MCID: GLC003
MIFTS: 50

Glucose Intolerance malady

Gastrointestinal diseases category

Summaries for Glucose Intolerance

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MedlinePlus:32 Your small intestine does most of the digesting of the foods you eat. if you have a malabsorption syndrome, your small intestine cannot absorb nutrients from foods. causes of malabsorption syndromes include celiac disease lactose intolerance short bowel syndrome. this happens after surgery to remove half or more of the small intestine. you might need the surgery if you have a problem with the small intestine from a disease, injury, or birth defect. whipple disease, a rare bacterial infection genetic diseases certain medicines symptoms of different malabsorption syndromes can vary. they often include chronic diarrhea, abnormal stools, weight loss, and gas. your doctor may use lab, imaging, or other tests to make a diagnosis. treatment of malabsorption syndromes depends on the cause.

MalaCards based summary: Glucose Intolerance, also known as malabsorption, is related to polycystic ovary syndrome and liver disease. An important gene associated with Glucose Intolerance is INS (insulin), and among its related pathways are Insulin-mediated glucose transport and FOXA2 and FOXA3 transcription factor networks. The drug glucomannan and the compounds gliclazide and liraglutide have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and ovary, and related mouse phenotypes are cardiovascular system and adipose tissue.

Aliases & Classifications for Glucose Intolerance

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Glucose Intolerance, Aliases & Descriptions:

Name: Glucose Intolerance 9 11 43
Malabsorption 9 43
Impaired Glucose Tolerance 60
Malabsorption of Glucose 9
 
Malabsorption Syndromes 32
Malabsorption Syndrome 60
Glucose: Intolerance 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:10603
MeSH33 D018149
ICD1025 K90.4

Related Diseases for Glucose Intolerance

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Diseases related to Glucose Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 424)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.4CAPN10, INS
2liver disease31.1INS
3cystic fibrosis30.9RBP4, INS, CAPN10
4hypertriglyceridemia30.5INS, ADRB3, ADIPOQ
5acromegaly30.5RETN, ADIPOQ, INS
6fatty liver disease30.5RBP4, RETN, INS
7hyperinsulinism30.4INS, RETN
8hyperthyroidism30.3INS, SERPINA6, RETN
9myocardial infarction30.3RETN, ADIPOQ, PDX1
10infertility30.2INS, RETN, CAPN10
11hyperandrogenism30.1RETN, ADIPOQ, CAPN10, INS
12proteinuria30.1ADIPOQ, RBP4, INS
13hypogonadism30.1INS, ADIPOQ
14obesity30.1INS, SERPINA6, ADRB3, ADIPOQ, IAPP, CAPN10
15hypoglycemia29.9INS, IAPP, GYS1, SERPINA6
16coronary artery disease29.9ADRB3, INS, ADIPOQ, RETN
17hypothyroidism29.9ADIPOQ, RETN
18atherosclerosis29.9RBP4, CAPN10, ADIPOQ, ADRB3, INS, RETN
19insulinoma29.8INS, PDX1, PAX4, IAPP
20amyloidosis29.6RBP4, IAPP
21primary hyperoxaluria29.5RETN, RBP4, IAPP
22breast cancer29.4IAPP, RBP4, INS, ADRB3, SERPINA6
23hyperglycemia29.2INS, PAX4, ADRB3, ADIPOQ, IAPP, GYS1
24hepatitis10.8
25pancreatitis10.7
26diabetic ketoacidosis10.5INS
27neuronitis10.5
28folate malabsorption, hereditary10.5
29morbid obesity10.5INS
30tropical sprue10.4
31diarrhea10.4
32pancreatic agenesis10.4PDX1
33megaloblastic anemia10.4
34acute myocardial infarction10.4
35steatorrhea10.3
36lactose intolerance10.3
37blind loop syndrome10.3
38pernicious anemia10.3
39insulin-like growth factor i10.3
40hepatitis c10.3
41cerebritis10.3
42artery disease10.3
43ischemia10.3
44endotheliitis10.3
45sucrase-isomaltase deficiency, congenital10.3
46diabetes mellitus, permanent neonatal10.3PDX1, INS
47neonatal diabetes mellitus10.3INS, PDX1
48hyperuricemia10.3INS, ADRB3
49bile acid malabsorption, primary10.3
50exocrine pancreatic insufficiency10.3

Graphical network of the top 20 diseases related to Glucose Intolerance:



Diseases related to glucose intolerance

Symptoms for Glucose Intolerance

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Drugs & Therapeutics for Glucose Intolerance

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Drug clinical trials:

Search ClinicalTrials for Glucose Intolerance

Search NIH Clinical Center for Glucose Intolerance

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Glucose Intolerance

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Anatomical Context for Glucose Intolerance

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MalaCards organs/tissues related to Glucose Intolerance:

31
Testes, Small intestine, Ovary, Liver, Skeletal muscle, Pancreas, Heart, Brain, Kidney, Endothelial, Hypothalamus, Pancreatic islet, Adipocyte, Breast, Monocytes, T cells, Bone, Thyroid, Prostate, Pituitary

Animal Models for Glucose Intolerance or affiliated genes

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Publications for Glucose Intolerance

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Articles related to Glucose Intolerance:

(show top 50)    (show all 616)
idTitleAuthorsYear
1
Arsenic Exposure and Glucose Intolerance/Insulin Resistance in Estrogen-Deficient Female Mice. (25859628)
2015
2
The effect of combined treatment with canagliflozin and teneligliptin on glucose intolerance in Zucker diabetic fatty rats. (25892328)
2015
3
Iron metabolism is prospectively associated with insulin resistance and glucose intolerance over a 7-year follow-up period: the CODAM study. (25267079)
2014
4
Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet. (25406017)
2014
5
The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases. (25170916)
2014
6
Brain-derived neurotrophic factor inhibits glucose intolerance after cerebral ischemia. (25206547)
2013
7
Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats. (23793169)
2013
8
Intrauterine protein restriction combined with early postnatal overfeeding was not associated with adult-onset obesity but produced glucose intolerance by pancreatic dysfunction. (23305533)
2013
9
Testosterone promotes glucose intolerance, lipid disorder and oxidative stress in type 1 diabetic rats. (23729563)
2013
10
Assessment of the magnitude of contextual and individual demographic effects on diabetes mellitus and glucose intolerance in rural Southwest China: a multilevel analysis. (23874667)
2013
11
Identification of prognostic and diagnostic biomarkers of glucose intolerance in ApoE3Leiden mice. (22234995)
2012
12
Dietary saponins of sea cucumber ameliorate obesity, hepatic steatosis, and glucose intolerance in high-fat diet-fed mice. (22897583)
2012
13
Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice. (22953037)
2012
14
Difference in glucose intolerance between C57BL/6J and ICR strain mice with streptozotocin/nicotinamide-induced diabetes. (22361889)
2012
15
Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-I+ in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice. (22518292)
2012
16
Elevated IgG levels against specific bacterial antigens in obese patients with diabetes and in mice with diet-induced obesity and glucose intolerance. (22424821)
2012
17
Women with gestational diabetes develop glucose intolerance with high frequency within one year postpartum. (22086200)
2012
18
Maternal low-protein diet up-regulates the neuropeptide Y system in visceral fat and leads to abdominal obesity and glucose intolerance in a sex- and time-specific manner. (22539639)
2012
19
Low molecular weight compounds from Zoanthus sociatus impair insulin secretion via Ca(+2) influx blockade and cause glucose intolerance inA vivo. (22155304)
2012
20
Pregravid physical activity, dietary intake, and glucose intolerance during pregnancy. (21951267)
2011
21
A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. (21751816)
2011
22
Non-catch-up growth in intrauterine growth-retarded rats showed glucose intolerance and increased expression of PDX-1 mRNA. (20626638)
2011
23
Sox9-haploinsufficiency causes glucose intolerance in mice. (21829703)
2011
24
Maternal cigarette smoke exposure contributes to glucose intolerance and decreased brain insulin action in mice offspring independent of maternal diet. (22076142)
2011
25
The effects of physical activity, body mass index (BMI) and waist circumference (WC) on glucose intolerance in older people: a nationwide study from Taiwan. (20206389)
2011
26
The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy. (20855478)
2010
27
Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice. (20716529)
2010
28
Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. (20299475)
2010
29
Free-living physical activity energy expenditure is strongly related to glucose intolerance in Cameroonian adults independently of obesity. (19017776)
2009
30
Circulating soluble CD36 is associated with glucose metabolism and interleukin-6 in glucose-intolerant men. (19156623)
2009
31
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. (19478200)
2009
32
Increased prevalence of obesity and glucose intolerance in youth treated with second-generation antipsychotic medications. (19961662)
2009
33
Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. (19224198)
2009
34
Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study. (19703913)
2009
35
WITHDRAWN: P.P.2 04 Chronological observation of glucose intolerance in myotonic dystrophy. (19324549)
2009
36
Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. (18840361)
2008
37
Scientists find clues to glucose intolerance. (18398071)
2008
38
Lifestyle changes after oral glucose tolerance test improve glucose intolerance in community-dwelling elderly people after 1 year. (18380685)
2008
39
Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice. (17161234)
2007
40
Treatment of hypertension with thiazides: benefit or damage-effect of low- and high-dose thiazide diuretics on arterial elasticity and metabolic parameters in hypertensive patients with and without glucose intolerance. (17684458)
2007
41
A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. (16804070)
2006
42
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. (16025115)
2005
43
HMG-CoA reductase inhibitors do not improve glucose intolerance in spontaneously diabetic Goto-Kakizaki rats. (16272695)
2005
44
Dietary diacylglycerol reduces postprandial hyperlipidemia and ameliorates glucose intolerance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. (16023327)
2005
45
Maternal and perinatal magnesium restriction predisposes rat pups to insulin resistance and glucose intolerance. (15930437)
2005
46
Clustering of protective factors for glucose intolerance and insulin resistance: a cross-sectional study. (16026378)
2005
47
Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice. (15970590)
2005
48
Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease. (11231980)
2001
49
Maternal glucose intolerance and the subcutaneous terbutaline pump. (1550166)
1992
50
Pathogenic factors responsible for glucose intolerance in patients with NIDDM. (1446794)
1992

Variations for Glucose Intolerance

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Expression for genes affiliated with Glucose Intolerance

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Search GEO for disease gene expression data for Glucose Intolerance.

Pathways for genes affiliated with Glucose Intolerance

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Pathways related to Glucose Intolerance according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GYS1, INS
29.7PDX1, INS
39.5GYS1, ADIPOQ
49.0INS, ADIPOQ, RETN
5
Show member pathways
9.0PDX1, ADIPOQ, INS
68.7PDX1, GYS1, ADIPOQ, INS
7
Show member pathways
8.5PDX1, IAPP, PAX4, INS
8
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.3INS, ADIPOQ, GYS1, RETN, RBP4
9
Show member pathways
7.9INS, PAX4, ADIPOQ, IAPP, PDX1

Compounds for genes affiliated with Glucose Intolerance

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Compounds related to Glucose Intolerance according to GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1gliclazide43 49 1211.6INS, ADIPOQ, GYS1
2liraglutide43 28 1211.5IAPP, INS
3repaglinide49 43 1211.5IAPP, PAX4, INS
4exenatide43 1210.4IAPP, INS
5nash439.4INS, ADIPOQ, RETN
6glimepiride43 49 1211.4INS, ADIPOQ, RETN
7olanzapine43 49 28 24 1213.4INS, ADRB3, ADIPOQ
8thiazolidinedione439.4INS, ADIPOQ, RETN
98-isoprostane439.4INS, ADIPOQ, RETN
1017-hydroxyprogesterone43 2410.3SERPINA6, ADIPOQ, RETN
11fructosamine43 2410.3INS, IAPP, RBP4
12fenofibrate43 49 1211.3INS, ADIPOQ, RETN
13triacylglycerol439.3INS, ADIPOQ, RBP4
1411beta-hydroxysteroid439.3SERPINA6, ADIPOQ, RETN
15i-app439.3PDX1, IAPP, INS
16incretin439.2PDX1, IAPP, INS
17dehydroepiandrosterone sulfate439.2INS, SERPINA6, ADIPOQ, RBP4
18androstenedione43 2410.2RBP4, ADIPOQ, SERPINA6, INS
19dhea439.1INS, SERPINA6, ADIPOQ, RETN
20sitagliptin43 1210.1INS, IAPP
21pioglitazone28 43 49 1212.0INS, ADIPOQ, RETN, RBP4
22glibenclamide43 28 49 5912.0IAPP, ADIPOQ, INS
23rosiglitazone28 43 49 24 1212.9INS, ADIPOQ, RETN, RBP4
24epinephrine43 24 1210.9GYS1, IAPP, ADRB3, INS
25vitamin a43 24 1210.8RBP4, RETN, ADIPOQ, SERPINA6
26thyroxine43 249.7INS, SERPINA6, ADIPOQ, RETN, RBP4
27sulfonylurea438.7PDX1, IAPP, ADIPOQ, INS
28streptozotocin438.6PDX1, IAPP, ADIPOQ, INS
29metformin43 49 1210.6INS, ADIPOQ, IAPP, RETN
30uric acid43 249.6INS, ADRB3, ADIPOQ, RETN, RBP4
31p002438.4RBP4, RETN, IAPP, ADIPOQ
32phosphatidylinositol438.4PDX1, RETN, GYS1, ADIPOQ, INS
33fatty acid438.3INS, SERPINA6, ADRB3, ADIPOQ, RETN, RBP4
34norepinephrine43 24 1210.2INS, ADRB3, ADIPOQ, IAPP, RETN
35alanine438.2INS, SERPINA6, ADRB3, ADIPOQ, RETN, RBP4
36forskolin43 49 1210.2PDX1, RETN, GYS1, IAPP
37estrogen438.2INS, SERPINA6, ADRB3, ADIPOQ, RETN, RBP4
38estradiol43 24 1210.2SERPINA6, ADIPOQ, IAPP, RETN
39adenylate438.1RBP4, IAPP, ADIPOQ, ADRB3, SERPINA6
40creatinine438.1RBP4, RETN, IAPP, ADIPOQ, INS
41arginine438.0INS, SERPINA6, ADRB3, ADIPOQ, IAPP, CAPN10
42cysteine438.0RBP4, CAPN10, RETN, IAPP, SERPINA6
43testosterone43 59 24 1210.8INS, SERPINA6, ADIPOQ, IAPP, RETN, RBP4
44c-peptide437.7INS, ADRB3, ADIPOQ, IAPP, RETN, PDX1
45serine437.6INS, SERPINA6, ADIPOQ, IAPP, PDX1, RBP4
46glycogen43 248.6INS, ADRB3, ADIPOQ, IAPP, GYS1, RETN
47dexamethasone43 49 28 1210.5INS, SERPINA6, ADRB3, ADIPOQ, IAPP, RETN
48cholesterol43 28 24 1210.1INS, SERPINA6, ADRB3, ADIPOQ, IAPP, RETN
49lipid436.8INS, SERPINA6, ADRB3, ADIPOQ, IAPP, GYS1
50glucose435.9RBP4, INS, SERPINA6, PAX4, ADRB3, ADIPOQ

GO Terms for genes affiliated with Glucose Intolerance

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Cellular components related to Glucose Intolerance according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.4RBP4, RETN, IAPP, ADIPOQ, SERPINA6, INS

Biological processes related to Glucose Intolerance according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell differentiationGO:004559710.0INS, PAX4
2negative regulation of feeding behaviorGO:020002529.9RETN, INS
3positive regulation of MAPK cascadeGO:00434109.8ADRB3, INS
4negative regulation of gluconeogenesisGO:00457219.8ADIPOQ, INS
5positive regulation of cellular protein metabolic processGO:00322709.7INS, ADIPOQ
6circadian rhythmGO:00076239.6ADIPOQ, PAX4
7brown fat cell differentiationGO:00508739.5ADIPOQ, ADRB3
8positive regulation of glucose importGO:00463269.5CAPN10, ADIPOQ, INS
9response to insulinGO:00328689.4RETN, RBP4
10eating behaviorGO:00427559.4IAPP, ADRB3
11positive regulation of insulin secretionGO:00320249.4RBP4, PDX1, CAPN10
12cellular response to insulin stimulusGO:00328699.2CAPN10, ADIPOQ
13generation of precursor metabolites and energyGO:00060919.2ADRB3, ADIPOQ, PDX1
14glucose metabolic processGO:00060069.0INS, ADIPOQ, GYS1, PDX1
15glucose homeostasisGO:00425938.9INS, ADIPOQ, PDX1, RBP4
16endocrine pancreas developmentGO:00310188.8PDX1, IAPP, PAX4, INS

Molecular functions related to Glucose Intolerance according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.2RETN, IAPP, ADIPOQ, INS

Products for genes affiliated with Glucose Intolerance

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Sources for Glucose Intolerance

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3CDC
13ExPASy
14FMA
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23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
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