MCID: GBL002
MIFTS: 40

Goblet Cell Carcinoid malady

Categories: Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Goblet Cell Carcinoid

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Sources:
45NIH Rare Diseases, 51Orphanet, 47Novoseek, 65UMLS, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Goblet Cell Carcinoid:

Name: Goblet Cell Carcinoid 45 51
Goblet Cell Adenocarcinoid 45 51
Goblet Cell Carcinoma 45 51
Goblet Cell Tumor 45 51
 
Gcc 45 51
Carcinoid, Goblet Cell 65
Carcinoid Goblet Cell 47
Mucinous Carcinoid 45

Characteristics:

Orphanet epidemiological data:

51
goblet cell adenocarcinoid:
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly

Classifications:



External Ids:

Orphanet51 329984
ICD10 via Orphanet28 C18.1
UMLS65 C0205695

Summaries for Goblet Cell Carcinoid

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NIH Rare Diseases:45 Goblet cell carcinoid (gcc) is a rare neuroendocrine tumor that almost always occurs in the appendix. it is usually diagnosed in a person's 50's. people with this tumor may develop acute appendicitis, abdominal pain, and a lump. in about half of women, the tumor has already spread to the ovary by the time it is diagnosed. prognosis largely depends on the size of the tumor and whether it has spread to other parts of the body. about 76% of people with a gcc are alive five years after they are diagnosed. treatment involves surgery to remove the tumor. depending on how much the tumor has spread, surgeons may remove the appendix, part of the colon, or the ovaries in women. some people will have chemotherapy after surgery. last updated: 5/1/2015

MalaCards based summary: Goblet Cell Carcinoid, also known as goblet cell adenocarcinoid, is related to glassy cell carcinoma of the cervix and appendix lymphoma. An important gene associated with Goblet Cell Carcinoid is CDH1 (Cadherin 1), and among its related pathways are Adherens junction and EGFR Signaling Pathway. Affiliated tissues include appendix, colon and ovary, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Wikipedia:68 The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine... more...

Related Diseases for Goblet Cell Carcinoid

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Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1glassy cell carcinoma of the cervix11.0
2appendix lymphoma10.3CDH1, CTNNB1
3hilar lung neoplasm10.3CDH1, CTNNB1
4dermato-cardio-skeletal syndrome, borrone type10.3CDH1, CTNNB1
5developmental and speech delay due to sox5 deficiency10.3CDH1, CTNNB1
6adenocarcinoma10.3
7breast granular cell tumor10.3CDH1, CTNNB1
8bile duct signet ring cell carcinoma10.3CDH1, CHGA
9ovarian cancer, somatic10.3CDH1, CTNNB1
10nasal cavity adenocarcinoma10.3CDH1, CHGA
11biliary tract neoplasm10.3CDH1, CTNNB1
12oral tuberculosis10.3CDH1, CHGA
13charcot-marie-tooth disease10.2CDH1, CTNNB1
14vasculitis10.2CDH1, CTNNB1
15colon mucinous adenocarcinoma10.2CHGA, CTNNB1
16large cell medulloblastoma10.2CDH1, CHGA
17pyometritis10.2CDH1, CTNNB1
18tracheal lymphoma10.2CDH1, CTNNB1
19hypothalamic disease10.2CDH1, CTNNB1
20pancreatic somatostatinoma10.2CDH1, CTNNB1
21photosensitive epilepsy10.2CHGA, CTNNB1
22tubular adenocarcinoma10.2CDH1, CTNNB1
23spermatogenic failure 1310.2CDH1, CTNNB1
24organ system benign neoplasm10.2CHGA, CTNNB1
25colorectal cancer10.2
26schistosomiasis10.1
27cystadenoma10.1
28peritonitis10.1
29restless legs syndrome10.1CDH1, CTNNB1
30tenosynovitis of foot and ankle10.1CDH1, CTNNB1
31lipoma of the rectum10.1ATOH1, CHGA
32hepatocellular adenoma10.1CDH1, CTNNB1
33cervicomedullary junction neoplasm10.1ATOH1, CTNNB1
34breast neuroendocrine neoplasm10.1CDH1, CTNNB1
35mucinous adenocarcinoma10.1
36proctitis10.1CDH1, CTNNB1
37pylorus cancer10.0CDH1, GAST
38polyclonal hypergammaglobulinemia10.0CDH1, CTNNB1
39gastrointestinal system disease10.0CHGA, GAST
40spinal cord injury10.0CHGA, GAST
41secondary progressive multiple sclerosis10.0CHGA, GAST
42small intestine leiomyoma10.0CHGA, GAST
43megaloblastic anemia9.9CHGA, GAST
44lung giant cell carcinoma9.9CHGA, GAST
45gastric gastrinoma9.9CHGA, GAST
46colloid carcinoma of the pancreas9.9CHGA, GAST
47joint disorders9.9CHGA, GAST
48neurofibromatosis, type 19.9
49ileitis9.9
50leiomyoma9.9

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to goblet cell carcinoid

Symptoms for Goblet Cell Carcinoid

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Drugs & Therapeutics for Goblet Cell Carcinoid

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

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Anatomical Context for Goblet Cell Carcinoid

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MalaCards organs/tissues related to Goblet Cell Carcinoid:

33
Appendix, Colon, Ovary, Breast, Liver, Lung, Kidney

Animal Models for Goblet Cell Carcinoid or affiliated genes

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MGI Mouse Phenotypes related to Goblet Cell Carcinoid:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.8ATOH1, CDH1, CTNNB1, GAST
2MP:00053797.7ATOH1, CDH1, CHGA, CTNNB1, GAST
3MP:00053767.5ATOH1, CDH1, CHGA, CTNNB1, GAST

Publications for Goblet Cell Carcinoid

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Articles related to Goblet Cell Carcinoid:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Goblet cell carcinoid tumor, mixed goblet cell carcinoid-adenocarcinoma, and adenocarcinoma of the appendix: comparison of clinicopathologic features and prognosis. (26030247)
2015
2
Peritoneal metastatic goblet-cell carcinoid tumor treated with cytoreductive surgery and intraperitoneal chemotherapy. (25960976)
2015
3
EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix. (24560515)
2014
4
Late recurrence and metastasis of an appendiceal goblet cell carcinoid 24 years after appendectomy. (24451973)
2014
5
Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory? (24943968)
2014
6
Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: a case report with review of literature. (24739849)
2014
7
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. (23833405)
2013
8
Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature. (23564828)
2013
9
Goblet cell carcinoid of appendix: A rare case with literature review. (23416502)
2013
10
Goblet cell carcinoid in ascitic fluid. (22550034)
2013
11
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. (23088880)
2013
12
Serotonin- and somatostatin-positive goblet cell carcinoid of the duodenum. (22918208)
2012
13
Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination. (23304574)
2012
14
Goblet cell carcinoid and mucinous cystadenoma in an interval appendectomy specimen. (22273311)
2012
15
Schistosomiasis may contribute to goblet cell carcinoid of the appendix. (22746391)
2012
16
Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. (21874432)
2011
17
Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). (21753706)
2011
18
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. (22176273)
2011
19
Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. (20640606)
2011
20
Goblet cell carcinoid tumor: a rare cause of appendicitis. (21396295)
2011
21
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. (20732910)
2010
22
Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. (20139759)
2010
23
Cervical and endometrial metastases of appendiceal goblet cell carcinoid. (20441511)
2010
24
Goblet cell carcinoid tumors of the appendix: An overview. (21160637)
2010
25
Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix. (19610147)
2009
26
Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? (18807600)
2008
27
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix. (18252007)
2008
28
Goblet cell carcinoid of the appendix: a specific type of carcinoma. (18042066)
2007
29
Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix. (17049463)
2007
30
Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. (16485156)
2006
31
Goblet cell carcinoid of the appendix. (15967038)
2005
32
Goblet cell carcinoid of the appendix. (16013634)
2005
33
Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). (16136284)
2005
34
Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors. (14681318)
2003
35
Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin. (11350611)
2001
36
Goblet cell carcinoid of the appendix endoscopically diagnosed and examined with p53 immunostaining. (9719248)
1998
37
Goblet cell carcinoid of the appendix. (7978019)
1994
38
Goblet cell carcinoid of the appendix. (7949643)
1994
39
Goblet-cell carcinoid tumor in peritoneal fluid: a case report. (1648469)
1991
40
Goblet cell carcinoid of the vermiform appendix with ovarian metastasis mimicking mucinous cystadenocarcinoma. (1950561)
1991
41
Goblet cell carcinoid of the appendix. (2323597)
1990
42
Goblet cell carcinoid of the appendix. (2370022)
1990
43
Adenocarcinoid (goblet cell carcinoid) of the duodenum presenting as gastric outlet obstruction. (2307453)
1990
44
Goblet cell carcinoid of the appendix. (2753618)
1989
45
Goblet cell carcinoid tumour of the appendix. (6882644)
1983
46
Two cases of goblet cell carcinoid tumor of the appendix with bilateral ovarian metastases. (7113691)
1982
47
Canine goblet-cell carcinoid. (7257086)
1981
48
Goblet cell carcinoid of appendix: ultrastructural features and histogenetic aspects. (498041)
1979
49
Appendico-vesical fistula due to an appendix abscess with associated goblet cell carcinoid of the appendix. (188508)
1976
50
Goblet cell carcinoid of the appendix. An ultrastructural and histochemical study. (946758)
1976

Variations for Goblet Cell Carcinoid

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Expression for genes affiliated with Goblet Cell Carcinoid

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Search GEO for disease gene expression data for Goblet Cell Carcinoid.

Pathways for genes affiliated with Goblet Cell Carcinoid

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GO Terms for genes affiliated with Goblet Cell Carcinoid

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Biological processes related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:00716819.8CDH1, CTNNB1
2cellular response to lithium ionGO:00712859.8CDH1, CTNNB1
3negative regulation of neuron deathGO:19012159.6CHGA, CTNNB1
4neuron differentiationGO:00301829.2ATOH1, CTNNB1
5adherens junction organizationGO:00343329.1CDH1, CTNNB1
6neuron migrationGO:00017649.0ATOH1, CTNNB1

Sources for Goblet Cell Carcinoid

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet