GCC
MCID: GBL002
MIFTS: 34

Goblet Cell Carcinoid (GCC) malady

Categories: Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Goblet Cell Carcinoid

Aliases & Descriptions for Goblet Cell Carcinoid:

Name: Goblet Cell Carcinoid 50 56
Goblet Cell Adenocarcinoid 50 56
Goblet Cell Carcinoma 50 56
Goblet Cell Tumor 50 56
Gcc 50 56
Carcinoid, Goblet Cell 69
Carcinoid Goblet Cell 52
Mucinous Carcinoid 50

Characteristics:

Orphanet epidemiological data:

56
goblet cell carcinoma
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

Classifications:



External Ids:

Orphanet 56 ORPHA329984
ICD10 via Orphanet 34 C18.1

Summaries for Goblet Cell Carcinoid

NIH Rare Diseases : 50 goblet cell carcinoid (gcc) is a rare tumor normally occurring in the appendix which displays features of both a neuroendocrine tumor and a more aggressive form of cancer known as an adenocarcinoma. it is usually diagnosed in people over the age of 50. people with this tumor may develop acute appendicitis, abdominal pain, and diarrhea. prognosis largely depends on the size of the tumor and whether it has spread to other parts of the body. treatment involves surgery to remove the tumor. depending on how much the tumor has spread, surgeons may remove the appendix, part of the colon, or the ovaries (in women). some people will have chemotherapy after surgery. last updated: 8/17/2016

MalaCards based summary : Goblet Cell Carcinoid, also known as goblet cell adenocarcinoid, is related to glassy cell carcinoma of the cervix and peritoneal benign neoplasm. An important gene associated with Goblet Cell Carcinoid is CDH1 (Cadherin 1), and among its related pathways/superpathways are WNT Signaling and Arf6 trafficking events. Affiliated tissues include appendix, ovary and colon.

Wikipedia : 71 The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine... more...

Related Diseases for Goblet Cell Carcinoid

Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
id Related Disease Score Top Affiliating Genes
1 glassy cell carcinoma of the cervix 10.8
2 peritoneal benign neoplasm 10.2 CHGA KRT20
3 non specific chronic endometritis 10.2 CHGA KRT20
4 dystonia 10.2 CHGA KRT20
5 anal canal paget's disease 10.2 CHGA KRT20
6 gastritis 10.2 CDH1 KRT20
7 ovarian squamous cell carcinoma 10.2 CDH1 KRT20
8 infiltrative basal cell carcinoma 10.2 CDH1 KRT20
9 familial renal oncocytoma 10.2 CDH1 KRT20
10 mesenchymoma 10.2 CHGA KRT20
11 thymus small cell carcinoma 10.2 CHGA ENO2
12 sclerosing hemangioma 10.2 CDH1 CHGA
13 sm-ahnmd 10.2 CHGA ENO2
14 prolactin producing pituitary tumor 10.2 CHGA ENO2
15 adenocarcinoma 10.2
16 embryonal testis carcinoma 10.2 CDH1 KRT20
17 perineural angioma 10.2 CHGA ENO2
18 churg-strauss syndrome 10.2 CHGA KRT20
19 gliofibroma 10.2 CHGA ENO2
20 parietal lobe neoplasm 10.2 CHGA ENO2
21 urinary tract obstruction 10.2 CHGA ENO2
22 cavernous hemangioma of face 10.2 CHGA CTNNB1
23 superior vena cava syndrome 10.2 CHGA ENO2
24 spinal stenosis 10.2 CHGA ENO2
25 gastrointestinal system benign neoplasm 10.2 CHGA ENO2
26 fragile x-associated tremor/ataxia syndrome 10.2 CHGA ENO2
27 piussan lenaerts mathieu syndrome 10.2 CHGA ENO2
28 ampullary signet ring cell adenocarcinoma 10.2 CDH1 ENO2
29 anal squamous cell carcinoma 10.2 CHGA ENO2
30 uterine corpus myxoid leiomyosarcoma 10.2 CHGA ENO2
31 pancreatic agenesis 10.2 CHGA KRT20
32 bone marrow cancer 10.2 CHGA CTNNB1
33 pediculus humanus corporis infestation 10.2 CHGA ENO2
34 ampulla of vater mucinous adenocarcinoma 10.2 CHGA ENO2
35 substance abuse 10.2 CDH1 CTNNB1
36 sarcomatoid basal cell carcinoma 10.2 CDH1 KRT20
37 autoimmune pancreatitis 10.2 CHGA GAST
38 growth retardation hydrocephaly lung hypoplasia 10.2 CHGA ENO2
39 maxillary neoplasm 10.2 CDH1 ENO2
40 secondary syphilis 10.2 CHGA GAST
41 brain edema 10.2 CHGA GAST
42 adult myxoid chondrosarcoma 10.2 CTNNB1 KRT20
43 cardioauditory syndrome of sanchez cascos 10.2 CHGA ENO2
44 differentiating neuroblastoma 10.2 CDH1 ENO2
45 chromophil adenoma of the kidney 10.2 ENO2 KRT20
46 gastric duplication cysts 10.2 CHGA GAST
47 nemaline myopathy 8, autosomal recessive 10.2 CDH1 CTNNB1
48 volkmann contracture 10.2 CHGA GAST
49 diphtheria 10.2 CHGA ENO2
50 submucosal invasive colon adenocarcinoma 10.2 CHGA CTNNB1

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to Goblet Cell Carcinoid

Symptoms & Phenotypes for Goblet Cell Carcinoid

Drugs & Therapeutics for Goblet Cell Carcinoid

Search Clinical Trials , NIH Clinical Center for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

Anatomical Context for Goblet Cell Carcinoid

MalaCards organs/tissues related to Goblet Cell Carcinoid:

39
Appendix, Ovary, Colon, Lung, Lymph Node

Publications for Goblet Cell Carcinoid

Articles related to Goblet Cell Carcinoid:

(show top 50) (show all 78)
id Title Authors Year
1
Synchronous sessile serrated adenoma and goblet cell carcinoid in the appendix: A case report and literature review. ( 27773125 )
2016
2
Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. ( 27338636 )
2016
3
Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1. ( 27237132 )
2016
4
Goblet-cell carcinoid of the ovary: A case report with ultrastructural analysis. ( 27922277 )
2016
5
Peritoneal metastatic goblet-cell carcinoid tumor treated with cytoreductive surgery and intraperitoneal chemotherapy. ( 25960976 )
2015
6
Simplified 2-tier histologic grading system accurately predicts outcomes in goblet cell carcinoid of the appendix. ( 26433702 )
2015
7
A rare combination of ovarian and uterine leiomyomas with goblet cell carcinoid of the appendix. ( 25685587 )
2015
8
Goblet cell carcinoid tumor, mixed goblet cell carcinoid-adenocarcinoma, and adenocarcinoma of the appendix: comparison of clinicopathologic features and prognosis. ( 26030247 )
2015
9
EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix. ( 24560515 )
2014
10
Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: a case report with review of literature. ( 24739849 )
2014
11
Late recurrence and metastasis of an appendiceal goblet cell carcinoid 24 years after appendectomy. ( 24451973 )
2014
12
Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory? ( 24943968 )
2014
13
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. ( 23833405 )
2013
14
Goblet cell carcinoid of appendix: A rare case with literature review. ( 23416502 )
2013
15
Appendiceal goblet cell carcinoid and mucinous neoplasms are closely associated tumors: Lessons from their coexistence in primary tumors and concurrence in peritoneal dissemination. ( 24374723 )
2013
16
Goblet cell carcinoid tumor of the appendix. ( 24224299 )
2013
17
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. ( 23088880 )
2013
18
Goblet cell carcinoid in ascitic fluid. ( 22550034 )
2013
19
Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature. ( 23564828 )
2013
20
Goblet cell carcinoid of the vermiform appendix - a case report. ( 23359204 )
2012
21
Schistosomiasis may contribute to goblet cell carcinoid of the appendix. ( 22746391 )
2012
22
Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination. ( 23304574 )
2012
23
Goblet cell carcinoid and mucinous cystadenoma in an interval appendectomy specimen. ( 22273311 )
2012
24
Serotonin- and somatostatin-positive goblet cell carcinoid of the duodenum. ( 22918208 )
2012
25
Appendiceal goblet cell carcinoid tumour: a case of unexpected lung metastasis. ( 22933998 )
2012
26
The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix. ( 21824598 )
2011
27
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. ( 22176273 )
2011
28
Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. ( 20640606 )
2011
29
Goblet cell carcinoid tumor: a rare cause of appendicitis. ( 21396295 )
2011
30
Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). ( 21753706 )
2011
31
Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. ( 21874432 )
2011
32
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. ( 22107115 )
2011
33
Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. ( 20139759 )
2010
34
Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. ( 20631606 )
2010
35
Goblet cell carcinoid tumors of the appendix: An overview. ( 21160637 )
2010
36
Cervical and endometrial metastases of appendiceal goblet cell carcinoid. ( 20441511 )
2010
37
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. ( 20732910 )
2010
38
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. ( 19471156 )
2009
39
Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix. ( 19610147 )
2009
40
Laparoscopic right hemicolectomy for goblet-cell carcinoid of the appendix: report of a rare case and literature survey. ( 18503377 )
2008
41
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. ( 18685490 )
2008
42
Cytology of metastatic appendiceal goblet cell carcinoid in pleural effusion fluid: a case report. ( 18855885 )
2008
43
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix. ( 18252007 )
2008
44
Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? ( 18807600 )
2008
45
Goblet cell carcinoid tumours of the appendix: a unique neuroendocrine tumour. ( 18439158 )
2008
46
Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix. ( 17049463 )
2007
47
Goblet cell carcinoid tumors (adenocarcinoid) of the appendix. ( 17195086 )
2007
48
Goblet cell carcinoid of the appendix: a specific type of carcinoma. ( 18042066 )
2007
49
Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. ( 16485156 )
2006
50
Laparoscopic two-stage surgery for goblet cell carcinoid of the appendix: report of a case and review of the Japanese literature. ( 16773013 )
2006

Variations for Goblet Cell Carcinoid

Cosmic variations for Goblet Cell Carcinoid:

9 (show all 35)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10863 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.833C>T p.P278L 4
2 COSM10794 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.796G>A p.G266R 4
3 COSM43955 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.514G>A p.V172I 4
4 COSM14049 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1067C>T p.P356L 4
5 COSM14050 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1516G>A p.V506M 4
6 COSM5352260 GNAS large intestine,appendix,carcinoma,adenocarcinoma c.679C>T p.Q227* 4
7 COSM28511 EGFR ovary,NS,carcinoma,adenocarcinoma c.2108T>C p.L703P 4
8 COSM12373 EGFR ovary,NS,carcinoma,adenocarcinoma c.2159C>T p.S720F 4
9 COSM53235 EGFR ovary,NS,carcinoma,adenocarcinoma c.2481C>T p.Y827Y 4
10 COSM53224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2173A>G p.T725A 4
11 COSM22992 EGFR ovary,NS,carcinoma,adenocarcinoma c.2161G>A p.G721S 4
12 COSM28286 EGFR ovary,NS,carcinoma,adenocarcinoma c.2494C>T p.R832C 4
13 COSM53225 EGFR ovary,NS,carcinoma,adenocarcinoma c.2112G>A p.L704L 4
14 COSM6224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2573T>G p.L858R 4
15 COSM53228 EGFR ovary,NS,carcinoma,adenocarcinoma c.2123A>G p.K708R 4
16 COSM53232 EGFR ovary,NS,carcinoma,adenocarcinoma c.2122A>G p.K708E 4
17 COSM53266 EGFR ovary,NS,carcinoma,adenocarcinoma c.2165C>T p.A722V 4
18 COSM53229 EGFR ovary,NS,carcinoma,adenocarcinoma c.2232C>A p.I744I 4
19 COSM53213 EGFR ovary,NS,carcinoma,adenocarcinoma c.2604A>T p.E868D 4
20 COSM53231 EGFR ovary,NS,carcinoma,adenocarcinoma c.2559C>T p.I853I 4
21 COSM53230 EGFR ovary,NS,carcinoma,adenocarcinoma c.2597A>G p.E866G 4
22 COSM53265 EGFR ovary,NS,carcinoma,adenocarcinoma c.2556G>T p.K852N 4
23 COSM53226 EGFR ovary,NS,carcinoma,adenocarcinoma c.2099A>G p.N700S 4
24 COSM53264 EGFR ovary,NS,carcinoma,adenocarcinoma c.2174C>T p.T725M 4
25 COSM53227 EGFR ovary,NS,carcinoma,adenocarcinoma c.2506C>A p.R836S 4
26 COSM775 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3
27 COSM763 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3
28 COSM760 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3
29 COSM776 PIK3CA gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.3140A>T p.H1047L 3
30 COSM521 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.35G>A p.G12D 3
31 COSM520 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.35G>T p.G12V 3
32 COSM532 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.38G>A p.G13D 3
33 COSM518 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>C p.G12R 3
34 COSM516 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>T p.G12C 3
35 COSM517 KRAS gastrointestinal tract (site indeterminate),NS,carcinoma,adenocarcinoma c.34G>A p.G12S 3

Expression for Goblet Cell Carcinoid

Search GEO for disease gene expression data for Goblet Cell Carcinoid.

Pathways for Goblet Cell Carcinoid

GO Terms for Goblet Cell Carcinoid

Cellular components related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 9.26 CDH1 CTNNB1
2 apical junction complex GO:0043296 9.16 CDH1 CTNNB1
3 catenin complex GO:0016342 8.96 CDH1 CTNNB1
4 flotillin complex GO:0016600 8.62 CDH1 CTNNB1

Biological processes related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron death GO:1901215 9.26 CHGA CTNNB1
2 adherens junction organization GO:0034332 9.16 CDH1 CTNNB1
3 entry of bacterium into host cell GO:0035635 8.96 CDH1 CTNNB1
4 cellular response to indole-3-methanol GO:0071681 8.62 CDH1 CTNNB1

Sources for Goblet Cell Carcinoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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