GCC
MCID: GBL002
MIFTS: 47

Goblet Cell Carcinoid (GCC) malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Summaries for Goblet Cell Carcinoid

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Goblet cell carcinoid (gcc)is a rare type of neuroendocrine tumor that involves the appendix almost exclusively. it typically comes to attention in the fifth to sixth decade of life. signs and symptoms may include acute appendicitis, followed by abdominal pain and a mass. in about fifty percent of affected females, the tumor has metastasized to the ovary by the time of diagnosis. in general, approximately 76% of individuals with a gcc are alive five years after the diagnosis. prognosis largely depends on the stage of the disease (i.e. the size of the tumor and whether it has spread to other parts of the body). treatment often includes appendectomy and right hemicolectomy, followed by adjuvant chemotherapy in some cases. however, there is some debate about the extent of surgical treatment for these tumors. last updated: 6/25/2013

MalaCards: Goblet Cell Carcinoid, also known as goblet cell carcinoma, is related to adenocarcinoma and neuroendocrine tumor. An important gene associated with Goblet Cell Carcinoid is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are CDC42 signaling events and Adhesion. The compounds lithium chloride and pepsinogen have been mentioned in the context of this disorder. Affiliated tissues include appendix, ovary and lung, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Wikipedia:66 The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine... more...

Aliases & Classifications for Goblet Cell Carcinoid

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44NIH Rare Diseases, 50Orphanet, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

50
goblet cell carcinoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

goblet cell carcinoid 44 50
goblet cell carcinoma 44 50
goblet cell adenocarcinoid 50
carcinoid, goblet cell 63
carcinoid goblet cell 46
mucinous carcinoid 44
goblet cell tumor 50
gcc 50


Related Diseases for Goblet Cell Carcinoid

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18GeneCards, 19GeneDecks
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Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.5CHGA, CEACAM7, GAST, CDH1, CTNNB1
2neuroendocrine tumor30.4GAST, CHGA
3colorectal cancer30.3CEACAM7, GAST, CDH1, CTNNB1
4cystadenoma10.5
5schistosomiasis10.5
6peritonitis10.4
7neurofibromatosis10.2
8appendicitis10.2
9mucinous adenocarcinoma10.2
10mucinous cystadenocarcinoma10.2
11cervicitis10.2
12cystadenocarcinoma10.2
13mature teratoma10.2
14teratoma10.2
15gastric outlet obstruction10.2
16cerebellar liponeurocytoma10.1ATOH1
17merkel cell carcinoma10.1CHGA
18pernicious anemia10.1GAST
19signet ring cell adenocarcinoma10.0CDH1, CHGA
20adenosquamous carcinoma10.0CHGA, CEACAM7
21large cell carcinoma10.0CHGA, CEACAM7
22hyperinsulinemic hypoglycemia10.0GAST, CHGA
23pancreatic islet cell tumors10.0GAST, CHGA
24somatostatinoma10.0GAST, CHGA
25endocrine gland cancer10.0GAST, CHGA
26microinvasive gastric cancer10.0CDH1, GAST
27vipoma10.0GAST, CHGA
28zollinger-ellison syndrome10.0GAST, CHGA
29atrophic gastritis10.0CHGA, GAST
30glucagonoma10.0CHGA, GAST
31serotonin syndrome10.0CHGA, GAST
32stomach cancer10.0GAST, CDH1
33gastrinoma10.0CHGA, GAST
34primary hyperparathyroidism10.0CHGA, GAST
35multiple endocrine neoplasia10.0GAST, CHGA
36wermer syndrome10.0GAST, CHGA
37cystic fibrosis10.0
38leukemia10.0
39seminoma10.0
40glassy cell carcinoma of the cervix10.0
41mental retardation10.0
42germ cell cancer10.0
43paraganglioma10.0GAST, CHGA
44hyperparathyroidism10.0CHGA, GAST
45papillary carcinoma10.0CDH1, CHGA
46thyroid medullary carcinoma10.0GAST, CHGA
47hypercalcemia10.0GAST, CHGA
48diarrhea10.0CHGA, GAST
49gastritis10.0GAST, CHGA
50thyroid cancer, anaplastic10.0CDH1, CTNNB1

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to goblet cell carcinoid

Symptoms for Goblet Cell Carcinoid

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Drugs & Therapeutics for Goblet Cell Carcinoid

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Goblet Cell Carcinoid

Drug clinical trials:

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Search NIH Clinical Center for Goblet Cell Carcinoid

Search CenterWatch for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

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Anatomical Context for Goblet Cell Carcinoid

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34MalaCards
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MalaCards organs/tissues related to Goblet Cell Carcinoid:

34
Appendix, Ovary, Lung, Lymph node

Animal Models for Goblet Cell Carcinoid or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Goblet Cell Carcinoid:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3ATOH1, GAST, CDH1, CTNNB1
2MP:00053797.9CTNNB1, CDH1, GAST, CHGA, ATOH1
3MP:00107687.9CTNNB1, CDH1, GAST, CHGA, ATOH1
4MP:00053767.6ATOH1, CHGA, GAST, CDH1, CTNNB1

Publications for Goblet Cell Carcinoid

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53PubMed
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Articles related to Goblet Cell Carcinoid:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. (23833405)
2013
2
Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature. (23564828)
2013
3
Goblet cell carcinoid of appendix: A rare case with literature review. (23416502)
2013
4
Goblet cell carcinoid in ascitic fluid. (22550034)
2013
5
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. (23088880)
2013
6
Serotonin- and somatostatin-positive goblet cell carcinoid of the duodenum. (22918208)
2012
7
Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination. (23304574)
2012
8
Goblet cell carcinoid and mucinous cystadenoma in an interval appendectomy specimen. (22273311)
2012
9
Schistosomiasis may contribute to goblet cell carcinoid of the appendix. (22746391)
2012
10
Goblet cell carcinoid of the vermiform appendix - a case report. (23359204)
2012
11
Appendiceal goblet cell carcinoid tumour: a case of unexpected lung metastasis. (22933998)
2012
12
Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. (21874432)
2011
13
Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). (21753706)
2011
14
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. (22176273)
2011
15
Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. (20640606)
2011
16
Goblet cell carcinoid tumor: a rare cause of appendicitis. (21396295)
2011
17
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. (22107115)
2011
18
The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix. (21824598)
2011
19
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. (20732910)
2010
20
Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. (20139759)
2010
21
Cervical and endometrial metastases of appendiceal goblet cell carcinoid. (20441511)
2010
22
Goblet cell carcinoid tumors of the appendix: An overview. (21160637)
2010
23
Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix. (19610147)
2009
24
Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? (18807600)
2008
25
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix. (18252007)
2008
26
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. (18685490)
2008
27
Goblet cell carcinoid of the appendix: a specific type of carcinoma. (18042066)
2007
28
Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix. (17049463)
2007
29
Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. (16485156)
2006
30
Goblet cell carcinoid of the appendix. (15967038)
2005
31
Goblet cell carcinoid of the appendix. (16013634)
2005
32
Surgical treatment of appendiceal adenocarcinoid (goblet cell carcinoid). (16136284)
2005
33
Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors. (14681318)
2003
34
Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin. (11350611)
2001
35
Goblet cell carcinoid of the appendix endoscopically diagnosed and examined with p53 immunostaining. (9719248)
1998
36
Composite early carcinoma (ordinary adenocarcinoma, carcinoid, microglandular-goblet cell carcinoid, neuroendocrine mucinous carcinoma) of the stomach. (9675600)
1998
37
Goblet cell carcinoid of the appendix. (7978019)
1994
38
Goblet cell carcinoid of the appendix. (7949643)
1994
39
Goblet-cell carcinoid tumor in peritoneal fluid: a case report. (1648469)
1991
40
Goblet cell carcinoid of the vermiform appendix with ovarian metastasis mimicking mucinous cystadenocarcinoma. (1950561)
1991
41
Goblet cell carcinoid of the appendix. (2323597)
1990
42
Goblet cell carcinoid of the appendix. (2370022)
1990
43
Adenocarcinoid (goblet cell carcinoid) of the duodenum presenting as gastric outlet obstruction. (2307453)
1990
44
Goblet cell carcinoid of the appendix. (2753618)
1989
45
Goblet cell carcinoid tumour of the appendix. (6882644)
1983
46
Two cases of goblet cell carcinoid tumor of the appendix with bilateral ovarian metastases. (7113691)
1982
47
Canine goblet-cell carcinoid. (7257086)
1981
48
Goblet cell carcinoid of appendix: ultrastructural features and histogenetic aspects. (498041)
1979
49
Appendico-vesical fistula due to an appendix abscess with associated goblet cell carcinoid of the appendix. (188508)
1976
50
Goblet cell carcinoid of the appendix. An ultrastructural and histochemical study. (946758)
1976

Variations for Goblet Cell Carcinoid

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Expression for genes affiliated with Goblet Cell Carcinoid

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Goblet Cell Carcinoid

Search GEO for disease gene expression data for Goblet Cell Carcinoid.

Pathways for genes affiliated with Goblet Cell Carcinoid

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51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 54QIAGEN, 31KEGG, 61Thomson Reuters, 13EMD Millipore, 58SinoBiological, 56Reactome
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Pathways related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
RAC1 signaling pathway39
9.5CTNNB1, CDH1
29.5CDH1, CTNNB1
39.5CTNNB1, CDH1
49.5CTNNB1, CDH1
59.5CTNNB1, CDH1
6
Show member pathways
Signal transduction PTEN pathway61
9.5CDH1, CTNNB1
7
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion61
Pathogenic Escherichia coli infection39
9.5CDH1, CTNNB1
89.5CTNNB1, CDH1
99.5CTNNB1, CDH1
109.5CTNNB1, CDH1
119.5CTNNB1, CDH1
129.5CDH1, CTNNB1
139.5CDH1, CTNNB1
149.5CDH1, CTNNB1
159.5CTNNB1, CDH1
169.5CDH1, CTNNB1
179.5CTNNB1, CDH1
18
Show member pathways
9.5CTNNB1, CDH1
199.5CTNNB1, CDH1

Compounds for genes affiliated with Goblet Cell Carcinoid

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 52PharmGKB
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Compounds related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1lithium chloride4610.0CHGA, CTNNB1
2pepsinogen469.9GAST, CHGA
3chlorophyllin469.9CDH1, CTNNB1
4misoprostol46 1210.9CHGA, GAST
5peptidylglycine469.9GAST, CHGA
6azoxymethane469.9GAST, CTNNB1
7cyclopamine46 6210.9CTNNB1, CDH1
8exisulind469.9CTNNB1, CDH1
9oxyntomodulin46 6210.8CHGA, GAST
10sodium bisulfite469.8CTNNB1, CDH1
11etodolac46 1210.8CTNNB1, CDH1
125-hydroxyindoleacetic acid46 2510.8CHGA, GAST
13gamma-linolenic acid46 2510.8CTNNB1, CDH1
14bicalutamide46 62 1211.8CTNNB1, CHGA
15ranitidine46 30 25 1212.7GAST, CHGA
16crcs469.6CTNNB1, CDH1
17omeprazole46 52 30 25 1213.5CHGA, GAST
18amide469.5CTNNB1, GAST, CHGA
19p002469.5CTNNB1, CDH1, CHGA
20bromodeoxyuridine469.5CHGA, GAST, CTNNB1
21sucrose46 25 1211.5CHGA, CDH1, CTNNB1
22gnrh469.4CTNNB1, GAST, CHGA
23carbachol46 30 1211.4CHGA, GAST, CDH1
24dfmo46 30 6211.4CTNNB1, CDH1, GAST
25acetaldehyde30 46 2511.4GAST, CDH1, CTNNB1
26celecoxib46 62 30 52 25 1214.4CTNNB1, CDH1, GAST
27matrigel469.4CHGA, CDH1, CTNNB1
28indole-3-carbinol469.4CTNNB1, CDH1
29polyacrylamide469.4CDH1, GAST, CHGA
30tamoxifen46 52 30 1212.3CHGA, CDH1, CTNNB1
31paclitaxel46 52 1211.3CTNNB1, CDH1, CHGA
32glycogen46 2510.3CHGA, CDH1, CTNNB1
33sb 20358046 6210.3CTNNB1, CDH1, GAST
34sulindac46 1210.2CTNNB1, CDH1
35b 723469.2CDH1, CEACAM7, CHGA
36paraffin469.2CTNNB1, CDH1, CHGA
37gefitinib46 52 1211.1CTNNB1, CDH1, CEACAM7
385fluorouracil469.0CEACAM7, CDH1, CTNNB1
39vitamin d469.0CHGA, GAST, CDH1, CTNNB1
40histamine46 30 2511.0CTNNB1, CDH1, GAST, CHGA
41cisplatin46 52 62 1212.0CHGA, GAST, CDH1, CTNNB1
42testosterone46 62 25 1212.0CTNNB1, CDH1, GAST, CHGA
43glutamine469.0CTNNB1, CDH1, GAST
44dexamethasone46 52 30 1212.0CHGA, GAST, CDH1, CTNNB1
45vegf469.0CTNNB1, CDH1, GAST, CHGA
46glutamate468.9CTNNB1, CDH1, GAST, CHGA
47butyrate468.9CTNNB1, CDH1, CEACAM7
48progesterone46 30 62 25 1212.7CHGA, CEACAM7, CDH1, CTNNB1
49retinoic acid46 259.6CTNNB1, CDH1, CEACAM7, CHGA
50estrogen468.2CTNNB1, CDH1, GAST, CEACAM7, CHGA

GO Terms for genes affiliated with Goblet Cell Carcinoid

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17Gene Ontology
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Cellular components related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.6CTNNB1, CDH1
2cell-cell adherens junctionGO:0059139.6CTNNB1, CDH1
3cytoplasmic side of plasma membraneGO:0098989.5CTNNB1, CDH1
4apical part of cellGO:0451779.5CTNNB1, CDH1
5lateral plasma membraneGO:0163289.4CDH1, CTNNB1
6perinuclear region of cytoplasmGO:0484718.8CTNNB1, CDH1, CHGA

Biological processes related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:0716819.6CTNNB1, CDH1
2regulation of protein localization to cell surfaceGO:20000089.5CTNNB1, CDH1
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.4CDH1, CTNNB1
4neuron migrationGO:0017649.4CTNNB1, ATOH1
5cell-cell adhesionGO:0163379.2CTNNB1, CDH1

Molecular functions related to Goblet Cell Carcinoid according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.5CTNNB1, CDH1

Products for genes affiliated with Goblet Cell Carcinoid

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Sources for Goblet Cell Carcinoid

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet