Glucose Intolerance malady

Wikipedia: Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with...⁴⁴ more...

MalaCards: Glucose Intolerance, also known as malabsorption of glucose (disorder), is related to obesity and insulin resistance. An important gene associated with Glucose Intolerance is PAX4 (paired box 4), and among its related pathways are Aldosterone-regulated sodium reabsorption and Maturity onset diabetes of the young. The drug glucomannan and the compounds 2-deoxyglucose and glimepiride have been mentioned in the context of this disorder. Affiliated tissues include heart, skeletal muscle and liver, and related mouse phenotypes are hematopoietic system and respiratory system.

Aliases & Descriptions:

glucose intolerance 6 8 32 malabsorption of glucose (disorder) 6 impaired glucose tolerance 43

malabsorption syndrome 43 glucose: intolerance 6 malabsorption 6

Diseases related to glucose intolerance by text searches and GeneDecks gene sharing:

(show top 50)    (show all 843)

id	Related Disease	Score	Top Affiliating Genes
1	obesity	35.9	ENPP1, GHRL, ADRB3
2	insulin resistance	35.0	LEPR, UCP2, MT-ND3, IRS1, INS, PPARGC1A
3	hepatitis	33.1	GPT, IFNA1, SLC17A5
4	polycystic ovary syndrome	31.8	LEP, IRS1, IRS2, INS, INSR, IGFBP1
5	fatty liver disease	30.9	PPARA, SLC17A5, ADIPOQ
6	acute lymphoblastic leukemia	30.4	COG2, LEPR, INPP5D, IL6R, APOB, IGFBP1
7	acute insulin response	30.1	GCG, KCNJ11, UCP2, INS, CRP, ABCC8
8	persistent hyperinsulinemic hypoglycemia of infancy	30.0	GCK, KCNJ11, ABCC8
9	breast cancer	29.9	IRS1, IRS2, APC, FASN, GHR, NR3C1
10	hypoglycemia of infancy	29.8	GCK, KCNJ11, INS, SST, PDX1, ABCC8
11	hyperinsulinemic hypoglycemia	29.7	INS, SST, ABCC8
12	hepatitis c	29.3	IL6R, GPT, IFNA1, HP, TXN, TNF
13	carotid intimal medial thickness	29.3	SERPINE1, LPL, INS, IL6, APOC3, TNF
14	gestational diabetes	29.3	RETN, GCK, GCG, RBP4, KCNJ11, LEP
15	hypokalemia	29.2	INS, ALB, SST, NR3C1, ACE, NPY
16	hyperinsulinism	28.8	RETN, GCK, GCG, SERPINE1, LPL, VCAM1
17	morbid obesity	28.5	RETN, GCG, LPL, LEP, LEPR, INS
18	xanthomatosis	28.2	LPL, INS, APOA1, APOB
19	retinol binding protein	27.9	RETN, PCK2, RBP4, CKM, LEP, IRS1
20	hellp syndrome	27.7	SERPINE1, LEP, IL6, GPT, HP, TPO
21	acanthocytosis	27.7	LPL, INSR, APOB, PRL
22	abetalipoproteinemia	27.5	LPL, LEP, APOA1, APOB, IGF1, PRL
23	primary hyperparathyroidism	27.4	SERPINE1, LEP, CD36, INS, IL6, IL6R
24	sleep disorder	27.4	VCAM1, LEP, INS, IL6, IL6R, ALB
25	short bowel syndrome	26.9	GCG, LEP, IGF1, ALB, GH1, TNF
26	sepsis	26.5	RETN, RBP4, SERPINA6, SERPINE1, LPL, IRS1
27	hyperparathyroidism	26.5	SERPINE1, SCG5, LEP, CD36, INS, IL6
28	insulinoma	26.5	GCK, GCG, BTC, PAX4, KCNJ11, SCG5
29	type 2 diabetes mellitus	25.8	COG2, RETN, PCBD1, PCK2, GCK, GCG
30	lateral sclerosis	25.8	SERPINE1, LPL, CKM, APOB, APOC3, ANGPT2
31	hypertriglyceridemia	25.6	COG2, RBP4, SERPINE1, LPL, VCAM1, LMNA
32	primary hyperoxaluria	25.4	GCG, LPL, LEP, INS, APOB, APOC3
33	myotonic dystrophy	25.3	GCG, LMNA, CKM, LEP, INS, INSR
34	lymphoblastic leukemia	25.2	COG2, SERPINE1, LPL, PAX4, LEP, LEPR
35	hyperandrogenism	25.1	RETN, LMNA, LEP, CD36, IRS1, IRS2
36	polyneuropathy	25.1	RBP4, INS, IL6, APOA1, APOB, GPT
37	diarrhea	25.1	GCG, KCNJ11, INS, IL6, GPT, IFNA1
38	hypogonadism	25.0	PIK3AP1, RETN, SERPINA6, SERPINE1, LMNA, LEP
39	acromegaly	24.7	RETN, GCG, RBP4, SERPINE1, LPL, SCG5
40	hypoglycemia	24.4	PCK2, GCK, GCG, SERPINA6, LPL, KCNJ11
41	proteinuria	24.4	COG2, RBP4, SERPINE1, VCAM1, LEP, INS
42	obesity, association with	24.3	RETN, RBP4, SERPINE1, LIPE, LEP, LEPR
43	type 1 diabetes mellitus	23.9	RETN, GCK, GCG, RBP4, PAX4, LEP
44	gastritis	23.7	VCAM1, LEP, INS, IL6, APOA1, ALB
45	diabetic retinopathy	23.6	RBP4, SERPINE1, VCAM1, LEP, UCP2, INS
46	hyperlipidemia	23.3	COG2, RETN, GCK, RBP4, SERPINE1, LPL
47	thalassemia	23.3	VCAM1, CKM, LEP, INS, IL6, GPT
48	hypercholesterolemia	23.0	COG2, RETN, GCG, RBP4, SERPINE1, LPL
49	cystic fibrosis	22.8	RBP4, LPL, KCNJ11, LEP, CD36, INS
50	essential hypertension	22.1	COG2, RETN, GCK, SERPINE1, LPL, VCAM1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 glucomannan

MalaCards organs/tissues related to glucose intolerance:

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MGI Mouse Phenotypes related to glucose intolerance:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.4	PIK3AP1, INPP5D, APC, DLK1
2	respiratory system phenotype	MP:0005388	10.1	INPPL1, INSR, PPARGC1A, NEUROD1, GAD2, INPP5D
3	endocrine/exocrine gland phenotype	MP:0005379	9.9	SCG5, GHR, NNT, ABCC8, DPP4, NEUROD1
4	pigmentation phenotype	MP:0001186	9.6	CCL2, APOB, APC, IRS2, LEP, KCNJ11
5	integument phenotype	MP:0010771	9.5	TNFRSF1B, NR3C1, PDX1, PRL, ERN1, ANGPT2
6	renal/urinary system phenotype	MP:0005367	9.3	PAX6, LEPR, IRS2, INS, INSR, GSK3B
7	no phenotypic analysis	MP:0003012	9.2	HNF1A, GHRL, SST, PPARG, ST3GAL4, ENPP2
8	skeleton phenotype	MP:0005390	9.2	IGF1, IAPP, HNF1A, TNFRSF1B, DLK1, PPARG
9	digestive/alimentary phenotype	MP:0005381	8.6	GCG, LMNA, LIPE, PAX6, LEP, LEPR
10	nervous system phenotype	MP:0003631	8.5	TNFRSF1B, NR3C1, HIF1A, TSHR, PRL, NPY
11	normal phenotype	MP:0002873	8.2	NR3C1, PPARG, SST, ERN1, GHRL, PDX1
12	reproductive system phenotype	MP:0005389	7.8	HNF1A, GH1, TNF, DLK1, TSHR, SYT7
13	liver/biliary system phenotype	MP:0005370	7.6	RETN, GCK, SERPINA6, LPIN1, NOS3, PDX1
14	immune system phenotype	MP:0005387	7.3	UCP2, PRL, SLC2A4, ADIPOQ, GAD2, GGT1
15	tumorigenesis	MP:0002006	7.2	TNF, TNFRSF1B, PPARGC1A, PPARG, ACE, HIF1A
16	adipose tissue phenotype	MP:0005375	6.8	RETN, SERPINE1, LPIN1, LPL, LMNA, LIPE
17	vision/eye phenotype	MP:0005391	6.7	TNF, TNFRSF1B, DLK1, PPARG, NOS3, HIF1A
18	muscle phenotype	MP:0005369	6.5	TCF7L2, SYT7, SOD1, SLC2A4, RRAD, ADIPOQ
19	growth/size phenotype	MP:0005378	6.2	GCK, GCG, BTC, SERPINE1, LPIN1, LPL
20	mortality/aging	MP:0010768	6.1	GYS1, IRS1, IRS2, INPP5D, INPPL1, GSK3B
21	cardiovascular system phenotype	MP:0005385	5.4	GYS1, IRS1, IRS2, INS, INSR, IL6
22	cellular phenotype	MP:0005384	5.1	SLC17A5, NEUROD1, NEUROG3, ADIPOQ, PIK3AP1, RBP4
23	behavior/neurological phenotype	MP:0005386	4.4	IL6, ACE, HIF1A, HFE, TSHR, TCF7L2
24	homeostasis/metabolism phenotype	MP:0005376	0.4	ABCC8, GAD2, GGT1, ADIPOQ, ADRB3, NEUROG3

Articles related to glucose intolerance:

(show top 50)    (show all 127)

id	Title	Authors	Year	Affiliating Genes
1	Glucose intolerance and decreased early insulin respo nse in mice with severe hypertriglyceridemia. (20404017)	Ding Y.L.... Yang J.K.	2010	LPL
2	Angiopoietin-2 levels in glucose intolerance, hyperte nsion, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiolog y Study-74). (19913849)	Anuradha S.... Dixit M.	2010	ANGPT2
3	Disruption of the dopamine d2 receptor impairs insuli n secretion and causes glucose intolerance. (20147524)	GarcA-a-TornadA_ I.... Becu-Villalobos D.	2010	INS
4	Adiponectin and carotid intimal medial thickness in s ubjects with and without glucose intolerance (CURES-82). (20105040)	Gokulakrishnan K.... Mohan V.	2010	ADIPOQ
5	Body iron stores and glucose intolerance in premenopa usal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism. (19401444)	MartA-nez-GarcA-a M.A.... Escobar-Morreale H.F.	2009	TNF, IL6, TNFRSF1B
6	Abnormalities in glucose homeostasis in acromegaly. Does the prevalence of glucose intolerance depend on the level of activity of the disease and the duration of the symptoms? (19224501)	Stelmachowska-BanaA9 M.... ZgliczyA8ski W.	2009	INS, GH1
7	Impact of adiponectin and ghrelin on incident glucose intolerance and on weight change. (18624998)	Bennett N.R.... Forrester T.E.	2009	ADIPOQ, GHRL
8	A 52-week, randomized, open-label, parallel-group comparison of the tolerability and effects of pitavastatin and atorvastatin on high-density lipoprotein cholesterol levels and glucose metabolism in Japanese patients with elevated levels of low-density lipoprotein cholesterol and glucose intolerance. (18640465)	Sasaki J.... Kono S.	2008	APOA1, GPT
9	A cross-sectional study of the association between pe rsistent organic pollutants and glucose intolerance among Greenland Inuit. (18560802)	JA... Bjerregaard P.	2008	INS
10	Association of high sensitivity C-reactive protein [hsCRP] and tumour necrosis factor-alpha [TNF-alpha] with carotid intimal medial thickness in subjects with different grades of glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURES-31). (18328265)	Gokulakrishnan K.... Mohan V.	2008	TNF, CRP
11	Metabolic characteristics of glucose intolerance: the critical role of obesity. (17972239)	Sainaghi P.P.... Bartoli E.	2008	INS
12	Glucose intolerance and diabetes are observed in the long-term follow-up of nonpancreatectomized patients with persistent hyperinsulinemic hypoglycemia of infancy due to mutations in the ABCC8 gene. (18339976)	Gussinyer M.... Carrascosa A.	2008	ABCC8
13	Early-phase insulin secretion is disturbed in obese s ubjects with glucose intolerance. (17512320)	Mizuno A.... Doi T.	2007	INS
14	Neonatal streptozotocin-induced glucose intolerance: different consequences in Lyon normotensive and hypertensive rats. (17211251)	Emonnot L.... Lo M.	2007	ST3GAL4
15	Hypoadiponectinemia is associated with insulin resistance and glucose intolerance after renal transplantation: impact of immunosuppressive and antihypertensive drug therapy. (17699261)	Hjelmesaeth J.... Hartmann A.	2006	ADIPOQ
16	Increased plasma levels of thioredoxin in patients wi th glucose intolerance. (16357448)	Miyamoto S.... Ogawa H.	2005	TXN
17	Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy. (15807714)	Andersen O.... Madsbad S.	2005	GCG
18	Discrepancies in the regulation of plasma adiponectin and TNF-alpha levels and adipose tissue gene expression in obese African Americans with glucose intolerance: a pilot study using rosiglitazone. (16259488)	Osei K.... Schuster D.	2005	TNF, ADIPOQ
19	Serum levels of soluble tumor necrosis factor-alpha receptor 2 are linked to insulin resistance and glucose intolerance in children. (15679072)	Gupta A.... Anhalt H.	2005	INS
20	Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter. (15375789)	Pearce N.J.... Holder J.C.	2004	GSK3B, IRS1
21	Reversal of glucose intolerance by by pioglitazone in high fat diet-fed rats. (15319810)	Srinivasan K.... Ramarao P.	2004	INS
22	Plasma selenium decrease during pregnancy is associated with glucose intolerance. (15258316)	Hawkes W.C.... King J.C.	2004	GPX3
23	Glucose intolerance and serum aminotransferase activities in Japanese men. (12480555)	Miyake Y.... Kono S.	2003	GGT1, GPT, GOT1
24	Sleep-disordered breathing, glucose intolerance, and insulin resistance. (12853008)	Punjabi N.M.... O'Donnell C.P.	2003	INS
25	Glucose intolerance in obese children: a preliminary study (12870237)	Barja S.... Arteaga A.	2003	INS
26	Autoantibodies to pancreatic hsp60 precede the development of glucose intolerance in patients with cystic fibrosis. (11591125)	Jensen P.... Cohen I.R.	2001	HSPD1
27	Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance. (10868969)	Crossey P.A.... Miell J.P.	2000	IGFBP1
28	Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene. (10884287)	Reue K.... Slavin B.G.	2000	FASN, LPL, INS
29	Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance. (10960722)	MacNamara C.M.... Turner R.C.	2000	INS
30	Association of HELLP syndrome with autoimmune antibodies and glucose intolerance. (10840997)	Weitgasser R.... Sandhofer F.	2000	TPO, TSHR
31	Glucose intolerance is predicted by low insulin secre tion and high glucagon secretion: outcome of a prospective study in postmenopau sal Caucasian women. (10753041)	Larsson H.... AhrAcn B.	2000	INS
32	Relationship of the angiotensin-converting enzyme gene polymorphism to glucose intolerance, insulin resistance, and hypertension in NIDDM. (9544854)	Huang X.H.... Lehtimaki T.	1998	ACE, INS
33	Association of the Trp64Arg mutation of the beta3-adrenergic receptor with fatty liver and mild glucose intolerance in Japanese subjects. (9694585)	Shima Y.... Ohta H.	1998	ADRB3
34	Effect of acarbose on glucose intolerance in patients with non-insulin-dependent diabetes mellitus. (9279483)	Noda K.... Nawata H.	1997	INS
35	The postprandial state: mechanisms of glucose intolerance. (9272609)	Dinneen S.F.	1997	INS
36	Effects of heparin-induced non-esterified free fatty acid on minimal model-derived insulin sensitivity in individuals with varying degrees of glucose intolerance. (8846683)	Osei K.... Schuster D.P.	1995	INS
37	Changes in carnitine metabolism with ketone body prod uction in obese glucose-intolerant patients. (8745200)	Inokuchi T.... Isogai S.	1995	INS
38	Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: influence on muscle glycogen synthase and insulin receptor kinase activity. (8786726)	Breum L.... Astrup A.	1995	APC, GYS1
39	Relations between deletion polymorphism of the angiotensin-converting enzyme gene and insulin resistance, glucose intolerance, hyperinsulinemia, and dyslipidemia. (7773733)	Katsuya T.... Reaven G.M.	1995	ACE, APOB
40	Roles of insulin resistance and beta-cell dysfunction in the pathogenesis of glucose intolerance in cystic fibrosis. (8027259)	Austin A.... Arslanian S.	1994	INS
41	Insulin resistance, glucose intolerance, and hyperinsulinemia. Hypertriglyceridemia versus hypercholesterolemia. (8443140)	Sheu W.H.... Reaven G.M.	1993	SST
42	Hypokalemia, glucose intolerance, and hyperinsulinemi a during diuretic therapy. (1735589)	Plavinik F.L.... Ribeiro A.B.	1992	INS
43	Insulin resistance and endogenous digoxin-like factor in obese hypertensive patients with glucose intolerance. (1315588)	Andronico G.... Bompiani G.D.	1992	INS
44	Insulin and glucose levels and prevalence of glucose intolerance in pedigrees with multiple diabetic siblings. (1860554)	Elbein S.C.... Schumacher M.C.	1991	INS
45	Screening for insulin receptor gene DNA polymorphisms associated with glucose intolerance in a Scandinavian population. (1676686)	Sten-Linder M.... Luthman H.	1991	INSR
46	Hypertension in glucose intolerance and diabetes. (2043226)	Jarrett R.J.	1991	ALB
47	Abnormal glucagon response to arginine and its normalization in obese hyperinsulinaemic patients with glucose intolerance: importance of insulin action on pancreatic alpha cells. (1769438)	Hamaguchi T.... Shichiri M.	1991	INS
48	Hepatic dearterialisation induces glucose intolerance and inhibits insulin secretion in patients with liver malignancy. (1678646)	SjAPvall S.... AhrAcn B.	1991	INS
49	Association of fasting glucose levels with a delayed secretion of insulin after oral glucose in subjects with glucose intolerance. (2229300)	Bergstrom R.W.... Fujimoto W.Y.	1990	INS
50	A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance. (1251844)	Edwards J.A.... Frohman L.A.	1976	PIK3AP1

Genes related to glucose intolerance according to GeneCards:

(show top 50)    (show all 112)

id	Symbol	Description	Score	GeneCards Section Context
1	PAX4	paired box 4	11.0
2	CAPN10	calpain 10	11.0
3	PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	11.0
4	GYS1	glycogen synthase 1 (muscle)	11.0	Publications
5	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	11.0	Publications
6	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
7	PAX6	paired box 6	11.0	Publications
8	IAPP	islet amyloid polypeptide	11.0
9	INS	insulin	11.0	Publications
10	PDX1	pancreatic and duodenal homeobox 1	11.0
11	RBP4	retinol binding protein 4, plasma	11.0	Publications
12	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	11.0	Publications
13	GCG	glucagon	11.0	Publications
14	RETN	resistin	11.0	Publications
15	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
16	LIPE	lipase, hormone-sensitive	11.0
17	ADRB3	adrenoceptor beta 3	11.0	Publications
18	IRS2	insulin receptor substrate 2	11.0
19	NNT	nicotinamide nucleotide transhydrogenase	11.0
20	TTF2	transcription termination factor, RNA polymerase II	11.0
21	LPL	lipoprotein lipase	11.0	Publications
22	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
23	GCK	glucokinase (hexokinase 4)	11.0	Publications
24	LSL	Leptin, serum levels of	11.0	Publications
25	NPY	neuropeptide Y	11.0
26	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
27	INSR	insulin receptor	11.0	Publications
28	IDE	insulin-degrading enzyme	11.0
29	LEPR	leptin receptor	11.0	Publications
30	LMNA	lamin A/C	11.0
31	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	11.0
32	SHBG	sex hormone-binding globulin	11.0	Publications
33	DPP4	dipeptidyl-peptidase 4	11.0	Publications
34	SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	11.0
35	TXN	thioredoxin	11.0	Publications
36	COG2	component of oligomeric golgi complex 2	11.0
37	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
38	PPARA	peroxisome proliferator-activated receptor alpha	11.0
39	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
40	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0
41	GH1	growth hormone 1	11.0	Publications
42	GHR	growth hormone receptor	11.0
43	LEP	leptin	11.0	Publications
44	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
45	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0
46	RRAD	Ras-related associated with diabetes	11.0	Publications
47	LPIN3	lipin 3	11.0	Publications
48	PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	11.0	Publications
49	NEUROG3	neurogenin 3	11.0	Publications
50	INPPL1	inositol polyphosphate phosphatase-like 1	11.0	Publications

Pathways related to glucose intolerance according to GeneDecks:

(show top 50)    (show all 54)

id	Pathway	Score	Top Affiliating Genes
1	Aldosterone-regulated sodium reabsorption20	10.8	HSD11B1, INS, IRS2
2	Maturity onset diabetes of the young20	10.7	NEUROG3, NEUROD1, PDX1, HNF1A, IAPP, PAX6
3	PGC1Alpha Pathway36	10.6	SLC2A4, PPARA, PPARGC1A, TNFRSF1B, INSR
4	Type II diabetes mellitus20	10.6	ADIPOQ, SLC2A4, ABCC8, PDX1, INS, IRS2
5	Translation_Insulin regulation of translation41	10.5	INSR, INS, IRS2, IRS1
6	Development IGF-RI signaling10	10.5	IGF1, IGFBP3, IGFBP1, IRS1, GYS1
7	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	10.5	KCNJ11, IRS1, IRS2, INS, INSR, HNF1A
8	Growth Hormone Signaling36	10.5	SLC2A4, GHR, GH1, IGF1, IRS1
9	Adipocytokines & Insulin Signaling37	10.5	ADIPOQ, SLC2A4, GSK3B, INSR, INS, IRS2
10	Regulation of lipid metabolism Insulin signaling-generic cascades10	10.4	SLC2A4, GSK3B, INS, IRS2, IRS1, LIPE
11	PPAR signaling pathway20	10.4	ADIPOQ, PPARA, PPARG, APOC3, APOA1, CD36
12	Regulation of lipid metabolism_Insulin signaling-generic cascades41	10.4	IRS2, INS, INSR, GSK3B, SLC2A4, IRS1
13	Insulin Receptor Pathway36	10.4	SLC2A4, GSK3B, INSR, INS, IRS2, IRS1
14	Translation Regulation activity of EIF210	10.4	INSR, IRS2, IRS1
15	Development_Growth hormone signaling via PI3K/AKT and MAPK cascades41	10.3	GHR, GH1, GSK3B, IRS2, IRS1
16	Selected targets of C/EBPalpha10	10.3	RETN, CD36, APOB, ALB, ADIPOQ
17	Development Growth hormone signaling via PI3K/AKT and MAPK cascades10	10.3	GHR, GH1, GSK3B, IRS2, IRS1
18	Transcription_Receptor-mediated HIF regulation41	10.3	HIF1A, IGF1, IGFBP3, INSR, INS, IRS2
19	Transcription Receptor-mediated HIF regulation10	10.3	HIF1A, IRS1, IRS2, INS, INSR, IGFBP3
20	Development Leptin signaling via PI3K-dependent pathway10	10.3	SLC2A4, ABCC8, GSK3B, IRS2, IRS1, LEPR
21	Development_Leptin signaling via PI3K-dependent pathway41	10.2	LEPR, IRS1, IRS2, GSK3B, ABCC8, SLC2A4
22	AMPK Enzyme Complex Pathway36	10.2	SLC2A4, NOS3, FASN, INSR, INS, IRS2
23	Development_IGF-1 receptor signaling41	10.2	IGF1, IGFBP3, IGFBP1, GSK3B, IRS2, IRS1
24	Statin Pathway, Pharmacodynamics34	10.2	APOC3, APOB, APOA1, LPL
25	Translation Insulin regulation of translation10	10.1	GSK3B, IRS1
26	JNK Pathway36	10.1	ANGPT2, IL6R, IL6, IRS1, BTC
27	Insulin signaling pathway20	10.1	INSR, GSK3B, FASN, PPARGC1A, SLC2A4, INS
28	Selected targets of GCR-alpha10	10.1	NR3C1, GHR, HSPD1, IGFBP1, IL6, INSR
29	mTOR Pathway36	10.0	HIF1A, GH1, IGF1, IL6, INSR, INS
30	SOCS Pathway36	9.9	CCL2, ANGPT2, IL6, INSR, INS, IRS2
31	Neuroactive ligand-receptor interaction20	9.8	ADRB3, PRL, TSHR, NR3C1, GHR, GH1
32	Glucose / Energy Metabolism3	9.8	INSR, INS, IRS2, IRS1, GYS1, LIPE
33	ILK Signaling36	9.8	TCF7L2, HIF1A, GH1, IGF1, GSK3B, INSR
34	Selected targets of HNF110	9.8	DPP4, PDX1, UCP2, INS, APOA1, APOB
35	Translation _Regulation of EIF2 activity41	9.8	INSR, IRS2, IRS1, GSK3B
36	Metabolism of lipids and lipoproteins38	9.6	FASN, ALB, HSD11B1, PPARA, GGT1, APOC3
37	Adipocytokine signaling pathway20	9.6	ADIPOQ, PCK2, LEP, LEPR, SLC2A4, NPY
38	LDL Oxidation in Atherogenesis36	9.5	TNF, CCL2, CD36, VCAM1
39	Molecular Mechanisms of Cancer36	9.5	HIF1A, TNFRSF1B, GH1, ANGPT2, APC, IL6R
40	Jak-STAT signaling pathway20	9.5	PRL, TPO, GHR, GH1, IFNA1, IL6R
41	Activation of PKA through GPCR36	9.3	IGF1, GH1, CRP, NOS3, ADRB3, IL6
42	Activation of cAMP-Dependent PKA36	9.3	ADRB3, NOS3, CRP, GH1, IGF1, IL6
43	PPAR Pathway36	9.2	PPARA, PPARG, TNFRSF1B, TNF, GH1, IGF1
44	Type I diabetes mellitus20	9.1	GAD2, PTPRN, PTPRN2, TNF, HSPD1, INS
45	Malaria20	9.1	TNF, CCL2, IL6, CD36, VCAM1
46	Akt Signaling36	8.9	SLC2A4, TNF, CCL2, IL6R, IL6, GSK3B
47	JAK-STAT Pathway36	8.9	PRL, TNFRSF1B, GHR, GH1, IFNA1, IGF1
48	Metabolic pathways20	8.8	CAT, TPO, NOS3, NNT, ST3GAL4, PON1
49	Tec Kinases Signaling36	8.6	TNFRSF1B, TNF, GH1, IGF1, CCL2, ANGPT2
50	Cytokine-cytokine receptor interaction20	8.0	GHR, TPO, TNF, TNFRSF1B, PRL, GH1

Compounds related to glucose intolerance according to GeneDecks:

(show top 50)    (show all 451)

id	Compound	Score	Top Affiliating Genes
1	2-deoxyglucose32	10.7	GCK, LIPE, IRS1, INS, INSR, IGF1
2	glimepiride32 34 9 9	13.5	COG2, GCG, SERPINE1, KCNJ11, INS, INSR
3	isoproterenol32 9 9	12.3	GCG, LIPE, UCP2, INSR, APC, IAPP
4	gnrh32	10.3	GCG, SERPINE1, LEP, LEPR, INS, CCL2
5	dopamine32 9 18 9	13.2	GCG, RBP4, LEPR, UCP2, IRS1, INSR
6	carbohydrates32	10.1	SERPINA6, VCAM1, UCP2, APOC3, FASN, GHR
7	acipimox32	10.0	GCG, LIPE, LEP, INS, APOA1, APOB
8	sterol32	10.0	COG2, RETN, PCK2, GCK, LIPE, UCP2
9	palmitate32	9.9	GCG, UCP2, IRS1, APOA1, FASN, GHR
10	triacylglycerol32	9.9	COG2, PCK2, GCG, RBP4, SERPINE1, LPL
11	epinephrine32 9 18 9	12.9	GCG, LIPE, LEP, GYS1, INS, INSR
12	orlistat32 42 9 9	12.9	GCG, LPL, LEP, INS, APOB, FASN
13	ibmx32	9.9	PCK2, GCG, LPL, VCAM1, IRS1, INS
14	glutamate32	9.7	PCK2, GCK, GCG, KCNJ11, SCG5, CKM
15	telmisartan32 9 9	11.6	COG2, LEP, INS, ALB, PPARG, PPARA
16	ascorbic acid32 18	10.6	RBP4, CD36, GPX3, IGFBP3, TXN, TPO
17	glucose32	9.6	GCG, BTC, LPIN1, PAX4, PAX6, KCNJ11
18	fluvastatin32 34 9 9	12.4	COG2, SERPINE1, LPL, VCAM1, IL6, APOA1
19	progesterone32 42 9 18 9	13.3	GCK, BTC, RBP4, SERPINA6, LEPR, IRS2
20	h2o232	9.3	PCBD1, GCK, LEP, LEPR, UCP2, IRS1
21	pravastatin32 34 9 18 9	13.2	COG2, SERPINE1, IL6, APOA1, APOB, APOC3
22	glycogen32 18	10.1	RETN, PCK2, GCK, GCG, LIPE, CKM
23	pyruvate32	9.1	PCK2, GCK, LIPE, CKM, UCP2, MT-ND3
24	octreotide32 42 9 9	12.1	GCG, INS, INSR, IGFBP1, IGFBP3, IGF1
25	cysteine32	8.9	PCK2, GCK, GCG, RBP4, SERPINA6, SCG5
26	triiodothyronine32	8.9	COG2, PCK2, RBP4, SERPINA6, LEP, LEPR
27	adenylate32	8.8	GCK, GCG, RBP4, SERPINA6, SERPINE1, LPL
28	losartan32 34 9 9	11.8	SERPINE1, VCAM1, LEP, CD36, IRS1, CCL2
29	ribonucleic acid32	8.7	RBP4, SERPINA6, LIPE, LEPR, UCP2, IL6R
30	calcium32 9 18 9	11.6	COG2, RETN, GCK, BTC, RBP4, LMNA
31	acth32	8.6	SERPINA6, SCG5, LEP, LEPR, INS, IL6
32	vitamin-e32	8.6	COG2, RBP4, VCAM1, UCP2, APOC3, GPT
33	homocysteine32 18	9.4	COG2, RETN, SERPINE1, VCAM1, APOA1, APOB
34	sb 20358032 42	9.3	GCG, VCAM1, CD36, IRS1, INSR, IL6
35	hydrocortisone32 9 9	10.2	SERPINA6, CD36, INS, INSR, IL6, IGFBP1
36	vitamin d32	8.2	SERPINE1, LPL, SCG5, LEPR, CD36, INSR
37	alpha lipoic acid32	8.0	VCAM1, INS, INSR, CCL2, CAT, GHRL
38	vitamin a32 9 18 9	11.0	RETN, PCK2, RBP4, SERPINA6, LPL, LEP
39	simvastatin32 34 42 9 18 9	12.9	COG2, RBP4, SERPINE1, LPL, VCAM1, IL6
40	atorvastatin32 34 9 18 9	11.8	COG2, RETN, SERPINE1, LPL, VCAM1, IL6
41	actinomycin d32	7.7	RETN, SERPINE1, IRS1, INSR, IL6, FASN
42	norepinephrine32 9 18 9	10.7	RETN, GCG, LPL, VCAM1, LIPE, LEP
43	uric acid32 18	8.6	RETN, RBP4, SERPINE1, LEP, INS, APOA1
44	glutamine32	7.5	PCK2, GCK, GCG, LPL, KCNJ11, SCG5
45	testosterone32 9 18 9	10.5	COG2, SERPINA6, LPL, VCAM1, SCG5, IRS1
46	rosiglitazone32 9 18 9	10.0	COG2, RETN, PCK2, RBP4, SERPINE1, LPL
47	fibrinogen32	6.6	COG2, RETN, SERPINE1, VCAM1, SCG5, LEP
48	lactate32	5.9	PCK2, GCK, GCG, RBP4, LPL, VCAM1
49	alanine32	5.5	COG2, RETN, PCK2, GCK, GCG, RBP4
50	cholesterol32 9 18 9	8.4	COG2, RETN, PCK2, GCK, RBP4, SERPINA6

Cellular components related to glucose intolerance according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	spherical high-density lipoprotein particle	GO:034366	10.0	APOA1, APOC3, PON1
2	very-low-density lipoprotein particle	GO:034361	9.9	APOC3, APOB, APOA1, LPL
3	secretory granule	GO:030141	9.5	PTPRN2, GHRL, HSPD1, APOA1, INS, SCG5
4	cell surface	GO:009986	8.8	DPP4, TNF, TPO, GHR, HSPD1, IDE
5	cytosol	GO:005829	7.3	TXN, CAT, CAPN10, HSPD1, GOT1, IDE
6	extracellular region	GO:005576	6.2	ADIPOQ, IGFBP1, CCL2, ANGPT2, APOC3, APOB
7	extracellular space	GO:005615	5.5	ADIPOQ, GCG, CCL2, ANGPT2, ENPP2, ENPP1
8	plasma membrane	GO:005886	5.3	NOS3, TNFRSF1B, TNF, TPO, GHR, GLP1R

Biological processes related to glucose intolerance according to GeneDecks:

(show top 50)    (show all 67)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of glucose import	GO:046326	10.8	ADIPOQ, CAPN10, IGF1, INSR, INS, IRS2
2	positive regulation of glycogen biosynthetic process	GO:045725	10.8	IGF1, INSR, INS, IRS2, IRS1, GCK
3	positive regulation of cell differentiation	GO:045597	10.7	NEUROD1, GHR, GLP1R, INS, PAX4
4	brown fat cell differentiation	GO:050873	10.7	ADIPOQ, ADRB3, SLC2A4, PPARG, PPARGC1A
5	positive regulation of glycolysis	GO:045821	10.6	HIF1A, IGF1, INSR, INS, GCK
6	positive regulation of fatty acid oxidation	GO:046321	10.6	PPARA, PPARG, PPARGC1A
7	positive regulation of insulin secretion	GO:032024	10.6	TCF7L2, GHRL, GLP1R, CAPN10, IRS2, RBP4
8	negative regulation of appetite	GO:032099	10.6	PPARA, LEP, GCG
9	response to insulin stimulus	GO:032868	10.6	NR3C1, PPARA, PTPRN, INPPL1, IRS1, LEP
10	glucocorticoid metabolic process	GO:008211	10.6	NR3C1, APOA1, SERPINA6
11	gluconeogenesis	GO:006094	10.5	PPARGC1A, GOT1, GPT, RBP4, PCK2
12	cellular response to insulin stimulus	GO:032869	10.5	GHR, PPARG, HIF1A, SLC2A4, ADIPOQ, CAPN10
13	triglyceride catabolic process	GO:019433	10.4	APOC3, APOB, LIPE, LPL
14	cholesterol metabolic process	GO:008203	10.4	CAT, APOC3, APOB, APOA1, LEPR, LEP
15	negative regulation of gluconeogenesis	GO:045721	10.4	INS, GCK, ADIPOQ
16	energy reserve metabolic process	GO:006112	10.4	ADRB3, ABCC8, GLP1R, FASN, INS, LEPR
17	endocrine pancreas development	GO:031018	10.3	NEUROG3, NEUROD1, PDX1, IAPP, IL6R, IL6
18	negative regulation of macrophage derived foam cell differentiation	GO:010745	10.3	ADIPOQ, CRP, PPARA, PPARG
19	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	10.2	GHR, GH1, IL6R, IL6, LEP
20	negative regulation of hydrolase activity	GO:051346	10.2	NOS3, APOA1, LEPR
21	response to glucose stimulus	GO:009749	10.2	ADIPOQ, NEUROD1, TCF7L2, HIF1A, PTPRN, GLP1R
22	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.2	PRL, GHR, GH1, IRS2, IRS1
23	lipoprotein metabolic process	GO:042157	10.2	PPARA, ALB, APOC3, APOB, APOA1, LPL
24	glucose homeostasis	GO:042593	10.2	ADIPOQ, GCK, RBP4, SERPINE1, NEUROD1, SLC2A4
25	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.2	ADIPOQ, GHR, GH1, IGF1, IL6R, IL6
26	exocrine pancreas development	GO:031017	10.1	PDX1, IGF1, INSR
27	fatty acid metabolic process	GO:006631	10.1	PPARA, GHR, FASN, LPIN3, LPIN2
28	lipid metabolic process	GO:006629	10.0	PPARA, PPARG, ALB, APOC3, APOB, APOA1
29	positive regulation of MAPK cascade	GO:043410	10.0	ADRB3, IGF1, IGFBP3, IL6R, IL6, INSR
30	G-protein coupled receptor signaling pathway	GO:007186	9.9	TSHR, SST, GHRL, CCL2, ENPP2, APOC3
31	positive regulation of cell proliferation	GO:008284	9.9	DPP4, TSHR, PDX1, GLP1R, IGF1, IL6R
32	glucose metabolic process	GO:006006	9.9	GOT1, GHRL, TNF, PDX1, ADIPOQ, INS
33	response to ethanol	GO:045471	9.8	ADIPOQ, SLC2A4, SOD1, NOS3, CCL2, INSR
34	response to activity	GO:014823	9.7	NR3C1, TNF, CCL2, ANGPT2, INSR
35	regulation of insulin secretion	GO:050796	9.7	NEUROD1, ABCC8, TNF, GLP1R, INS, LEP
36	response to glucocorticoid stimulus	GO:051384	9.4	ADIPOQ, TNF, GHR, GOT1, CCL2, IL6
37	platelet degranulation	GO:002576	9.3	SOD1, ALB, IGF1, APOA1, CD36, SERPINE1
38	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.3	NEUROG3, NEUROD1, PPARG, PPARGC1A, TNF, IL6
39	organ morphogenesis	GO:009887	9.3	PDX1, TNF, CCL2, GSK3B, PAX6, PAX4
40	positive regulation of chemokine production	GO:032722	9.2	IL6, IL6R, TNF, HIF1A
41	positive regulation of smooth muscle cell proliferation	GO:048661	9.2	HIF1A, TNF, IGF1, IL6R, IL6
42	positive regulation of interleukin-6 production	GO:032755	9.1	TNF, HSPD1, IL6R, IL6, CD36
43	negative regulation of lipid storage	GO:010888	8.9	CRP, TNF, IL6
44	response to hypoxia	GO:001666	8.6	CRP, NOS3, HIF1A, DPP4, ADIPOQ, PPARA
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	PPARG, PPARA, PDX1, HIF1A, TCF7L2, NEUROD1
46	anti-apoptosis	GO:006916	8.3	SOD1, TCF7L2, NOS3, NR3C1, TNF, GHRL
47	positive regulation of apoptotic process	GO:043065	8.3	NEUROD1, SOD1, NOS3, TNF, CAPN10, HSPD1
48	negative regulation of apoptotic process	GO:043066	8.2	HSPD1, CAT, GLP1R, GHRL, TNF, NEUROD1
49	small molecule metabolic process	GO:044281	8.1	GGT1, SLC2A4, ST3GAL4, ABCC8, NNT, NOS3
50	response to drug	GO:042493	8.1	TNF, SST, PPARG, NOS3, SOD1, NEUROD1

Molecular functions related to glucose intolerance according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin receptor binding	GO:005158	10.4	IGF1, ENPP1, INS, IRS2, IRS1
2	SH2 domain binding	GO:042169	10.3	IRS1, INPPL1, INSR, GHR
3	insulin-like growth factor receptor binding	GO:005159	10.3	IGF1, INSR, INS, IRS1
4	receptor binding	GO:005102	10.1	CAT, DPP4, NPY, ADIPOQ, IAPP, IDE
5	hormone activity	GO:005179	9.7	ADIPOQ, PRL, TTR, SST, GH1, IAPP
6	protein kinase binding	GO:019901	9.2	TCF7L2, HIF1A, GHR, APC, GSK3B, IRS2
7	protein homodimerization activity	GO:042803	8.8	SHBG, DPP4, SOD1, PON1, ADRB3, ADIPOQ
8	protein binding	GO:005515	3.7	GGT1, NOS3, CRP, NR3C1, PPARA, PPARG