GCC
MCID: GBL002
MIFTS: 47

Goblet Cell Carcinoid (GCC) malady

Rare diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Goblet Cell Carcinoid

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NIH Rare Diseases:42 Goblet cell carcinoid (gcc)is a rare type of neuroendocrine tumor that involves the appendix almost exclusively. it typically comes to attention in the fifth to sixth decade of life. signs and symptoms may include acute appendicitis, followed by abdominal pain and a mass. in about fifty percent of affected females, the tumor has metastasized to the ovary by the time of diagnosis. in general, approximately 76% of individuals with a gcc are alive five years after the diagnosis. prognosis largely depends on the stage of the disease (i.e. the size of the tumor and whether it has spread to other parts of the body). treatment often includes appendectomy and right hemicolectomy, followed by adjuvant chemotherapy in some cases. however, there is some debate about the extent of surgical treatment for these tumors. last updated: 6/25/2013

MalaCards based summary: Goblet Cell Carcinoid, also known as goblet cell carcinoma, is related to neuroendocrine tumor and adenocarcinoma. An important gene associated with Goblet Cell Carcinoid is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are CDC42 signaling events and Adhesion. The compounds lithium chloride and pepsinogen have been mentioned in the context of this disorder. Affiliated tissues include appendix, ovary and lymph node, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Wikipedia:65 The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine... more...

Aliases & Classifications for Goblet Cell Carcinoid

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Sources:
42NIH Rare Diseases, 44Novoseek, 48Orphanet, 62UMLS
See all sources

Goblet Cell Carcinoid, Aliases & Descriptions:

Name: Goblet Cell Carcinoid 42 48
Goblet Cell Carcinoma 42 48
Goblet Cell Adenocarcinoid 48
Carcinoid, Goblet Cell 62
 
Carcinoid Goblet Cell 44
Mucinous Carcinoid 42
Goblet Cell Tumor 48
Gcc 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
goblet cell carcinoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Related Diseases for Goblet Cell Carcinoid

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Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine tumor30.5GAST, CHGA
2adenocarcinoma29.9CHGA, CEACAM7, GAST, CDH1, CTNNB1
3colorectal cancer29.9CEACAM7, GAST, CDH1, CTNNB1
4cystadenoma10.5
5schistosomiasis10.5
6cerebellar liponeurocytoma10.5ATOH1
7merkel cell carcinoma10.4CHGA
8mucinous adenocarcinoma10.4
9peritonitis10.4
10pernicious anemia10.4GAST
11neurofibromatosis10.3
12ileitis10.3
13appendicitis10.3
14mucinous cystadenocarcinoma10.3
15cervicitis10.3
16cystadenocarcinoma10.3
17intestinal obstruction10.3
18mature teratoma10.3
19teratoma10.3
20gastric outlet obstruction10.3
21signet ring cell adenocarcinoma10.2CDH1, CHGA
22adenosquamous carcinoma10.2CHGA, CEACAM7
23large cell carcinoma10.2CHGA, CEACAM7
24hyperinsulinemic hypoglycemia10.2GAST, CHGA
25gastrointestinal carcinoma10.2CEACAM7, GAST
26pancreatic islet cell tumors10.2GAST, CHGA
27somatostatinoma10.2GAST, CHGA
28endocrine gland cancer10.2GAST, CHGA
29microinvasive gastric cancer10.2CDH1, GAST
30vipoma10.2GAST, CHGA
31zollinger-ellison syndrome10.1GAST, CHGA
32atrophic gastritis10.1CHGA, GAST
33glucagonoma10.1CHGA, GAST
34serotonin syndrome10.1CHGA, GAST
35stomach cancer10.1GAST, CDH1
36gastrinoma10.1CHGA, GAST
37primary hyperparathyroidism10.1CHGA, GAST
38multiple endocrine neoplasia10.1GAST, CHGA
39wermer syndrome10.1GAST, CHGA
40paraganglioma10.1GAST, CHGA
41hyperparathyroidism10.1CHGA, GAST
42papillary carcinoma10.1CDH1, CHGA
43thyroid medullary carcinoma10.1GAST, CHGA
44hypercalcemia10.1GAST, CHGA
45diarrhea10.1CHGA, GAST
46gastritis10.1GAST, CHGA
47cystic fibrosis10.0
48leukemia10.0
49chronic leukemia10.0
50germ cell cancer10.0

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to goblet cell carcinoid

Symptoms for Goblet Cell Carcinoid

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Drugs & Therapeutics for Goblet Cell Carcinoid

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Drug clinical trials:

Search ClinicalTrials for Goblet Cell Carcinoid

Search NIH Clinical Center for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

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Anatomical Context for Goblet Cell Carcinoid

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MalaCards organs/tissues related to Goblet Cell Carcinoid:

32
Appendix, Ovary, Lymph node, Lung

Animal Models for Goblet Cell Carcinoid or affiliated genes

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MGI Mouse Phenotypes related to Goblet Cell Carcinoid:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3ATOH1, GAST, CDH1, CTNNB1
2MP:00053797.9CTNNB1, CDH1, GAST, CHGA, ATOH1
3MP:00107687.9CTNNB1, CDH1, GAST, CHGA, ATOH1
4MP:00053767.6ATOH1, CHGA, GAST, CDH1, CTNNB1

Publications for Goblet Cell Carcinoid

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Articles related to Goblet Cell Carcinoid:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Late recurrence and metastasis of an appendiceal goblet cell carcinoid 24 years after appendectomy. (24451973)
2014
2
Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory? (24943968)
2014
3
Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: a case report with review of literature. (24739849)
2014
4
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. (23833405)
2013
5
Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature. (23564828)
2013
6
Goblet cell carcinoid of appendix: A rare case with literature review. (23416502)
2013
7
Goblet cell carcinoid in ascitic fluid. (22550034)
2013
8
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. (23088880)
2013
9
Serotonin- and somatostatin-positive goblet cell carcinoid of the duodenum. (22918208)
2012
10
Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination. (23304574)
2012
11
Goblet cell carcinoid and mucinous cystadenoma in an interval appendectomy specimen. (22273311)
2012
12
Schistosomiasis may contribute to goblet cell carcinoid of the appendix. (22746391)
2012
13
Goblet cell carcinoid of the vermiform appendix - a case report. (23359204)
2012
14
Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. (21874432)
2011
15
Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). (21753706)
2011
16
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. (22176273)
2011
17
Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. (20640606)
2011
18
Goblet cell carcinoid tumor: a rare cause of appendicitis. (21396295)
2011
19
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. (22107115)
2011
20
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. (20732910)
2010
21
Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. (20139759)
2010
22
Cervical and endometrial metastases of appendiceal goblet cell carcinoid. (20441511)
2010
23
Goblet cell carcinoid tumors of the appendix: An overview. (21160637)
2010
24
Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix. (19610147)
2009
25
Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? (18807600)
2008
26
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix. (18252007)
2008
27
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. (18685490)
2008
28
Goblet cell carcinoid of the appendix: a specific type of carcinoma. (18042066)
2007
29
Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix. (17049463)
2007
30
Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. (16485156)
2006
31
Goblet cell carcinoid of the appendix. (15967038)
2005
32
Goblet cell carcinoid of the appendix. (16013634)
2005
33
Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). (16136284)
2005
34
Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors. (14681318)
2003
35
Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin. (11350611)
2001
36
Goblet cell carcinoid of the appendix endoscopically diagnosed and examined with p53 immunostaining. (9719248)
1998
37
Goblet cell carcinoid of the appendix. (7978019)
1994
38
Goblet cell carcinoid of the appendix. (7949643)
1994
39
Goblet-cell carcinoid tumor in peritoneal fluid: a case report. (1648469)
1991
40
Goblet cell carcinoid of the vermiform appendix with ovarian metastasis mimicking mucinous cystadenocarcinoma. (1950561)
1991
41
Goblet cell carcinoid of the appendix. (2323597)
1990
42
Goblet cell carcinoid of the appendix. (2370022)
1990
43
Adenocarcinoid (goblet cell carcinoid) of the duodenum presenting as gastric outlet obstruction. (2307453)
1990
44
Goblet cell carcinoid of the appendix. (2753618)
1989
45
Goblet cell carcinoid tumour of the appendix. (6882644)
1983
46
Two cases of goblet cell carcinoid tumor of the appendix with bilateral ovarian metastases. (7113691)
1982
47
Canine goblet-cell carcinoid. (7257086)
1981
48
Goblet cell carcinoid of appendix: ultrastructural features and histogenetic aspects. (498041)
1979
49
Appendico-vesical fistula due to an appendix abscess with associated goblet cell carcinoid of the appendix. (188508)
1976
50
Goblet cell carcinoid of the appendix. An ultrastructural and histochemical study. (946758)
1976

Variations for Goblet Cell Carcinoid

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Expression for genes affiliated with Goblet Cell Carcinoid

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Expression patterns in normal tissues for genes affiliated with Goblet Cell Carcinoid

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Pathways for genes affiliated with Goblet Cell Carcinoid

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Pathways related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
RAC1 signaling pathway37
9.5CTNNB1, CDH1
29.5CDH1, CTNNB1
39.5CTNNB1, CDH1
49.5CDH1, CTNNB1
59.5CTNNB1, CDH1
6
Show member pathways
Signal transduction PTEN pathway60
9.5CTNNB1, CDH1
7
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
9.5CTNNB1, CDH1
89.5CTNNB1, CDH1
99.5CTNNB1, CDH1
109.5CDH1, CTNNB1
119.5CDH1, CTNNB1
129.5CTNNB1, CDH1
139.5CTNNB1, CDH1
149.5CDH1, CTNNB1
159.5CTNNB1, CDH1
169.5CTNNB1, CDH1
179.5CTNNB1, CDH1
18
Show member pathways
9.5CDH1, CTNNB1
199.5CTNNB1, CDH1

Compounds for genes affiliated with Goblet Cell Carcinoid

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Compounds related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1lithium chloride4410.0CHGA, CTNNB1
2pepsinogen449.9GAST, CHGA
3chlorophyllin449.9CDH1, CTNNB1
4misoprostol44 1110.9CHGA, GAST
5peptidylglycine449.9GAST, CHGA
6azoxymethane449.9GAST, CTNNB1
7cyclopamine44 6110.9CTNNB1, CDH1
8exisulind449.9CTNNB1, CDH1
9oxyntomodulin44 6110.8CHGA, GAST
10sodium bisulfite449.8CTNNB1, CDH1
11etodolac44 1110.8CTNNB1, CDH1
125-hydroxyindoleacetic acid44 2410.8CHGA, GAST
13gamma-linolenic acid44 2410.8CTNNB1, CDH1
14bicalutamide44 61 1111.8CTNNB1, CHGA
15ranitidine44 28 24 1112.7GAST, CHGA
16crcs449.6CTNNB1, CDH1
17omeprazole44 50 28 24 1113.5CHGA, GAST
18amide449.5CTNNB1, GAST, CHGA
19p002449.5CTNNB1, CDH1, CHGA
20bromodeoxyuridine449.5CHGA, GAST, CTNNB1
21sucrose44 24 1111.5CHGA, CDH1, CTNNB1
22gnrh449.4CTNNB1, GAST, CHGA
23carbachol44 28 1111.4CHGA, GAST, CDH1
24dfmo44 28 6111.4CTNNB1, CDH1, GAST
25acetaldehyde28 44 2411.4GAST, CDH1, CTNNB1
26celecoxib44 61 28 50 24 1114.4CTNNB1, CDH1, GAST
27matrigel449.4CHGA, CDH1, CTNNB1
28indole-3-carbinol449.4CTNNB1, CDH1
29polyacrylamide449.4CDH1, GAST, CHGA
30tamoxifen44 50 28 1112.3CHGA, CDH1, CTNNB1
31paclitaxel44 50 1111.3CTNNB1, CDH1, CHGA
32glycogen44 2410.3CHGA, CDH1, CTNNB1
33sb 20358044 6110.3CTNNB1, CDH1, GAST
34sulindac44 1110.2CTNNB1, CDH1
35b 723449.2CDH1, CEACAM7, CHGA
36paraffin449.2CTNNB1, CDH1, CHGA
37gefitinib44 50 1111.1CTNNB1, CDH1, CEACAM7
385fluorouracil449.0CEACAM7, CDH1, CTNNB1
39vitamin d449.0CHGA, GAST, CDH1, CTNNB1
40histamine44 28 2411.0CTNNB1, CDH1, GAST, CHGA
41cisplatin44 50 61 1112.0CHGA, GAST, CDH1, CTNNB1
42testosterone44 61 24 1112.0CTNNB1, CDH1, GAST, CHGA
43glutamine449.0CTNNB1, CDH1, GAST
44dexamethasone44 50 28 1112.0CHGA, GAST, CDH1, CTNNB1
45vegf449.0CTNNB1, CDH1, GAST, CHGA
46glutamate448.9CTNNB1, CDH1, GAST, CHGA
47butyrate448.9CTNNB1, CDH1, CEACAM7
48progesterone44 28 61 24 1112.7CHGA, CEACAM7, CDH1, CTNNB1
49retinoic acid44 249.6CTNNB1, CDH1, CEACAM7, CHGA
50estrogen448.2CTNNB1, CDH1, GAST, CEACAM7, CHGA

GO Terms for genes affiliated with Goblet Cell Carcinoid

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Cellular components related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.6CTNNB1, CDH1
2cell-cell adherens junctionGO:0059139.6CTNNB1, CDH1
3cytoplasmic side of plasma membraneGO:0098989.5CTNNB1, CDH1
4apical part of cellGO:0451779.5CTNNB1, CDH1
5lateral plasma membraneGO:0163289.4CDH1, CTNNB1
6perinuclear region of cytoplasmGO:0484718.8CTNNB1, CDH1, CHGA

Biological processes related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:0716819.6CTNNB1, CDH1
2regulation of protein localization to cell surfaceGO:20000089.5CTNNB1, CDH1
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.4CDH1, CTNNB1
4neuron migrationGO:0017649.4CTNNB1, ATOH1
5cell-cell adhesionGO:0163379.2CTNNB1, CDH1

Molecular functions related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.5CTNNB1, CDH1

Products for genes affiliated with Goblet Cell Carcinoid

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Sources for Goblet Cell Carcinoid

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet