MCID: GLC003
MIFTS: 58

Glucose Intolerance malady

Gastrointestinal diseases category

Summaries for Glucose Intolerance

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66Wikipedia, 34MalaCards
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Wikipedia:66 Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with... more...

MalaCards: Glucose Intolerance, also known as impaired glucose tolerance, is related to obesity and hypertension. An important gene associated with Glucose Intolerance is INS (insulin), and among its related pathways are Insulin-mediated glucose transport and FOXA2 and FOXA3 transcription factor networks. The drug glucomannan and the compounds gliclazide and liraglutide have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and skeletal muscle, and related mouse phenotypes are cardiovascular system and adipose tissue.

Aliases & Classifications for Glucose Intolerance

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

glucose intolerance 9 11 46
impaired glucose tolerance 63
malabsorption of glucose 9
malabsorption syndrome 63
glucose: intolerance 9
malabsorption 9


External Ids:

Disease Ontology9 DOID:10603
MeSH36 D018149
ICD1026 K90.4

Related Diseases for Glucose Intolerance

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Glucose Intolerance via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 405)
idRelated DiseaseScoreTop Affiliating Genes
1obesity31.2INS, SERPINA6, ADRB3, ADIPOQ, IAPP, RETN
2hypertension31.1RETN, ADRB3, INS
3polycystic ovary syndrome31.1INS, CAPN10
4insulin resistance31.0IAPP, ADIPOQ, ADRB3, PAX4, SERPINA6, INS
5cystic fibrosis30.8INS, CAPN10, RBP4
6gestational diabetes30.6RBP4, CAPN10, RETN, IAPP, ADIPOQ, ADRB3
7diabetes mellitus30.6PDX1, CAPN10, RETN, GYS1, IAPP, ADIPOQ
8myocardial infarction30.5PDX1, RETN, ADIPOQ
9hypertriglyceridemia30.5INS, ADRB3, ADIPOQ
10acromegaly30.4RETN, ADIPOQ, INS
11atherosclerosis30.3INS, ADRB3, ADIPOQ, RETN, CAPN10, RBP4
12fatty liver disease30.3INS, RETN, RBP4
13hyperglycemia30.3PDX1, RETN, GYS1, IAPP, ADIPOQ, ADRB3
14hyperandrogenism30.3INS, ADIPOQ, RETN, CAPN10
15type 2 diabetes mellitus30.2RBP4, PDX1, CAPN10, RETN, GYS1, IAPP
16hyperinsulinism30.1RETN, INS
17hyperthyroidism30.1INS, SERPINA6, RETN
18infertility30.1CAPN10, RETN, INS
19hypercholesterolemia30.1INS, ADIPOQ, RETN, CAPN10, PDX1, RBP4
20proteinuria30.1INS, ADIPOQ, RBP4
21hypogonadism30.1ADIPOQ, INS
22hypoglycemia30.0INS, SERPINA6, IAPP, GYS1
23coronary artery disease30.0INS, ADRB3, ADIPOQ, RETN
24insulinoma30.0PDX1, IAPP, PAX4, INS
25breast cancer29.9INS, SERPINA6, ADRB3, IAPP, RBP4
26essential hypertension29.9INS, ADRB3, ADIPOQ, IAPP, RETN
27amyloidosis29.8RBP4, IAPP
28primary hyperoxaluria29.6RBP4, RETN, IAPP
29type 1 diabetes mellitus29.4INS, PAX4, ADRB3, IAPP, RETN, PDX1
30hepatitis10.7
31pancreatitis10.7
32hereditary folate malabsorption10.6
33neuronitis10.4
34tropical sprue10.4
35lactose intolerance10.4
36diarrhea10.4
37acute myocardial infarction10.3
38steatorrhea10.3
39pernicious anemia10.3
40hepatitis c10.3
41blind loop syndrome10.3
42exocrine pancreatic insufficiency10.2
43protein-losing enteropathy10.2
44megaloblastic anemia10.2
45gastritis10.2
46burns10.2
47primary hyperparathyroidism10.2
48cerebritis10.2
49artery disease10.2
50cataract10.2

Graphical network of the top 20 diseases related to Glucose Intolerance:



Diseases related to glucose intolerance

Symptoms for Glucose Intolerance

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Drugs & Therapeutics for Glucose Intolerance

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Glucose Intolerance

Drug clinical trials:

Search ClinicalTrials for Glucose Intolerance

Search NIH Clinical Center for Glucose Intolerance

Search CenterWatch for Glucose Intolerance

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Glucose Intolerance

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Anatomical Context for Glucose Intolerance

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34MalaCards
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MalaCards organs/tissues related to Glucose Intolerance:

34
Ovary, Liver, Skeletal muscle, Pancreas, Testes, Heart, Kidney, Hypothalamus, Pancreatic islet, Brain, T cells, Monocytes, Breast, Adipocyte, Endothelial, Prostate, Thyroid, Pituitary, Bone

Animal Models for Glucose Intolerance or affiliated genes

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38MGI
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Publications for Glucose Intolerance

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53PubMed
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Articles related to Glucose Intolerance:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats. (23793169)
2013
2
Intrauterine protein restriction combined with early postnatal overfeeding was not associated with adult-onset obesity but produced glucose intolerance by pancreatic dysfunction. (23305533)
2013
3
Testosterone promotes glucose intolerance, lipid disorder and oxidative stress in type 1 diabetic rats. (23729563)
2013
4
Assessment of the magnitude of contextual and individual demographic effects on diabetes mellitus and glucose intolerance in rural Southwest China: a multilevel analysis. (23874667)
2013
5
Aldosterone aggravates glucose intolerance induced by high fructose. (24201309)
2013
6
Identification of prognostic and diagnostic biomarkers of glucose intolerance in ApoE3Leiden mice. (22234995)
2012
7
Dietary saponins of sea cucumber ameliorate obesity, hepatic steatosis, and glucose intolerance in high-fat diet-fed mice. (22897583)
2012
8
Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice. (22953037)
2012
9
Difference in glucose intolerance between C57BL/6J and ICR strain mice with streptozotocin/nicotinamide-induced diabetes. (22361889)
2012
10
Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-I+ in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice. (22518292)
2012
11
Elevated IgG levels against specific bacterial antigens in obese patients with diabetes and in mice with diet-induced obesity and glucose intolerance. (22424821)
2012
12
Women with gestational diabetes develop glucose intolerance with high frequency within one year postpartum. (22086200)
2012
13
Maternal low-protein diet up-regulates the neuropeptide Y system in visceral fat and leads to abdominal obesity and glucose intolerance in a sex- and time-specific manner. (22539639)
2012
14
Low molecular weight compounds from Zoanthus sociatus impair insulin secretion via Ca(+2) influx blockade and cause glucose intolerance inA vivo. (22155304)
2012
15
Effect of conversion from twice-daily to once-daily tacrolimus on glucose intolerance in stable kidney transplant recipients. (22310593)
2012
16
Newly diagnosed glucose intolerance and prognosis after acute myocardial infarction: comparison of post-challenge versus fasting glucose concentrations. (22581733)
2012
17
Pregravid physical activity, dietary intake, and glucose intolerance during pregnancy. (21951267)
2011
18
A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. (21751816)
2011
19
Non-catch-up growth in intrauterine growth-retarded rats showed glucose intolerance and increased expression of PDX-1 mRNA. (20626638)
2011
20
Sox9-haploinsufficiency causes glucose intolerance in mice. (21829703)
2011
21
Maternal cigarette smoke exposure contributes to glucose intolerance and decreased brain insulin action in mice offspring independent of maternal diet. (22076142)
2011
22
The effects of physical activity, body mass index (BMI) and waist circumference (WC) on glucose intolerance in older people: a nationwide study from Taiwan. (20206389)
2011
23
The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy. (20855478)
2010
24
Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice. (20716529)
2010
25
Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. (20299475)
2010
26
Free-living physical activity energy expenditure is strongly related to glucose intolerance in Cameroonian adults independently of obesity. (19017776)
2009
27
Circulating soluble CD36 is associated with glucose metabolism and interleukin-6 in glucose-intolerant men. (19156623)
2009
28
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. (19478200)
2009
29
Increased prevalence of obesity and glucose intolerance in youth treated with second-generation antipsychotic medications. (19961662)
2009
30
Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. (19224198)
2009
31
Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study. (19703913)
2009
32
WITHDRAWN: P.P.2 04 Chronological observation of glucose intolerance in myotonic dystrophy. (19324549)
2009
33
Reduced skeletal muscle capillarization and glucose intolerance. (19225985)
2009
34
Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. (18840361)
2008
35
Scientists find clues to glucose intolerance. (18398071)
2008
36
Lifestyle changes after oral glucose tolerance test improve glucose intolerance in community-dwelling elderly people after 1 year. (18380685)
2008
37
Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice. (17161234)
2007
38
Treatment of hypertension with thiazides: benefit or damage-effect of low- and high-dose thiazide diuretics on arterial elasticity and metabolic parameters in hypertensive patients with and without glucose intolerance. (17684458)
2007
39
Glucose intolerance during hormonal therapy for prostate cancer. (17486109)
2007
40
Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice. (16378704)
2006
41
A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. (16804070)
2006
42
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. (16025115)
2005
43
HMG-CoA reductase inhibitors do not improve glucose intolerance in spontaneously diabetic Goto-Kakizaki rats. (16272695)
2005
44
Dietary diacylglycerol reduces postprandial hyperlipidemia and ameliorates glucose intolerance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. (16023327)
2005
45
Maternal and perinatal magnesium restriction predisposes rat pups to insulin resistance and glucose intolerance. (15930437)
2005
46
Clustering of protective factors for glucose intolerance and insulin resistance: a cross-sectional study. (16026378)
2005
47
Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice. (15970590)
2005
48
Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease. (11231980)
2001
49
Maternal glucose intolerance and the subcutaneous terbutaline pump. (1550166)
1992
50
Pathogenic factors responsible for glucose intolerance in patients with NIDDM. (1446794)
1992

Variations for Glucose Intolerance

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Expression for genes affiliated with Glucose Intolerance

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Glucose Intolerance

Search GEO for disease gene expression data for Glucose Intolerance.

Pathways for genes affiliated with Glucose Intolerance

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Sources:
51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 31KEGG, 52PharmGKB, 5Cell Signaling Technology, 56Reactome, 55R&D Systems, 61Thomson Reuters, 54QIAGEN
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Pathways related to Glucose Intolerance according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GYS1, INS
29.7PDX1, INS
39.5GYS1, ADIPOQ
49.4IAPP, INS
59.3ADIPOQ, RETN
69.3RETN, ADIPOQ
79.0INS, ADIPOQ, RETN
8
Show member pathways
9.0PDX1, ADIPOQ, INS
98.8INS, IAPP, PDX1
108.7PDX1, GYS1, ADIPOQ, INS
11
Show member pathways
8.5PDX1, IAPP, PAX4, INS
12
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.3INS, ADIPOQ, GYS1, RETN, RBP4
13
Show member pathways
7.9INS, PAX4, ADIPOQ, IAPP, PDX1

Compounds for genes affiliated with Glucose Intolerance

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Glucose Intolerance according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1gliclazide46 52 1211.6GYS1, INS, ADIPOQ
2liraglutide46 30 1211.5IAPP, INS
3repaglinide52 46 1211.5PAX4, IAPP, INS
4exenatide46 1210.4IAPP, INS
5nash469.4INS, ADIPOQ, RETN
6glimepiride46 52 1211.4ADIPOQ, RETN, INS
7olanzapine46 52 30 25 1213.4ADIPOQ, ADRB3, INS
8thiazolidinedione469.4RETN, INS, ADIPOQ
98-isoprostane469.4ADIPOQ, INS, RETN
1017-hydroxyprogesterone46 2510.3SERPINA6, ADIPOQ, RETN
11fructosamine46 2510.3IAPP, RBP4, INS
12fenofibrate46 52 1211.3ADIPOQ, RETN, INS
13triacylglycerol469.3ADIPOQ, RBP4, INS
1411beta-hydroxysteroid469.3ADIPOQ, SERPINA6, RETN
15i-app469.3IAPP, INS, PDX1
16incretin469.2IAPP, INS, PDX1
17dehydroepiandrosterone sulfate469.2RBP4, ADIPOQ, SERPINA6, INS
18androstenedione46 2510.2INS, ADIPOQ, SERPINA6, RBP4
19dhea469.1ADIPOQ, INS, SERPINA6, RETN
20sitagliptin46 1210.1IAPP, INS
21pioglitazone30 46 52 1212.0INS, ADIPOQ, RETN, RBP4
22glibenclamide46 30 52 6212.0INS, ADIPOQ, IAPP
23rosiglitazone30 46 52 25 1212.9RETN, RBP4, ADIPOQ, INS
24epinephrine46 25 1210.9IAPP, GYS1, ADRB3, INS
25vitamin a46 25 1210.8ADIPOQ, SERPINA6, RETN, RBP4
26thyroxine46 259.7INS, SERPINA6, ADIPOQ, RETN, RBP4
27sulfonylurea468.7PDX1, IAPP, ADIPOQ, INS
28streptozotocin468.6ADIPOQ, IAPP, PDX1, INS
29metformin46 52 1210.6ADIPOQ, RETN, INS, IAPP
30uric acid46 259.6INS, RETN, RBP4, ADRB3, ADIPOQ
31p002468.4ADIPOQ, RETN, IAPP, RBP4
32phosphatidylinositol468.4ADIPOQ, INS, RETN, GYS1, PDX1
33fatty acid468.3ADRB3, RBP4, RETN, ADIPOQ, SERPINA6, INS
34norepinephrine46 25 1210.2IAPP, INS, ADRB3, ADIPOQ, RETN
35alanine468.2RETN, RBP4, INS, SERPINA6, ADRB3, ADIPOQ
36forskolin46 52 1210.2IAPP, PDX1, RETN, GYS1
37estrogen468.2SERPINA6, RETN, ADIPOQ, INS, RBP4, ADRB3
38estradiol46 25 1210.2SERPINA6, ADIPOQ, IAPP, RETN
39adenylate468.1SERPINA6, IAPP, ADIPOQ, ADRB3, RBP4
40creatinine468.1RETN, RBP4, ADIPOQ, INS, IAPP
41arginine468.0SERPINA6, ADRB3, INS, ADIPOQ, IAPP, CAPN10
42cysteine468.0CAPN10, SERPINA6, RBP4, IAPP, RETN
43testosterone46 62 25 1210.8INS, RBP4, SERPINA6, ADIPOQ, IAPP, RETN
44c-peptide467.7ADIPOQ, IAPP, INS, ADRB3, RETN, PDX1
45serine467.6INS, RBP4, PDX1, IAPP, ADIPOQ, SERPINA6
46glycogen46 258.6CAPN10, RETN, GYS1, IAPP, ADIPOQ, ADRB3
47dexamethasone46 52 30 1210.5SERPINA6, IAPP, ADIPOQ, ADRB3, INS, RBP4
48cholesterol46 30 25 1210.1RBP4, CAPN10, IAPP, ADIPOQ, ADRB3, SERPINA6
49lipid466.8RETN, INS, RBP4, CAPN10, GYS1, IAPP
50glucose465.9IAPP, RBP4, INS, SERPINA6, PAX4, ADRB3

GO Terms for genes affiliated with Glucose Intolerance

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17Gene Ontology
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Cellular components related to Glucose Intolerance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.4RBP4, RETN, IAPP, ADIPOQ, SERPINA6, INS

Biological processes related to Glucose Intolerance according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell differentiationGO:04559710.0INS, PAX4
2negative regulation of feeding behaviorGO:20002529.9RETN, INS
3positive regulation of MAPK cascadeGO:0434109.8ADRB3, INS
4negative regulation of gluconeogenesisGO:0457219.8ADIPOQ, INS
5positive regulation of cellular protein metabolic processGO:0322709.7INS, ADIPOQ
6circadian rhythmGO:0076239.6ADIPOQ, PAX4
7brown fat cell differentiationGO:0508739.5ADIPOQ, ADRB3
8positive regulation of glucose importGO:0463269.5CAPN10, ADIPOQ, INS
9response to insulinGO:0328689.4RETN, RBP4
10eating behaviorGO:0427559.4IAPP, ADRB3
11positive regulation of insulin secretionGO:0320249.4RBP4, PDX1, CAPN10
12cellular response to insulin stimulusGO:0328699.2CAPN10, ADIPOQ
13generation of precursor metabolites and energyGO:0060919.2ADRB3, ADIPOQ, PDX1
14glucose metabolic processGO:0060069.0INS, ADIPOQ, GYS1, PDX1
15glucose homeostasisGO:0425938.9INS, ADIPOQ, PDX1, RBP4
16endocrine pancreas developmentGO:0310188.8PDX1, IAPP, PAX4, INS

Molecular functions related to Glucose Intolerance according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.2RETN, IAPP, ADIPOQ, INS

Products for genes affiliated with Glucose Intolerance

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Sources for Glucose Intolerance

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet