MCID: GBL002
MIFTS: 29

Goblet Cell Carcinoid malady

Categories: Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Goblet Cell Carcinoid

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Sources:
46NIH Rare Diseases, 52Orphanet, 48Novoseek, 66UMLS, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Goblet Cell Carcinoid:

Name: Goblet Cell Carcinoid 46 52
Goblet Cell Adenocarcinoid 46 52
Goblet Cell Carcinoma 46 52
Goblet Cell Tumor 46 52
 
Gcc 46 52
Carcinoid, Goblet Cell 66
Carcinoid Goblet Cell 48
Mucinous Carcinoid 46

Characteristics:

Orphanet epidemiological data:

52
goblet cell adenocarcinoid:
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly

Classifications:



External Ids:

Orphanet52 ORPHA329984
ICD10 via Orphanet29 C18.1

Summaries for Goblet Cell Carcinoid

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NIH Rare Diseases:46 Goblet cell carcinoid (gcc) is a rare tumor normally occurring in the appendix which displays features of both a neuroendocrine tumor and a more aggressive form of cancer known as an adenocarcinoma. it is usually diagnosed in people over the age of 50. people with this tumor may develop acute appendicitis, abdominal pain, and diarrhea. prognosis largely depends on the size of the tumor and whether it has spread to other parts of the body. treatment involves surgery to remove the tumor. depending on how much the tumor has spread, surgeons may remove the appendix, part of the colon, or the ovaries (in women). some people will have chemotherapy after surgery. last updated: 8/17/2016

MalaCards based summary: Goblet Cell Carcinoid, also known as goblet cell adenocarcinoid, is related to glassy cell carcinoma of the cervix and itch e3 ubiquitin ligase deficiency. An important gene associated with Goblet Cell Carcinoid is CHGA (Chromogranin A). Affiliated tissues include appendix, colon and ovary.

Wikipedia:69 The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine... more...

Related Diseases for Goblet Cell Carcinoid

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Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1glassy cell carcinoma of the cervix11.0
2itch e3 ubiquitin ligase deficiency10.4CHGA, GAST
3spinal chordoma10.4CHGA, GAST
4extragonadal germ cell cancer10.4CHGA, GAST
5diabetes mellitus, transient neonatal, 310.4CHGA, GAST
6primary progressive multiple sclerosis10.4CHGA, GAST
7rectum signet ring adenocarcinoma10.4CHGA, GAST
8gastrointestinal anthrax10.4CHGA, GAST
9ureterocele10.4CDH1, CHGA
10glucosidase acid-1,4-alpha deficiency10.4CHGA, GAST
11pyloric antrum cancer10.4CDH1, GAST
12ferguson-smith tumor10.3CHGA, GAST
13adenocarcinoma10.3
14sensory system cancer10.3CHGA, KRT20
15pulmonary neuroendocrine tumor10.3CHGA, KRT20
16cellular phase chronic idiopathic myelofibrosis10.3CHGA, KRT20
17cerebellar vermis medulloblastoma10.3CDH1, CHGA
18steatitis10.3CDH1, KRT20
19adenoid basal cell carcinoma10.3CDH1, KRT20
20middle ear squamous cell carcinoma10.3CDH1, KRT20
21plethora of newborn10.3CDH1, KRT20
22intracortical osteogenic sarcoma10.3CHGA, GAST
23food allergy10.3CHGA, KRT20
24comedo carcinoma10.2CDH1, KRT20
25lateral sinus thrombosis10.2CDH1, KRT20
26peritonitis10.2
27vulva basal cell carcinoma10.2CDH1, KRT20
28caroli disease10.2CHGA, KRT20
29extrahepatic bile duct adenocarcinoma10.2CDH1, KRT20
30breast pericanalicular fibroadenoma10.2CHGA, KRT20
31persian gulf syndrome10.2CDH1, KRT20
32pemphigus vulgaris, familial10.2CEACAM7, KRT20
33gastrointestinal neuroendocrine tumor10.2CDH1, KRT20
34colorectal cancer10.2
35schistosomiasis10.1
36cystadenoma10.1
37esophagus small cell carcinoma10.1CHGA, ENO2
38restrictive cardiomyopathy10.1CHGA, KRT20
39mixed endometrial stromal and smooth muscle tumor10.1CHGA, ENO2
40norwegian scabies10.1CHGA, ENO2
41pilocytic astrocytoma10.1CHGA, ENO2
42peripheral nervous system ganglioneuroblastoma10.1CHGA, ENO2
43subpulmonary stenosis10.1CHGA, ENO2
44brain stem ependymoma10.1CHGA, ENO2
45pneumonia10.1CHGA, ENO2
46ovarian clear cell malignant adenofibroma10.1CHGA, ENO2
47gallbladder signet ring cell adenocarcinoma10.1CDH1, ENO2
48expressive language disorder10.1CHGA, ENO2
49xanthogranulomatous pyelonephritis10.1CHGA, ENO2
50urethral villous adenoma10.1CHGA, ENO2

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to goblet cell carcinoid

Symptoms for Goblet Cell Carcinoid

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Drugs & Therapeutics for Goblet Cell Carcinoid

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

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Anatomical Context for Goblet Cell Carcinoid

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MalaCards organs/tissues related to Goblet Cell Carcinoid:

34
Appendix, Colon, Ovary, Lung, Lymph node

Animal Models for Goblet Cell Carcinoid or affiliated genes

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Publications for Goblet Cell Carcinoid

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Articles related to Goblet Cell Carcinoid:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. (27338636)
2016
2
Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1. (27237132)
2016
3
Goblet cell carcinoid tumor, mixed goblet cell carcinoid-adenocarcinoma, and adenocarcinoma of the appendix: comparison of clinicopathologic features and prognosis. (26030247)
2015
4
Peritoneal metastatic goblet-cell carcinoid tumor treated with cytoreductive surgery and intraperitoneal chemotherapy. (25960976)
2015
5
Late recurrence and metastasis of an appendiceal goblet cell carcinoid 24 years after appendectomy. (24451973)
2014
6
Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory? (24943968)
2014
7
Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: a case report with review of literature. (24739849)
2014
8
EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix. (24560515)
2014
9
Goblet cell carcinoid of appendix: A rare case with literature review. (23416502)
2013
10
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. (23088880)
2013
11
Appendiceal goblet cell carcinoid and mucinous neoplasms are closely associated tumors: Lessons from their coexistence in primary tumors and concurrence in peritoneal dissemination. (24374723)
2013
12
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. (23833405)
2013
13
Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature. (23564828)
2013
14
Serotonin- and somatostatin-positive goblet cell carcinoid of the duodenum. (22918208)
2012
15
Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination. (23304574)
2012
16
Goblet cell carcinoid and mucinous cystadenoma in an interval appendectomy specimen. (22273311)
2012
17
Schistosomiasis may contribute to goblet cell carcinoid of the appendix. (22746391)
2012
18
Goblet cell carcinoid of the vermiform appendix - a case report. (23359204)
2012
19
Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. (21874432)
2011
20
Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). (21753706)
2011
21
Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. (20640606)
2011
22
Goblet cell carcinoid tumor: a rare cause of appendicitis. (21396295)
2011
23
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. (22107115)
2011
24
The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix. (21824598)
2011
25
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. (20732910)
2010
26
Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (20631606)
2010
27
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix. (18252007)
2008
28
Goblet cell carcinoid tumours of the appendix: a unique neuroendocrine tumour. (18439158)
2008
29
Goblet cell carcinoid of the appendix: a specific type of carcinoma. (18042066)
2007
30
Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. (16485156)
2006
31
Management of goblet cell carcinoid. (16967437)
2006
32
Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature. (16773013)
2006
33
Goblet cell carcinoid of the appendix. (15967038)
2005
34
Goblet cell carcinoid of the appendix. (16013634)
2005
35
Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). (16136284)
2005
36
Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors. (14681318)
2003
37
Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin. (11350611)
2001
38
Goblet cell carcinoid of the appendix endoscopically diagnosed and examined with p53 immunostaining. (9719248)
1998
39
Goblet cell carcinoid arising in a mature teratoma of the mediastinum. (8990147)
1997
40
Goblet cell carcinoid of the appendix. (7978019)
1994
41
Goblet cell carcinoid of the vermiform appendix with ovarian metastasis mimicking mucinous cystadenocarcinoma. (1950561)
1991
42
Goblet-cell carcinoid tumor in peritoneal fluid: a case report. (1648469)
1991
43
Goblet cell carcinoid of the appendix. (2370022)
1990
44
Adenocarcinoid (goblet cell carcinoid) of the duodenum presenting as gastric outlet obstruction. (2307453)
1990
45
Goblet cell carcinoid of the appendix. (2323597)
1990
46
Goblet cell carcinoid of the appendix. (2753618)
1989
47
Goblet cell carcinoid of the appendix. (7076213)
1982
48
Canine goblet-cell carcinoid. (7257086)
1981
49
Goblet cell carcinoid of appendix: ultrastructural features and histogenetic aspects. (498041)
1979
50
Appendico-vesical fistula due to an appendix abscess with associated goblet cell carcinoid of the appendix. (188508)
1976

Variations for Goblet Cell Carcinoid

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Cosmic variations for Goblet Cell Carcinoid:

8 (show all 38)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM532KRASgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.38G>Ap.G13D0
2COSM53225EGFRovary,NS,carcinoma,adenocarcinomac.2112G>Ap.L704L0
3COSM763PIK3CAgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.1633G>Ap.E545K0
4COSM516KRASgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.34G>Tp.G12C0
5COSM760PIK3CAgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.1624G>Ap.E542K0
6COSM521KRASgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.35G>Ap.G12D0
7COSM28511EGFRovary,NS,carcinoma,adenocarcinomac.2108T>Cp.L703P0
8COSM775PIK3CAgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.3140A>Gp.H1047R0
9COSM520KRASgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.35G>Tp.G12V0
10COSM53213EGFRovary,NS,carcinoma,adenocarcinomac.2604A>Tp.E868D0
11COSM53226EGFRovary,NS,carcinoma,adenocarcinomac.2099A>Gp.N700S0
12COSM53224EGFRovary,NS,carcinoma,adenocarcinomac.2173A>Gp.T725A0
13COSM53266EGFRovary,NS,carcinoma,adenocarcinomac.2165C>Tp.A722V0
14COSM53230EGFRovary,NS,carcinoma,adenocarcinomac.2597A>Gp.E866G0
15COSM53231EGFRovary,NS,carcinoma,adenocarcinomac.2559C>Tp.I853I0
16COSM6224EGFRovary,NS,carcinoma,adenocarcinomac.2573T>Gp.L858R0
17COSM53227EGFRovary,NS,carcinoma,adenocarcinomac.2506C>Ap.R836S0
18COSM776PIK3CAgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.3140A>Tp.H1047L0
19COSM53235EGFRovary,NS,carcinoma,adenocarcinomac.2481C>Tp.Y827Y0
20COSM22992EGFRovary,NS,carcinoma,adenocarcinomac.2161G>Ap.G721S0
21COSM28286EGFRovary,NS,carcinoma,adenocarcinomac.2494C>Tp.R832C0
22COSM517KRASgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.34G>Ap.G12S0
23COSM12373EGFRovary,NS,carcinoma,adenocarcinomac.2159C>Tp.S720F0
24COSM53265EGFRovary,NS,carcinoma,adenocarcinomac.2556G>Tp.K852N0
25COSM53264EGFRovary,NS,carcinoma,adenocarcinomac.2174C>Tp.T725M0
26COSM53228EGFRovary,NS,carcinoma,adenocarcinomac.2123A>Gp.K708R0
27COSM53232EGFRovary,NS,carcinoma,adenocarcinomac.2122A>Gp.K708E0
28COSM518KRASgastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinomac.34G>Cp.G12R0
29COSM53229EGFRovary,NS,carcinoma,adenocarcinomac.2232C>Ap.I744I0
30COSM27887GNASlarge intestine,appendix,carcinoma,adenocarcinomac.601C>Tp.R201C0
31COSM27895GNASlarge intestine,appendix,carcinoma,adenocarcinomac.602G>Ap.R201H0
32COSM10863TP53large intestine,appendix,carcinoma,adenocarcinomac.833C>Tp.P278L0
33COSM10794TP53large intestine,appendix,carcinoma,adenocarcinomac.796G>Ap.G266R0
34COSM27899GNASlarge intestine,appendix,carcinoma,adenocarcinomac.601C>Ap.R201S0
35COSM5352260GNASlarge intestine,appendix,carcinoma,adenocarcinomac.679C>Tp.Q227*0
36COSM43955TP53large intestine,appendix,carcinoma,adenocarcinomac.514G>Ap.V172I0
37COSM14049SMAD4large intestine,appendix,carcinoma,adenocarcinomac.1067C>Tp.P356L0
38COSM14050SMAD4large intestine,appendix,carcinoma,adenocarcinomac.1516G>Ap.V506M0

Expression for genes affiliated with Goblet Cell Carcinoid

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Search GEO for disease gene expression data for Goblet Cell Carcinoid.

Pathways for genes affiliated with Goblet Cell Carcinoid

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GO Terms for genes affiliated with Goblet Cell Carcinoid

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Sources for Goblet Cell Carcinoid

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet