MCID: GBL002
MIFTS: 33

Goblet Cell Carcinoid malady

Categories: Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Goblet Cell Carcinoid

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Sources:
31ICD10 via Orphanet, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Goblet Cell Carcinoid:

Name: Goblet Cell Carcinoid 48 54
Goblet Cell Adenocarcinoid 48 54
Goblet Cell Carcinoma 48 54
Goblet Cell Tumor 48 54
 
Gcc 48 54
Carcinoid, Goblet Cell 68
Carcinoid Goblet Cell 50
Mucinous Carcinoid 48

Characteristics:

Orphanet epidemiological data:

54
goblet cell adenocarcinoid:
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly

Classifications:



External Ids:

Orphanet54 ORPHA329984
ICD10 via Orphanet31 C18.1

Summaries for Goblet Cell Carcinoid

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NIH Rare Diseases:48 Goblet cell carcinoid (GCC) is a rare tumor normally occurring in the appendix which displays features of both a neuroendocrine tumor and a more aggressive form of cancer known as an adenocarcinoma. It is usually diagnosed in people over the age of 50. People with this tumor may develop acute appendicitis, abdominal pain, and diarrhea. Prognosis largely depends on the size of the tumor and whether it has spread to other parts of the body. Treatment involves surgery to remove the tumor. Depending on how much the tumor has spread, surgeons may remove the appendix, part of the colon, or the ovaries (in women). Some people will have chemotherapy after surgery. Last updated: 8/17/2016

MalaCards based summary: Goblet Cell Carcinoid, also known as goblet cell adenocarcinoid, is related to glassy cell carcinoma of the cervix and sensory system cancer. An important gene associated with Goblet Cell Carcinoid is CDH1 (Cadherin 1), and among its related pathways are Stabilization and expansion of the E-cadherin adherens junction and Arf6 trafficking events. Affiliated tissues include appendix, ovary and lung.

Wikipedia:71 The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine... more...

Related Diseases for Goblet Cell Carcinoid

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Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1glassy cell carcinoma of the cervix10.8
2sensory system cancer10.5CHGA, KRT20
3pulmonary neuroendocrine tumor10.5CHGA, KRT20
4cellular phase chronic idiopathic myelofibrosis10.5CHGA, KRT20
5steatitis10.5CDH1, KRT20
6adenoid basal cell carcinoma10.5CDH1, KRT20
7middle ear squamous cell carcinoma10.5CDH1, KRT20
8food allergy10.4CHGA, KRT20
9comedo carcinoma10.4CDH1, KRT20
10lateral sinus thrombosis10.4CDH1, KRT20
11esophagus small cell carcinoma10.4CHGA, ENO2
1212p12.1 microdeletion syndrome10.4CDH1, CTNNB1
13vulva basal cell carcinoma10.4CDH1, KRT20
14mixed endometrial stromal and smooth muscle tumor10.4CHGA, ENO2
15norwegian scabies10.4CHGA, ENO2
16caroli disease10.4CHGA, KRT20
17pilocytic astrocytoma10.4CHGA, ENO2
18peripheral nervous system ganglioneuroblastoma10.4CHGA, ENO2
19ureterocele10.4CDH1, CHGA
20subpulmonary stenosis10.4CHGA, ENO2
21breast pericanalicular fibroadenoma10.4CHGA, KRT20
22brain stem ependymoma10.4CHGA, ENO2
23pneumonia10.4CHGA, ENO2
24gallbladder signet ring cell adenocarcinoma10.4CDH1, ENO2
25persian gulf syndrome10.4CDH1, KRT20
26verruciform xanthoma of skin10.4CHGA, CTNNB1
27ovarian clear cell malignant adenofibroma10.4CHGA, ENO2
28expressive language disorder10.4CHGA, ENO2
29xanthogranulomatous pyelonephritis10.3CHGA, ENO2
30urethral villous adenoma10.3CHGA, ENO2
31mediastinal melanocytic neurilemmoma10.3CTNNB1, KRT20
32paranasal sinus cancer, adult10.3CHGA, ENO2
33schwannoma of ureter10.3CHGA, ENO2
34breast malignant phyllodes tumor10.3CDH1, CTNNB1
35intestinal benign neoplasm10.3CDH1, ENO2
36poliomyelitis10.3CHGA, CTNNB1
37sphenoidal sinus cancer10.3ENO2, KRT20
38restrictive cardiomyopathy10.3CHGA, KRT20
39localized pulmonary fibrosis10.3ENO2, KRT20
40carcinoma of the vocal tract10.3CHGA, ENO2
41primary syphilis10.3CDH1, ENO2
42synchronous bilateral breast carcinoma10.3CHGA, ENO2
43ovarian cancer, somatic10.3CDH1, CTNNB1
44pediatric testicular germ cell tumor10.3ENO2, KRT20
45periapical granuloma10.2CDH1, CTNNB1
46bartholin's gland small cell carcinoma10.2CTNNB1, KRT20
47pemphigus vulgaris, familial10.2CEACAM7, KRT20
48megarbane jalkh syndrome10.2CHGA, ENO2
49stromal keratitis10.2CDH1, CTNNB1
50lateral medullary syndrome10.2CTNNB1, ENO2

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to goblet cell carcinoid

Symptoms & Phenotypes for Goblet Cell Carcinoid

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Drugs & Therapeutics for Goblet Cell Carcinoid

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

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Anatomical Context for Goblet Cell Carcinoid

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MalaCards organs/tissues related to Goblet Cell Carcinoid:

36
Appendix, Ovary, Lung, Lymph node

Publications for Goblet Cell Carcinoid

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Articles related to Goblet Cell Carcinoid:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. (27338636)
2016
2
Goblet-cell carcinoid of the ovary: A case report with ultrastructural analysis. (27922277)
2016
3
Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1. (27237132)
2016
4
Synchronous sessile serrated adenoma and goblet cell carcinoid in the appendix: A case report and literature review. (27773125)
2016
5
Goblet cell carcinoid tumor, mixed goblet cell carcinoid-adenocarcinoma, and adenocarcinoma of the appendix: comparison of clinicopathologic features and prognosis. (26030247)
2015
6
Peritoneal metastatic goblet-cell carcinoid tumor treated with cytoreductive surgery and intraperitoneal chemotherapy. (25960976)
2015
7
A rare combination of ovarian and uterine leiomyomas with goblet cell carcinoid of the appendix. (25685587)
2015
8
Simplified 2-tier histologic grading system accurately predicts outcomes in goblet cell carcinoid of the appendix. (26433702)
2015
9
Late recurrence and metastasis of an appendiceal goblet cell carcinoid 24 years after appendectomy. (24451973)
2014
10
Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory? (24943968)
2014
11
Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: a case report with review of literature. (24739849)
2014
12
EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix. (24560515)
2014
13
Goblet cell carcinoid of appendix: A rare case with literature review. (23416502)
2013
14
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. (23088880)
2013
15
Appendiceal goblet cell carcinoid and mucinous neoplasms are closely associated tumors: Lessons from their coexistence in primary tumors and concurrence in peritoneal dissemination. (24374723)
2013
16
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. (23833405)
2013
17
Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature. (23564828)
2013
18
Goblet cell carcinoid in ascitic fluid. (22550034)
2013
19
Goblet cell carcinoid tumor of the appendix. (24224299)
2013
20
Serotonin- and somatostatin-positive goblet cell carcinoid of the duodenum. (22918208)
2012
21
Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination. (23304574)
2012
22
Goblet cell carcinoid and mucinous cystadenoma in an interval appendectomy specimen. (22273311)
2012
23
Schistosomiasis may contribute to goblet cell carcinoid of the appendix. (22746391)
2012
24
Goblet cell carcinoid of the vermiform appendix - a case report. (23359204)
2012
25
Appendiceal goblet cell carcinoid tumour: a case of unexpected lung metastasis. (22933998)
2012
26
Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. (21874432)
2011
27
Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). (21753706)
2011
28
Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. (20640606)
2011
29
Goblet cell carcinoid tumor: a rare cause of appendicitis. (21396295)
2011
30
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. (22107115)
2011
31
The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix. (21824598)
2011
32
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. (22176273)
2011
33
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. (20732910)
2010
34
Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (20631606)
2010
35
Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. (20139759)
2010
36
Cervical and endometrial metastases of appendiceal goblet cell carcinoid. (20441511)
2010
37
Goblet cell carcinoid tumors of the appendix: An overview. (21160637)
2010
38
Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix. (19610147)
2009
39
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. (19471156)
2009
40
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix. (18252007)
2008
41
Goblet cell carcinoid tumours of the appendix: a unique neuroendocrine tumour. (18439158)
2008
42
Goblet cell carcinoid of the appendix: laparoscopic appendectomy or right hemicolectomy? (18807600)
2008
43
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. (18685490)
2008
44
Laparoscopic right hemicolectomy for goblet-cell carcinoid of the appendix: report of a rare case and literature survey. (18503377)
2008
45
Cytology of metastatic appendiceal goblet cell carcinoid in pleural effusion fluid: a case report. (18855885)
2008
46
Goblet cell carcinoid of the appendix: a specific type of carcinoma. (18042066)
2007
47
Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix. (17049463)
2007
48
Goblet cell carcinoid tumors (adenocarcinoid) of the appendix. (17195086)
2007
49
Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. (16485156)
2006
50
Management of goblet cell carcinoid. (16967437)
2006

Variations for Goblet Cell Carcinoid

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Expression for genes affiliated with Goblet Cell Carcinoid

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Search GEO for disease gene expression data for Goblet Cell Carcinoid.

Pathways for genes affiliated with Goblet Cell Carcinoid

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GO Terms for genes affiliated with Goblet Cell Carcinoid

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Cellular components related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical junction complexGO:004329610.2CDH1, CTNNB1
2catenin complexGO:001634210.2CDH1, CTNNB1
3flotillin complexGO:001660010.1CDH1, CTNNB1
4lateral plasma membraneGO:00163289.7CDH1, CTNNB1

Biological processes related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1adherens junction organizationGO:003433210.2CDH1, CTNNB1
2cellular response to indole-3-methanolGO:007168110.1CDH1, CTNNB1
3cellular response to lithium ionGO:007128510.1CDH1, CTNNB1
4negative regulation of neuron deathGO:19012159.6CHGA, CTNNB1

Sources for Goblet Cell Carcinoid

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet