MCID: GLC003
MIFTS: 55

Glucose Intolerance malady

Categories: Metabolic diseases

Aliases & Classifications for Glucose Intolerance

Aliases & Descriptions for Glucose Intolerance:

Name: Glucose Intolerance 12 29 52 42 14
Impaired Glucose Tolerance 69
Malabsorption of Glucose 12
Fatty Stool 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10603
ICD10 33 R73.09
MeSH 42 D018149
NCIt 47 C34646
UMLS 69 C0271650

Summaries for Glucose Intolerance

MalaCards based summary : Glucose Intolerance, also known as impaired glucose tolerance, is related to steatorrhea and lipodystrophy, familial partial, 2. An important gene associated with Glucose Intolerance is INS (Insulin), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Metformin and Saxagliptin have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and skeletal muscle, and related phenotypes are adipose tissue and endocrine/exocrine gland

Related Diseases for Glucose Intolerance

Diseases related to Glucose Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
id Related Disease Score Top Affiliating Genes
1 steatorrhea 11.1
2 lipodystrophy, familial partial, 2 11.0
3 estrogen resistance 10.8
4 obesity 10.6
5 intellectual disability-developmental delay-contractures syndrome 10.3 INS INSR
6 acute infection of pinna 10.3 CRP INS
7 hepatitis 10.3
8 brain angioma 10.3 IGF1 IRS1
9 diabetes mellitus, insulin-dependent, 2 10.3 IGFBP1 INS SHBG
10 acrocephalopolydactyly 10.3 ADIPOQ LEP RETN
11 malignant perineurioma 10.3 ADIPOQ LEP RETN
12 joint disorders 10.2 CRP INS LPL
13 mucinoses 10.2 ADIPOQ LEP RETN
14 pancreatitis 10.2
15 gestational diabetes 10.2
16 diarrhea 3, secretory sodium, congenital, syndromic 10.2 IGF1 INS INSR
17 polycystic ovary syndrome 10.2
18 diabetic cataract 10.2 GCK INS INSR
19 cortical blindness mental retardation polydactyly 10.2 ADIPOQ LEP RETN
20 microphthalmia, syndromic 8 10.2 GCG INS
21 autosomal recessive congenital ichthyosis 10.2 INS LEP SLC2A4
22 not otherwise specified 3-mga-uria type 10.2 ADIPOQ INS LEP RETN
23 thymus clear cell carcinoma 10.2 ADIPOQ INS LEP RETN
24 seow najjar syndrome 10.2 IGF1 INS
25 hyperinsulinemic hypoglycemia, familial, 5 10.2 IGF1 INS INSR IRS1
26 glomangiomyoma 10.2 GHRL INS LEP SHBG
27 papillary craniopharyngioma 10.2 GHRL IGF1 INS
28 aflatoxins-related hepatocellular carcinoma 10.2 IGF1 INS SHBG
29 autoimmune disease 1 10.2 CRP GCG INS
30 pyrimidine metabolic disorder 10.2 ADIPOQ CRP INS LPL
31 capillary lymphangioma 10.1 IGF1 INS SHBG
32 bile duct mucoepidermoid carcinoma 10.1 CRP LEP LPL RETN
33 leg dermatosis 10.1 ADIPOQ INS INSR LEP SHBG
34 autoimmune-related retinopathy and optic neuropathy 10.1 ADIPOQ CRP INS LPL
35 thrombophilia 10.1 GHRL IGF1 IGFBP1 INS
36 immunodeficiency 18 10.1 ADIPOQ INS LPL
37 exophthalmic ophthalmoplegia 10.1 ADIPOQ LEP LEPR
38 pinguecula 10.1 IGF1 IGFBP1 INS SHBG
39 epidural spinal canal meningioma 10.1 IGF1 INS LEP SHBG
40 pericarditis 10.1 ADIPOQ CRP INS LPL RETN
41 macular degeneration, age-related, 12 10.1 ADIPOQ CRP INS LPL RETN
42 maturity-onset diabetes of the young, type 13 10.1 GCG GCK INS
43 roifman-chitayat syndrome 10.1 ADIPOQ GHRL IGF1 LEP
44 cystic fibrosis 10.1
45 extrahepatic bile duct adenocarcinoma 10.1 IGF1 IGFBP1 SHBG
46 cleft lip palate-tetraphocomelia 10.1 LEP LEPQTL1
47 cholesteatoma 10.1 ADIPOQ GHRL LEP LEPR
48 pelvic muscle wasting 10.1 IGF1 IGFBP1 INS INSR SHBG
49 chronic tic disorder 10.0 ADIPOQ IGFBP1 LEP LEPR
50 hyperlipoproteinemia type iv 10.0 ADIPOQ CRP DPP4 INS LEP

Graphical network of the top 20 diseases related to Glucose Intolerance:



Diseases related to Glucose Intolerance

Symptoms & Phenotypes for Glucose Intolerance

MGI Mouse Phenotypes related to Glucose Intolerance:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 10.26 ADIPOQ ADRB3 GHRL IGF1 INS INSR
2 endocrine/exocrine gland MP:0005379 10.22 ADIPOQ ADRB3 DPP4 GCK GHRL IGF1
3 homeostasis/metabolism MP:0005376 10.22 IGF1 INS INSR IRS1 LEP LEPR
4 cardiovascular system MP:0005385 10.2 LPL RBP4 SLC2A4 ADIPOQ CRP IGF1
5 cellular MP:0005384 10.17 IGFBP1 INS INSR IRS1 LEP LEPR
6 growth/size/body region MP:0005378 10.15 ADIPOQ ADRB3 DPP4 GCK IGF1 INS
7 immune system MP:0005387 10 ADIPOQ CRP IGF1 IGFBP1 INS INSR
8 liver/biliary system MP:0005370 9.9 IGFBP1 INS INSR IRS1 LEP LEPR
9 muscle MP:0005369 9.65 IRS1 LEP LEPR LPL RBP4 SLC2A4
10 renal/urinary system MP:0005367 9.17 ADIPOQ GCK IGF1 INS INSR LEP

Drugs & Therapeutics for Glucose Intolerance

Drugs for Glucose Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 553)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
2
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
3
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
4
Acarbose Approved, Investigational Phase 4,Phase 3 56180-94-0 441184
5
Insulin Glargine Approved Phase 4,Phase 3,Phase 1 160337-95-1
6
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
7
Paclitaxel Approved, Vet_approved Phase 4 33069-62-4 36314
8
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
9
Ethanol Approved Phase 4,Phase 3 64-17-5 702
10
Voglibose Approved, Investigational Phase 4 83480-29-9 444020
11
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
12
Testosterone Approved, Investigational Phase 4,Phase 3 58-22-0 6013
13
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
14
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
15
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 1 141758-74-9 15991534
16
Valsartan Approved, Investigational Phase 4,Phase 3 137862-53-4 60846
17
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 111025-46-8 4829
18
Hydroxychloroquine Approved Phase 4 118-42-3 3652
19
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 58-93-5 3639
20
Lisinopril Approved, Investigational Phase 4 83915-83-7 5362119
21
Losartan Approved Phase 4,Phase 2 114798-26-4 3961
22
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
23
Nateglinide Approved, Investigational Phase 4,Phase 3 105816-04-4 60026
24
Telmisartan Approved, Investigational Phase 4,Phase 2 144701-48-4 65999
25
Amlodipine Approved Phase 4 88150-42-9 2162
26
Copper Approved Phase 4 15158-11-9, 7440-50-8 27099
27
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
28
Budesonide Approved Phase 4 51333-22-3 63006 5281004
29
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
30
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
31
Abacavir Approved, Investigational Phase 4 136470-78-5 65140 441300
32
Lamivudine Approved, Investigational Phase 4,Phase 3 134678-17-4 60825
33
Lopinavir Approved Phase 4 192725-17-0 92727
34
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
35
Zidovudine Approved Phase 4,Phase 3 30516-87-1 35370
36
Trandolapril Approved Phase 4 87679-37-6 5484727
37
Verapamil Approved Phase 4 52-53-9 2520
38
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 1,Phase 2 128794-94-5 5281078
39
Mycophenolic acid Approved Phase 4,Phase 1,Phase 2 24280-93-1 446541
40
Cyclosporine Approved, Investigational, Vet_approved Phase 4 79217-60-0, 59865-13-3 5284373 6435893
41
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 22916-47-8 4189
42
Daclizumab Approved, Investigational Phase 4 152923-56-3
43
Tacrolimus Approved, Investigational Phase 4,Phase 1,Phase 2 104987-11-3 445643 439492
44
Basiliximab Approved, Investigational Phase 4 152923-56-3, 179045-86-4
45
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 53-03-2 5865
46
Darunavir Approved Phase 4 635728-49-3, 206361-99-1 213039
47
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
48
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
49
Liraglutide Approved Phase 4,Phase 3,Phase 2 204656-20-2
50
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783

Interventional clinical trials:

(show top 50) (show all 960)
id Name Status NCT ID Phase
1 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4
2 Curcumin Therapy in Patients With Impaired Glucose Tolerance and Insulin Resistance Unknown status NCT01052025 Phase 4
3 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4
4 Intensity of Exercise and Glucose Metabolism Unknown status NCT01649219 Phase 4
5 Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial) Unknown status NCT00858676 Phase 4
6 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4
7 Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients Unknown status NCT02057523 Phase 4
8 Comparing a Nucleoside-Analogue-Sparing Regimen and a Protease-Inhibitor-Sparing Regimen in HIV Infected Patients Unknown status NCT00135460 Phase 4
9 A Clinical Trial of Paclitaxel Loaded Polymeric Micelle in Patients With Taxane-Pretreated Recurrent Breast Cancer Unknown status NCT00912639 Phase 4
10 Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT) Completed NCT00301392 Phase 4
11 Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes Completed NCT02700334 Phase 4
12 Effects of Physical Activity on the Brain in Impaired Glucose Tolerance (IGT) Completed NCT01219231 Phase 4
13 The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes Completed NCT00546728 Phase 4
14 Physical Exercise Versus Rosiglitazone in CAD and Prediabetes Completed NCT00675740 Phase 4
15 Effects of Antidiabetic Medications on the Postprandial State in Prediabetes Completed NCT02104739 Phase 4
16 Effect of Rubus Occidentalis Extract on Plasma Glucose Levels in Subject With Prediabetes Completed NCT01964703 Phase 4
17 Effects of Vitamin D on Beta Cell Function and Insulin Sensitivity in Pre-diabetes and Diabetes Mellitus Type 2 Completed NCT01497132 Phase 4
18 Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study) Completed NCT00928005 Phase 4
19 Clinical Trial To Evaluate The Effect Of Valsartan On Insulin Sensitivity In Subjects With Impaired Glucose Tolerance Completed NCT00241072 Phase 4
20 Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance Completed NCT00108615 Phase 4
21 Effect of Anthocyanins on Metabolic Profiles in Subjects With Pre-diabetes Completed NCT02689765 Phase 4
22 Sitagliptin in Renal Transplant Recipients Completed NCT00740363 Phase 4
23 Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes Completed NCT01326533 Phase 4
24 Postmarketing Clinical Study on AO-128 Completed NCT02287402 Phase 4
25 Metformin and Longevity Genes in Prediabetes Completed NCT01765946 Phase 4
26 The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose Completed NCT00673790 Phase 4
27 Efficacy and Safety of Nateglinide Treatment in Renal Transplant Recipients Completed NCT00319189 Phase 4
28 Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus Completed NCT01436916 Phase 4
29 Sitagliptin Improved Beta Cell Function and Prevented a Conversion Rate to Impaired Glucose Tolerance and Type 2 Diabetes in Metformin Intolerant Obese Women With Polycystic Ovary Syndrome Completed NCT03122041 Phase 4
30 Telmisartan and Losartan in Hypertensive IGT Completed NCT00407862 Phase 4
31 The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes Completed NCT01181986 Phase 4
32 Comparison of Valsartan With Amlodipine in Hypertensive Patients With Glucose Intolerance Completed NCT00129233 Phase 4
33 Acute Effect of Exenatide on Brain Glucose Metabolism Completed NCT01588418 Phase 4
34 Incretins in Impaired Fasting Glucose Completed NCT00364377 Phase 4
35 The Effect of Korean Red Ginseng Supplementation on Glucose Control Completed NCT01911663 Phase 4
36 Mechanisms Underlying Metabolic Syndrome in Obesity Completed NCT00579813 Phase 4
37 Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction Completed NCT00627744 Phase 4
38 The Effect of Exenatide on Weight and Hunger in Obese, Healthy Women Completed NCT00456885 Phase 4
39 Effect of Acarbose on Postprandial Lipoprotein Levels in Glucose Intolerant Patients Completed NCT02355509 Phase 4
40 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4
41 Study to Determine the Effects of Human Growth Hormone and Pioglitazone in Overweight, Prediabetic Adults Completed NCT00352287 Phase 4
42 Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function Completed NCT00845182 Phase 4
43 Effects of Exenatide on Postprandial Hyperlipidemia and Inflammation Completed NCT00974272 Phase 4
44 Postpartum Glucose Tolerance With Levonorgesterel IUD Use in Women With Recent Gestational Diabetes Completed NCT01022645 Phase 4
45 The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion Completed NCT01056497 Phase 4
46 Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH) Completed NCT00227110 Phase 4
47 Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes Completed NCT00212290 Phase 4
48 Application and Effectiveness Analysis of Internet-based Diabetes Prevention Program Completed NCT01085682 Phase 4
49 The Effect of Vitamin D Supplementation in Type 2 Diabetes Completed NCT01854463 Phase 4
50 Effect of Vitamin D Supplementation on Fasting Glucose and Interleukin-10 (IL-10) in Arab Women With Impaired Fasting Glucose Completed NCT00877123 Phase 4

Search NIH Clinical Center for Glucose Intolerance

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: glucose intolerance

Genetic Tests for Glucose Intolerance

Genetic tests related to Glucose Intolerance:

id Genetic test Affiliating Genes
1 Glucose Intolerance 29

Anatomical Context for Glucose Intolerance

MalaCards organs/tissues related to Glucose Intolerance:

39
Ovary, Liver, Skeletal Muscle, Pancreas, Testes, Heart, Adipocyte

Publications for Glucose Intolerance

Articles related to Glucose Intolerance:

(show top 50) (show all 704)
id Title Authors Year
1
Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice. ( 27997218 )
2017
2
Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats. ( 27871838 )
2017
3
Arsenite in drinking water produces glucose intolerance in pregnant rats and their female offspring. ( 28017702 )
2017
4
Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. ( 28089395 )
2017
5
Changes in the expression of the type 2 diabetes-associated gene VPS13C in the I^-cell are associated with glucose intolerance in humans and mice. ( 27329800 )
2016
6
Maternal Glucose Intolerance Reduces Offspring Nephron Endowment and Increases Glomerular Volume in Adult Offspring. ( 27037899 )
2016
7
Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice. ( 27685945 )
2016
8
Is vaspin related to cardio-metabolic status and autonomic function in early stages of glucose intolerance and in metabolic syndrome? ( 27462373 )
2016
9
Transgenerational Glucose Intolerance of Tumor Necrosis Factor with Epigenetic Alteration in Rat Perirenal Adipose Tissue Induced by Intrauterine Hyperglycemia. ( 26881249 )
2016
10
Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT). ( 27373781 )
2016
11
Involvement of communication system between brain and peripheral tissues on the development of post-ischemic glucose intolerance induced by cerebral neuronal damage. ( 27430677 )
2016
12
Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice. ( 26943364 )
2016
13
Glucose intolerance develops prior to increased adiposity and accelerated cessation of estrous cyclicity in female growth-restricted rats. ( 26854801 )
2016
14
Loss of Nlrp3 Does Not Protect Mice from Western Diet-Induced Adipose Tissue Inflammation and Glucose Intolerance. ( 27583382 )
2016
15
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. ( 26868208 )
2016
16
Dimethylesculetin ameliorates maternal glucose intolerance and fetal overgrowth in high-fat diet-fed pregnant mice via constitutive androstane receptor. ( 27426490 )
2016
17
Risk factors for postpartum glucose intolerance in women with gestational diabetes mellitus. ( 27113701 )
2016
18
3-Deoxyglucosone Induced Acute Glucose Intolerance in Sprague-Dawley Rats: Involvement of Insulin Resistance and Impaired I^-cell Function. ( 26824285 )
2016
19
Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in RetnlI^ (RELMI^) Null Mice: A Model of Intestinal Immune System Dysfunction in Disease Susceptibility. ( 27397737 )
2016
20
First Trimester Maternal Glycated Hemoglobin and Sex Hormone-Binding Globulin Do Not Predict Third Trimester Glucose Intolerance of Pregnancy. ( 27613817 )
2016
21
One-hour post-load plasma glucose level during the OGTT predicts mortality: observations from the Israel Study of Glucose Intolerance, Obesity and Hypertension. ( 26996391 )
2016
22
I+B-crystallin and HspB2 deficiency is protective from diet-induced glucose intolerance. ( 27330996 )
2016
23
Exogenous thyroxine improves glucose intolerance in insulin resistant rats. ( 27980001 )
2016
24
Predictive markers for abnormal glucose intolerance in women with polycystic ovary syndrome. ( 27348441 )
2016
25
Interaction of BDNF rs6265 variants and energy and protein intake in the risk for glucose intolerance and type 2 diabetes in middle-aged adults. ( 27553771 )
2016
26
Insulin resistance precedes glucose intolerance and hyperleptinaemia in high-fat simple carbohydrate-fed C57BL/6J mice. ( 28042652 )
2016
27
Glucoregulatory, endocrine and morphological effects of [P5K]hymenochirin-1B in mice with diet-induced glucose intolerance and insulin resistance. ( 27068334 )
2016
28
Microflora Disturbance during Progression of Glucose Intolerance and Effect of Sitagliptin: An Animal Study. ( 27631013 )
2016
29
N-Acetyl-L-Cysteine inhibits the development of glucose intolerance and hepatic steatosis in diabetes-prone mice. ( 27725855 )
2016
30
Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression. ( 27001279 )
2016
31
Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle lipotoxicity in normal chow-fed mice: compared to diet-induced obesity. ( 27567590 )
2016
32
The Subgingival Microbiome, Systemic Inflammation and Insulin Resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS). ( 27978598 )
2016
33
Gender-Specific Mechanisms Underlying the Amelioration of High-Fat Diet-Induced Glucose Intolerance in B-Cell-Activating Factor Deficient Mice. ( 27814392 )
2016
34
Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study. ( 27825389 )
2016
35
Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice. ( 27055280 )
2016
36
Burned Adults Develop Profound Glucose Intolerance. ( 26934145 )
2016
37
Glycemic Effects of Rebaudioside A and Erythritol in People with Glucose Intolerance. ( 27352150 )
2016
38
Glucose intolerance associated with hypoxia in people living at high altitudes in the Tibetan highland. ( 26908520 )
2016
39
Early glucose intolerance in patients started on corticosteroids. ( 27728170 )
2016
40
Glucose intolerance after chronic stress is related with downregulated PPAR-I^ in adipose tissue. ( 27538526 )
2016
41
Predictive markers for abnormal glucose intolerance in women with polycystic ovary syndrome. ( 27152717 )
2016
42
Arterial Effects of Canakinumab in PatientsA With Atherosclerosis and TypeA 2A Diabetes or Glucose Intolerance. ( 27737744 )
2016
43
Relationship of glycemic control markers - 1,5 anhydroglucitol, fructosamine, and glycated hemoglobin among Asian Indians with different degrees of glucose intolerance. ( 27730082 )
2016
44
Glucocorticoid Antagonism Limits Adiposity Rebound and Glucose Intolerance in Young Male Rats Following the Cessation of Daily Exercise and Caloric Restriction. ( 27143556 )
2016
45
Methodological considerations when studying the skeletal response to glucose intolerance using the diet-induced obesity model. ( 27818742 )
2016
46
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance. ( 27323669 )
2016
47
Corrigendum to "Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent". ( 27703478 )
2016
48
Catch-up growth following food restriction exacerbates adulthood glucose intolerance in pigs exposed toA intrauterineA undernutrition. ( 27210508 )
2016
49
Insulin receptor isoform A ameliorates long term glucose intolerance in diabetic mice. ( 27562101 )
2016
50
A safflower oil-based high fat/high-sucrose diet modulates the gut microbiota and liver phospholipid profiles associated with early glucose intolerance in the absence of tissue inflammation. ( 28012235 )
2016

Variations for Glucose Intolerance

Expression for Glucose Intolerance

Search GEO for disease gene expression data for Glucose Intolerance.

Pathways for Glucose Intolerance

Pathways related to Glucose Intolerance according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 GCK IGF1 INS INSR IRS1 SLC2A4
2
Show member pathways
12.75 ADIPOQ INS INSR IRS1 LEP RBP4
3
Show member pathways
12.48 INS INSR IRS1 LPL SLC2A4
4
Show member pathways
12.45 GCK INS IRS1 LEP LEPR
5
Show member pathways
12.43 IGF1 INS INSR IRS1
6 12.41 ADIPOQ GCG IGFBP1 INS INSR IRS1
7
Show member pathways
12.27 ADRB3 IGF1 INSR IRS1
8
Show member pathways
12.21 DPP4 GCG GHRL IGF1 INS LEP
9
Show member pathways
12.19 INS INSR IRS1 LEP SLC2A4
10
Show member pathways
12.17 ADIPOQ IGF1 INS INSR IRS1 LEP
11
Show member pathways
12.12 ADIPOQ IGF1 INS INSR IRS1
12
Show member pathways
12.05 IGF1 INS INSR IRS1 SLC2A4
13
Show member pathways
11.92 INS INSR IRS1 SLC2A4
14 11.83 IGF1 INS INSR
15 11.78 ADIPOQ IGF1 INS LEP LPL SLC2A4
16
Show member pathways
11.72 ADIPOQ GCK INS INSR IRS1 SLC2A4
17 11.69 INS LPL RBP4
18 11.67 ADIPOQ IRS1 LEP LEPR SLC2A4
19 11.64 INS INSR IRS1
20 11.63 GCK IGFBP1 LEP
21 11.57 ADRB3 INS INSR IRS1
22
Show member pathways
11.56 DPP4 GCG LEP
23 11.54 IRS1 LEP LEPR SLC2A4
24 11.5 IGF1 INS INSR
25 11.47 INS INSR IRS1 LEP LEPR
26 11.44 GCK IGFBP1 INS
27 11.42 INS INSR IRS1
28 11.36 IGF1 INS INSR IRS1
29 11.35 ADIPOQ IGF1 INS IRS1 LEP LPL
30
Show member pathways
11.24 CRP LEP LEPR
31 11.21 INS INSR SLC2A4
32
Show member pathways
10.95 INSR IRS1 SLC2A4
33 10.86 INS SLC2A4
34 10.7 ADIPOQ INSR IRS1 LEP SLC2A4

GO Terms for Glucose Intolerance

Cellular components related to Glucose Intolerance according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ADIPOQ CRP GCG GHRL IGF1 IGFBP1
2 endoplasmic reticulum lumen GO:0005788 9.56 GCG GHRL IGFBP1 INS
3 extracellular region GO:0005576 9.47 ADIPOQ CRP DPP4 GCG GHRL IGF1
4 insulin receptor complex GO:0005899 9.16 INSR IRS1

Biological processes related to Glucose Intolerance according to GeneCards Suite gene sharing:

(show all 40)
id Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.96 ADRB3 GCK INS INSR SLC2A4
2 response to ethanol GO:0045471 9.88 ADIPOQ LEP RBP4 SLC2A4
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 ADIPOQ IGF1 INS
4 positive regulation of protein kinase B signaling GO:0051897 9.85 INS INSR LEP
5 response to insulin GO:0032868 9.83 IRS1 LEP RETN
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.82 IGF1 INS LEP
7 insulin receptor signaling pathway GO:0008286 9.81 IGFBP1 INS INSR IRS1
8 regulation of insulin secretion GO:0050796 9.8 DPP4 GCG GCK LEP
9 positive regulation of MAPK cascade GO:0043410 9.8 ADRB3 IGF1 INS INSR LEP
10 positive regulation of insulin secretion GO:0032024 9.78 GCK GHRL RBP4
11 positive regulation of DNA replication GO:0045740 9.77 IGF1 INS INSR
12 glucose transport GO:0015758 9.77 GCK INS SLC2A4
13 cellular response to insulin stimulus GO:0032869 9.77 ADIPOQ GCK INSR IRS1 SLC2A4
14 brown fat cell differentiation GO:0050873 9.74 ADIPOQ ADRB3 SLC2A4
15 activation of protein kinase B activity GO:0032148 9.72 IGF1 INS INSR
16 glucose metabolic process GO:0006006 9.72 ADIPOQ GCK GHRL INS LEP
17 positive regulation of mitotic nuclear division GO:0045840 9.71 IGF1 INS INSR
18 positive regulation of cellular protein metabolic process GO:0032270 9.68 ADIPOQ INS
19 insulin-like growth factor receptor signaling pathway GO:0048009 9.68 IGF1 IRS1
20 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.67 ADIPOQ CRP
21 sexual reproduction GO:0019953 9.67 LEP LEPR
22 cellular response to leptin stimulus GO:0044320 9.66 GCK LEP
23 adult feeding behavior GO:0008343 9.66 GHRL LEP
24 negative regulation of lipid storage GO:0010888 9.65 CRP LEP
25 leptin-mediated signaling pathway GO:0033210 9.65 LEP LEPR
26 energy reserve metabolic process GO:0006112 9.65 ADRB3 LEP LEPR
27 negative regulation of vasodilation GO:0045908 9.64 CRP INS
28 regulation of bone remodeling GO:0046850 9.63 LEP LEPR
29 positive regulation of respiratory burst GO:0060267 9.63 INS INSR
30 positive regulation of glycolytic process GO:0045821 9.63 IGF1 INS INSR
31 negative regulation of feeding behavior GO:2000252 9.62 INS RETN
32 positive regulation of developmental growth GO:0048639 9.62 INSR LEP
33 bone mineralization involved in bone maturation GO:0035630 9.61 IGF1 LEP
34 positive regulation of insulin receptor signaling pathway GO:0046628 9.61 INS IRS1 LEP
35 negative regulation of gluconeogenesis GO:0045721 9.56 ADIPOQ GCK INS LEPR
36 positive regulation of glucose import GO:0046326 9.55 ADIPOQ IGF1 INS INSR IRS1
37 bone growth GO:0098868 9.52 LEP LEPR
38 positive regulation of glycogen biosynthetic process GO:0045725 9.35 GCK IGF1 INS INSR IRS1
39 glucose homeostasis GO:0042593 9.28 ADIPOQ GCK INS INSR IRS1 LEP
40 positive regulation of cell proliferation GO:0008284 10.05 DPP4 IGF1 INS INSR IRS1 LEP

Molecular functions related to Glucose Intolerance according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.63 ADIPOQ DPP4 GCG IGFBP1 LEP LPL
2 insulin receptor binding GO:0005158 9.43 IGF1 INS IRS1
3 insulin-like growth factor I binding GO:0031994 9.37 IGFBP1 INSR
4 insulin-like growth factor II binding GO:0031995 9.32 IGFBP1 INSR
5 insulin-like growth factor receptor binding GO:0005159 9.26 IGF1 INS INSR IRS1
6 hormone activity GO:0005179 9.17 ADIPOQ GCG GHRL IGF1 INS LEP

Sources for Glucose Intolerance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....