MCID: GBL002
MIFTS: 37

Goblet Cell Carcinoid

Categories: Rare diseases, Cancer diseases, Gastrointestinal diseases, Endocrine diseases

Aliases & Classifications for Goblet Cell Carcinoid

MalaCards integrated aliases for Goblet Cell Carcinoid:

Name: Goblet Cell Carcinoid 49 55
Goblet Cell Adenocarcinoid 49 55
Goblet Cell Carcinoma 49 55
Goblet Cell Tumor 49 55
Gcc 49 55
Carcinoid, Goblet Cell 69
Carcinoid Goblet Cell 51
Mucinous Carcinoid 49

Characteristics:

Orphanet epidemiological data:

55
goblet cell carcinoma
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

Classifications:



External Ids:

Orphanet 55 ORPHA329984
UMLS via Orphanet 70 C0205695
ICD10 via Orphanet 33 C18.1
UMLS 69 C0205695

Summaries for Goblet Cell Carcinoid

NIH Rare Diseases : 49 Goblet cell carcinoid (GCC) is a rare tumor normally occurring in the appendix which displays features of both a neuroendocrine tumor and a more aggressive form of cancer known as an adenocarcinoma. It is usually diagnosed in people over the age of 50. People with this tumor may develop acute appendicitis, abdominal pain, and diarrhea. Prognosis largely depends on the size of the tumor and whether it has spread to other parts of the body. Treatment involves surgery to remove the tumor. Depending on how much the tumor has spread, surgeons may remove the appendix, part of the colon, or the ovaries (in women). Some people will have chemotherapy after surgery. Last updated: 8/17/2016

MalaCards based summary : Goblet Cell Carcinoid, also known as goblet cell adenocarcinoid, is related to cystadenoma and carcinoid tumors, intestinal. An important gene associated with Goblet Cell Carcinoid is CDH1 (Cadherin 1), and among its related pathways/superpathways are WNT Signaling and Arf6 trafficking events. Affiliated tissues include appendix, ovary and colon.

Wikipedia : 72 The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine... more...

Related Diseases for Goblet Cell Carcinoid

Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 cystadenoma 30.6 CHGA KRT20
2 carcinoid tumors, intestinal 30.3 CHGA ENO2
3 neuroendocrine tumor 29.0 CHGA ENO2 GAST KRT20
4 glassy cell carcinoma of the cervix 10.9
5 adenocarcinoma 10.4
6 vaginal benign neoplasm 10.4 CHGA KRT20
7 ovarian large-cell neuroendocrine carcinoma 10.4 CHGA KRT20
8 vaginal adenoma 10.4 CHGA KRT20
9 vaginal tubulovillous adenoma 10.4 CHGA KRT20
10 adenoma of the pancreas 10.4 CHGA KRT20
11 linitis plastica 10.4 CDH1 KRT20
12 adenoid squamous cell carcinoma 10.4 CDH1 KRT20
13 morpheaform basal cell carcinoma 10.4 CDH1 KRT20
14 gastric diffuse adenocarcinoma 10.4 CDH1 KRT20
15 dermoid cyst 10.4 CHGA KRT20
16 tubular adenocarcinoma 10.4 CDH1 CHGA
17 infiltrative basal cell carcinoma 10.3 CDH1 KRT20
18 cecum adenocarcinoma 10.3 CHGA KRT20
19 urinary bladder small cell neuroendocrine carcinoma 10.3 CHGA ENO2
20 intracranial primitive neuroectodermal tumor 10.3 CHGA ENO2
21 auditory system cancer 10.3 CHGA ENO2
22 gallbladder small cell carcinoma 10.3 CHGA ENO2
23 epithelioid malignant peripheral nerve sheath tumor 10.3 CHGA ENO2
24 pulmonary large cell neuroendocrine carcinoma 10.3 CHGA ENO2
25 atypical follicular adenoma 10.3 CHGA ENO2
26 acute thyroiditis 10.3 CHGA ENO2
27 olfactory nerve neoplasm 10.3 CHGA ENO2
28 cauda equina neoplasm 10.3 CHGA ENO2
29 nodular ganglioneuroblastoma 10.3 CHGA ENO2
30 respiratory system benign neoplasm 10.3 CHGA ENO2
31 subependymoma 10.3 CHGA ENO2
32 malignant epithelial mesothelioma 10.3 CDH1 KRT20
33 pineocytoma 10.3 CHGA ENO2
34 pulmonary sclerosing hemangioma 10.3 CHGA CTNNB1
35 extrahepatic bile duct adenocarcinoma 10.3 CDH1 ENO2
36 gastric squamous cell carcinoma 10.3 CHGA ENO2
37 gastric small cell carcinoma 10.3 CHGA ENO2
38 small cell neuroendocrine carcinoma 10.3 CHGA ENO2
39 somatostatinoma 10.3 CHGA ENO2
40 papillary ependymoma 10.3 CHGA ENO2
41 cranial nerve malignant neoplasm 10.3 CHGA ENO2
42 spinal canal and spinal cord meningioma 10.3 CHGA ENO2
43 lung acinar adenocarcinoma 10.3 CTNNB1 KRT20
44 central neurocytoma 10.3 CHGA ENO2
45 carcinoid syndrome 10.3 CHGA ENO2
46 mature teratoma of the ovary 10.3 ENO2 KRT20
47 microcystic meningioma 10.3 CDH1 ENO2
48 cervix small cell carcinoma 10.3 CHGA ENO2
49 chondroid chordoma 10.3 CDH1 ENO2
50 spinal meningioma 10.3 CHGA ENO2

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to Goblet Cell Carcinoid

Symptoms & Phenotypes for Goblet Cell Carcinoid

Drugs & Therapeutics for Goblet Cell Carcinoid

Search Clinical Trials , NIH Clinical Center for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

Anatomical Context for Goblet Cell Carcinoid

MalaCards organs/tissues related to Goblet Cell Carcinoid:

38
Appendix, Ovary, Colon, Lung, Lymph Node

Publications for Goblet Cell Carcinoid

Articles related to Goblet Cell Carcinoid:

(show top 50) (show all 88)
# Title Authors Year
1
Goblet cell carcinoid of the appendix - An interobserver variability study using two proposed classification systems. ( 29414399 )
2018
2
Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix. ( 29327707 )
2018
3
Adenocarcinoma Ex Goblet Cell Carcinoid of Appendix: Two Case Reports. ( 28890838 )
2017
4
Intestinal goblet cell carcinoid presenting with recurrent sterile peritonitis in a patient on peritoneal dialysis: a case report. ( 28193185 )
2017
5
Goblet cell carcinoid of the appendix and mixed adenoneuroendocrine carcinoma: Report of three cases. ( 28808504 )
2017
6
Adenocarcinoma Ex-goblet Cell Carcinoid of the Appendix: a Case Report and Overview of the Disease. ( 28211016 )
2017
7
Amyand's hernia containing an appendiceal goblet cell carcinoid tumour. ( 28302663 )
2017
8
Adenocarcinoma Ex-Goblet Cell Carcinoid of the Appendix With Metastatic Peritoneal Spread to Meckel's Diverticulum and Endometriosis. ( 28449607 )
2017
9
Appendiceal goblet cell carcinoid: common errors in staging and clinical interpretation with a proposal for an improved terminology. ( 28551326 )
2017
10
A Study of Appendiceal Crypt Cell Adenocarcinoma (So-Called Goblet Cell Carcinoid and Its Related Adenocarcinoma). ( 28823572 )
2017
11
Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1. ( 27237132 )
2016
12
Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. ( 27338636 )
2016
13
Synchronous sessile serrated adenoma and goblet cell carcinoid in the appendix: A case report and literature review. ( 27773125 )
2016
14
Goblet-cell carcinoid of the ovary: A case report with ultrastructural analysis. ( 27922277 )
2016
15
A rare combination of ovarian and uterine leiomyomas with goblet cell carcinoid of the appendix. ( 25685587 )
2015
16
Goblet cell carcinoid tumor, mixed goblet cell carcinoid-adenocarcinoma, and adenocarcinoma of the appendix: comparison of clinicopathologic features and prognosis. ( 26030247 )
2015
17
Simplified 2-tier histologic grading system accurately predicts outcomes in goblet cell carcinoid of the appendix. ( 26433702 )
2015
18
Peritoneal metastatic goblet-cell carcinoid tumor treated with cytoreductive surgery and intraperitoneal chemotherapy. ( 25960976 )
2015
19
Late recurrence and metastasis of an appendiceal goblet cell carcinoid 24 years after appendectomy. ( 24451973 )
2014
20
Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: a case report with review of literature. ( 24739849 )
2014
21
Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory? ( 24943968 )
2014
22
EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix. ( 24560515 )
2014
23
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. ( 23088880 )
2013
24
Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature. ( 23564828 )
2013
25
Goblet cell carcinoid tumor of the appendix. ( 24224299 )
2013
26
Goblet cell carcinoid of appendix: A rare case with literature review. ( 23416502 )
2013
27
Goblet cell carcinoid in ascitic fluid. ( 22550034 )
2013
28
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. ( 23833405 )
2013
29
Appendiceal goblet cell carcinoid and mucinous neoplasms are closely associated tumors: Lessons from their coexistence in primary tumors and concurrence in peritoneal dissemination. ( 24374723 )
2013
30
Goblet cell carcinoid of the vermiform appendix - a case report. ( 23359204 )
2012
31
Serotonin- and somatostatin-positive goblet cell carcinoid of the duodenum. ( 22918208 )
2012
32
Goblet cell carcinoid and mucinous cystadenoma in an interval appendectomy specimen. ( 22273311 )
2012
33
Schistosomiasis may contribute to goblet cell carcinoid of the appendix. ( 22746391 )
2012
34
Appendiceal goblet cell carcinoid tumour: a case of unexpected lung metastasis. ( 22933998 )
2012
35
Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination. ( 23304574 )
2012
36
The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix. ( 21824598 )
2011
37
Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. ( 20640606 )
2011
38
Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. ( 21874432 )
2011
39
Goblet cell carcinoid tumor: a rare cause of appendicitis. ( 21396295 )
2011
40
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. ( 22107115 )
2011
41
Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). ( 21753706 )
2011
42
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. ( 22176273 )
2011
43
Cervical and endometrial metastases of appendiceal goblet cell carcinoid. ( 20441511 )
2010
44
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. ( 20732910 )
2010
45
Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. ( 20139759 )
2010
46
Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. ( 20631606 )
2010
47
Goblet cell carcinoid tumors of the appendix: An overview. ( 21160637 )
2010
48
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. ( 19471156 )
2009
49
Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix. ( 19610147 )
2009
50
Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? ( 18807600 )
2008

Variations for Goblet Cell Carcinoid

Cosmic variations for Goblet Cell Carcinoid:

9 (show all 46)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM11582 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 4
2 COSM10663 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 4
3 COSM11066 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 4
4 COSM10738 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 4
5 COSM11148 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 4
6 COSM10863 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.833C>T p.P278L 4
7 COSM43955 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.514G>A p.V172I 4
8 COSM10794 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.796G>A p.G266R 4
9 COSM14135 SMAD4 ovary,NS,carcinoma,adenocarcinoma c.1051G>C p.D351H 4
10 COSM14050 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1516G>A p.V506M 4
11 COSM14049 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1067C>T p.P356L 4
12 COSM766 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1636C>A p.Q546K 4
13 COSM564 NRAS ovary,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 4
14 COSM580 NRAS ovary,NS,carcinoma,adenocarcinoma c.181C>A p.Q61K 4
15 COSM522 KRAS ovary,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 4
16 COSM5352260 GNAS large intestine,appendix,carcinoma,adenocarcinoma c.679C>T p.Q227* 4
17 COSM53265 EGFR ovary,NS,carcinoma,adenocarcinoma c.2556G>T p.K852N 4
18 COSM22992 EGFR ovary,NS,carcinoma,adenocarcinoma c.2161G>A p.G721S 4
19 COSM53264 EGFR ovary,NS,carcinoma,adenocarcinoma c.2174C>T p.T725M 4
20 COSM53235 EGFR ovary,NS,carcinoma,adenocarcinoma c.2481C>T p.Y827Y 4
21 COSM53226 EGFR ovary,NS,carcinoma,adenocarcinoma c.2099A>G p.N700S 4
22 COSM28286 EGFR ovary,NS,carcinoma,adenocarcinoma c.2494C>T p.R832C 4
23 COSM53228 EGFR ovary,NS,carcinoma,adenocarcinoma c.2123A>G p.K708R 4
24 COSM53227 EGFR ovary,NS,carcinoma,adenocarcinoma c.2506C>A p.R836S 4
25 COSM6224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2573T>G p.L858R 4
26 COSM53230 EGFR ovary,NS,carcinoma,adenocarcinoma c.2597A>G p.E866G 4
27 COSM28511 EGFR ovary,NS,carcinoma,adenocarcinoma c.2108T>C p.L703P 4
28 COSM53225 EGFR ovary,NS,carcinoma,adenocarcinoma c.2112G>A p.L704L 4
29 COSM53232 EGFR ovary,NS,carcinoma,adenocarcinoma c.2122A>G p.K708E 4
30 COSM53266 EGFR ovary,NS,carcinoma,adenocarcinoma c.2165C>T p.A722V 4
31 COSM53224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2173A>G p.T725A 4
32 COSM53213 EGFR ovary,NS,carcinoma,adenocarcinoma c.2604A>T p.E868D 4
33 COSM53229 EGFR ovary,NS,carcinoma,adenocarcinoma c.2232C>A p.I744I 4
34 COSM53231 EGFR ovary,NS,carcinoma,adenocarcinoma c.2559C>T p.I853I 4
35 COSM12373 EGFR ovary,NS,carcinoma,adenocarcinoma c.2159C>T p.S720F 4
36 COSM22499 ATM ovary,NS,carcinoma,adenocarcinoma c.1810C>T p.P604S 4
37 COSM763 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3
38 COSM775 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3
39 COSM760 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3
40 COSM776 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.3140A>T p.H1047L 3
41 COSM520 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.35G>T p.G12V 3
42 COSM532 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.38G>A p.G13D 3
43 COSM521 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.35G>A p.G12D 3
44 COSM516 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>T p.G12C 3
45 COSM517 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>A p.G12S 3
46 COSM518 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>C p.G12R 3

Expression for Goblet Cell Carcinoid

Search GEO for disease gene expression data for Goblet Cell Carcinoid.

Pathways for Goblet Cell Carcinoid

GO Terms for Goblet Cell Carcinoid

Cellular components related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 9.26 CDH1 CTNNB1
2 apical junction complex GO:0043296 9.16 CDH1 CTNNB1
3 catenin complex GO:0016342 8.96 CDH1 CTNNB1
4 flotillin complex GO:0016600 8.62 CDH1 CTNNB1

Biological processes related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron death GO:1901215 9.26 CHGA CTNNB1
2 adherens junction organization GO:0034332 9.16 CDH1 CTNNB1
3 entry of bacterium into host cell GO:0035635 8.96 CDH1 CTNNB1
4 cellular response to indole-3-methanol GO:0071681 8.62 CDH1 CTNNB1

Sources for Goblet Cell Carcinoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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