MCID: GLC009
MIFTS: 25

Glucosephosphate Dehydrogenase Deficiency malady

Aliases & Classifications for Glucosephosphate Dehydrogenase Deficiency

About this section

Glucosephosphate Dehydrogenase Deficiency, Aliases & Descriptions:

Name: Glucosephosphate Dehydrogenase Deficiency 9 11
Deficiency of Glucose-6-Phosphate Dehydrogenase 60
 
Glucose-6-Phosphate Dehydrogenase Deficiency 9
Deficiency of G-6pd 9


External Ids:

Disease Ontology9 DOID:2862
MeSH33 D005955

Summaries for Glucosephosphate Dehydrogenase Deficiency

About this section


Disease Ontology:9 A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated g6pd or g6pdh).

MalaCards based summary: Glucosephosphate Dehydrogenase Deficiency, also known as deficiency of glucose-6-phosphate dehydrogenase, is related to hemolytic anemia and malaria. An important gene associated with Glucosephosphate Dehydrogenase Deficiency is PKLR (pyruvate kinase, liver and RBC), and among its related pathways are Carbon metabolism and Sulfation Biotransformation Reaction. The compounds 23-diphosphoglycerate and zinc protoporphyrin have been mentioned in the context of this disorder.

Related Diseases for Glucosephosphate Dehydrogenase Deficiency

About this section

Diseases related to Glucosephosphate Dehydrogenase Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia31.9PKLR
2malaria31.1HP, G6PD
3favism31.1HP, G6PD
4sickle cell disease30.9G6PD, HP
5pyruvate kinase deficiency30.8PKLR, G6PD
6blackwater fever30.8G6PD
7congenital nonspherocytic hemolytic anemia30.7PKLR, G6PD
8sickle cell anemia30.7G6PD, HP
9methemoglobinemia30.6GSR, HP, G6PD
10cataract30.6GSR, G6PD
11hemoglobinopathy30.5HP, G6PD
12hepatitis c30.5HP, GSR
13glucose-6-phosphate dehydrogenase deficiency30.5G6PD, HP
14senile cataract30.4G6PD, GSR
15autoimmune hemolytic anemia30.3HPR, HP, G6PD
16tuberculosis30.2HP, HPR, GSR
17congenital hemolytic anemia30.1PKLR, HP, G6PD
18neonatal jaundice10.9
19hepatitis10.8
20thalassemia10.7
21kernicterus10.7
22hepatitis a10.6
23viral hepatitis10.6
24gilbert syndrome10.5
25priapism10.5
26retinitis10.5
27retinal vein occlusion10.4
28diabetic ketoacidosis10.4
29cerebritis10.4
30pneumonia10.4
31sideroblastic anemia10.4
32spotted fever10.4
33toxoplasmosis10.4
34chediak-higashi syndrome10.2
35crigler-najjar syndrome, type ii10.2
36galactosemia10.2
37lysinuric protein intolerance10.2
38glutathione synthetase deficiency10.2
39lung cancer10.2
40congenital methemoglobinemia10.2
41chronic granulomatous disease10.2
42dengue hemorrhagic fever10.2
43ectodermal dysplasia10.2
44hematopoietic stem cell transplantation10.2
45hepatitis b10.2
46osteoarthritis10.2
47pulmonary tuberculosis10.2
48congenital adrenal hyperplasia10.2
49central retinal vein occlusion10.2
50hereditary spherocytosis10.2

Graphical network of the top 20 diseases related to Glucosephosphate Dehydrogenase Deficiency:



Diseases related to glucosephosphate dehydrogenase deficiency

Symptoms for Glucosephosphate Dehydrogenase Deficiency

About this section

Drugs & Therapeutics for Glucosephosphate Dehydrogenase Deficiency

About this section

Drug clinical trials:

Search ClinicalTrials for Glucosephosphate Dehydrogenase Deficiency

Search NIH Clinical Center for Glucosephosphate Dehydrogenase Deficiency

Genetic Tests for Glucosephosphate Dehydrogenase Deficiency

About this section

Anatomical Context for Glucosephosphate Dehydrogenase Deficiency

About this section

Animal Models for Glucosephosphate Dehydrogenase Deficiency or affiliated genes

About this section

Publications for Glucosephosphate Dehydrogenase Deficiency

About this section

Variations for Glucosephosphate Dehydrogenase Deficiency

About this section

Expression for genes affiliated with Glucosephosphate Dehydrogenase Deficiency

About this section
Search GEO for disease gene expression data for Glucosephosphate Dehydrogenase Deficiency.

Pathways for genes affiliated with Glucosephosphate Dehydrogenase Deficiency

About this section

Pathways related to Glucosephosphate Dehydrogenase Deficiency according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.5PKLR, G6PD
29.3GSR, G6PD
3
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
9.3GSR, G6PD
4
Show member pathways
9.2HPR, HP
5
Show member pathways
8.4DECR1, G6PD, PKLR, GSR

Compounds for genes affiliated with Glucosephosphate Dehydrogenase Deficiency

About this section
Sources:
43Novoseek, 28IUPHAR, 49PharmGKB, 12DrugBank, 2BitterDB, 24HMDB
See all sources

Compounds related to Glucosephosphate Dehydrogenase Deficiency according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate439.9HP, G6PD
2zinc protoporphyrin439.9HP, G6PD
3starch439.8HP, G6PD
4cellulose acetate439.8HP, G6PD
5sulfasalazine28 43 49 1212.8G6PD, HP
6o-ethylhydroxylamine439.8GSR, G6PD
7no-dimethylhydroxylamine439.8GSR, G6PD
8cumene hydroperoxide439.8GSR, G6PD
92,5-adp439.8GSR, G6PD
10dehydroascorbic acid43 1210.7GSR, G6PD
11diamide439.7G6PD, GSR
126-phosphogluconate439.7GSR, G6PD
13acetone439.7G6PD, GSR
14tert-butylhydroperoxide439.7GSR, G6PD
15alpha-ketoglutarate439.7G6PD, PKLR
16nadp+439.7GSR, G6PD
17gssg439.6G6PD, GSR
18methimazole43 2 1211.6GSR, G6PD
19alpha lipoic acid439.6G6PD, GSR
20ribavirin43 49 1211.6G6PD, HP
21guanidine hydrochloride439.3GSR, G6PD
22thiobarbituric acid439.3GSR, HP, G6PD
23tocopherol439.3G6PD, HP, GSR
24malondialdehyde439.3G6PD, HP, GSR
25glyceraldehyde 3-phosphate439.3G6PD, PKLR, GSR
26uric acid43 2410.3GSR, HP, G6PD
27chloroquine43 2 49 28 1213.3G6PD, HP, GSR
28vitamin-e439.3GSR, HP, G6PD
29glucose 6-phosphate43 2410.3GSR, HP, G6PD
30thyroxine43 2410.3GSR, HP, G6PD
31folate439.3GSR, HP, G6PD
32epinephrine43 24 1211.3G6PD, HP, GSR
33phosphoenolpyruvate43 1210.2PKLR, HPR
34ascorbic acid43 2410.2GSR, HP, G6PD
35NADP249.2DECR1, G6PD, GSR
36carbohydrates439.2HP, HPR, PKLR
37vitamin b12439.2HP, G6PD
38lactose43 1210.1HPR, HP, G6PD
39lactate439.1GSR, HP, G6PD
40creatinine439.1GSR, HP, G6PD
41nadph43 2410.1GSR, G6PD, DECR1
42aspartate439.1G6PD, HP, GSR
432-deoxyglucose43 1210.0G6PD, HPR
44fructose-1,6-bisphosphate439.0GSR, HPR, G6PD
45atp43 289.6PKLR, HPR, HP, G6PD
46glucose438.6G6PD, HP, HPR, PKLR
47adenylate438.5G6PD, HP, HPR, GSR
48estrogen438.4GSR, HPR, HP, G6PD
49serine438.4PKLR, HPR, HP, G6PD
50lipid438.3GSR, HPR, HP, G6PD

GO Terms for genes affiliated with Glucosephosphate Dehydrogenase Deficiency

About this section

Cellular components related to Glucosephosphate Dehydrogenase Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.2HPR, HP
2extracellular vesicular exosomeGO:00700628.2GSR, PKLR, HP, G6PD

Biological processes related to Glucosephosphate Dehydrogenase Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione metabolic processGO:00067499.0GSR, G6PD
2small molecule metabolic processGO:00442818.4GSR, PKLR, G6PD, DECR1

Molecular functions related to Glucosephosphate Dehydrogenase Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1catalytic activityGO:00038249.2HPR, HP
2hemoglobin bindingGO:00304929.1HPR, HP
3NADP bindingGO:00506619.0GSR, G6PD

Products for genes affiliated with Glucosephosphate Dehydrogenase Deficiency

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Glucosephosphate Dehydrogenase Deficiency

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet