Glucosephosphate Dehydrogenase Deficiency malady

NIH Rare Diseases: Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly. G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.³⁰

MalaCards: Glucosephosphate Dehydrogenase Deficiency, also known as g6pd deficiency, is related to hemolytic anemia and color blindness. An important gene associated with Glucosephosphate Dehydrogenase Deficiency is LY6G6D (lymphocyte antigen 6 complex, locus G6D), and among its related pathways are Pentose Phosphate Pathway (Erythrocyte) and Glutathione metabolism. The compounds 6-phosphogluconolactone and 6-aminonicotinamide have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lung and t cells.

Disease Ontology: A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated g6pd or g6pdh).⁶

Genetics Home Reference: Glucose-6-phosphate dehydrogenase deficiency is a genetic disorder that occurs most often in males. This condition mainly affects red blood cells, which carry oxygen from the lungs to tissues throughout the body. In affected individuals, a defect in an enzyme called glucose-6-phosphate dehydrogenase causes red blood cells to break down prematurely. This destruction of red blood cells is called hemolysis.¹⁷

Wikipedia: Glucose-6-phosphate dehydrogenase deficiency is an X-linked recessive hereditary disease characterised...⁴⁴ more...

Aliases & Descriptions:

glucosephosphate dehydrogenase deficiency 6 8 43 g6pd deficiency 7 44 30 16 17 33 32 glucose-6-phosphate dehydrogenase deficiency 6 30 16 17 deficiency of glucose-6-phosphate dehydrogenase 17 43

hemolytic anemia due to g6pd deficiency 30 deficiency of g-6pd 6 malnutrition 43 g6pdd 17

Diseases related to glucosephosphate dehydrogenase deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 384)

id	Related Disease	Score	Top Affiliating Genes
1	hemolytic anemia	33.3	PGD, G6PD
2	color blindness	29.6	XG, G6PD
3	hyperlipoproteinemia type iii	12.2	PGD, G6PD
4	rheumatic fever	12.1	G6PD, PGD
5	cutaneous leishmaniasis	12.1	PGD, G6PD
6	urethritis	12.0	PGD, G6PD
7	leishmaniasis	12.0	PGD, G6PD
8	cervical intraepithelial neoplasia	11.7	PGD, G6PD
9	jaundice	11.2
10	malaria	11.0
11	anemia	10.9
12	hepatitis	10.9
13	neonatal jaundice	10.7
14	gilbert syndrome	10.1
15	thalassemia	10.1
16	sickle cell disease	10.0
17	kernicterus	10.0
18	hepatitis a	9.8
19	cataract	9.5
20	viral hepatitis	9.5
21	methemoglobinemia	9.2
22	protein-energy malnutrition	8.9
23	beta thalassemia	8.9
24	sickle cell anemia	8.9
25	priapism	8.3
26	pyruvate kinase deficiency	8.3
27	retinal vein occlusion	8.3
28	retinitis	8.3
29	autoimmune hemolytic anemia	8.3
30	cholesterol	8.3
31	cerebritis	8.3
32	cerebral malaria	8.3
33	diabetic ketoacidosis	8.3
34	diabetes mellitus	8.3
35	hemoglobinopathy	8.3
36	hepatitis c	8.3
37	hepatitis e	8.3
38	hemolytic anemia due to g6pd deficiency	8.2
39	coronary heart disease	7.4
40	spherocytosis	7.4
41	cytomegalovirus infection	7.4
42	sepsis	7.4
43	hepatitis b	7.4
44	syncope	7.4
45	hereditary spherocytosis	7.4
46	toxoplasmosis	7.4
47	acute pancreatitis	7.4
48	lung cancer	7.4
49	typhoid fever	7.4
50	alpha thalassemia	7.4

Approved drugs:

Drug clinical trials:

Genetic tests related to glucosephosphate dehydrogenase deficiency:

id	Genetic test	Affiliating Genes
1	Glucosephosphate Dehydrogenase Deficiency clinical/research	G6PD

MalaCards organs/tissues related to glucosephosphate dehydrogenase deficiency:

²²

Genes related to glucosephosphate dehydrogenase deficiency according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	LY6G6D	lymphocyte antigen 6 complex, locus G6D	11.0
2	PGD	phosphogluconate dehydrogenase	11.0
3	G6PD	glucose-6-phosphate dehydrogenase	11.0
4	XG	Xg blood group	11.0	Disorders

Pathways related to glucosephosphate dehydrogenase deficiency according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Pentose Phosphate Pathway (Erythrocyte)34	9.0	G6PD, PGD
2	Glutathione metabolism20	9.0	G6PD, PGD
3	Pentose phosphate pathway20	8.9	G6PD, PGD
4	Metabolism38	8.7	G6PD, PGD

Compounds related to glucosephosphate dehydrogenase deficiency according to GeneDecks:

(show all 21)

id	Compound	Score	Top Affiliating Genes
1	6-phosphogluconolactone32	9.4	G6PD, PGD
2	6-aminonicotinamide32	9.4	G6PD, PGD
3	3alpha-hydroxysteroid32	9.4	PGD, G6PD
4	dehydroascorbic acid32	9.4	G6PD, PGD
5	prpp32	9.3	G6PD, PGD
6	6-phosphogluconate32	9.3	PGD, G6PD
7	nadp+32	9.3	G6PD, PGD
8	gssg32	9.3	G6PD, PGD
9	cellulose acetate32	9.3	PGD, G6PD
10	isocitrate32	9.3	G6PD, PGD
11	phenol32 18	10.3	PGD, G6PD
12	hypoxanthine32 9 18 9	12.3	G6PD, PGD
13	glycerol 3-phosphate32 18	10.2	G6PD, PGD
14	malate32	9.2	PGD, G6PD
15	malondialdehyde32	9.2	G6PD, PGD
16	glucose 6-phosphate32 18	10.1	PGD, G6PD
17	nad+32	9.1	G6PD, PGD
18	citrate32	9.0	G6PD, PGD
19	ascorbic acid32 18	10.0	G6PD, PGD
20	glyceraldehyde 3-phosphate32	8.9	PGD, G6PD
21	pyruvate32	8.7	G6PD, PGD

Biological processes related to glucosephosphate dehydrogenase deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	pentose biosynthetic process	GO:019322	9.0	G6PD, PGD
2	oxidation-reduction process	GO:055114	9.0	G6PD, PGD
3	pentose-phosphate shunt, oxidative branch	GO:009051	8.9	G6PD, PGD
4	pentose-phosphate shunt	GO:006098	8.7	G6PD, PGD

Molecular functions related to glucosephosphate dehydrogenase deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	NADP binding	GO:050661	9.0	G6PD, PGD