease Ontology8 DOID:10603
MeSH35 D018149
ICD1025 K90.4

Related Diseases for Glucose Intolerance

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Glucose Intolerance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 429)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.4IGFBP1, PCK2, RETN, INS, SLC2A4, PAX4
2polycystic ovary syndrome30.9CAPN10, SHBG, IGFBP1, INS
3gestational diabetes30.9LSL, RBP4, SHBG, IGFBP1, RETN, INS
4cystic fibrosis30.7INS, RBP4, CAPN10
5atherosclerosis30.5SHBG, LIPE, RETN, INS, ENPP1, ADIPOQ
6acute myocardial infarction30.5RETN, IGFBP1, TXN
7hepatitis c30.5TXN, LSL, ADIPOQ
8type 1 diabetes30.4RBP4, IGFBP1, RETN, INS, PAX4, ENPP1
9hypertriglyceridemia30.4ADRB3, ADIPOQ, SLC2A4, INS, SHBG, LSL
10acromegaly30.4LSL, SHBG, IGFBP1, RETN, INS, ADIPOQ
11coronary heart disease30.3SHBG, LIPE, RETN, INS, ADIPOQ, ADRB3
12coronary artery disease,30.3TXN, IGFBP1, RETN, INS, ENPP1, ADIPOQ
13fatty liver disease30.3INS, RETN, RBP4
14hypercholesterolemia30.3CAPN10, PDX1, RBP4, RETN, INS, ADIPOQ
15alzheimer's disease30.3TXN, RBP4, SHBG, INS
16type 2 diabetes mellitus30.2GCK, CAPN10, LSL, PDX1, RBP4, SHBG
17acanthosis nigricans30.2ADIPOQ, INS, SHBG
18sepsis30.2TXN, LSL, RBP4, RETN, SLC2A4, SERPINA6
19adenocarcinoma30.2PDX1, IGFBP1, SLC2A4
20prediabetes syndrome30.2INS, ADIPOQ
21hypoglycemia30.0GCK, LSL, GYS1, IGFBP1, PCK2, INS
22hyperandrogenism30.0CAPN10, LSL, SHBG, IGFBP1, RETN, INS
23hyperinsulinism30.0GCK, LSL, SHBG, IGFBP1, RETN, INS
24infertility30.0CAPN10, LSL, SHBG, IGFBP1, RETN, INS
25insulinoma30.0GCK, PDX1, INS, PAX4
26arthritis30.0TXN, RETN, ADIPOQ
27anovulation30.0SHBG, IGFBP1, INS
28hyperinsulinemic hypoglycemia30.0GCK, INS
29graves' disease30.0SHBG
30colorectal cancer30.0PAX6, TXN
31hyperprolactinemia30.0SHBG
32tuberculosis30.0LIPE, LSL
33adenoma30.0SHBG, IGFBP1, INS
34marasmus30.0LSL
35blindness29.9INS
36primary hyperoxaluria29.6CAPN10, LSL, RBP4, RETN, INS, ENPP1
37hereditary folate malabsorption10.5
38autonomic dysfunction10.4
39tropical sprue10.4
40lactose intolerance10.4
41n syndrome10.3
42steatorrhea10.3
43autonomic neuropathy10.3
44diabetes, type 210.3
45pernicious anemia10.3
46young syndrome10.3
47carotid intimal medial thickness10.3
48blind loop syndrome10.3
49exocrine pancreatic insufficiency10.2
50giardiasis10.2

Graphical network of the top 20 diseases related to Glucose Intolerance:



Diseases related to glucose intolerance

Clinical Features for Glucose Intolerance

Drugs & Therapeutics for Glucose Intolerance

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Glucose Intolerance

Drug clinical trials:

Search ClinicalTrials for Glucose Intolerance

Search NIH Clinical Center for Glucose Intolerance

Search CenterWatch for Glucose Intolerance

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Glucose Intolerance

Anatomical Context for Glucose Intolerance

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Glucose Intolerance:

33
Bone marrow, Brain, Heart, Skeletal muscle, Small intestine, Adipocyte, Kidney, Liver, Pancreas, Thyroid, Breast, Ovary, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Hypothalamus, Fetal liver, Fetal thyroid, Pancreatic islet, Pituitary

Animal Models for Glucose Intolerance or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Glucose Intolerance

Sources:
51PubMed
See all sources

Articles related to Glucose Intolerance:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
The impact of nutrition and glucose intolerance on the development of tuberculosis in Japan. (24365558)
2014
2
Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats. (23793169)
2013
3
Testosterone promotes glucose intolerance, lipid disorder and oxidative stress in type 1 diabetic rats. (23729563)
2013
4
Endothelial function in women with and without a history of glucose intolerance in pregnancy. (23819127)
2013
5
Erythropoietin inhibits gluconeogenesis and inflammation in the liver and improves glucose intolerance in high-fat diet-fed mice. (23326455)
2013
6
High-density lipoprotein: a new therapeutic target for glucose intolerance? (24170387)
2013
7
Orexin-A suppresses postischemic glucose intolerance and neuronal damage through hypothalamic brain-derived neurotrophic factor. (23117790)
2013
8
Effects of pravastatin and atorvastatin on HDL cholesterol and glucose metabolism in patients with dyslipidemia and glucose intolerance: the PRAT study. (23257975)
2013
9
An iTRAQ proteomic study reveals an association between diet-induced enhanced fatty acid metabolism and the development of glucose intolerance in prediabetic mice. (23316967)
2013
10
Marked decline in beta cell function during pregnancy leads to the development of glucose intolerance in Japanese women. (23292170)
2013
11
Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance. (23287371)
2013
12
Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with I^-hydroxy-I^-methylbutyrate in rats. (24053521)
2013
13
Effect of maternal weight, adipokines, glucose intolerance and lipids on infant birth weight among women without gestational diabetes mellitus. (22619341)
2012
14
Male mice produced by in vitro culture have reduced fertility and transmit organomegaly and glucose intolerance to their male offspring. (22649070)
2012
15
Slow-release insulin in cystic fibrosis patients with glucose intolerance: a randomized clinical trial. (22060105)
2012
16
Comparison between valsartan and amlodipine regarding cardiovascular morbidity and mortality in hypertensive patients with glucose intolerance: NAGOYA HEART Study. (22232134)
2012
17
Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice. (22038518)
2012
18
Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females. (23028811)
2012
19
High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study. (22716959)
2012
20
Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. (22745735)
2012
21
A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. (21751816)
2011
22
Sox9-haploinsufficiency causes glucose intolerance in mice. (21829703)
2011
23
Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance. (21940780)
2011
24
Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians. (21399856)
2011
25
The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy. (20855478)
2010
26
Development of glucose intolerance in Wistar rats fed low and moderate fat diets differing in fatty acid profile. (20186659)
2010
27
Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes. (20228173)
2010
28
Pakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in the Punjab Province of Pakistan. (20149776)
2010
29
Free-living physical activity energy expenditure is strongly related to glucose intolerance in Cameroonian adults independently of obesity. (19017776)
2009
30
Mechanisms of glucose intolerance in cystic fibrosis. (19538232)
2009
31
Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. (19164473)
2009
32
Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet. (17971509)
2008
33
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. (18308938)
2008
34
Complete nucleotide sequence of a coxsackievirus B4 strain that establishes infection in ICR mice pancreas and induces glucose intolerance. (18384052)
2008
35
Risk of glucose intolerance and diabetes in hemipancreatectomized donors selected for normal preoperative glucose metabolism. (18469205)
2008
36
Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats. (18828926)
2008
37
Prevalence of diabetes and glucose intolerance in an ethnically diverse rural community of Hawaii. (17682354)
2007
38
The close association between low economic status and glucose intolerance in elderly subjects in a rural area in Laos. (18081687)
2007
39
Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). (16390206)
2006
40
Glucose intolerance in a xenotransplantation model: studies in alpha-gal knockout mice. (17078862)
2006
41
Amelioration of non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice by oral immune regulation towards liver-extracted proteins is associated with elevated intrahepatic NKT lymphocytes and serum IL-10 levels. (16261527)
2006
42
Glucose intolerance in Wisconsin's Hmong population. (16138509)
2005
43
Glucose intolerance: the hidden danger in hypertensives! (16158028)
2005
44
Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses. (15842514)
2005
45
Serum levels of soluble tumor necrosis factor-alpha receptor 2 are linked to insulin resistance and glucose intolerance in children. (15679072)
2005
46
Oxidative stress and antioxidant status in elderly diabetes mellitus and glucose intolerance patients. (15381345)
2004
47
Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors. (15331545)
2004
48
Glucose intolerance and serum aminotransferase activities in Japanese men. (12480555)
2003
49
Amniotic fluid insulin at 14-20 weeks' gestation: association with later maternal glucose intolerance and birth macrosomia. (11423512)
2001
50
Abnormal glucagon response to arginine and its normalization in obese hyperinsulinaemic patients with glucose intolerance: importance of insulin action on pancreatic alpha cells. (1769438)
1991

Genetic Variations for Glucose Intolerance

Expression for genes affiliated with Glucose Intolerance

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Glucose Intolerance

Search GEO for disease gene expression data for Glucose Intolerance.

Pathways for genes affiliated with Glucose Intolerance

Sources:
4Cell Signaling Technology, 53R&D Systems, 54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB, 52QIAGEN
See all sources

Pathways related to Glucose Intolerance according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6ADIPOQ, TXN, PDX1, LIPE, GYS1, PCK2
2
Hide members
10.5RBP4, GYS1, RETN, INS, SLC2A4, ADIPOQ
3
Hide members
10.5GCK, PDX1, INS, PAX6, PAX4
4
Translation Insulin regulation of translation
Hide members
10.5GCK, LIPE, GYS1, PCK2, INS, SLC2A4
5
Hide members
10.5GCK, PDX1, INS, SLC2A4, ADIPOQ
610.5LIPE, PCK2, RETN, INS, SLC2A4, ADIPOQ
710.5SLC2A4, INS, GYS1, LIPE
810.5ADIPOQ, SLC2A4, GYS1, LIPE
910.5GCK, PDX1, IGFBP1, INS
1010.5INS, PDX1, GCK
1110.5LIPE, GYS1, SLC2A4, ENPP1
1210.5GYS1, INS, SLC2A4
1310.5PDX1, IGFBP1, INS
14
Hide members
10.5GCK, GYS1, PCK2, SLC2A4
1510.5ADIPOQ, SLC2A4, PCK2
16
Hide members
10.5SLC2A4, PCK2, GCK

Compounds for genes affiliated with Glucose Intolerance

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Glucose Intolerance according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1lipid4511.1SHBG, GCK, CAPN10, LSL, RBP4, LIPE
2fatty acid4511.0SERPINA6, SLC2A4, INS, RETN, PCK2, IGFBP1
3glucose4511.0ENPP1, SERPINA6, PAX4, PAX6, SLC2A4, PCK2
4dexamethasone45 50 29 1114.0ADRB3, TXN, GCK, LSL, SERPINA6, ADIPOQ
5cholesterol45 29 11 2414.0LIPE, IGFBP1, PCK2, RETN, INS, SERPINA6
6glycogen45 2412.0ADIPOQ, ENPP1, INS, RETN, PCK2, IGFBP1
7alanine4511.0ADRB3, ADIPOQ, SERPINA6, PAX6, SLC2A4, INS
8c-peptide4511.0PDX1, SHBG, IGFBP1, RETN, INS, ADIPOQ
9rosiglitazone45 50 29 11 2415.0RETN, INS, SLC2A4, ADIPOQ, PCK2, IGFBP1
10lactate4511.0RBP4, TXN, GCK, LSL, SHBG, LIPE
11metformin45 50 1113.0GCK, LSL, SHBG, IGFBP1, RETN, INS
12testosterone45 60 11 2414.0LSL, ADIPOQ, SERPINA6, SLC2A4, TXN, RBP4
13thyroxine45 2412.0LSL, TXN, RBP4, SHBG, RETN, SERPINA6
14glycerol45 11 2413.0INS, GCK, LSL, SHBG, IGFBP1, LIPE
15dehydroepiandrosterone sulfate4511.0IGFBP1, ADIPOQ, LSL, RBP4, SHBG, SERPINA6
16arginine4511.0SHBG, CAPN10, LSL, IGFBP1, INS, PAX6
17carbohydrates4511.0SHBG, TXN, GCK, ADIPOQ, SERPINA6, INS
18androstenedione45 2411.9IGFBP1, SERPINA6, LSL, RBP4, SHBG, INS
19creatinine4510.9INS, SLC2A4, SHBG, ADIPOQ, RETN, RBP4
20dhea4510.9SHBG, ADIPOQ, INS, RETN, IGFBP1, SERPINA6
21pioglitazone45 50 29 1113.9IGFBP1, SHBG, RBP4, SLC2A4, ADIPOQ, INS
22streptozotocin4510.9GCK, PDX1, PCK2, INS, SLC2A4, ADIPOQ
232-deoxyglucose45 1111.9ADIPOQ, INS, IGFBP1, LIPE, SLC2A4, GCK
24phosphatidylinositol4510.9LSL, PDX1, GYS1, IGFBP1, PCK2, RETN
25norepinephrine45 11 2412.9RETN, LIPE, SLC2A4, ADRB3
26sulfonylurea4510.9ADIPOQ, SLC2A4, INS, PDX1, GCK
27triacylglycerol4510.9PCK2, INS, ADIPOQ, LIPE, RBP4, LSL
2817-hydroxyprogesterone45 2411.9IGFBP1, RETN, SERPINA6, ADIPOQ, SHBG
29estrogen4510.9ADRB3
30triiodothyronine4510.9IGFBP1, SHBG, PCK2, RBP4, LSL, SERPINA6
31serine4510.9SLC2A4, PAX6, RBP4, GCK, TXN, ADIPOQ
32vitamin a45 11 2412.9SERPINA6, PCK2, IGFBP1, RBP4, ADIPOQ, RETN
33thiazolidinedione4510.8ADIPOQ, SLC2A4, PCK2, RETN, INS
34retinoic acid45 2411.8ADIPOQ, PAX6, IGFBP1, RBP4, PDX1, TXN
35uric acid45 2411.8ADRB3
3611beta-hydroxysteroid4510.8RETN, PCK2, ADIPOQ, SLC2A4, SERPINA6
37aicar45 11 2412.8SLC2A4, ADIPOQ, GCK, PCK2, INS
38epinephrine45 11 2412.8LSL, GYS1, ADRB3, INS, LIPE, IGFBP1
39hydrocortisone45 2 60 1113.8ADIPOQ, SERPINA6, IGFBP1, LSL, INS, SHBG
40glycerol 3-phosphate45 2411.8ADIPOQ, SLC2A4, GCK, LIPE, PCK2
41aspartate4510.8ADIPOQ, LIPE, RETN, SHBG, LSL, RBP4
42olanzapine50 45 29 11 2414.7SLC2A4, LSL, ADRB3, ADIPOQ, INS
43adenylate4510.7LIPE, ADIPOQ, TXN, GCK, ADRB3, SHBG
44acipimox45 2911.7INS, ADIPOQ, LSL, LIPE
45glimepiride45 50 1112.6INS, SLC2A4, ADIPOQ, RETN
46sterol4510.6GCK, PCK2, SLC2A4, ADIPOQ, LIPE, RETN
47gliclazide45 50 1112.5GYS1, SLC2A4, ADIPOQ, INS
48forskolin45 50 1112.5PDX1, RETN
49nash4510.4INS, RETN, LSL, ADIPOQ
50progesterone45 60 29 11 2414.2LSL, GCK, IGFBP1, SHBG, RETN, SLC2A4

GO Terms for genes affiliated with Glucose Intolerance

Sources:
16Gene Ontology
See all sources

Cellular components related to Glucose Intolerance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5RBP4, SHBG, IGFBP1, RETN, INS, ADIPOQ
2extracellular spaceGO:00561510.3ADIPOQ, RBP4, IGFBP1, RETN, INS, SERPINA6

Biological processes related to Glucose Intolerance according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1glucose homeostasisGO:04259310.9ADIPOQ, PAX6, SLC2A4, INS, RBP4, PDX1
2cellular response to insulin stimulusGO:03286910.8GCK, CAPN10, SLC2A4, ENPP1, ADIPOQ
3glucose metabolic processGO:00600610.8ADIPOQ, INS, PCK2, GYS1, PDX1
4positive regulation of insulin secretionGO:03202410.8GCK, CAPN10, PDX1, RBP4
5endocrine pancreas developmentGO:03101810.8PAX4, INS, PDX1, GCK
6negative regulation of gluconeogenesisGO:04572110.8GCK, INS, ADIPOQ
7generation of precursor metabolites and energyGO:00609110.8ADRB3, ADIPOQ, ENPP1, PDX1
8positive regulation of glucose importGO:04632610.8ADIPOQ, INS, CAPN10
9small molecule metabolic processGO:04428110.8TXN, GCK, LIPE, GYS1, PCK2, INS
10brown fat cell differentiationGO:05087310.8SLC2A4, ADIPOQ, ADRB3
11carbohydrate metabolic processGO:00597510.7GCK, GYS1, PCK2, SLC2A4, ADRB3
12detection of glucoseGO:05159410.7PDX1, GCK
13glucose transportGO:01575810.7GCK, INS, SLC2A4
14negative regulation of protein autophosphorylationGO:03195310.6ADIPOQ, ENPP1
15response to ethanolGO:04547110.6ADIPOQ, SLC2A4, RBP4
16positive regulation of glycolysisGO:04582110.5GCK, INS
17positive regulation of glycogen biosynthetic processGO:04572510.5INS, GCK
18organ morphogenesisGO:00988710.4PAX4, PAX6, PDX1
19positive regulation of cellular protein metabolic processGO:03227010.2ADIPOQ, INS

Molecular functions related to Glucose Intolerance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.6GYS1, LIPE, RBP4, GCK, PCK2, INS
2glucose bindingGO:00553610.4GYS1, GCK
3hormone activityGO:00517910.2ADIPOQ, INS, RETN

Products for genes affiliated with Glucose Intolerance

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Glucose Intolerance

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet